Cellucor XTEND® EAA Essential Amino Acids Powder Review
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Study, Trial or Testing Result Summary
Members Only7 human studies · 5 improved
No study given here tested an essential amino acid powder like this one for blood pressure, so the evidence for this product is thin. The strongest trial gave the single amino acid lysine, not a full blend, to adults in Ghana for 16 weeks. In those with high blood pressure, the top number fell from about 146 to 129, while the placebo group stayed about the same [1]. In people with advanced kidney disease, a very low protein diet plus amino acid ketoanalogues for 6 months lowered blood pressure from 143 over 84 to 128 over 78 [2]. That is a special medical diet, not a powder taken on its own. Two reports of one kidney disease trial found that swapping animal protein for soy limited a rise in blood pressure, which says more about protein source than about amino acid supplements [3][4]. A large Korean survey linked diets with more essential amino acids to less high blood pressure, but it cannot show cause [5]. In healthy older adults, one protein source raised blood pressure slightly, possibly because of its salt [6]. Reviews are very positive, but none could be read, so it is unknown whether they mention blood pressure. Animal and cell studies are never counted.
See all 7 studies →Hide the studies
- In 180 adults in Ghana (50 with high blood pressure), lysine supplementation for 112 days lowered systolic blood pressure in hypertensive people from about 146 to 129 mmHg, while the placebo group stayed about the same.Effect of lysine supplementation on hypertensive men and women in selected peri-urban community in Ghana.
- In 85 people with moderate to advanced kidney disease on a low protein diet plus amino acid ketoanalogues for 12 months, replacing animal protein with soy protein limited the rise in central systolic blood pressure (+2.6% vs +13.0%) compared with the animal protein diet.[Soy protein as part of a low-protein diet is a new direction in cardio- and nephroprotection in patients with 3B-4 stag…
- In 85 people with moderate to advanced kidney disease on a low protein diet plus amino acid ketoanalogues for 12 months, soy protein instead of animal protein limited the rise in central systolic blood pressure (+2.6% vs +13.0%).Soy Protein as a Part of a Low-protein Diet is a New Direction in Cardio- and Nephroprotection in Patients With 3b-4 Sta…
- In 110 people with advanced kidney disease, a very low protein diet with essential amino acid ketoanalogs for 6 months lowered blood pressure from 143/84 to 128/78 mmHg, while blood pressure did not fall in the low protein or free diet groups.Very low protein diet supplemented with ketoanalogs improves blood pressure control in chronic kidney disease.
- In 36 healthy older adults given 40 g a day of different proteins for one week each, all supplied essential amino acids, but bovine plasma protein caused a small rise in blood pressure, possibly from its salt content.Evaluating and comparing tolerance, nutritional quality and bio-functional activity of bovine-plasma, corn and whey prot…
- In a large survey of Korean adults aged 30 and over, those whose diets met more of the recommended essential amino acid intake had a lower chance of high blood pressure, though this was a cross-sectional study that cannot show cause.Higher Intake of Total Dietary Essential Amino Acids Is Associated with a Lower Prevalence of Metabolic Syndrome among K…
- In a small study of pregnant women at a clinic, those with toxemia (which includes high blood pressure) ate more of every essential amino acid than women without it, so the link between amino acid intake and toxemia was complex and did not show a protective effect.Protein, amino acid, and caloric intakes of selected pregnant women.
Review Totals and Summary
Members Only13,000 reviews · 90% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Most of the panel recommends essential amino acids, with eight of the ten giving a recommending position and one of them having stopped. They mainly take them to support muscle building, repair and recovery, with several singling out leucine, and some use them while fasting or eating less protein to protect muscle and curb appetite or sugar cravings. One panelist takes 20 grams a day, split over two servings, and others take them before, during or after training; a pre-digested powder blend was named as an easy-to-absorb form. One panelist pairs them with kava for recovery, and another suggests having them in the morning while fasting other foods. On the cautious side, one panelist stopped using them during workouts because leucine can spike insulin, keeping them only for long efforts like rucking or mountaineering, while another said they are not needed for building extra muscle if you already eat a nutritious diet, and one noted the only real downside is cost.
See all 9 biohackers →Hide the biohackers
Thomas DeLauer · Essential Amino Acids · stopped
- Stopped having essential amino acids (EAAs) during his workouts because leucine can spike insulin, making it harder to drop fat without noticeable muscle preservation. He now only uses EAAs for long-duration activities like rucking or mountaineering.
- Uses essential amino acids as part of their staggered fuel approach before training on their pre-fast day.
- Has noticed that using EAAs makes a big difference in how much protein they need and personally uses PerfectAmino, finding it easier on digestion and calories to occasionally boost with them.
- Sips essential aminos through the day for appetite control and to maximize leucine for protein synthesis while in a deficit.
- Recommends stacking Kava with essential aminos for recovery.
- Recommends essential amino acids (EAAs) for muscle building, noting that acute intake increases muscle protein synthesis and consistent supplementation increases basal muscle protein synthesis, lean mass, and IGF-1 expression.
- Recommends essential amino acids, especially for older individuals trying to maintain muscle, suggesting that a scoop with meals could make the difference for adequate muscle protein synthesis.
- Recommends sipping on essential amino acids throughout the day, especially when in a caloric deficit, to keep leucine levels high and prevent muscle loss.
- Mentions that essential amino acids could potentially help after a workout in reaching a protein leverage point.
- Has strategically implemented essential amino acids into his life for over a decade, stating he doesn't know if he'd look the way he looks without them, and suggests sipping on EAAs throughout the day or more importantly along with meals, especially when in a serious caloric deficit.
Ben Greenfield · Essential Amino Acids · recommends
- Emphasizes the importance of essential amino acids, especially leucine-rich ones, for muscle protein synthesis and to blunt muscle loss during bed rest and after surgery, citing NASA bed rest studies.
- Ben Greenfield and his sons take essential amino acids twice daily.
- Currently takes essential amino acids.
- Mentions that a vegan diet isn't matched in essential amino acids compared to an animal diet.
- States they personally take 20 g/day of EAAs (essential amino acids).
- Recommends Essential amino acids, stating they help kick-start muscle building.
- Tries to shoot for at least 20g of essential amino acids (EAA’s) per day.
- While animal protein sources and essential amino acids are still my #1 protein priority, it’s good to know that collagen still produces impactful results for multiple aspects of your biology.
- Is a strong proponent of essential amino acids for stimulating muscle building, especially as one ages, and personally uses 10 to 20 grams pre-workout and post-workout, specifically the watermelon flavor from Keon.
- Applies research from NASA about essential amino acids (EAAs) preserving muscle during inactivity for recovery and protein synthesis.
Dr. Rhonda Patrick · Essential Amino Acids · recommends
- States that essential amino acids, particularly leucine, are major regulators of muscle protein synthesis and are very important.
- Discusses the importance of complete protein and essential amino acids for postmenopausal women.
Dave Asprey · Essential Amino Acids · recommends
- Recommends essential amino acids as the building blocks the body uses to build and repair muscle, suggesting they work like a multivitamin to fill dietary gaps.
Peter Attia · Essential Amino Acids · recommends
- Emphasizes the importance of getting essential amino acids, particularly leucine, for triggering muscle protein synthesis.
- Mentions that they have done work with essential amino acids around exercise, which really helps optimize the maintenance of lean mass.
- Clarifies that essential amino acids are those our bodies cannot synthesize, while non-essential ones can be synthesized to some extent.
- Suggests that if people are worried about intermittent fasting, they should fast their carbohydrate and fat intake and have essential amino acids in the morning.
- Peter Attia's guest learned in graduate school that we don't really have a protein requirement, but rather a requirement for nine essential amino acids and organic nitrogen.
Dr. Mark Hyman · Essential Amino Acids · recommends
- Recommends essential amino acids for building and repairing muscle, supporting recovery, and maintaining overall metabolic health, noting that the body cannot make these nine amino acids on its own.
- Uses essential amino acids to support muscle repair and recovery, maintain overall metabolic health, and complement his diet.
- Explains that essential amino acids are crucial for building and repairing muscle, supporting recovery, and maintaining overall metabolic health, and must be obtained from food or supplements.
- States that he supplements with essential amino acids, specifically Body Health Perfect Aminos, to increase protein intake for recovery and muscle stimulation, especially since he trains hard.
- Initially recommends a blend of all essential amino acids, sometimes increasing with 5-HTP and phenylalanine, in a pre-digested powder form for easy absorption.
- Emphasizes the importance of consuming essential amino acids, which come in the form of high-quality proteins like beef, fish, chicken, and eggs.
- Discusses research where controlling essential amino acids in mice with Alzheimer's mutations was sufficient to reduce cognitive impairment and protect them for longer.
- States that they published a paper showing that alternating high and low essential amino acid intake, which affects IGF-1 levels, was sufficient to reduce cognitive impairment and protect mice with Alzheimer's-like symptoms for longer.
- Recommends essential amino acids for building muscle, participating in gut-brain communication, and influencing pathways involved in mood and sleep.
- He states that essential amino acids matter for maintaining muscle, metabolism, and strength as we age, and also support the heart.
Siim Land · Essential Amino Acids · recommends
- States that essential amino acids and branched-chain amino acids reduce muscle soreness for regular people.
- States that essential amino acids are 'okay' and beneficial for those on a low protein diet or fasting, but not for building additional muscle if one already eats a nutritious diet.
- Used to take essential amino acids in the past but no longer does, as he has already tested most supplements.
- States that Essential Amino Acids are beneficial for those on a low protein diet or fasting frequently, but not for building additional muscle if one already consumes a nutritious diet.
- Uses essential amino acids, finding them especially effective in a fasted state for muscle anabolism and reducing muscle catabolism.
- Uses essential amino acids to increase protein synthesis and help maintain and build muscle tissue, finding them especially effective in the context of his intermittent fasting.
- Siim Land recommends Essential Amino Acids, offering a 15% discount with a code.
- Sometimes has amino acids in the morning, noting that essential amino acids may induce autophagy and suppress muscle catabolism without raising insulin or turning on mTOR in the absence of actual protein.
- Recommends Essential Amino Acids, offering a 15% discount code for them.
- Mentions a 15% discount code for Essential Amino Acids.
Andrew Huberman · Essential Amino Acids · recommends
- Encourages ensuring sufficient essential amino acids, especially leucine, to support muscle growth.
- Notes that there are 20 different amino acids, each with unique metabolic roles, and highlights tryptophan for serotonin production and threonine for mucin production.
- Highlights that essential amino acids, which make up proteins, are absolutely necessary for survival as the body cannot synthesize them.
- Regularly uses essential amino acids, sometimes pre, mid, or post-training, noting there is no real harm other than cost and that they may slightly help maximize recovery.
- Mentions that he has talked about making sure one is getting enough essential amino acids as a way to reduce sugar cravings.
Dr. Eric Berg · Essential Amino Acids · recommends
- Recommends consuming meat, fish, eggs, and organ meats to obtain all essential amino acids and bioavailable nutrients, which are not directly available from grains or beans.
- Recommends Keto Essential Amino Acids for sarcopenia (age-related muscle loss).
- Recommends essential amino acid blends, especially when fasting, to ensure no muscle loss.
- Mentions that some people take certain combinations of essential amino acids as a supplement while fasting to get all amino acids except glutamine, as a strategy to avoid glutamine which cancer lives on.
- Dr. Berg states that the body needs all 9 essential amino acids for recovery, repair, and regrowth of proteins.
- States that he is currently taking essential amino acids to enhance his protein amounts because they offer a 99% effect in turning into body tissue with only 1% waste.
- Dr. Berg states that essential amino acids cannot be made by the body and must be obtained from the diet, as gut microbes do not produce them in sufficient quantities.
RAL Summary
Members OnlyTier 4 for Blood Pressure
The tier rests on studies that did not test an essential amino acid blend like this one: one trial used lysine alone, the kidney disease trials used amino acid ketoanalogues with special low protein diets, and the remaining studies compared whole protein sources or dietary intake. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Kidneys
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported for essential amino acid supplements. One study found that a bovine plasma protein source caused a small rise in blood pressure, possibly from its salt content.
Supplement Facts
Includes 0g Added Sugars 0 g · Potassium 120 mg · XTEND EAA Amino Blend 5 g
| Calories | 25 | |
| Total Carbohydrate | 1 g | |
| Total Sugars | 0 g | |
| Includes 0g Added Sugars | 0 g | |
| Sodium | 150 mg | |
| Potassium | 120 mg | |
| XTEND EAA Amino Blend | 5 g | † |
Other ingredients: Citric Acid, Natural Flavors, Malic Acid, Acesulfame Potassium, Sucralose, Silicon Dioxide, Calcium Silicate, Beta-Carotene (Color), Vegetable Juice (Color).
Directions: As a dietary supplement, mix 1 serving in 8-10 fl. oz. of water (adjust for taste preference) and shake well. For best results, take 2 servings per day.
Barcode (UPC) 842595133233 · Label source: Reverseagelab · Report a label change
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- How to Lower Diastolic Blood Pressure for LongevityArticle · Sep 17, 2026
- DASH Diet for High Blood Pressure: What It Lowers, What to Eat, and How to StartArticle · Sep 19, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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