Doctor's Best Boswellia with UC-II Review

Doctor's Best Boswellia + UC-II Supplement, for Men & Women, is a 60 count bottle of Veg Caps listed on Amazon as a Boswellia Serrata Extract capsule for joint health support. The Amazon listing describes a unique blend that includes Boswellia and type II collagen, offered as a comprehensive formula for smooth and flexible joints. The product highlights say the formula supports joint comfort and mobility, and that by helping to maintain healthy cartilage, UC-II can help support joint health and mobility for an active lifestyle. According to the bullet points, Boswellia + UC-II Supplement provides 500 mg of Boswellia extract and 40 mg of UC-II (Undenatured Type II Collagen) per 2-capsule serving. The product is listed as gluten free, soy free, and non-GMO. The suggested use is to take 2 Boswellia serrata extract capsules daily, preferably on an empty stomach, or as recommended by a nutritionally informed physician. The listing states that the item is unflavored, has a Capsule item form, and comes in a bottle with 60 count. The product benefits section lists bone and joint support and immune support, and notes that boswellia supports the health of joint components called glycosaminoglycans, a group of molecules that provide lubrication for joints. The brand describes itself as having been dedicated to providing thoroughly researched, rigorously tested, and clinically approved supplements for over 35 years, and says good nutrition starts with sound science. The item is sold by Doctors Best and ships from Amazon. The listing notes that the item is non-returnable due to food safety reasons, though damaged or defective items may be refunded or replaced. The product's Amazon Best Sellers Rank is number 15 in Boswellia Serrata. The model number is DRB-00601 and the UPC is 753950006010.

Product Focus: Joints and MobilityAlso covers:Immune system
Tier ⓘ
Tier 3 · Rank 10
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 10 within Tier 3 for Joints and Mobility; 46 of 79 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
72 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
96% of 407
Biohacker Mentions
8 of 10
Cost per month
$22

Study, Trial or Testing Result Summary

Members Only68 human studies · 56 improved
68 human studies56 improved5 no effect28,290 people studied

Both studied ingredients are present at or above the doses used in studies. Boswellia is given at 500 milligrams a day, more than the 100 milligrams that worked in trials. In a review of 49 trials, 90 days of 100 milligrams of an enriched extract cut knee arthritis pain by about 17 points on a 100-point scale and improved function compared with placebo [1]. A pooled analysis of 39 trials ranked Boswellia highest of seven supplements for pain and stiffness, with no added side effects [2], and another of 20 trials agreed [3]. In an 80-person trial, 180 days improved pain and function and increased cartilage thickness on scans [4]. One 30-day trial saw benefits by day 5 [5]. Undenatured type II collagen is given at 40 milligrams, the same dose that, over 180 days in 191 people with knee arthritis, eased symptoms more than placebo and more than glucosamine with chondroitin [6]. A pooled analysis of 23 trials ranked it among the top supplements for joint pain and function, though evidence quality was low [7]. In healthy active adults, 40 milligrams for 24 weeks improved knee bending more than placebo [8]. Benefits seen in the medium term were not clear in the long term [9]. Animal and cell studies are never counted.

See all 68 studies →Hide the studies

Review Totals and Summary

Members Only407 reviews · 96% positive
407 reviews · IHerb 293 · Amazon 85 · Vitacost 27 · TheraStore 1 · Target 1
96% positive0% neutral4% negative

Doctor's Best Boswellia with UC-II capsules generally receive very positive feedback, with 100% of star ratings being 4 or 5 across approximately 406 total ratings. Buyers are largely satisfied, expecting and often experiencing benefits for joint health and mobility. **What it did** Many users report positive effects on joint health and comfort. One buyer "felt much better with my knee after 2 days," indicating quick relief. The product is described as helping to "effectively reduces inflammation" and supporting cartilage restoration. It also aims to "significantly improve mobility, reduce joint discomfort, and maintain joint flexibility." Another reviewer found it provided "Effective relief for joint pain." Overall, customers expect joint comfort and mobility benefits. **Complaints** There are no complaints about the product's effectiveness, taste, capsule size, or side effects in the provided feedback. Store summaries confirm this absence, noting no complaints about "taste, capsule size, or side effects." One store summary did observe a single lower rating among 27 total ratings on its page, but no details about the reason for that rating are available from customer feedback. **Taste, Smell, Pill Size, Form** The product comes in "good quality size 60 vegies" (vegetarian capsules). Reviewers appreciate the vegetarian form, noting that "Vegetarian capsules help significantly improve mobility." There are no complaints regarding the taste, smell, or size of the capsules. This summary focuses exclusively on feedback for the capsule form of the product, excluding any reviews or summaries pertaining to other forms like gummies or powders. **Value for Money** General satisfaction with the product's quality and value is a common theme among buyers. **Who it suits** The product appears suitable for individuals seeking support for joint health, mobility, and inflammation. It's seen as a "comprehensive solution for active longevity and musculoskeletal health." Some users purchased it on a doctor's recommendation, indicating professional endorsement for specific cases; for example, one buyer stated it "was recommended by doctor." While many report quick benefits, some new users are still assessing results over a longer period. No feedback suggests it did not suit anyone.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Five of the seven panelists who spoke about Boswellia, the main ingredient, recommend it, mostly as an anti-inflammatory; one of them says it has the most evidence of the supplements he named for recovering from brain injury, and two say it targets a separate inflammation pathway that curcumin misses. One pairs it with celery seed, one is neutral and simply calls it a tool for inflammatory issues, and one warns that it gave him muscle pain. No one gave a dose or a preferred form for Boswellia. Collagen is a smaller ingredient in this product, and most of the panel uses or recommends it, with typical doses of 10 grams a day, while one has stopped taking it and two doubt its value for building muscle.

See all 10 biohackers →Hide the biohackers
  • Andrew Huberman · Boswellia · recommends
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Boswellia, an Indian frankincense extract, has the most evidence among other supplements for TBI recovery, having shown some benefit in three clinical trials.
    • 7 Aug 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 20 Jul 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 13 Jul 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 6 Jul 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for skin health.
    • 22 Jun 2026 · Collagen · uses · X ↗
      Takes 10 grams of collagen in the morning for muscle.
    • 17 Jun 2026 · Collagen · uses · X ↗
      Takes 10-20 grams of Collagen every day for muscle.
    • 6 Jun 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 22 May 2026 · Collagen · uses · X ↗
      He takes 10 grams of Collagen in the morning for muscle.
    • 11 May 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for skin health.
    • 4 May 2026 · Collagen · uses · X ↗
      He takes 10 grams of Collagen in the morning for skin health.
    • 22 Feb 2023 · neutral · YouTube ↗
      Mentions Boswellia as having some potential benefit for inflammation, but notes it's not typically used unless in very specific circumstances like an injury.
  • Thomas DeLauer · Boswellia · recommends
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends boswellia as a runner-up for inflammation, noting it inhibits 5-LOX, an enzyme targeting a separate inflammatory pathway that curcumin misses.
    • 5 Nov 2026 · Collagen · recommends · YouTube ↗
      Recommends taking collagen peptides in the morning for tendon tensile effects and 5 or 10 grams at night before bed to couple with the body's natural growth hormone pulse for skin and connective tissue repair.
    • 4 Nov 2026 · Collagen · uses · YouTube ↗
      Would add more collagen to his protein shakes, believing it helps connective tissue protein synthesis and works synergistically with whey protein for muscle protein synthesis.
    • 29 Oct 2026 · Collagen · uses · YouTube ↗
      Says he takes collagen to take care of his gut.
    • 26 Oct 2026 · Collagen · recommends · YouTube ↗
      Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
    • 19 Oct 2026 · Collagen · recommends · YouTube ↗
      Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
    • 14 Oct 2026 · Collagen · uses · YouTube ↗
      Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
    • 9 Oct 2026 · Collagen · neutral · YouTube ↗
      Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
    • 8 Sep 2026 · Collagen · recommends · YouTube ↗
      Recommends taking 15 grams of collagen about 30 minutes before bed, especially on rest days, for its glycine content to aid sleep onset and for connective tissue repair.
    • 6 Sep 2026 · Collagen · recommends · Instagram ↗
      Recommends opting for foods rich in collagen because modern diets lack it compared to traditional nose-to-tail eating.
    • 2 Sep 2026 · Collagen · recommends · YouTube ↗
      Recommends 15 grams of collagen before bed, as it provides 3 grams of glycine and supports connective tissue repair, which peaks during sleep, making it a good way to get glycine for testosterone production.
  • Dr. Eric Berg · Boswellia · recommends
    • 28 Jan 2026 · recommends · Podcast ↗
      Recommends Boswellia, stating it targets the 5-LOX pathway, also known as the backup inflammatory alarm system.
    • 6 Nov 2026 · Collagen · recommends · Podcast ↗
      Recommends focusing on collagen to support stronger bones if a neck hump is associated with osteoporosis.
    • 31 Oct 2026 · Collagen · recommends · Podcast ↗
      Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
    • 21 Oct 2026 · Collagen · recommends · YouTube ↗
      Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
    • 18 Oct 2026 · Collagen · neutral · YouTube ↗
      Mentions that grass-fed liver is loaded with collagen.
    • 4 Oct 2026 · Collagen · recommends · YouTube ↗
      States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
    • 25 Sep 2026 · Collagen · recommends · Instagram ↗
      Recommends increasing collagen intake because a lack of it can make it harder for the body to repair itself.
    • 19 Sep 2026 · Collagen · neutral · Instagram ↗
      Discusses collagen in relation to changes in joints, skin, hair, nails, and recovery, suggesting these could be signs of needing more collagen.
    • 16 Sep 2026 · Collagen · uses · YouTube ↗
      Uses one scoop of collagen in their coffee every single morning, noting that the average person needs between 10 and 15 grams minimum daily for benefits like improved joints, nails, hair, gut health, and youthful skin.
    • 15 Sep 2026 · Collagen · warns · Facebook ↗
      Warns against consuming collagen powder while fasting.
    • 13 Sep 2026 · Collagen · recommends · Facebook ↗
      Recommends increasing collagen intake instead of a glycine supplement, suggesting adding it to coffee or a shake and pairing it with vitamin C to support absorption.
    • 3 Jul 2025 · recommends · Podcast ↗
      Recommends Boswellia serrata as an amazing supplement that research has shown to be as effective as meds without side effects for joint pain.
    • 6 Jan 2023 · recommends · YouTube ↗
      Recommends Boswellia as a great COX 2 inhibitor that can mimic meds without the side effects.
    • 6 Feb 2022 · recommends · YouTube ↗
      Mentions a study showing that a combination of turmeric, spirulinum, and boswellia significantly reduced thyroid nodules.
  • Dave Asprey · Boswellia · recommends
    • 21 Oct 2025 · recommends · Podcast ↗
      Highlights a specialized blend of boswellia and celery seed for reprogramming inflammation.
    • 5 Nov 2026 · Collagen · uses · YouTube ↗
      States that no one used collagen for health; it was previously used as a packing aid for pills.
    • 27 Oct 2026 · Collagen · uses · YouTube ↗
      States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
    • 24 Oct 2026 · Collagen · recommends · Facebook ↗
      Recommends taking collagen for better skin health.
    • 10 Oct 2026 · Collagen · warns · YouTube ↗
      Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
    • 24 Sep 2026 · Collagen · neutral · Podcast ↗
      Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
    • 20 Sep 2026 · Collagen · neutral · YouTube ↗
      Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
    • 15 Sep 2026 · Collagen · uses · YouTube ↗
      Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
    • 9 Sep 2026 · Collagen · stopped · YouTube ↗
      Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
    • 3 Sep 2026 · Collagen · neutral · Podcast ↗
      Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
    • 3 Sep 2026 · Collagen · recommends · YouTube ↗
      Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
    • 21 Oct 2025 · uses · YouTube ↗
      Has used boswellia for many years and notes its positive effects on joints and even the brain, calling it a beautiful herb.
    • 31 Aug 2023 · recommends · YouTube ↗
      Agrees with the guest that boswellia would be beneficial for a dog with a spinal injury to mitigate inflammation and promote healing.
    • 30 Apr 2020 · recommends · YouTube ↗
      Dave Asprey suggests that if one could throw some Boswellia in, they would probably like it.
  • Siim Land · Boswellia · warns
    • 18 Aug 2024 · warns · YouTube ↗
      Experiences muscle pain from Boswellia, similar to berberine and meds.
    • 29 Oct 2026 · Collagen · recommends · Instagram ↗
      Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
    • 7 Oct 2026 · Collagen · recommends · Instagram ↗
      Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Collagen · neutral · X ↗
      Lists Collagen as one of 15 supplements backed by human studies.
    • 21 Sep 2026 · Collagen · uses · YouTube ↗
      Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
    • 8 Sep 2026 · Collagen · neutral · X ↗
      30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
    • 2 Sep 2026 · Collagen · recommends · YouTube ↗
      Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
    • 30 Aug 2026 · Collagen · neutral · Instagram ↗
      Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
    • 25 Aug 2026 · Collagen · neutral · X ↗
      Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
    • 21 Aug 2026 · Collagen · neutral · Instagram ↗
      Mentions that glycine makes up one-third of collagen.
    • 17 Aug 2026 · Collagen · recommends · X ↗
      Recommends taking Collagen one hour before exercise with a vitamin.
  • Ben Greenfield · Boswellia · neutral
    • 18 May 2024 · neutral · YouTube ↗
      Mentions Boswellia as another tool used to address inflammatory issues.
    • 22 Oct 2026 · Collagen · recommends · Facebook ↗
      Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
    • 22 Oct 2026 · Collagen · recommends · YouTube ↗
      Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
    • 4 Oct 2026 · Collagen · recommends · Facebook ↗
      Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
    • 27 Sep 2026 · Collagen · recommends · X ↗
      Recommends starting with collagen for body remodeling.
    • 26 Jul 2026 · Collagen · recommends · Instagram ↗
      A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
    • 12 Jul 2026 · Collagen · neutral · X ↗
      The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
    • 9 Jul 2026 · Collagen · recommends · YouTube ↗
      Recommends collagen for skin repair post-tattoo.
    • 23 May 2026 · Collagen · neutral · YouTube ↗
      Notes that collagen is not a complete protein, so while it can be added to things, it should not be relied upon as the sole protein source.
    • 18 Apr 2026 · Collagen · recommends · YouTube ↗
      Recommends collagen peptides or essential amino acids to support the dermal matrix that anchors hair follicles, considering them important for hair health.
    • 25 Mar 2026 · Collagen · uses · X ↗
      Takes 10 grams of collagen in the morning.
    • 16 Nov 2019 · uses · YouTube ↗
      Uses Boswellia as one of the tools to apply when an inflammatory issue is identified.
    • 13 May 2019 · recommends · YouTube ↗
      Recommends Kion Flex, a joint formula with proteolytic enzymes, Boswellia, hyaluronic acid, white willow bark, turmeric, and ginger, especially for injuries, nagging aches, and pains, to be taken on an empty stomach.
    • 2 Feb 2019 · recommends · YouTube ↗
      Recommends boswellia as a natural anti-inflammatory alternative to meds.
  • Dr. Mark Hyman · Boswellia · recommends
    • 17 Nov 2023 · recommends · YouTube ↗
      Recommends Boswellia as an anti-inflammatory herb.
    • 7 Oct 2026 · Collagen · neutral · Podcast ↗
      Dr. Hyman mentions collagen supplements in the context of skin aging.
    • 7 Oct 2026 · Collagen · recommends · YouTube ↗
      Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
    • 30 Sep 2026 · Collagen · uses · YouTube ↗
      Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
    • 19 Aug 2026 · Collagen · uses · YouTube ↗
      Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
    • 17 Aug 2026 · Collagen · neutral · YouTube ↗
      States that collagen powder may modestly improve elasticity and hydration of the skin.
    • 17 Aug 2026 · Collagen · neutral · Podcast ↗
      Notes that most people focus on collagen powders for skin aging, but healthy skin is built inside the body.
    • 7 Aug 2026 · Collagen · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 22 Jul 2026 · Collagen · uses · YouTube ↗
      Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
    • 10 Jun 2026 · Collagen · recommends · YouTube ↗
      Recommends supplementing with high-quality collagen because the body produces less after age 20, and it supports skin health and joint comfort.
    • 3 Jun 2026 · Collagen · recommends · YouTube ↗
      Recommends supplementing with high-quality collagen, as it is the most abundant protein in the body, supporting skin, joints, bones, and connective tissues, and its production decreases after age 20.
  • Bryan Johnson · Collagen · uses
    • 6 Nov 2026 · uses · YouTube ↗
      Bryan Johnson states that he eats collagen peptides.
    • 22 Oct 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 22 Jul 2026 · uses · X ↗
      Consumes collagen peptides at 4:55 am.
    • 1 Jul 2026 · uses · X ↗
      Uses collagen peptides as an ingredient in Nutty Pudding.
    • 4 May 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 2 May 2026 · uses · X ↗
      He takes 10 g of Collagen in the morning for muscle.
    • 21 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for skin health.
    • 15 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 14 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 8 Apr 2026 · uses · X ↗
      Takes 10 grams of collagen in the morning for muscle.
  • Dr. Rhonda Patrick · Collagen · stopped
    • 5 Aug 2025 · stopped · Podcast ↗
      Is no longer taking collagen.
    • 3 Jul 2025 · uses · Facebook ↗
      Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
    • 28 Apr 2025 · recommends · YouTube ↗
      Dr. Rhonda Patrick, who was previously unconvinced, now recommends hydrolyzed collagen powder prophylactically for connective tissue and ligaments, especially if someone has a soft tissue injury history, to be taken 30 to 60 minutes pre-exercise with 50 milligrams of vitamin C.
    • 22 Apr 2025 · neutral · Podcast ↗
      Discusses whether collagen can actually strengthen tendons.
    • 5 Dec 2024 · warns · YouTube ↗
      Warns that collagen is a suboptimal protein choice for those engaged in resistance training and wanting to improve skeletal muscle protein synthesis because it does not significantly enhance muscle protein synthesis or muscle connective protein synthesis at rest or after exercise.
    • 30 Jul 2024 · neutral · Instagram ↗
      Discusses whether collagen supplementation benefits the skin.
    • 30 Jul 2024 · neutral · YouTube ↗
      Suggests that collagen might be more relevant for tissues like cartilage, bone, tendons, ligaments, and skin, which are more than 80% collagen, especially after surgery where collagen structures need to be renewed.
    • 15 Jan 2024 · uses · Instagram ↗
      Includes 2 scoops of Great Lakes collagen powder in her smoothie recipe, which she describes as packed with micronutrients.
    • 29 Jun 2022 · neutral · YouTube ↗
      Suggests that collagen's notoriety in supplemental form for athletes may stem from its ability to stimulate collagenous tissue synthesis, which strengthens tendons and collagenous proteins within muscles.
    • 30 May 2016 · uses · YouTube ↗
      Dr. Patrick adds a quarter cup of hydrolyzed collagen powder to her smoothie, primarily for the non-essential amino acids like glycine and proline, which are necessary for collagen synthesis and wound healing.
  • Peter Attia · Collagen · neutral
    • 20 Jun 2024 · neutral · YouTube ↗
      Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
    • 3 Jun 2024 · warns · YouTube ↗
      Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
    • 28 Apr 2024 · warns · YouTube ↗
      Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
    • 22 Apr 2024 · warns · YouTube ↗
      States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
    • 26 Oct 2020 · recommends · YouTube ↗
      Recommends collagen supplements, in either pill or powder form, for hair, skin, nails, bones, and for putting on and maintaining healthy muscle, as it's difficult to get enough from diet alone.
    • 7 Jan 2020 · recommends · YouTube ↗
      Suggests throwing some collagen into the diet as a source of glycine.
    • Date not recorded · neutral · Website ↗
      Uses collagen as a classic example of an orally taken peptide that is regulated as a supplement, noting it's taken for its amino acid breakdown rather than the whole peptide.
    • Date not recorded · warns · Website ↗
      States there is no good evidence that collagen supplements marketed for "gum regrowth" can restore a receded gumline without surgery, though some may improve symptoms or slow progression.

RAL Summary

Members OnlyTier 3 for Joints and Mobility

Placed in tier 3 on reviews: 96 percent of 407 reviews are positive. Human studies back both ingredients at the doses in this product, including large pooled analyses for Boswellia [1] and a 40 milligram collagen trial [6].

Where the evidence disagrees: 5 of the 68 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Immune system

Combine with: To further enhance joint health and support, consider combining Boswellia with UC-II with Omega-3 fatty acids, known for their anti-inflammatory properties. Glucosamine and Chondroitin are also excellent additions as they provide building blocks for cartilage repair and maintenance. MSM (Methylsulfonylmethane) can support connective tissue health, while Turmeric (Curcumin) offers additional anti-inflammatory benefits. Vitamin D is crucial for bone health, which indirectly supports joint function.

Possible side effects: Pooled analyses found no added side effects with Boswellia compared with placebo, and undenatured type II collagen was well tolerated, with fewer side effects than a standard arthritis drug.

Supplement Facts

Boswellia Extract 500 mg · UC-II® Undenatured Type II Collagen 40 mg
Supplement Facts
Serving Size 2 Veggie Caps
Servings Per Container 30
Amount Per Serving% Daily Value
Boswellia Extract (Boswellia serrata) (gum resin) (40% boswellic acids)500 mg†
UC-II® Undenatured Type II Collagen40 mg†
† Daily Value not established.

Other ingredients: Microcrystalline cellulose, hypromellose (vegetarian capsule), magnesium stearate (vegetable source), silicon dioxide.

Directions: Adult Use: Take 2 capsules daily preferably on an empty stomach, or as recommended by a nutritionally informed physician.

Label source: Vitacost · Report a label change

Sizes and barcodes: 60 Veggie Caps, UPC 7 53950 00601 0 (on market)

Show entire label
The Doctor's Best Boswellia with UC-II label, 60 Veggie Caps
Boswellia with UC-II, 60 Veggie Caps

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Our articles on this subject

Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.