Doctor's Best Boswellia with UC-II Review
Doctor's Best Boswellia + UC-II Supplement, for Men & Women, is a 60 count bottle of Veg Caps listed on Amazon as a Boswellia Serrata Extract capsule for joint health support. The Amazon listing describes a unique blend that includes Boswellia and type II collagen, offered as a comprehensive formula for smooth and flexible joints. The product highlights say the formula supports joint comfort and mobility, and that by helping to maintain healthy cartilage, UC-II can help support joint health and mobility for an active lifestyle. According to the bullet points, Boswellia + UC-II Supplement provides 500 mg of Boswellia extract and 40 mg of UC-II (Undenatured Type II Collagen) per 2-capsule serving. The product is listed as gluten free, soy free, and non-GMO. The suggested use is to take 2 Boswellia serrata extract capsules daily, preferably on an empty stomach, or as recommended by a nutritionally informed physician. The listing states that the item is unflavored, has a Capsule item form, and comes in a bottle with 60 count. The product benefits section lists bone and joint support and immune support, and notes that boswellia supports the health of joint components called glycosaminoglycans, a group of molecules that provide lubrication for joints. The brand describes itself as having been dedicated to providing thoroughly researched, rigorously tested, and clinically approved supplements for over 35 years, and says good nutrition starts with sound science. The item is sold by Doctors Best and ships from Amazon. The listing notes that the item is non-returnable due to food safety reasons, though damaged or defective items may be refunded or replaced. The product's Amazon Best Sellers Rank is number 15 in Boswellia Serrata. The model number is DRB-00601 and the UPC is 753950006010.
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Study, Trial or Testing Result Summary
Members Only68 human studies · 56 improved
Both studied ingredients are present at or above the doses used in studies. Boswellia is given at 500 milligrams a day, more than the 100 milligrams that worked in trials. In a review of 49 trials, 90 days of 100 milligrams of an enriched extract cut knee arthritis pain by about 17 points on a 100-point scale and improved function compared with placebo [1]. A pooled analysis of 39 trials ranked Boswellia highest of seven supplements for pain and stiffness, with no added side effects [2], and another of 20 trials agreed [3]. In an 80-person trial, 180 days improved pain and function and increased cartilage thickness on scans [4]. One 30-day trial saw benefits by day 5 [5]. Undenatured type II collagen is given at 40 milligrams, the same dose that, over 180 days in 191 people with knee arthritis, eased symptoms more than placebo and more than glucosamine with chondroitin [6]. A pooled analysis of 23 trials ranked it among the top supplements for joint pain and function, though evidence quality was low [7]. In healthy active adults, 40 milligrams for 24 weeks improved knee bending more than placebo [8]. Benefits seen in the medium term were not clear in the long term [9]. Animal and cell studies are never counted.
See all 68 studies →Hide the studies
- In a review of 49 trials in people with osteoarthritis (5980 people overall), 90 days of 100 mg enriched Boswellia serrata extract cut pain by about 17 points on a 100-point scale and improved function compared with placebo.Oral herbal therapies for treating osteoarthritis.
- In a pooled analysis of 39 trials of 4599 adults with knee osteoarthritis across seven supplements, Boswellia improved pain, stiffness and function more than placebo and ranked highest for pain and stiffness, with no added side effects.Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.
- In a review of Ayurvedic treatments for osteoarthritis (2952 people overall), Boswellia serrata showed no significant effects once the risk of biased study methods was taken into account.Ayurvedic interventions for osteoarthritis: a systematic review and meta-analysis.
- In a pooled analysis of 23 placebo-controlled trials (2455 people with osteoarthritis), undenatured type II collagen and collagen ranked among the top supplements for reducing joint pain and improving function, though the evidence quality was low.Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis.
- In a review of herbal medicines for osteoarthritis (1741 people overall), Boswellia serrata from two trials worked better than placebo and valdecoxib for pain and physical function, though overall evidence quality was low.Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis.
- In a pooled analysis of 20 trials with 1633 people with knee osteoarthritis, modified Boswellia serrata formulations improved pain, stiffness and knee function compared with other treatments, with no difference in side effects.Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee ost…
- In a pooled analysis of 13 trials (up to 1185 people with knee osteoarthritis), the overall effect of Boswellia was not significant because the studies differed so much, but subgroup analysis showed lower joint symptom scores than placebo.Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta…
- In a pooled analysis of 11 trials with 1009 people with knee osteoarthritis, Boswellia and curcumin products relieved pain and improved function more than placebo with no safety differences, though study quality was low.Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.
- In a pooled analysis of 9 trials with 712 people with osteoarthritis, Boswellia serrata lowered pain, stiffness and function scores versus control, with the Aflapin extract showing larger reductions than other Boswellia products.Efficacy evaluation of standardized Boswellia serrata extract (AflapinⓇ) in osteoarthritis: A systematic review and sub-…
- In a pooled analysis of seven trials with 545 people with osteoarthritis, Boswellia and its extract reduced pain and stiffness and improved joint function compared with control, with at least 4 weeks of treatment recommended.Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis.
- In a pooled analysis of 69 trials of 20 supplements for hand, hip or knee osteoarthritis, Boswellia serrata extract had a large, clinically important short-term pain-reducing effect versus placebo, though evidence quality was very low.Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
- A review of seven randomized trials, including some in osteoarthritis and rheumatoid arthritis, found Boswellia serrata extracts were clinically effective in all trials with no serious safety issues, but the evidence was encouraging rather than compelling.Frankincense: systematic review.
- A review of randomized trials of complementary treatments for osteoarthritis found some consistent evidence that Indian Frankincense may be effective, though the number of trials was small.Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic r…
- A review of frankincense research reported that clinical trials showed benefit against osteoarthritis and other inflammatory conditions, with only mild side effects.Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
- A review of 19 studies of collagen in osteoarthritis and rheumatoid arthritis found most were of poor quality, with some reporting side effects and low efficacy versus routine treatments, so benefit or harm could not be decided.Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review.
- In a 6-month trial of 440 adults with knee osteoarthritis, an Ayurvedic herbal formula containing Boswellia significantly reduced knee pain and improved knee function, and performed about as well as glucosamine and a med.Read the study on PubMed (23365148) →
- In 274 people with rheumatoid arthritis, oral type II collagen for 24 weeks beat placebo at 20 mcg daily on only one of three response measures, with no treatment-related side effects.Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled…
- In 212 people with knee osteoarthritis, one daily capsule of an undenatured chicken type II collagen complex for 180 days reduced pain and stiffness and improved joint function more than placebo.[Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, d…
- In 201 adults with osteoarthritis, a curcumin product with 450 mg daily boswellic acid for 12 weeks improved joint pain and physical performance more than placebo, and was more effective than curcumin alone.Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, do…
- In 191 people with knee osteoarthritis, 40 mg daily undenatured type II collagen for 180 days reduced overall joint symptoms more than placebo and more than glucosamine plus chondroitin, and was well tolerated.Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a mu…
- In 162 adults with hand osteoarthritis, a combined turmeric and Boswellia tablet taken daily for 3 months reduced pain more than placebo, with a difference of 8.5 mm on a 100 mm scale, and no significant difference in adverse events.Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomize…
- In a 90-day placebo-controlled trial of 150 adults aged 40 to 75 with early knee osteoarthritis, BOSMAX Boswellia serrata extract significantly improved knee symptoms and lowered inflammatory markers compared with placebo.Clinical Benefits of Boswellia Serrata (BOSMAX®) in Early Knee Osteoarthritis: A Randomized, Placebo-Controlled, Double-…
- In an 8-week placebo-controlled trial of 120 adults over 40 with persistent knee pain, Boswellia extract alone improved sleep latency, while the Boswellia plus omega-3 combination improved quality of life, though pain reduction was shown mainly for the omega-3 product.Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Th…
- In 106 adults with hand osteoarthritis, a daily supplement containing 250 mg Boswellia serrata extract for 12 weeks did not reduce hand pain more than placebo.Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an intern…
- In 105 adults with knee osteoarthritis, 200 mg per day of an herbal blend containing Boswellia serrata gum resin for 90 days gave significant pain relief and better physical function compared with placebo, with benefit seen as early as 14 days.A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving J…
- In 100 Japanese adults with knee pain, a combination supplement including 45 mg type II collagen peptides for 16 weeks showed no overall difference from placebo, but gave greater walking speed and leg strength in subgroups with more knee pain.Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, p…
- In 96 healthy adults with activity-related joint discomfort, 40 mg of undenatured type II collagen daily for 24 weeks improved knee bending range more than placebo (3.23 vs 0.21 degrees).UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controll…
- In a multicenter trial of 88 adults with knee osteoarthritis, adding Loxacon capsules containing Boswellia to physical therapy roughly doubled functional improvement at 5 weeks and made clinical improvement about three times as likely.Investigating the Additive Effects of Loxacon® Food Supplement Capsules in Patients with Knee Osteoarthritis. A Multicen…
- In 84 adults with knee osteoarthritis, a daily complementary medicine combination containing 250 mg Boswellia serrata extract for 12 weeks relieved pain no better than placebo.Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, pl…
- In a placebo-controlled trial of 80 people with mild to moderate knee osteoarthritis, 100 mg daily of a standardized Boswellia extract for 180 days improved pain and joint function, increased cartilage volume and thickness on MRI, and lowered inflammatory and cartilage breakdown markers compared with placebo.A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with …
- In a 90-day placebo-controlled trial of 75 adults with knee osteoarthritis, 100 mg daily of 5-Loxin, a Boswellia extract, significantly reduced pain and improved physical function compared with placebo, and it was safe.A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthrit…
- In 75 adults with knee osteoarthritis, capsules of Elaeagnus fruit extract alone or with Boswellia resin extract for 4 weeks reduced pain and improved function about as well as a med, with no significant difference between groups.Read the study on PubMed (28349271) →
- In a placebo-controlled trial of 70 people with knee osteoarthritis, 100 mg of Aflapin daily for 30 days reduced pain and function scores and lowered inflammatory markers compared with placebo, with no significant adverse effects.Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Sh…
- In a 4-week placebo-controlled trial of 70 adults with knee osteoarthritis, a frankincense extract oil rubbed onto the knee three times daily reduced pain and improved function more than placebo.Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoa…
- In a randomized trial of 70 people with knee osteoarthritis, one daily capsule of Artneo for six months was not inferior to glucosamine and chondroitin for improving WOMAC scores, with a greater reduction in stiffness and synovitis on MRI but no difference in pain.[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins…
- In a placebo-controlled trial of 68 people with knee osteoarthritis, a 12-week combined collagen tablet improved pain and function over time, but it did not beat placebo, and no side effects were reported.Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a rand…
- In 64 healthy Japanese adults, 3.2 mg of undenatured type II collagen daily for 12 weeks improved knee flexibility, knee and lower back pain, and walking and stair-climbing performance compared with placebo.Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomi…
- In a placebo-controlled trial of 62 people with knee osteoarthritis, 90 days of Boswellia serrata gum resin (300 mg) combined with celery seed extract reduced pain, stiffness and swelling and lowered inflammatory and cartilage breakdown markers compared with placebo.Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degen…
- In a 90-day placebo-controlled trial of 60 adults with knee osteoarthritis, 100 mg daily of Aflapin, a Boswellia gum resin product, significantly reduced pain and improved physical function compared with placebo, with improvements seen as early as day 7.Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomiz…
- In a randomized, placebo-controlled trial of 60 people with knee arthritis, 60 days of boswellic acids (7.2 mg) with methylsulfonylmethane (5 g) daily did not improve pain or joint function beyond placebo and initially worsened pain, but it significantly reduced the need for meds.The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
- In a 30-day placebo-controlled trial of 60 adults with knee osteoarthritis, 100 mg daily of Aflapin, a Boswellia serrata gum resin extract, significantly reduced pain and improved physical function, with benefits seen as early as day 5.A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with o…
- In 60 people with early knee osteoarthritis, a daily tablet containing Boswellia serrata extract with hyaluronic acid improved knee scores and reduced pain over 3 months, similar to hyaluronic acid injections, though the study had no placebo group.Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis…
- In an 8-week placebo-controlled trial of 60 adults with mild to moderate knee osteoarthritis, 100 mg daily of a standardized Boswellia extract significantly reduced pain, stiffness and total WOMAC score, lowered high-sensitivity CRP, and was well tolerated.High potency and water dispersible Boswellia extract reduces pain and inflammation in subjects with osteoarthritis of th…
- In 60 people with severe active rheumatoid arthritis, oral chicken type II collagen for 3 months reduced swollen and tender joints while placebo did not, and four patients went into complete remission.Effects of oral administration of type II collagen on rheumatoid arthritis.
- In 55 healthy adults with exercise-related knee pain, 40 mg of undenatured type II collagen daily for 120 days improved knee extension compared with placebo and delayed the onset of joint discomfort during strenuous exercise.Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy…
- In patients with stage III knee osteoarthritis, one daily Artneo capsule containing undenatured chicken type II collagen for 180 days reduced pain and stiffness and improved joint function and quality of life more than placebo.[Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, …
- In a placebo-controlled trial of 48 people with knee osteoarthritis, 120 days of a Boswellia serrata extract reduced pain and stiffness and lowered high-sensitivity C-reactive protein compared with placebo, with no serious adverse events.A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serra…
- In a randomized, placebo-controlled crossover trial of 42 people with osteoarthritis, a three-month course of a herbal and zinc formulation containing Boswellia significantly reduced pain and disability scores compared with placebo, though X-ray changes were not significant.Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study.
- In 32 people with meniscus damage, eight weeks of a collagen supplement containing type II collagen reduced pain and improved quality of life more than placebo, though balance and most functional tests did not change.The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality…
- In an 8-week randomized crossover trial of 30 adults with knee osteoarthritis, Boswellia serrata extract reduced knee pain, improved knee flexion and walking distance, and decreased swelling compared with placebo, with no radiological change.Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind…
- In 30 people with knee osteoarthritis, a turmeric and Boswellia formulation at 500 mg twice daily was safe and gave better symptom scores than a med 100 mg twice daily.Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee o…
- In a double-blind trial of knee osteoarthritis over two months, both solid lipid Boswellia particles and standard Boswellia gum extract improved pain and WOMAC scores, but only the lipid form lowered inflammatory cytokines and reduced the need for rescue meds more.Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BS…
- In a randomized trial of people with knee osteoarthritis, undenatured type II collagen over 90 days cut pain and stiffness scores by about a third and improved daily function more than a glucosamine and chondroitin combination, which produced smaller gains.Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial.
- In 503 people with rheumatoid arthritis, 0.1 mg daily chicken type II collagen for 24 weeks reduced pain and joint counts, and 41.55% met the 20% improvement criteria, fewer than with a med (57.86%) but with fewer side effects.A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid a…
- In more than 260 people with rheumatoid arthritis, a special Boswellia extract called H15 reduced joint swelling, pain and stiffness compared with placebo, with the study duration not stated in the summary.Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis.
- In 236 people with rheumatoid arthritis, 0.1 mg daily chicken type II collagen for 24 weeks reduced pain and stiffness, and 68.57% met the 20% improvement criteria, fewer than with a med (83.02%) but with fewer side effects.A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumato…
- In 105 women aged 60 to 80 with knee osteoarthritis, adding undenatured type II collagen for 90 days reduced pain and stiffness and improved physical quality of life more than no collagen.UNDENATURED COLLAGEN TYPE II FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE.
- In an uncontrolled three-month study of 232 adults with hand osteoarthritis, a daily food supplement containing 120 mg Boswellia serrata resin and Curcuma longa reduced hand pain and the number of painful joints, and 64% of participants reduced their anti-inflammatory meds intake.Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial.
- In an uncontrolled six-week study of 153 adults with joint degeneration and muscle weakness, a topical herbal preparation containing Boswellia serrata lowered muscle enzyme levels and pain scores.Management of muscular dystrophy during osteoarthritis disorder: A topical phytotherapeutic treatment protocol.
- In a two-month study of 56 adults with osteoarthritis, 6 g daily of Boswellia serrata resin capsules, taken with or without a topical ointment, produced symptom improvement in both groups.Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis).
- In a pilot study of 49 adults with various forms of osteoarthritis taking a boswellia and bromelain supplement for 1 to 6 months, quality of life scores improved significantly at about 3 months, with no adverse events reported.Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients w…
- In an uncontrolled study of 20 people with rheumatoid arthritis, taking 0.5 mg of bovine tracheal type II collagen daily for 12 weeks led to clinical improvement in 18 of them, though a placebo effect cannot be ruled out.Treatment of rheumatoid arthritis by oral administration of bovine tracheal type II collagen.
- In a 14-day case study of 13 adults with chronic musculoskeletal pain taking a blend that included boswellia, pain scores fell from an average of 58 to 23 and movement ability improved, with no adverse effects reported.Five Herbs Plus Thiamine Reduce Pain and Improve Functional Mobility in Patients With Pain: A Pilot Study.
- In a small uncontrolled pilot of 10 children with juvenile rheumatoid arthritis, 12 weeks of oral chicken type II collagen reduced swollen and tender joints in 8 of the 10 children, with no treatment-related side effects.A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis.
- In a four-week registry of 55 adults with knee osteoarthritis, those taking a standardized Boswellia extract alongside standard care had greater improvements in pain, stiffness and walking distance than those on standard care alone.FlexiQule (Boswellia extract) in the supplementary management of osteoarthritis: a supplement registry.
- In a six-month registry of 54 adults with moderate knee osteoarthritis, those taking a Boswellia, ginger and glucosamine supplement alongside standard care had better function and walking distance, and lower inflammatory markers and reactive oxygen species.Movardol® (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: pre…
- In an observational study of 118 adults with painful knee osteoarthritis taking 1 to 4 capsules a day of a boswellia, turmeric and red algae blend for about 90 days, 64.5 percent were pain-relief responders by day 90, and 35.1 percent used meds versus 59.2 percent at baseline.Clusters of Responders and Predictive Factors for Response to Supplementation with Boswellia, Turmeric, and Red Algae Ex…
- In a small pilot of five women aged 58 to 78 with significant joint pain, 10 mg of undenatured type II collagen daily for 42 days significantly reduced pain, morning stiffness and loss of joint range of motion.Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic explo…
Review Totals and Summary
Members Only407 reviews · 96% positive
Doctor's Best Boswellia with UC-II capsules generally receive very positive feedback, with 100% of star ratings being 4 or 5 across approximately 406 total ratings. Buyers are largely satisfied, expecting and often experiencing benefits for joint health and mobility. **What it did** Many users report positive effects on joint health and comfort. One buyer "felt much better with my knee after 2 days," indicating quick relief. The product is described as helping to "effectively reduces inflammation" and supporting cartilage restoration. It also aims to "significantly improve mobility, reduce joint discomfort, and maintain joint flexibility." Another reviewer found it provided "Effective relief for joint pain." Overall, customers expect joint comfort and mobility benefits. **Complaints** There are no complaints about the product's effectiveness, taste, capsule size, or side effects in the provided feedback. Store summaries confirm this absence, noting no complaints about "taste, capsule size, or side effects." One store summary did observe a single lower rating among 27 total ratings on its page, but no details about the reason for that rating are available from customer feedback. **Taste, Smell, Pill Size, Form** The product comes in "good quality size 60 vegies" (vegetarian capsules). Reviewers appreciate the vegetarian form, noting that "Vegetarian capsules help significantly improve mobility." There are no complaints regarding the taste, smell, or size of the capsules. This summary focuses exclusively on feedback for the capsule form of the product, excluding any reviews or summaries pertaining to other forms like gummies or powders. **Value for Money** General satisfaction with the product's quality and value is a common theme among buyers. **Who it suits** The product appears suitable for individuals seeking support for joint health, mobility, and inflammation. It's seen as a "comprehensive solution for active longevity and musculoskeletal health." Some users purchased it on a doctor's recommendation, indicating professional endorsement for specific cases; for example, one buyer stated it "was recommended by doctor." While many report quick benefits, some new users are still assessing results over a longer period. No feedback suggests it did not suit anyone.
Biohacker Summary
Members Only8 of 10 recommend it
Five of the seven panelists who spoke about Boswellia, the main ingredient, recommend it, mostly as an anti-inflammatory; one of them says it has the most evidence of the supplements he named for recovering from brain injury, and two say it targets a separate inflammation pathway that curcumin misses. One pairs it with celery seed, one is neutral and simply calls it a tool for inflammatory issues, and one warns that it gave him muscle pain. No one gave a dose or a preferred form for Boswellia. Collagen is a smaller ingredient in this product, and most of the panel uses or recommends it, with typical doses of 10 grams a day, while one has stopped taking it and two doubt its value for building muscle.
See all 10 biohackers →Hide the biohackers
Andrew Huberman · Boswellia · recommends
- States that Boswellia, an Indian frankincense extract, has the most evidence among other supplements for TBI recovery, having shown some benefit in three clinical trials.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of collagen in the morning for muscle.
- Takes 10-20 grams of Collagen every day for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- He takes 10 grams of Collagen in the morning for skin health.
- Mentions Boswellia as having some potential benefit for inflammation, but notes it's not typically used unless in very specific circumstances like an injury.
Thomas DeLauer · Boswellia · recommends
- Recommends boswellia as a runner-up for inflammation, noting it inhibits 5-LOX, an enzyme targeting a separate inflammatory pathway that curcumin misses.
- Recommends taking collagen peptides in the morning for tendon tensile effects and 5 or 10 grams at night before bed to couple with the body's natural growth hormone pulse for skin and connective tissue repair.
- Would add more collagen to his protein shakes, believing it helps connective tissue protein synthesis and works synergistically with whey protein for muscle protein synthesis.
- Says he takes collagen to take care of his gut.
- Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
- Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
- Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
- Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
- Recommends taking 15 grams of collagen about 30 minutes before bed, especially on rest days, for its glycine content to aid sleep onset and for connective tissue repair.
- Recommends opting for foods rich in collagen because modern diets lack it compared to traditional nose-to-tail eating.
- Recommends 15 grams of collagen before bed, as it provides 3 grams of glycine and supports connective tissue repair, which peaks during sleep, making it a good way to get glycine for testosterone production.
Dr. Eric Berg · Boswellia · recommends
- Recommends Boswellia, stating it targets the 5-LOX pathway, also known as the backup inflammatory alarm system.
- Recommends focusing on collagen to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
- Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
- Mentions that grass-fed liver is loaded with collagen.
- States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
- Recommends increasing collagen intake because a lack of it can make it harder for the body to repair itself.
- Discusses collagen in relation to changes in joints, skin, hair, nails, and recovery, suggesting these could be signs of needing more collagen.
- Uses one scoop of collagen in their coffee every single morning, noting that the average person needs between 10 and 15 grams minimum daily for benefits like improved joints, nails, hair, gut health, and youthful skin.
- Warns against consuming collagen powder while fasting.
- Recommends increasing collagen intake instead of a glycine supplement, suggesting adding it to coffee or a shake and pairing it with vitamin C to support absorption.
- Recommends Boswellia serrata as an amazing supplement that research has shown to be as effective as meds without side effects for joint pain.
- Recommends Boswellia as a great COX 2 inhibitor that can mimic meds without the side effects.
- Mentions a study showing that a combination of turmeric, spirulinum, and boswellia significantly reduced thyroid nodules.
Dave Asprey · Boswellia · recommends
- Highlights a specialized blend of boswellia and celery seed for reprogramming inflammation.
- States that no one used collagen for health; it was previously used as a packing aid for pills.
- States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
- Recommends taking collagen for better skin health.
- Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
- Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
- Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
- Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
- Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
- Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
- Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
- Has used boswellia for many years and notes its positive effects on joints and even the brain, calling it a beautiful herb.
- Agrees with the guest that boswellia would be beneficial for a dog with a spinal injury to mitigate inflammation and promote healing.
- Dave Asprey suggests that if one could throw some Boswellia in, they would probably like it.
Siim Land · Boswellia · warns
- Experiences muscle pain from Boswellia, similar to berberine and meds.
- Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
- Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Collagen as one of 15 supplements backed by human studies.
- Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
- 30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
- Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
- Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Mentions that glycine makes up one-third of collagen.
- Recommends taking Collagen one hour before exercise with a vitamin.
Ben Greenfield · Boswellia · neutral
- Mentions Boswellia as another tool used to address inflammatory issues.
- Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
- Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
- Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
- Recommends starting with collagen for body remodeling.
- A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
- The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
- Recommends collagen for skin repair post-tattoo.
- Notes that collagen is not a complete protein, so while it can be added to things, it should not be relied upon as the sole protein source.
- Recommends collagen peptides or essential amino acids to support the dermal matrix that anchors hair follicles, considering them important for hair health.
- Takes 10 grams of collagen in the morning.
- Uses Boswellia as one of the tools to apply when an inflammatory issue is identified.
- Recommends Kion Flex, a joint formula with proteolytic enzymes, Boswellia, hyaluronic acid, white willow bark, turmeric, and ginger, especially for injuries, nagging aches, and pains, to be taken on an empty stomach.
- Recommends boswellia as a natural anti-inflammatory alternative to meds.
Dr. Mark Hyman · Boswellia · recommends
- Recommends Boswellia as an anti-inflammatory herb.
- Dr. Hyman mentions collagen supplements in the context of skin aging.
- Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
- Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- States that collagen powder may modestly improve elasticity and hydration of the skin.
- Notes that most people focus on collagen powders for skin aging, but healthy skin is built inside the body.
- Takes 10 grams of Collagen in the morning for muscle.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Recommends supplementing with high-quality collagen because the body produces less after age 20, and it supports skin health and joint comfort.
- Recommends supplementing with high-quality collagen, as it is the most abundant protein in the body, supporting skin, joints, bones, and connective tissues, and its production decreases after age 20.
Bryan Johnson · Collagen · uses
- Bryan Johnson states that he eats collagen peptides.
- Takes 10 grams of Collagen in the morning for muscle.
- Consumes collagen peptides at 4:55 am.
- Uses collagen peptides as an ingredient in Nutty Pudding.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 g of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of collagen in the morning for muscle.
Dr. Rhonda Patrick · Collagen · stopped
- Is no longer taking collagen.
- Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
- Dr. Rhonda Patrick, who was previously unconvinced, now recommends hydrolyzed collagen powder prophylactically for connective tissue and ligaments, especially if someone has a soft tissue injury history, to be taken 30 to 60 minutes pre-exercise with 50 milligrams of vitamin C.
- Discusses whether collagen can actually strengthen tendons.
- Warns that collagen is a suboptimal protein choice for those engaged in resistance training and wanting to improve skeletal muscle protein synthesis because it does not significantly enhance muscle protein synthesis or muscle connective protein synthesis at rest or after exercise.
- Discusses whether collagen supplementation benefits the skin.
- Suggests that collagen might be more relevant for tissues like cartilage, bone, tendons, ligaments, and skin, which are more than 80% collagen, especially after surgery where collagen structures need to be renewed.
- Includes 2 scoops of Great Lakes collagen powder in her smoothie recipe, which she describes as packed with micronutrients.
- Suggests that collagen's notoriety in supplemental form for athletes may stem from its ability to stimulate collagenous tissue synthesis, which strengthens tendons and collagenous proteins within muscles.
- Dr. Patrick adds a quarter cup of hydrolyzed collagen powder to her smoothie, primarily for the non-essential amino acids like glycine and proline, which are necessary for collagen synthesis and wound healing.
Peter Attia · Collagen · neutral
- Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
- Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
- Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
- States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
- Recommends collagen supplements, in either pill or powder form, for hair, skin, nails, bones, and for putting on and maintaining healthy muscle, as it's difficult to get enough from diet alone.
- Suggests throwing some collagen into the diet as a source of glycine.
- Uses collagen as a classic example of an orally taken peptide that is regulated as a supplement, noting it's taken for its amino acid breakdown rather than the whole peptide.
- States there is no good evidence that collagen supplements marketed for "gum regrowth" can restore a receded gumline without surgery, though some may improve symptoms or slow progression.
RAL Summary
Members OnlyTier 3 for Joints and Mobility
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Immune system
Combine with: To further enhance joint health and support, consider combining Boswellia with UC-II with Omega-3 fatty acids, known for their anti-inflammatory properties. Glucosamine and Chondroitin are also excellent additions as they provide building blocks for cartilage repair and maintenance. MSM (Methylsulfonylmethane) can support connective tissue health, while Turmeric (Curcumin) offers additional anti-inflammatory benefits. Vitamin D is crucial for bone health, which indirectly supports joint function.
Possible side effects: Pooled analyses found no added side effects with Boswellia compared with placebo, and undenatured type II collagen was well tolerated, with fewer side effects than a standard arthritis drug.
Supplement Facts
Boswellia Extract 500 mg · UC-II® Undenatured Type II Collagen 40 mg
| Boswellia Extract (Boswellia serrata) (gum resin) (40% boswellic acids) | 500 mg | † |
| UC-II® Undenatured Type II Collagen | 40 mg | † |
Other ingredients: Microcrystalline cellulose, hypromellose (vegetarian capsule), magnesium stearate (vegetable source), silicon dioxide.
Directions: Adult Use: Take 2 capsules daily preferably on an empty stomach, or as recommended by a nutritionally informed physician.
Label source: Vitacost · Report a label change
Sizes and barcodes: 60 Veggie Caps, UPC 7 53950 00601 0 (on market)
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Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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