Double Wood Supplements Serrapeptase Review
Serrapeptase is a proteolytic enzyme produced by silkworms with the main function of dissolving the silkworm's cocoon. It is most often supplemented to support joint health but has also been found to liquefy mucus and reduce the size of bacterial biofilms. This makes it helpful for reducing phlegm buildup and nasal discharge. The product carries a Notice that it contains soy and milk, and it is labelled gluten-free and non-GMO. The benefits listed on the page include reducing mucus production, where multiple studies are said to show the enzyme may decrease the viscosity of mucus and help nasal discharge. It is also described as supporting a healthy immune response, and as a systemic proteolytic enzyme that digests certain proteins. Each two capsule serving is stated to contain 240,000 SPU, with each bottle containing 60 servings, which is presented as a two month supply. The brand says it provides pure, potent supplements backed by careful sourcing and rigorous third-party testing. Directions recommend one to two capsules per day, which is 120,000 to 240,000 SPU, taken thirty minutes before eating or two hours after eating, and the page advises not to exceed three capsules per day. The certificate of analysis for lot 2611001 lists a capsule weight of 420 mg, a serrapeptase potency of 233,532 SPU against a specification of 216,000 to 360,000 SPU, a passed disintegration test within 30 minutes, heavy metal results well under limits, and passing microbial tests with E. coli, Salmonella and Staphylococcus aureus absent. The page notes the product is manufactured in an FDA-registered cGMP facility, in the USA from globally sourced materials, and that identity, potency and contaminants are verified per batch. A 30 day money back guarantee is offered. The current listing shows the single bottle as backordered and unavailable, though the price is listed at $19.95. The page also suggests pairing with magnesium products and offers a short frequently asked questions section about timing, dosage and use.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Lowest cost per month first, in stock, at 2 capsules a day. Checked Nov 8.
- iHerbLowest$17.11 a bottle$8.56/moBuy at iHerb (opens in a new tab)
- Double Wood Supplements$19.95 a bottle$9.98/moBuy at Double Wood Supplements (opens in a new tab)
Also at: Vitacost
Study, Trial or Testing Result Summary
Members Only2 human studies · 2 improved
Two small human studies tested serrapeptase for ankle joint injuries, and both found less swelling. In a 1989 randomized trial of 66 patients after surgery for a torn ankle ligament, those given serrapeptase had about half as much swelling by the third day. Groups using leg elevation and bed rest, with or without ice, had no reduction, and pain eased along with the swelling [1]. In a 2024 controlled trial of 76 adults with moderate ankle sprains, ten days of serrapeptase, taken as two 5 milligram tablets three times a day (30 milligrams a day), reduced ankle swelling more than paracetamol, while pain relief was similar in both groups [2]. Both studies were short and covered sudden ankle injuries, not long-term joint conditions such as arthritis [1][2]. This product lists its dose as 240,000 enzyme activity units a day rather than in milligrams, so it is unclear how it compares with the 30 milligram daily dose used in the 2024 study [2]. Animal and cell studies are never counted.
See all 2 studies →Hide the studies
- In 66 patients after surgery for a torn ankle ligament, those given serrapeptase had about 50% less swelling by the third day, while two groups using leg elevation and bed rest, with or without ice, had no reduction, and pain eased along with the swelling.[Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serra…
- In 76 adults with moderate ankle sprains, taking serrapeptase for ten days reduced ankle swelling more than paracetamol did, while pain relief was similar in both groups.Efficacy and safety of serrapeptase on ankle sprain cases: A single center prospective comparative study.
Review Totals and Summary
Members Only1,453 reviews · 90% positive
Across three online stores, Double Wood Supplements Serrapeptase has received a total of 54 ratings, with the following themes drawn from the written reviews visible on their pages, noting that some pages displayed only a handful of comments while others showed several. Customers frequently praise the Double Wood Supplements brand and the overall buying experience. Many reviewers highlight the efficiency of the ordering process, noting fast shipping and a good selection of products. The pricing is consistently described as reasonable or good, with some appreciating specific monthly deals that effectively make shipping free. A strong sense of trust in the brand is evident, with customers calling it a reliable go-to for supplements and a trusted name. Several individuals mention a long-standing relationship with the company, having purchased Serrapeptase and other supplements from Double Wood for several years, often describing them as the best product and price they have found. The ability to order directly from the company is also a valued aspect for many. Products are generally characterized as effective, clean, and dependable, with a preference expressed for simple, single-ingredient formulas without added extras. Regarding the effectiveness of the Serrapeptase capsules, a significant number of positive experiences are reported. Many users describe relief from joint discomfort and a reduction in arthritic pain. One reviewer noted it as a "behind the scenes benefit" for the body that improves with longer use. A specific and clear benefit was reported by one user for long-standing nasal congestion, who described it as one of their favorite supplements. While some reviewers expressed enthusiasm with simple comments like "awesome" or referred to it as a "gut cleaner," others who had only used the product for a few weeks indicated it was too early to judge full effectiveness but planned to continue taking it. However, some concerns and complaints were also raised. A notable point of uncertainty for some buyers is the product's potency; reviewers expressed a lack of clarity regarding the true potency or the optimal amount needed to be effective, leading them to simply hope it works. Delivery issues were also mentioned, with one customer reporting that their order did not arrive after thirty days and that they were still awaiting a promised refund. In terms of side effects, one reviewer reported a negative impact on alertness, stating that the product kept them awake. This individual's doctor had recommended the supplement for cholesterol, especially after nattokinase had caused tiredness, but the Serrapeptase had the opposite effect. No complaints were made regarding the taste or size of the capsules across the visible written reviews. The feedback consistently points to strong loyalty and satisfaction with the company and its pricing, alongside mixed confidence about effectiveness due to the lack of visible potency information, and occasional frustrations related to delivery and refund processes. The product appears to suit individuals seeking relief from joint pain, arthritis, and nasal congestion, and was also recommended by a doctor for cholesterol management.
Biohacker Summary
Members Only0 of 10 recommend it
Four of the ten panelists spoke about serrapeptase, the main ingredient, and all four recommend or use it. They take it mostly to break down scar tissue, unwanted proteins and biofilms, and some also take it to lower clotting or stroke risk, support joints, or help with floaters. One panelist describes taking about five big pills every night, roughly a million units, on an empty stomach, and says he has done this for 25 years, while another recommends high doses for yeast biofilms. Panelists pair it with antimicrobials, fasting, or a similar enzyme called nattokinase. No one reported a caution or said they stopped taking it.
See all 4 biohackers →Hide the biohackers
Dave Asprey · Serrapeptase · recommends
- Recommends serrapeptase, taking about five big pills every night, for people on the spectrum, as it digests gunk and protein debris in the blood, and he has been using it for 25 years.
- Has been taking serrapeptase at high doses for 25 years because it breaks up scar tissue in the body, and he takes about a million units every night on an empty stomach.
- For the last 25 years, Dave Asprey has been on a high dose of either serrapeptase or nattokinase to reduce stroke risk by breaking up thrombin and fibrinogen.
- Mentions serrapeptase as an example of a proteolytic enzyme that may reduce floaters.
- Advocates for taking Serrapeptase, an enzyme made by silkworms, and has been taking it for 25 years because it breaks down scar tissue and fibrosis in the body, which he identifies as one of the Seven Pillars of Aging.
- Has been taking Serrapeptase, a cousin of nattokinase, for 25 years because it breaks down stickiness in his blood, which was previously like sludge.
- Dave Asprey mentions that serrapeptase, as a proteolytic enzyme, is good for breaking down fibrogenicity and hard things like scar tissue formed around oxalate crystals.
- Mentions that there is some evidence that taking high-dose proteolytic enzymes like serrapeptase may reduce floaters over time.
- Recommends serrapeptase as a proteolytic enzyme to take during a fast to help the body break down waste proteins and scar tissue.
- Recommends serrapeptase, a digestive enzyme, for helping digest protein and potentially breaking up mucus.
Dr. Mark Hyman · Serrapeptase · uses
- Uses serrapeptase to break open bacterial biofilms, allowing antimicrobials to be more effective.
- Identifies serrapeptase as a common and important proteolytic enzyme to take during fasting to break up old tissues and scar tissue.
- Recommends serrapeptase as a common proteolytic enzyme to take during fasting for healing and breaking down old tissues.
Dr. Eric Berg · Serrapeptase · recommends
- Recommends serrapeptase as a supplement to prevent clotting.
- Recommends Serrapeptase, an enzyme created from silkworm bacteria, for breaking down unwanted proteins in the body.
- Dr. Berg recommends taking the enzyme serrapeptase.
- Recommends serrapeptase as a powerful enzyme to help break down scar tissue and unwanted proteins in the body, which can be a problem after gastric bypass.
- Mentions an enzyme called Serrapeptase that can be taken to improve cirrhosis.
- Recommends Serrapeptase for cirrhosis, suggesting a dose of 200,000 IUs taken three times per day on an empty stomach, noting its ability to get rid of scar tissue.
- Recommends taking serrapeptase at 200,000 IUs on an empty stomach, calling it a powerful protein enzyme that cleans and liquefies mucus in the sinuses and is good for the lungs, sinus issues, and sleep apnea.
- Recommends Serrapeptase, a powerful proteolytic enzyme, for Parkinson's disease, suggesting taking two on an empty stomach three times a day.
- Dr. Berg recommends Serrapeptase as a powerful enzyme for fluid retention, suggesting a dose of 120,000 to 250,000 international units taken several times a day on an empty stomach to dissolve scar tissue, improve circulation, help inflammation, and repair the liver and kidney.
Ben Greenfield · Serrapeptase · recommends
- States that serrapeptase is perfect for cleaning up arteries and deteriorated blood cells that can act like a biofilm, which helps with parasites.
- Recommends high-dose serrapeptase as a proteolytic enzyme to break down candida and yeast biofilms.
- Ben Greenfield mentions Serrapeptase as an ingredient in Kion Flex.
- Recommends serrapeptase for joint support, explaining that it finds hot spots in joints, eats scar tissue, and breaks it down, leading to structural remodeling of the joints.
- Ben discusses the advantages and disadvantages of daily intake of Serrapeptase for recovery, athletic performance, and protein absorption, noting an increase in people at the gym talking about it for quicker recovery.
- Ben discusses Serrapeptase, a microorganism from silkworm intestine used in alternative medicine for pain and inflammation, but states he hasn't found randomized controlled trials or evidence of its effectiveness, preferring proven proteolytic enzymes or natural anti-inflammatories instead.
RAL Summary
Members OnlyTier 4 for Joints and Mobility
The review summary is mostly seller feedback about shipping, pricing, ordering and refunds, and it counts 54 ratings across three stores, which does not match the 121 reviews behind the grade, so the review count cannot be taken as reviews of this product. Its reviews are set aside, so it is graded on its studies alone. Human studies support Serrapeptase (2 of 2 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Immune system
Combine with: To enhance the benefits of Serrapeptase for joint health, consider combining it with supplements that support cartilage integrity and further reduce inflammation. Glucosamine and Chondroitin are excellent choices for rebuilding and maintaining joint cartilage. MSM (Methylsulfonylmethane) can help reduce pain and inflammation while supporting connective tissue. Omega-3 fatty acids, such as those found in fish oil, provide broad anti-inflammatory support. Turmeric or Curcumin is another powerful natural anti-inflammatory that can work synergistically. Finally, Collagen peptides can help provide the building blocks for healthy joint tissue.
Possible side effects: The studies reported no side effects. One reviewer said it kept them awake.
Supplement Facts
Serrapeptase 240000 SPU
| Serrapeptase | 240,000 SPU | † |
Other ingredients: Hypromellose (capsule), Rice Flour, Magnesium Stearate and Silicon Dioxide.
Directions: Suggested Use: Take 2 capsules per day. For best results take 30 minutes before a meal or 2 hours after a meal.
Label source: Doublewoodsupplements · Report a label change
Show entire label
More joint health products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Natural Remedies for Joint Pain and Inflammation: What the Evidence SupportsArticle · Oct 23, 2026
- Fish Oil vs Krill Oil: Which Omega-3 Is Worth It?Article · Nov 10, 2026
Graded October 27, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings