Dr. LaMar's Products Serrapeptase Review

Serrapeptase (also called serratiopeptidase) is a proteolytic enzyme originally isolated from Serratia E15, a bacterium found in the intestine of silkworms. The silkworm uses the enzyme to dissolve its cocoon when it emerges. Serrapeptase supplements are sold as capsules, usually 40,000 to 120,000 SPU (serrapeptase units) each. Manufacturers use fermentation to produce the enzyme. This description covers the ingredient in general. I could not verify the specific formula, potency or capsule design of Dr. LaMar's Products Serrapeptase. Serrapeptase is a metalloprotease that depends on zinc to work. It breaks the peptide bonds in proteins and cuts large protein chains into smaller fragments. Researchers think this underlies its main proposed effects: - **Anti-inflammatory action.** The enzyme may break down inflammatory mediators and the protein-rich exudate that builds up at sites of swelling. This is thought to reduce swelling and ease the pressure that causes pain. It may also change the activity of inflammatory signaling molecules such as cytokines. - **Mucus thinning.** Serrapeptase may reduce the viscosity and elasticity of airway mucus. This is why it has been studied in chronic bronchitis and sinus congestion. - **Fibrin and dead-tissue breakdown.** The enzyme can digest fibrin, non-living tissue and some scar-related proteins. Healthy living tissue is thought to be left alone. This is the basis for claims about scar tissue and circulation, and for interest in using it together with nattokinase. - **Biofilm disruption.** Laboratory work suggests it may weaken bacterial biofilms. This could help meds reach bacteria, but the evidence comes from lab studies, not large human trials. Serrapeptase is destroyed by stomach acid, so absorption depends on how it is delivered. Most quality products use enteric-coated or delayed-release capsules so the enzyme survives until it reaches the small intestine. It is best taken on an empty stomach, at least 30 minutes before food or 2 hours after, so that it acts as a systemic enzyme and isn't used up digesting food protein. Typical label directions are one to three capsules daily. Clinical evidence is limited and mixed. Some small trials found less pain and swelling after dental surgery and in conditions such as ankle sprain or breast engorgement. Other studies were small, older or poorly controlled. Serrapeptase is sold as a dietary supplement and is not approved to treat any disease. Its proteolytic and fibrin-dissolving action means people on meds, people with bleeding disorders and people facing surgery should speak to a clinician first. Reported side effects include stomach upset and, rarely, allergic reactions. Check the label for the potency in SPU, the enteric coating, the capsule type (vegetarian or gelatin) and any third-party testing.