Dr. Mercola Biodynamic Organic Pomegranate Peel Review
Dr. Mercola Organic Biodynamic Pomegranate Peel Tablets 60 is presented as a concentrated source of polyphenol antioxidants taken from the peel of organically grown, Demeter-certified biodynamic pomegranates. The product page states the tablets are designed to bypass the sugars and bitterness found in pomegranate juice, and that the formula contains only the peel of the fruit, which is described as naturally rich in antioxidant compounds. The headline claims are antioxidant-rich support for mitochondrial and brain health, support for mitochondrial function, help to combat oxidative stress, and promotion of cognitive wellbeing. The page lists the product under the tags Antioxidant, Anti-Inflammatory and Vegetarian, and states that it features organic biodynamic pomegranate peel extract, is free from soy, gluten, GMOs and added sugars, has no bitter taste or juice-based sugar content, and is suitable for vegetarians. A key ingredient section describes the organic pomegranate peel extract as rich in polyphenols and flavonoids that support antioxidant defence and mitochondrial health. The stated directions for adults are to take 2 tablets daily with food or as recommended by a healthcare professional. The safety section advises consulting a healthcare practitioner before use if pregnant, breastfeeding, taking medication, or under medical supervision, notes the product is not intended for children, and says the recommended dose should not be exceeded. The nutrition section states that the product does not contribute significant amounts of vitamins or minerals with established UK NRVs, but provides a high dose of antioxidant-rich polyphenols from pomegranate peel extract. The ingredients are listed as Biodynamic Organic Pomegranate (Punica granatum) Peel Powder with other ingredients of Organic Gum Acacia and Organic Tapioca Maltodextrin. The page type is listed as tablet, with gluten and soy as free-from allergens, unisex gender, and suitability for vegetarians across the age ranges 15-35, 36-49 and over 50. A disclaimer states the product is not intended to diagnose, treat, cure or prevent any disease, that results may vary, and that manufacturers may alter ingredient lists, so buyers should check the bottle. The page also flags the item as a discontinued product and shows it as out of stock, offering a back-in-stock notification subscription instead. The one-time special price is shown as US$27.36 against a regular price of US$32.19, and a subscribe and save option is shown at US$25.99 with a five percent saving. Free delivery is mentioned, along with the earning of 20 reward points on the purchase.
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Study, Trial or Testing Result Summary
Members Only10 human studies · 6 improved
This product gives 750 mg of pomegranate peel powder a day, above the 500 mg used in the one trial of peel extract. In that trial, 60 adults with type 2 diabetes who took the extract for 8 weeks had lower inflammation and oxidative stress and higher antioxidant capacity than those on placebo [1]. Two trials in 120 men each found better hand-grip strength, and in one better walking distance, but they tested a blend of pomegranate rind and cocoa extract, not peel alone [2][3]. Pooled analyses of trials using various pomegranate products found that some antioxidant markers rose and one marker of fat damage fell, while other markers did not change, and the evidence was rated low [4][5]. Another pooled analysis of seven trials in 350 adults with diabetes found no clear change in inflammation or antioxidant capacity [6]. No study measured biological age or DNA repair directly. Animal and cell studies are never counted.
See all 10 studies →Hide the studies
- Across seven trials with 350 adults with type 2 diabetes, pomegranate supplementation did not significantly change blood sugar, blood fats, inflammation or antioxidant capacity compared with controls.The effect of pomegranate (Punica granatum) supplementation on metabolic status in patients with type 2 diabetes: A syst…
- Across 21 randomized trials, pomegranate raised total antioxidant capacity and superoxide dismutase and lowered a fat-damage marker (MDA) compared with controls, but did not significantly change several other oxidative stress markers.Does pomegranate consumption improve oxidative stress? A systematic review and meta-analysis of randomized controlled cl…
- In a pooled analysis of randomized trials lasting 3 weeks to 12 months, pomegranate significantly raised two antioxidant markers and lowered one fat-damage marker, but did not significantly change others; the authors rated the evidence as low.Is Consumption of Pomegranate Supplementation Effective on Oxidative Stress Biomarkers Including MDA, ox-LDL, POX 1, GPX…
- In seven trials of hemodialysis patients, different pomegranate parts including peel extract may have lowered blood pressure, oxidative stress and inflammation and improved blood fats, but the number of studies was limited.The effect of pomegranate consumption on cardiovascular risk factors in hemodialysis patients: A systematic review of cl…
- In a review of seven studies including five clinical trials in people with arthritis, pomegranate lowered inflammation markers and joint symptom scores and raised antioxidant capacity, though the evidence certainty was low to very low.Pomegranate (Punica granatum) as an adjunctive therapy in rheumatic diseases: A systematic review.
- In 120 healthy men aged 36-55, 200 or 400 mg daily of a pomegranate rind and cocoa extract blend for 56 days reduced aging male symptom scores, raised testosterone, and improved hand-grip strength and stress compared with placebo.A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' …
- In 120 men aged 40-70 with mild to moderate erectile dysfunction, 400 mg daily of a pomegranate rind and cocoa extract blend for 84 days improved sexual function, fatigue, six-minute walk distance and hand-grip strength compared with placebo.A Combination of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts Enhances Sexual Function in Aging Males in…
- In 80 healthy adults, a daily 50 ml fermented pomegranate drink for 8 weeks improved skin moisture, brightness, elasticity and collagen density compared with baseline, and a serum used for 4 weeks gave slight skin improvements.Fermented pomegranate extracts protect against oxidative stress and aging of skin.
- In 60 adults with type 2 diabetes, 500 mg a day of pomegranate peel extract for 8 weeks lowered inflammation markers and oxidative stress markers and raised total antioxidant capacity compared with placebo.A prospective, randomized, double-blind, placebo-controlled trial of polyphenols on the outcomes of inflammatory factors…
- In young healthy men, 240 ml of pomegranate juice daily for 2 weeks raised antioxidant enzyme levels and lowered a marker of oxidative damage after severe exercise compared with the water control group.Punica granatum juice effects on oxidative stress in severe physical activity.
Review Totals and Summary
Members OnlyWhat buyers say
Public customer feedback on this product is sparse. The Amazon Singapore and Australia listings show about 45 global ratings, and Evitamins shows none. The themes below come from the small number of written reviews I could read, so treat them as tentative. Most buyers who write in are positive, and the positives are mostly short and practical. One reviewer called the product "Strong", suggesting they felt it was potent. Another said they needed to reorder, which points to repeat purchasing. A third said their husband likes it, so some households use it as a shared daily supplement. Several buyers connect the tablets to cardiovascular benefits. One reviewer reported that their blood pressure seemed lower. They also hedged with a title saying it was too early to tell and gave four stars rather than five. That cautious tone is typical: people want the heart and mitochondrial benefits, but few claim dramatic or fast results. Because the benefits are gradual and hard to perceive, reviewers have little concrete to praise beyond general satisfaction. The main complaint I found concerns freshness and quality control. One international reviewer said the pills looked as though they could be old. They worried that, if so, the peel's beneficial effects might be gone. This fits a wider concern with imported supplements bought from third-party sellers. Buyers outside the US may receive stock with unclear dating. Third-party sellers also charge very high prices. One Australian listing showed an offer of over $178 for a related Mercola item, and others were around $45. The complaint is mainly about price and the reliability of the seller, not about the product's formula. I found no recurring complaints about taste, swallowing difficulty or digestive upset in the readable reviews. Retailers highlight the tablet form as avoiding the bitterness of juice. I also found no widespread reports of side effects, though the sample is too small to rule them out. Overall, the feedback is favorable but thin. Customers value the organic and biodynamic sourcing, the potency, and the convenience of a daily tablet. They are cautious about whether they can feel measurable benefits, and they worry about the freshness of stock from marketplace sellers. About 74% of the Amazon ratings are five stars, but the review text is too limited to support firm conclusions. For fuller detail, readers should check the Amazon and Desertcart review sections directly.
Biohacker Summary
Members Only5 of 10 recommend it
The panel is split on pomegranate, the main ingredient here: of ten biohackers only seven spoke about it, with two using it, one recommending it, one stopping, and three staying neutral. Those who like it cite heart and blood pressure support, nitric oxide, antioxidants, and feeding gut bacteria that turn its compounds into urolithin A, and they mostly favor whole seeds or juice, with one using 60 mL of juice and another 1 tablespoon. One panelist backed powdered peel, saying it is very bitter and should be taken in capsules. The main caution is that only some people have the gut bacteria to make urolithin A, so several say pomegranate or cheap extract may not work for everyone and that you would need huge amounts of fruit to match a direct supplement. One person stopped eating it because of sore joints, which they tied to its oxalates and sugar.
See all 8 biohackers →Hide the biohackers
Thomas DeLauer · Pomegranate · neutral
- Explains that Urolithin A is derived from pomegranates, but eating pomegranates does not provide the same absorption of Urolithin A as a pure supplement.
- Recommends consistently eating whole pomegranate pearls, rather than just the juice, because the fiber feeds the gut bacteria necessary for Urolithin A conversion, gradually shifting the microbiome towards greater production.
- Recommends consuming pomegranates consistently, even daily, to develop the gut bacteria, specifically Akkermansia, that can extract Urolithin A from them.
- Recommends pomegranate for lung health, noting that ellagitannins provide airway antioxidant defense.
- Recommends pomegranates to support specific bacteria that produce butyrate.
- Rates pomegranate arils as a 9.5, mentioning that punicalagins are converted into urolithin A by the gut, providing a super cool overall benefit.
- Notes that Urolithin A is normally produced in the gut when bacteria metabolize polyphenols from specific foods like pomegranate, but over 60% of people cannot efficiently convert pomegranate into Urolithin A.
- Recommends pomegranates for the lungs, stating that ellagitannins help protect against particles.
- Recommends pomegranates for gut barrier integrity, noting that their polyphenols interact with signaling pathways to support intestinal integrity, and even small, consistent exposure, like a tablespoon a week, can be beneficial.
- Recommends pomegranate extract as a source of Urolithin A, which signals for autophagy, but notes that conversion to usable Urolithin A might not always occur.
Ben Greenfield · Pomegranate · neutral
- Questions the efficacy of pomegranate extract for plaque melting, asking how an enzyme can get through stomach acid and if the gut bacteria can utilize its chemical trash to make K.
- Mentions pomegranates as a food that increases angiogenesis, as outlined in Dr. William Lee's book 'Eat to Beat Disease'.
- Notes that 1,000 mg of urolithin A is equivalent to juicing 60 pomegranates, which would also result in a lot of sugar.
- Mentions that daily pomegranate juice has been shown in clinical research to slow arterial plaque progression and support healthy blood pressure.
- Revisits the powerful heart-protective hack of adding pomegranate juice to one's routine to help reduce arterial plaque and lower blood pressure.
- Recommends consuming 50 ml of pomegranate juice daily for plaque reduction, lower blood pressure, and reduced LDL oxidation, citing studies showing it can reverse plaque accumulation and improve antioxidant status.
- Mentions that pomegranate was known as the royal fruit of the Bible and that the average pomegranate contains 613 seeds, the same number of commandments in the Old Testament.
- Mentions that juicing 30 pomegranates would provide 500 milligrams of Urolithin A, highlighting the impracticality of getting sufficient amounts from food alone due to the high sugar content and effort involved.
- Recommends pomegranate juice as a nitrate-rich food that converts into nitric oxide.
- Mentions pomegranates as a sirtuin that might contribute to anti-aging by upregulating the body's own reactive oxygen species defense mechanisms.
Dave Asprey · Pomegranate · stopped
- Would have to eat a ridiculous pile of pomegranates every day to get enough Urolithin A, and they are not doing that.
- Notes that pomegranates contain compounds that gut bacteria convert into urolithin A, which activates mitophagy through a unique biological pathway.
- Dave notes that eating pomegranates or taking cheap pomegranate extract does not work for most people to produce urolithin A.
- Dave Asprey used to eat pomegranates from his backyard tree but would get sore joints because pomegranate seeds have a lot of oxalates and sugar.
- Discusses the massive problem with trying to get Urolithin A from pomegranates, as only 30% of people have the right gut bacteria to even make it.
- Mentions that one would need six cups of pomegranate juice a day to hit the minimum effective dose of Urolithin A.
- Notes that pomegranates have been used by Persian and Greek doctors for thousands of years to improve vitality, and modern science is finally catching up to why.
- Notes that pomegranates have been associated with longevity and ancient doctors used them to improve vitality, but only about 30% of people can produce urolithin A from them.
- Mentions that pomegranate juice is another substance that can reverse plaque.
- Warns that drinking pomegranate juice to get enough urolithin A is not effective due to the high sugar content and the fact that 60-70% of people lack the necessary gut bacteria to convert it.
Dr. Eric Berg · Pomegranate · recommends
- Recommends pomegranate seeds as a top food to help increase nitric oxide.
- Recommends consuming pomegranate seeds to increase nitric oxide.
- Recommends pomegranate seeds as a potent heart healer, especially for decreasing the risk of plaque, supercharging nitric oxide, and helping to reduce blood pressure.
- Recommends pomegranates as they are rich in ellagic acid, known for its anticancer properties, protecting DNA from damage and decreasing inflammation and oxidative stress.
- Recommends consuming pomegranate for its polyphenols to help detoxify aldehydes.
- Recommends pomegranate for its compound that reduces inflammation, helps mitochondria, and inhibits the spread of cancer.
- Recommends pomegranate for decreasing inflammation and preventing fat from accumulating in the liver.
- Recommends pomegranates for their ellagic acid, which has anti-cancer properties, protects DNA from damage, and decreases inflammation and oxidative stress.
- Recommends pomegranate seeds, noting they are loaded with phytonutrients, including one that helps support collagen, and expresses a personal liking for them.
- Recommends pomegranate, noting that its phytochemicals can mimic the body's estrogen in a positive way and help balance estrogen by blocking bad estrogen.
Dr. Rhonda Patrick · Pomegranate · neutral
- Explains that pomegranate contains polyphenols called ellagitannins, which gut bacteria convert into Urolithin A, but there's significant individual variation in how much Urolithin A people actually produce from eating it.
- Some people produce urolithin A after eating pomegranates and walnuts, but others need to supplement directly.
- Recommends eating pomegranate, especially the arils and the bitter pith, as it is the best source of ellagitannins, which are precursors to urolithin A, and the food matrix improves bioavailability and increases beneficial gut bacteria.
- Dr. Rhonda Patrick notes that pomegranates are foods rich in ellagitannins, which gut microbes can convert into urolithin A.
Bryan Johnson · Pomegranate · uses
- Uses pomegranate juice as an ingredient in Nutty Pudding.
- Uses pomegranate seeds because they have unique polyphenols that protect cholesterol from oxidation, which improves blood flow.
- Finishes his Nutty Pudding with 60 mL of pomegranate juice for antioxidants and heart health.
- Includes pomegranate juice in his Nutty Pudding, which he consumes an hour after his Super Veggie.
- Has pomegranate seeds in his fridge.
- Includes pomegranate juice in his 'Nutty Pudding' as part of his fat profile for the third meal of the day.
- Bryan Johnson uses 60 ml of pomegranate juice in his Nutty Pudding.
Dr. Mark Hyman · Pomegranate · neutral
- Mentions that pomegranate juice has been known for a long time to be healthy and confer health benefits, but the mechanism was not clear until ellagitannins and their metabolism into urolithin A by the microbiome were discovered.
- Mentions that pomegranate has super beneficial effects on Akkermansia muciniphila, a keystone species that protects the gut lining, prevents leaky gut, reduces inflammation, and helps metabolic health.
- Uses pomegranates, specifically 1 tbsp of 100% pomegranate juice, for their polyphenols and beneficial phytonutrients without spiking blood sugar, to feed Akkermansia muciniphila.
- Was given pomegranate as part of a program to rehab his gut and rebuild bacteria.
- Dr. Hyman notes that pomegranates are a food containing polyphenols that the gut microbiome can convert into Urolithin A.
- States he took pomegranate in high doses every day in concentrates to regrow his Akkermansia when he had colitis.
- Recommends pomegranate powder as a prebiotic to feed probiotics and help rebalance the microbiome.
- Dr. Hyman explains that if one's gut microbiome can metabolize pomegranate ellagitannins, it produces Urolithin A, which has beneficial effects on rejuvenating and cleaning up mitochondria.
- Recommends pomegranate as an awesome food that helps blood flow and circulation.
- Mentions that his mother was given pomegranate juice and other foods to help grow good bacteria, which contributed to the successful elimination of her cancer through immunotherapy.
Siim Land · Pomegranate · uses
- Pomegranate seeds are one of Siim Land's go-to fruits.
- Loves pomegranates because they are loaded with urolithin, which she tries to get in food form for longevity.
- Lists pomegranate as a food that contains nitrates and helps with nitric oxide production.
- Mentions pomegranate as an example of a food containing dark phenols that helps glucose function.
- Recommends powdered pomegranate peels, rich in ellagic acid and ellagitannins, which convert to urolithin A by the microbiome, for profound benefits and autophagy activation, noting they are very bitter and should be capsuled.
RAL Summary
Members OnlyTier 4 for Healthy Aging
Tier 2 needs over 100 reviews with two thirds positive, but no reviews were counted, and the only trial of pomegranate peel itself is a single 8-week study in people with diabetes, while the blend trials and other pooled analyses mixed results. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 10 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Cardiovascular system, Muscular system
Combine with: Pomegranate peel is rich in ellagitannins (punicalagins) and polyphenols, which are converted by gut bacteria into urolithin A, a compound linked to mitophagy and mitochondrial renewal. This makes it a reasonable, though modest and indirect, fit for cellular aging support. It is not a proven DNA repair agent, and human evidence for reversing aging is limited. To strengthen the stack, consider pairing it with an NAD+ precursor such as nicotinamide riboside or NMN for sirtuin and DNA repair enzyme support, plus trans-resveratrol or quercetin for complementary antioxidant and longevity pathway activity. Liposomal glutathione or NAC supports the body's main endogenous antioxidant defenses. CoQ10 (ubiquinol) and PQQ support mitochondrial function, and omega-3 fish oil helps lower inflammation. A probiotic or prebiotic fiber can improve the gut microbial conversion of ellagitannins into urolithins. Taking it with a meal containing some fat may help tolerance, and anyone on meds or other medications should check with a clinician first.
Possible side effects: No major side effects reported.
Supplement Facts
Biodynamic organic Pomegranate peel powder 750 mg
| Biodynamic organic Pomegranate peel powder | 750 mg | † |
Other ingredients: Organic Gum Acacia, Tapioca Maltodextrin.
Directions: Suggested use: Adults, as a dietary supplement, take two (2) tablets daily, preferably on an empty stomach. Keep out of reach of children.
Barcode (UPC) 810487033626 · Label source: NIH label database · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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