Dr. Sinatra Advanced BP Support Review
Dr. Sinatra Advanced BP Support is a capsule supplement. A serving is 4 capsules, and each container holds 30 servings. Per serving, the label lists Magnesium 250 mg, Chinese Hawthorn Leaf Extract 600 mg, MegaNatural-BP 150 mg and PharmaGABA 50 mg. The other ingredients are gelatin, microcrystalline cellulose, maltodextrin, magnesium stearate and silica. The directions printed on the label, under Doctor's Suggested Use, say to take 4 capsules once daily with a meal. Buyers most often say their blood pressure readings came down or became steadier, some within a few weeks. A smaller group reports no change after a month or more.
Tier ⓘ
Tier 4 · Rank 7
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 7 within Tier 4 for Blood Pressure; 40 of 61 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
58 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
93% of 51
Biohacker Mentions
9 of 10
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Study, Trial or Testing Result Summary
Members Only85 human studies · 40 improved
14 of these 85 human studies gave the ingredient by drip or inhaler, not by mouth.
85 human studies40 improved29 no effect28,763 people studied
Grape seed extract, given here at a full dose, modestly lowered blood pressure in most studies. A pooled analysis of 16 trials found the top number fell about 6 points and the bottom number about 2.8 points [1], and a four-month trial found pressure returned to normal in most people taking 300 milligrams daily [2]. Other pooled analyses found smaller or one-sided drops [3][4]. Hawthorn reaches the studied dose at two servings a day. One trial in adults with type 2 diabetes found it lowered the bottom number but not the top number [5]. The calming compound in this product is at a full dose. Older trials found lower pressure [6][7], but newer trials found no change [8][9][10]. Magnesium is below the studied dose. In studies, about 365 milligrams a day lowered pressure by about 2 to 3 points [11][12]. The benefit showed mainly in people with uncontrolled high pressure [13], and one longer trial found no change [14]. Animal and cell studies are never counted.
See all 85 studies →Hide the studies
- Across 48 trials with 2719 people with heart disease or high blood pressure, grape seed extract lowered arterial stiffness (pulse wave velocity) compared with placebo, though no diet intervention significantly changed the augmentation index.Dietary strategies to combat arterial stiffness in cardiometabolic disease: a network meta-analysis.
- In 38 randomized trials of 2709 people taking a median 365 mg of elemental magnesium daily for a median 12 weeks, systolic blood pressure fell 2.81 mm Hg and diastolic 2.05 mm Hg versus placebo, with larger drops in people on meds or with low magnesium and no significant change in people with normal blood pressure.Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- In 34 placebo-controlled trials of 2028 adults taking a median 368 mg of magnesium daily for about 3 months, systolic blood pressure fell 2.00 mm Hg and diastolic 1.78 mm Hg versus placebo.Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Tr…
- In 23 randomized trials of 1345 people with type 2 diabetes, magnesium supplements were linked to lower diastolic blood pressure, but the abstract gives no figures for blood pressure, dose or duration.Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 D…
- In four studies of 1334 children with infantile epileptic spasms, adding magnesium sulfate to hormone therapy (ACTH) cut the rate of high blood pressure as a side effect compared with the hormone alone, though the studies were not about blood pressure in healthy people or treating it.Efficacy and tolerability of magnesium sulfate in children with infantile epileptic spasms syndrome: A systematic review…
- Pooling 16 trials with 810 people, grape seed extract lowered systolic blood pressure by about 6 mmHg and diastolic by about 2.8 mmHg, with larger effects in younger, obese or metabolic syndrome patients.The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials…
- Pooling 9 trials with 390 people, grape seed extract lowered systolic blood pressure by about 1.5 mmHg and heart rate by about 1.4 beats per minute, with no effect on diastolic pressure, cholesterol or inflammation.The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.
- Across 19 trials, grape seed extract lowered diastolic blood pressure by about 2.2 mmHg and heart rate by about 1.25 beats per minute, but did not significantly change systolic pressure or artery dilation.The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart r…
- This broad review of pre-eclampsia and high blood pressure in pregnancy lists magnesium supplementation among many treatments, but the abstract gives no results for magnesium.Pre-eclampsia, eclampsia, and hypertension.
- A review of double-blind trials lasting at least four weeks found magnesium supplements can help treat metabolic syndrome in people with low magnesium, with no specific blood pressure numbers given.Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.
- Across 49 trials, oral magnesium of at least 240 mg daily lowered blood pressure in people with uncontrolled hypertension on medication and over 600 mg daily was needed in untreated hypertension, while people with controlled blood pressure or normal blood pressure saw no change.Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials.
- A review of 20 grape seed extract studies found it may lower systolic and diastolic blood pressure in people with high blood pressure or metabolic syndrome.Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and B…
- In 10141 women with pre-eclampsia, magnesium sulphate cut the risk of eclampsia seizures by 58% versus placebo (0.8% vs 1.9%), though 24% reported side effects versus 5% on placebo; blood pressure itself was not reported as an outcome.Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-c…
- In 816 children with severe asthma in the emergency department, nebulized magnesium sulfate added to albuterol did not change systolic blood pressure or reduce hospitalization compared with placebo.Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asth…
- In a single-blinded controlled study of 430 adults, a magnesium-rich diet averaging about 1,142 mg a day for 12 weeks lowered total cholesterol, bad cholesterol and triglycerides by about 10% each, compared with a usual diet; blood pressure was not reported.Can dietary magnesium modulate lipoprotein metabolism?
- Over 10 years, 400 high-risk adults assigned to a magnesium-rich diet (about 1142 mg daily) had fewer heart complications and lower total and sudden death rates than those on their usual diet (about 418 mg daily).Effect of dietary magnesium supplementation in the prevention of coronary heart disease and sudden cardiac death.
- In 200 healthy first-time pregnant women, daily magnesium did not change the rise in blood pressure compared with placebo.Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study.
- In 194 pregnant women with preeclampsia treated for two weeks, adding a multivitamin to magnesium sulfate lowered blood pressure no more than magnesium sulfate alone.Effects of multivitamin combined with magnesium sulfate versus magnesium sulfate alone on hemodynamics, coagulation, and…
- In 182 women with severe preeclampsia, giving magnesium sulfate for 12 hours after delivery was as effective as 24 hours, with blood pressure similar in both groups.A comparison between the two methods of magnesium sulfate administration for duration of 12 versus 24 h after delivery i…
- In 164 overweight or slightly obese adults, 450 mg of magnesium daily as citrate, oxide or sulfate for 24 weeks did not change blood pressure or artery stiffness compared with placebo.Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized…
- In 150 pregnant women with chronic hypertension, a treatment plan that included magnesium orotate, along with other measures, reduced hypertension symptoms and supported a favorable pregnancy course.[Magnesium orotate in treatment of chronic hypertension in pregnant women].
- In 110 overweight pregnant women, a resveratrol and magnesium hydroxide complex with inositols for up to 60 days did not change systolic or diastolic blood pressure across groups, though lipid and glucose levels improved.Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant p…
- In 97 patients having bypass surgery, adding magnesium sulfate to heart-protecting cardioplegia fluid every 25 minutes protected the heart about as well as the standard every-15-minute method, with no difference in heart damage markers.The efficacy and safety of extending the ischemic time with a modified cardioplegic technique for coronary artery surger…
- In 96 middle-aged women with menopausal symptoms, grape seed extract at 100 or 200 mg daily lowered systolic and diastolic blood pressure after 4 weeks in a placebo-controlled trial lasting 8 weeks.Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters i…
- In 95 overweight adults, 360 mg of magnesium glycinate three times daily with vitamin D for 12 weeks raised vitamin D levels more than vitamin D alone, and lowered systolic blood pressure only in those whose baseline systolic pressure was above 132 mmHg.The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pre…
- In 88 patients having adrenal tumor surgery, magnesium sulfate infusion given before surgery cut the time blood pressure and heart rate stayed outside target ranges from 8.3% to 4.3% compared with placebo, with a lower peak systolic pressure.Efficacy and Safety of Preemptive Magnesium Sulfate Infusion during Pheochromocytoma and Paraganglioma Resection: A Rand…
- In 80 patients with organophosphorus poisoning, adding intravenous magnesium sulfate lowered diastolic blood pressure at 0 and 2 hours and lowered heart rate for up to 24 hours compared with saline, but systolic blood pressure did not differ.Therapeutic Effect of Adding Magnesium Sulfate in Treatment of Organophosphorus Poisoning.
- In 80 adults with high-normal blood pressure or borderline hypertension, GABA-rich Chlorella (20 mg GABA twice daily) for 12 weeks lowered systolic blood pressure more than placebo, with no adverse events.Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline h…
- In 79 adults with type 2 diabetes who were mostly on medication, 1200 mg of hawthorn extract daily for 16 weeks lowered diastolic blood pressure more than placebo, but did not lower systolic blood pressure more than placebo.Read the study on PubMed (16762125) →
- In 75 pregnant women with pregnancy-related hypertension, magnesium sulfate (20-25 g daily) served as the comparison group, and ligustrazine lowered mean arterial pressure more than magnesium sulfate did.[Treatment of hypertension syndrome of pregnancy with ligustrazine].
- In 70 untreated people with prehypertension or stage I hypertension, 300 mg daily of grape seed extract for 8 weeks did not significantly lower blood pressure compared with placebo.Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension…
- In 69 adults with treated high blood pressure, 1000 mg a day of grape-seed polyphenols alone did not significantly lower blood pressure over 6 weeks, and combined with vitamin C it raised blood pressure compared with placebo.The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-co…
- In 69 adults with treated high blood pressure, 1000 mg a day of grape-seed polyphenols alone for 6 weeks did not change blood pressure variation, but combined with vitamin C it increased variation.Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised contr…
- In 68 patients preparing for colonoscopy, a magnesium citrate drink taken before a lavage solution did not produce significant changes in heart rate or blood pressure compared with lavage alone or with bisacodyl.The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on ser…
- In 59 women treated for premature labor, bolus fenoterol caused fewer side effects, including blood pressure and heart rate effects, than continuous fenoterol, while the magnesium sulfate given in each arm was not the variable being tested.[Comparative study of maternal side effects of various forms of intravenous therapy with fenoterol in premature labor].
- In 55 healthy adults with high-normal blood pressure, 6 weeks of GABA-enriched cheese or low-fat milk did not change daytime blood pressure compared with a no-dairy diet.Effects of regular-fat and low-fat dairy consumption on daytime ambulatory blood pressure and other cardiometabolic risk…
- In 54 people with irregular heartbeats, a micronutrient combination for 6 weeks lowered fasting insulin and reduced heart muscle mass, with some signs of better heart filling, compared with placebo; blood pressure was not reported.Dietary intervention with a specific micronutrient combination for the treatment of patients with cardiac arrhythmias: t…
- In 27 adults with metabolic syndrome, 400 mg of oral magnesium daily for 12 weeks significantly lowered systolic blood pressure from about 135 to 126 mmHg and diastolic from about 84 to 79 mmHg, and also lowered interleukin-6, compared with a control group that took no magnesium.Positive effects of magnesium supplementation in metabolic syndrome.
- In 52 adults with prediabetes, 1500 mg of GABA daily for 95 days did not significantly change blood pressure or blood sugar response compared with placebo.Effects of γ-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized…
- In 50 newborns with birth asphyxia, magnesium sulfate infusion did not change blood pressure compared with saline placebo over the first 48 hours, although neurological outcomes at discharge were better.Short-term outcome of magnesium sulfate infusion in perinatal asphyxia.
- In a randomized, double-blind trial of 50 heart bypass patients, magnesium sulfate given for 5 days after surgery reduced atrial fibrillation (irregular heartbeat) to 4% of patients compared with 20% on placebo.Atrial fibrillation after coronary artery bypass surgery: predictors and the role of MgSO4 replacement.
- In 50 people with fatty liver disease, 520 mg a day of grape seed extract for 2 months lowered systolic, diastolic and mean blood pressure more than placebo.The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in…
- In 50 people with migraine, 200 mg a day of grape seed extract for 8 weeks lowered systolic blood pressure within the extract group, but the between-group difference was only reported as significant for a migraine-related blood marker, not blood pressure.Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quali…
- In a randomized, placebo-controlled trial of 48 women with mild preeclampsia after 34 weeks, magnesium sulfate lowered blood flow resistance in the baby's umbilical artery but did not change it in the baby's middle cerebral artery.Randomized controlled study comparing effect of magnesium sulfate with placebo on fetal umbilical artery and middle cere…
- In 45 patients with brain bleeding from a ruptured aneurysm, two weeks of intravenous magnesium sulfate shortened vasospasm but did not significantly improve outcomes or reduce cardiac and lung complications compared with saline.Intravenous magnesium sulfate to improve outcome after aneurysmal subarachnoid hemorrhage: interim report from a pilot s…
- In adolescents with metabolic syndrome, 100 mg per day of grape seed extract for 8 weeks improved insulin resistance compared with placebo, while blood pressure changes were not statistically significant.Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndro…
- In 40 women with polycystic ovary syndrome, 250 mg of magnesium oxide daily for 2 months did not change blood pressure compared with placebo, although insulin resistance and some cholesterol measures improved.The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Synd…
- In 40 adults with acute asthma, inhaled magnesium sulfate was compared with inhaled salbutamol; blood pressure was recorded, but the abstract reports no blood pressure result, and salbutamol worked better for asthma.Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma.
- In 40 adults with high cholesterol, 100 mg of grape seed extract twice daily for 2 months did not change blood pressure compared with placebo.Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic su…
- In 39 adults with mild hypertension, GABA fermented milk for 12 weeks lowered systolic blood pressure by 17.4 mmHg, significantly more than placebo.Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives…
- In 39 adults with mild hypertension, 150 g of GABA-enriched rice daily for 8 weeks improved morning home blood pressure versus placebo rice, but hospital and evening blood pressure did not change significantly.Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure.
- In adults with pre-hypertension, 300 mg per day of grape seed extract in a juice for 6 weeks lowered systolic and diastolic blood pressure compared with placebo, and the effect faded after stopping.Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a r…
- In 30 people with pre or mild-to-moderate hypertension, 4 weeks of GABA-enriched low-sodium bread did not lower 24-hour blood pressure more than regular or low-sodium bread.Effect of Functional Bread Rich in Potassium, γ-Aminobutyric Acid and Angiotensin-Converting Enzyme Inhibitors on Blood …
- In a pilot trial of 28 newborns with severe lung blood vessel constriction, nebulized magnesium sulfate over 24 hours gave a larger fall in the oxygenation index and a slightly higher average blood pressure than intravenous magnesium.Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled…
- In 26 women with obesity, 200 mg daily GABA for 90 days with exercise training produced no difference in blood pressure compared with placebo plus exercise.Effects of combined gamma aminobutyric acid supplementation and exercise training on the body composition of women: A ra…
- In 25 newborns with persistent pulmonary hypertension, intravenous magnesium sulfate did not produce a different response rate than inhaled nitric oxide, though infants who switched to nitric oxide after magnesium failed did better.Inhaled nitric oxide and intravenous magnesium sulphate for the treatment of persistent pulmonary hypertension of the ne…
- In 24 adults with metabolic syndrome and normal magnesium levels, 400 mg of magnesium citrate daily for 12 weeks lowered systolic and diastolic blood pressure and HbA1c compared with placebo.Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome…
- In adults with mild dyslipidemia, a 3-week intake of 1500 mg of a Chardonnay seed extract blend lowered systolic blood pressure and improved postprandial triglycerides in some comparisons, but also lowered HDL cholesterol compared with the marc blend.Chardonnay grape marc/grape seed extract blends improve postprandial triglycerides and/or HDL cholesterol concentrations…
- In 22 hemodialysis patients, using a low-magnesium dialysis bath did not significantly change QT dispersion, a measure of heart rhythm risk, compared with a normal-magnesium bath.The effect of different dialysate magnesium concentrations on QTc dispersion in hemodialysis patients.
- In 20 dialysis patients, a higher magnesium dialysate concentration did not change intradialytic blood pressure or heart stunning compared with a lower concentration over 2-week periods.High magnesium dialysate does not improve intradialytic hemodynamics or abrogate myocardial stunning.
- A single dose of grape seed extract lowered systolic and mean arterial blood pressure within 2 hours compared with placebo in normal weight and obese men, through reduced cardiac output in the obese group.Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.
- In 14 people after a brain bleed, a 5 gram intravenous magnesium bolus slightly lowered average blood pressure compared with saline but did not change blood flow speed in the brain.Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.
- In 14 adults at risk of type 2 diabetes, a supplement with 300 mg grape seed extract plus bilberry daily for 12 weeks lowered 24-hour systolic and diastolic blood pressure compared with a control extract.A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECI…
- In sedentary adults with elevated blood pressure, grape seed extract did not change blood pressure recovery after exercise, but 7 days of use lowered resting mean arterial pressure while a later dose transiently raised it.Effects of acute and short-term grape seed extract supplementation on blood pressure responses to exercise in individual…
- In 7 healthy young adults, a single 10 g dose of GABA vegetable tablets did not change systolic or diastolic blood pressure compared with control tablets.Effects of vegetable containing gamma-aminobutyric acid on the cardiac autonomic nervous system in healthy young people.
- In children with critical hand, foot and mouth disease, magnesium sulfate added to routine treatment lowered systolic blood pressure and heart rate more than routine treatment alone.The clinical value of aquaporin-4 in children with hand, foot, and mouth disease and the effect of magnesium sulfate on …
- In adults with metabolic syndrome, 300 mg per day of grape seed extract for 4 weeks lowered both systolic and diastolic blood pressure compared with placebo, measured by ambulatory monitoring.Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome.
- In healthy adults, 300 mg per day of a grape seed extract for 16 weeks lowered blood pressure more than placebo, though the effect was not seen in men.Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Control…
- In 119 people with normal-to-mildly high blood pressure, grape seed extract (150 or 300 mg daily) for four months improved blood pressure more than control, and blood pressure normalized in 93% of the 300 mg group.Grape seed procyanidins in pre- and mild hypertension: a registry study.
- In 69 pregnant women with high blood pressure, pretreatment with magnesium sulphate before tracheal intubation prevented the rise in blood pressure seen with lignocaine, and only 1 of 24 magnesium-treated women had a systolic pressure above 180 mm Hg afterward, compared with 6 of 24 given alfentanil and 6 of 21 given lignocaine.Attenuation of the pressor response to tracheal intubation in hypertensive proteinuric pregnant patients by lignocaine, …
- In an open, non-randomized study of 62 pregnant women with high blood pressure, a combined regimen that included magnesium orotate along with meds delayed pregnancy complications compared with a control group, but the magnesium effect cannot be separated from the other treatments and blood pressure itself was not reported as a separate result.[Basic and metabolic therapy of hypertensive disease in pregnant women].
- In 10 men with elevated or stage 1 hypertension, one week of grape seed extract lowered resting diastolic blood pressure and mean arterial pressure compared with placebo, but did not change systolic blood pressure.Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevat…
- In nine young healthy people, magnesium infused into the arm improved blood vessel widening in response to methacholine, but overall blood pressure was not significantly changed.Magnesium infusion improves endothelium-dependent vasodilation in the human forearm.
- In 9 prehypertensive men, a single 300 mg dose of grape seed extract reduced mean arterial pressure during moderate and higher intensity cycling compared with placebo.Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men.
- In 7 people given intravenous GABA infusions, mood worsened in a dose-related way and pulse and blood pressure rose, while placebo infusions caused no such changes.Intravenous GABA administration is anxiogenic in man.
- In overweight and obese men, one week of grape seed extract lowered mean arterial pressure at rest and during exercise compared with placebo, alongside reduced aortic stiffness.Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/ove…
- In young males, 7 days of grape seed extract alone or with L-citrulline did not reduce resting or exercise blood pressure compared with placebo.Effect of Combined Grape Seed Extract and L-Citrulline Supplementation on Hemodynamic Responses to Exercise in Young Mal…
- In an observational study of 1,160 patients with heart rhythm disorders, at least 300 mg of oral magnesium per day for at least 6 weeks gave good to very good results in 82% of patients, and high blood pressure also improved.[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia]…
- In a 1986 survey of 976 coloured adults in Cape Town, hypertensive people had lower dietary magnesium intake than normotensive people, but this survey did not test magnesium supplements.Hypertension in the coloured population of the Cape Peninsula.
- In 100 women with severe preeclampsia, a 6 g intravenous dose of magnesium sulfate lowered maternal systolic blood pressure from about 173 to 157 and diastolic from about 110 to 102 within 20 minutes, and also lowered heart rate.The effect of loading dose of magnesium sulfate on uterine, umbilical, and fetal middle cerebral arteries Doppler in wom…
- In 10 hypertensive late-pregnancy women, a 4 g intravenous infusion of magnesium sulfate mildly lowered blood pressure and reduced peripheral resistance while increasing stroke volume and cardiac output.[The value of magnesium sulfate in intensive care of severe toxemias of pregnancy (author's transl)].
- In 8 women with severe gestational proteinuric hypertension, a magnesium sulphate infusion significantly lowered blood pressure, with the largest drop in diastolic pressure in those whose serum magnesium rose most.The effect of magnesium sulphate infusion on circulating catecholamine levels in severe gestational proteinuric hyperten…
- In 22 patients on long-term meds for high blood pressure or heart failure, 10 mmol of magnesium chloride per day for four months lowered systolic and diastolic pressure by about 13 mm Hg on average.Role of magnesium in the management of hypertension.
- In a nonrandomized study of 7 premature newborns with persistent pulmonary hypertension, intravenous magnesium sulfate led to clinical improvement in 6 infants, with no significant side effects, though blood pressure results were not separately reported.Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.
- In rats with chronic hypertension, Taurisolo grape extract lowered systolic blood pressure, and in healthy volunteers 400 mg twice daily for 8 weeks improved blood vessel dilation.Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Fun…
Review Totals and Summary
Members Only51 reviews · 93% positive
51 reviews · Ug.iherb 51
93% positive0% neutral7% negative
Across the stores that sell it, Dr. Sinatra Advanced BP Support carries about 51 ratings, and the star ratings lean positive, with three in four of the starred reviews giving 4 or 5. A good share of buyers say their readings improved, while a smaller group saw no change. **What buyers say it did for them:** Many describe lower or steadier numbers on their home monitor or at the doctor's office. One wrote "within a week, my BP dropped to 130." Another said "saw bp lower in 3 weeks." Some report long-term steadiness, such as "the most consistently good BP readings over a long span." A few say they were able to cut back on meds or avoid starting them. Several credit it together with diet, exercise or Dr. Sinatra's food advice. **What they complain about:** The main complaint is no result. One buyer took it over two months with "absolutely no notable results" and planned to send back the unopened bottles. Others said it "hasn't helped my blood pressure at all" after a month or after two bottles. Some are unsure after a few weeks. One reviewer reported dizziness when taking it with an afternoon meal and moved the dose to dinner. Another reported skin reactions and photosensitivity for her husband, though his readings were mostly in range. **Taste, smell, pill size or form:** It comes as capsules, four per serving. Taste was barely mentioned. One buyer got a "kick back" taste at first, and it went away when taking it with a meal. **Value for money:** No one wrote about price. Some signs of satisfaction show in repeat buying: one reviewer reordered "to stock up and to share with my sister," and another plans to order more. **Who it seems to suit and who it did not:** Buyers with readings only a bit high, such as one at 135/90, reported good results. People with long-standing high readings were split. One called it "one of the few supplements that made a difference," while another said all supplements "did nothing to my high blood pressure." One reviewer said it may help people near the margins. Some use it next to their regular meds, and several say it takes a couple of weeks or more to show on a monitor. Buyers who already follow a healthy diet and exercise had mixed outcomes, with some improving and one seeing nothing.
Biohacker Summary
Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it
Magnesium is only a smaller ingredient in this product, yet all ten panelists spoke about it, and most of them recommend or use it. Sleep is the top reason, with several taking or suggesting it at night, and others point to muscle cramps, blood pressure, bone health, and vitamin D function. Threonate and glycinate are the forms the panel prefers, and four of them take 400 mg of threonate before bed, while others mention daily totals of 300 to 500 mg or more. Some pair it with electrolytes such as sodium and potassium, or with vitamin D, B1, and protein, and one panelist said it does not fix waking up during the night, while another stayed neutral after reviewing the evidence on it for sleep.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends hawthorne berry extract as a natural remedy for angina, irregular heartbeat, and various circulatory and respiratory problems, suggesting it's good to keep around, especially when traveling.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Includes hawthorn berries in his smoothie.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 4 for Blood Pressure
Grape seed extract at a full dose has modest support for lowering blood pressure, and star ratings are mostly positive. However, only 57% of buyers who mention blood pressure say it helped, so the reviews disagree with the ratings and the product stays at tier 4.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 29 of the 85 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Nervous system
Combine with: Heart and blood pressure formulas are often paired with potassium, since it works on the same fluid and sodium balance pathway as magnesium. Magnesium is often paired with vitamin B6, which helps cells take it up. Coenzyme Q10 is often paired with this group because it supports energy production in heart muscle, and omega-3 fatty acids are often paired with it because they act on blood vessel function through a separate route.
Possible side effects: One buyer reported dizziness when taking it with an afternoon meal, and another reported skin reactions and sun sensitivity in her husband. One buyer noticed an aftertaste that went away when taking it with a meal.
Supplement Facts
Magnesium 250 mg · Chinese Hawthorn Leaf Extract 600 mg · MegaNatural-BP 150 mg
Supplement Facts
Serving Size 4 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Magnesium | 250 mg | |
| Chinese Hawthorn Leaf Extract | 600 mg | † |
| MegaNatural-BP | 150 mg | † |
| PharmaGABA | 50 mg | † |
† Daily Value not established.
Other ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Magnesium Stearate, Silica.
Directions: Doctor's Suggested Use: Take 4 capsules once daily with a meal.
Barcode (UPC) 678829201351 · Label source: NIH label database · Report a label change
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Graded November 15, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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