Lake Avenue Nutrition Methyl Folate 800 mcg Review

Methyl Folate 800 mcg by Lake Avenue Nutrition is listed on HelloPharmacist as a supplement in capsule form, with two active ingredients in each serving of 1 capsule. The label, dated November 22, 2024 and filed with the NIH Dietary Supplement Label Database, lists Vitamin C 40 mg (44% Daily Value), Folate 1360 mcg DFE (340% Daily Value), and (6S)-5-Methyltetrahydrofolic Acid Calcium Salt 800 mcg. The label describes the folate as bioavailable 5-MTHF. The container holds 120 servings. Other ingredients are rice flour, modified cellulose and magnesium stearate. The suggested use on the label is to take 1 capsule daily with food, or as recommended by a qualified healthcare professional. The label says to store the product in a cool, dry place and to protect it from heat, light and moisture. The FDA statement says it has not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The brand is a registered trademark of Madre Labs, LLC, based in Irvine, California. The label states the product is formulated without gluten, GMOs or soy, and the page's allergen check finds no major food allergen named in the ingredient names. The page rates ingredient transparency as full because each active ingredient has an exact amount listed. The page compares the vitamin C amount with other products in its database and says it is less than most of them, while noting that this comparison is not a recommended dose. The page reports documented drug interactions for the vitamin C content, with 207 drugs listed and every one rated moderate. Examples include meds such as a med, hormone medicines, certain chemotherapy drugs, aluminum-containing antacids, the antipsychotic fluphenazine and the HIV drug indinavir. The folate ingredient has no interaction records on file. Side effects reported with vitamin C include upset stomach, nausea, stomach cramps, diarrhea, heartburn and headache. Kidney stones are described as a rare but more serious concern with very high or long-term high doses. The page advises people with kidney disease, a history of kidney stones, hemochromatosis or G6PD deficiency to talk with a doctor or pharmacist before starting. For pregnancy and breastfeeding, the page rates vitamin C as likely safe when used orally and appropriately, but possibly unsafe in excessive doses. It holds no such data for the folate ingredients. For the research on vitamin C, the page grades the evidence for its stated use as strong, with vitamin C deficiency rated effective. The page also notes that these grades describe each ingredient in general and not this exact product. Lake Avenue Nutrition has 118 products in the database, all on the market, with labels on file since 2022.

Product Focus: MoodAlso covers:Brain
Tier ⓘ
Tier 4 · Rank 5
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 5 within Tier 4 for Mood; 27 of 32 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
48 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
100% of 4
Biohacker Mentions
9 of 10

Study, Trial or Testing Result Summary

Members Only92 human studies · 44 improved

4 of these 92 human studies gave the ingredient by drip or inhaler, not by mouth.

92 human studies44 improved23 no effect164,721 people studied

This product gives folate as methylfolate at a full dose, above the amount that worked in studies and above the daily recommended limit, so members may choose to take less. Most evidence shows folate helps mood when added to a med medicine. A large pooled analysis of 192 trials found added folate eased depression more than medicine alone [1]. Another analysis of nine trials agreed and found side effects similar to placebo [2]. Pooled trials of the methylfolate form found a modest gain in symptoms and response [3]. A review of 20 trials found folate with other B vitamins and vitamin D lowered depression scores, alone or with medicine [4]. Not every study agreed. Adding high dose folic acid for 12 weeks did not help 475 adults on meds [5]. Seven years of folic acid with other B vitamins did not prevent depression in older women [6]. The vitamin C here is below the studied dose. At higher doses, vitamin C gave a small mood benefit in people with mild depression [7] and improved well-being in young adults with low vitamin C [8]. It also lowered anxiety in small trials [9][10]. Animal and cell studies are never counted.

See all 92 studies →Hide the studies

Review Totals and Summary

Members Only4 reviews · 100% positive
4 reviews · Amazon 3 · Ubuy.hn 1
100% positive0% neutral0% negative

Across the stores, Lake Avenue Nutrition Methyl Folate 800 mcg has 3 ratings in total (all on Amazon), and the themes below come from the written reviews that could be read on that page. Only one written review was readable, so this is a very small base and should be read that way. What buyers praise: The single written review comes from a verified purchaser who gave it 5 out of 5 stars under the title "Great Product." The text is brief and positive. The reviewer calls the product great and says they will buy it again, which signals satisfaction and an intention to repurchase. The review gives no detail on why they liked it, such as how it made them feel, how it compares with other folate supplements, or what they were using it for. What buyers complain about: No complaints appear in the written feedback. Nothing is said about taste, capsule size, dosing, or effectiveness, whether good or bad. The absence of complaints here reflects how little was written, not a confirmed record of problem-free experiences. Ratings pattern: The page shows only three global ratings. The star split is shown as 54% five-star and 46% four-star, with no three-, two-, or one-star ratings. Every rating is therefore positive, though with just three ratings the percentages move a lot with each individual score and do not say much about the wider buying public. The four-star ratings have no written explanation, so there is nothing to indicate what held those buyers back from a full five stars. Who it seems to suit: The review does not say who the product is for or what the reviewer's goals were. Nothing can be said about particular groups of users, dietary needs, or use cases from this feedback. Taste, form, and value: The review does not mention taste, the form of the capsules, how many are in a bottle, or price and value for money. No point can be drawn on these from what was readable. Other forms: The summaries did not include reviews of other forms of the product, such as gummies or powder, so nothing had to be set aside. This summary is about the capsules only. Overall, the available feedback is warm but thin in detail: a verified buyer who was happy enough to say they would purchase again, and a rating split that leans fully positive across three ratings. Because there is only one written review and no further reviews to compare it against, the themes above cannot show a consistent customer experience across many buyers. Anyone considering the product would need to look for additional reviews, or for information from the manufacturer, to learn about taste, capsule size, dosing, and effectiveness.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Folate is the main ingredient here, and the panel leans toward recommending it: six of the ten recommend it and four are neutral. Reasons given include lowering homocysteine, supporting mitochondria and brain health, and protecting pregnancy and IVF preparation, with one noting that birth control pills deplete folate. Two of them prefer methylfolate, the active form, over folic acid, and one suggests getting it through a prenatal vitamin. No one gave a folate dose, paired it with another supplement, or said they stopped it. Vitamin C is a smaller ingredient in this product, and the panel mostly recommends it for collagen and skin, though one said high doses might not always be beneficial.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Folate · neutral
    • 21 Oct 2026 · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 6 Oct 2026 · Vitamin C · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
    • 30 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
    • 14 Sep 2026 · Vitamin C · recommends · Facebook ↗
      Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
    • 9 Sep 2026 · Vitamin C · uses · YouTube ↗
      Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
    • 31 Aug 2026 · uses · YouTube ↗
      Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
    • 28 Jul 2026 · neutral · Facebook ↗
      Notes that a med depletes folate.
    • 27 Jul 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C for immune system support and modulation.
    • 22 Jul 2026 · recommends · YouTube ↗
      States that folate is a nutritional deficiency that impacts mental health.
  • Dr. Eric Berg · Folate · neutral
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 24 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 23 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
    • 17 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
    • 20 Sep 2026 · Vitamin C · recommends · Facebook ↗
      Recommends consuming foods high in vitamin C to block the effects of grains.
    • 16 Sep 2026 · Vitamin C · recommends · YouTube ↗
      Recommends ensuring that collagen supplements come with vitamin C.
    • 14 Sep 2026 · Vitamin C · neutral · X ↗
      Vitamin C works as an antioxidant that supports skin and artery health.
    • 13 Sep 2026 · Vitamin C · recommends · Facebook ↗
      Recommends pairing collagen with vitamin C to support absorption.
    • 3 Sep 2026 · neutral · Facebook ↗
      Dr. Berg mentions that fermented dairy contains vital nutrients, including folate.
    • 1 Sep 2026 · Vitamin C · neutral · X ↗
      Sauerkraut also contains vitamin C and beneficial bacteria that may support digestive health.
    • 3 Aug 2026 · recommends · Facebook ↗
      States that folate is a co-factor or nutrient involved in making melatonin.
    • 3 Jul 2026 · recommends · YouTube ↗
      States that if one is deficient in folate, cells cannot repair, and recommends dark leafy green vegetables, liver, and avocados as good sources.
  • Dave Asprey · Folate · neutral
    • 17 Oct 2026 · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 14 Aug 2026 · Vitamin C · neutral · Podcast ↗
      Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
    • 5 Aug 2026 · recommends · Facebook ↗
      Recommends methylfolate as a better option than folic acid.
    • 25 Jul 2026 · Vitamin C · neutral · Facebook ↗
      Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
    • 16 Jul 2026 · Vitamin C · warns · YouTube ↗
      Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
    • 14 Jul 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
    • 9 Jul 2026 · Vitamin C · warns · YouTube ↗
      Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
    • 14 Jun 2026 · Vitamin C · recommends · Podcast ↗
      Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
    • 11 Jun 2026 · recommends · YouTube ↗
      Dave Asprey notes that 80% of their clients have a problem absorbing certain forms of folate, and when the exact form of folate or folinic acid is dialed in, clients experience shifts, with the brain waking up as one of the first improvements.
    • 27 May 2026 · Vitamin C · warns · YouTube ↗
      States that Ensure is like SlimFast but worse, and that its ingredients, including synthetic vitamins, guar gum, maltodextrin, high fructose corn syrup, and seed oils, are disgusting and should not be given to sick or well people.
    • 19 May 2026 · Vitamin C · recommends · YouTube ↗
      Recommends IV Vitamin C, or even oral versions, for helping the body heal and for cells to remain supple and fluid.
    • 10 Apr 2026 · neutral · Podcast ↗
      Dave breaks down why a daily stack of taurine, B6, folate, and B12 works for motivation when either ingredient alone doesn't.
  • Ben Greenfield · Folate · recommends
    • 12 Oct 2026 · recommends · Facebook ↗
      Recommends methylfolate as an active form of folate that the body can use directly without conversion.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 24 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 25 Aug 2026 · Vitamin C · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
    • 9 Jul 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C for skin repair post-tattoo.
    • 18 Apr 2026 · recommends · YouTube ↗
      Recommends introducing methylfolate into the diet to address high homocysteine levels.
    • 7 Mar 2026 · Vitamin C · warns · YouTube ↗
      Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
    • 8 Jan 2026 · neutral · Facebook ↗
      Would refine the guidelines to include clearer distinctions between synthetic folic acid and natural folate.
    • 22 Nov 2025 · Vitamin C · warns · YouTube ↗
      Warns against ascorbic acid, stating that it does not cure scurvy and that the world has been led astray by the deception around it versus the whole food vitamin C complex.
    • 16 Nov 2025 · Vitamin C · warns · Facebook ↗
      Warns against taking 1,000 mg of vitamin C immediately after a workout for individuals under 50, as it can dull the body's natural adaptation signal.
    • 30 Oct 2025 · Vitamin C · warns · YouTube ↗
      Warns that using high-dose antioxidants like vitamin C directly before or after a hyperbaric session is not a great idea, as it could impair some of the effects by reducing reactive oxygen species.
    • 11 Oct 2025 · neutral · YouTube ↗
      Notes that some people do better on certain forms of B12, B complexes, SAM E, and methylated folates, specifically five methyl folates, for methylation.
  • Dr. Rhonda Patrick · Folate · recommends
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 5 Jun 2026 · Vitamin C · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
    • 4 May 2026 · Vitamin C · uses · YouTube ↗
      Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
    • 5 Feb 2026 · Vitamin C · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · Vitamin C · neutral · Facebook ↗
      Notes that ~35% of Americans are low in vitamin C.
    • 29 Dec 2025 · Vitamin C · recommends · X ↗
      Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
    • 9 Sep 2025 · Vitamin C · warns · YouTube ↗
      Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
    • 4 Sep 2025 · Vitamin C · neutral · Facebook ↗
      Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
    • 20 Aug 2025 · neutral · Instagram ↗
      Notes that dark leafy greens are a great source of folate.
    • 11 Aug 2025 · Vitamin C · uses · X ↗
      Currently takes the Pure Encapsulations O.N.E Multivitamin.
    • 26 Jun 2025 · Vitamin C · uses · Facebook ↗
      Rhonda's current supplement routine includes Vitamin C.
    • 27 Dec 2023 · recommends · YouTube ↗
      States that for his mother, who is homozygous for MTHFR, methyl folate along with a high dose B supplement is necessary to prevent her homocysteine and blood pressure from going high.
    • 30 May 2016 · neutral · YouTube ↗
      Dr. Patrick mentions that her smoothie is rich in folate, which is required for producing thymine and prevents DNA strand breaks.
  • Thomas DeLauer · Folate · recommends
    • 29 Jun 2026 · recommends · YouTube ↗
      Recommends taking methylfolate as a methylated form of B vitamin for mitochondrial function.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 4 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · Vitamin C · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 18 Sep 2026 · Vitamin C · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
    • 29 Aug 2026 · Vitamin C · neutral · Instagram ↗
      States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
    • 25 Aug 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
    • 19 Aug 2026 · Vitamin C · recommends · YouTube ↗
      Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
    • 8 Aug 2026 · Vitamin C · neutral · YouTube ↗
      Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
    • 29 Jul 2026 · Vitamin C · recommends · YouTube ↗
      Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends methylfolate as a runner-up for insulin resistance, especially for individuals with the MTHFR variant, as it directly enters the methylation cycle without conversion.
    • 25 Feb 2026 · neutral · YouTube ↗
      Mentions folate as a critical B vitamin for reducing homocysteine.
    • 15 Mar 2025 · neutral · YouTube ↗
      Lists folate as a metal donor found in green leafy vegetables, liver, and legumes, especially sprouted legumes.
  • Siim Land · Folate · neutral
    • 17 Jan 2026 · neutral · Instagram ↗
      States that Homocysteine levels can often be improved through adequate folate intake.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 6 Sep 2026 · Vitamin C · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 27 Jul 2026 · Vitamin C · neutral · X ↗
      Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
    • 27 Jul 2026 · Vitamin C · neutral · X ↗
      States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
    • 27 Jul 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
    • 9 Jul 2026 · Vitamin C · neutral · YouTube ↗
      Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
    • 4 Jul 2026 · Vitamin C · uses · YouTube ↗
      Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
    • 12 Jun 2026 · Vitamin C · recommends · YouTube ↗
      States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
    • 23 Aug 2025 · warns · YouTube ↗
      Notes that Brian's folate levels are over 20, which is too high and above the reference range, possibly due to supplementation.
    • 15 Feb 2025 · warns · YouTube ↗
      Warns that many people are overdosing on methyl folate, which can contribute to overstimulation when combined with creatine.
    • 4 Nov 2024 · neutral · YouTube ↗
      Notes that folate resulted in negative effects on epigenetic age, meaning it increased epigenetic age.
  • Andrew Huberman · Folate · recommends
    • 31 Mar 2025 · recommends · YouTube ↗
      States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
    • 17 Jun 2026 · Vitamin C · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 2 Feb 2026 · Vitamin C · recommends · YouTube ↗
      Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
    • 7 Jul 2025 · Vitamin C · uses · YouTube ↗
      Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
    • 16 Jun 2025 · Vitamin C · uses · YouTube ↗
      Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
    • 28 Apr 2025 · Vitamin C · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
    • 3 Feb 2025 · Vitamin C · uses · YouTube ↗
      Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
    • 18 Nov 2024 · Vitamin C · uses · YouTube ↗
      Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
    • 14 Oct 2024 · Vitamin C · recommends · YouTube ↗
      Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
    • 7 Oct 2024 · recommends · YouTube ↗
      Recommends taking methyl folate as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
    • 12 Aug 2024 · Vitamin C · uses · YouTube ↗
      States that AG1 is the highest quality and most complete foundational nutritional supplement available, containing vitamins, minerals, probiotics, prebiotics, and adaptogens, and that he has been taking it daily since 2012, often twice a day, to bolster his energy, immune system, and gut microbiome.
    • 2 Aug 2024 · Vitamin C · recommends · YouTube ↗
      Huberman mentions that vitamin C seems to help with the absorption or utilization of collagen protein.
    • 29 Jul 2024 · uses · YouTube ↗
      Takes methyl folate because elevated levels of homocysteine are associated with negative outcomes, and taking methyl folate is known to lower homocysteine. This might lower ADMA and SDMA and raise nitric oxide synthesis, potentially impacting vascular disease.
    • 22 Aug 2022 · neutral · Podcast ↗
      Discusses folate as a potential factor in mitigating cancer risk, particularly in relation to alcohol consumption.
  • Peter Attia · Folate · recommends
    • 19 Aug 2024 · recommends · YouTube ↗
      Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
    • 3 Jul 2025 · Vitamin C · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · Vitamin C · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 6 Sep 2024 · Vitamin C · neutral · YouTube ↗
      States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
    • 19 Aug 2024 · Vitamin C · recommends · YouTube ↗
      Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
    • 24 Oct 2023 · uses · YouTube ↗
      Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
    • 23 Oct 2023 · uses · YouTube ↗
      Takes Jarrow methylfolate, a methylated version, once a day at the lower of two strengths, to keep homocysteine levels below nine.
    • 28 Aug 2023 · neutral · YouTube ↗
      Mentions that in a mouse model for obesity, the amount of folate given to the mother mouse during pregnancy affects the epigenetics of her offspring, leading to changes in coat color and obesity.
    • 5 Jun 2023 · uses · YouTube ↗
      Personally takes methylfolate to help get homocysteine into the desired zone and prefers the Jarrow brand.
    • 7 Mar 2022 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
    • 24 Jan 2022 · Vitamin C · neutral · YouTube ↗
      Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
    • 19 Oct 2020 · Vitamin C · warns · YouTube ↗
      Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
    • 10 Aug 2020 · Vitamin C · recommends · YouTube ↗
      Asks if vitamin C matters for immune function, suggesting a need for a definitive study.
    • 12 Mar 2020 · Vitamin C · warns · YouTube ↗
      Warns against the "total nonsense" of taking excessive amounts of vitamin C, especially in specific forms like liposomal vitamin C, for immunity, stating that it is idiotic and potentially dangerous to think it will offer immunity.
  • Bryan Johnson · Folate · recommends
    • Date not recorded · recommends · Source ↗
      Recommends supplementing with folate for brain health for both the mother and the baby during pregnancy.
    • 3 Feb 2025 · Vitamin C · neutral · YouTube ↗
      Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
    • 8 Jan 2025 · Vitamin C · uses · YouTube ↗
      Applies vitamin C after showering.
    • 26 Sep 2023 · Vitamin C · uses · YouTube ↗
      Takes 250 milligrams of Vitamin C.
    • Date not recorded · Vitamin C · recommends · Website ↗
      Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
    • Date not recorded · Vitamin C · uses · Website ↗
      Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
    • Date not recorded · Vitamin C · uses · Website ↗
      He uses Vitamin C, typically in a serum, in the morning for skin health.

RAL Summary

Members OnlyTier 4 for Mood

Human studies, especially of folate added to meds, support a mood benefit, but there are only 4 reviews, too few to confirm it, so the product stays at the emerging tier.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 23 of the 92 human studies found no effect.

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Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system

Combine with: For mood and methylation support, pair it with methylcobalamin (B12) and pyridoxal-5-phosphate (B6) to help lower homocysteine, plus magnesium, omega-3 fish oil (EPA/DHA), and vitamin D3. If vision is still the goal, add a dedicated eye formula with lutein (10 mg), zeaxanthin (2 mg), zinc with copper, vitamin C, vitamin E, and DHA-rich omega-3s, and consider astaxanthin or bilberry for added antioxidant support. Consult a healthcare provider, especially with anticonvulsants or a med, or if you have an MTHFR variant.

Possible side effects: In pooled folate trials, side effects and dropouts were similar to placebo. No side effects were mentioned in the reviews.

Supplement Facts

Vitamin C 40 mg · Folate 1360 mcg DFE
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 120
Amount Per Serving% Daily Value
Vitamin C40 mg
Folate1,360 mcg DFE

Other ingredients: Rice Flour, Modified Cellulose, Magnesium Stearate.

Directions: Suggested use: Take 1 capsule daily with food, or as recommended by a qualified healthcare professional.

Barcode (UPC) 898220016778 · Label source: NIH label database · Report a label change

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Graded November 8, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.