Leading Edge Health Profollica Plus with Millet Extract Review
Product Focus: Regularity: Long-Term ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 10
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 10 within Tier 4 for Regularity: Long-Term Relief; 12 of 16 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
19 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
75% of 1
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only1 human studies · 1 improved
This study gave pantothenic acid by drip, not by mouth.
1 human studies1 improved60 people studied
This product is sold as a hair formula, and there is very little research on it for bowel regularity. Its main studied ingredient is pantothenic acid, also called vitamin B5, at 30 milligrams a day. Only one human study has looked at a related form for bowel function. In a small, preliminary trial of 60 people recovering from bone and joint surgery, dexpanthenol, a form of pantothenic acid, was given through a vein on the second and third days after surgery. Higher doses shortened the time to the first bowel movement compared with salt water [1]. That study did not test pantothenic acid taken by mouth, and it did not test long-term relief of everyday occasional constipation. It looked only at bowels slowing down right after surgery [1]. It is not known whether 30 milligrams by mouth would have any similar effect. The other ingredients, biotin, millet extract, maidenhair fern and L-cysteine, have no human studies for regularity. Millet extract, maidenhair fern and L-cysteine are also present only in very small amounts. Larger studies of oral supplements in people with ongoing constipation are needed before anyone can say whether this product helps. Animal and cell studies are never counted.
See all 1 studies →Hide the studies
- In 60 orthopedic surgery patients given intravenous dexpanthenol (a pantothenic acid derivative) on the second and third days after surgery, the time to first bowel movement got shorter as the dose went up compared with saline, though the study was small and preliminary.A pilot study of the effect of pantothenic acid in the treatment of post-operative ileus: results from an orthopedic sur…
Review Totals and Summary
Members Only1 reviews · 75% positive
1 reviews · Google Shopping 1
75% positive0% neutral25% negative
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Only three of the ten panelists spoke about pantothenic acid, the main ingredient, and none gave a dose. Two of them recommend it: one for fatigue because it helps fat-burning enzymes, and one for adrenal support, taken on its own or from a B complex, while a third mentioned it as part of a program to repair mucosal membranes. The third panelist praised it for fat metabolism and weight loss but warned that high doses can cause dry skin. Cysteine is a smaller ingredient in this product, and most of the panel takes or recommends it as N-acetylcysteine to support glutathione, though a few warn about sulfur sensitivity or pregnancy, and one stopped taking it daily. Biotin is also a smaller ingredient, and several panelists warn that it can skew blood test results, so it should be stopped for a few days before testing.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Pantothenic Acid · recommends
- Mentions pantothenic acids as one of the things that can be used to repair mucosal membranes as part of the 'repair' step in the 4R program.
- States he was giving all his patients N-acetylcysteine for COVID-19, which he later learned blocked von Willebrand factor, preventing micro clots.
- Uses N-acetylcysteine to break open bacterial biofilms, allowing antimicrobials to be more effective.
- Uses N-acetylcysteine to help glutathione, detoxification, and as an antioxidant.
- Recommends N-acetylcysteine for male fertility, noting it acts as an antioxidant and boosts glutathione, a powerful antioxidant.
- Lists N-acetylcysteine as a powerful mitochondrial nutrient.
- Lists N-acetylcysteine as an antioxidant that helps mitochondrial function and boosts glutathione.
- Expresses confusion as to why N-acetylcysteine, also known as NAC, was considered for regulation by the FDA, given its role in boosting glutathione and its use in emergency rooms for overdose treatment.
- Includes N-acetylcysteine in a mitochondrial cocktail for heart failure patients, noting that it helps improve cardiac function.
- Mentions N-acetylcysteine as a compound that boosts glutathione, which is important for upregulating the body's detox system.
- Mentions using N-acetylcysteine, among other things, to lower lipoprotein little a, though it's not an easy treatment.
- Recommends supplementing with biotin for hair follicle health and growth.
- Includes biotin as part of the IV drip protocol for detoxification.
- States that millet is a little high glycemic but can be had.
Ben Greenfield · Pantothenic Acid · recommends
- Recommends Vitamin B5 (pantothenic acid) as a critical nutrient for adrenal gland support, suggesting it can be obtained from a B complex or Vitamin B5 itself.
- A new study found that lowering cysteine in the diet of mice significantly increased calorie burning and weight loss, matching the metabolic effects of cold exposure.
- N-acetylcysteine was mentioned in a study as a biofilm disruptor that can improve microbial access and affect outcomes in SIBO and methane-dominant cases.
- Notes that 10X Health System's methylene blue tablets plus light stack supports energy and recovery at the cellular level by powering antioxidant pathways with N-acetylcysteine (NAC).
- Recommends N-acetylcysteine (NAC) as a supplement that supports the body's own glutathione production and has been studied for air pollution.
- Recommends biotin (Vitamin B7) for supporting keratin production and strengthening hair, noting it can be found in eggs, almonds, and salmon.
- Ben Greenfield recommends the combination of N-acetylcysteine and glycine for its antioxidant and anti-inflammatory effects, which are beneficial for healing the lungs and for age reversal.
- Warns that biotin could mess with a blood test and make certain lab tests unreliable if used leading up to the test.
- Ben says that cysteine is very scarce in our diet, and if you have cysteine-rich foods like whey proteins, avocados, and sulfur-containing products, your body can absorb the cysteine and make glutathione out of it.
- Mentions N-acetylcysteine as something that can help accelerate the liver's detox pathways to get rid of acetaldehyde more quickly.
- Takes n-acetylcysteine to mitigate any acetaldehyde left over from alcohol.
- Warns of biotin deficiency on a carnivore diet, as it is low in meat but found in organ meats like liver, heart, kidney, and thymus glands.
- Ben Greenfield recommends looking into N-acetylcysteine, which acts very similar to glutathione, to support the body's liver detoxification pathways.
- Ben recommends N-acetyl cysteine (NAC) at 600 to 1,200 milligrams daily, stating it's a potent antioxidant that optimizes glutathione production and can help reduce oxidative stress and damage from meds or kratom.
Thomas DeLauer · Pantothenic Acid · warns
- Explains that Vitamin B5, or pantothenic acid, is tremendous for fat metabolism and weight loss, but warns that taking it in high doses can cause skin dryness.
- Recommends taking N-acetylcysteine to cover both glycine and cysteine for glutathione production, hitting detoxification from two directions.
- Recommends N-acetylcysteine (NAC) as a precursor to glutathione, noting that a study showed it increased glutathione and reduced fasting glucose, insulin resistance, and inflammation.
- Recommends taking N-acetylcysteine (NAC) alongside creatine and glycine, as it stacks well and supports glutathione production.
- Takes N-acetylcysteine (NAC) because it significantly helped his chronic sinusitis by loosening mucus. He also notes its involvement in glutathione production and mentions studies on its effect on hair pulling due to stress.
- Thinks biotin is a little overhyped, suggesting that consuming adequate protein is probably more effective for hair, skin, and nails. He notes that some people might be deficient, especially if consuming a lot of eggs with avidin, but doesn't consider it the 'Mecca of perfect hair'.
- Recommends N-acetylcysteine (NAC) for whole-body detoxification, explaining it's the rate-limiting precursor for glutathione, a master antioxidant, and directly scavenges oxidative stress, reduces fatigue, and is used in emergency rooms for a med overdose.
- Recommends N-acetylcysteine for hair graying, stating it is a precursor to glutathione and can help with oxidative stress directly linked with the follicle and stem cells.
- Uses 300 to 600 mg of N-acetylcysteine when his cortisol or inflammatory state is high to help with glutathione production and build antioxidant defenses.
- Recommends N-acetylcysteine (NAC) at 400 to 600 mg per day for 3 weeks on, 1 week off, as a precursor to glutathione, a crucial antioxidant for hair follicles.
- Recommends N-acetylcysteine (NAC) as a good precursor to glutathione, suggesting 600 milligrams to support natural levels.
- Recommends N-acetylcysteine (NAC) as a direct precursor to replenish glutathione levels, suggesting a dose of 300-600 mg in a cycle, particularly when stressed.
- Recommends ensuring sufficient biotin intake, either through diet or supplementation, if hair and nail health is the focus, as it acts as a co-factor for collagen to organize into robust matrixes.
- Takes biotin because her hair had stopped growing for a year, and it has helped her hair grow again.
Dr. Eric Berg · Pantothenic Acid · recommends
- Dr. Berg recommends taking B5 (pantothenic acid) if experiencing fatigue, as it acts as a helper for fat-burning enzymes.
- States that thinning hair often indicates low biotin, which is required to produce keratin for hair, skin, and nails.
- Notes that fungus on nails, identifiable by yellowish discoloration, is an indication of low biotin due to an imbalance in the gut.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including biotin.
- Dr. Eric Berg recommends biotin as a home remedy to help prevent hair loss and regrow hair.
- Mentions that fermented dairy provides vital nutrients such as biotin.
- Recommends N-acetylcysteine (NAC) to significantly reduce glutamate spikes, suggesting a dose of 600-2400 mg per day depending on the severity of the problem.
- States that cysteine is needed to make glutathione, which is essential for detoxification.
- Emphasizes that biotin is a vital cofactor for collagen absorption and function.
- States that brittle nails are usually caused by a biotin deficiency.
- Recommends getting biotin from a food source rather than a supplement for hair growth.
- Recommends biotin for hair growth, stating it is necessary to make keratin, which improves the hair shaft, makes it strong, and prevents thinning, fragility, and breakage.
- Identifies cysteine as one of the two amino acids from which the majority of dietary sulfur is obtained.
- Suggests increasing biotin with a supplement if one has a biotin deficiency.
Dave Asprey · Biotin · warns
- Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
- Dave Asprey warns that taking too much N-acetylcysteine (NAC) can cause problems for individuals with sulfur metabolism issues, leading to inflammation and negative tissue remodeling.
- Recommends pairing vitamin C with N-acetylcysteine (NAC) to increase glutathione, a master antioxidant in the brain that recycles vitamin C.
- States that biotin clears out oxalates.
- States that if he had to pick three raw materials that matter most for aging, cysteine would be one of them, as it helps make glutathione.
- Lists biotin as an important nutrient for hair health.
- Warns against taking biotin for a substantial period of time before lab testing, especially expensive immune stuff, because it will make results insane and doctors will think you're dying.
- Takes more biotin than others' genetics probably need.
- Takes excessive amounts of biotin due to his genetics, but warns that others may not need the same amount.
- Takes a substantial amount of biotin, believing it helps with oxalate removal, and noticed oxalate detoxing issues like deep pimples when increasing his dose.
- Warns that more people will be harmed by 20 milligrams of biotin a day than will be helped, and he himself developed significant neurological problems from taking 10 milligrams of biotin a day for five weeks.
- Warns that people sometimes overdo cysteine and other sulfur amino acids, which can lead to a pro-inflammatory sulfur profile.
- Believes N-acetylcysteine is very powerful and worth taking.
- He takes N-Acetylcysteine when he flies to protect his detox systems and help his body be more resilient.
Siim Land · Cysteine · neutral
- Mentions that cysteine is one of the main precursors needed for glutathione.
- Notes that cysteine can decrease homocysteine.
- Siim Land's company has published papers and filed patents for improvement in mitochondria in the skin using their core mitochondrial approach and other things like biotin.
- States that N-acetylcysteine is very important as a glutathione precursor to help support biotransformation, detox, and elimination.
- Used to experiment with N-Acetyl Cysteine (NAC) but now pulses it, being careful with sulfur-based supplements.
- Found that N-acetylcysteine and Boron brought his LDH levels down from over 200 to around 150, which is related to oxidative stress and recovery.
- Mentions that N-acetyl cysteine is a nutrient that can help with quicker recovery.
- Discusses evidence suggesting that for general longevity, a balance is desired between sulfur amino acids like cysteine, which are abundant in animal proteins, and glycine.
- Recommends NAC (N-Acetyl Cysteine) as a precursor of glutathione that raises antioxidant levels, guarding against oxidative stress and inflammation to combat accelerated aging and disease.
- Recommends N-acetylcysteine, particularly in conjunction with glycine, to boost glutathione levels, reduce oxidative stress, lower inflammation, and positively affect the immune system, contributing to overall protection against aging.
- Discusses a study where N-acetyl-cysteine supplementation, combined with glycine, extended the lifespan of mice and improved various health markers in both mice and humans.
- Mentions biotin as a nutraceutical with anti-thrombotic potential, increasing cyclic GMP.
- Recommends Biotin (Vitamin B7) for maintaining youthful skin, hair, and nails.
Andrew Huberman · Biotin · neutral
- Mentions biotin.
- Mentions N-acetylcysteine for endometriosis or chronic inflammatory disease.
- Supplements with N-Acetyl Cysteine to support glutathione production and detoxification.
- Supplemented with N-acetylcysteine to support glutathione production and detoxification, which helped reduce his mercury levels.
- Reduced his mercury levels by supplementing with N-Acetyl Cysteine (NAC), which can support glutathione production and detoxification.
- Supplements with NAC (N-acetylcysteine) to support glutathione production and detoxification, which helped reduce his mercury levels.
- Supplements with N-acetylcysteine (NAC) to support glutathione production and detoxification, which helped reduce his mercury levels.
- Was advised to supplement with NAC (N-acetylcysteine) to support glutathione production and detoxification, which helped reduce his mercury levels.
- Supplements with N-Acetyl Cysteine to support glutathione production and detoxification.
- Mentions N-Acetylcysteine (NAC) as a tool for detoxification.
- Supplements with NAC (N-acetyl cysteine) to support glutathione production and detoxification, which helped reduce his mercury levels.
- Discusses biotin-enriched shampoos as a potential way to offset dryness and brittleness from ketoconazole, noting that while sufficient biotin is important, it's unclear if these shampoos significantly enhance biotin incorporation into hair.
Dr. Rhonda Patrick · Biotin · warns
- Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
- Is taking N-Acetylcysteine (NAC) because it is a great antioxidant, packed with antioxidants, and recycles the glutathione peroxidase system, which is helpful in dealing with oxidative stress.
- Agrees with Rhonda that studies have shown N-acetylcysteine (NAC) can allow tumors to grow faster, citing research on metastatic melanoma and lung cancer.
- She occasionally uses biotin for hair and nails, meaning about twice a week.
- Plans to dive into N-acetylcysteine supplements next month, having done a literature search a few years ago and wanting to update on new literature.
- Notes that boosting glutathione levels through precursors like N-acetylcysteine (NAC) could help mitigate the effects of alcohol consumption, potentially easing hangover symptoms, though a placebo-controlled study found mixed results, with some potential benefits for women.
- Stopped taking N-acetylcysteine because two animal studies showed it caused lung tumors in healthy animals at high doses, which concerned her despite taking lower doses.
- Cysteine, along with other amino acids, regulates IGF-1 levels.
Peter Attia · Biotin · warns
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
- States that cysteine goes to part of creatinine or glutathione.
- Finds it silly to suggest that one needs to supplement biotin levels.
- Warns that biotin alone will not substantially improve female or male pattern hair loss, but it can make existing hairs stronger and needs to be coupled with other effective treatments.
Bryan Johnson · Cysteine · recommends
- Suggests that N-acetylcysteine could be helpful for managing reactive oxygen species if exposed to high air pollution.
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- Advises avoiding N-Acetyl-Cysteine during pregnancy.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
RAL Summary
Members OnlyTier 4 for Regularity: Long-Term Relief
Emerging tier: the only human evidence is one small, preliminary trial of a related form of pantothenic acid given through a vein after surgery, which shortened the time to the first bowel movement [1]. There is only one customer review, so there is not enough to rank it higher.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Pantothenic Acid 30 mg · Biotin 200 mcg · Millet Extract 420 mcg
Supplement Facts
Serving Size 2 Veggie Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Pantothenic Acid | 30 mg | |
| Biotin | 200 mcg | |
| Millet Extract | 420 mcg | † |
| Maidenhair Fern | 100 mcg | † |
| L-Cysteine | 6 mcg | † |
† Daily Value not established.
Other ingredients: Maltodextrin, Vegetable Cellulose, Vanillin, Medium Chain Triglycerides, Silicon Dioxide, Vegetable Stearate, Titanium Dioxide.
Directions: Suggested Use: 2 capsules daily preferably with meals or as directed by a healthcare professional.
Barcode (UPC) 628043006256 · Label source: NIH label database · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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