MYOGENIX Hyper Shock Rage Electric Orange Review
MYOGENIX Hyper Shock Rage Electric Orange is sold as a powder in a container holding 40 servings, with a net content of 880 grams. The page lists the brand as MYOGENIX, the form as powder, and the UPC as 680269382477, with DSLD ID 47891. The product is presented as an extreme pre-workout product that contains caffeine and is designed to be mixed with water and taken before exercise. Before first use, the page instructs buyers to open the container, remove the scooper, close the container securely, turn it upside down and shake vigorously for approximately five seconds, or until the contents are 100 percent free flowing. The product is then ready for use. The directions state that, as a dietary supplement, users should mix 1 to 3 scoops with 6 to 18 ounces of water and drink it 10 minutes before exercising, on an empty stomach. To assess tolerance, the page advises starting with one half of the recommended serving size for the first few workouts. The page recommends stacking the product with AMINO2 during workouts and AFTERSHOCK immediately after workouts for best results. A dosing chart is provided by body weight. For men, up to 155 pounds is 1 to 1 1/2 scoops, 155 to 225 pounds is 1 1/2 to 2 scoops, 225 to 275 pounds is 2 to 2 1/2 scoops, and 275 pounds and above is 3 scoops maximum. For women, up to 115 pounds is 1/2 to 1 scoop, 115 to 155 pounds is 1 to 1 1/2 scoops, and 155 pounds and above is 1 1/2 to 2 scoops maximum. The supplement facts list 50 calories and 12 grams of carbohydrate, with 0 grams of protein per serving, along with vitamin C at 500 mg, vitamin B6 at 30 mg, folate at 500 mcg, vitamin B12 at 225 mcg, calcium at 80 mg, magnesium at 175 mg, sodium at 25 mg, and potassium at 25 mg. The proprietary HYPERSHOCK blend provides 20 grams. Daily Values are not established for these ingredients. The warnings state that the product contains caffeine, should not be used with other stimulants or caffeinated products, and should not be used within 6 hours of bedtime. Consumers are told to follow the dosing chart carefully and not exceed the recommended serving size. The label notes that the product is manufactured in a facility that processes milk, soy, eggs and wheat. Before use, the warning advises consulting a doctor, especially for people with hypotension, hypertension, heart, liver or thyroid disease, diabetes, psychiatric disease, asthma, anxiety, depression, seizure disorder, cardiac arrhythmias, stroke, or those taking an MAO inhibitor or other meds. The product should not be used during pregnancy, when contemplating pregnancy, or while nursing. Users should discontinue if excessive sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitations occur. The page states it is for healthy adults only, not for persons under 18, and should be kept out of the reach of children. The page also links to the FDA Dietary Supplement Label Database record and a drug interaction check.
Tier ⓘ
Tier 3 · Rank 20
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 20 within Tier 3 for Energy; 45 of 91 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
71 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 342
Biohacker Mentions
9 of 10
Cost per month
$25
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Study, Trial or Testing Result Summary
Members Only118 human studies · 41 improved
14 of these 118 human studies gave the ingredient by drip or injection, not by mouth.
118 human studies41 improved64 no effect145,008 people studied
No studies tested the 20 gram Hypershock proprietary blend, which makes up most of this product, and its doses are hidden. Magnesium is at a full dose. Oral magnesium at 80 mg daily for 4 weeks lowered fatigue in 30 adults with metabolic conditions [1], and magnesium improved energy scores in 64 women with polycystic ovary syndrome [2]. Other trials found no fatigue benefit [3][4]. Vitamin C is at a full dose but seems to help mainly people with low levels. 250 mg daily improved well-being and fatigue in young adults low in vitamin C [5]. A large trial in people not low found no gain in vitality [6]. Vitamin B6 reaches a studied dose only at two servings a day. One small trial in women with premenstrual symptoms found less tiredness [7], but larger trials of B vitamin blends found no benefit [8]. For folate and vitamin B12 it is unclear how the doses compare with those studied, and most trials found no fatigue benefit [9][10]. Calcium is far below the studied dose [11]. Potassium is a small amount with mixed results [12]. Animal and cell studies are never counted.
See all 118 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- In 16 studies of 616 people with multiple sclerosis and 655 healthy people, folate and B12 blood levels did not differ, suggesting they are not drivers of worse physical function; this was not a supplement trial.The Relationship of Cobalamin and/or Folate to the Patient-Centred Outcomes in Multiple Sclerosis: A Systematic Review a…
- In two placebo-controlled trials of 404 adults with Charcot-Marie-Tooth disease type 1A, ascorbic acid at two doses over 12 to 24 months had little meaningful effect on fatigue.Interventions for fatigue in peripheral neuropathy.
- A review of 26 trials in 3,273 people with chronic fatigue syndrome found most supplements did not help, but magnesium and NADH showed benefit, though the trials were small and at high risk of bias.Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review.
- Across nine studies of 720 people, three of four controlled trials found intravenous vitamin C lowered fatigue scores more than control, and four of five uncontrolled studies saw fatigue fall.Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review o…
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of 37 studies in cancer patients found intravenous vitamin C may ease fatigue and other symptoms, but the evidence is preliminary and mostly uncontrolled.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of supplements for football players said vitamin C may improve performance by lowering oxidative stress, but gave no numbers and called for more research.The efficacy of dietary supplements on health status and performance of football players: a systematic review.
- In a review of four diet trials in people with multiple sclerosis lasting 3 to 12 months, two diets supplying enough folate and magnesium reported improved fatigue, but firm conclusions were not possible.Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review.
- In 8112 healthy French adults, a daily antioxidant capsule containing 120 mg vitamin C for about 6 years did not change quality of life scores, including vitality, compared with placebo.Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, pla…
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 697 adults with mild high blood pressure, a low-sodium, high-potassium diet with placebo for 6 months was linked to more fatigue (34%) than the usual diet (18%) or a weight loss diet (15%).Effect of antihypertensives on sexual function and quality of life: the TAIM Study.
- In 311 people receiving a med agonist therapy, a daily fruit smoothie for 16 weeks did not change fatigue, fitness, or folate levels compared with standard treatment alone.Read the study on PubMed (40877839) →
- In 275 adults with early COVID-19 given a 10-day combination that included vitamin C, less fatigue at day 14 was seen only when famotidine was added, not with the vitamin C combination alone.Read the study on PubMed (41693032) →
- In 271 adults with Charcot-Marie-Tooth disease type 1A, 1.5 g of ascorbic acid daily for 2 years did not differ from placebo on neuropathy or on secondary outcomes including fatigue.Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement for 33 days improved vigour, stress and mental health ratings and made them feel less mentally tired than placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 202 hemodialysis patients, a multinutrient supplement containing vitamin C for 12 weeks did not reduce fatigue compared with placebo, though some heart rate variability measures improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 14 days improved vitality and motivation, but blood vitamin C did not explain these benefits.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit gave somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In 162 adults on a weight loss meal replacement program, folate levels improved in both groups, and energy and fatigue improved slightly more with daily calorie restriction alone than with added alternate day fasting; folate was not tested alone.Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effe…
- In 160 heart bypass surgery patients, vitamin C plus omega-3 fatty acids given from the day before surgery through the first 5 days after reduced post-operative fatigue more than placebo.The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass gra…
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 141 healthy office workers, a single 10 gram intravenous vitamin C dose lowered fatigue scores for up to one day compared with saline placebo, especially in those with low starting vitamin C, and also lowered oxidative stress.Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
- In 112 women with anemia after childbirth, adding 1 mg a day of folic acid to iron for 4 weeks did not change fatigue scores, hemoglobin or health status compared with iron alone.A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartu…
- In 110 people with fibromyalgia, 3 months of a supplement with coenzyme Q10, tryptophan and magnesium did not significantly reduce fatigue (placebo improved significantly), though pain, sleep and overall impact improved.Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomiz…
- In a 3-month double-blind trial of 99 people with severe kidney failure taking 250 mg vitamin C three times weekly, symptoms including fatigue were similar to placebo, and nausea trended worse with vitamin C.Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
- In 98 adults with inflammatory bowel disease in remission, 4 weeks of magnesium plus B vitamins reduced fatigue more than placebo, and also lowered ulcerative colitis symptom scores but not Crohn's disease scores.Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 86 people with mental fatigue, a single dose of homeopathic potassium phosphate taken before an attention test did not work better than placebo, though the test's ceiling effect limits the result.Homeopathy for mental fatigue: lessons from a randomized, triple blind, placebo-controlled cross-over clinical trial.
- In 80 people with advanced chronic kidney disease followed for 6 months, adding folic acid (alone or with pentoxifylline) to usual care reduced fatigue scores and improved kidney blood tests compared with usual care alone.The potential adding therapeutic effect of pentoxifylline and/or folic acid for chronic kidney disease patients: randomi…
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 64 women with polycystic ovary syndrome, 10 weeks of magnesium improved the energy and fatigue score and total quality of life compared with placebo.The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 58 healthy adults with mild prolonged tiredness, a supplement combining pomegranate extract with B vitamins and vitamin C reduced fatigue scores over 8 weeks compared with placebo, though vitamin C was not tested alone and biochemical markers did not change.Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monoce…
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 49 patients after colon surgery, magnesium oxide (1 g every 12 hours) did not change fatigue or bowel recovery compared with placebo.Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double…
- In healthy young adults with low vitamin C levels, 500 mg twice a day for 4 weeks improved attention and work absorption compared with placebo, with a trend toward less fatigue.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In a 28-day placebo-controlled trial of 46 adults with long COVID, twice-daily liposomal vitamin C (500 mg) with l-arginine reduced persistent fatigue (2 of 23 still fatigued vs 21 of 23 on placebo) and improved walking distance and handgrip strength.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 40 young adults with low vitamin C, 1000 mg daily for 4 weeks improved mental vitality and reduced inflammation compared with placebo, with gut bacteria changes linked to the gains.Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitam…
- In 36 volunteers, 1 g of vitamin C daily for 30 days improved maximal oxygen uptake and lowered oxidative stress only in those with the lowest vitamin C levels, and it did not reduce fatigue index.Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
- In 33 soldiers during a 12-day tropical training exercise, folate status declined in all groups and those eating combat rations reported more fatigue than those eating fresh food; folate was not given as a separate supplement.The physiological and psychological effects of combat ration feeding during a 12-day training exercise in the tropics.
- In 32 people with chronic fatigue syndrome, weekly magnesium sulphate injections for 6 weeks led 12 of 15 treated patients to report benefit and better energy, versus 3 of 17 on placebo.Red blood cell magnesium and chronic fatigue syndrome.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 30 adults with hypertension, diabetes or high blood fats, drinking water with 80 mg of magnesium daily for 4 weeks improved body mass index, insulin, triglycerides and fatigue compared with placebo water.Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
- In 28 men with marginal vitamin C status, 1000 mg daily for 8 weeks produced a physical activity rise that was not statistically significant compared with placebo, though cold episodes were fewer.Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vit…
- In 26 overweight middle-aged women doing aerobic training for 3 months, drinking 500 mL of orange juice daily was linked with lower blood lactate, suggesting less muscle fatigue than training alone.Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training.
- Eating two SunGold kiwifruit daily for 4 weeks improved mood disturbance, wellbeing and vitality compared with usual diet in 26 adults with mild to moderate mood disturbance.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 25 healthy young adults, a single dose of a pre-workout drink containing 500 mg vitamin C along with other ingredients raised self-rated energy and vigour compared with placebo, though adding synephrine gave no extra benefit.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 breast cancer survivors, 500 mg vitamin C plus vitamin E daily for 10 weeks alongside strength training did not reduce fatigue more than placebo.Effect of strength training and antioxidant supplementation on perceived and performance fatigability in breast cancer s…
- In 25 resistance-trained people, a week of a pre-workout drink containing 45 mcg B12 and other ingredients helped maintain some strength and lifting measures versus placebo but did not change cycling time trial performance.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 22 college-aged adults taking 350 mg of magnesium daily for 10 days, muscle soreness and perceived recovery improved compared with placebo, but performance gains did not reach statistical significance.Effects of Magnesium Supplementation on Muscle Soreness and Performance.
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during exercise compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 20 junior cyclists, a daily multi-nutrient tablet containing magnesium for 4 weeks led to faster fatigue recovery than a plain vitamin product, but magnesium was not tested alone.Studies concerning the ergogenic value of Cantamega-2000 supply in top junior cyclists.
- In 18 healthy volunteers, 1000 mg a day of ascorbic acid for 8 days did not reduce physical fatigue during a long cycling task, while a different product did.Effects of Applephenon and ascorbic acid on physical fatigue.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 17 people doing hard cycling at high altitude, a 3-week broad antioxidant capsule that included vitamin C did not improve performance; a different supplement combination did better than both this capsule and placebo.Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.
- In 16 trained men with two nights of short sleep, zinc magnesium aspartate had no effect on sleep, ratings of fatigue or morning weightlifting performance compared with placebo.Effects of Supplementing Zinc Magnesium Aspartate on Sleep Quality and Submaximal Weightlifting Performance, following T…
- In 15 people with chronic fatigue syndrome, injected liver extract with folic acid and vitamin B12 did not improve fatigue-related function more than placebo, and the placebo response was strong.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In 14 healthy volunteers, 3000 mg a day of ascorbic acid for 8 days did not change physical fatigue during a long cycling task compared with placebo.Daily oral administration of crocetin attenuates physical fatigue in human subjects.
- In 12 middle-aged triathletes during a 90-minute cycling session, taking vitamin C with glutathione improved energy-related metabolic and heart measures and lowered an oxidative stress marker compared with placebo, though vitamin C was not tested alone and this was a single acute session.Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Perf…
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In eight men, a glucose drink lowered blood potassium during and after intense cycling, but it did not delay fatigue compared with placebo.A single oral glucose load decreases arterial plasma [K+ ] during exercise and recovery.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In 7 well-trained runners, drinking a prescribed volume of a potassium-containing carbohydrate-electrolyte drink during 4 hours of recovery from a long run let them keep running about 16% longer later than drinking as much as they wanted.Influence of fluid intake pattern on short-term recovery from prolonged, submaximal running and subsequent exercise capa…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In people with fibromyalgia, 100 mg of magnesium daily for one month did not change fatigue more than placebo.Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinica…
- In 155 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks only marginally improved mood until day 12, with effects weaker than kiwifruit, though mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 73 children and young people with mild thalassemia, 3 months of carnitine with or without 1 mg a day of folic acid reduced bone pain and muscle weakness, but the benefit was attributed to carnitine and fatigue was not reported separately.Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects.
- In 92 patients with high blood pressure, magnesium at 320 mg a day reduced some complaints such as nervousness and sleep problems but had no effect on mental or physical fatigue.[Level of total and ionized magnesium fraction based on biochemical analysis of blood and hair and effect of supplemente…
- In 61 hemodialysis patients, 100 mg of intravenous vitamin C after each session for 6 months did not improve energy-related quality of life or red blood cell production compared with no vitamin C.Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- In 8 people with COPD, a single 2 g IV vitamin C dose compared with saline reduced quadriceps neuromuscular fatigue and lowered inflammatory C-reactive protein during exercise, but did not improve breathlessness or exercise tolerance.Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise…
- Eight healthy young men taking 6 grams of potassium-magnesium aspartate over 24 hours before a hard cycling test lasted about as long to exhaustion as those given placebo, so no endurance benefit was seen.The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise …
- In 7 male triathletes, 6 weeks of a daily antioxidant capsule containing 600 mg ascorbic acid did not change maximal oxygen uptake or muscle fatigue compared with placebo.No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabo…
- In 214 outpatients with COVID-19, 8000 mg ascorbic acid for 10 days did not shorten symptoms, including fatigue, compared with usual care.Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulator…
- In an open-label trial of 40 head and neck cancer survivors, 100 mg vitamin C tablets daily for 8 weeks gave less fatigue relief than Tualang honey.Effects of Tualang Honey on Cancer Related Fatigue: A Multicenter Open-label Trial of H&N Cancer Patients.
- In 39 advanced cancer patients with cachexia, a 4-month combined treatment including 500 mg daily vitamin C improved fatigue scores and lowered inflammatory markers, but the study had no placebo group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In breast cancer patients taking 400 mg of magnesium oxide daily for 4 weeks, fatigue was significantly reduced, though this single-group pilot study had no placebo comparison.A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients.
- In a small uncontrolled pilot of 23 iron-deficient women, a daily food-derived supplement that also contained vitamin C was taken for 8 weeks, and self-reported energy improved, though vitamin C alone was not tested and there was no placebo group.A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Def…
- In a large cohort of about 81,500 women aged 60 and older followed for a median of 16 years, higher magnesium intake was linked to a lower risk of frailty, with the top fifth of intake showing 12% lower risk than the bottom fifth.Total magnesium intake and risk of frailty in older women.
- In a survey of complementary medicine practitioners giving IV vitamin C (average 28 g every 4 days), 59 of 9,328 patients with data had lethargy or fatigue as a side effect, and most side effects were minor.Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In 1,643 Spanish adults aged 65 and over followed for about 3.5 years, low dietary vitamin C intake was linked to a higher risk of frailty, which includes exhaustion, but this link was not statistically significant on its own.Low vitamin intake is associated with risk of frailty in older adults.
- In a 90-day follow-up of 923 Indonesian COVID-19 survivors, vitamin C combined with other micronutrients and favipiravir did not significantly change post-COVID symptoms, including fatigue, which was the most common symptom.Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: A longitudinal study.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In a survey of 576 people in Syria who had COVID-19, 76.4% reported using vitamin C, but the survey did not measure whether vitamin C improved energy or fatigue, and fatigue was the most reported symptom.COVID-19 infected patients' experiences in Syria, and the role of the pharmacists during their infection.
- Older adults with fatigue had higher blood folic acid than those without fatigue, and lower vitamin D tracked with more fatigue; this study did not test folate supplements.Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
- In 411 dentists and their wives, people who took little vitamin C reported about double the number of fatigue symptoms compared with those who took more.Daily vitamin C consumption and fatigability.
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- In a retrospective German cohort of 125 breast cancer patients, adding intravenous vitamin C of 7.5 g for at least 4 weeks was associated with fewer treatment side effects, including fatigue, than no added vitamin C.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- In 101 people with relapsing multiple sclerosis, lower dietary folate intake was linked to higher fatigue scores, but this cross-sectional study cannot show cause.Dietary intake of nutrients and its correlation with fatigue in multiple sclerosis patients.
- Red blood cell magnesium was normal in 89 people with chronic fatigue syndrome, and a magnesium loading test in 6 of them found no deficiency, so the authors saw no reason to use magnesium treatment for this condition.Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome.
- In a retrospective chart review of 86 cancer patients given high-dose IV vitamin C (50 to 150 g per infusion), patients overall reported improved fatigue, pain, and mood, with temporary nausea and injection-site discomfort as the most common side effects.Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.
- In 67 adults with shingles, about 2 weeks of intravenous vitamin C alongside standard treatment was followed by reduced pain and less general fatigue, but the study had no placebo group.Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- Half of 60 people with chronic fatigue syndrome had low serum folate levels, but this survey did not test whether folate supplements improve energy.Serum folate and chronic fatigue syndrome.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia, those who rated themselves much improved had taken more vitamin B12 injections and higher daily folic acid for longer, though this was not a controlled test.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
Review Totals and Summary
Members Only342 reviews · 90% positive
342 reviews · Google Shopping 342
90% positive0% neutral10% negative
Customer feedback on Hyper Shock Rage is mostly positive. Buyers say it works quickly, and some reports put the onset at 10–15 minutes. Many say the flavor is a highlight. Some call it tasty enough to drink like candy, though one reviewer found the blue raspberry version a little sour. Energy is the most common praise. Reviewers describe strong, sustained focus and drive, and several say the time-released caffeine means little or no jitteriness or crash afterward. One user liked that they could work through the day without feeling burnt out. Pump is the other recurring theme. Several people describe a lasting pump that builds about 30 minutes in and gets stronger through the workout. Some credit the carbs for it. A few say the pump was only moderate, and some wanted more beta-alanine, so they added their own. Complaints are consistent. The first is tolerance and side effects at full doses. One young user took two scoops and had itching, heat waves, shakiness and a feeling of nearly blacking out. They did much better on half a scoop. The itching and tingling are typical of beta-alanine, and reviewers advise starting low. The second is cost and dosing. Heavier lifters are told to use two scoops, which one reviewer said makes it an expensive pre-workout. The third is the lack of transparency. Users and expert reviewers dislike the proprietary blends because the actual doses can't be known. Sites such as Muxcle and LeanBulking rated the formula as average or below average, with concerns about under-dosing or hidden stimulant levels. Some others said the energy was only "okay" compared with harder-hitting pre-workouts. Reviewers who tested the caffeine-free version also liked it. They found the pump matrix impressive, with good endurance and natural energy. Some noted the tingles arrive without any stimulant lift. Finally, the Electric Orange flavor itself has almost no individual reviews. Most feedback covers the Hyper Shock Rage line in general, or the blue raspberry and fruit punch flavors. Retailers now list the Electric Orange tub as permanently discontinued.
Biohacker Summary
Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it
Magnesium is the main ingredient, and the panel leans favorable: about four of the ten use it and several others recommend it, mostly for sleep, with others citing muscle function, cramps, blood pressure, migraines and workout performance. Three of them take 400 mg of the threonate form before bed, one takes the glycinate form every night, and one suggests threonate and two other forms for deep sleep. Doses vary widely, from 30 mg in electrolyte cans up to about a gram of supplemental magnesium for one panelist, and others pair it with sodium and potassium in electrolyte drinks. One panelist warned that labels can overstate the real magnesium dose, especially for citrate, and another said it does not fix waking during the night. Folate, potassium and vitamin C are smaller ingredients in this product.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
- Notes that some people may need a little bit extra folate with a supplement.
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Recommends taking vitamin C for better skin health.
- States that magnesium can affect how the body responds to a supplement.
- States that folate can affect how the body responds to a supplement.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Recommends methylfolate as a better option than folic acid.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- States that people need more potassium than any other mineral, yet most people aren’t getting enough.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Explains that the normal requirements for potassium are 4,700 mg every single day, and that very few people get half of that amount. They describe potassium's role in the sodium potassium pump, which is essential for cellular electricity, muscle contraction, and heart function. Deficiency can lead to tiredness, muscle cramps, heart palpitations, or rising blood pressure.
- Recommends increasing potassium to restore balance and support healthy blood pressure.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends Vitamin C as a cofactor, especially for collagen.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends methylfolate as an active form of folate that the body can use directly without conversion.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists potatoes and fruit as sources of Potassium.
- Lists dairy and sardines as sources of Calcium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes a multivitamin every day for longevity.
- Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Mentions potassium as an electrolyte.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
RAL Summary
Members OnlyTier 3 for Energy
The tier rests on an 80% improvement figure that comes from magnesium injections in chronic fatigue syndrome, not a drink powder, while oral magnesium trials are split (7 improved, 9 no effect) and the 20 g main blend has no studies, so the human evidence is not a clear improvement. So it is graded Tier 3, lower than the rules alone gave.
Where the evidence disagrees: 64 of the 118 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Muscular system, Cardiovascular system, Skin
Combine with: For the product's actual purpose (pre-workout energy and performance), it pairs well with creatine monohydrate for strength and power, L-citrulline or citrulline malate for pump and blood flow, and electrolytes (sodium, potassium, magnesium) for hydration. L-theanine can smooth caffeine's jitters, and a protein or EAA/BCAA supplement supports recovery. Take it with food if it upsets your stomach and avoid late-day use to protect sleep. If you need fast heartburn relief, use a separate product such as calcium carbonate antacid, an alginate (sodium alginate) or a short course of an H2 blocker, and consult a healthcare professional if symptoms are frequent.
Possible side effects: Reviewers report itching, tingling, heat waves, shakiness and nearly blacking out at two scoops, and do better on smaller doses. In one study, a low-salt, high-potassium diet was linked to more fatigue.
Supplement Facts
Carbohydrates 12 g · Vitamin C 500 mg · Vitamin B6 30 mg
Supplement Facts
Serving Size 11-66 Gram(s)
Servings Per Container 40
Amount Per Serving% Daily Value
| Calories | 50 | |
| Carbohydrates | 12 g | † |
| Protein | 0 g | |
| Vitamin C | 500 mg | |
| Vitamin B6 | 30 mg | |
| Folate | 500 mcg | |
| Vitamin B12 | 225 mcg | |
| Calcium | 80 mg | |
| Magnesium | 175 mg | |
| Sodium | 25 mg | |
| Potassium | 25 mg | |
| HYPERSHOCK(R) Proprietary Blend | 20 g | † |
† Daily Value not established.
Other ingredients: Natural & Artificial flavors, Sodium Bicarbonate, Beta-Carotene, Magnesium Oxide, Sucralose, Xanthan Gum, Guar Gum, Carrageenan.
Directions: Before first use, open container and remove scooper. Securely close container, turn upside down and shake vigorously for approx. five seconds, or until contents are 100% free flowing. Product is now ready for use. Follow dosing chart below. DIRECTIONS FOR USE: As a dietary supplement, mix 1-3 scoops with 6-18 oz water and drink 10 minutes before exercising, on an empty stomach. To assess your tolerance, start with ½ the recommended serving size for your first few workouts. Stack with AMINO2(R) during your workout & AFTERSHOCK(TM) immediately post workout for best results. RECOMMENDED DOSING CHART: MEN: Up to 155lbs: 1-1 1/2 scoops - 155 to 225lbs: 1 1/2 - 2 scoops - 225 to 275lbs: 2 - 2 1/2 scoops - 275lbs and above: 3 scoops MAX! WOMEN: Up to 115lbs: 1/2 to 1 scoop - 115lbs to 155lbs: 1 to 1 1/2 scoops - 155lbs and above: 1 1/2 to 2 scoops MAX!
Barcode (UPC) 680269382477 · Label source: NIH label database · Report a label change
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Our articles on this subject
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
- Magnesium Glycinate vs Threonate: Which Form Is Right for You?Article · Nov 6, 2026
Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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