Nature Made 3-In-1 Joint Comfort Capsules Review
Product Focus: Joints and MobilityAlso covers:Immune system
Tier ⓘ
Tier 4 · Rank 9
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 9 within Tier 4 for Joints and Mobility; 54 of 64 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only49 human studies · 41 improved
49 human studies41 improved4 no effect23,911 people studied
This product itself was tested in a human study.
This exact product has been tested in one well-designed human trial. In 2025, 157 active adults aged 40 to 60 with knee or lower back discomfort took 200 or 400 milligrams daily of the Muvz blend of chaste tree and ginger, or a placebo, for 90 days [1]. Both doses improved overall muscle and joint health, joint discomfort, range of motion and quality of life compared with placebo, and the higher dose worked better [1]. This product gives the lower 200 milligram dose. No other independent study has confirmed it yet. Boswellia, at 100 milligrams here, matches the dose used in many studies. A review of 49 trials found that 100 milligrams of an enriched extract for 90 days cut knee arthritis pain and improved function compared with placebo [2]. A 2025 pooled analysis ranked Boswellia highest of seven supplements for pain and stiffness, with no added side effects [3]. In a 180 day trial, 100 milligrams daily improved pain and function and increased cartilage thickness on scans [4]. A 30 day trial found benefits as early as day 5 [5]. One large analysis rated the evidence quality as very low, even though it found a strong effect on pain [6]. Animal and cell studies are never counted.
See all 49 studies →Hide the studies
- In a review of 49 trials in people with osteoarthritis (5980 people overall), 90 days of 100 mg enriched Boswellia serrata extract cut pain by about 17 points on a 100-point scale and improved function compared with placebo.Oral herbal therapies for treating osteoarthritis.
- In a pooled analysis of 39 trials of 4599 adults with knee osteoarthritis across seven supplements, Boswellia improved pain, stiffness and function more than placebo and ranked highest for pain and stiffness, with no added side effects.Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.
- In a review of Ayurvedic treatments for osteoarthritis (2952 people overall), Boswellia serrata showed no significant effects once the risk of biased study methods was taken into account.Ayurvedic interventions for osteoarthritis: a systematic review and meta-analysis.
- In a review of herbal medicines for osteoarthritis (1741 people overall), Boswellia serrata from two trials worked better than placebo and valdecoxib for pain and physical function, though overall evidence quality was low.Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: A systematic review and meta-analysis.
- In a pooled analysis of 20 trials with 1633 people with knee osteoarthritis, modified Boswellia serrata formulations improved pain, stiffness and knee function compared with other treatments, with no difference in side effects.Evaluating the efficacy and safety of Curcuma longa, Boswellia serrata, and their mixed formulation in treating knee ost…
- In a pooled analysis of 13 trials (up to 1185 people with knee osteoarthritis), the overall effect of Boswellia was not significant because the studies differed so much, but subgroup analysis showed lower joint symptom scores than placebo.Efficacy of Extracts of Oleogum Resin of Boswellia in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta…
- In a pooled analysis of 11 trials with 1009 people with knee osteoarthritis, Boswellia and curcumin products relieved pain and improved function more than placebo with no safety differences, though study quality was low.Efficacy of curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis.
- In a pooled analysis of 9 trials with 712 people with osteoarthritis, Boswellia serrata lowered pain, stiffness and function scores versus control, with the Aflapin extract showing larger reductions than other Boswellia products.Efficacy evaluation of standardized Boswellia serrata extract (AflapinⓇ) in osteoarthritis: A systematic review and sub-…
- In a pooled analysis of seven trials with 545 people with osteoarthritis, Boswellia and its extract reduced pain and stiffness and improved joint function compared with control, with at least 4 weeks of treatment recommended.Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis.
- In a pooled analysis of 69 trials of 20 supplements for hand, hip or knee osteoarthritis, Boswellia serrata extract had a large, clinically important short-term pain-reducing effect versus placebo, though evidence quality was very low.Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
- A review of seven randomized trials, including some in osteoarthritis and rheumatoid arthritis, found Boswellia serrata extracts were clinically effective in all trials with no serious safety issues, but the evidence was encouraging rather than compelling.Frankincense: systematic review.
- A review of randomized trials of complementary treatments for osteoarthritis found some consistent evidence that Indian Frankincense may be effective, though the number of trials was small.Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic r…
- A review of frankincense research reported that clinical trials showed benefit against osteoarthritis and other inflammatory conditions, with only mild side effects.Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
- In a 6-month trial of 440 adults with knee osteoarthritis, an Ayurvedic herbal formula containing Boswellia significantly reduced knee pain and improved knee function, and performed about as well as glucosamine and a med.Read the study on PubMed (23365148) →
- In 201 adults with osteoarthritis, a curcumin product with 450 mg daily boswellic acid for 12 weeks improved joint pain and physical performance more than placebo, and was more effective than curcumin alone.Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, do…
- In 162 adults with hand osteoarthritis, a combined turmeric and Boswellia tablet taken daily for 3 months reduced pain more than placebo, with a difference of 8.5 mm on a 100 mm scale, and no significant difference in adverse events.Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomize…
- In 157 physically active adults aged 40-60 with knee or low-back discomfort, 200 mg or 400 mg daily of a vitex and ginger blend for 90 days improved overall musculoskeletal health, joint discomfort, range of motion and quality of life compared with placebo, with the higher dose working better.A Randomized Placebo-Controlled Dose-Response Trial of Muvz™ for Knee and Low-Back Support in Physically Active Adults.
- In a 90-day placebo-controlled trial of 150 adults aged 40 to 75 with early knee osteoarthritis, BOSMAX Boswellia serrata extract significantly improved knee symptoms and lowered inflammatory markers compared with placebo.Clinical Benefits of Boswellia Serrata (BOSMAX®) in Early Knee Osteoarthritis: A Randomized, Placebo-Controlled, Double-…
- In an 8-week placebo-controlled trial of 120 adults over 40 with persistent knee pain, Boswellia extract alone improved sleep latency, while the Boswellia plus omega-3 combination improved quality of life, though pain reduction was shown mainly for the omega-3 product.Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Th…
- In 106 adults with hand osteoarthritis, a daily supplement containing 250 mg Boswellia serrata extract for 12 weeks did not reduce hand pain more than placebo.Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an intern…
- In 105 adults with knee osteoarthritis, 200 mg per day of an herbal blend containing Boswellia serrata gum resin for 90 days gave significant pain relief and better physical function compared with placebo, with benefit seen as early as 14 days.A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving J…
- In a multicenter trial of 88 adults with knee osteoarthritis, adding Loxacon capsules containing Boswellia to physical therapy roughly doubled functional improvement at 5 weeks and made clinical improvement about three times as likely.Investigating the Additive Effects of Loxacon® Food Supplement Capsules in Patients with Knee Osteoarthritis. A Multicen…
- In 84 adults with knee osteoarthritis, a daily complementary medicine combination containing 250 mg Boswellia serrata extract for 12 weeks relieved pain no better than placebo.Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, pl…
- In a placebo-controlled trial of 80 people with mild to moderate knee osteoarthritis, 100 mg daily of a standardized Boswellia extract for 180 days improved pain and joint function, increased cartilage volume and thickness on MRI, and lowered inflammatory and cartilage breakdown markers compared with placebo.A Standardized Boswellia serrata Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with …
- In a 90-day placebo-controlled trial of 75 adults with knee osteoarthritis, 100 mg daily of 5-Loxin, a Boswellia extract, significantly reduced pain and improved physical function compared with placebo, and it was safe.A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthrit…
- In 75 adults with knee osteoarthritis, capsules of Elaeagnus fruit extract alone or with Boswellia resin extract for 4 weeks reduced pain and improved function about as well as a med, with no significant difference between groups.Read the study on PubMed (28349271) →
- In a placebo-controlled trial of 70 people with knee osteoarthritis, 100 mg of Aflapin daily for 30 days reduced pain and function scores and lowered inflammatory markers compared with placebo, with no significant adverse effects.Efficacy and Safety of Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis of the Knee: A Sh…
- In a 4-week placebo-controlled trial of 70 adults with knee osteoarthritis, a frankincense extract oil rubbed onto the knee three times daily reduced pain and improved function more than placebo.Evaluation of the effectiveness of topical oily solution containing frankincense extract in the treatment of knee osteoa…
- In a randomized trial of 70 people with knee osteoarthritis, one daily capsule of Artneo for six months was not inferior to glucosamine and chondroitin for improving WOMAC scores, with a greater reduction in stiffness and synovitis on MRI but no difference in pain.[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins…
- In a placebo-controlled trial of 62 people with knee osteoarthritis, 90 days of Boswellia serrata gum resin (300 mg) combined with celery seed extract reduced pain, stiffness and swelling and lowered inflammatory and cartilage breakdown markers compared with placebo.Efficacy and Safety of Boswellia serrata and Apium graveolens L. Extract Against Knee Osteoarthritis and Cartilage Degen…
- In a 90-day placebo-controlled trial of 60 adults with knee osteoarthritis, 100 mg daily of Aflapin, a Boswellia gum resin product, significantly reduced pain and improved physical function compared with placebo, with improvements seen as early as day 7.Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomiz…
- In a randomized, placebo-controlled trial of 60 people with knee arthritis, 60 days of boswellic acids (7.2 mg) with methylsulfonylmethane (5 g) daily did not improve pain or joint function beyond placebo and initially worsened pain, but it significantly reduced the need for meds.The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
- In a 30-day placebo-controlled trial of 60 adults with knee osteoarthritis, 100 mg daily of Aflapin, a Boswellia serrata gum resin extract, significantly reduced pain and improved physical function, with benefits seen as early as day 5.A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with o…
- In 60 people with early knee osteoarthritis, a daily tablet containing Boswellia serrata extract with hyaluronic acid improved knee scores and reduced pain over 3 months, similar to hyaluronic acid injections, though the study had no placebo group.Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis…
- In an 8-week placebo-controlled trial of 60 adults with mild to moderate knee osteoarthritis, 100 mg daily of a standardized Boswellia extract significantly reduced pain, stiffness and total WOMAC score, lowered high-sensitivity CRP, and was well tolerated.High potency and water dispersible Boswellia extract reduces pain and inflammation in subjects with osteoarthritis of th…
- In a placebo-controlled trial of 48 people with knee osteoarthritis, 120 days of a Boswellia serrata extract reduced pain and stiffness and lowered high-sensitivity C-reactive protein compared with placebo, with no serious adverse events.A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serra…
- In a randomized, placebo-controlled crossover trial of 42 people with osteoarthritis, a three-month course of a herbal and zinc formulation containing Boswellia significantly reduced pain and disability scores compared with placebo, though X-ray changes were not significant.Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study.
- In an 8-week randomized crossover trial of 30 adults with knee osteoarthritis, Boswellia serrata extract reduced knee pain, improved knee flexion and walking distance, and decreased swelling compared with placebo, with no radiological change.Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind…
- In 30 people with knee osteoarthritis, a turmeric and Boswellia formulation at 500 mg twice daily was safe and gave better symptom scores than a med 100 mg twice daily.Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee o…
- In a double-blind trial of knee osteoarthritis over two months, both solid lipid Boswellia particles and standard Boswellia gum extract improved pain and WOMAC scores, but only the lipid form lowered inflammatory cytokines and reduced the need for rescue meds more.Double-blind trial of solid lipid Boswellia serrata particles (SLBSP) vs. standardized Boswellia serrata gum extract (BS…
- In more than 260 people with rheumatoid arthritis, a special Boswellia extract called H15 reduced joint swelling, pain and stiffness compared with placebo, with the study duration not stated in the summary.Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis.
- In an uncontrolled three-month study of 232 adults with hand osteoarthritis, a daily food supplement containing 120 mg Boswellia serrata resin and Curcuma longa reduced hand pain and the number of painful joints, and 64% of participants reduced their anti-inflammatory meds intake.Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial.
- In an uncontrolled six-week study of 153 adults with joint degeneration and muscle weakness, a topical herbal preparation containing Boswellia serrata lowered muscle enzyme levels and pain scores.Management of muscular dystrophy during osteoarthritis disorder: A topical phytotherapeutic treatment protocol.
- In a two-month study of 56 adults with osteoarthritis, 6 g daily of Boswellia serrata resin capsules, taken with or without a topical ointment, produced symptom improvement in both groups.Clinical evaluation of Boswellia serrata (Shallaki) resin in the management of Sandhivata (osteoarthritis).
- In a pilot study of 49 adults with various forms of osteoarthritis taking a boswellia and bromelain supplement for 1 to 6 months, quality of life scores improved significantly at about 3 months, with no adverse events reported.Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients w…
- In a 14-day case study of 13 adults with chronic musculoskeletal pain taking a blend that included boswellia, pain scores fell from an average of 58 to 23 and movement ability improved, with no adverse effects reported.Five Herbs Plus Thiamine Reduce Pain and Improve Functional Mobility in Patients With Pain: A Pilot Study.
- In a four-week registry of 55 adults with knee osteoarthritis, those taking a standardized Boswellia extract alongside standard care had greater improvements in pain, stiffness and walking distance than those on standard care alone.FlexiQule (Boswellia extract) in the supplementary management of osteoarthritis: a supplement registry.
- In a six-month registry of 54 adults with moderate knee osteoarthritis, those taking a Boswellia, ginger and glucosamine supplement alongside standard care had better function and walking distance, and lower inflammatory markers and reactive oxygen species.Movardol® (N-acetylglucosamine, Boswellia serrata, ginger) supplementation in the management of knee osteoarthritis: pre…
- In an observational study of 118 adults with painful knee osteoarthritis taking 1 to 4 capsules a day of a boswellia, turmeric and red algae blend for about 90 days, 64.5 percent were pain-relief responders by day 90, and 35.1 percent used meds versus 59.2 percent at baseline.Clusters of Responders and Predictive Factors for Response to Supplementation with Boswellia, Turmeric, and Red Algae Ex…
Review Totals and Summary
Members OnlyWhat buyers say
No written reviews read yet.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Six of the ten panelists spoke about Boswellia, the main ingredient, and four of them currently recommend it, mostly as an anti-inflammatory for joints and general inflammation. Several say it works on a separate inflammatory pathway that other supplements such as curcumin miss, and some call it a natural alternative to meds for joint pain. One panelist cites it for injury recovery, another has used it for years for joints and the brain, and one takes it in a mix of joint helpers, with a joint formula suggested on an empty stomach. Pairings named include turmeric, celery seed, ginger, white willow bark, hyaluronic acid and proteolytic enzymes, but no one gave a dose. One panelist warns that it gave them muscle pain, and another stays neutral, treating it as one tool to use when an inflammation problem shows up.
See all 7 biohackers →Hide the biohackers
Andrew Huberman · Boswellia · recommends
- States that Boswellia, an Indian frankincense extract, has the most evidence among other supplements for TBI recovery, having shown some benefit in three clinical trials.
- Mentions Boswellia as having some potential benefit for inflammation, but notes it's not typically used unless in very specific circumstances like an injury.
Thomas DeLauer · Boswellia · recommends
- Recommends boswellia as a runner-up for inflammation, noting it inhibits 5-LOX, an enzyme targeting a separate inflammatory pathway that curcumin misses.
Dr. Eric Berg · Boswellia · recommends
- Recommends Boswellia, stating it targets the 5-LOX pathway, also known as the backup inflammatory alarm system.
- Recommends Boswellia serrata as an amazing supplement that research has shown to be as effective as meds without side effects for joint pain.
- Recommends Boswellia as a great COX 2 inhibitor that can mimic meds without the side effects.
- Mentions a study showing that a combination of turmeric, spirulinum, and boswellia significantly reduced thyroid nodules.
- Recommends boswellia as a very good anti-inflammatory.
Dave Asprey · Boswellia · recommends
- Highlights a specialized blend of boswellia and celery seed for reprogramming inflammation.
- Has used boswellia for many years and notes its positive effects on joints and even the brain, calling it a beautiful herb.
- Agrees with the guest that boswellia would be beneficial for a dog with a spinal injury to mitigate inflammation and promote healing.
- Dave Asprey suggests that if one could throw some Boswellia in, they would probably like it.
- Lists boswellia as one of the things that affect and modulate IL-6.
- Recommends boswellia as a natural remedy for inflammation.
Siim Land · Boswellia · warns
- Experiences muscle pain from Boswellia, similar to berberine and meds.
Ben Greenfield · Boswellia · neutral
- Mentions Boswellia as another tool used to address inflammatory issues.
- Uses Boswellia as one of the tools to apply when an inflammatory issue is identified.
- Recommends Kion Flex, a joint formula with proteolytic enzymes, Boswellia, hyaluronic acid, white willow bark, turmeric, and ginger, especially for injuries, nagging aches, and pains, to be taken on an empty stomach.
- Recommends boswellia as a natural anti-inflammatory alternative to meds.
- Ben takes boswellia, which knocks out joint pain, as part of a 'shotgun mix' for his joints.
- Uses Kion Flex, taking about 12 capsules if injured or 8 to 12 daily for maintenance, as it contains a variety of antioxidants, polyphenols, glucosamine, chondroitin, collagen precursors, proteolytic enzymes, minerals, boswellia, white willow bark, hyaluronic acid, turmeric, ginger, and cherry juice for joint support.
- Ben Greenfield highly recommends Kion Flex for hair, skin, nails, reducing soreness with proteolytic enzymes, and its unique mineral blend including phosphorus, cherry juice, ginger, turmeric, white willow bark, hyaluronic acid, and boswellia (frankincense).
- Ben Greenfield lists boswellia as part of Roger Drummer's anti-cancer blend.
- Mentions Boswellia as an ingredient in Phenocane that helps with limiting soreness and controlling inflammation.
- Ben mentions that Phenocane contains boswellia, a natural herbal anti-inflammatory with pharmacological effects that help shut down pain.
Dr. Mark Hyman · Boswellia · recommends
- Recommends Boswellia as an anti-inflammatory herb.
RAL Summary
Members OnlyTier 4 for Joints and Mobility
Studies support both ingredients at full dose, and one trial tested this exact blend [1][2]. With no reviews counted, the product cannot rank above emerging.
This product itself was tested in a human study.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 4 of the 49 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Immune system
Possible side effects: Boswellia studies found no added side effects compared with placebo. No major side effects reported.
Supplement Facts
Muvz™ Extract Blend 200 mg · Boswellia Gum Resin Extract 100 mg
Supplement Facts
Serving Size 1 Capsule
Amount Per Serving% Daily Value
| Muvz™ Extract Blend | 200 mg | † |
| Boswellia (Boswellia serrata) Gum Resin Extract | 100 mg | † |
† Daily Value not established.
Other ingredients: Hypromellose, Dicalcium Phosphate, Magnesium Stearate, Less than 2% of Cellulose Gel, Silicon Dioxide.
Directions: Adults, take 1 capsule daily with water.
Barcode (UPC) 031604006914 · Label source: Reverseagelab · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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