Nature Made B-Complex Review

Product Focus: Occasional Heartburn: Fast ReliefAlso covers:DigestionRanked among:Vitamin B complex
Tier ⓘ
Tier 4 · Rank 7
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 7 within Tier 4 for Occasional Heartburn: Fast Relief; 16 of 27 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only15 human studies · 8 improved

2 of these 15 human studies gave the ingredient by drip or injection, not by mouth.

15 human studies8 improved5 no effect20,607 people studied

No study given here tested this product, or any of its vitamins as a swallowed supplement, for fast relief of occasional heartburn. Vitamin C helped only with irritation from an iodine stain sprayed during throat cancer screening, not everyday heartburn [1][2]. In a small trial, vitamin C mixed with nitrous acid in the stomach actually raised acid reaching the throat [3]. Diets higher in vitamin C were linked to less reflux disease, but these surveys did not test pills [4][5]. Thiamine eased ongoing indigestion in one trial, but it was injected into acupuncture points rather than swallowed [6]. Diets higher in riboflavin were linked to lower odds of reflux, which shows a link only, not that it works [7][8]. Vitamin B6 results disagree. A blend with melatonin and other nutrients relieved reflux, but the effect of vitamin B6 alone cannot be separated out [9]. Diet studies found lower odds [7], higher odds [10], or no direct link with reflux [11]. A drink with vitamin B6 and other ingredients caused heartburn in 10 of 25 people [12]. Niacin and pantothenic acid have no human studies for this goal. Animal and cell studies are never counted.

See all 15 studies →Hide the studies

Review Totals and Summary

Members OnlyWhat buyers say

No written reviews read yet.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

The statements for this B-complex product are almost all about vitamin C, which is only a smaller ingredient in this product, and no one on the panel spoke about the main B vitamins as a group. Most of the panel recommends or uses vitamin C, mainly for collagen, skin, joints and immune support, and several pair it with collagen, with one suggesting taking it about an hour before a workout. Doses came up a few times: one takes an extra gram a day, another takes 250 milligrams, one cites 500 milligrams to 1 gram, and another says 2 to 4 grams, though one panelist warns the best dose is unsettled and high doses might blunt some benefits of exercise. One panelist stopped using a vitamin C serum because of its smell and noted that vitamin C taken by mouth has not been shown to protect against cataracts at above-normal levels. Niacin and vitamin B1 were each mentioned by only one or two panelists, as smaller ingredients in this product.

See all 10 biohackers →Hide the biohackers
  • Ben Greenfield · Vitamin C · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 24 Sep 2026 · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 25 Aug 2026 · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends Vitamin C for skin repair post-tattoo.
    • 25 Apr 2026 · Niacin · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 18 Apr 2026 · Niacin · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
    • 7 Mar 2026 · warns · YouTube ↗
      Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
    • 8 Jan 2026 · Niacin · neutral · YouTube ↗
      Mentions niacin as a natural approach that might be good for plaque regression.
    • 22 Nov 2025 · warns · YouTube ↗
      Warns against ascorbic acid, stating that it does not cure scurvy and that the world has been led astray by the deception around it versus the whole food vitamin C complex.
    • 16 Nov 2025 · warns · Facebook ↗
      Warns against taking 1,000 mg of vitamin C immediately after a workout for individuals under 50, as it can dull the body's natural adaptation signal.
    • 30 Oct 2025 · warns · YouTube ↗
      Warns that using high-dose antioxidants like vitamin C directly before or after a hyperbaric session is not a great idea, as it could impair some of the effects by reducing reactive oxygen species.
    • 9 Oct 2025 · warns · YouTube ↗
      Warns that taking a whole bunch of antioxidants like vitamin C after a workout can suppress the body's inflammatory response, which is necessary for benefits like mitochondrial proliferation and satellite cell generation for new muscle.
  • Siim Land · Vitamin C · recommends
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 14 Oct 2026 · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 30 Sep 2026 · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 27 Jul 2026 · neutral · X ↗
      Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
    • 27 Jul 2026 · neutral · X ↗
      States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
    • 27 Jul 2026 · recommends · YouTube ↗
      States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
    • 9 Jul 2026 · neutral · YouTube ↗
      Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
    • 4 Jul 2026 · uses · YouTube ↗
      Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
    • 15 Feb 2026 · Niacin · recommends · TikTok ↗
      Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
    • 12 Feb 2026 · Niacin · recommends · Instagram ↗
      Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
    • 17 Jan 2026 · Niacin · neutral · Instagram ↗
      Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
    • 28 Dec 2025 · Niacin · neutral · YouTube ↗
      Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
  • Dr. Eric Berg · Vitamin C · neutral
    • 26 Oct 2026 · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 24 Oct 2026 · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 23 Oct 2026 · recommends · YouTube ↗
      States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
    • 21 Oct 2026 · Vitamin B1 · recommends · YouTube ↗
      States that taking Vitamin B1 might help with swollen legs and ankles.
    • 19 Oct 2026 · Niacin · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 18 Oct 2026 · Vitamin B1 · recommends · Instagram ↗
      Dr. Eric Berg states that vitamin B1 supports the nerve function and energy production involved in the brain's response to changes in hearing, which plays a major role in tinnitus.
    • 17 Oct 2026 · recommends · YouTube ↗
      Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
    • 11 Oct 2026 · Vitamin B1 · recommends · Facebook ↗
      Dr. Berg suggests that supporting vitamin B1 intake may help address the stress behind bloating.
    • 11 Oct 2026 · Niacin · recommends · YouTube ↗
      Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
    • 10 Oct 2026 · Vitamin B6 · warns · Podcast ↗
      Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
    • 4 Oct 2026 · Vitamin B1 · recommends · Facebook ↗
      Recommends taking the fat-soluble version of vitamin B1, benfotiamine, to support blood flow to the nerves and counter complications of diabetes.
    • 4 Oct 2026 · Vitamin B1 · neutral · X ↗
      Notes that Vitamin B1 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 4 Oct 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
  • Thomas DeLauer · Vitamin C · recommends
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 29 Aug 2026 · neutral · Instagram ↗
      States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
    • 25 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
    • 19 Aug 2026 · recommends · YouTube ↗
      Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
    • 8 Aug 2026 · neutral · YouTube ↗
      Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
    • 5 Aug 2026 · Vitamin B2 · warns · Instagram ↗
      Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
    • 5 Aug 2026 · Vitamin B1 · warns · Instagram ↗
      Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
    • 29 Jul 2026 · recommends · YouTube ↗
      Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
    • 24 Jun 2026 · Niacin · neutral · YouTube ↗
      Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
  • Dave Asprey · Vitamin C · recommends
    • 24 Oct 2026 · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 14 Aug 2026 · neutral · Podcast ↗
      Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
    • 25 Jul 2026 · neutral · Facebook ↗
      Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 16 Jul 2026 · warns · YouTube ↗
      Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
    • 14 Jul 2026 · recommends · YouTube ↗
      Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
    • 9 Jul 2026 · warns · YouTube ↗
      Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
    • 14 Jun 2026 · recommends · Podcast ↗
      Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
    • 30 May 2026 · Niacin · recommends · YouTube ↗
      Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
    • 27 May 2026 · warns · YouTube ↗
      States that Ensure is like SlimFast but worse, and that its ingredients, including synthetic vitamins, guar gum, maltodextrin, high fructose corn syrup, and seed oils, are disgusting and should not be given to sick or well people.
    • 19 May 2026 · recommends · YouTube ↗
      Recommends IV Vitamin C, or even oral versions, for helping the body heal and for cells to remain supple and fluid.
    • 15 May 2026 · Niacin · neutral · X ↗
      Notes that niacin has been a standard longevity ingredient since the 1990s.
    • 17 Feb 2026 · Niacin · neutral · Podcast ↗
      Dave discusses how niacinamide compares as an NAD precursor.
  • Dr. Mark Hyman · Vitamin C · recommends
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 6 Oct 2026 · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
    • 30 Sep 2026 · neutral · YouTube ↗
      Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
    • 30 Sep 2026 · Niacin · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 14 Sep 2026 · recommends · Facebook ↗
      Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
    • 9 Sep 2026 · uses · YouTube ↗
      Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
    • 31 Aug 2026 · Vitamin B6 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends vitamin C for immune system support and modulation.
    • 22 Jul 2026 · uses · YouTube ↗
      Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
    • 29 Jun 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
    • 3 Jun 2026 · Vitamin B6 · neutral · YouTube ↗
      Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
  • Dr. Rhonda Patrick · Vitamin C · neutral
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 5 Jun 2026 · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
    • 4 May 2026 · uses · YouTube ↗
      Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
    • 5 Feb 2026 · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · neutral · Facebook ↗
      Notes that ~35% of Americans are low in vitamin C.
    • 29 Dec 2025 · recommends · X ↗
      Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
    • 9 Sep 2025 · warns · YouTube ↗
      Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
    • 4 Sep 2025 · neutral · Facebook ↗
      Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
    • 11 Aug 2025 · uses · X ↗
      Currently takes the Pure Encapsulations O.N.E Multivitamin.
    • 26 Jun 2025 · uses · Facebook ↗
      Rhonda's current supplement routine includes Vitamin C.
    • 3 Jul 2024 · Vitamin B1 · neutral · YouTube ↗
      Explains that alcohol consumption can lead to a deficiency in thiamine (Vitamin B1), which is essential for nerve function and brain health, by impairing its absorption and inhibiting its utilization.
    • 13 May 2020 · Vitamin B1 · neutral · YouTube ↗
      Notes that thiamine, a type of B vitamin, was used in combination with intravenous vitamin C and hydrocortisone in a study for sepsis patients, which decreased the risk of organ failure and death.
    • 14 Apr 2020 · Vitamin B1 · neutral · YouTube ↗
      Notes that studies suggest intravenous vitamin C alone or in combination with other treatments like thiamine can decrease the risk of organ failure and mortality in patients diagnosed with sepsis.
    • 28 Jan 2020 · Niacin · neutral · YouTube ↗
      States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
  • Andrew Huberman · Vitamin C · uses
    • 17 Jun 2026 · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 2 Feb 2026 · recommends · YouTube ↗
      Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
    • 7 Jul 2025 · uses · YouTube ↗
      Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
    • 16 Jun 2025 · uses · YouTube ↗
      Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
    • 28 Apr 2025 · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
    • 3 Feb 2025 · uses · YouTube ↗
      Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
    • 18 Nov 2024 · uses · YouTube ↗
      Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
    • 14 Oct 2024 · recommends · YouTube ↗
      Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
    • 7 Oct 2024 · Vitamin B2 · neutral · YouTube ↗
      Mentions that Riboflavin (Vitamin B2) hits cytochrome 2 in the mitochondrial electron transport chain, contributing to energy production.
    • 12 Aug 2024 · uses · YouTube ↗
      States that AG1 is the highest quality and most complete foundational nutritional supplement available, containing vitamins, minerals, probiotics, prebiotics, and adaptogens, and that he has been taking it daily since 2012, often twice a day, to bolster his energy, immune system, and gut microbiome.
    • 2 Aug 2024 · recommends · YouTube ↗
      Huberman mentions that vitamin C seems to help with the absorption or utilization of collagen protein.
    • 29 Jul 2024 · Vitamin B6 · warns · YouTube ↗
      Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
    • 1 Jul 2024 · Niacin · neutral · Instagram ↗
      Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
    • 1 Jul 2024 · Niacin · recommends · YouTube ↗
      Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
  • Peter Attia · Vitamin C · stopped
    • 3 Jul 2025 · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 6 Sep 2024 · neutral · YouTube ↗
      States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
    • 19 Aug 2024 · recommends · YouTube ↗
      Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
    • 30 Jan 2023 · Niacin · stopped · YouTube ↗
      Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
    • 7 Nov 2022 · Niacin · stopped · YouTube ↗
      Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
    • 1 Aug 2022 · Niacin · neutral · YouTube ↗
      Recalls that a flush from niacin typically occurred with doses of a few grams.
    • 13 Jun 2022 · Niacin · warns · YouTube ↗
      Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
    • 13 Jun 2022 · Niacin · neutral · Podcast ↗
      He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
    • 7 Mar 2022 · neutral · YouTube ↗
      Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
    • 24 Jan 2022 · neutral · YouTube ↗
      Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
    • 19 Oct 2020 · warns · YouTube ↗
      Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
    • 21 Sep 2020 · Niacin · warns · YouTube ↗
      States that niacin is a dead drug and is not recommended by any guidelines, though some still selectively use it for Lp(a).
  • Bryan Johnson · Vitamin C · neutral
    • 3 Feb 2025 · neutral · YouTube ↗
      Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
    • 8 Jan 2025 · uses · YouTube ↗
      Applies vitamin C after showering.
    • 26 Sep 2023 · uses · YouTube ↗
      Takes 250 milligrams of Vitamin C.
    • Date not recorded · recommends · Website ↗
      Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
    • Date not recorded · uses · Website ↗
      Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
    • Date not recorded · uses · Website ↗
      He uses Vitamin C, typically in a serum, in the morning for skin health.
    • Date not recorded · Niacin · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • Date not recorded · Niacin · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.

RAL Summary

Members OnlyTier 4 for Occasional Heartburn: Fast Relief

The evidence is thin and indirect. The studies tested other forms, such as sprays, injections or blends, or looked only at diet, and the vitamin B6 findings disagree. No reviews were available to add support.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 5 of the 15 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system

Possible side effects: In one trial, a drink with vitamin B6, inulin and menthol caused noticeable heartburn in 10 of 25 people. Vitamin C mixed with nitrous acid increased acid reaching the throat in a small study.

Supplement Facts

Vitamin C 300 mg · Thiamine 15 mg · Riboflavin 10.2 mg
Supplement Facts
Serving Size 1 Caplet(s)
Servings Per Container 100
Amount Per Serving% Daily Value
Vitamin C300 mg
Thiamine15 mg
Riboflavin10.2 mg
Niacin50 mg
Vitamin B65 mg
Pantothenic Acid10 mg

Other ingredients: Cellulose Gel, Hypromellose, Croscarmellose Sodium, Magnesium Stearate, Polyethylene Glycol.

Directions: Suggested use: Adults, take one caplet daily with water and a meal.

Barcode (UPC) 031604013387 · Label source: NIH label database · Report a label change

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Our articles on this subject

Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.