Nature Made Burp-less Fish Oil 1200 mg Review
Product Focus: Muscle and Strength
Tier ⓘ
Tier 4 · Rank 61
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 61 within Tier 4 for Muscle and Strength; 103 of 109 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
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Study, Trial or Testing Result Summary
Members Only86 human studies · 37 improved
1 of these 86 human studies gave omega-3 fatty acids by drip, not by mouth.
86 human studies37 improved26 no effect17,332 people studied
Fish oil omega-3 fats have a small and inconsistent effect on muscle, mostly in older adults and at higher doses. This product reaches a full dose at two servings a day. A pooled analysis of 16 studies in 2,438 older adults found better lower-body strength and chair-rise performance, but no change in lean tissue mass [1]. Pooling 10 trials in older adults found a small muscle gain of 0.33 kg, rising to 0.67 kg at more than 2 grams a day [2]. Across 66 trials, mostly in people with illness, omega-3 modestly increased lean mass and thigh strength, though small studies and varied results limit confidence [3]. In 200 older adults, 4 grams of fish oil a day for six months increased muscle mass, grip strength and walking speed compared with placebo [4]. However, a two-year trial of 1,054 healthy adults taking 1 gram a day found no gain in grip strength, walking speed, balance or chair stands [5], and a three-year trial of 1,680 adults aged 70 and older found no strength benefit [6]. No studies here looked at young people doing strength training. Animal and cell studies are never counted.
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- Across 16 studies of 2,438 older adults, omega-3 did not change lean tissue mass but improved lower-body strength and sit-to-stand and timed-up-and-go performance, with no gain in walking or upper-body strength.Effects of Omega-3 Supplementation Alone and Combined with Resistance Exercise on Skeletal Muscle in Older Adults: A Sys…
- Across 26 trials of 1892 cancer patients, omega-3 (EPA alone or DHA plus EPA) did not significantly change lean body mass, though DHA plus EPA improved body weight and BMI.Comparison of EPA and DHA&EPA on body weight, BMI, and lean body mass in cancer patients: a network meta-analysis.
- In 35 trials of 1211 trained athletes, omega-3 gave the greatest benefit for recovery, while creatine ranked best for muscle strength; omega-3 muscle strength results were not reported in the abstract.Comparative Effects of Dietary Protein, Creatine, and Omega-3 Supplementation on Muscle Strength, Endurance, and Recover…
- Pooled trials showed fish or fish oil reduced body weight, body fat and waist size slightly but made no difference to lean body mass or fat mass.Fish or n3-PUFA intake and body composition: a systematic review and meta-analysis.
- In 11 trials during cancer chemotherapy or radiotherapy, high-protein omega-3-enriched supplements raised body weight by 1.89 kg versus isocaloric controls, and two studies showed less loss of lean body mass.Systematic review and meta-analysis of the evidence for oral nutritional intervention on nutritional and clinical outcom…
- Pooling 10 trials in older adults, omega-3 gave a small muscle mass gain of 0.33 kg, with a larger gain of 0.67 kg at more than 2 g per day.Effects of Omega-3 Fatty Acids on Muscle Mass, Muscle Strength and Muscle Performance among the Elderly: A Meta-Analysis…
- In 31 publications of people with cancer taking at least 600 mg of omega-3 daily for at least 3 weeks, omega-3 did not change muscle mass, quality of life or body weight compared with controls, but it lowered the chance of nerve damage from chemotherapy.The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patie…
- Across 11 placebo-controlled trials, omega-3 supplementation had no significant effect on lean body mass in the pooled analysis.Supplementation with omega-3 and lean body mass in the general population: A systematic review and meta-analysis.
- Across 66 trials, mostly in people with illness such as cancer or lung disease, omega-3 supplements modestly increased lean body mass, skeletal muscle mass and thigh muscle strength compared with controls, though small studies and varied results limit confidence.The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping system…
- Across 14 trials in people with cancer, omega-3 did not significantly increase lean body mass compared with placebo (about 0.17 kg), though body weight rose slightly.Effects of omega-3 supplementation on lean body mass in cancer patients: a systematic review and meta-analysis.
- In four trials combining omega-3 with resistance training, muscle strength improved compared with placebo but muscle mass did not change significantly.Effects of Omega-3 fatty acids supplementation and resistance training on skeletal muscle.
- In 8 trials, omega-3 had no effect on muscle protein synthesis rates but increased whole-body protein synthesis.The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and m…
- In 15 trials of 461 healthy people who exercised, omega-3 did not increase muscle size or strength beyond training alone, though it improved recovery from muscle soreness and some measures of muscle function.N-3 PUFA as an ergogenic supplement modulating muscle hypertrophy and strength: a systematic review.
- A review of seven randomized trials in 192 sedentary people found that five of six studies measuring muscle size or mass showed higher values with omega-3, and both studies measuring muscle protein building rate showed benefit, though other muscle signaling and gene markers mostly showed no effect.Muscle hypertrophy induced by N-3 PUFA supplementation in absence of exercise: a systematic review of randomized control…
- In a review of 7 trials in cancer cachexia, only one trial in people at an early stage showed a clear benefit, at 2 g EPA daily but not 4 g, and lung cancer patients did not respond.Should omega-3 fatty acids be used for adjuvant treatment of cancer cachexia?
- Of 14 clinical studies on fatty acids and sarcopenia, eight reported a positive effect and six found no significant effect, so human evidence on muscle remains inconsistent.Potential of Fatty Acids in Treating Sarcopenia: A Systematic Review.
- In 20 trials of people with cancer, omega-3 with more DHA than EPA reduced inflammation more often than omega-3 with more EPA, and most body weight results for higher EPA ratios showed no benefit.Does the ratio of eicosapentaenoic acid to docosahexaenoic acid matter in cancer treatment? A systematic review of their…
- In 13 controlled trials in physically healthy adults, omega-3 supplementation over 1 day to 26 weeks lowered some post-exercise inflammation and oxidative stress markers, while muscle soreness results were mixed and doses varied widely.Omega-3 Fatty Acid Supplementation on Post-Exercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performa…
- In 1680 adults aged 70 and older taking omega-3 capsules daily for 3 years, muscle strength (chair stands and grip) did not differ from placebo.Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Interventio…
- Over two years, 1 gram of daily marine omega-3 fats did not improve grip strength, walking speed, balance or chair-stand performance compared with placebo in 1054 generally healthy adults.Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in the VITamin D and OmegA-3 Tr…
- Children whose mothers took fish oil from week 24 of pregnancy until birth had higher lean mass at age 6 than children of mothers given olive oil, though they also had higher BMI.Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.
- Children whose mothers took 2.4 g per day of omega-3s during pregnancy had slightly more lean mass at age 10 than controls, but the difference was not statistically significant.Fish oil supplementation during pregnancy, anthropometrics, and metabolic health at age ten: A randomized clinical trial…
- In 518 cancer patients losing weight, 2 or 4 grams per day of eicosapentaenoic acid for eight weeks gave no statistically significant benefit on weight, lean mass or survival compared with placebo.Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia.
- In 332 people with cancer cachexia treated for 4 months, lean body mass rose significantly only with the combination of all agents including EPA, which beat the other arms including EPA alone.Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia.
- In 241 older adults with sarcopenia, 12 weeks of a supplement combining whey protein, fish oil, and vitamin D increased muscle mass and grip strength compared with routine care, and reduced fat mass.Effects of nutrition supplementation and physical exercise on muscle mass, muscle strength and fat mass among sarcopenic…
- In 200 older Chinese adults, six months of 4 grams per day fish oil increased muscle mass, grip strength and walking speed compared with corn oil placebo.Effects of fish oil-derived n-3 polyunsaturated fatty acid on body composition, muscle strength and physical performance…
- In 191 patients after esophagectomy, feeding enriched with 2.2 g per day of omega-3 EPA did not reduce lean body mass loss compared with standard feeding.Does Prolonged Enteral Feeding With Supplemental Omega-3 Fatty Acids Impact on Recovery Post-esophagectomy: Results of a…
- In 120 adults over 40 with persistent knee pain, eight weeks of an omega-3 product reduced pain more than placebo, improved quality of life and some muscle strength measures, and sped up the Up and Go test.Efficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Th…
- Over two months, 3 grams of daily omega-3 fats did not change lean mass, fat mass or body mass index compared with placebo in 120 adults on hemodialysis, although visceral fat fell in a way that was close to significant.Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A ran…
- In 107 older adults at risk of muscle loss, 24 weeks of leucine-enriched protein with omega-3 (0.8 g EPA and 1.1 g DHA twice daily) did not improve lean mass, strength, physical performance or muscle protein building, and knee flexion strength was lower than with placebo.Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle…
- In 83 older adults at risk of sarcopenia, 24 weeks of leucine-enriched protein with or without omega-3 showed no meaningful individual differences in muscle mass, leg strength, walking speed or triglycerides beyond the control group.Interindividual variability in response to protein and fish oil supplementation in older adults: a randomized controlled…
- In 81 COPD patients with low muscle mass doing 4 months of high intensity exercise, a supplement with omega-3s, leucine, and vitamin D added modest gains in body mass compared with placebo, but both groups gained similar muscle mass and leg strength.A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD.
- In 72 children with newly diagnosed leukemia, 3 months of DHA and EPA (225 mg DHA and 45 mg EPA daily) led to less lean body mass loss than placebo sunflower oil.Pilot study on the effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on body composition in chil…
- In 64 patients with head and neck cancer, 2 grams per day of eicosapentaenoic acid for six weeks lowered inflammatory blood markers and helped preserve lean body mass compared with a standard diet.Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cel…
- In 63 healthy older women over 24 weeks, a diet rich in omega-3 fats combined with resistance training produced larger gains in fast leg power than training alone, and only that group gained lean body mass.Lower limb explosive strength capacity in elderly women: effects of resistance training and healthy diet.
- In 62 cancer patients with cachexia, adding an EPA-enriched supplement to meloxicam over 3 months did not improve body weight or lean mass more than the other treatments, though all groups improved.Comparison of three different treatment modalities in the management of cancer cachexia.
- In 62 pancreatic cancer patients receiving chemoradiotherapy, an EPA-enriched supplement preserved psoas muscle area better than normal diet, but overall skeletal muscle mass did not differ significantly, and many patients struggled to drink it.The utility of nutritional supportive care with an eicosapentaenoic acid (EPA)-enriched nutrition agent during pre-opera…
- In healthy adults aged 60 to 85 taking fish oil for 6 months, thigh muscle volume, grip strength, and 1-rep max strength rose more than with corn oil, though only 44 people finished the study.Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults.
- In a placebo-controlled trial of 60 older adults with sarcopenia, a food containing 500 mg omega-3, leucine, and a probiotic for 2 months increased limb lean mass, grip strength, and physical performance more than placebo.Effectiveness of a Novel Food Composed of Leucine, Omega-3 Fatty Acids and Probiotic Lactobacillus paracasei PS23 for th…
- In 58 patients having bariatric surgery, 2000 mg per day of omega-3 fats for 90 days did not prevent muscle mass loss or improve muscle strength or walking performance compared with sunflower oil placebo.Effects of Omega-3 Supplementation in Sarcopenia After Bariatric Surgery: A Triple-Blind Randomized Controlled Clinical …
- In 54 patients with advanced head and neck cancer receiving curative treatment, 2.7 g per day of EPA omega-3 did not produce a clear benefit on weight, body mass index, or muscle preservation compared with placebo.Nutritional impact of eicosapentaenoic acid supplementation (EPA) in patients with locally advanced head and neck cancer…
- In 53 people having esophageal cancer surgery, 2.2 g EPA daily for about 4 weeks around surgery preserved lean body mass, while the standard formula group lost 1.9 kg of fat-free mass.Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery…
- In 48 pregnant women with obesity, 2 grams per day of omega-3 from early pregnancy to delivery was linked to higher newborn lean mass and longer pregnancies than placebo.Effect of Omega-3 Supplementation in Pregnant Women with Obesity on Newborn Body Composition, Growth and Length of Gesta…
- In hospitalized patients recovering from a flare-up of chronic obstructive pulmonary disease, 1 gram per day of EPA-enriched nutrition supplement did not preserve lean body mass or muscle mass better than a standard supplement during the hospital stay.Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstr…
- In 41 untrained men taking 2 g of DHA daily for 4 weeks before and during 17 days of exercise, DHA lowered muscle damage marker CK and the inflammatory marker IL-6 after eccentric exercise but did not change strength or soreness.Docosahexaenoic acid affects markers of inflammation and muscle damage after eccentric exercise.
- In 41 adults with overweight during 8 weeks of alternate-day fasting, krill oil capsules limited lean mass and grip strength loss compared with vegetable oil placebo. Each capsule provided 191 mg EPA and 94 mg DHA, with four taken daily.Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized T…
- In 38 hemodialysis patients with protein-energy wasting, 3 months of fish-oil based intradialytic parenteral nutrition raised albumin, body weight, and dietary intake compared with dietary counselling, but muscle mass and strength did not change significantly.The beneficial effects of intradialytic parenteral nutrition in hemodialysis patients with protein energy wasting: a pro…
- In 37 elderly adults with limited mobility, 12 weeks of whey protein plus omega-3 and other bioactive capsules combined with electrical muscle stimulation raised knee strength by 13% more than a carbohydrate drink.Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Incre…
- Older adults with low muscle mass who took a daily juice drink with 3000 mg of omega-3 fats, whey protein, vitamin D and resveratrol for six months kept their grip strength and improved their physical performance test scores, while lean mass did not change and fat mass rose; this was a multi-ingredient product, not omega-3 alone.Effects of a Long Chain n-3 Polyunsaturated Fatty Acid-rich Multi-ingredient Nutrition Supplement on Body Composition an…
- In 34 sarcopenic women taking 4 g per day of fish oil or sunflower oil capsules during 14 weeks of resistance training, the fish oil group gained far more leg strength than the placebo group.Randomised Controlled Trial of Fish Oil Supplementation on Responsiveness to Resistance Exercise Training in Sarcopenic …
- In 32 older men doing home resistance band training for 12 weeks, a five-ingredient supplement including omega-3 improved lean mass, strength and muscle fiber size; omega-3's own effect was not isolated.A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Livin…
- In a retrospective analysis of older men with obesity, a collagen and safflower oil protein blend produced greater muscle and strength gains than a whey and casein blend that also contained fish oil over three months, so the omega-3 effect cannot be separated out.Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrosp…
- In 30 young women, 3200 mg a day of fish oil for three days after a resistance workout did not reduce muscle soreness or speed recovery of strength compared with olive oil placebo.Effects of omega-3 supplementation on muscle damage after resistance exercise in young women: a randomized placebo-contr…
- In 30 active young men taking 3150 mg of omega-3 daily for 8 weeks of resistance training, inflammatory markers and oxidative stress markers improved, and strength and power gains were greater than with training alone.The Effects of Omega-3 Supplementation Combined with Strength Training on Neuro-Biomarkers, Inflammatory and Antioxidant…
- In 28 boys with Duchenne muscular dystrophy, 2.9 g per day of omega-3 fats for 6 months slowed the start of muscle loss compared with sunflower oil, and fewer boys had insulin resistance at 6 months, though the muscle and fat differences were not statistically significant.Evidence of muscle loss delay and improvement of hyperinsulinemia and insulin resistance in Duchenne muscular dystrophy …
- In 28 healthy older adults, fish oil taken alongside 12 weeks of resistance training was linked to lower blood markers of inflammation (IL-6 and CRP), while training alone increased strength and resting metabolic rate.Fish oil administration combined with resistance exercise training improves strength, resting metabolic rate, and inflam…
- In 27 active young men, a single dose of high-EPA fish oil taken after a damaging workout gave better jump performance over four days than placebo, but the differences were not statistically significant.Effect of an acute dose of omega-3 fish oil following exercise-induced muscle damage.
- In 24 healthy older women, 3 g per day of fish oil for 12 weeks increased lean mass by 4% and functional capacity by 7%, while the olive oil placebo group showed no change.Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwell…
- In 24 healthy men, 8 weeks of fish oil (600 mg EPA and 260 mg DHA daily) reduced strength loss and range-of-motion loss after hard eccentric arm exercise compared with placebo, and lowered muscle soreness.Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint rang…
- In 24 healthy adults whose arm was immobilised for two weeks, daily fish oil (1770 mg EPA and 390 mg DHA) did not significantly prevent loss of muscle thickness or lean mass compared with placebo, though it blunted the increase in fat under the skin.Omega-3 Fatty Acids and Vitamin D in Immobilisation: Part A- Modulation of Appendicular Mass Content, Composition and St…
- In 23 older men doing resistance training for 12 weeks, 3 g per day of omega-3 fats did not add to gains in lean tissue mass or strength compared with placebo plus the same training.Omega-3 supplementation with resistance training does not improve body composition or lower biomarkers of inflammation m…
- In 23 healthy older adults taking about 3 g per day of omega-3 for 12 weeks of resistance training, knee strength rose more than with placebo, but muscle size and muscle growth signals did not change.Omega-3 Supplementation Improves Isometric Strength But Not Muscle Anabolic and Catabolic Signaling in Response to Resis…
- In 22 patients with advanced lung cancer, 6 grams of fish oil per day for 6 weeks improved appetite, fatigue and C-reactive protein, and adding a med also improved body weight and muscle strength.Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on syste…
- In 22 active young women, 21 days of 6 g fish oil daily did not change muscle strength or muscle damage markers after eccentric exercise compared with placebo.Effectiveness of Fish Oil Supplementation in Attenuating Exercise-Induced Muscle Damage in Women During Midfollicular an…
- In 21 young adults doing resistance training three times a week for 10 weeks, fish oil increased upper-body and relative strength more than placebo, though muscle mass gains were similar between groups.The effect of fish oil supplementation on resistance training-induced adaptations.
- In 20 resistance-trained young men on 4 g of omega-3 daily for 6 weeks with calorie restriction, loss of fat-free mass was similar to placebo, though one leg extension strength measure rose.Influence of Fish Oil-Derived n-3 Fatty Acid Supplementation on Changes in Body Composition and Muscle Strength During S…
- In 20 healthy postmenopausal women, 8 weeks of fish oil with resistance training increased handgrip strength, while resistance training with placebo did not, and fish oil also lowered inflammatory cytokines and oxidative stress markers.Fish Oil Supplementation with Resistance Exercise Training Enhances Physical Function and Cardiometabolic Health in Post…
- In 16 older women doing six weeks of supervised leg resistance training, omega-3 at 3680 mg per day increased thigh lean mass and fast-twitch muscle fiber size more than placebo, though overall strength gains were similar.Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind…
- In 15 female futsal players, a single 1000 mg fish oil and 30 g whey dose taken before muscle-damaging exercise improved lower-body strength and power and reduced muscle soreness compared with placebo.Boosting Recovery: Omega-3 and Whey Protein Enhance Strength and Ease Muscle Soreness in Female Futsal Players.
- In healthy women aged 65 to 70, 24 weeks of resistance training plus a diet lowering the omega-6 to omega-3 ratio increased leg lean mass, while resistance training alone did not.Influence of combined resistance training and healthy diet on muscle mass in healthy elderly women: a randomized control…
- In older adults, n-3 PUFA therapy caused small but coordinated changes in muscle gene expression, including increased mitochondrial pathways and decreased protein breakdown and mTOR-inhibition pathways, alongside previously reported gains in muscle mass and function.Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults.
- In overweight postmenopausal women over 16 weeks, a DHA-rich omega-3 supplement improved muscle quality in the legs but did not add to the benefits of resistance training on body composition.Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Bi…
- At age 7, children who had received higher-DHA feeds as preterm infants had the same growth, lean mass, fat mass and blood pressure as those given standard DHA, though they had a higher risk of being classified as obese.Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure …
- In postmenopausal women with overweight, 16 weeks of resistance training improved muscle quality more than DHA-rich omega-3, which improved cardiometabolic markers and may modestly help muscle function.Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA…
- In elite male sprint swimmers doing 8 weeks of race-pace training, a combined probiotic and omega-3 supplement improved explosive upper-body strength more than comparison groups, though omega-3 alone was not reported separately in the abstract.Synbiotic Supplementation with Probiotics and Omega-3 Fatty Acids Enhances Upper-Body Muscle Strength in Elite Swimmers:…
- In 45 older women doing 13 weeks of strength training, adding 2 grams per day of fish oil produced greater gains in muscle strength and chair-rising performance than training alone.Fish-oil supplementation enhances the effects of strength training in elderly women.
- In 62 women before bariatric surgery, 4 weeks of 2 g per day omega-3 fatty acids did not reduce muscle area, unlike a very-low-calorie diet, which did reduce it.Four Weeks of Preoperative Omega-3 Fatty Acids Reduce Liver Volume: a Randomised Controlled Trial.
- In 39 patients with pancreatic or biliary tract cancer receiving chemotherapy, an omega-3-rich liquid nutrition for 8 weeks increased skeletal muscle mass. The study had no control group.Effects of an enteral nutrient-rich therapy with omega-3 fatty acids in patients with unresectable or recurrent biliary …
- Nine elite female distance runners who ate 100 g of sturgeon fillet daily for 2 weeks had lower urinary markers of cell damage from oxidative stress, with blood omega-3 levels rising. The study had no control group.Effects of sturgeon fillet intake on top-ranked Japanese female long-distance runners.
- In 3,080 Korean women aged 65 and older, those getting at least the recommended amount of EPA and DHA from food had lower odds of low grip strength than those getting less. This survey study cannot show cause.Increased Omega-3 Fatty Acid Intake Is Associated with Low Grip Strength in Elderly Korean Females.
- In this cross-sectional study of 84 nursing home residents, omega-3 fat intake from food was far below recommended levels, and it did not measure muscle gain or any effect of omega-3 supplements.Assessment of Body Composition and Dietary Intake in Nursing-Home Residents: Could Lessons Learned from the COVID-19 Pan…
- In 68 colorectal cancer patients given fish oil-enriched nutrition, body inflammation decreased and skeletal muscle mass improved. The study was not randomized.Clinical Burden of Modified Glasgow Prognostic Scale in Colorectal Cancer.
- In 60 Army cadets, higher blood EPA was linked to better scores on some fitness tests, including plank and deadlift, while DHA was not linked to performance. This cross-sectional study cannot show cause.Body Composition, Eicosapentaenoic Acid, and Vitamin D are Associated with Army Combat Fitness Test Performance.
- In 46 breast cancer survivors, higher blood DHA was linked to greater change in fatigue, and higher EPA was linked to better leg strength in those who exercised. These were baseline associations, not effects of supplementation.Polyunsaturated Fatty Acids, Exercise, and Cancer-Related Fatigue in Breast Cancer Survivors.
- In 29 older adults with sarcopenia, higher blood docosahexaenoic acid was linked to more appendicular lean mass, while higher blood alpha-linolenic acid was linked to less, so the pattern was mixed.Are dietary intake and nutritional status of specific polyunsaturated fatty acids correlated with sarcopenia outcomes in…
- In 27 patients with unresectable pancreatic or bile duct cancer, skeletal muscle mass rose significantly after 4 and 8 weeks of an omega-3 enteral nutrient, though this uncontrolled study had no placebo group.Effects of ω-3 Fatty Acid Supplementation in Patients with Bile Duct or Pancreatic Cancer Undergoing Chemotherapy.
Review Totals and Summary
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Biohacker Summary
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0 of 10 biohackers on our panel recommend it
Most of the panel recommends omega-3s: six of ten lean toward recommending them and four stay neutral, and several say they use them. They take them for inflammation, heart health and triglycerides, brain function, skin, fertility, and slowing aging. Doses vary: one gram a day was cited for aging, one to three grams for fertility, two to four grams of combined EPA and DHA for triglycerides, and about two grams a day to raise a low omega-3 index. Many prefer food sources such as salmon, sardines and other oily fish, while others take fish oil capsules, and one says to take omega-3s with a fat-containing meal to absorb them better. One panelist warns that most people underdose because standard capsules hold little EPA and DHA, and another says the research on hard heart disease outcomes is not very strong.
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Dr. Eric Berg · Omega-3 Fatty Acids · recommends
- Recommends wild-caught salmon as a healthy food to eat every day, noting it contains about 2000 mg of omega-3s in just 3 ounces.
- Recommends wild salmon as it is rich in omega-3 fatty acids, which help reduce inflammation and support brain health and cognitive function, especially important as one ages.
- Recommends DHA, an omega-3 fatty acid, as a natural remedy that, along with sweet wormwood, can trigger iron into an explosion to hit cancer.
- Dr. Eric Berg mentions that sardines are packed with omega-3 fatty acids, which support brain health and metabolism.
- Mentions that wild salmon, specifically half a fillet, has 970 mg of potassium, zero carbohydrates, a good amount of magnesium, and is loaded with omega-3 fatty acids.
- Discusses what would happen if one consumed omega-3 fatty acids every day for 30 days, highlighting their benefits for brain health, heart health, and various conditions like dry eyes, dermatitis, and high blood pressure, as well as supporting calcium absorption and promoting better sleep.
- Recommends getting plenty of omega-3 fatty acids to support joint and metabolic health.
- Recommends consuming foods rich in vitamin D, including fatty fish, to boost vitamin D levels.
- Recommends fatty fish as the best type of protein for inflammation.
- Recommends fatty fish, including salmon, mackerel, and sardines, as dietary sources of vitamin D.
Siim Land · Omega-3 Fatty Acids · recommends
- Recommends taking omega-3s, including EPA and DHA, with a fat-containing meal to increase absorption.
- Increased his omega-3 intake to achieve a higher omega-3 index, which is associated with greater insulin sensitivity and better metabolic health markers.
- Increased his omega-3 index to 9.5% and notes that omega-3s have strong evidence for reducing elevated triglycerides.
- Mentions that EPA and DHA Omega-3s support heart and brain function and can lower triglycerides, with a higher omega-3 index associated with lower heart disease, Alzheimer's and mortality risk.
- Recommends Omega-3s for triglycerides and cardiovascular health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends choosing an omega-3 supplement from a brand that uses independent third-party testing and publishes a recent certificate of analysis, verifying EPA and DHA amounts, and testing for heavy metals, contaminants, and oxidation markers.
- Lists Omega-3s as one of 15 supplements backed by human studies.
- Explains that omega-3s can alter mitochondrial membranes and have broader cardiometabolic effects, making mitochondria more responsive to cellular signaling and oxidative stress from exercise, but they don't increase maximal mitochondrial respiration.
- Notes that 75% of people aren't meeting the daily recommendation for omega-3s and that Japanese people eat 2-3x more omega-3s per day than Americans or Europeans, which reflects in their higher omega-3 index.
- Thinks omega-3s have some of the strongest evidence and are worth considering.
Andrew Huberman · Omega-3 Fatty Acids · recommends
- AG1 is giving away a free bottle of omega-3 coenzyme Q10 with your first subscription.
- Mentions that AG1 is giving away a free bottle of Omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- Discusses Omega-3 Fatty Acids and EPA.
- Mentions that AG1 is offering a free bottle of Omega-3 co-enzyme Q10 with a first subscription to AG1 Pro.
- Recommends a free bottle of Omega-3 co-enzyme Q10 with the first AG1 Pro subscription.
- Mentions Omega-3s in the context of the microbiome and processed foods.
- Recommends Omega-3 co-enzyme Q10, which is offered as a free bottle with the first AG1 Pro subscription.
- States that getting 1 to 3 grams of EPA essential fatty acid per day can improve mood and cognitive function, supporting focus and concentration.
- Discusses Omega-3 Fatty Acids.
- Discusses omega-3s, artificial sweeteners, fructose, and fats.
Thomas DeLauer · Omega-3 Fatty Acids · recommends
- Recommends fish oil supplements as an omega-3 source for gut health, as they help reduce inflammatory signaling while tissue repairs.
- Recommends high-dose omega-3s, specifically 2 to four grams of combined EPA and DHA daily, to lower hepatic fat output and improve chylomicron clearance, which helps with non-fasting triglycerides.
- Recommends omega-3s, specifically 4 grams a day, to boost the muscle building response by making muscle cell membranes work better for the mTor switch to fire, and specifically mentions Pury for their clean, third-party tested omega-3s.
- Recommends consuming more omega-3s to help balance the mitochondrial membrane, as it will absorb more omega-3s instead of omega-6s.
- Recommends consuming more omega-3s to drive down inflammation.
- Recommends omega-3s, stating that a meta-analysis found 1,000 mg significantly reduced liver fat by shutting down inflammatory signals that promote fat storage, and advises looking for a triglycerol form for better absorption and to avoid oxidation.
- Recommends fatty fish like salmon and sardines, aiming for two to three servings per week, especially around a workout, because their omega-3s, particularly DHA, increase BDNF expression.
- Considers omega-3s a fundamental for brain protection, recommending both dietary sources and supplementation for EPA and DHA, as they produce pro-resolving mediators to limit inflammation.
- Recommends timing omega-3 intake around workouts because they directly help build and keep muscle by making muscle more responsive to growth signals and fighting anabolic resistance as one ages.
- Notes that Scandinavians consume fatty fish multiple times a week as part of their diet, contributing to their long lifespan and healthspan.
Dave Asprey · Omega-3 Fatty Acids · recommends
- Suggests that omega-3s may help slow aging and support cellular repair.
- Recommends omega-3s, noting that 1 gram a day slowed epigenetic aging by up to 4 months in a randomized trial of people over 70.
- Dave Asprey recommends Omega-3, citing a randomized trial showing 1g a day slowed epigenetic aging in older adults, but warns that most people underdose due to low EPA and DHA content in standard capsules.
- A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, a med, pitavastatin, and ketamine.
- Recommends getting nutrients like omega-3s from real food or Vision 101 for eyesight.
- Recommends adding omega-3 fats to improve how neurons absorb and use nutrients like vitamin C.
- States that Fatty15 supports cells better than omega-3s or fish oil, but he uses both.
- Notes that Inuit people consumed very high levels of omega-3s, specifically EPA and DHA, which contributed to their health on a whale blubber diet.
- Lists Omega-3s as a nutrient that forms the structure and different parts of the brain.
- Uses both C15 and omega-3s, noting that C15 supports cells better than omega-3s or fish oil with three times more benefits.
Dr. Rhonda Patrick · Omega-3 Fatty Acids · neutral
- Mentions that EPA is an omega-3 examined in mortality analysis and found primarily in seafood.
- States that Omega-3 fatty acids are very important for sperm health.
- Omega-3s may help slow biological aging, with added benefits when combined with vitamin D and strength training. In a 3-year randomized trial of healthy, mostly active older adults, omega-3 alone slowed several DNA-based aging clocks.
- Recommends regular intake of omega-3 rich seafood and supplementation with omega-3 fatty acids if it's appropriate for one's lifestyle, as they are beneficial for the heart by resolving inflammation and preserving membrane fluidity.
- Notes that a 100 mg per day increase in omega-3 fatty acids was associated with lowering the risk of Alzheimer's disease and cognitive decline by 10%, and that it takes about two grams a day to get to a high omega-3 index if one has a low index.
- Practical habits to help keep chronic inflammation in check include getting enough omega-3s.
- States that Omega-3s, specifically EPA and DHA, may be the most potent naturally occurring dietary compounds for reducing inflammation, and that about 2 g/day of combined EPA and DHA can raise a low omega-3 index.
- Recommends fatty fish as a source of healthy fats for muscle gain.
- Mentions that an omega-3 supplement might not be working, and one would not know without taking the Omega-3 index test.
- Recommends considering omega-3s to improve mood.
Dr. Mark Hyman · Omega-3 Fatty Acids · neutral
- Mentions omega-3 fats as existing biomarkers that play a role in mental health, which Function Health includes in their measurements.
- Mentions that omega-3s are anti-inflammatory and helpful.
- Tries to supplement with omega-3s for psoriasis and considers them the one clearly clinically effective skin nutrient for skin, hair, and nails.
- Emphasizes the importance of focusing on omega-3s, noting that a national crisis of omega-3 deficiency exists and that low omega-3 levels are a significant problem, more so than omega-6s.
- Consumes omega-3 fats through salmon at dinner.
- Notes that omega-3s are important nutrients for brain performance and aging, and that many people have gaps in these nutrients.
- Recommends omega-3 fats from wild fish, seafood, and certain nuts and seeds to fight inflammation.
- Mentions omega-3 fats as something that might be helpful for gut repair.
- Used omega-3 fats as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- States that omega-3 fats from fatty fish, flax, and walnuts help balance inflammatory pathways, but no supplement can replace daily signals from sleep, nutrition, exercise, stress management, and metabolic health.
Ben Greenfield · Omega-3 Fatty Acids · neutral
- Notes that omega-3s have solid research behind them for fertility.
- Recommends omega-3 fatty acids, specifically EPA and DHA, at 1 to 3 grams per day for better sperm morphology and motility, noting that sperm membranes are rich in polyunsaturated fatty acids.
- Recommends getting Omega-3 from oily fish such as sardines, anchovies, mackerel, herring, and salmon with skin.
- Discusses why fatty fish or fish oil may matter more than plant-based omega-3s if seed oils are in one's diet.
- Says that omega-3 fatty acids are a great way to feed the system and help with stress.
- Recommends testing for and replenishing omega-3 fatty acids if levels are low, as they can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- Recommends including EPA from fatty fish or fish oil in one's diet, especially if seed oils are present in the diet.
- Notes that B vitamins and Omega-3s work as a pair to support the brain, but not independently.
- Notes that the DO-Health study showed omega-3 had good effects, and it's a supplement people commonly take.
- Mentions that omega-3, vitamin D, and exercise all had good effects in the DO-Health study.
Peter Attia · Omega-3 Fatty Acids · neutral
- Peter and Michael explore the benefits of omega-3 fatty acids for cardiovascular trials and the challenge of delivering DHA to the brain.
- Mentions that some trials showing a benefit to PUFA were confounded by the inclusion of omega-3s, and argues that the literature on omega-3s is not super strong for decreasing hard cardiovascular disease endpoints.
- Took big doses of omega-3 postpartum to help maintain when she wasn't sitting down to eat full meals.
- Mentions consuming fatty fish, specifically sardines, as part of their diet, noting their high fat and protein content.
- Peter discusses how omega-3s from fish oil impact inflammation, heart health, and brain function, as well as the strengths and limitations of current research.
- Mentions the importance of DHA omega-3 fatty acids for neuronal membranes, which are concentrated in synapses and crucial for communication between neurons.
- Highlights the importance of DHA omega-3 fatty acids for neuronal membranes and communication between neurons, as they are concentrated in synapses.
- Discusses the mfsd2a transporter, which is specific to DHA in phospholipid form, and its role in blood-brain barrier integrity, noting that animal studies show disruption of this transporter causes significant breakdown of the blood-brain barrier and loss of omega-3 in the brain.
- States that there is a very strong clinical impression that high doses of omega-3s help with dry eye, primarily from an anti-inflammatory standpoint.
- Recommends omega-3 fatty acids, specifically DHA and EPA, for brain protection, especially for individuals with the APOE4 gene, stating that they require higher doses.
Bryan Johnson · Omega-3 Fatty Acids · recommends
- Recommends Omega 3 fatty acids as a supplement for skin health, noting they are in the Blueprint stack.
- During menopause, Bryan Johnson recommends ensuring adequate omega-3s for brain health.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
The studies given disagree: several pooled analyses and a placebo-controlled trial found small gains in muscle mass or strength while large trials found none, which supports tier 4 rather than tier 5. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 26 of the 86 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system
Possible side effects: No major side effects reported.
Supplement Facts
Omega-3 Concentrate 1200 mg
Supplement Facts
Serving Size 1 Softgel(s)
Servings Per Container 120
Amount Per Serving% Daily Value
| Calories | 10 | |
| Total Fat | 1 g | |
| Cholesterol | 10 mg | |
| Protein | 1 g | |
| Omega-3 Concentrate | 1,200 mg | † |
† Daily Value not established.
Other ingredients: Gelatin, Glycerin, Methacrylic Acid Co-Polymer, Water, Triethyl Citrate, Polysorbate 80, Glyceryl Monostearate, Propylene Glycol, Tocopherols.
Directions: 1 per day Suggested use: Adults, take 1 softgel daily with water and a meal for optimal absorption.
Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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