Nature Made Calcium 600 mg Review
Tier ⓘ
Tier 4 · Rank 8
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 8 within Tier 4 for Blood Sugar; 53 of 67 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members OnlyHuman studies
This product is a calcium supplement that the store listing says also contains vitamin D3. For the goal of blood sugar and heart health, no human studies on its ingredients were found for this review, so there is no study evidence that it helps or harms blood sugar control. The label details we have are incomplete and give no per-serving amounts for calcium or vitamin D3, so we cannot say whether either is present at a dose that has been studied for any purpose. No customer reviews were counted, and no written reviews could be read, so nothing is known about what users report. No expert or biohacker comments were available either. Until human studies tie these ingredients to better blood sugar or heart outcomes, this product cannot be ranked above the emerging level for this goal. People taking it for bone health or general nutrition should know that this review says nothing about those uses. It only covers the blood sugar goal, where the evidence we were given is empty. Anyone managing blood sugar should keep following the plan they agreed with their own doctor and not treat this as a replacement. Animal and cell studies are never counted.
Review Totals and Summary
Members OnlyWhat buyers say
No written reviews read yet.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
The main ingredient, calcium, got almost no attention from the panel: only one of the ten mentioned it, and only to list dairy and sardines as food sources, with no view on taking it as a supplement. No one gave a dose, a preferred form, a pairing or a caution for calcium, so the panel offers shoppers nothing to go on there. Vitamin D, a smaller ingredient in this product, drew far more talk, with most of the panel recommending or using it, mainly for immune health, brain health, bones and general health. Several take vitamin D3 at about 5000 IU a day, a few pair it with K2 or magnesium, and one advises taking it with dietary fat for better absorption. One panelist said there is little point in taking it unless you are deficient, and several urge testing blood levels first.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin D · warns
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
- Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
- Recommends increasing vitamin D to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- States that a lack of vitamin D can potentially cause achy bones or crashing mood.
- States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
- States that taking high doses of vitamin D3 for 14 days can improve mood, sleep, low back pain, skin issues, and blood pressure, as well as act as a natural anti-inflammatory and reduce susceptibility to sickness.
- Mentions that grass-fed liver has vitamin D.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
Dave Asprey · Vitamin D · uses
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Lists dairy and sardines as sources of Calcium.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
- Recommends taking Vitamin D in the morning or at lunch with fat.
- Notes that Boron improves vitamin D.
- Notes that Boron reduces calcium/magnesium loss.
- Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
Ben Greenfield · Vitamin D · recommends
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
- Recommends using hormone building blocks like vitamin D for hormone optimization.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Notes that vitamin D deficiency is the most common deficiency.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
Dr. Mark Hyman · Vitamin D · recommends
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
- Notes that rickets, which causes terrible bone deformities, is caused by vitamin D deficiency.
- Notes that vitamin D is an important nutrient for brain performance and aging, and that many people have gaps in these nutrients.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
Thomas DeLauer · Vitamin D · uses
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends getting vitamin D, suggesting it can be obtained while walking.
- States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
- Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
- Recommends vitamin D, especially for Hashimoto's, explaining that it drives T reg expansion to suppress autoimmune responses that attack the thyroid, and notes that vitamin D and selenium deficiencies often co-occur.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
Bryan Johnson · Vitamin D · uses
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
Dr. Rhonda Patrick · Vitamin D · neutral
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
- Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
- The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
Andrew Huberman · Vitamin D · neutral
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Adequate intake of calcium is vital for bone health.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
- Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
RAL Summary
Members OnlyTier 4 for Blood Sugar
Tier 4 fits because no human studies on this goal were found for its ingredients and there are no reviews, so the evidence is too thin to rank higher.
- Emerging: not enough evidence to rank higher yet.
- No human studies on this goal for its ingredients.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system, Endocrine system, Cardiovascular system
Possible side effects: No major side effects reported.
Supplement Facts
Vitamin D3 0 · Calcium 600 mg
Supplement Facts
Serving Size 1 Softgel(s)
Servings Per Container 100
Amount Per Serving% Daily Value
| Calories | 10 | |
| Total Fat | 1 g | |
| Vitamin D3 | 0 | |
| Calcium | 600 mg |
Other ingredients: Soybean Oil, Gelatin, Glycerin, Soy Lecithin, Water, Color added, White Beeswax.
Directions: Suggested Use: Take one softgel one to two times daily, with a meal.
Barcode (UPC) 031604025083 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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