Nature Made Collagen Peptides + C Gummies Review
Product Focus: Muscle and Strength
Tier ⓘ
Tier 4 · Rank 62
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 62 within Tier 4 for Muscle and Strength; 104 of 109 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Finding the lowest prices at the stores now. This takes a few seconds.
Products with nearly the same formula (Matched on the main ingredients)
Study, Trial or Testing Result Summary
Members Only62 human studies · 19 improved
1 of these 62 human studies gave the ingredient by drip, not by mouth.
62 human studies19 improved30 no effect78,580 people studied
The main ingredient is collagen peptides. Two gummies give 5 grams, which is at the low end of the studied range. Most clear muscle gains came at 10 to 15 grams a day. A review of 19 trials with 768 healthy adults who trained for at least 8 weeks found small gains in fat-free mass, muscle structure and maximal strength, with low to moderate certainty [1]. In 12-week training trials, 15 grams daily raised fat-free mass more than placebo in middle-aged men [2], premenopausal women [3] and older men with muscle loss, who also gained leg strength [4]. In trained men, 10 grams daily added slightly more muscle than placebo over 8 weeks [5]. In older adults who did not train, a full year of collagen did not change muscle size or strength [6]. Vitamin C is far below the studied dose here. Even at full doses, pooled trials found it neither helped nor hurt gains in lean mass or strength [7]. In some trials, high-dose vitamin C with vitamin E blunted training gains [8][9]. Each serving also has 6 grams of added sugar. Animal and cell studies are never counted.
See all 62 studies →Hide the studies
- Across 19 trials with 768 healthy adults who trained and took collagen peptides for at least 8 weeks, collagen gave small gains in fat-free mass, muscle structure, and maximal strength compared with controls, though the certainty of the evidence was low to moderate.Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous…
- Across 18 placebo-controlled trials with 322 people, vitamins C and E together before a single exercise session lowered fat oxidation damage, interleukin-6, cortisol and creatine kinase, but did not change muscle soreness or muscle strength.Effects of the combination of vitamins C and E supplementation on oxidative stress, inflammation, muscle soreness, and m…
- Across 18 placebo-controlled trials with 313 healthy people, vitamin C lowered fat oxidation damage and interleukin-6 after a single exercise session but did not change muscle damage, soreness or strength.Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-ana…
- In nine resistance training trials lasting at least 4 weeks, vitamin C and/or E neither helped nor hurt gains in lean mass or muscle strength.The effects of vitamin C and E on exercise-induced physiological adaptations: a systematic review and Meta-analysis of r…
- In a review of supplements for cancer-related muscle wasting, vitamin C improved some quality of life measures but no muscle benefit was shown, and evidence overall was not solid enough to recommend it.A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in …
- In a review of ten studies in people after knee ligament surgery, vitamin supplements showed no benefit for muscle loss, and vitamins C and E may have increased local muscle inflammation.Supplement Use in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Systematic Review.
- This broad review of nutrients for healthy aging in older adults mentions vitamin C among helpful nutrients but gives no specific muscle-building results and calls for more clinical studies.Nutraceuticals and their role in promoting musculo-skeletal healthy aging.
- In 208 healthy older adults over 1 year, 20 g of collagen protein twice daily did not change muscle size, strength, or function compared with carbohydrate.The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, a…
- In 160 older adults with knee osteoarthritis doing resistance training for 24 weeks, collagen plus chicken essence gave more fat-free mass than placebo and more grip strength than glucosamine, while collagen alone mainly reduced pain early on.Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joi…
- In 97 middle-aged untrained men doing resistance training for 12 weeks, 15 g of collagen peptides daily gave a bigger gain in fat-free mass and a bigger fat loss than placebo, though leg strength gains did not differ significantly.The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained …
- In 80 resistance-trained men taking a pre-workout blend including 500 mg vitamin C for 8 weeks, body composition and most strength measures did not differ from placebo, and early strength gains at 4 weeks were similar to placebo by 8 weeks.Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in…
- In 77 premenopausal women doing resistance training for 12 weeks, 15 g of collagen peptides daily led to greater fat-free mass, less body fat and greater hand-grip strength than placebo.Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength…
- In 66 older adults with low muscle mass, yogurt fortified with 500 mg vitamin C plus HMB and vitamin D for 12 weeks improved handgrip strength and walking speed more than plain yogurt, and also lowered inflammation and oxidative stress.A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled…
- In 64 adults with chronic lung disease doing rehabilitation, 4 weeks of 180 mg vitamin C in an antioxidant mix did not improve muscle endurance beyond placebo but raised muscle strength by 11% and cut the rate of muscle weakness from 30% to 10.7%.Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in CO…
- In 60 older women with age-related muscle loss doing resistance training, 12 weeks of 1000 mg vitamin C plus vitamin E gave larger gains in arm lean mass, muscle mass index, grip strength and knee strength than placebo.Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A …
- In 60 people with knee osteoarthritis flares, adding collagen to a joint supplement combination for 8 weeks reduced pain more and improved walking function more; muscle building was not specifically reported.[Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].
- In 57 older men and women, six months of vitamin C and E with or without resistance training changed body composition but did not change strength gains or pro-oxidant markers.Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body comp…
- In 57 young recreationally active men doing resistance training for 12 weeks, 15 g of collagen peptides daily increased fat-free mass more than placebo, but muscle fiber growth and strength gains did not differ significantly between groups.Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally A…
- In 53 older men with sarcopenia doing resistance training for 12 weeks, 15 g of collagen peptides daily increased fat-free mass and leg strength and reduced fat mass more than placebo.Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle …
- In 50 burn patients, a tube feed enriched with vitamin C and other nutrients cut infections and hospital stay, but showed only non-significant trends toward preserving muscle mass.Differential effects of three enteral dietary regimens on selected outcome variables in burn patients.
- In 50 healthy moderately active men doing resistance training for 14 weeks, 5 g of collagen peptides daily thickened the patellar tendon more than placebo, but muscle size and strength gains were similar in both groups.Specific collagen peptides increase adaptions of patellar tendon morphology following 14-weeks of high-load resistance t…
- In 50 healthy young sedentary men taking 10 g of collagen peptides daily for 16 weeks, muscle and tendon stiffness and explosive strength rose compared with placebo, but muscle size and maximal strength did not change.Collagen Peptide Supplementation Enhances Muscle-Tendon Stiffness and Explosive Strength: A 16-wk Randomized Controlled …
- In 46 adults with long COVID fatigue, taking 500 mg of liposomal vitamin C with l-arginine twice daily for 28 days improved walking distance and grip strength more than placebo.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In a randomized trial of 45 people with tennis elbow, a 30-day supplement containing 250 mg of vitamin C, collagen and hyaluronic acid, given with exercise and shock wave therapy, increased grip strength more than the other treatment groups, though vitamin C was not tested alone.Efficacy of extracorporeal shock wave therapy and nutraceutical supplementation in the treatment of lateral epicondyliti…
- In 44 people with moderate to severe chronic obstructive pulmonary disease, drinking a whey beverage fortified with vitamin C and magnesium daily for 8 weeks lowered inflammatory markers and increased lean body mass and grip strength compared with the control group.Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized c…
- In 42 young women doing strength training for 10 weeks, taking 1 g of vitamin C a day with vitamin E blunted gains in peak muscle torque and total work compared with placebo, although muscle thickness rose similarly in both groups.Effect of strength training combined with antioxidant supplementation on muscular performance.
- In 40 healthy young men doing heavy resistance training for 14 weeks, 5 g daily collagen peptides led to a bigger increase in calf muscle thickness (7.3%) than placebo (2.7%), though strength gains were the same in both groups.Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties.
- In 40 resistance-trained men over 8 weeks, 10 g of collagen daily raised muscle mass by 0.46 kg versus 0.10 kg for placebo, and collagen with whey protein gave the largest gains (2.66 kg) and strength improvements.The combined effects of whey protein and collagen supplementation on bone mineral density and muscle mass in resistance-…
- In 39 young healthy men doing leg resistance training for 15 weeks, 15 g daily collagen peptides produced greater thigh muscle volume gains than placebo (quadriceps 15.2% vs 10.3%), but strength gains did not differ.The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training.
- In 34 men aged 60 to 81 doing 12 weeks of strength training, 500 mg vitamin C plus vitamin E daily led to smaller gains in total lean mass and leg muscle thickness than placebo, though strength gains were similar in both groups.Vitamin C and E supplementation blunts increases in total lean body mass in elderly men after strength training.
- In healthy older men doing 12 weeks of strength training, taking 1000 mg vitamin C plus 235 mg vitamin E daily blunted the bone density gains seen with placebo.High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly me…
- In 31 older adults during reduced calories and inactivity, collagen peptides (60 g daily) did not protect leg lean mass, and unlike whey protein did not help muscle regrowth during recovery.A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein sy…
- In 10 older men given an extra 50 g of collagen protein daily for about 8 days, muscle protein building did not increase, unlike with whey or pea protein.The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated my…
- In 30 older men doing low-load blood flow restriction training for 8 weeks, collagen hydrolysate gave a slightly larger muscle size gain (6.7% vs 5.7%) than placebo, but the difference was not statistically significant.Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men.
- In 29 people recovering from anterior cruciate ligament surgery, 1000 mg vitamin C plus high-dose vitamin E for about 16 weeks did not change muscle strength compared with placebo.Serum cytokines and muscle strength after anterior cruciate ligament surgery are not modulated by high-doses of vitamins…
- In 26 young adults doing 10 weeks of resistance training, a multi-ingredient supplement with whey and creatine produced larger lean mass gains than 20 grams of collagen peptides taken twice daily.The Effect of a Multi-ingredient Supplement on Resistance Training-induced Adaptations.
- In 26 people doing 10 weeks of resistance training, collagen served as the control and gave smaller gains in type II muscle fiber size than a multi-ingredient whey protein supplement, with similar satellite cell responses.The Effect of Multi-Ingredient Protein versus Collagen Supplementation on Satellite Cell Properties in Males and Females…
- In 25 young men over 12 weeks of hypertrophy training, 15 g a day of collagen peptides gave larger gains in body mass, fat-free mass and strength than placebo.Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Sk…
- In 23 trained men doing resistance training for 10 weeks, taking vitamin C with vitamin E produced similar leg and bench press strength gains to placebo but appeared to blunt upper body muscle gains and grip strength improvement.Antioxidant vitamin supplementation on muscle adaptations to resistance training: A double-blind, randomized controlled …
- In 22 runners taking 1000 mg vitamin C and 300 mg vitamin E for 6 weeks before a 50-km ultramarathon, supplements did not reduce muscle damage or speed recovery of muscle strength compared with placebo.Antioxidants did not prevent muscle damage in response to an ultramarathon run.
- In 22 untrained young adults over 10 weeks of resistance training, 35 gram doses of leucine-matched collagen peptides increased muscle thickness less than whey protein, though strength and power gains were similar.Whey Protein Supplementation Is Superior to Leucine-Matched Collagen Peptides to Increase Muscle Thickness During a 10-W…
- In 20 middle-aged men on a crossover design lasting 33 days, 10 g of collagen peptides daily reduced muscle soreness and fatigue after a squat workout and left leg strength higher 48 hours later than placebo.Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-b…
- In a retrospective subgroup of 20 overweight or obese older men over 12 weeks, a collagen and safflower oil supplement gave smaller gains in lean mass and strength than a whey and casein supplement.Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrosp…
- In 20 middle-aged men doing 12 weeks of resistance training, 30 g of hydrolysed collagen increased patellar tendon size and stiffness more than placebo, but muscle thickness and strength gains were the same in both groups.Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged…
- In 17 female under-21 soccer players over 10 weeks of training, 30 g a day of collagen hydrolysate did not change knee muscle strength or muscle thickness compared with placebo, although it increased patellar tendon stiffness more than placebo.Collagen supplementation augments changes in patellar tendon properties in female soccer players.
- In 15 post-intensive care patients given 22 g of collagen peptides twice daily for 6 weeks, the trial was stopped early and no group differences in physical strength could be determined.Feasibility challenges in protein supplementation research: Insights from the convalescence of functional outcomes after…
- In 12 young adults given a single protein drink after a resistance workout, collagen hydrolysate produced far less whole-body protein retention than a dileucine amino acid blend or branched-chain amino acids, and no placebo group was included.Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated…
- In 11 professional female soccer players over 10 weeks of training, 30 g of collagen before sessions increased patellar tendon stiffness more than placebo, with no added gain in tendon size.High-intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional fema…
- In 9 older women over two 15-day diet periods, a fortified collagen protein supplement kept nitrogen balance and lean body mass unchanged, while a whey supplement lowered body weight.Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older…
- In 8 older men, a single 20 g feed of a collagen and milk protein blend built muscle protein at the same rate as milk protein alone, though the blend produced lower blood amino acid levels.A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend…
- In a case-control study of 130 adults, people with epilepsy ate less vitamin C than healthy controls and had higher body fat, but the study did not test vitamin C effects on muscle.Dietary and lifestyle behavior in adults with epilepsy needs improvement: a case-control study from northeastern Poland.
- In 10 patients with COPD, a single 2 g intravenous vitamin C infusion, compared with saline, reduced quadriceps fatigue during exercise and lowered malondialdehyde, a marker of oxidative stress.Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.
- In 39 patients with advanced cancer and wasting, a 4-month regimen including 500 mg daily vitamin C, with other antioxidants, nutrition support and drugs, led to weight gain, more lean body mass, lower inflammatory markers and better quality of life; 22 of 39 patients responded, but there was no control group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In 28 patients with advanced cancer and weight loss, a 16-week program that included 500 mg of vitamin C daily alongside several other supplements and drugs was linked to increased lean body mass and lower reactive oxygen species and inflammatory signals, but the study had no comparison group and vitamin C was not tested alone.Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment.
- In a large UK study of about 68,000 adults, higher vitamin C intake from food was linked to stronger grip in women, but this was a cross-sectional association and not a trial.Associations between diet and handgrip strength: a cross-sectional study from UK Biobank.
- In 4020 Korean adults aged 65 and older, vitamin C intake was among the top risk factors ranked by a machine learning model for sarcopenia in women, with no stated direction of effect.Sarcopenia feature selection and risk prediction using machine learning: A cross-sectional study.
- In 1420 Korean postmenopausal women, those eating the most fruit, which is rich in vitamin C and potassium, had lower odds of having multiple body composition problems, including low muscle mass, though this cross-sectional study cannot prove cause.Fruit intake and osteosarcopenic obesity in Korean postmenopausal women aged 50-64 years.
- In 584 community-dwelling older adults, vitamin C intake was higher in those with sarcopenia (low muscle), though this cross-sectional study cannot show cause and effect.Dietary intake and its association with sarcopenia in older adults: a cross-sectional analysis.
- In 498 middle-aged black South African women, a diet pattern high in vitamin C, sugar and potassium was not reported to be linked with muscle or body composition, while an animal-based diet pattern was linked with higher lean mass.Nutrient Patterns and Body Composition Parameters of Black South African Women.
- In 300 Iranian older adults, a diet pattern high in vitamin C and carbohydrates was linked with lower odds of low gait speed, but vitamin C was not separately tested for muscle mass.Patterns of Nutrient Intake in Relation to Sarcopenia and Its Components.
- In a prospective cohort of 197 older adults with type 2 diabetes followed for about 14 months, vitamin C intake was not related to loss of muscle mass.Vitamin Intake and Loss of Muscle Mass in Older People with Type 2 Diabetes: A Prospective Study of the KAMOGAWA-DM Coho…
- In a cross-sectional study of older adults in nursing homes, vitamin C intake adequacy differed by frailty status, but the study did not show that vitamin C improved muscle.Associations Between Frailty, Sarcopenia, and Nutritional Status in Older Adults Living in Nursing Homes.
Review Totals and Summary
Members OnlyWhat buyers say
No written reviews read yet.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Collagen, the main ingredient, gets a mostly positive response: of the ten panelists, three recommend it, four use it, two are neutral, and one has stopped taking it. People take it for skin, joints, connective tissue and muscle, and one takes it for his gut. Doses mentioned are 10 grams in the morning (three of them), 15 grams an hour before a workout, and 2.5 to 5 grams a day of hydrolyzed peptides for at least eight weeks for skin elasticity. Several suggest taking it with vitamin C about an hour before exercise to support joint and connective tissue. Cautions came from one panelist who said collagen alone will not repair a damaged gut wall, and another who said it is a weaker protein than whey for building muscle. Vitamin C is a smaller ingredient in this product, and the panel mostly recommends it as a partner for collagen.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Collagen · recommends
- Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
- Mentions that grass-fed liver is loaded with collagen.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
- Recommends increasing collagen intake because a lack of it can make it harder for the body to repair itself.
- Recommends consuming foods high in vitamin C to block the effects of grains.
- Discusses collagen in relation to changes in joints, skin, hair, nails, and recovery, suggesting these could be signs of needing more collagen.
- Uses one scoop of collagen in their coffee every single morning, noting that the average person needs between 10 and 15 grams minimum daily for benefits like improved joints, nails, hair, gut health, and youthful skin.
- Recommends ensuring that collagen supplements come with vitamin C.
Siim Land · Collagen · recommends
- Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Collagen as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
- 30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
- Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Mentions that glycine makes up one-third of collagen.
- Recommends taking Collagen one hour before exercise with a vitamin.
Thomas DeLauer · Collagen · uses
- Says he takes collagen to take care of his gut.
- Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
- Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
- Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Recommends taking 15 grams of collagen about 30 minutes before bed, especially on rest days, for its glycine content to aid sleep onset and for connective tissue repair.
- Recommends opting for foods rich in collagen because modern diets lack it compared to traditional nose-to-tail eating.
- Recommends 15 grams of collagen before bed, as it provides 3 grams of glycine and supports connective tissue repair, which peaks during sleep, making it a good way to get glycine for testosterone production.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
Dave Asprey · Collagen · uses
- States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
- Recommends taking collagen for better skin health.
- Recommends taking vitamin C for better skin health.
- Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
- States that currently, he is only taking vitamin C and vitamin D.
- Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
- Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
- Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
- Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
- Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
- Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
- Dave Asprey warns that collagen supplements have small, short-term effects on skin, mostly from industry-funded studies, and explains that the body breaks it down into amino acids, not directly targeting skin; he suggests taking cheaper protein if protein-deficient.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
Ben Greenfield · Collagen · recommends
- Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
- Recommends starting with collagen for body remodeling.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
- The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
- Recommends collagen for skin repair post-tattoo.
- Recommends Vitamin C for skin repair post-tattoo.
- Notes that collagen is not a complete protein, so while it can be added to things, it should not be relied upon as the sole protein source.
- Recommends collagen peptides or essential amino acids to support the dermal matrix that anchors hair follicles, considering them important for hair health.
Bryan Johnson · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Consumes collagen peptides at 4:55 am.
- Uses collagen peptides as an ingredient in Nutty Pudding.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 g of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 250 milligrams of Vitamin C.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
Dr. Mark Hyman · Collagen · neutral
- Dr. Hyman mentions collagen supplements in the context of skin aging.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- States that collagen powder may modestly improve elasticity and hydration of the skin.
- Notes that most people focus on collagen powders for skin aging, but healthy skin is built inside the body.
Andrew Huberman · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of collagen in the morning for muscle.
- Takes 10-20 grams of Collagen every day for muscle.
- Takes a multivitamin every day for longevity.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- He takes 10 grams of Collagen in the morning for skin health.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
Dr. Rhonda Patrick · Collagen · stopped
- Is no longer taking collagen.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
- Rhonda's current supplement routine includes Vitamin C.
- Dr. Rhonda Patrick, who was previously unconvinced, now recommends hydrolyzed collagen powder prophylactically for connective tissue and ligaments, especially if someone has a soft tissue injury history, to be taken 30 to 60 minutes pre-exercise with 50 milligrams of vitamin C.
- Discusses whether collagen can actually strengthen tendons.
Peter Attia · Collagen · neutral
- Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
- Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
- States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
- Recommends collagen supplements, in either pill or powder form, for hair, skin, nails, bones, and for putting on and maintaining healthy muscle, as it's difficult to get enough from diet alone.
- Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
- Asks if vitamin C matters for immune function, suggesting a need for a definitive study.
- Warns against the "total nonsense" of taking excessive amounts of vitamin C, especially in specific forms like liposomal vitamin C, for immunity, stating that it is idiotic and potentially dangerous to think it will offer immunity.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
Collagen peptides show small muscle and strength gains with training in human trials, mostly at doses above this product's 5 grams a day [1]. There are no reviews yet to confirm it, so it stays emerging.
Take 2 servings a day (6 gummies) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 30 of the 62 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system
Possible side effects: No major side effects reported. Each serving contains 6 grams of added sugar.
Supplement Facts
Includes 6 g Added Sugars 6 g · Vitamin C 60 mg · VERISOL Collagen Peptides 2.5 g
Supplement Facts
Serving Size 3 Gummies
Servings Per Container 20
Amount Per Serving% Daily Value
| Calories | 40 | |
| Total Carbohydrate | 7 g | |
| Total Sugars | 6 g | |
| Includes 6 g Added Sugars | 6 g | |
| Protein | 2 g | |
| Vitamin C | 60 mg | |
| Sodium | 30 mg | |
| VERISOL Collagen Peptides | 2.5 g | † |
† Daily Value not established.
Other ingredients: Glucose Syrup, Sugar, Water, Pectin, Sorbitol, Less than 2% of Citric Acid, Sodium Citrate, Natural Flavors, Carmine (Color), Coconut Oil, Carnauba Wax.
Directions: Adults, chew 3 gummies daily. Contents may settle over time.
Barcode (UPC) 031604006952 · Label source: Reverseagelab · Report a label change
Show entire label
More muscle and strength products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings