Nature Made Fish Oil 1200 mg Review
Product Focus: Muscle and Strength
Tier ⓘ
Tier 4 · Rank 47
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 47 within Tier 4 for Muscle and Strength; 89 of 109 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only48 human studies · 28 improved
1 of these 48 human studies gave fish oil by drip, not by mouth.
48 human studies28 improved13 no effect5,201 people studied
This product gives 2400 milligrams of fish oil a day, which is above the 2 grams used in studies. The research on fish oil for muscle is mixed. In a placebo-controlled trial of 200 older adults, 4 grams daily for 6 months increased muscle mass, grip strength and walking test performance compared with corn oil [1]. A pooled analysis of up to 66 trials found modest gains in lean mass, muscle mass and leg strength, though the studies were small and varied [2]. Other pooled analyses found no effect on lean body mass. These include 11 placebo-controlled trials [3], 26 trials in people with cancer [4], and an analysis of fish or fish oil trials that found slight fat loss but no change in lean mass [5]. In 107 older adults at risk of muscle loss, 24 weeks of protein plus fish oil did not improve lean mass, strength or performance [6]. Any benefit looks small and inconsistent. Where it appears, it is mostly in older adults and at higher doses than this product gives. Animal and cell studies are never counted.
See all 48 studies →Hide the studies
- In 26 trials of 1892 people with cancer, omega-3 fish oil raised body weight and body mass index (especially DHA plus EPA) but had no significant effect on lean body mass.Comparison of EPA and DHA&EPA on body weight, BMI, and lean body mass in cancer patients: a network meta-analysis.
- A pooled analysis of trials found fish or fish oil lowered body weight, waist size and body fat slightly, but made no difference to lean body mass or fat mass.Fish or n3-PUFA intake and body composition: a systematic review and meta-analysis.
- Across 31 publications in people with cancer taking at least 600 mg daily of omega-3 for at least 3 weeks, there was no significant difference in muscle mass, quality of life or body weight versus controls.The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patie…
- In 11 placebo-controlled trials, omega-3 supplementation had no significant effect on lean body mass in the pooled results, though two individual trials found benefits.Supplementation with omega-3 and lean body mass in the general population: A systematic review and meta-analysis.
- Pooling up to 66 trials, omega-3 supplementation modestly increased lean body mass, skeletal muscle mass and leg muscle strength, though small studies and varied results limit confidence.The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping system…
- In 8 trials, omega-3 did not change muscle protein building rates but did increase whole-body protein building rates in healthy adults and patient groups.The effects of omega-3 polyunsaturated fatty acids on muscle and whole-body protein synthesis: a systematic review and m…
- Of 18 trials in young healthy adults, 12 favored fish oil on at least one performance measure, but its role in building or keeping lean body mass is unclear.The effect of fish oil supplementation on the promotion and preservation of lean body mass, strength, and recovery from …
- In 14 trials in middle-aged and older women, six found benefits to muscle from protein, vitamin D, magnesium or fish oil and eight found none, so nutrition alone had a limited effect.Nutrition Interventions on Muscle-Related Components of Sarcopenia in Females: A Systematic Review of Randomized Control…
- In 736 pregnant women given fish oil from week 24 of pregnancy until one week after birth, their children had about 281 g more lean mass at age 6 than those whose mothers took olive oil, along with more bone and a non-significant rise in fat, with no change in lean or fat percentage.Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.
- At age 10, children of mothers given 2.4 g daily fish oil omega-3 in late pregnancy had higher BMI and more overweight, but the lean mass difference (0.49 kg) was not statistically significant.Fish oil supplementation during pregnancy, anthropometrics, and metabolic health at age ten: A randomized clinical trial…
- In 241 sarcopenic older adults over 12 weeks, a supplement combining whey protein, fish oil, and vitamin D increased appendicular muscle mass and grip strength compared with routine care, though fish oil was not tested alone.Effects of nutrition supplementation and physical exercise on muscle mass, muscle strength and fat mass among sarcopenic…
- In 200 older Chinese adults, 4 g daily fish oil for 6 months increased thigh circumference, total and limb muscle mass, hand grip strength, and Timed Up and Go performance compared with corn oil.Effects of fish oil-derived n-3 polyunsaturated fatty acid on body composition, muscle strength and physical performance…
- In 107 older adults at risk of sarcopenia, 24 weeks of leucine-enriched protein with fish-oil omega-3 did not improve lean mass, strength, physical performance or muscle protein synthesis, and knee flexion torque was lower than control.Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle…
- In 93 overweight or obese adults on a 12-week calorie-restricted diet, adding fish oil did not aid fat loss but was reported to help preserve lean body mass.A Moderate Interleukin-6 Reduction, Not a Moderate Weight Reduction, Improves the Serum Iron Status in Diet-Induced Weig…
- In 83 older adults at risk of sarcopenia, 24 weeks of leucine-enriched protein with or without long-chain omega-3 fats showed no clear added benefit for muscle mass, leg strength or walking speed, and individual responses varied little.Interindividual variability in response to protein and fish oil supplementation in older adults: a randomized controlled…
- Preterm infants fed formula with added fish-derived DHA and ARA had greater lean body mass and less fat mass at 12 months corrected age than infants on standard formula.Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, contr…
- In 60 healthy adults aged 60 to 85, 6 months of fish oil omega-3 therapy increased thigh muscle volume, handgrip strength, and one-repetition-maximum strength compared with corn oil.Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults.
- In 51 children with leukaemia aged 4 to 12, fish oil for 8 weeks increased mid-upper-arm muscle circumference more than control, along with better appetite and calorie intake.Fish oil supplementation is beneficial on caloric intake, appetite and mid upper arm muscle circumference in children wi…
- In 50 older adults doing leg resistance training for 18 weeks, 3 g per day of fish oil increased maximal leg strength more than placebo in women but not in men, and muscle quality improved more in women only.Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in ol…
- In 48 pregnant women with obesity who had outcome data, 2 grams of omega-3 daily from early pregnancy raised newborn lean mass compared with placebo wheat germ oil.Effect of Omega-3 Supplementation in Pregnant Women with Obesity on Newborn Body Composition, Growth and Length of Gesta…
- In 45 older women doing strength training, 2 grams of fish oil daily for about 13 weeks produced larger gains in muscle strength and chair-rising performance than training alone.Fish-oil supplementation enhances the effects of strength training in elderly women.
- In 38 hemodialysis patients who could not tolerate oral supplements, 3 months of fish-oil based intravenous nutrition during dialysis raised albumin and body weight compared with dietary counselling, but muscle mass and strength did not change significantly.The beneficial effects of intradialytic parenteral nutrition in hemodialysis patients with protein energy wasting: a pro…
- In 37 elderly adults with limited mobility, 12 weeks of whey protein plus omega-3 capsules and other plant compounds, combined with electrical muscle stimulation, raised knee strength by 13% more than the carbohydrate control group.Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Incre…
- In 34 sarcopenic women aged 65 and older, 4 g per day of fish oil during 14 weeks of resistance exercise increased leg muscle strength far more than sunflower oil placebo, though muscle cross-sectional area gains did not differ between groups.Randomised Controlled Trial of Fish Oil Supplementation on Responsiveness to Resistance Exercise Training in Sarcopenic …
- In 32 women starting chemotherapy for breast cancer, 4 g per day of fish oil for about 60 days increased respiratory muscle strength and endurance and distance walked in a 6-minute walk test compared with control.Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy.
- In 31 patients with heart failure, 3 months of 6.5 g per day of polyunsaturated fatty acids with alanyl-glutamine increased lean body mass and improved quality of life versus placebo, but did not improve muscle function or strength.Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chro…
- In 30 healthy young women, 3.2 g per day of fish oil for three days after an exercise bout did not speed recovery of muscle soreness or strength compared with olive oil placebo.Effects of omega-3 supplementation on muscle damage after resistance exercise in young women: a randomized placebo-contr…
- In 30 resistance-trained young men, 3 grams a day of krill oil taken around a hard resistance workout lowered muscle damage markers at 24 and 48 hours, sped recovery of leg strength and agility tests, and raised antioxidant levels compared with placebo, while inflammatory markers did not differ.Impact of Antarctic krill oil supplementation on skeletal muscle injury recovery after resistance exercise.
- In 28 healthy older adults, 12 weeks of resistance training plus fish oil increased one-rep max strength and lowered blood inflammation markers IL-6 and CRP, while the control group lost strength.Fish oil administration combined with resistance exercise training improves strength, resting metabolic rate, and inflam…
- In 27 active men, a single dose of high-EPA fish oil after muscle-damaging exercise led to better squat jump and countermovement jump recovery than placebo, while other strength and soreness measures did not differ clearly.Effect of an acute dose of omega-3 fish oil following exercise-induced muscle damage.
- In 24 healthy older women, 3 g per day of fish oil for 12 weeks increased lean mass by 4% and functional capacity by 7%, while the olive oil placebo group showed no change.Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwell…
- In 24 healthy men, 8 weeks of fish oil providing 600 mg of EPA and 260 mg of DHA daily kept muscle strength and joint range of motion higher than placebo after hard eccentric arm exercise, and reduced soreness at 3 days.Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint rang…
- In 22 patients with advanced lung cancer, 6 grams per day of fish oil plus a med for 6 weeks improved body weight and muscle strength, and these gains were larger than with fish oil plus placebo.Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on syste…
- In 22 physically active women, 6 g per day of fish oil for 21 days did not produce statistically significant differences in muscle strength or muscle damage markers compared with placebo after eccentric exercise.Effectiveness of Fish Oil Supplementation in Attenuating Exercise-Induced Muscle Damage in Women During Midfollicular an…
- In 21 young adults who completed a 10-week resistance training program, fish oil taken with training increased upper-body and relative lower-body one-rep-max strength more than placebo, with no significant difference in lean body mass.The effect of fish oil supplementation on resistance training-induced adaptations.
- In 20 young women, 5 g per day of omega-3 fats taken for about 8 weeks, including 2 weeks of leg immobilization, reduced muscle loss from disuse compared with sunflower oil.Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobili…
- In 20 resistance-trained men on a six-week weight loss diet, 4 grams a day of fish oil omega-3s did not change lean body mass compared with placebo, and strength gains were not clearly different from placebo.Influence of Fish Oil-Derived n-3 Fatty Acid Supplementation on Changes in Body Composition and Muscle Strength During S…
- In 20 older postmenopausal women, 8 weeks of resistance training plus fish oil raised handgrip strength (only the fish oil group improved) and lowered inflammatory cytokines and oxidative stress markers, while training with placebo showed no such changes.Fish Oil Supplementation with Resistance Exercise Training Enhances Physical Function and Cardiometabolic Health in Post…
- In 15 female futsal players, 1000 mg of fish oil with 30 g whey protein taken before muscle-damaging exercise improved jump height and muscle strength 48 hours later and reduced muscle soreness compared with placebo.Boosting Recovery: Omega-3 and Whey Protein Enhance Strength and Ease Muscle Soreness in Female Futsal Players.
- In 8 men with overweight or obesity, a fat preload containing fish oil four hours before protein and sugar slowed the early uptake of amino acids into muscle, with no change in insulin sensitivity.Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestio…
- In older adults taking fish oil omega-3 fats, muscle gene activity shifted toward higher mitochondrial function and lower protein breakdown, which may explain the earlier gains in muscle mass and function.Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults.
- In 40 patients with lung cancer receiving chemotherapy, 2.2 g per day of EPA from fish oil helped maintain weight and muscle mass, with about 69% of the fish oil group gaining or maintaining muscle, compared with weight and muscle loss in the standard care group.Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in p…
- In 28 older adults doing 12 weeks of resistance training, adding fish oil did not clearly improve grip strength or physical function beyond training alone, although fish oil plus training lowered blood pressure.Chronic Fish Oil Consumption with Resistance Training Improves Grip Strength, Physical Function, and Blood Pressure in C…
- In 10 healthy young adults after resistance exercise, eating salmon or an isolated mix of its amino acids and fish oil stimulated muscle protein synthesis to a similar degree.Underpinning the Food Matrix Regulation of Postexercise Myofibrillar Protein Synthesis by Comparing Salmon Ingestion Wit…
- In 30 malnourished older cancer patients over eight weeks, a fish oil-enriched protein drink improved handgrip strength, but muscle mass did not change significantly.A Prospective Interventional Study on the Beneficial Effect of Fish Oil-Enriched High-Protein Oral Nutritional Supplemen…
- In 128 gastrointestinal cancer patients on chemotherapy, fish oil-enriched nutrition over time significantly increased skeletal muscle mass and lean body mass, while the control group showed no change.Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexi…
- In colorectal cancer patients given fish oil-enriched nutrition, skeletal muscle mass improved and inflammation was reduced, especially in patients with a modified Glasgow prognostic score of 1 or 2.Clinical Burden of Modified Glasgow Prognostic Scale in Colorectal Cancer.
- In a retrospective analysis of older men with obesity, a multi-ingredient supplement containing fish oil along with whey, creatine, calcium, and vitamin D improved lean mass, leg strength, and stair-climb time more than a collagen-based supplement, though fish oil's contribution cannot be separated from the other ingredients.Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrosp…
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
The studies on fish oil for muscle disagree, with a controlled trial and one pooled analysis showing gains and other pooled analyses showing none, so the evidence is mixed rather than showing it does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 13 of the 48 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 1 g · Fish Oil 2400 mg
Supplement Facts
Serving Size 2 Softgel(s)
Servings Per Container 60
Amount Per Serving% Daily Value
| Calories | 35 | |
| Total Fat | 3 g | |
| Cholesterol | 25 mg | |
| Total Carbohydrates | 1 g | |
| Protein | 1 g | |
| Fish Oil | 2,400 mg | † |
† Daily Value not established.
Other ingredients: Gelatin, Glycerin, Water, Tocopherols.
Directions: Suggested use: Take 2 softgels daily with a meal. For easier swallowing, take with water before and during ingestion.
Barcode (UPC) 031604413286 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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