Nature Made Super B Complex Review
Nature Made Super B-Complex with C Tablets are designed to provide all eight essential B vitamins, which are Thiamin, Riboflavin, Niacin, B6, Folic Acid, Biotin, Pantothenic Acid, and B12. The product is positioned to support energy metabolism and a healthy brain and nervous system, and to help convert the food you eat into cellular energy. It also provides Vitamin C to help support the immune system. The page describes the supplement as one daily tablet with no color added, no artificial flavors, and gluten free. Nature Made describes the product as sourced from high quality ingredients. The page notes that B vitamins can be found in poultry and that Vitamin C can be found in citrus fruits. The product carries a USP Verified mark, and the page explains that USP has tested and verified the ingredients, potency and manufacturing process, and that USP sets official standards for dietary supplements. The listed serving size is one tablet, and the suggested use for adults is one tablet daily with water and a meal. The page advises that people taking meds, including anticonvulsants, or meds such as meds, should consult a healthcare professional before use because of potential drug-nutrient interactions. The page explains that B vitamins play a supportive role in the energy-producing pathways of the body and that they may be excreted more rapidly during rigorous exercise and in times of stress, which can increase the requirement. The page says the product is aimed at any adult looking to support immune health, a healthy brain and nervous system, and cellular energy production. It is not intended for people under age 18, and the page refers parents to a separate kids gummy line. The statements on the page have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure, or prevent any disease. The page also notes that the product is marked as discontinued and no longer available for purchase, and that the two-pack option is shown for subscription purchases. Customers are told to check the expiration date on the bottle.
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Study, Trial or Testing Result Summary
Members Only137 human studies · 51 improved
14 of these 137 human studies gave the ingredient by drip or injection, not by mouth.
Most of the energy support for this B complex comes from people who were low in a vitamin to begin with. Vitamin C, at a full dose when taken twice a day, improved well-being, mood and fatigue in young adults with low vitamin C [1][2], but a six year trial in adults who were not low found no change in vitality [3]. Thiamin, at a full dose, lowered fatigue in older women with a mild shortage [4], but showed no benefit for fatigue after an infection or in dialysis patients [5][6]. Riboflavin, at a full dose, eased fatigue in construction workers drinking fortified juice [7]. For niacin, a large review found related vitamin B3 compounds did not improve tiredness [8]. Vitamin B12 did not boost energy in people who were not deficient [9]. Pantothenic acid did not help exercise performance [10]. Biotin has only an uncontrolled study of a mixed product [11]. Vitamin B6 and calcium are well below the studied doses here, so their studies say little about this product [12][13]. Animal and cell studies are never counted.
See all 137 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- Across 27 studies of 1,599 adults, NAD+ precursors did not improve perceived fatigue or sleep, but nicotinamide mononucleotide improved endurance and NADH improved cognitive performance.Domain-specific effects of NAD+ precursors on fatigue and functional performance: a systematic review and network meta-a…
- In 16 studies of 616 people with multiple sclerosis and 655 healthy people, folate and B12 blood levels did not differ, suggesting they are not drivers of worse physical function; this was not a supplement trial.The Relationship of Cobalamin and/or Folate to the Patient-Centred Outcomes in Multiple Sclerosis: A Systematic Review a…
- In two placebo-controlled trials of 404 adults with Charcot-Marie-Tooth disease type 1A, ascorbic acid at two doses over 12 to 24 months had little meaningful effect on fatigue.Interventions for fatigue in peripheral neuropathy.
- Across nine studies of 720 people, three of four controlled trials found intravenous vitamin C lowered fatigue scores more than control, and four of five uncontrolled studies saw fatigue fall.Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review o…
- In 10 trials of 489 people, NADH was well tolerated and linked to better quality of life, less anxiety and lower heart rate after stress, but fatigue results were not clearly shown.Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of 37 studies in cancer patients found intravenous vitamin C may ease fatigue and other symptoms, but the evidence is preliminary and mostly uncontrolled.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of supplements for football players said vitamin C may improve performance by lowering oxidative stress, but gave no numbers and called for more research.The efficacy of dietary supplements on health status and performance of football players: a systematic review.
- A review of 14 reviews found oral niacin and nicotinamide can cause side effects including fatigue, stomach upset, flushing and liver problems, more often at higher doses and with niacin than nicotinamide.The adverse effects of oral niacin/nicotinamide - an overview of reviews.
- In a review of four diet trials in people with multiple sclerosis lasting 3 to 12 months, two diets supplying enough folate and magnesium reported improved fatigue, but firm conclusions were not possible.Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review.
- In 8112 healthy French adults, a daily antioxidant capsule containing 120 mg vitamin C for about 6 years did not change quality of life scores, including vitality, compared with placebo.Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, pla…
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 326 adults with fatigue after an infection, 4 weeks of sulbutiamine (400 or 600 mg a day) did not reduce fatigue more than placebo overall, though women on 600 mg had less fatigue at day 7 only.[Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day…
- In 311 people receiving a med agonist therapy, a daily fruit smoothie for 16 weeks did not change fatigue, fitness, or folate levels compared with standard treatment alone.Read the study on PubMed (40877839) →
- In 275 adults with early COVID-19 given a 10-day combination that included vitamin C, less fatigue at day 14 was seen only when famotidine was added, not with the vitamin C combination alone.Read the study on PubMed (41693032) →
- In 271 adults with Charcot-Marie-Tooth disease type 1A, 1.5 g of ascorbic acid daily for 2 years did not differ from placebo on neuropathy or on secondary outcomes including fatigue.Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement for 33 days improved vigour, stress and mental health ratings and made them feel less mentally tired than placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 202 hemodialysis patients, a multinutrient supplement containing vitamin C for 12 weeks did not reduce fatigue compared with placebo, though some heart rate variability measures improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 14 days improved vitality and motivation, but blood vitamin C did not explain these benefits.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit gave somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In 162 adults on a weight loss meal replacement program, folate levels improved in both groups, and energy and fatigue improved slightly more with daily calorie restriction alone than with added alternate day fasting; folate was not tested alone.Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effe…
- In 160 heart bypass surgery patients, vitamin C plus omega-3 fatty acids given from the day before surgery through the first 5 days after reduced post-operative fatigue more than placebo.The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass gra…
- In 160 heart disease patients over about 38 months, niacin plus a med caused fatigue, nausea or muscle aches in 9% versus 5% on placebo, not a significant difference.Read the study on PubMed (14759379) →
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 141 healthy office workers, a single 10 gram intravenous vitamin C dose lowered fatigue scores for up to one day compared with saline placebo, especially in those with low starting vitamin C, and also lowered oxidative stress.Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
- In 112 women with anemia after childbirth, adding 1 mg a day of folic acid to iron for 4 weeks did not change fatigue scores, hemoglobin or health status compared with iron alone.A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartu…
- In a 3-month double-blind trial of 99 people with severe kidney failure taking 250 mg vitamin C three times weekly, symptoms including fatigue were similar to placebo, and nausea trended worse with vitamin C.Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 80 elderly Irish women with marginal thiamin deficiency, 10 mg of thiamin daily for 6 weeks increased appetite and well-being and decreased fatigue compared with placebo.Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal t…
- In 80 people with advanced chronic kidney disease followed for 6 months, adding folic acid (alone or with pentoxifylline) to usual care reduced fatigue scores and improved kidney blood tests compared with usual care alone.The potential adding therapeutic effect of pentoxifylline and/or folic acid for chronic kidney disease patients: randomi…
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 58 healthy adults with mild prolonged tiredness, a supplement combining pomegranate extract with B vitamins and vitamin C reduced fatigue scores over 8 weeks compared with placebo, though vitamin C was not tested alone and biochemical markers did not change.Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monoce…
- In 58 people with long-COVID, 2000 mg of nicotinamide riboside daily raised blood NAD+ about 3-fold but did not significantly improve fatigue, cognition, or sleep versus placebo.Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled …
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 50 people recovering from COVID-19, one month of 1-methylnicotinamide improved 6-minute walk distance in 92% versus 60% without it, and severe fatigue was 20% versus 56%.Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19.
- In healthy young adults with low vitamin C levels, 500 mg twice a day for 4 weeks improved attention and work absorption compared with placebo, with a trend toward less fatigue.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In a 28-day placebo-controlled trial of 46 adults with long COVID, twice-daily liposomal vitamin C (500 mg) with l-arginine reduced persistent fatigue (2 of 23 still fatigued vs 21 of 23 on placebo) and improved walking distance and handgrip strength.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 43 adults with sleep complaints, a blend containing a small amount of vitamin B3 taken with the evening meal for 14 days shortened sleep onset time and improved next-morning mood and vigor, but had no effect on cognitive performance.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 healthy adults aged 40-76, a glycine, glutamine and niacin mixture taken for 3 weeks raised growth hormone by about 70% compared with placebo, but did not change IGF-I, mood or memory.Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and…
- In 41 trained cyclists, 4 weeks of a carnitine and alpha-lipoic acid supplement with a small amount of vitamin B1 did not improve performance or fatigue measures compared with placebo.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 40 young adults with low vitamin C, 1000 mg daily for 4 weeks improved mental vitality and reduced inflammation compared with placebo, with gut bacteria changes linked to the gains.Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitam…
- In 40 people with quiescent bowel disease and severe fatigue, 4 weeks of high-dose thiamine (600-1800 mg a day) reduced fatigue by 4.5 points versus a 0.75 point increase on placebo, with 55% and 75% of the two groups improving.Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflamm…
- In 36 volunteers, 1 g of vitamin C daily for 30 days improved maximal oxygen uptake and lowered oxidative stress only in those with the lowest vitamin C levels, and it did not reduce fatigue index.Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
- In 36 patients with primary biliary cholangitis, 4 weeks of high-dose thiamine (600-1800 mg a day) was safe but no better than placebo at reducing fatigue.High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover ran…
- In 33 soldiers during a 12-day tropical training exercise, folate status declined in all groups and those eating combat rations reported more fatigue than those eating fresh food; folate was not given as a separate supplement.The physiological and psychological effects of combat ration feeding during a 12-day training exercise in the tropics.
- In 32 healthy young adults, 28 days of a B vitamin complex including B1 increased running time to exhaustion 1.26-fold and lowered blood lactate and ammonia compared with placebo.A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation…
- In 32 Gulf War veterans with illness, a 4-6 week program of exercise, sauna and nicotinic acid plus other supplements improved physical quality of life by 6.9 points versus waitlist, and 11 of 16 quality of life, pain and fatigue measures improved.A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 28 men with marginal vitamin C status, 1000 mg daily for 8 weeks produced a physical activity rise that was not statistically significant compared with placebo, though cold episodes were fewer.Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vit…
- In 26 overweight middle-aged women doing aerobic training for 3 months, drinking 500 mL of orange juice daily was linked with lower blood lactate, suggesting less muscle fatigue than training alone.Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training.
- Eating two SunGold kiwifruit daily for 4 weeks improved mood disturbance, wellbeing and vitality compared with usual diet in 26 adults with mild to moderate mood disturbance.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 25 healthy young adults, a single dose of a pre-workout drink containing 500 mg vitamin C along with other ingredients raised self-rated energy and vigour compared with placebo, though adding synephrine gave no extra benefit.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 breast cancer survivors, 500 mg vitamin C plus vitamin E daily for 10 weeks alongside strength training did not reduce fatigue more than placebo.Effect of strength training and antioxidant supplementation on perceived and performance fatigability in breast cancer s…
- In a double-blind crossover trial of 25 resistance-trained adults, 7 days of a pre-workout drink containing 65 mg niacin (plus caffeine and other ingredients) improved some lower-body strength and endurance measures compared with placebo, but not cycling time-trial performance, with no differences in side effects.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 25 untrained men, a single 1000 mg dose of niacin before cycling raised the respiratory exchange ratio and shortened time to exhaustion compared with caffeine, suggesting impaired exercise performance.Niacin supplementation impairs exercise performance.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 21 untrained men, a caffeine supplement containing 40 mg of niacin taken once did not improve bench press strength, leg extension strength, or time to exhaustion on a bike compared with placebo.Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion durin…
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during exercise compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 18 healthy volunteers, 1000 mg a day of ascorbic acid for 8 days did not reduce physical fatigue during a long cycling task, while a different product did.Effects of Applephenon and ascorbic acid on physical fatigue.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 17 people doing hard cycling at high altitude, a 3-week broad antioxidant capsule that included vitamin C did not improve performance; a different supplement combination did better than both this capsule and placebo.Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.
- In 16 male athletes, 100 mg of thiamine daily for 3 days before cycling reduced complaints of fatigue shortly after exercise compared with placebo.Effects of thiamine supplementation on exercise-induced fatigue.
- In 15 people with chronic fatigue syndrome, injected liver extract with folic acid and vitamin B12 did not improve fatigue-related function more than placebo, and the placebo response was strong.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In 14 healthy volunteers, 3000 mg a day of ascorbic acid for 8 days did not change physical fatigue during a long cycling task compared with placebo.Daily oral administration of crocetin attenuates physical fatigue in human subjects.
- In 14 people given 1 gram a day of a thiamin derivative or placebo for 4 days in a crossover design, there were no differences in oxygen use, lactate, or 2000-meter cycling time.The effect of a thiamin derivative on exercise performance.
- In 12 middle-aged triathletes during a 90-minute cycling session, taking vitamin C with glutathione improved energy-related metabolic and heart measures and lowered an oxidative stress marker compared with placebo, though vitamin C was not tested alone and this was a single acute session.Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Perf…
- In 8 healthy young men, one week of 1.5 grams each of pantothenic acid and cysteine daily did not change muscle coenzyme A, fuel use during exercise, or work output compared with placebo.Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exerci…
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In a blood analysis of people with quiescent inflammatory bowel disease and chronic fatigue, 4 weeks of high-dose oral thiamine did not change most B vitamin levels, though those who reported less fatigue had lower riboflavin afterward.B-vitamins, related vitamers, and metabolites in patients with quiescent inflammatory bowel disease and chronic fatigue …
- In a placebo-controlled crossover pilot in healthy middle-aged adults, 7 days of RiaGev (1520 mg twice daily) raised blood NAD+ metabolites and reduced fatigue and improved concentration and motivation compared with baseline, with no clinically relevant side effects.A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In 155 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks only marginally improved mood until day 12, with effects weaker than kiwifruit, though mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 73 children and young people with mild thalassemia, 3 months of carnitine with or without 1 mg a day of folic acid reduced bone pain and muscle weakness, but the benefit was attributed to carnitine and fatigue was not reported separately.Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects.
- In 70 diabetic fatty liver patients, 1000 mg of nicotinamide daily for 12 weeks improved quality of life including the activity and fatigue scores versus no supplement, in an open-label trial.Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial.
- In 61 hemodialysis patients, 100 mg of intravenous vitamin C after each session for 6 months did not improve energy-related quality of life or red blood cell production compared with no vitamin C.Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients.
- In 14 trained male cyclists, 6 grams of pantothenic acid daily for 16 weeks did not change muscle coenzyme A levels or cycling performance compared with the control group.Chronic pantothenic acid supplementation does not affect muscle coenzyme A content or cycling performance.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- In 9 young women in a crossover study, 4 weeks of thiamine tetrahydrofurfuryl disulfide during exercise lowered blood lactate and ammonia compared with placebo and was linked to less exertion-related fatigue.The effects of endurance training and thiamine supplementation on anti-fatigue during exercise.
- In 8 people with COPD, a single 2 g IV vitamin C dose compared with saline reduced quadriceps neuromuscular fatigue and lowered inflammatory C-reactive protein during exercise, but did not improve breathlessness or exercise tolerance.Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise…
- In 7 male triathletes, 6 weeks of a daily antioxidant capsule containing 600 mg ascorbic acid did not change maximal oxygen uptake or muscle fatigue compared with placebo.No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabo…
- Construction workers who drank riboflavin-fortified apple juice daily for 28 days reported less fatigue on fatigue questionnaires, along with improved antioxidant markers.Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on …
- In 214 outpatients with COVID-19, 8000 mg ascorbic acid for 10 days did not shorten symptoms, including fatigue, compared with usual care.Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulator…
- In an open-label pilot of 50 people with Parkinson disease, 100 mg thiamine injections twice weekly were followed by improved motor and non-motor symptoms and less fatigue in six patients who had fatigue, with no placebo group to compare against.Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.
- In an open-label trial of 40 head and neck cancer survivors, 100 mg vitamin C tablets daily for 8 weeks gave less fatigue relief than Tualang honey.Effects of Tualang Honey on Cancer Related Fatigue: A Multicenter Open-label Trial of H&N Cancer Patients.
- In 39 advanced cancer patients with cachexia, a 4-month combined treatment including 500 mg daily vitamin C improved fatigue scores and lowered inflammatory markers, but the study had no placebo group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In 26 people with multiple sclerosis, 400 mg of sulbutiamine daily for about 2 months significantly reduced fatigue scores, with the clearest benefit in those also taking disease-modifying treatment, and no serious side effects; there was no control group.Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis.
- In a small uncontrolled pilot of 23 iron-deficient women, a daily food-derived supplement that also contained vitamin C was taken for 8 weeks, and self-reported energy improved, though vitamin C alone was not tested and there was no placebo group.A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Def…
- In 12 people with ulcerative colitis or Crohn's disease, high-dose oral thiamine (600 to 1500 mg daily by body weight) for 20 days led to complete fatigue relief in 10 people and nearly complete relief in 2 others, with no control group.Thiamine and fatigue in inflammatory bowel diseases: an open-label pilot study.
- In an open-label extension in inflammatory bowel disease, 300 mg per day of oral thiamine for 12 weeks did not reduce fatigue compared with no thiamine, though 66 percent of patients reached normal fatigue levels after six months of unrestricted follow-up.Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results fr…
- In a survey of complementary medicine practitioners giving IV vitamin C (average 28 g every 4 days), 59 of 9,328 patients with data had lethargy or fatigue as a side effect, and most side effects were minor.Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In 1,643 Spanish adults aged 65 and over followed for about 3.5 years, low dietary vitamin C intake was linked to a higher risk of frailty, which includes exhaustion, but this link was not statistically significant on its own.Low vitamin intake is associated with risk of frailty in older adults.
- In a 90-day follow-up of 923 Indonesian COVID-19 survivors, vitamin C combined with other micronutrients and favipiravir did not significantly change post-COVID symptoms, including fatigue, which was the most common symptom.Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: A longitudinal study.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In a survey of 576 people in Syria who had COVID-19, 76.4% reported using vitamin C, but the survey did not measure whether vitamin C improved energy or fatigue, and fatigue was the most reported symptom.COVID-19 infected patients' experiences in Syria, and the role of the pharmacists during their infection.
- Older adults with fatigue had higher blood folic acid than those without fatigue, and lower vitamin D tracked with more fatigue; this study did not test folate supplements.Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
- In 411 dentists and their wives, people who took little vitamin C reported about double the number of fatigue symptoms compared with those who took more.Daily vitamin C consumption and fatigability.
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- In a prospective study of 146 people with fatigue after COVID-19 who took Astenor Energy, a product containing arginine aspartate, vitamin B6, biotin and magnesium, fatigue scores fell over three months of treatment, but there was no placebo group and biotin's effect could not be separated from the other ingredients.The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania…
- In a retrospective German cohort of 125 breast cancer patients, adding intravenous vitamin C of 7.5 g for at least 4 weeks was associated with fewer treatment side effects, including fatigue, than no added vitamin C.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- In 101 people with relapsing multiple sclerosis, lower dietary folate intake was linked to higher fatigue scores, but this cross-sectional study cannot show cause.Dietary intake of nutrients and its correlation with fatigue in multiple sclerosis patients.
- In a retrospective chart review of 86 cancer patients given high-dose IV vitamin C (50 to 150 g per infusion), patients overall reported improved fatigue, pain, and mood, with temporary nausea and injection-site discomfort as the most common side effects.Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.
- In 67 adults with shingles, about 2 weeks of intravenous vitamin C alongside standard treatment was followed by reduced pain and less general fatigue, but the study had no placebo group.Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- Half of 60 people with chronic fatigue syndrome had low serum folate levels, but this survey did not test whether folate supplements improve energy.Serum folate and chronic fatigue syndrome.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a Swedish registry of 40 adults with a med-associated multiple acyl-CoA dehydrogenase deficiency, 38 of 39 treated with riboflavin clinically improved, including reduced fatigue and muscle symptoms.Read the study on PubMed (41808636) →
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia, those who rated themselves much improved had taken more vitamin B12 injections and higher daily folic acid for longer, though this was not a controlled test.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In 25 patients with multiple acyl-CoA dehydrogenase deficiency, those whose condition responded to riboflavin had favorable outcomes, while non-responders had more severe early illness.Determinants of Riboflavin Responsiveness in Multiple Acyl-CoA Dehydrogenase Deficiency.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- In 10 patients with late-onset multiple acyl-CoA dehydrogenase deficiency, high-dose riboflavin at 400 mg daily produced rapid muscle strength improvement, though neuropathic symptoms did not improve.Diagnostic Challenges in Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency: Clinical, Morphological, and Genetic Asp…
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
- In a large family with an inherited mitochondrial muscle mutation, riboflavin given to two affected members did not improve their exercise intolerance or fatigue.Benign mitochondrial myopathy with exercise intolerance in a large multigeneration family due to a homoplasmic m.3250T>C…
- In hypertensive patients, a nicotinamide mononucleotide supplement lowered blood pressure and improved vascular function, but energy was not measured.NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension.
- In this mostly lab and animal study, nicotinamide with pyridoxine helped muscle stem cells regenerate muscle and improved strength in animals, but energy was not measured.Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
- In mice, biotin deficiency shortened swimming time in a forced-swim test, suggesting fatigue or low mood, and a single biotin injection quickly restored swimming time; this was an animal study with no human data.Experimental study of fatigue provoked by biotin deficiency in mice.
- In exhausted rats, a daily mix of ten nutrients including a small biotin dose (0.1 mg per kg) let them run longer, reduced oxidative damage, and increased mitochondrial proteins in muscle compared with rats given no supplement; this was an animal study and biotin's effect alone was not isolated.Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats.
- In mice, pantothenate deficiency lowered tissue levels of coenzyme A and glycogen stores and shortened running time to exhaustion compared with supplemented mice.The effect of pantothenate deficiency in mice on their metabolic response to fast and exercise.
Review Totals and Summary
Members Only49,717 reviews · 93% positive
This Nature Made Super B Complex in tablet form, which carries about 49419 ratings across stores, is generally well-regarded by customers, with 88% of reviews giving it 4 or 5 stars. Customers praise its effectiveness, value, and the convenience of combining B vitamins with Vitamin C. **What it did for buyers** Many customers report positive health changes after taking these tablets. A significant number experienced an energy boost, with one reviewer stating they gained "energy to do EVERYTHING I want to do, no naps needed!" Others noticed "big changes in my overall health," including faster recovery from colds and improved healing. Some found it beneficial for "nerve health" and as a "great for the immune system." Reviewers also mentioned improved mood, digestive comfort with "no stomach upset," and even positive effects on appearance, such as hair and nails growing faster and becoming "healthy, shiny, and soft." The product is often described as "potent" and effective. **Complaints** The most common complaints revolve around the rising price and the taste. Several long-term users noted that the "Price Keeps Going Up," leading some to seek more affordable alternatives. The taste is frequently mentioned as a drawback, with descriptions like "strong vitamin taste after taking" or a "potent flavour." For some, the pill size is also a concern, with a few finding it "a little too big to swallow for me." **Taste, smell, and pill size** The tablets have a distinct sensory profile. Many describe an "Aromatic and strong vitamin flavor," which some find off-putting, while others simply note it as a characteristic without complaint, or even say it "Smells great." Regarding size, opinions are mixed. Many find the tablets to be a "reasonable size" and "NOT too big (like most others)," making them easy to swallow. However, a minority find them "too big to swallow comfortably." This summary focuses solely on the tablets, excluding feedback on other forms like gummies or gel caps. **Value for money** Many customers consider these tablets to be a good value. They are frequently described as an "affordable supplement" and offering "Great quality and value." The combination of B complex with Vitamin C is appreciated, as it "saves buying 3 products" separately. While the overall value is praised, the recurring concern about the "price keeps rising" indicates that affordability is a key factor for many buyers. **Who it suits and who it did not** This supplement appears to suit individuals seeking an energy boost, general health improvement, or support for nerve health. It is particularly favored by long-term users who trust the Nature Made brand, with some stating they "wouldn't use any other brand." Those who appreciate a daily, convenient supplement and a long supply also find it suitable. However, it may not be ideal for those sensitive to strong vitamin tastes or who struggle with larger pills. Price-conscious buyers, especially those who have observed price increases over time, might also be less satisfied.
Biohacker Summary
Members Only10 of 10 recommend it
Vitamin C is the ingredient the panel talks about most, and most of the ten recommend or use it. They take it for collagen and skin, immune support, and calming inflammation, and two pair it with collagen for joints. Doses came up rarely: one panelist takes an extra gram a day and another speaks of 2 to 4 grams, while one warns that the best dose is unclear and very high amounts might blunt the benefits of exercise. One panelist likes a liquid liposomal form, one stopped using a vitamin C serum because of its smell, and several talk about vitamin C put on the skin rather than swallowed. Only two panelists spoke about vitamin B12, one recommending a liposomal methylcobalamin form for mood and the other warning that a shortfall can cause fatigue, while folate, a smaller ingredient in this product, drew a preference for methylfolate over folic acid.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin B12 · neutral
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- States that one can of sardines contains 382 mg of calcium.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Notes that irritability, overthinking, and nightmares can point to low vitamin B1, which is depleted by refined grains and sugar.
- Explains that vitamin B1 is needed to support the autonomic nervous system and metabolize glucose.
- States that cracked corners on the mouth are often a B2 vitamin issue, which is also behind cracked heels and chapped lips.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Suggests that increasing vitamin B1 may help address the underlying problem of bruxism.
- States that vitamin B6 is needed to absorb magnesium.
- Warns against calcium carbonate, calling it limestone and the worst source of calcium, stating it takes 12 steps to be converted in the body and is like eating rocks.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
Thomas DeLauer · Vitamin C · recommends
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
Dave Asprey · Vitamin C · neutral
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
- Recommends taking vitamin C for better skin health.
- States that folate can affect how the body responds to a supplement.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Recommends methylfolate as a better option than folic acid.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
Ben Greenfield · Vitamin C · recommends
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends methylfolate as an active form of folate that the body can use directly without conversion.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Recommends introducing methylfolate into the diet to address high homocysteine levels.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists dairy and sardines as sources of Calcium.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
Dr. Mark Hyman · Vitamin C · recommends
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
- Notes that some people may need a little bit extra folate with a supplement.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
Dr. Rhonda Patrick · Vitamin C · neutral
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Mentions folate as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Notes additional gaps in calcium.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
Andrew Huberman · Vitamin C · uses
- Takes a multivitamin every day for longevity.
- Mentions biotin.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
- Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Mentions that Riboflavin (Vitamin B2) hits cytochrome 2 in the mitochondrial electron transport chain, contributing to energy production.
- Recommends taking methyl folate as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
Peter Attia · Vitamin C · stopped
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- Takes 250 milligrams of Vitamin C.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
- Recommends calcium at 1,200 mg daily for women during the follicular phase, depending on dietary intake.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
RAL Summary
Members OnlyTier 3 for Energy
Tier 3 rests on nearly fifty thousand reviews, 93 percent positive, with some study support; the stronger support comes not from the biotin animal studies but from human trials where full dose vitamin C and thiamin lowered fatigue in people who were low in them [1][4].
Where the evidence disagrees: 68 of the 137 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Metabolic system, Immune system, Muscular system
Combine with: To further enhance energy production and overall vitality, consider combining a Super B Complex with Magnesium, which is essential for ATP synthesis and works synergistically with B vitamins in numerous enzymatic reactions. Coenzyme Q10 (CoQ10) is another excellent addition, as it plays a critical role in the electron transport chain within mitochondria, directly supporting cellular energy. For comprehensive support, Omega-3 fatty acids can help reduce inflammation and support cellular health, indirectly contributing to sustained energy levels.
Possible side effects: No major side effects reported in the studies at these doses; reviewers mention a strong vitamin taste and some find the tablet large to swallow.
Supplement Facts
Vitamin C 150 mg · Thiamin 100 mg · Riboflavin 20 mg
| Vitamin C (as Ascorbic Acid) | 150 mg | 167% |
| Thiamin (as Thiamine Mononitrate) | 100 mg | 8333% |
| Riboflavin | 20 mg | 1538% |
| Niacin (as Niacinamide) | 25 mg | 156% |
| Vitamin B6 (as Pyridoxine Hydrochloride) | 2 mg | 118% |
| Folate | 665 mcg DFE (400 mcg Folic Acid) | 167% |
| Vitamin B12 (as Cyanocobalamin) | 15 mcg | 625% |
| Biotin | 30 mcg | 100% |
| Pantothenic Acid (as d-Calcium Pantothenate) | 5.5 mg | 110% |
| Calcium (as Dibasic Calcium Phosphate) | 35 mg | 3% |
Other ingredients: Cellulose Gel, Hypromellose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Polyethylene Glycol.
Directions: Adults, take 1 tablet daily with water and a meal.
Label source: Naturemade · Report a label change
Sizes and barcodes: 140 Tablet(s), UPC 0 31604 02727 8 (on market); 360 Tablet(s), UPC 0 31604 02729 2 (off market); 160 Tablet(s), UPC 0 31604 04065 9 (off market); 390 Tablet(s), UPC 0 31604 03029 2 (off market); 30 Tablet(s), UPC 0 31604 02976 0 (off market); 175 Tablet(s), UPC 0 31604 02934 0 (off market); 60 Tablet(s), UPC 0 31604 02734 6 (off market); 460 Tablet(s), UPC 0 31604 02728 5 (off market)
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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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