Nature Made Super B Complex Review

Nature Made Super B-Complex with C Tablets are designed to provide all eight essential B vitamins, which are Thiamin, Riboflavin, Niacin, B6, Folic Acid, Biotin, Pantothenic Acid, and B12. The product is positioned to support energy metabolism and a healthy brain and nervous system, and to help convert the food you eat into cellular energy. It also provides Vitamin C to help support the immune system. The page describes the supplement as one daily tablet with no color added, no artificial flavors, and gluten free. Nature Made describes the product as sourced from high quality ingredients. The page notes that B vitamins can be found in poultry and that Vitamin C can be found in citrus fruits. The product carries a USP Verified mark, and the page explains that USP has tested and verified the ingredients, potency and manufacturing process, and that USP sets official standards for dietary supplements. The listed serving size is one tablet, and the suggested use for adults is one tablet daily with water and a meal. The page advises that people taking meds, including anticonvulsants, or meds such as meds, should consult a healthcare professional before use because of potential drug-nutrient interactions. The page explains that B vitamins play a supportive role in the energy-producing pathways of the body and that they may be excreted more rapidly during rigorous exercise and in times of stress, which can increase the requirement. The page says the product is aimed at any adult looking to support immune health, a healthy brain and nervous system, and cellular energy production. It is not intended for people under age 18, and the page refers parents to a separate kids gummy line. The statements on the page have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure, or prevent any disease. The page also notes that the product is marked as discontinued and no longer available for purchase, and that the two-pack option is shown for subscription purchases. Customers are told to check the expiration date on the bottle.

Product Focus: EnergyAlso covers:BrainMetabolismImmune systemMusclesRanked among:Vitamin B complex
Tier ⓘ
Tier 3 · Rank 2
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 2 within Tier 3 for Energy; 34 of 132 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
75 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
93% of 49,717
Biohacker Mentions
10 of 10
Cost per month
$2

Study, Trial or Testing Result Summary

Members Only137 human studies · 51 improved

14 of these 137 human studies gave the ingredient by drip or injection, not by mouth.

137 human studies51 improved68 no effect62,233 people studied

Most of the energy support for this B complex comes from people who were low in a vitamin to begin with. Vitamin C, at a full dose when taken twice a day, improved well-being, mood and fatigue in young adults with low vitamin C [1][2], but a six year trial in adults who were not low found no change in vitality [3]. Thiamin, at a full dose, lowered fatigue in older women with a mild shortage [4], but showed no benefit for fatigue after an infection or in dialysis patients [5][6]. Riboflavin, at a full dose, eased fatigue in construction workers drinking fortified juice [7]. For niacin, a large review found related vitamin B3 compounds did not improve tiredness [8]. Vitamin B12 did not boost energy in people who were not deficient [9]. Pantothenic acid did not help exercise performance [10]. Biotin has only an uncontrolled study of a mixed product [11]. Vitamin B6 and calcium are well below the studied doses here, so their studies say little about this product [12][13]. Animal and cell studies are never counted.

See all 137 studies →Hide the studies

Review Totals and Summary

Members Only49,717 reviews · 93% positive
49,717 reviews · Amazon 44,813 · Walmart 4,143 · Walgreens 298 · Sam's Club 273 · CVS 139
93% positive3% neutral4% negative

This Nature Made Super B Complex in tablet form, which carries about 49419 ratings across stores, is generally well-regarded by customers, with 88% of reviews giving it 4 or 5 stars. Customers praise its effectiveness, value, and the convenience of combining B vitamins with Vitamin C. **What it did for buyers** Many customers report positive health changes after taking these tablets. A significant number experienced an energy boost, with one reviewer stating they gained "energy to do EVERYTHING I want to do, no naps needed!" Others noticed "big changes in my overall health," including faster recovery from colds and improved healing. Some found it beneficial for "nerve health" and as a "great for the immune system." Reviewers also mentioned improved mood, digestive comfort with "no stomach upset," and even positive effects on appearance, such as hair and nails growing faster and becoming "healthy, shiny, and soft." The product is often described as "potent" and effective. **Complaints** The most common complaints revolve around the rising price and the taste. Several long-term users noted that the "Price Keeps Going Up," leading some to seek more affordable alternatives. The taste is frequently mentioned as a drawback, with descriptions like "strong vitamin taste after taking" or a "potent flavour." For some, the pill size is also a concern, with a few finding it "a little too big to swallow for me." **Taste, smell, and pill size** The tablets have a distinct sensory profile. Many describe an "Aromatic and strong vitamin flavor," which some find off-putting, while others simply note it as a characteristic without complaint, or even say it "Smells great." Regarding size, opinions are mixed. Many find the tablets to be a "reasonable size" and "NOT too big (like most others)," making them easy to swallow. However, a minority find them "too big to swallow comfortably." This summary focuses solely on the tablets, excluding feedback on other forms like gummies or gel caps. **Value for money** Many customers consider these tablets to be a good value. They are frequently described as an "affordable supplement" and offering "Great quality and value." The combination of B complex with Vitamin C is appreciated, as it "saves buying 3 products" separately. While the overall value is praised, the recurring concern about the "price keeps rising" indicates that affordability is a key factor for many buyers. **Who it suits and who it did not** This supplement appears to suit individuals seeking an energy boost, general health improvement, or support for nerve health. It is particularly favored by long-term users who trust the Nature Made brand, with some stating they "wouldn't use any other brand." Those who appreciate a daily, convenient supplement and a long supply also find it suitable. However, it may not be ideal for those sensitive to strong vitamin tastes or who struggle with larger pills. Price-conscious buyers, especially those who have observed price increases over time, might also be less satisfied.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Vitamin C is the ingredient the panel talks about most, and most of the ten recommend or use it. They take it for collagen and skin, immune support, and calming inflammation, and two pair it with collagen for joints. Doses came up rarely: one panelist takes an extra gram a day and another speaks of 2 to 4 grams, while one warns that the best dose is unclear and very high amounts might blunt the benefits of exercise. One panelist likes a liquid liposomal form, one stopped using a vitamin C serum because of its smell, and several talk about vitamin C put on the skin rather than swallowed. Only two panelists spoke about vitamin B12, one recommending a liposomal methylcobalamin form for mood and the other warning that a shortfall can cause fatigue, while folate, a smaller ingredient in this product, drew a preference for methylfolate over folic acid.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin B12 · neutral
    • 8 Nov 2026 · neutral · Facebook ↗
      Mentions that one can of sardines provides 348% of the daily Vitamin B12.
    • 8 Nov 2026 · Calcium · neutral · Facebook ↗
      States that one can of sardines contains 382 mg of calcium.
    • 7 Nov 2026 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Vitamin C · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
    • 7 Nov 2026 · Calcium · warns · Facebook ↗
      Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
    • 6 Nov 2026 · Vitamin C · neutral · Instagram ↗
      Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
    • 6 Nov 2026 · Vitamin B1 · neutral · Instagram ↗
      Notes that irritability, overthinking, and nightmares can point to low vitamin B1, which is depleted by refined grains and sugar.
    • 6 Nov 2026 · Vitamin B1 · warns · YouTube ↗
      Explains that vitamin B1 is needed to support the autonomic nervous system and metabolize glucose.
    • 6 Nov 2026 · Vitamin B2 · neutral · Instagram ↗
      States that cracked corners on the mouth are often a B2 vitamin issue, which is also behind cracked heels and chapped lips.
    • 6 Nov 2026 · Calcium · recommends · Podcast ↗
      Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
    • 5 Nov 2026 · Vitamin B1 · recommends · Podcast ↗
      Suggests that increasing vitamin B1 may help address the underlying problem of bruxism.
    • 1 Nov 2026 · Vitamin B6 · neutral · YouTube ↗
      States that vitamin B6 is needed to absorb magnesium.
    • 31 Oct 2026 · Calcium · warns · YouTube ↗
      Warns against calcium carbonate, calling it limestone and the worst source of calcium, stating it takes 12 steps to be converted in the body and is like eating rocks.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
  • Thomas DeLauer · Vitamin C · recommends
    • 6 Nov 2026 · recommends · YouTube ↗
      Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
    • 18 Sep 2026 · Calcium · neutral · Facebook ↗
      Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 29 Aug 2026 · neutral · Instagram ↗
      States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
    • 25 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
    • 19 Aug 2026 · recommends · YouTube ↗
      Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
    • 12 Aug 2026 · Calcium · recommends · YouTube ↗
      Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
    • 8 Aug 2026 · neutral · YouTube ↗
      Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
  • Dave Asprey · Vitamin C · neutral
    • 3 Nov 2026 · neutral · YouTube ↗
      Recounts a doctor telling him in his 20s that vitamin C would kill him.
    • 3 Nov 2026 · Biotin · warns · YouTube ↗
      Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
    • 24 Oct 2026 · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Folate · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 14 Aug 2026 · neutral · Podcast ↗
      Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
    • 5 Aug 2026 · Folate · recommends · Facebook ↗
      Recommends methylfolate as a better option than folic acid.
    • 25 Jul 2026 · neutral · Facebook ↗
      Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 16 Jul 2026 · warns · YouTube ↗
      Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
    • 14 Jul 2026 · recommends · YouTube ↗
      Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
    • 9 Jul 2026 · warns · YouTube ↗
      Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
    • 1 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
    • 16 Jun 2026 · Calcium · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
  • Ben Greenfield · Vitamin C · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 12 Oct 2026 · Folate · recommends · Facebook ↗
      Recommends methylfolate as an active form of folate that the body can use directly without conversion.
    • 24 Sep 2026 · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 25 Aug 2026 · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends Vitamin C for skin repair post-tattoo.
    • 9 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 9 Jul 2026 · Folate · recommends · YouTube ↗
      Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
    • 9 May 2026 · Calcium · neutral · YouTube ↗
      Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
    • 6 May 2026 · Calcium · neutral · X ↗
      Mentions calcium as a common deficiency.
    • 25 Apr 2026 · Niacin · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 18 Apr 2026 · Folate · recommends · YouTube ↗
      Recommends introducing methylfolate into the diet to address high homocysteine levels.
    • 18 Apr 2026 · Niacin · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
  • Siim Land · Vitamin C · recommends
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 14 Oct 2026 · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 30 Sep 2026 · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 14 Aug 2026 · Calcium · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 27 Jul 2026 · neutral · X ↗
      Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
    • 27 Jul 2026 · neutral · X ↗
      States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
    • 27 Jul 2026 · recommends · YouTube ↗
      States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
    • 9 Jul 2026 · neutral · YouTube ↗
      Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
    • 4 Jul 2026 · uses · YouTube ↗
      Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
    • 24 Apr 2026 · Vitamin B12 · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
    • 24 Mar 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
  • Dr. Mark Hyman · Vitamin C · recommends
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 21 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 6 Oct 2026 · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
    • 30 Sep 2026 · neutral · YouTube ↗
      Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
    • 30 Sep 2026 · Niacin · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 14 Sep 2026 · recommends · Facebook ↗
      Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
    • 9 Sep 2026 · uses · YouTube ↗
      Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
    • 31 Aug 2026 · Vitamin B6 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 31 Aug 2026 · Folate · uses · YouTube ↗
      Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
    • 20 Aug 2026 · Calcium · recommends · YouTube ↗
      Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
  • Dr. Rhonda Patrick · Vitamin C · neutral
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 1 Nov 2026 · Folate · neutral · YouTube ↗
      Mentions folate as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
    • 28 Sep 2026 · Folate · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 5 Jun 2026 · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
    • 4 May 2026 · uses · YouTube ↗
      Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
    • 5 Feb 2026 · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · neutral · Facebook ↗
      Notes that ~35% of Americans are low in vitamin C.
    • 9 Jan 2026 · Calcium · neutral · Facebook ↗
      Notes additional gaps in calcium.
    • 29 Dec 2025 · recommends · X ↗
      Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
    • 8 Oct 2025 · Vitamin B12 · warns · Facebook ↗
      Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
    • 9 Sep 2025 · warns · YouTube ↗
      Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
    • 9 Sep 2025 · Biotin · warns · YouTube ↗
      Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
    • 4 Sep 2025 · neutral · Facebook ↗
      Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
  • Andrew Huberman · Vitamin C · uses
    • 17 Jun 2026 · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 13 Apr 2026 · Biotin · neutral · Podcast ↗
      Mentions biotin.
    • 2 Feb 2026 · recommends · YouTube ↗
      Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
    • 15 Dec 2025 · Vitamin B12 · neutral · YouTube ↗
      States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
    • 7 Jul 2025 · uses · YouTube ↗
      Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
    • 16 Jun 2025 · uses · YouTube ↗
      Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
    • 28 Apr 2025 · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
    • 31 Mar 2025 · Folate · recommends · YouTube ↗
      States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
    • 3 Feb 2025 · uses · YouTube ↗
      Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
    • 18 Nov 2024 · uses · YouTube ↗
      Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
    • 14 Oct 2024 · recommends · YouTube ↗
      Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
    • 7 Oct 2024 · Vitamin B12 · recommends · YouTube ↗
      Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
    • 7 Oct 2024 · Vitamin B2 · neutral · YouTube ↗
      Mentions that Riboflavin (Vitamin B2) hits cytochrome 2 in the mitochondrial electron transport chain, contributing to energy production.
    • 7 Oct 2024 · Folate · recommends · YouTube ↗
      Recommends taking methyl folate as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
  • Peter Attia · Vitamin C · stopped
    • 3 Jul 2025 · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 29 Jun 2025 · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 11 May 2025 · Biotin · warns · YouTube ↗
      Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
    • 22 Oct 2024 · Calcium · recommends · YouTube ↗
      Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
    • 21 Oct 2024 · Calcium · recommends · YouTube ↗
      Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
    • 9 Sep 2024 · Vitamin B12 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 6 Sep 2024 · neutral · YouTube ↗
      States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
    • 19 Aug 2024 · recommends · YouTube ↗
      Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
    • 19 Aug 2024 · Folate · recommends · YouTube ↗
      Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
    • 26 Feb 2024 · Biotin · warns · YouTube ↗
      Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
    • 24 Oct 2023 · Folate · uses · YouTube ↗
      Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
  • Bryan Johnson · Vitamin B12 · uses
    • 5 Jun 2025 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
    • 5 Jun 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 12 May 2025 · Calcium · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
    • 3 Feb 2025 · Vitamin C · neutral · YouTube ↗
      Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
    • 8 Jan 2025 · Vitamin C · uses · YouTube ↗
      Applies vitamin C after showering.
    • 5 Sep 2024 · Biotin · neutral · YouTube ↗
      Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
    • 26 Sep 2023 · Vitamin C · uses · YouTube ↗
      Takes 250 milligrams of Vitamin C.
    • Date not recorded · Vitamin C · recommends · Website ↗
      Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
    • Date not recorded · Vitamin C · uses · Website ↗
      Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
    • Date not recorded · Vitamin C · uses · Website ↗
      He uses Vitamin C, typically in a serum, in the morning for skin health.
    • Date not recorded · Calcium · recommends · Website ↗
      Recommends calcium at 1,200 mg daily for women during the follicular phase, depending on dietary intake.
    • Date not recorded · Calcium · recommends · Website ↗
      Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
    • Date not recorded · Calcium · uses · Website ↗
      Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
    • Date not recorded · Biotin · recommends · Website ↗
      Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.

RAL Summary

Members OnlyTier 3 for Energy

Tier 3 rests on nearly fifty thousand reviews, 93 percent positive, with some study support; the stronger support comes not from the biotin animal studies but from human trials where full dose vitamin C and thiamin lowered fatigue in people who were low in them [1][4].

Where the evidence disagrees: 68 of the 137 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Metabolic system, Immune system, Muscular system

Combine with: To further enhance energy production and overall vitality, consider combining a Super B Complex with Magnesium, which is essential for ATP synthesis and works synergistically with B vitamins in numerous enzymatic reactions. Coenzyme Q10 (CoQ10) is another excellent addition, as it plays a critical role in the electron transport chain within mitochondria, directly supporting cellular energy. For comprehensive support, Omega-3 fatty acids can help reduce inflammation and support cellular health, indirectly contributing to sustained energy levels.

Possible side effects: No major side effects reported in the studies at these doses; reviewers mention a strong vitamin taste and some find the tablet large to swallow.

Supplement Facts

Vitamin C 150 mg · Thiamin 100 mg · Riboflavin 20 mg
Supplement Facts
Serving Size 1 Tablet
Amount Per Serving% Daily Value
Vitamin C (as Ascorbic Acid)150 mg167%
Thiamin (as Thiamine Mononitrate)100 mg8333%
Riboflavin20 mg1538%
Niacin (as Niacinamide)25 mg156%
Vitamin B6 (as Pyridoxine Hydrochloride)2 mg118%
Folate665 mcg DFE (400 mcg Folic Acid)167%
Vitamin B12 (as Cyanocobalamin)15 mcg625%
Biotin30 mcg100%
Pantothenic Acid (as d-Calcium Pantothenate)5.5 mg110%
Calcium (as Dibasic Calcium Phosphate)35 mg3%

Other ingredients: Cellulose Gel, Hypromellose, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate, Polyethylene Glycol.

Directions: Adults, take 1 tablet daily with water and a meal.

Label source: Naturemade · Report a label change

Sizes and barcodes: 140 Tablet(s), UPC 0 31604 02727 8 (on market); 360 Tablet(s), UPC 0 31604 02729 2 (off market); 160 Tablet(s), UPC 0 31604 04065 9 (off market); 390 Tablet(s), UPC 0 31604 03029 2 (off market); 30 Tablet(s), UPC 0 31604 02976 0 (off market); 175 Tablet(s), UPC 0 31604 02934 0 (off market); 60 Tablet(s), UPC 0 31604 02734 6 (off market); 460 Tablet(s), UPC 0 31604 02728 5 (off market)

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The Nature Made Super B Complex label
Super B Complex

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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.