Nature Made Zero Sugar‡ EnergyWell Drink Mix Review

Vitamin C is the main studied ingredient at a full dose when taken as two servings a day, and its evidence is small and mixed. In 31 people with an underactive thyroid, 500 mg with their medicine lowered thyroid stimulating hormone ^[1], and a very small 12-person trial also found benefit ^[2]. A larger trial of 102 people with autoimmune thyroid disease found no difference from placebo ^[3]. Vitamin D is also at a full dose. Pooled trials in Hashimoto's disease found lower thyroid antibodies ^[4], but another pooled analysis found vitamin D alone did not lower antibodies ^[5], and it did not help Graves' disease remission ^[6]. Several ingredients are below the studied dose. Vitamin A is only a trace amount compared with studied doses ^[7]. Zinc ^[8] and selenium ^[9] are both below the doses that helped. The potassium studies tested potassium iodide or bromide, not plain potassium, so they do not apply to this drink ^[10]. Vitamin E ^[11], vitamin B6 ^[12], caffeine ^[13] and taurine ^[14] showed no thyroid benefit in human studies. Animal and cell studies are never counted.

This drink mix has no single main ingredient in the panel's statements, so the group view rests on the smaller ingredients in this product, with vitamin D and caffeine drawing the most comment. Vitamin D got the most attention: most of the panel recommend or use it, citing general health, immune support, brain health, and healing, with doses mentioned from 5000 IU up to 10,000 IU daily, and one panelist advising taking it with dietary fat for better absorption. Caffeine was used by several for mood, vigor, and jet lag, while others suggested pairing it with L-theanine, stopping it earlier for sleep, or warned that it will not fix brain fog on its own, and one panelist came off it for a year. Zinc was recommended by a few for prostate, gut, and healing support, vitamin C was recommended for collagen and skin, and potassium was used by one for workouts while another preferred getting it from food rather than supplements.