Nature's Bounty Co Q-10 100 mg Review

Nature's Bounty Co Q-10 100 mg, 75 Softgels is presented as an antioxidant that supports heart health and is essential for cellular energy production. The page states that it may be especially important for people taking a med medications to take a Co Q-10 supplement, because meds can reduce Co Q-10 levels in the body. The page adds a note that Coenzyme Q-10 is not intended to serve as a replacement for a med therapy, and that a person should not discontinue taking any prescribed medications while supplementing with Coenzyme Q-10. Each serving is one softgel containing 100 mg of Q-Sorb Coenzyme Q-10, and the Daily Value is listed as not established. The container holds 75 servings. The directions say that for adults, one softgel should be taken two times daily, preferably with meals. The product is highlighted with the benefits Supports Cardiovascular Health, Clinically Studied Ingredient, and Q-Sorb. The other ingredients are Rice Bran Oil, Gelatin, and Vegetable Glycerin, and the product contains less than 2 percent of Soy Lecithin and Titanium Dioxide Color. The label is described as Non-GMO and free of artificial flavor, artificial sweetener, sugar, starch, milk, lactose, gluten, wheat, yeast, and fish, and it is sodium free. The warning advises pregnant or nursing people, anyone taking medications, or anyone with a medical condition to consult a doctor before use, to discontinue use and consult a doctor if any adverse reactions occur, and to keep the product out of reach of children. The page instructs that the bottle be stored at room temperature and not used if the seal under the cap is broken or missing. The product is manufactured by Nature's Bounty, Inc. in Bohemia, NY 11716, U.S.A. The FAQ section explains that people should follow the directions on the label, and that anyone wishing to take more than the recommended amount should consult a doctor or other healthcare professional. The page also lists related Co Q-10 options in other strengths, including 400 mg in 39 softgels and 200 mg in 45 softgels, as well as a Fish Oil product. The brand notes that it has offered its products since 1971 and that its products are tested every month.

Product Focus: Blood PressureAlso covers:HeartMetabolism
Tier ⓘ
Tier 3 · Rank 7
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 7 within Tier 3 for Blood Pressure; 16 of 34 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
69 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
93% of 575
Biohacker Mentions
7 of 10
Cost per month
$102

Study, Trial or Testing Result Summary

Members Only72 human studies · 43 improved
72 human studies43 improved22 no effect12,037 people studied

Each softgel gives 100 milligrams of coenzyme Q10, a full dose that matches the amounts that worked in studies. The largest review of the evidence pooled 26 randomized trials in 1,831 people with heart and metabolic conditions. It found coenzyme Q10 lowered the top blood pressure number by about 4.8 points, with the most benefit at about 100 to 200 milligrams a day [1]. An earlier pooled analysis of 17 trials in 684 people found the top number fell but the bottom number did not change [2]. In a 24-week trial of 101 people with abnormal blood fats, 120 milligrams a day lowered both numbers more than a dummy pill [3]. In a 12-week trial of 83 people whose top number alone was high, 60 milligrams twice a day lowered it by about 18 points [4]. Not every study agrees. A pooled analysis of seven trials in 356 people with diabetes found no change in blood pressure [5]. Two small trials in 50 people with high blood pressure also found no clear change [6]. Overall, the evidence leans toward a modest drop in the top number, mostly in people with heart or metabolic conditions. Animal and cell studies are never counted.

See all 72 studies →Hide the studies

Review Totals and Summary

Members Only575 reviews · 93% positive
575 reviews · Walmart 388 · Walgreens 126 · CVS 45 · Naturesbounty 16
93% positive0% neutral7% negative

Buyers are largely happy with Nature's Bounty Co Q-10 100 mg softgels, which carry about 575 ratings across the stores that sell them. Most written feedback is positive, with a few clear complaints. This summary covers the softgels only. **What buyers say it did for them:** Many describe steadier energy and better stamina, and some mention workouts. One says, "more steady energy during the day and better recovery after workouts." Others take it for heart reassurance: "It gives me peace of mind about my heart." One calls it "A must for cholesterol management." The Walgreens page adds that people taking meds speak well of it. One reviewer says it stopped their a med-related muscle pain, and another says their doctor recommended it to prevent pain from meds. **What they complain about:** Complaints are few but notable. One reviewer had trouble after taking it: "severe cramps and diarrhea" about an hour after one softgel with food, and they won't buy it again. Another said they never received the supplement. On the Walgreens page, one buyer was surprised to find another supplement included in the product and might return it, while admitting they should have read the information more closely. Another was disappointed they could not buy it in a store and had to order it. **Taste, smell, size and form:** This is a strong point. Reviewers describe small, smooth softgels that are easy to swallow: "Tiny pill thats easy to swallow." Several note no unpleasant aftertaste: "don't have any weird aftertaste." One says there is "no harsh smell when you open" the bottle, and another says it "dissolves easily." The Walgreens summary also notes the softgels are small and easy to swallow. **Value for money:** Price comes up often. One reviewer says, "a good price for an expensive supplement," and another calls it "a great value for the size." On the Walgreens page, value was the most common theme, with several people calling it a good deal given how costly CoQ10 is. One says the 100 mg strength is hard to find from other brands, which keeps them loyal. Reviewers also praised delivery and freshness on that page. **Who it suits and who it didn't:** It seems to suit older adults and people who want a daily heart or energy supplement. One reviewer says, "A must have for us aging folks," and a 72-year-old says they feel really good. People on meds, and those whose doctors recommended CoQ10, also report good experiences. Several say they always rebuy it, and some say they trust the brand's purity and consistency. One buyer wishes they had bought the 200 mg strength instead, though they think 100 mg is probably fine for others. It did not suit the reviewer who had stomach cramps and diarrhea, who also prefers clear vegetarian capsules to softgels so the product's color can be seen. Anyone who checks labels closely should read the ingredient information first, given the buyer surprised by an added supplement.

Biohacker Summary

Members Only7 of 10 recommend it
7 of 10 biohackers on our panel recommend it

Eight of the ten panelists spoke about coenzyme Q10, and the group leans positive: four of them say they take it or recommend it, mainly to support the mitochondria, which make the body's energy, and to help with fatigue, heart health and oxidative stress. Doses named range from 100 to 400 mg a day, with 300 mg a day mentioned twice and one panelist suggesting up to 1200 mg for some people, and one advises taking it with a fatty meal, ideally dinner. Three of them point to the ubiquinol form or to forms that absorb better, and one says standard versions are poorly absorbed. Several say meds can lower the body's coenzyme Q10, which is a reason a few take it, though one says good data is lacking that it prevents muscle symptoms from meds, and another says there is no real evidence it extends lifespan. One panelist tried it as part of an energy program and appears to have stopped, and it is also paired with omega-3 and with PQQ by others.

See all 9 biohackers →Hide the biohackers
  • Dr. Eric Berg · Coenzyme Q10 · neutral
    • 18 Oct 2026 · neutral · YouTube ↗
      Mentions that grass-fed liver has coenzyme Q10.
    • 2 Oct 2026 · recommends · YouTube ↗
      Recommends that anyone with a med prescription should also take coenzyme Q10, specifically the ubiquinol form, to support heart and muscle function.
    • 10 Sep 2026 · neutral · Facebook ↗
      Notes that Merck filed a patent for a med combined with coenzyme Q10, but never added it back into the formula, and that major heart organizations do not recommend taking coenzyme Q10 alongside meds.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends taking coenzyme Q10, specifically ubiquinol, to prevent the side effects of meds, especially for those experiencing muscle weakness, pain, fatigue, or exercise intolerance. He suggests a dose of 200 to 400 mg, or even up to 1200 mg a day for some individuals.
    • 18 Jun 2026 · neutral · YouTube ↗
      Mentions that coenzyme Q10 supports the heart and mitochondria as a powerful antioxidant, and meds deplete its production.
    • 3 Jun 2026 · recommends · YouTube ↗
      States that coenzyme Q10 has been known to help people with fibromyalgia feel better.
    • 30 May 2026 · recommends · YouTube ↗
      Recommends Coenzyme Q10, especially for those on meds, as it's a key nutrient for energy in the mitochondria and works with vitamin E and selenium, and suggests taking it at lunch with a meal.
    • 27 Apr 2026 · recommends · YouTube ↗
      Recommends coenzyme Q10 as a remedy for long COVID.
    • 18 Feb 2026 · neutral · YouTube ↗
      Mentions that meds block coenzyme Q10 and refers to another video where he discusses it.
    • 28 Nov 2025 · recommends · YouTube ↗
      Dr. Berg highlights coenzyme Q10 as a key essential nutrient for mitochondria in the heart, and recommends taking it if on meds, as meds deplete this nutrient.
  • Dave Asprey · Coenzyme Q10 · uses
    • 1 Sep 2026 · uses · YouTube ↗
      States he takes 300 mg of Coenzyme Q10 every day for 20 years because it is necessary for mitochondria to function and is important for longevity, noting that meds lower it.
    • 16 May 2026 · recommends · YouTube ↗
      Recommends coenzyme Q10 (CoQ10) to support mitochondria, as it helps generate energy and fights oxidative stress.
    • 6 Feb 2025 · neutral · YouTube ↗
      Mentions that there are methylation genes for Coenzyme Q10 that convert it to ubiquinol.
    • 14 Dec 2024 · recommends · YouTube ↗
      Suggests taking Coenzyme Q10 to optimize mitochondria.
    • 29 Sep 2024 · neutral · YouTube ↗
      Mentions Coenzyme Q10 as something that can change blood viscosity, alongside sunlight and earthing.
    • 2 May 2024 · recommends · YouTube ↗
      Includes Coenzyme Q10 as a helpful addition to a med protocol.
    • 31 Aug 2023 · uses · YouTube ↗
      Used to give his dog coenzyme Q10 for mitochondrial function.
    • 5 May 2023 · neutral · YouTube ↗
      Dave Asprey mentions Coenzyme Q10 as something one might take to boost ATP production.
    • 6 May 2022 · uses · YouTube ↗
      Dave Asprey mentions that Coenzyme Q10 is a big deal for a lot of people regarding energy.
    • 25 Sep 2020 · neutral · YouTube ↗
      Mentions Coenzyme Q10 as one of the micronutrients that can help protect the glycocalyx.
  • Andrew Huberman · Coenzyme Q10 · uses
    • 6 Jul 2026 · uses · YouTube ↗
      Personally takes Omega-3 and Coenzyme Q10 every day, noting they are known to support cardiovascular health, cellular health and energy, and brain health.
    • 8 Jun 2026 · uses · YouTube ↗
      Personally takes coenzyme Q10 every day, noting it supports cardiovascular health, cellular health, energy, and brain health.
    • 23 Jun 2025 · neutral · YouTube ↗
      Discusses a study where probiotics, magnesium orotate, and coenzyme Q10 showed a short-term improvement in symptoms of major depression.
    • 23 Jan 2023 · neutral · Podcast ↗
      Discusses Coenzyme Q10 as a fertility supplement.
    • 23 Jan 2023 · recommends · YouTube ↗
      Recommends Coenzyme Q10 at 100 to 400 milligrams per day, taken with a meal containing fat, ideally dinner, to improve sperm quality by supporting mitochondrial health, which is vital for sperm formation and fertilization.
    • 9 Jan 2023 · recommends · YouTube ↗
      States that coenzyme Q10 should be taken with food.
    • Date not recorded · neutral · Website ↗
      Mentions Coenzyme Q10 as a tool for fertility.
    • Date not recorded · uses · Website ↗
      Andrew Huberman says he personally takes AG1's new Omega-3 Coenzyme Q10 product every day, noting that Omega-3 and Coenzyme Q10 are known to support cardiovascular health, cellular health, energy, and brain health.
    • Date not recorded · neutral · Website ↗
      Andrew Huberman notes that some papers suggest coenzyme Q10 might be beneficial for egg quality.
  • Thomas DeLauer · Coenzyme Q10 · uses
    • 30 Jun 2026 · uses · YouTube ↗
      States that coenzyme Q10 is one of his favorite compounds for the mitochondria, and it is found in sardines.
    • 29 Jun 2026 · recommends · YouTube ↗
      Recommends getting coenzyme Q10 from good quality red meat and organ meat, or through supplementation, to act as an electron catcher in the mitochondria, optimizing energy production and reducing oxidative stress.
    • 16 Jun 2026 · recommends · YouTube ↗
      Recommends utilizing coenzyme Q10 to support mitochondrial function and the electron transport chain, making hydration more effective.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends coenzyme Q10 as a runner-up for energy and mitochondrial function, explaining it's an electron carrier in the mitochondrial chain that focuses on the last complex, creating a bigger net to catch electrons and reduce oxidative stress.
    • 30 May 2026 · recommends · YouTube ↗
      Recommends Coenzyme Q10 for fatigue, stating it's essential for electron transport, ATP regeneration, and reducing oxidative stress, and can be found in organ meats, fatty fish, pistachios, and sesame seeds.
    • 12 Jul 2025 · neutral · YouTube ↗
      Mentions Coenzyme Q10 as a micronutrient essential for the complex biological workings of metabolism in the mitochondria.
    • 1 Nov 2023 · recommends · YouTube ↗
      Recommends 300-600mg of Coenzyme Q10 for those intermittent fasting or on low carb, to help utilize fuel better, support heart health, and strengthen mitochondrial function by improving the proton gradient.
    • 3 Apr 2023 · recommends · YouTube ↗
      Recommends Coenzyme Q10 for people who are fasting or on a ketogenic diet, explaining that it helps fuel the electron transport chain, leading to more efficient energy processing and increased energy during OMAD and the eating period.
    • 11 Feb 2023 · recommends · YouTube ↗
      Recommends 300 to 600 milligrams of Coenzyme Q10 during the eating period to help the electron transport chain and utilize food for energy.
    • 31 Jan 2023 · recommends · YouTube ↗
      Notes that Coenzyme Q10 is good for mitochondrial health and energy, and there's growing evidence linking it to nitric oxide production, suggesting a supplement if one doesn't get enough from meat.
  • Dr. Mark Hyman · Coenzyme Q10 · recommends
    • 4 May 2026 · recommends · YouTube ↗
      Mentions that coenzyme Q10 is important in mitochondrial function and can be a factor in migraines.
    • 30 Jul 2025 · stopped · YouTube ↗
      Tried coenzyme Q10 as part of a meticulous effort to address energy and metabolism issues, but implies they no longer use it as they were looking for an easier solution.
    • 19 Jun 2024 · uses · YouTube ↗
      Included coenzyme Q10 in a mitochondrial rejuvenation program to support mitochondrial function.
    • 31 May 2023 · neutral · YouTube ↗
      States that mitochondria need coenzyme Q10 and that PQQ has been shown to work very well with it.
    • 12 Apr 2023 · recommends · YouTube ↗
      States that coenzyme Q10 can be very helpful if fatigue is a significant problem, and is a mitochondrial support for energy recovery.
    • 2 Dec 2022 · recommends · YouTube ↗
      Recommends Coenzyme Q10 for better mitochondrial function, lower inflammation, improved insulin sensitivity, and blood sugar, especially for those taking meds or experiencing age-related decline in CoQ10 production.
    • 9 Jul 2022 · uses · YouTube ↗
      Takes Coenzyme Q10, believing it affects the mitochondria and the aging process, even without full scientific confirmation.
    • 25 May 2022 · uses · YouTube ↗
      Mentions that coenzyme Q10 was part of the mitochondrial therapy that helped a child with autism improve, and later states it is a key component of mitochondrial supplementation.
    • 1 Apr 2022 · recommends · YouTube ↗
      Recommends coenzyme Q10 for mitochondrial repair, stating that high doses of 200 to 400 milligrams a day are needed, spread out with food.
    • 16 Mar 2022 · recommends · YouTube ↗
      Recommends Coenzyme Q10 for mitochondrial function, especially for fatigue and heart problems, at doses of 200 to 400 milligrams a day, spread out as 100 milligrams three or four times a day with food, noting its safety and effectiveness for conditions like migraine headaches.
  • Ben Greenfield · Coenzyme Q10 · neutral
    • 16 Dec 2025 · neutral · Instagram ↗
      Discusses Coenzyme Q10 as an ingredient that MitoQ uses in a mitochondria-directed form, noting that standard CoQ10 rarely achieves movement past the cell membrane and into mitochondria.
    • 20 Nov 2025 · neutral · Facebook ↗
      Discusses Coenzyme Q10 (CoQ10) in the context of MitoQ Pure being an upgraded form of it.
    • 11 Apr 2024 · stopped · YouTube ↗
      Is currently using CoQ10 because any type of a med, including natural ones like red yeast rice extract, can deplete the body's coenzyme Q10 levels, affecting mitochondrial health.
    • 14 Sep 2023 · recommends · YouTube ↗
      Is a big proponent of crystal-free coenzyme Q10, explaining that most CoQ10 products have poor absorption due to crystallization, and recommends Pharma Nord's patented process for keeping CoQ10 in solution, which achieves three to ten times higher plasma levels.
    • 10 Aug 2023 · recommends · YouTube ↗
      Recommends coenzyme Q10 for lung repair, highlighting its importance for mitochondrial and cardiopulmonary function, especially for those exposed to pollution or who have smoked.
    • 4 Aug 2023 · uses · YouTube ↗
      Takes coenzyme Q10 in the morning for heart disease.
    • 24 Jun 2023 · uses · YouTube ↗
      Is currently using CoQ10 because meds, whether prescription or natural like red yeast rice extract, can strip the body of coenzyme Q10 levels.
    • 6 Oct 2022 · recommends · Podcast ↗
      Suggests it is smart to include Coenzyme Q10 for reducing fatigue, referencing a systematic review and meta-analysis.
    • 25 Jul 2019 · warns · YouTube ↗
      Believes Coenzyme Q10 is probably beneficial for 80-year-olds with cardiac issues, but not great for most people, as they are not deficient in it when aging starts around 30-35.
    • 6 Jun 2019 · recommends · YouTube ↗
      Recommends a stack of Coenzyme Q10, MitoQ, and PQQ for mitochondrial support, noting that supplements stacking all three are available on Amazon.
  • Siim Land · Coenzyme Q10 · neutral
    • 12 Jun 2023 · neutral · YouTube ↗
      Describes Coenzyme Q10 as a mitochondrial supportive supplement that may increase energy production, but notes there isn't actual lifespan or longevity evidence for it.
    • 22 Sep 2021 · uses · YouTube ↗
      Takes 300 milligrams of Coenzyme Q10 daily as a supplement, noting it helps with energy production, fat oxidization, heart health, and longevity.
  • Peter Attia · Coenzyme Q10 · neutral
    • 7 Nov 2022 · neutral · YouTube ↗
      Notes there isn't good data that Coenzyme Q10 prevents a med Associated muscle symptoms, but doesn't object if patients want to take it because it makes them feel better about taking a med.
  • Dr. Rhonda Patrick · Coenzyme Q10 · neutral
    • Date not recorded · neutral · Website ↗
      A daily dose of coenzyme Q10 reduces blood pressure by about 4mmHg systolic and 3mmHg diastolic in people with type 2 diabetes, potentially lowering cardiovascular risk.

RAL Summary

Members OnlyTier 3 for Blood Pressure

Tier 3 fits: 93% of 575 reviews are positive, and pooled human trials show a modest drop in the top blood pressure number [1][2], though some trials found no effect [5][6].

Where the evidence disagrees: 22 of the 72 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system, Metabolic system

Combine with: For heart support, CoQ10 pairs well with magnesium (glycinate or taurate) for blood pressure and rhythm, omega-3 fish oil (EPA/DHA) for triglycerides and vascular health, and L-carnitine for mitochondrial fatty-acid transport. Take CoQ10 with a fat-containing meal to improve absorption of this fat-soluble compound. If you take a med, CoQ10 may help offset depletion. If aging and DNA repair remain your goal, consider adding an NAD+ precursor (NMN or nicotinamide riboside), PQQ for mitochondrial biogenesis, resveratrol or pterostilbene for sirtuin support, and vitamin D3/K2 and a B-complex (folate, B12) for DNA methylation and repair. Consult a healthcare provider first, especially if you take meds like a med or meds, as CoQ10 can interact with them.

Possible side effects: No major side effects were reported in the studies given. The review summary mentions one buyer who had severe cramps and diarrhea after a softgel.

Supplement Facts

Q-Sorb Coenzyme Q-10 100 mg
Supplement Facts
Serving Size 1 Softgel(s)
Amount Per Serving% Daily Value
Q-Sorb Coenzyme Q-10100 mg†
† Daily Value not established.

Other ingredients: Rice Bran Oil, Gelatin, Vegetable Glycerin, Contains <2% of.

Directions: Directions: For adults, take one (1) softgel two times daily, preferably with meals.

Barcode (UPC) 074312048869 · Label source: NIH label database · Report a label change

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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.