NDS Nutrition Pump Fuel® ALL IN Medium Stim Review
NDS Nutrition Pump Fuel ALL IN Medium Stim is a pre-workout supplement powder. It is sold in a container holding 20 servings, and one serving is 1 scoop (48 g). Per serving the label lists 170 calories, 15 g total carbohydrate and 1 g total sugars. It also lists vitamin B6 at 3 mg, vitamin B12 at 30 mcg, choline at 200 mg, calcium at 70 mg, magnesium at 80 mg and potassium at 100 mg. The main item is the PUMP FUEL ALL IN Blend, printed at 45330 mg per serving. Other ingredients are natural and artificial flavor, calcium silicate, sucralose, potassium bicarbonate, cherry extract for color, acesulfame potassium, beet vegetable juice color, spirulina extract for color and dicalcium phosphate. The directions printed on the label say to mix 1 scoop with 20 fl. oz. of cold water, adjusting to desired taste, and to consume it 30 minutes before a workout. The label adds that it is best taken on an empty stomach, that use is limited to 1 scoop in a 24-hour period, and that it is to be used as part of a physical conditioning program.
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Study, Trial or Testing Result Summary
Members Only72 human studies · 24 improved
5 of these 72 human studies gave the ingredient by injection, not by mouth.
Magnesium is the only ingredient here at the dose that worked in studies. In 30 adults with metabolic conditions, 80 mg of magnesium a day for 4 weeks reduced fatigue compared with placebo [1]. Magnesium also improved energy and fatigue scores in 64 women with polycystic ovary syndrome [2]. Other trials, mostly in people with fibromyalgia, found no fatigue benefit [3][4]. Choline is present at 200 mg. Two small trials of choline alone found it did not delay fatigue during exercise [5][6]. Vitamin B6 and calcium are well below the doses studied. Vitamin B6 helped tiredness at 50 mg a day in women with premenstrual symptoms [7]. Calcium helped at 1000 mg a day [8]. Larger trials of B vitamins found no benefit for quality of life or fatigue [9][10]. Vitamin B12 did not boost energy in people who were not deficient [11]. Potassium has no supplement study of its own [12]. Most of each serving is a large proprietary blend. Its ingredients and their amounts are not given, so it could not be judged and has no studies. Animal and cell studies are never counted.
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- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- A review of 26 trials in 3,273 people with chronic fatigue syndrome found most supplements did not help, but magnesium and NADH showed benefit, though the trials were small and at high risk of bias.Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of four diet trials in people with multiple sclerosis found that two diets providing enough folate and magnesium reduced fatigue, but firm conclusions were not possible.Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review.
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 697 adults with mild high blood pressure, a low-sodium, high-potassium diet with placebo for 6 months was linked to more fatigue (34%) than the usual diet (18%) or a weight loss diet (15%).Effect of antihypertensives on sexual function and quality of life: the TAIM Study.
- In 204 adults with fatty liver disease, a Chinese herbal recipe eased fatigue more than a phosphatidylcholine capsule over 3 months, but this study tested phosphatidylcholine only as the comparison drug, so it says nothing about choline improving energy.[Treatment of nonalcoholic steatohepatitis by Jianpi Shugan Recipe: a multi-center, randomized, controlled clinical tria…
- In 202 dialysis patients given a multinutrient supplement including B6 for 12 weeks, fatigue and quality of life did not differ from placebo, though some heart rate variability measures and a herpes virus level improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 110 people with fibromyalgia, 3 months of a supplement with coenzyme Q10, tryptophan and magnesium did not significantly reduce fatigue (placebo improved significantly), though pain, sleep and overall impact improved.Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomiz…
- In 98 adults with inflammatory bowel disease in remission, 4 weeks of magnesium plus B vitamins reduced fatigue more than placebo, and also lowered ulcerative colitis symptom scores but not Crohn's disease scores.Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 86 people with mental fatigue, a single dose of homeopathic potassium phosphate taken before an attention test did not work better than placebo, though the test's ceiling effect limits the result.Homeopathy for mental fatigue: lessons from a randomized, triple blind, placebo-controlled cross-over clinical trial.
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 64 women with polycystic ovary syndrome, 10 weeks of magnesium improved the energy and fatigue score and total quality of life compared with placebo.The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 49 patients after colon surgery, magnesium oxide (1 g every 12 hours) did not change fatigue or bowel recovery compared with placebo.Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 32 people with chronic fatigue syndrome, weekly magnesium sulphate injections for 6 weeks led 12 of 15 treated patients to report benefit and better energy, versus 3 of 17 on placebo.Red blood cell magnesium and chronic fatigue syndrome.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 30 adults with hypertension, diabetes or high blood fats, drinking water with 80 mg of magnesium daily for 4 weeks improved body mass index, insulin, triglycerides and fatigue compared with placebo water.Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
- In 25 healthy recreationally active adults, a single dose of a pre-workout supplement containing vitamin B12 as methylcobalamin, along with caffeine, raised self-reported vigor and energy compared with a placebo drink, though exercise performance did not change.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 resistance-trained people, a week of a pre-workout drink containing 45 mcg B12 and other ingredients helped maintain some strength and lifting measures versus placebo but did not change cycling time trial performance.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 22 college-aged adults taking 350 mg of magnesium daily for 10 days, muscle soreness and perceived recovery improved compared with placebo, but performance gains did not reach statistical significance.Effects of Magnesium Supplementation on Muscle Soreness and Performance.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 20 trained male cyclists, a single 2.43 g dose of choline bitartrate raised blood choline but did not delay fatigue or change work performed in brief or prolonged cycling compared with placebo.Effect of choline supplementation on fatigue in trained cyclists.
- In 20 junior cyclists, a daily multi-nutrient tablet containing magnesium for 4 weeks led to faster fatigue recovery than a plain vitamin product, but magnesium was not tested alone.Studies concerning the ergogenic value of Cantamega-2000 supply in top junior cyclists.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 16 trained men with two nights of short sleep, zinc magnesium aspartate had no effect on sleep, ratings of fatigue or morning weightlifting performance compared with placebo.Effects of Supplementing Zinc Magnesium Aspartate on Sleep Quality and Submaximal Weightlifting Performance, following T…
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In 14 male college football players, a single dose of a choline-based multi-ingredient supplement taken 60 minutes before testing led to higher rate of torque development and impulse during fatiguing leg contractions than placebo, though baseline strength and jump height did not differ.Choline-Based Multi-Ingredient Supplementation Can Improve Explosive Strength during a Fatiguing Task.
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In eight men, a glucose drink lowered blood potassium during and after intense cycling, but it did not delay fatigue compared with placebo.A single oral glucose load decreases arterial plasma [K+ ] during exercise and recovery.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In 7 well-trained runners, drinking a prescribed volume of a potassium-containing carbohydrate-electrolyte drink during 4 hours of recovery from a long run let them keep running about 16% longer later than drinking as much as they wanted.Influence of fluid intake pattern on short-term recovery from prolonged, submaximal running and subsequent exercise capa…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In people with fibromyalgia, 100 mg of magnesium daily for one month did not change fatigue more than placebo.Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinica…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 92 patients with high blood pressure, magnesium at 320 mg a day reduced some complaints such as nervousness and sleep problems but had no effect on mental or physical fatigue.[Level of total and ionized magnesium fraction based on biochemical analysis of blood and hair and effect of supplemente…
- In 14 conditioned volunteers doing 4 hours of heavy-load treadmill walking, 8.425 g of choline citrate raised blood choline but did not improve run time to exhaustion, squat performance or perceived exertion compared with placebo.The effects of choline supplementation on physical performance.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- Eight healthy young men taking 6 grams of potassium-magnesium aspartate over 24 hours before a hard cycling test lasted about as long to exhaustion as those given placebo, so no endurance benefit was seen.The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise …
- In breast cancer patients taking 400 mg of magnesium oxide daily for 4 weeks, fatigue was significantly reduced, though this single-group pilot study had no placebo comparison.A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients.
- In a large cohort of about 81,500 women aged 60 and older followed for a median of 16 years, higher magnesium intake was linked to a lower risk of frailty, with the top fifth of intake showing 12% lower risk than the bottom fifth.Total magnesium intake and risk of frailty in older women.
- In a drug surveillance study of 2817 mostly older adults with brain circulation problems, taking about 6 ml a day of oral citicoline for 15 days to 2 months was followed by reduced dizziness, headache, insomnia, and memory complaints, with fatigue also among the improved symptoms; 5% reported side effects, mostly digestive.Efficacy and safety of oral CDP-choline. Drug surveillance study in 2817 cases.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In a 3.5-year study of 1,643 adults aged 65 and older, those with the lowest dietary vitamin B6 intake had about 2.8 times the odds of developing frailty, which includes exhaustion, compared with those with the highest intake. This is an association from diet, not proof that supplements prevent frailty.Low vitamin intake is associated with risk of frailty in older adults.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- Red blood cell magnesium was normal in 89 people with chronic fatigue syndrome, and a magnesium loading test in 6 of them found no deficiency, so the authors saw no reason to use magnesium treatment for this condition.Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- In a clinical observation of 60 spandex factory workers exposed to a industrial solvent, a combination of Chinese medicines that included polyene phosphatidylcholine was linked to lower liver enzymes and bilirubin and to recovery of most abnormal blood ammonia levels. The abstract does not report an energy or fatigue outcome after treatment.Dimethylacetamide-induced toxic hepatitis in spandex workers: clinical presentation and treatment outcomes.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
Review Totals and Summary
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Biohacker Summary
Members Only10 of 10 recommend it
Most of the panel recommends magnesium, and several more say they use it, with only one staying neutral. Sleep is the top reason: many take it at night, and forms named include glycinate, which is praised for absorbing well, and threonate, with two panelists taking 400 mg before bed and others suggesting it for deep sleep. Other reasons given are blood pressure, muscle recovery and cramps, energy, vitamin D function, bone health and keeping potassium in the body longer. Daily amounts mentioned run from 300 to 400 mg up to 400 to 600 mg, and one panelist aims for about a gram from supplements; some also get it from electrolyte drinks, and one noted that magnesium does not fix waking up during the night. Potassium, choline, calcium and vitamin B12 are smaller ingredients in this product, and potassium was mostly mentioned as something that works alongside magnesium in electrolyte drinks.
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Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
- States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
- Notes additional gaps in calcium.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- States that one can of sardines contains 382 mg of calcium.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Recommends potassium as an important electrolyte, noting that most people get less than half of the 4700 mg RDA.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends ensuring adequate choline intake, as a deficiency can make one susceptible to liver fat, and it's important for preventing fat accumulation in the liver.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Recommends choline-rich foods to enhance focus and acetylcholine.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- States that potassium plays a critical role in nerve signaling and muscle contraction, especially in the heart, and low levels can lead to dangerous irregular heart rhythms.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Explains that potassium helps open a gate, allowing creatine to slip through and cross the blood-brain barrier more effectively.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave explains how to stack racetams with choline for smarter cognitive enhancement.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists potatoes and fruit as sources of Potassium.
- Lists dairy and sardines as sources of Calcium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
- Notes that bananas have potassium but there are at least 8 other foods with more potassium than bananas.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
RAL Summary
Members OnlyTier 4 for Energy
Magnesium at a full studied dose has some human trial support for less fatigue, though the results are mixed [1]. With only 10 reviews, the evidence stays emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 41 of the 72 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Musculoskeletal system, Metabolic system
Combine with: For Energy, the B vitamins in this product are often paired with iron, because iron carries oxygen that cells use when turning food into fuel. They are also often paired with CoQ10, which works in the same energy-making steps inside cells. Magnesium is already on the label, but ATP-linked energy work is often paired with creatine, since creatine helps recycle the cell's stored energy and the body uses it up during hard effort.
Possible side effects: No major side effects reported. In one choline study, about 5 percent reported side effects, mostly digestive.
Supplement Facts
Vitamin B6 3 mg · Vitamin B12 30 mcg · Choline 200 mg
| Calories | 170 | |
| Total Carbohydrate | 15 g | |
| Total Sugars | 1 g | |
| Vitamin B6 | 3 mg | |
| Vitamin B12 | 30 mcg | |
| Choline | 200 mg | |
| Calcium | 70 mg | |
| Magnesium | 80 mg | |
| Potassium | 100 mg | |
| PUMP FUEL® ALL IN Blend | 45,330 mg | † |
Other ingredients: Natural & Artificial Flavor, Calcium Silicate, Sucralose, Potassium Bicarbonate, Cherry Extract (Color), Acesulfame Potassium, Vegetable Juice Color (Beet), Spirulina Extract (Color), Dicalcium Phosphate.
Directions: Mix 1 scoop with 20 fl. oz. of cold water (adjust to desired taste) and consume 30 minutes prior to workout. For best results take on an empty stomach. Limit use to no more than 1 serving (1 scoop) in a 24-hour period. To be used as part of a physical conditioning program.
Label source: Reverseagelab · Report a label change
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Our articles on this subject
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
- Magnesium Glycinate vs Threonate: Which Form Is Right for You?Article · Nov 6, 2026
Graded November 15, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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