NuMedica NuFemina Review
NuFemina™ is a synergistic blend of ingredients designed to help support premenstrual health and wellbeing. This formula helps support healthy estrogen metabolism in women. The product is listed under the Female Health category on the NuMedica formulas page, under the product code NM315. Each serving is three capsules, taken once per day or as directed by a healthcare practitioner. Each container holds 90 vegetable capsules with a serving size of 3 capsules and 30 servings per container. Each three-capsule serving contains calcium 120 mg, calcium D-glucarate 1,000 mg, chasteberry (Vitex sp.) extract 225 mg, diindolylmethane (DIM) 200 mg, and indole-3-carbinol (I3C) 150 mg. The other ingredients are hydroxypropyl methylcellulose used for the vegetable capsule, microcrystalline cellulose, magnesium stearate, and silicon dioxide. The product is free of milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soy. The page carries a caution that pregnant or nursing women should consult their healthcare practitioner before use, and that the product should be kept out of reach of children. Storage guidance says to keep the product tightly closed in a cool, dry place. Pricing is not shown publicly; the page directs visitors to sign in to see pricing. A product sheet image and a link to download the technical focus document are also provided for NM315. No customer reviews, star ratings, or review counts are displayed on this page, so no review statistics can be reported from it. The page is a practitioner-facing formula page from NuMedica, and the details above are the only product information the page provides.
Product Focus: Hormone Balance for WomenAlso covers:Sexual health
Tier ⓘ
Tier 3 · Rank 9
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 9 within Tier 3 for Hormone Balance for Women; 36 of 61 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
71 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 52
Biohacker Mentions
10 of 10
Cost per month
$80 at 2 servings
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Study, Trial or Testing Result Summary
Members Only52 human studies · 43 improved
52 human studies43 improved5 no effect8,492 people studied
Chaste berry is the best-studied ingredient here, at a full dose. A pooled analysis of three placebo-controlled trials in 520 women found those taking it were 2.57 times more likely to have premenstrual symptoms go away [1]. In one trial, 52% improved on chaste berry versus 24% on placebo [2]. Daily doses of 40 mg and 20 mg each cut premenstrual symptoms more than placebo [3][4]. It also eased cyclic breast pain [5]. A review warned that study flaws likely overstate the benefit [6]. Diindolylmethane, also at a full dose, raised the ratio of favorable estrogen breakdown products over 12 months at 300 mg a day [7], but 75 mg a day for 30 days did not [8]. Indole-3-carbinol shifts estrogen breakdown at 300 to 400 mg a day, while 50 to 200 mg did not work [9]. One serving gives 150 mg, so two servings a day are needed to reach the studied dose. Calcium glucarate was only tested inside a combination formula, so its own effect is unknown [10]. Most of these studies measured estrogen breakdown in urine, not symptoms. Animal and cell studies are never counted.
See all 52 studies →Hide the studies
- In a pooled analysis of six placebo-controlled studies of 718 women with cyclic breast pain, chasteberry (typically 20-40 mg a day for about 3 months) relieved breast pain more than placebo.Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A Systematic Review and Meta-Analysis.
- In three double-blind placebo-controlled trials of 520 women with premenstrual syndrome, women taking chasteberry extracts were 2.57 times more likely to have their symptoms go away than those taking placebo.Vitex agnus-castus in premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials.
- Across 14 trials in women with premenstrual syndrome, chasteberry showed a large benefit over placebo, but the studies had high risk of bias, very mixed results and likely publication bias, so the effect is probably overestimated.The treatment of premenstrual syndrome with preparations of Vitex agnus castus: a systematic review and meta-analysis.
- In four trials of about 500 women, chasteberry consistently eased premenstrual symptoms better than placebo, but more trials are needed.Herbal treatments for alleviating premenstrual symptoms: a systematic review.
- A review of trials of herbs, vitamins and minerals for premenstrual syndrome suggested chasteberry may be effective, but the evidence was weaker than for calcium.Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review.
- In a review of trials in menopausal women, chasteberry combined with St. John's Wort showed no better effect than placebo on menopausal complaints.Efficacy of Cimicifuga racemosa, Hypericum perforatum and Agnus castus in the treatment of climacteric complaints: a sys…
- A review of twelve randomised trials found chasteberry extracts beat placebo in most premenstrual syndrome trials and helped with latent high prolactin, with mild side effects, though results against a med for premenstrual dysphoric disorder were split.Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.
- A review of acupuncture and herbal trials for premenstrual syndrome, including chasteberry, found herbal treatments improved symptoms with no serious side effects, though the evidence was limited.Effects and treatment methods of acupuncture and herbal medicine for premenstrual syndrome/premenstrual dysphoric disord…
- All eight randomized trials reviewed found chasteberry helped premenstrual syndrome or premenstrual dysphoric disorder symptoms and it was well tolerated, though the trials differed in methods and extracts.Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review.
- A broad review of herbal remedies for polycystic ovary syndrome reported that chasteberry reduced hirsutism by lowering testosterone and androgen levels, with minimal side effects.Polycystic ovaries and herbal remedies: A systematic review.
- In 217 Chinese women with moderate to severe premenstrual syndrome, 40 mg of chasteberry extract for three cycles cut symptom scores significantly more than placebo, with no serious side effects.Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled …
- In 170 women with premenstrual syndrome, one chasteberry extract tablet daily for three cycles improved symptoms more than placebo, with 52% responders versus 24% on placebo.Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled stu…
- In 162 women with premenstrual syndrome over three menstrual cycles, a 20 mg daily dose of chaste tree extract Ze 440 reduced symptoms more than placebo, while 8 mg and 30 mg did not add benefit.Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome.
- In 148 premenopausal women taking three capsules a day of a blend containing indole-3-carbinol and green tea catechins for about 12 weeks, the urinary ratio of protective to risk-linked estrogen metabolites was markedly higher than on placebo.A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense® on 2-hydroxyestro…
- In 130 women taking tamoxifen for breast cancer, 300 mg a day of diindolylmethane for 12 months raised the urinary ratio of beneficial to less favorable estrogen metabolites and raised sex hormone-binding protein compared with placebo, but it did not change breast density and lowered tamoxifen metabolite levels.A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tam…
- In 128 women with premenstrual syndrome over six cycles, 40 drops of chaste tree extract taken before menses reduced symptoms more than placebo.Therapeutic effect of Vitex agnus castus in patients with premenstrual syndrome.
- In 108 university students with premenstrual syndrome, symptoms fell significantly over 2 menstrual cycles on chasteberry capsules alone, but a chasteberry and soy combination reduced psychological and total symptoms more than either alone.Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A…
- In 101 postmenopausal women taking a four-herb supplement containing chasteberry extract for 12 weeks, hot flushes, sweating, sleep problems, low mood and irritability improved more than with placebo, and C-reactive protein levels fell.Efficacy and Safety of Nutraceutical on Menopausal Symptoms in Post-Menopausal Women: A Randomized, Double-Blind, Placeb…
- In 100 late-perimenopausal or postmenopausal women over 16 weeks, a St. John's wort and chaste tree combination did not work better than placebo for hot flushes or other menopausal symptoms.Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial.
- In 96 pre- and post-menopausal women, 28 days of a combination formula that included calcium glucarate raised urinary 2-hydroxyestrogen levels compared with placebo, and the 2:16 ratio rose significantly in pre-menopausal women, but calcium glucarate was not tested on its own.Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking…
- In 67 Chinese women with moderate to severe premenstrual syndrome taking one daily tablet of chaste tree extract BNO 1095 for three cycles, the total symptom score and the negative mood and water retention scores improved more than with placebo.Treatment of moderate to severe premenstrual syndrome with Vitex agnus castus (BNO 1095) in Chinese women.
- In 67 Chinese women with moderate-to-severe premenstrual syndrome over three cycles, chaste tree extract improved all 17 tracked symptoms more than placebo, except lower abdominal cramping.Evaluating therapeutic effect in symptoms of moderate-to-severe premenstrual syndrome with Vitex agnus castus (BNO 1095)…
- In a double-blind trial of 60 postmenopausal women aged 50 to 70, 40 drops of vitagnus daily for eight weeks improved sexual function scores compared with placebo, with differences appearing by weeks six and eight.Vitagnus an estrogen-riched herbal remedy used in sexual dysfunction: A randomized clinical trial.
- In 60 premenopausal women with a low estrogen metabolite ratio, 75 mg a day of diindolylmethane for 30 days did not significantly raise the ratio compared with placebo, though body fat percentage fell more in the diindolylmethane group.Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Bod…
- In 60 women given 400 mg a day of indole-3-carbinol for 3 months, the urinary 2-hydroxyestrone to estriol ratio rose and stayed up, while fiber and placebo groups did not change; 3 of 20 women did not respond.Long-term responses of women to indole-3-carbinol or a high fiber diet.
- In 60 women at higher breast cancer risk given indole-3-carbinol for 4 weeks, doses of 300 to 400 mg a day raised the helpful estrogen metabolite ratio more than placebo, while 50 to 200 mg did not.Dose-ranging study of indole-3-carbinol for breast cancer prevention.
- In a double-blind trial of 52 menopausal women, eight weeks of chasteberry extract lowered overall menopausal symptom scores, anxiety, and hot flash-type symptoms more than placebo did.Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study.
- In 46 menopausal women with hot flashes taking citalopram, adding a chasteberry and black seed capsule for 8 weeks improved vasomotor, physical and psychosocial symptom scores more than citalopram with placebo.Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot f…
- In a double-blind placebo-controlled pilot trial of 42 women, a multi-ingredient supplement containing chaste berry for 3 months improved some mood and affective symptoms within the group, but showed no significant difference from placebo between groups.Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controll…
- In 41 women with premenstrual dysphoric disorder over 2 months, 57.9 percent (11 of 19) responded to chasteberry extract, a rate not significantly different from a med, though chasteberry eased physical symptoms more.Read the study on PubMed (12672170) →
- In 19 postmenopausal women with a history of early-stage breast cancer, 108 mg a day of diindolylmethane for 30 days significantly raised urinary 2-hydroxyestrone and cortisol versus placebo, while the rise in the 2-hydroxyestrone to 16-alpha-hydroxyestrone ratio (47%) was not statistically significant.Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a h…
- In a small subgroup of 14 late-perimenopausal women taking a chaste tree and St. John's wort tablet combination twice daily for 16 weeks, premenstrual-like symptoms improved more than with placebo on total score, depression, and cravings.Effects of a combination of Hypericum perforatum and Vitex agnus-castus on PMS-like symptoms in late-perimenopausal wome…
- In 8 women with endometriosis, adding diindolylmethane to dienogest for 3 months reduced pelvic pain and improved bleeding patterns more than dienogest alone.Comparison of dienogest effects upon 3,3'-diindolylmethane supplementation in models of endometriosis and clinical cases…
- In a randomized trial of women with premenstrual dysphoric disorder, chaste tree treatment was reported as effective with no side effects, and was compared with a med.[Psychic aspects of the premenstrual dysphoric disorders. New therapeutic strategies: our experience with Vitex agnus ca…
- In an open study of 1634 women with premenstrual syndrome over three cycles, 93% reported fewer symptoms or no symptoms, and 94% rated tolerance as good or very good; there was no control group.Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus.
- In an open-label study of 107 migraine-prone women with premenstrual syndrome taking 40 mg of chasteberry daily for 3 months, most reported less premenstrual symptoms and many had fewer migraine days, with no notable side effects.Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation.
- In two uncontrolled trials with 75 women, chasteberry essential oil was reported by participants to give strong relief from common menopausal symptoms, with some contraindications identified.Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwi…
- In 69 Japanese women with premenstrual syndrome taking 20 mg of chaste tree extract daily for three menstrual cycles, symptom scores fell over time and 91% were responders by the third cycle, with no serious side effects. There was no placebo group.Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospec…
- In an open-label real-world study of 59 women with premenstrual syndrome, 90 days of a vitex, vitamin B6, and magnesium tablet reduced pain and symptom severity and improved quality of life more than standard care alone, with no serious side effects.Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyri…
- In 50 women with premenstrual syndrome taking 20 mg of chasteberry extract daily for 3 menstrual cycles, symptom scores fell by 42.5 percent, and 20 of 43 completers had at least a 50 percent reduction.Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS).
- In 23 healthy BRCA gene carriers, 100 mg per day of diindolylmethane for 1 year was associated with reduced fibroglandular breast tissue on MRI, along with lower estradiol and testosterone levels, in a single-group study without a placebo.3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A pros…
- In 17 premenopausal women with lupus, 375 mg of indole-3-carbinol daily raised the urinary 2:16alpha hydroxyestrone ratio, with no clear change in lupus disease activity over 3 months.Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity.
- In 12 healthy adults taking indole-3-carbinol from cruciferous vegetables at about 6 to 7 mg per kg of body weight daily for 7 days, a liver enzyme measure of estradiol 2-hydroxylation rose about 50%, and urinary 2-hydroxyestrone relative to estriol also increased; there was no placebo group.Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol.
- In 5 overweight premenopausal women, 400 mg of indole-3-carbinol daily for two months increased estrogen 2-hydroxylation in urine.Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol.
- In patients with thyroid proliferative disease, 300 mg per day of diindolylmethane for 14 days was detected in thyroid tissue and shifted urinary estrogen metabolism toward the 2-hydroxyestrone form.3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study.
- In African-American women with the wild-type CYP1A1 gene, 5 days of 400 mg indole-3-carbinol daily raised the 2-OHE1 to 16-OHE1 ratio from 1.35 to 2.39.Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk.
- After 1 week of 500 mg indole-3-carbinol daily, estradiol 2-hydroxylation rose from about 29% to about 46% in humans.Induction of estradiol metabolism by dietary indole-3-carbinol in humans.
- In a retrospective study of 1700 women with menstrual disorders, three months of chasteberry extract products reduced irregular cycles and breast tenderness, and most women reported less bleeding, fewer periods with pain, and better quality of life.Use of Vitex agnus-castus in patients with menstrual cycle disorders: a single-center retrospective longitudinal cohort …
- In a retrospective laboratory database of 909 women taking diindolylmethane, urinary estrogen levels differed from non-users, and the protective-to-harmful estrogen metabolite ratio rose in a smaller before-and-after subset.Exploring the impact of 3,3'-diindolylmethane on the urinary estrogen profile of premenopausal women.
- In 108 postmenopausal women using an estradiol patch, concurrent diindolylmethane use was linked to significant changes in urinary estrogen profiles, with the clinical significance unknown.The impact of 3,3'-diindolylmethane on estradiol and estrogen metabolism in postmenopausal women using a transdermal est…
- In a prospective study of 30 perimenopausal women taking one multi-herb capsule daily for 60 days, menopause symptom scores fell sharply and most women reported resolution of hot flashes, sweating, anxiety, and low mood.Effectiveness of Multisymptom Support for Better Relief and Alleviation of Common Effects in Perimenopause (EMBRACE PERI…
- In a questionnaire survey, essential oils from the chaste berry and leaf were reported to be effective for menopausal symptoms, with the leaf oil also addressing psychological aspects.Vitexagnus-castus essential oil and menopausal balance: a self-care survey.
Review Totals and Summary
Members Only52 reviews · 90% positive
52 reviews · Amazon 49 · Supplementrelief 2 · Professionalsupplementcenter 1
90% positive7% neutral3% negative
Across the stores, NuMedica NuFemina shows 49 ratings (all listed under Amazon), but the themes below come from the single written review that could be read on its page, so this is one person's account rather than a broad pattern. What the reviewer praises: Adrienne A., a verified buyer who gave 5 out of 5 stars, says a care provider recommended the product for prolonged and intense premenstrual symptoms that lasted about 2.5 weeks before her period. She reports that within one month the intensity of her symptoms had noticeably reduced. Within three months the symptoms were minimal and lasted only about one week before menstruation. Her review is titled "Helped Regulate Cycle and Reduce PMS." Cycle regularity: She also says her cycles have become more regular. She describes this as notable because she historically had very irregular cycles due to PCOS. Complaints: None. The review contains no written complaints, side effects, or caveats. It says nothing about dosing problems, and it makes no comments on taste, form, or value, so nothing can be said on those points from the written feedback. Who it seems to suit: Based on this one review, it appeals to women dealing with long, intense PMS or irregular cycles, including those whose irregularity is linked to PCOS. The reviewer came to it on a care provider's recommendation and closes by encouraging others who struggle with PMS or irregular cycles to try it. The page also shows a Doctor Trusted Brand badge and a 100% would-recommend figure, but both come from this same single review and don't add independent evidence. How to weigh it: Because only one written review was readable, the points above are anecdotal. They show what happened for one customer and can't tell you how the capsules work for buyers in general, how common side effects might be, or how the product compares on price or taste. The other ratings on the page have no written text behind them in what was available, so their reasons are unknown. Other forms: The summary I worked from didn't mention any gummy, powder, or other non-capsule reviews, so nothing had to be left out on that account.
Biohacker Summary
Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it
Only three of the ten panelists spoke about Chaste Berry, the main ingredient, and all three use or recommend it. One uses it as a helpful herb, one recommends it to raise estrogen alongside DHEA, and one recommends it for women to raise progesterone and lower estrogen while warning men to be careful because it can have a 'chemical castration' effect. No doses, preferred forms or people who stopped were mentioned, and the most recent of these statements dates to 2024. Calcium is a smaller ingredient in this product, and the panel mostly favors getting it from food like sardines, dairy and leafy greens, with several warning against calcium supplements.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Chaste Berry · uses
- Uses Chaste Berry, also known as Vitex, as an herb that can be helpful.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
- Lists calcium as another important nutrient that people can be tested for and measured.
- States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
- Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
- Recommends calcium citrate, about 600 milligrams a day, for bone health, noting that much can also be obtained from diet through leafy greens, sesame seeds, tahini, and chia seeds.
- Dr. Hyman notes that while calcium deficiency is not common in terms of blood levels, insufficient intake can lead to osteoporosis as the body pulls calcium from bones. He advises caution with calcium supplementation due to potential heart issues.
- Dr. Hyman recommends Chaste Berry fruit extract (Vitex) for regulating menstrual cycles and helping with PMS.
- Mentions taking Chase Berry as an herb to help with progesterone levels.
- Notes that indole-3-carbinol was among the compounds identified to regulate inflammation in a clinical trial.
Thomas DeLauer · Chaste Berry · recommends
- Recommends Chaste Berry to stimulate estrogen and drive up estrogen levels, especially in tandem with DHEA.
- Takes Diindolylmethane (DIM) during muscle building phases.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
- Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
- Recommends providing the body with adequate dietary calcium, not a calcium supplement, to ensure a clean, strong spark for efficient insulin release.
- Warns that calcium and magnesium should not be taken together as they cancel each other out, though some products use delayed absorption to mitigate this.
- Warns that most people consume too much calcium relative to magnesium, which can disrupt the balance needed for proper bodily function, comparing it to an electrical circuit.
- Recommends DIM (Diindolylmethane) for modulating estrogen levels, which is important for both men and women as they age.
- Used to take DIM (Diindolylmethane) to control water retention for photo shoots, noting it made a big difference in lowering estrogen levels.
Ben Greenfield · Chaste Berry · recommends
- Recommends Chaste Berry for women to increase progesterone levels and reduce estrogen, but warns men to be careful as it can have a 'chemical castration' effect.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
- Warns that in high doses, calcium without the right cofactors can raise cardiovascular risk by contributing to arterial calcification instead of bone strength, and may increase the risk of osteoporosis.
- Explains that 10X separates calcium and zinc into different micro beads, releasing them at different rates and locations in the digestive tract to prevent competition and optimize absorption.
- Covers calcium as a key supplement for kids.
- Warns of calcium deficiency on a carnivore diet, as there is not an appreciable amount in meat, and recommends eating fish with bones or taking a calcium supplement or bone mineral matrix.
- Notes that excess calcium intake can contribute to calcium buildup in the arteries.
- Recommends indole-3-carbinol, found in cruciferous vegetables and supplementation form, for supporting phase one and phase two liver detoxification pathways.
- Notes that indole-3-carbinol, found in cabbage, broccoli, and Brussels sprouts, supports Phase 2 liver detoxification.
- Recommends purchasing indole-3-carbinol over DIM because it is more bioavailable and acts better for liver detoxification and estrogen metabolism, suggesting a dosage of around 400 milligrams a few times a day, totaling 1000 to 1500 milligrams.
Dr. Eric Berg · Calcium · neutral
- States that one can of sardines contains 382 mg of calcium.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Warns against calcium carbonate, calling it limestone and the worst source of calcium, stating it takes 12 steps to be converted in the body and is like eating rocks.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
- Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
Siim Land · Calcium · neutral
- Lists dairy and sardines as sources of Calcium.
- Notes that Boron reduces calcium/magnesium loss.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
- Mentions that eating enough calcium matters for bone density, but states that it alone won't transform bone density.
- Warns that calcium is linked to a higher risk of heart disease, though people with low calcium status and intake can take it safely.
- Warns that calcium supplements increase the risk of heart disease by raising blood calcium levels too high, leading to hypercalcemia and more calcium being stored in the arteries, and also increase the risk of arrhythmias.
- Warns against calcium supplementation for most people due to its association with increased cardiovascular events, but notes it can be useful for postmenopausal women with low bone density who don't consume dairy.
- Discusses Calcium as a supplement.
- Recommends consuming calcium from dairy, tofu, leafy greens, and bones, as it is a key nutrient required for ATP synthase in mitochondrial energy production.
- Recommends diindolylmethane, found in cruciferous vegetables, as an epinutrient that favorably influences epigenetics, is anti-inflammatory, anti-cancer, antioxidant, and neuroprotective.
Dr. Rhonda Patrick · Calcium · neutral
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
- Takes a calcium-magnesium pill because he believes people tend to be short of both and that the body cares about the ratio of these similar molecules.
- States that 1,000 milligrams of calcium per day is the recommended intake for bone density, and supplementation is an option if this requirement is not met.
- Takes a calcium, vitamin K2, and vitamin D combination supplement in the morning, providing about 600 mg of calcium and another 1,000 IUs of vitamin D.
- Dr. Rhonda Patrick discusses calcium needs.
Dave Asprey · Calcium · neutral
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Recommends taking calcium citrate during a high oxalate meal to bind the oxalate in the gut.
- Notes that people often take calcium for bone health.
- Believes calcium supplements are overrated, as most people need more vitamin K2 and vitamin D instead.
- Advises taking iron and calcium separately because they will bind together.
- Takes extra calcium to help deal with the burden when eating chocolate or anything with higher levels of oxalates.
- Discusses calcium citrate as a counter to oxalate crystals, specifically when consumed through dairy, but questions if it's the primary form of calcium in dairy.
- Discusses Diindolylmethane (DIM) as a supplement that can help with estrogen dominance.
- Discusses Diindolylmethane (DIM) as a compound found in cruciferous vegetables that experts advise for hormone regulation, particularly for those at risk for breast cancer, acne, and weight issues.
Peter Attia · Calcium · recommends
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
- Suggests that calcium is one of the other signals involved in regulating mitochondrial number, beyond AMPK activation.
- States that in postmenopausal women not on estrogen, calcium and vitamin D have no protective effect against hip fracture because the problem is not the shell of the bone, which is fed by calcium and vitamin D, but the internal girder network.
- Notes that compelling evidence links calcium to reduced risk of osteoporosis, which can impact mortality from specific causes.
Bryan Johnson · Calcium · recommends
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends calcium at 1,200 mg daily for women during the follicular phase, depending on dietary intake.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
Andrew Huberman · Calcium · neutral
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Adequate intake of calcium is vital for bone health.
RAL Summary
Members OnlyTier 3 for Hormone Balance for Women
Tier 3 fits: 90% of 52 reviews are positive, and chaste berry has strong human support for premenstrual symptoms, with 31 of 35 studies showing improvement [1][2]. There are too few reviews for tier 2.
Take 2 servings a day (6 capsules) to match the dose that worked in the studies.
Where the evidence disagrees: 5 of the 52 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Reproductive system, Endocrine system
Combine with: For hormone balance, NuFemina pairs well with magnesium glycinate for mood, sleep, and muscle relaxation, vitamin D3/K2 for bone support during perimenopause and menopause, and omega-3 fish oil for inflammation and cardiovascular health. Additional options include a methylated B-complex to aid estrogen detoxification, probiotics to support estrogen clearance through the gut, and ashwagandha or adaptogens for stress-related hormone swings. If blood pressure is the actual goal, consider a separate cardiovascular product such as magnesium, CoQ10, potassium-rich support, hawthorn, or beet root, and consult a healthcare provider before combining with any meds.
Possible side effects: No serious side effects were reported in the chaste berry trials. Diindolylmethane lowered tamoxifen breakdown product levels in women on tamoxifen, so people on that drug should take care.
Supplement Facts
Calcium D-Glucarate 1000 mg · Chaste Berry 225 mg · Diindolylmethane 200 mg
Supplement Facts
Serving Size 3 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Calcium D-Glucarate | 1,000 mg | † |
| Chaste Berry | 225 mg | † |
| Diindolylmethane | 200 mg | † |
| Indole-3-Carbinol | 150 mg | † |
† Daily Value not established.
Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.
Directions: Directions: Take three capsules once per day or as directed by your healthcare practitioner.
Barcode (UPC) 812527013155 · Label source: NIH label database · Report a label change
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Members OnlyThe highest ranked for the same goal
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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