NutraBio Mega Greens Review
Give your body the daily foundation it needs to show up fully, for the moments that matter most. NutraBio Mega Greens is a comprehensive daily superfoods supplement built for people who understand that how you feel on the inside determines how much you can do on the outside. When your energy is steady, your gut is balanced, and your immune system is strong, everyday life simply feels better. Powered by patented, science-backed ingredients including BettaBerries, CherryPURE, Green Balance Alkalizing Blend, and DigeZyme multi-enzyme complex, Mega Greens supports the areas of your health that make the biggest difference day to day. More natural energy to keep you going. Better digestion to help your body absorb the nutrients it needs. Stronger immune defense to stay consistent and keep life moving forward. And antioxidant protection to help your body recover and feel its best from the inside out. The product page also describes it as a greens powder with 26 superfoods, prebiotic fiber, adaptogenic mushrooms, and patented ingredients, covering energy, immunity, digestion, and antioxidant protection. DigeZyme multi-enzyme complex supports gut function, while BettaBerries and CherryPURE provide targeted antioxidant support. The Green Balance Alkalizing Blend brings organic greens into every serving, and the Adaptogen Mushroom Blend featuring Cordyceps, Reishi, Lion's Mane, Shiitake, and Turkey Tail is listed to support resilience and long-term vitality. The page states there are no fillers and no shortcuts. It lists 26 superfoods, 2 g prebiotic fiber, 1.5 g antioxidant berry complex, and 1 g adaptogenic mushrooms. The product is described as made in the USA, third-party tested, with fully transparent labels and fully dosed formulas, manufactured in an FDA-registered facility under c-GMP. The label is listed as gluten free, non-GMO, vegetarian, hypoallergenic, lactose free, and kosher. Directions: mix one serving, one scoop, with 8 to 12 oz of water or juice and consume one to two times daily, or add to a smoothie, stir into yogurt, or blend into a shake. Flavors offered are Original, Wild Berry, and Citrus. The product is sold with a Forever and a Day guarantee allowing returns or exchanges anytime for any reason, with refunds within 90 days of purchase and exchanges beyond that. Free shipping applies to continental US orders over $99. Subscription options offer up to 25 percent off with recurring deliveries every 30, 60, or 90 days.
Tier ⓘ
Tier 4 · Rank 24
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 24 within Tier 4 for Energy; 73 of 110 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
61 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
96% of 42
Biohacker Mentions
10 of 10
Cost per month
$50
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Study, Trial or Testing Result Summary
Members Only131 human studies · 64 improved
30 of these 131 human studies gave the ingredient by drip or injection, not by mouth.
131 human studies64 improved51 no effect60,701 people studied
Tart cherry powder is at a dose in line with the studies. In 50 middle-aged adults, daily Montmorency cherry for 3 months improved alertness and lowered mental fatigue [1]. A large review found small endurance gains from polyphenol-rich foods including tart cherry [2], but several small trials found no change in cycling performance or recovery [3]. The mushroom blend gives 2 grams a day, but it is split across five mushrooms and the amount of each is not shown. Reishi alone at 1000 milligrams improved fitness and well-being in 78 students [4], while a Cordyceps and Reishi product did nothing in 96 students [5]. Vitamin C here is below the 250 milligrams that helped tired young adults who were low in vitamin C [6], and it showed no benefit in people who were not low [7]. Iron is at a low dose. It eases tiredness mainly in people who are short of iron [8]. Calcium is only a trace amount. The chicory fiber has only thin, mixed results for fatigue [9]. The green and berry blends have no human studies for energy. Animal and cell studies are never counted.
See all 131 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 33 trials of 4558 women with anaemia after childbirth, intravenous iron probably reduced fatigue slightly within 8 to 28 days compared with oral iron, though most evidence was low or very low certainty.Treatment for women with postpartum iron deficiency anaemia.
- In 20 trials of 4196 women with anaemia after childbirth, intravenous iron reduced fatigue more than oral iron, and also raised haemoglobin and ferritin, with low to moderate quality evidence.Intravenous iron versus blood transfusion for postpartum anemia: a systematic review and meta-analysis.
- In 18 studies of 1408 children, teens and menstruating adults without anaemia, iron supplementation reduced fatigue and improved anxiety, well-being and memory in placebo-controlled trials, but the effects were absent when people without iron deficiency were included.Psychiatric and cognitive outcomes of iron supplementation in non-anemic children, adolescents, and menstruating adults:…
- In 18 trials of 1170 iron-deficient adults without anaemia, iron reduced self-reported fatigue but did not improve measured physical capacity such as oxygen uptake.Efficacy of iron supplementation on fatigue and physical capacity in non-anaemic iron-deficient adults: a systematic rev…
- In 11 trials of 1074 adults with iron deficiency but no anaemia, intravenous iron slightly raised haemoglobin, but the evidence for fatigue and oxygen uptake was very low quality and too uncertain to show benefit.Intravenous iron therapy for non-anaemic, iron-deficient adults.
- In two placebo-controlled trials of 404 adults with Charcot-Marie-Tooth disease type 1A, ascorbic acid at two doses over 12 to 24 months had little meaningful effect on fatigue.Interventions for fatigue in peripheral neuropathy.
- In four placebo-controlled trials of people with iron deficiency anaemia, intravenous ferumoxytol improved fatigue scores and haemoglobin without raising adverse events.The Efficacy of Ferumoxytol for Iron Deficiency Anemia: A Meta-Analysis of Randomized Controlled Trials.
- Across 118 trials of nitrate- and polyphenol-rich foods, polyphenol foods including Montmorency cherry gave small but significant endurance performance benefits.Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systema…
- Across nine studies of 720 people, three of four controlled trials found intravenous vitamin C lowered fatigue scores more than control, and four of five uncontrolled studies saw fatigue fall.Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review o…
- A review of 37 studies in cancer patients found intravenous vitamin C may ease fatigue and other symptoms, but the evidence is preliminary and mostly uncontrolled.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of supplements for football players said vitamin C may improve performance by lowering oxidative stress, but gave no numbers and called for more research.The efficacy of dietary supplements on health status and performance of football players: a systematic review.
- In a review of 24 studies of supplements in wrestlers, iron supplementation improved recovery and may improve exercise performance, though effects were often small and results mixed across supplements.Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review.
- In 8112 healthy French adults, a daily antioxidant capsule containing 120 mg vitamin C for about 6 years did not change quality of life scores, including vitality, compared with placebo.Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, pla…
- In 812 adults with iron deficiency anaemia who could not use oral iron, intravenous ferumoxytol over 5 weeks improved fatigue scores more than placebo, and 81.1% reached the haemoglobin target versus 5.5% on placebo.Efficacy and safety of IV ferumoxytol for adults with iron deficiency anemia previously unresponsive to or unable to tol…
- In 697 adults with mild high blood pressure, a low-sodium, high-potassium diet with placebo for 6 months was linked to more fatigue (34%) than the usual diet (18%) or a weight loss diet (15%).Effect of antihypertensives on sexual function and quality of life: the TAIM Study.
- In 405 non-anemic blood donors with low iron stores, a single 800 mg iron infusion raised ferritin and hemoglobin but did not change fatigue scores compared with placebo at 6 to 8 weeks.The effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron defic…
- In 399 anemic patients after a long intensive care stay, hepcidin-guided intravenous iron (1 g) did not shorten later hospital stay and the abstract reports no fatigue result, though 90-day deaths were lower (8% vs 16.6%).Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU st…
- In an open-label randomized trial of 338 adults with iron deficiency anemia, high-dose intravenous iron raised hemoglobin faster than oral iron and improved fatigue scores more by 4 weeks, with similar side effect rates.[Comparison of the efficacy and safety between high-dose intravenous iron and oral iron in treating iron deficiency anem…
- In 304 iron-deficient heart failure patients, intravenous iron for 52 weeks improved walking distance by 33 m at 24 weeks and improved fatigue score and quality of life compared with placebo.Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart f…
- In 290 fatigued, iron-deficient women, a single 1000 mg iron infusion reduced fatigue in 65.3% versus 52.7% with placebo at 8 weeks, and improved mental quality of life and cognitive function.Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women--PREFER a randomized, placebo-con…
- In 275 adults with early COVID-19 given a 10-day combination that included vitamin C, less fatigue at day 14 was seen only when famotidine was added, not with the vitamin C combination alone.Read the study on PubMed (41693032) →
- In 271 adults with Charcot-Marie-Tooth disease type 1A, 1.5 g of ascorbic acid daily for 2 years did not differ from placebo on neuropathy or on secondary outcomes including fatigue.Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement for 33 days improved vigour, stress and mental health ratings and made them feel less mentally tired than placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 202 hemodialysis patients, a multinutrient supplement containing vitamin C for 12 weeks did not reduce fatigue compared with placebo, though some heart rate variability measures improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 198 nonanemic menstruating women with low ferritin and fatigue, 80 milligrams of elemental iron daily for 12 weeks reduced fatigue more than placebo, though quality of life did not change.Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled tri…
- In 176 iron-deficient blood donors, intravenous or oral iron over 8 to 12 weeks significantly reduced fatigue and improved sleep, with no difference between the two forms.The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in I…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 14 days improved vitality and motivation, but blood vitamin C did not explain these benefits.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit gave somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In 160 heart bypass surgery patients, vitamin C plus omega-3 fatty acids given from the day before surgery through the first 5 days after reduced post-operative fatigue more than placebo.The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass gra…
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In a double-blind placebo-controlled trial of 144 non-anemic women with unexplained fatigue, 80 mg daily of oral iron for 4 weeks reduced fatigue more than placebo, with the benefit seen mainly in women with low or borderline ferritin.Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial.
- In 141 healthy office workers, a single 10 gram intravenous vitamin C dose lowered fatigue scores for up to one day compared with saline placebo, especially in those with low starting vitamin C, and also lowered oxidative stress.Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
- In 112 women with postpartum anemia taking 600 mg daily of ferrous fumarate for 4 weeks, adding folic acid did not change fatigue scores or health status compared with iron alone.A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartu…
- In 110 premenopausal women with iron-deficiency anemia from fibroids, both groups took 325 mg iron three times daily for 12 weeks, and adding a goserelin injection raised blood hemoglobin more than a sham injection did; the abstract does not test iron alone against no iron and reports no energy or fatigue result.Goserelin acetate 10.8 mg plus iron versus iron monotherapy prior to surgery in premenopausal women with iron-deficiency…
- In 100 pregnant women with iron deficiency anemia over 12 weeks, intravenous ferric carboxymaltose gave greater fatigue improvement than iron sucrose and needed fewer visits.Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- rando…
- In a 3-month double-blind trial of 99 people with severe kidney failure taking 250 mg vitamin C three times weekly, symptoms including fatigue were similar to placebo, and nausea trended worse with vitamin C.Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
- In 97 people with inflammatory bowel disease and iron deficiency anemia, fatigue scores improved over 5 weeks after intravenous iron with both products, but improvement was slower and smaller with ferric carboxymaltose.Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due …
- In 97 people with inflammatory bowel disease and iron deficiency anemia, intravenous iron over about 10 weeks improved vitality scores, a measure of energy, with larger gains after ferric derisomaltose than ferric carboxymaltose.Hypophosphatemia attenuates improvements in vitality after intravenous iron treatment in patients with inflammatory bowe…
- In 96 healthy young physical education students, 28-33 days of a Cordyceps and Reishi supplement at low or high dose did not change maximal oxygen use, anaerobic power or fatigue compared with placebo.Effects of a Commercial Supplement of Ophiocordyceps sinensis and Ganoderma lucidum on Physiological Responses to Maxima…
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 90 premenopausal women with fatigue and low ferritin, one 800 mg intravenous iron dose cut fatigue more than placebo only in women with ferritin of 15 or lower, where 82% of iron-treated women reported improvement; the overall difference was not significant.Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration.
- In 86 people with mental fatigue, a single dose of homeopathic potassium phosphate taken before an attention test did not work better than placebo, though the test's ceiling effect limits the result.Homeopathy for mental fatigue: lessons from a randomized, triple blind, placebo-controlled cross-over clinical trial.
- In 85 female blood donors, one 1000 mg intravenous iron isomaltoside dose raised hemoglobin more than placebo, but fatigue differences were only numerical and the trial was not powered for symptoms.Intravenous iron isomaltoside improves hemoglobin concentration and iron stores in female iron-deficient blood donors: a…
- In 78 female college students, 1000 mg daily of Reishi for 30 days improved heart rate, maximal oxygen use, work capacity, grip strength, and well-being scores compared with placebo.Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Str…
- In 60 older adults with frailty taking an inulin and fructooligosaccharide prebiotic for 13 weeks, exhaustion and handgrip strength improved versus placebo, but overall frailty, daily function, cognition and sleep did not change.Effect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial.
- In 58 healthy adults with mild prolonged tiredness, a supplement combining pomegranate extract with B vitamins and vitamin C reduced fatigue scores over 8 weeks compared with placebo, though vitamin C was not tested alone and biochemical markers did not change.Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monoce…
- In 53 female athletes with low iron stores, 20 mg iron plus a probiotic raised ferritin more than iron alone but not significantly, and increased vigor at 12 weeks, with no clear effect on physical performance.The Effect of Lactobacillus plantarum 299v on Iron Status and Physical Performance in Female Iron-Deficient Athletes: A …
- In 50 middle-aged adults, 60 ml a day of Montmorency cherry for 3 months improved sustained attention and alertness and lowered mental fatigue ratings compared with placebo.Polyphenol-rich tart cherries (Prunus Cerasus, cv Montmorency) improve sustained attention, feelings of alertness and me…
- In healthy young adults with low vitamin C levels, 500 mg twice a day for 4 weeks improved attention and work absorption compared with placebo, with a trend toward less fatigue.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In a 28-day placebo-controlled trial of 46 adults with long COVID, twice-daily liposomal vitamin C (500 mg) with l-arginine reduced persistent fatigue (2 of 23 still fatigued vs 21 of 23 on placebo) and improved walking distance and handgrip strength.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 40 young adults with low vitamin C, 1000 mg daily for 4 weeks improved mental vitality and reduced inflammation compared with placebo, with gut bacteria changes linked to the gains.Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitam…
- In 36 volunteers, 1 g of vitamin C daily for 30 days improved maximal oxygen uptake and lowered oxidative stress only in those with the lowest vitamin C levels, and it did not reduce fatigue index.Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
- In 30 women with gynecological disease and anemia before surgery, 100 mg daily iron for at least 10 days raised hemoglobin but did not significantly reduce fatigue; adding Ninjin'yoeito reduced fatigue.Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxie…
- In 30 healthy adults given a single 25 g inulin dose, the study tested an enzyme that reduced fatigue and stomach symptoms versus placebo, so it does not show that inulin itself improves energy.Oral Fructanase Administration Reduces Gastrointestinal Symptom Severity after Acute Inulin Challenge in Healthy Adults.
- In 28 men with marginal vitamin C status, 1000 mg daily for 8 weeks produced a physical activity rise that was not statistically significant compared with placebo, though cold episodes were fewer.Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vit…
- In 28 people given 4 g daily of a Cordyceps militaris mushroom blend, one week showed no significant change in exercise measures, but after 3 weeks (10 people) maximal oxygen use and time to exhaustion improved compared with placebo.Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation.
- In 26 overweight middle-aged women doing aerobic training for 3 months, drinking 500 mL of orange juice daily was linked with lower blood lactate, suggesting less muscle fatigue than training alone.Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training.
- Eating two SunGold kiwifruit daily for 4 weeks improved mood disturbance, wellbeing and vitality compared with usual diet in 26 adults with mild to moderate mood disturbance.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 26 recreationally active women with iron deficiency but no anemia, one intravenous iron treatment compared with placebo improved fatigue scores at 4 weeks.Effect of intravenous iron therapy on exercise performance, fatigue scores and mood states in iron-deficient recreationa…
- In 25 healthy young adults, a single dose of a pre-workout drink containing 500 mg vitamin C along with other ingredients raised self-rated energy and vigour compared with placebo, though adding synephrine gave no extra benefit.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 breast cancer survivors, 500 mg vitamin C plus vitamin E daily for 10 weeks alongside strength training did not reduce fatigue more than placebo.Effect of strength training and antioxidant supplementation on perceived and performance fatigability in breast cancer s…
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 24 stroke patients in rehabilitation, one sachet a day for 8 weeks of a vitamin and mineral blend that included copper reduced motor, cognitive and total fatigue more than rehabilitation alone, though copper was not tested by itself.The role of nutritional supplement on post-stroke fatigue: a pilot randomized controlled trial.
- In 24 recreational athletes doing three weeks of interval training, a multi-ingredient blend including Cordyceps improved critical running speed and lean mass versus placebo, though both groups improved maximal oxygen use.The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intens…
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during exercise compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In 20 iron-depleted women without anemia, 6 weeks of iron supplements, compared with placebo, reduced muscle fatigue during repeated knee-extension exercise and raised muscle strength later in the test.Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, non…
- In 20 active women with low iron stores, 100 mg of daily iron for 8 weeks raised maximal oxygen uptake above the placebo group and lowered blood lactate after exercise, though the rise in endurance time was not statistically significant.Effects of iron repletion on VO2max, endurance, and blood lactate in women.
- In 18 healthy volunteers, 1000 mg a day of ascorbic acid for 8 days did not reduce physical fatigue during a long cycling task, while a different product did.Effects of Applephenon and ascorbic acid on physical fatigue.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 18 iron-depleted female runners, 8 weeks of oral iron raised iron stores but did not improve endurance time to exhaustion compared with placebo.Effect of iron supplementation on endurance capacity in iron-depleted female runners.
- In 17 people doing hard cycling at high altitude, a 3-week broad antioxidant capsule that included vitamin C did not improve performance; a different supplement combination did better than both this capsule and placebo.Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.
- In 17 amateur cyclists, two weeks of a Cordyceps and Rhodiola formula did not change oxygen use, time to exhaustion or power compared with placebo.Effects of a commercial herbal-based formula on exercise performance in cyclists.
- In a placebo-controlled trial of 16 iron-depleted female athletes, intramuscular iron injections raised serum ferritin but did not improve submaximal or maximal aerobic exercise performance compared with placebo over about 4 weeks.Effect of iron injections on aerobic-exercise performance of iron-depleted female athletes.
- In 15 iron-deficient elite runners, a single 500 milligram intravenous iron injection improved iron levels for 4 weeks but did not improve time to exhaustion compared with placebo.Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.
- In 15 highly trained cyclists taking 1000 mg of bromelain daily or placebo across a six-day stage race, muscle damage markers rose equally in both groups, but the bromelain group reported less fatigue on day four and showed a trend toward keeping testosterone levels steadier.Acute protease supplementation effects on muscle damage and recovery across consecutive days of cycle racing.
- In 14 healthy volunteers, 3000 mg a day of ascorbic acid for 8 days did not change physical fatigue during a long cycling task compared with placebo.Daily oral administration of crocetin attenuates physical fatigue in human subjects.
- In a placebo-controlled trial of 14 distance runners without clinical iron deficiency, three 100 mg intravenous iron injections over 4 weeks reduced perceived fatigue and mood disturbance by week 6, without improving running performance.Four weeks of IV iron supplementation reduces perceived fatigue and mood disturbance in distance runners.
- In 13 men, 500 mg of tart cherry extract for 7 days reduced oxidative stress and muscle damage markers after hard squats and prevented the drop in handgrip strength versus placebo.Broad Spectrum Polyphenol Supplementation from Tart Cherry Extract on Markers of Recovery from Intense Resistance Exerci…
- In 13 healthy people, 5 days of tart cherry lengthened time to exhaustion in low-oxygen cycling (940 vs 912 seconds) compared with placebo.Five Days of Tart Cherry Supplementation Improves Exercise Performance in Normobaric Hypoxia.
- In 12 middle-aged triathletes during a 90-minute cycling session, taking vitamin C with glutathione improved energy-related metabolic and heart measures and lowered an oxidative stress marker compared with placebo, though vitamin C was not tested alone and this was a single acute session.Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Perf…
- In 12 young men, a single 1 g dose of Cordyceps militaris extract gave faster post-exercise reaction times and higher resting oxygen uptake than placebo, but did not change peak exercise oxygen use.Acute Cordyceps militaris supplementation and elevated resting oxygen uptake with faster reaction times: A randomized cr…
- In 12 recreational cyclists, tart cherry juice for 4 days before and 2 days after exercise did not improve time trial, fuel use or recovery compared with a sports drink.The effect of tart cherry juice compared to a sports drink on cycling exercise performance, substrate metabolism, and re…
- In 12 healthy young adults, 5 days of tart cherry did not change blood pressure drop after low-oxygen exercise or the energy spent exercising compared with placebo.Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.
- In 10 trained cyclists, a single 30 ml dose of tart cherry juice raised peak sprint power and total work in a 60-second all-out sprint by about 10% and lowered systolic blood pressure by 5 mm Hg compared with placebo, but did not change time to exhaustion.Effects of montmorency tart cherry (L. Prunus Cerasus) consumption on nitric oxide biomarkers and exercise performance.
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In eight men, a glucose drink lowered blood potassium during and after intense cycling, but it did not delay fatigue compared with placebo.A single oral glucose load decreases arterial plasma [K+ ] during exercise and recovery.
- In 8 male cyclists given a cordyceps and rhodiola formula or placebo, there were no significant differences in muscle oxygen saturation, maximal oxygen use, or time to exhaustion during cycling tests.Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen sat…
- In 7 well-trained runners, drinking a prescribed volume of a potassium-containing carbohydrate-electrolyte drink during 4 hours of recovery from a long run let them keep running about 16% longer later than drinking as much as they wanted.Influence of fluid intake pattern on short-term recovery from prolonged, submaximal running and subsequent exercise capa…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In a randomized trial of pregnant people in their second trimester with iron deficiency anemia, a 27 mg iron tablet over 4 weeks raised hemoglobin as much as 100 mg ferrous ascorbate, improved dizziness, fatigue and palpitations more, and caused no side effects.Efficacy and safety of emulsified microsomal ferric pyrophosphate vs. Ferrous Ascorbate in pregnancy with iron-deficienc…
- In an open-label quasi-randomized trial of 1066 women with postpartum anemia, the herbal formula Ninjin'yoeito reduced fatigue over 4 weeks, while oral iron did not, although both raised hemoglobin by similar amounts.A quasi-randomized controlled trial of Ninjin'yoeito for the treatment of postpartum anemia and the prevention of postpa…
- In 155 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks only marginally improved mood until day 12, with effects weaker than kiwifruit, though mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 61 hemodialysis patients, 100 mg of intravenous vitamin C after each session for 6 months did not improve energy-related quality of life or red blood cell production compared with no vitamin C.Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients.
- In 29 men with Gulf War Illness, lower-dose Reishi did not change symptom severity compared with placebo and higher-dose Reishi made symptoms worse over 30 days each.A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Gano…
- In 24 healthy men, a single dose of a Cordyceps-containing supplement had no effect on jump height, strength or endurance compared with placebo.Effects of a supplement designed to increase ATP levels on muscle strength, power output, and endurance.
- In 12 healthy volunteers breathing low-oxygen air, one intravenous iron sucrose dose or saline placebo before 8 hours of low oxygen did not change maximal exercise capacity overall.Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen a…
- In 12 healthy men, six days of Montmorency cherry supplement did not change muscle oxygen, blood nitrate or cycling endurance compared with placebo.Montmorency cherry supplement does not affect aerobic exercise performance in healthy men.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- In 11 professional rugby league players, Montmorency cherry juice around a match did not change fatigue, mood, soreness or inflammation markers compared with placebo.Montmorency tart cherry juice does not reduce markers of muscle soreness, function and inflammation following profession…
- In 8 people with COPD, a single 2 g IV vitamin C dose compared with saline reduced quadriceps neuromuscular fatigue and lowered inflammatory C-reactive protein during exercise, but did not improve breathlessness or exercise tolerance.Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise…
- In 7 male triathletes, 6 weeks of a daily antioxidant capsule containing 600 mg ascorbic acid did not change maximal oxygen uptake or muscle fatigue compared with placebo.No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabo…
- In a Sri Lankan tea plantation, anemic workers given iron picked significantly more tea over one month than those given placebo, and their daily activity levels also rose.Iron-deficiency anaemia and its effect on worker productivity and activity patterns.
- In 214 outpatients with COVID-19, 8000 mg ascorbic acid for 10 days did not shorten symptoms, including fatigue, compared with usual care.Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulator…
- In 201 pregnant women with persistent iron deficiency, a single 1000 mg intravenous iron dose improved fatigue more than daily oral iron at weeks 3 and 6, and the women stayed non-anemic for longer.Intravenous ferric derisomaltose versus oral iron for persistent iron deficient pregnant women: a randomised controlled …
- In 85 women with severe fatigue after postpartum hemorrhage, a single 1200 milligram intravenous iron isomaltoside dose reduced physical fatigue more than oral iron over 12 weeks.Intravenous iron isomaltoside treatment of women suffering from severe fatigue after postpartum hemorrhage.
- In a single-arm study of 78 pregnant people with iron deficiency anemia, one 1000 mg intravenous dose of ferric derisomaltose raised mean hemoglobin by 1.3 g/dL by delivery and improved self-reported fatigue, with no major infusion reactions.Efficacy of Single-Dose Intravenous Ferric Derisomaltose for Iron Deficiency Anemia in Pregnancy.
- In an open-label trial of 40 head and neck cancer survivors, 100 mg vitamin C tablets daily for 8 weeks gave less fatigue relief than Tualang honey.Effects of Tualang Honey on Cancer Related Fatigue: A Multicenter Open-label Trial of H&N Cancer Patients.
- In 39 advanced cancer patients with cachexia, a 4-month combined treatment including 500 mg daily vitamin C improved fatigue scores and lowered inflammatory markers, but the study had no placebo group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In 37 people with relapsing multiple sclerosis taking an oligofructose-enriched inulin prebiotic for 6 weeks, patient-reported symptoms including fatigue did not significantly improve, though the supplement was well tolerated.A randomized cross-over trial of prebiotics and probiotics in multiple sclerosis: Trial feasibility, supplement tolerabi…
- In a small uncontrolled pilot of 23 iron-deficient women, a daily food-derived supplement that also contained vitamin C was taken for 8 weeks, and self-reported energy improved, though vitamin C alone was not tested and there was no placebo group.A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Def…
- In an uncontrolled pilot study of 23 young women with iron deficiency anemia, 160 mg daily of ferrous sulfate for 8 weeks lowered fatigue scores and improved muscle endurance, but did not improve aerobic fitness or muscle strength.Efficacy of 8-week oral iron supplementation on fatigue and physical capacity in young women with iron deficiency anemia…
- In 20 adolescent girls with iron deficiency and fatigue, intravenous iron sucrose led to clinically meaningful fatigue improvement in 19 of 20 at 6 weeks, with no control group.Intravenous iron therapy in non-anemic iron-deficient menstruating adolescent females with fatigue.
- In 14 people taking a combined cat's claw and mushroom extract formula for 4 weeks, reported pain and fatigue decreased, and a marker of DNA damage fell, though the study had no control group.Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements.
- In a small uncontrolled pilot of 10 homeless women taking alternate iron supplements for three months with nurse home visits, fatigue decreased and blood hematocrit rose, with few side effects.Side effects of alternative iron supplementation: a pilot study.
- In a survey of complementary medicine practitioners giving IV vitamin C (average 28 g every 4 days), 59 of 9,328 patients with data had lethargy or fatigue as a side effect, and most side effects were minor.Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
- In 1,643 Spanish adults aged 65 and over followed for about 3.5 years, low dietary vitamin C intake was linked to a higher risk of frailty, which includes exhaustion, but this link was not statistically significant on its own.Low vitamin intake is associated with risk of frailty in older adults.
- In a survey of 1374 Chinese cancer patients who used Reishi mushroom, 52 percent said their fatigue improved quite a bit or very much; this self-reported survey has no control group and does not measure energy directly.Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients.
- In a 90-day follow-up of 923 Indonesian COVID-19 survivors, vitamin C combined with other micronutrients and favipiravir did not significantly change post-COVID symptoms, including fatigue, which was the most common symptom.Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: A longitudinal study.
- In a survey of 576 people in Syria who had COVID-19, 76.4% reported using vitamin C, but the survey did not measure whether vitamin C improved energy or fatigue, and fatigue was the most reported symptom.COVID-19 infected patients' experiences in Syria, and the role of the pharmacists during their infection.
- In 411 dentists and their wives, people who took little vitamin C reported about double the number of fatigue symptoms compared with those who took more.Daily vitamin C consumption and fatigability.
- In 186 cancer patients with iron deficiency, intravenous iron was followed by better quality of life, fatigue scores, and physical function, though there was no control group.Impact of Iron-Deficiency Management on Quality of Life in Patients with Cancer: A Prospective Cohort Study (CAMARA Stud…
- In a retrospective German cohort of 125 breast cancer patients, adding intravenous vitamin C of 7.5 g for at least 4 weeks was associated with fewer treatment side effects, including fatigue, than no added vitamin C.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- In a retrospective chart review of 86 cancer patients given high-dose IV vitamin C (50 to 150 g per infusion), patients overall reported improved fatigue, pain, and mood, with temporary nausea and injection-site discomfort as the most common side effects.Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.
- In 67 adults with shingles, about 2 weeks of intravenous vitamin C alongside standard treatment was followed by reduced pain and less general fatigue, but the study had no placebo group.Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study.
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- In 60 healthy volunteers, 28 days of Cordyceps cicadae mycelium improved visual sharpness and reduced reported eye fatigue, with no change in eye measurements.Evaluation of the Impact of Cordyceps cicadae Mycelium on Vision Health: A Cohort Study.
- In adults with hypophosphatasia, a higher calcium to phosphorus intake ratio was associated with more tiredness and fatigue, and very high or very low calcium intake was linked to more symptoms, based on a 7-day diary.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- In 40 octogenarians with anemia and resistant heart failure, a combined treatment of erythropoietin and intravenous iron sucrose improved heart function, shortness of breath, and fatigue, though iron was not tested alone.Effect of correction of anemia with erythropoietin and intravenous iron in resistant heart failure in octogenarians.
- In 21 patients with inflammatory bowel disease who finished 8 weeks of oral liposomal iron, fatigue scores fell by an average of 9.2 points in an uncontrolled pilot study.Treatment of iron deficiency anemia with liposomal iron in inflammatory bowel disease: efficacy and impact on quality of…
Review Totals and Summary
Members Only42 reviews · 96% positive
42 reviews · Amazon 30 · NutraBio 12
96% positive4% neutral0% negative
Buyers of NutraBio Mega Greens powder are positive. Across the stores it carries about 42 ratings, and the written feedback is short, consistent and free of complaints. **What buyers say it did for them:** The clearest benefit reported is regularity. One buyer says it "definitely helps me stay regular." Another takes it each morning before work and says they "feel really good" with it, and describes a clean feeling. One buyer who takes it with a kidney supplement plans to keep going "to see the results," so has not yet reported a definite outcome. Beyond regularity and a general sense of feeling good, the reviews give no detailed effects. **What they complain about:** Nothing. The store summary says no reviewer mentions a complaint, bad aftertaste, clumping or side effects. The limit is that the feedback is brief and thin, and does not go into the effects of specific ingredients. **Taste, smell and form:** Taste is the most praised point. Buyers describe a light berry flavor that is smooth, with "no grassy texture or taste." Another calls it "surprisingly tasty." Mixing also gets praise: it blends "really well with smoothies or just in a shaker," and another reviewer says it "mixes well." The reviews come from people who chose the berry flavor. The store page notes there is no feedback on the Citrus or Original flavors. Nobody comments on smell or on pill size, which does not apply to a powder. **Value for money:** Only one buyer speaks to price, saying the pricing "is on point." That is a single remark, so there is little to go on beyond it. **Who it seems to suit:** It looks like a fit for people who want an easy morning routine, whether stirred into a shaker or blended into a smoothie. Buyers who dislike grassy greens powders may like the berry flavor. Existing NutraBio customers also seem pleased to have a greens product from the brand; one says they had wanted one "for a while now." One buyer pairs it with another supplement and sees it as part of a daily stack. **Who it did not suit:** no reviewer reports that it did not work for them. Since the sample is small, with the store page citing twelve ratings and five written comments, a lack of negatives is not proof that none exist. **Left out:** Where store pages carried reviews of other forms of this product, those were not used here. This summary covers the powder only. **Bottom line:** Based on what is written, this is a pleasant-tasting, easy-mixing greens powder that buyers like for morning use and regularity. Treat the praise with some caution, given how few and how short the written reviews are.
Biohacker Summary
Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it
Tart cherry is the main ingredient, and seven of the ten panelists spoke about it, with five recommending it, one using it, and two staying neutral. Most take it for sleep, mentioning its natural melatonin, and several also point to muscle soreness, exercise recovery, and lowering uric acid. The only preparation named is tart cherry juice, with one panelist citing two glasses a day for two weeks, and another mentions a tart cherry extract in a sleep blend. No one reported stopping tart cherry or raised a caution about it. Vitamin C, potassium and iron are smaller ingredients in this product, and the panel's views on iron are mixed, with one warning against iron supplements and another who stopped because it did not raise his levels.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Tart Cherry · recommends
- Recommends tart cherry juice concentrate to lower uric acid by inhibiting xanthine oxidase, and also notes its melatonin content aids sleep, which indirectly helps insulin resistance.
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
- Recommends giving any iron intervention a couple of months before deciding if it works, and suggests increasing heme iron through red meat or liver intake.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Recommends tart cherry juice as one of the few higher fructose options that can work in the evening because its quercetin inhibits the enzyme that produces uric acid, and it's a dietary source of melatonin.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Compares iron content in spinach (2.7mg) and beef (2.6mg), but emphasizes that beef's heme iron absorbs at about 25%, while spinach's non-heme iron absorbs at 2-8%.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
Dave Asprey · Tart Cherry · recommends
- Mentions tart cherry extract as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Explains that potassium helps open a gate, allowing creatine to slip through and cross the blood-brain barrier more effectively.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Emphasizes the importance of having enough copper before trying advanced longevity strategies like peptides.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Mentions tart cherry extract as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Dave Asprey mentions that he will discuss copper in the episode.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- Warns that if a doctor diagnoses anemia, one should not assume they just need more iron, as low hemoglobin doesn't always mean low iron and the issue can sometimes be how well the body is using iron.
Siim Land · Tart Cherry · recommends
- States that tart cherry juice can help you sleep better, citing a randomized controlled trial where two glasses per day for two weeks reduced time spent awake during the night by 17 minutes and significantly improved insomnia severity.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Mentions that iron is a mineral necessary for making collagen.
- Mentions that copper is a mineral necessary for making collagen.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists potatoes and fruit as sources of Potassium.
- Lists dairy and sardines as sources of Calcium.
- Notes that Vitamin C is one of several supplements with human evidence.
- States that excess iron promotes oxidative stress and inflammation, which increases heart disease risk.
- States that tart cherry juice improved sleep and insomnia in older adults with insomnia when consumed twice a day for 2 weeks.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that bananas have potassium but there are at least 8 other foods with more potassium than bananas.
- States that potassium is the most abundant intracellular cation that helps to maintain intracellular fluid volume and that without it, one greatly increases the risk of hypertension, cardiovascular disease, diabetes, and stroke.
Dr. Rhonda Patrick · Tart Cherry · neutral
- Lists tart cherry juice as a supplement for enhancing exercise performance and recovery.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Recently found out he needed to get on an iron supplement and noticed he gets less sore in his training after taking it.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Advises that menstruating women should ensure they are getting enough iron.
- Notes that ~35% of Americans are low in vitamin C.
- Notes additional gaps in calcium.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
Ben Greenfield · Tart Cherry · uses
- Notes that Kill Switch contains tart cherry, an all-natural source of melatonin.
- Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Says Formula IQ CopperIQ Serum has stayed in their routine to close out summer strong.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends testing for and replenishing iron if levels are low, as it can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- Explains that copper plays a role in helping the body use iron properly, mobilizing iron, supporting red blood cell formation, and playing an important role in oxygen delivery throughout the body.
- Notes that one can eat iron-rich foods or supplement with iron, but still feel exhausted if iron is not the missing piece, emphasizing that focusing on a single mineral in isolation can support a number on a lab test rather than the system itself.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
Andrew Huberman · Tart Cherry · recommends
- Recommends tart cherry juice as effective for muscle injury and soreness, and also notes its potential benefit for aiding with sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- States that Iron is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes a multivitamin every day for longevity.
- Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Mentions potassium as an electrolyte.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, drinking it first thing in the morning and during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure he is hydrated and has sufficient electrolytes. He drinks it first thing in the morning and during physical exercise, especially on hot days.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium but no sugar, to ensure adequate hydration and electrolytes, especially when waking up and during exercise.
- Warns that excess iron will increase the number of senescent cells in the body, which accumulate as people get older and cause inflammation and cancer. He notes that people who are healthy and have a fairly vegetarian diet often have slightly low iron levels but super amounts of energy.
- Uses LMNT, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes for brain and body function, especially when starting his day fast or during physical exercise.
- Uses Element, which contains potassium, for proper hydration and electrolyte balance.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
Dr. Eric Berg · Tart Cherry · neutral
- Mentions tart cherry as a common remedy for gout that can inhibit the enzyme that makes uric acid.
- States that one can of sardines contains 382 mg of calcium.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Warns against iron supplements, suggesting instead to get iron from red meat or liver.
- Dr. Berg states that when nutrients like iron are too low, fatigue and weakness can follow.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Recommends potassium as an important electrolyte, noting that most people get less than half of the 4700 mg RDA.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Does not recommend taking iron supplements or cooking in iron skillets because the body has no mechanism of getting rid of iron unless one donates blood or is a menstruating female.
- Warns against calcium carbonate, calling it limestone and the worst source of calcium, stating it takes 12 steps to be converted in the body and is like eating rocks.
- Identifies iron as the Achilles' heel of cancer, as it is needed for its DNA to replicate.
- States that people need more potassium than any other mineral, yet most people aren’t getting enough.
- Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
Dr. Mark Hyman · Iron · neutral
- States that iron helps red blood cells carry oxygen, and a deficiency can make one feel like they are running on low power mode.
- Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Notes that a woman patient had very low iron.
- States that they get the whole picture when it comes to iron, looking at ferritin, iron reserves, iron in the blood, iron saturation, and iron binding capacity to spot problems before full-blown anemia.
- States that potassium plays a critical role in nerve signaling and muscle contraction, especially in the heart, and low levels can lead to dangerous irregular heart rhythms.
Peter Attia · Potassium · recommends
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Recommends iron supplements for women of reproductive age who are iron deficient.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as iron, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Delves into the crucial yet often overlooked topic of iron and iron deficiency.
- Explains that humans consume about 10 to 20 milligrams of iron per day, absorbing roughly 10% of that, which is 1 to 2 milligrams per day, perfectly offsetting the 1 to 2 milligrams lost daily.
Bryan Johnson · Iron · stopped
- Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
- Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
- Takes 2 mg of Copper in the morning for longevity.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 10 milligrams of heme iron to get his iron levels up, as they are borderline.
- Takes 250 milligrams of Vitamin C.
- Recommends adequate Iron for hair health, noting it is in the Blueprint stack.
- Bryan uses a copper pillowcase as part of his curated sleep environment.
- Recommends calcium at 1,200 mg daily for women during the follicular phase, depending on dietary intake.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
RAL Summary
Members OnlyTier 4 for Energy
The mushroom blend and tart cherry have some mixed human support for energy and exercise capacity [4][1]. With only 42 reviews, there are too few to confirm this, so it stays at the emerging tier.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 51 of the 131 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Muscular system, Digestive system, Nervous system, Cardiovascular system
Combine with: For liver support, pair this greens powder with ingredients that have stronger evidence. Milk thistle (silymarin, 150-300 mg standardized extract) supports hepatocyte protection. N-acetylcysteine (600 mg) boosts glutathione, the liver's main antioxidant. Phosphatidylcholine or choline helps fat metabolism and may reduce hepatic fat accumulation. Alpha-lipoic acid and TUDCA support bile flow and cellular protection. Taurine and omega-3 fish oil may help with fatty liver. For general nutrition, vitamin D, magnesium, and B-complex vitamins complement a greens powder. Avoid alcohol, and consult a healthcare provider if you have liver disease or take medications.
Possible side effects: In one study of men with Gulf War Illness, higher-dose Reishi made symptoms worse. No side effects were reported in the reviews.
Supplement Facts
Includes 0 g Added Sugars 0 · Vitamin C 44 mg · Calcium 30 mg
Supplement Facts
Serving Size 1 Scoop (11.43 g)
Servings Per Container 30
Amount Per Serving% Daily Value
| Calories | 35 | |
| Total Carbohydrate | 7 g | |
| Dietary Fiber | 4 g | |
| Total Sugars | 1 g | |
| Includes 0 g Added Sugars | ||
| Protein | 1 g | |
| Vitamin C | 44 mg | |
| Calcium | 30 mg | |
| Iron | 1.7 mg | |
| Copper | 2 mg | |
| Potassium | 100 mg | |
| Green Balance Alkalizing Blend® | 4 g | † |
| Chicory Root Fiber | 2 g | † |
| BettaBerries® Antioxidant Blend | 1.5 g | † |
| Adaptogen Mushroom Blend | 1 g | † |
| CherryPURE® Montmorency Tart Cherry Powder | 500 mg | † |
| DigeZyme® Multi-Enzyme Complex | 100 mg | † |
| Sodium Copper Chlorophyllin | 50 mg |
† Daily Value not established.
Other ingredients: L-malic acid 1.2 g, natural flavors 795 mg, steviol glycosides (stevia leaf extract) 280 mg.
Directions: Suggested Use: Mix 1 serving (1 scoop) with 8–12 oz of water or juice and consume 1–2 times daily. Alternatively, add 1 serving to a smoothie, stir into yogurt, or blend into your own shake to jump-start your day.
Barcode (UPC) 649908800079 · Label source: Reverseagelab · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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