Nutricost Berberine Review
Nutricost Berberine Capsules provide 600mg of Berberine HCl in every capsule, with 60 vegetarian capsules per bottle. The product is listed as vegetarian friendly, non-GMO and gluten free. Nutricost states that the product is third-party tested by ISO-accredited laboratories and made in a GMP compliant, FDA registered facility. The page lists the product under Herbs and Botanicals within the store catalogue, and it is offered with a 60-day money back guarantee on all orders. Nutricost says its products are made in the USA using globally sourced ingredients in a GMP-compliant facility, and that an independent, accredited lab tests products to help verify that what is on the label is what is in the bottle. The store describes its approach as focusing on quality ingredients, clear labeling and prices that make sense, without unnecessary fillers. The page shows a regular price of $20.97 and notes that HSA and FSA funds may be used by qualified customers. Free continental U.S. shipping applies to orders above $59, and the page gives an estimated delivery window. Returns are accepted within 60 days of the order date, items after the first bottle must be in new condition, and clearance items are not eligible. Customers can contact support by phone or email, using the details printed on the page, with questions about products or service.
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Lowest cost per month first, in stock, at 2 capsules a day. Checked Nov 9.
- VitacostLowest$15.72 a bottle$15.72/moBuy at Vitacost (opens in a new tab)
- Target$19.99 a bottle$19.99/moBuy at Target (opens in a new tab)
- Walgreens$54.99 a bottle$54.99/moBuy at Walgreens (opens in a new tab)
Study, Trial or Testing Result Summary
Members OnlyHuman studies
This product contains berberine hydrochloride from Indian barberry bark at 1200 milligrams per serving, and nothing else of note besides capsule and filler ingredients. For the heart and blood sugar goal, no study findings on berberine were provided to us, and the record notes that no human studies on this goal were found for its ingredients. Because of that, we cannot tell members what research shows about berberine and blood sugar, blood fats, or heart health from the information we have. We are not saying it does not work. We are saying the evidence in front of us is missing, so any benefit is unconfirmed here. Buyer feedback is largely positive by star count, but no written reviews could actually be read for this record, and a separate review summary gives different numbers, so buyer reports should be treated with caution. Anyone taking blood sugar medicine should talk with a doctor before adding berberine, since combining products that may affect blood sugar deserves care. We will update this summary when study findings for this goal are added. Animal and cell studies are never counted.
Review Totals and Summary
Members Only2,572 reviews · 90% positive
Nutricost Berberine has garnered significant positive attention from customers, with approximately 2572 ratings across various stores. The product enjoys a high level of satisfaction, with 73% of reviewers giving it 4 or 5 stars. **Positive Effects** Many users report significant benefits, particularly concerning blood sugar management. Customers noted it "helped lower my blood sugar" and kept it "at a steady 80." Some experienced improved "blood test results" and found it effective for "managing my blood sugar and cravings." Beyond blood sugar, several users reported weight loss, with one stating, "I am losing weight." Appetite control was another frequently mentioned benefit, described as a "great product for appetite control" and leading to "reduced cravings and better appetite control." The combination with Ceylon Cinnamon was also highlighted for "metabolic support!" and maintaining stable energy. **Concerns and Side Effects** While many find the product beneficial, some users experienced negative effects or found it unsuitable. A few reported that it "did not work for me at all." One user noted an increase in appetite and weight gain, stating, "have gained 5lbs. increased my appetite." Digestive issues were also mentioned, with one individual finding it "too strong" for their "delicate intestines," leading to an inability to use it. Another reviewer reported, "Made me throw up - berberine not for me." **Pill Form and Taste** The physical attributes of the supplement generally receive positive feedback. Many reviewers found the "pill size is easy to take" and described the "capsules are an easy size to swallow." Regarding taste, experiences varied; some reported "no taste," while others mentioned a "bad taste" or "no bad aftertaste either." The inclusion of Ceylon Cinnamon was often praised, with comments like "The cinnamon gives it a good taste" and appreciation for the "very good combination of berberine and cinnamon!" The ingredients are frequently described as "clean, of high quality" and "straightforward." **Value and Quality** Customers generally perceive Nutricost Berberine as a high-quality product. Reviewers consistently praise its "Good quality" and "Great Quality and Ingredients." The product is noted for its "3rd party testing," which adds to its credibility. While one reviewer mentioned the "bottle only lasts about two months" if taken regularly, another found it a "convenient size for more than 2 months." Indirectly, one user noted it was "saving me money" by reducing the need for other medications. **Suitability** This supplement appears particularly well-suited for individuals seeking support for blood sugar management, including those with diabetes, with one user noting it was "recommended by my D.O." It also seems beneficial for those aiming for appetite control, weight management, and overall metabolic support. The combination with Ceylon Cinnamon is a key draw for many. However, it may not be suitable for everyone, especially those with sensitive digestive systems or who experience adverse reactions like nausea, increased appetite, or weight gain. As one reviewer noted, "Each person is different."
Biohacker Summary
Members Only6 of 10 recommend it
Berberine is the only ingredient in this product, yet the panel's statements label it a smaller ingredient in this product, and nine of the ten panelists spoke about it. Most of the panel recommends or uses it, mainly for blood sugar and insulin resistance, with others citing cholesterol, cravings, sleep, and gut health. Two of them take 500 mg with meals, one mentioned 500 mg three times a day with meals, and some prefer a more absorbable form called dihydroberberine or a specially designed form. One panelist warned that taking it on an empty stomach can cause low blood sugar, headaches, dizziness, and vision trouble, and advised talking to a doctor first, while another urged caution when combining it with other glucose lowering meds. One panelist stopped using it after he no longer needed it for cheat days, and another said he skips it because of headaches and carb cravings.
See all 9 biohackers →Hide the biohackers
Thomas DeLauer · Berberine · recommends
- Recommends berberine as a metabolic reset, driving up AMPK to improve insulin sensitivity and dialing down fat and fructose processing in the liver that increases uric acid.
- Mentions dihydroberberine as a component that can be used to optimize and support the AMPK pathway, helping to tune it up and have a higher baseline.
- Has found berberine to be very helpful for some of his patients who are night snackers, especially those with a sweet tooth.
- Recommends berberine if one is going to have fruit later in the day, as it specifically restores the AMPK-driven fat suppression.
- Recommends Dihydroberberine to improve mitochondrial performance and turn up the AMPK dial.
- Recommends Berberine, stating that 500mg taken three times with meals has shown comparable results to a med in dropping HbA1c and fasting glucose.
- Would start taking berberine because it helps with high glucose.
- Mentions dihydroberberine or berberine as a powerful tool to upregulate activity, especially in the context of optimizing pathways to support key areas of change like hormone health.
- Likes berberine for people who are insulin resistant, noting it helps lower blood glucose spikes when taken with meals. He cautions against taking it on an empty stomach due to potential nausea or hypoglycemia.
- Recommends berberine in occasional doses for general blood sugar regulation, noting it activates AMPK, similar to a med, triggering glucose clearing, and has shown efficacy in reducing HbA1c and improving gut microbiome for glucose uptake.
Dr. Eric Berg · Berberine · recommends
- Recommends adding berberine as another natural remedy to the combination for cancer.
- Dr. Eric Berg states that Berberine combined with a lower-carb diet may help support healthy blood sugar levels and reduce cravings over time.
- Notes that some people add berberine, which supports healthy blood glucose and makes one insulin resistant.
- Recommends taking berberine to block the effects of grains.
- Suggests incorporating anti-cancer foods like berberine to help prevent pancreatic cancer.
- Recommends taking berberine, stating it is very beneficial for type 2 diabetes.
- Dr. Eric Berg states that berberine may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
- Lists berberine as an epigenetic factor that may help with cancer prevention.
- Recommends berberine as a natural version of a med, citing powerful research that shows it makes the body more sensitive to insulin and has fewer side effects than a med.
- Berberine is often compared to a med because of its potential effects on blood sugar and insulin resistance. More than 50 clinical trials have investigated berberine, with studies reporting improvements in A1C, fasting blood sugar, triglycerides, and LDL cholesterol comparable to those seen with a med.
Siim Land · Berberine · recommends
- Recommends berberine as a herbal supplement that increases fat metabolism, lowers mTor and blood sugar, making it a good combination for increased autophagy, and notes that meta-analyses show it reduces blood sugar, promotes weight loss, and decreases cholesterol.
- Recommends Berberine for blood sugar and cholesterol, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Berberine as one of 15 supplements backed by human studies.
- Advises caution when using berberine with glycine, as it is a glucose-lowering medication.
- Is skeptical about most supplements, including berberine, because he doesn't see any evidence to back up their claims, which are often based on personal testimonials.
- Mentions berberine as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- He takes 500 mg of berberine with meals for blood sugar control.
- Would take berberine for pre-diabetes.
- Advises caution with berberine due to its antibacterial effects and potential to change the microbiome, especially if one doesn't have gut problems.
- States that berberine also showed a lifespan extension in their hands.
Dr. Rhonda Patrick · Berberine · neutral
- Notes that berberine is a promising compound for cardiovascular health, with potential benefits spanning lipid metabolism, artery health, and the gut microbiome.
- Notes that berberine lowers LDL cholesterol in randomized trials and is interested in its connection to ApoB, artery plaque, and the gut microbiome.
- Notes that berberine has been on their radar for glucose control for years, and a new study on a biooptimized form of berberine showed reductions in fasting glucose, improved glucose tolerance, and an increase in fasting.
- Recommends berberine for atherosclerosis, noting it has a more compelling evidence base, showing reduction in plaque formation and improvement in LDL, HbA1c, and glucose regulation.
- Recommends Berberine for optimizing blood glucose, noting that meta-analyses show it reduces fasting glucose and HbA1c in people with type 2 diabetes.
- Notes that Berberine may not have the same inhibitory effect on muscular hypertrophy and strength gains as a med, but there are currently no studies to support or refute this.
- Discusses ideal dosing for berberine.
- Notes that berberine is also effective for blood glucose regulation, similar to apple cider vinegar.
- States that berberine is undoubtedly effective for improving insulin sensitivity.
- Discusses berberine, noting it is a mitochondrial toxin and an analog of a med, and mentions a systematic review suggesting it was beneficial in lowering LDL cholesterol and reducing a med myopathy.
Dave Asprey · Berberine · recommends
- Recommends berberine as a good alternative to a med for longevity, citing its similar pathway effects without the downsides and its positive impact on the microbiome.
- Dave Asprey discusses berberine as a plant compound that genuinely lowers blood glucose, comparable to a med in some trials, but notes its poor absorption and lack of lifespan data, classifying it as a glucose drug, not a longevity drug.
- Notes that berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch.
- Prefers a med over berberine, stating there is more data for a med, though berberine might be useful for diabetics.
- Dave Asprey and his guests reveal how berberine can improve metabolism, regulate dopamine, and protect the brain, and can rival meds.
- Mentions that GL Perfect contains bioavailable berberine, which is 250 times more bioavailable than normal.
- Takes berberine when he eats carbs to help manage blood sugar levels.
- Notes that Intellx DNA provides information on what doses of berberine, such as two grams, were used in studies to improve blood sugars, emphasizing that a small amount won't have the same effect as a larger dose.
- Mentions needing 72 milligrams of Berberine as part of personalized supplements.
- States that berberine has anti-parasite qualities and he takes it nearly constantly, but warns that it is not without risk, as he experienced abnormally low heart rate and blood pressure on two occasions, which he attributes to berberine.
Dr. Mark Hyman · Berberine · uses
- Takes 500 mg of Berberine with meals for blood sugar control.
- Recommends berberine to help with insulin resistance.
- Mentions that berberine may be helpful for people with insulin resistance and that he uses it in his practice.
- Recommends taking berberine as a natural way to increase GLP-1.
- Used an herbal regimen that included berberine as part of a combination product to treat a patient's dysbiosis and yeast overgrowth.
- Mentions that berberine can affect certain genes.
- States that berberine helps with blood sugar regulation, insulin resistance, and cardiac health.
- Mentions berberine as one of many phytochemicals that influence the AMPK pathway and have similar benefits to a med.
- Recommends berberine as helpful for insulin resistance and regulating blood sugar.
- States that berberine has effects and they try it when dealing with tough, desperate patients.
Andrew Huberman · Berberine · uses
- Takes 500 mg of berberine with meals to help with blood glucose.
- Dr. Huberman states he will skip berberine because it gives him brutal headaches, makes him crave carbohydrates, and drops his blood sugar.
- Discusses berberine and other potent molecules for regulating blood glucose.
- Warns that berberine is a serious step and one should talk to their doctor about it, as taking it on an empty stomach can cause hypoglycemia, brutal headaches, dizziness, and impaired vision; however, when taken with a large, carbohydrate-rich meal, he felt fine on up to 750 mg or a gram.
- Mentions the use of fasting-related supplements, including berberine.
- Huberman warns that if you take berberine without ingesting carbohydrates, many people, including himself, experience a splitting headache due to becoming hypoglycemic, as it is a glucose clearing agent.
- States that berberine can further support fat loss and discusses its impact on insulin.
- Mentions berberine as a compound, derived from a plant, that is in growing use for reducing blood glucose and is very potent at doing so.
- Warns that berberine can decrease testosterone levels, and that people often take it for blood sugar or longevity without considering this side effect.
- Huberman does not take berberine because it gives him brutal headaches, which he attributes to its effect of lowering blood glucose.
Ben Greenfield · Berberine · recommends
- States that berberine is great for sleep, upregulating serotonin and dopamine, and that their bioavailable berberine product is taken by 75% of users for sleep, even though it was created for blood glucose management.
- Now uses berberine as a natural strategy instead of a med and as a natural insulin-sensitizer.
- Offers berberine as a natural alternative for better blood sugar control.
- Recommends berberine or dihydroberberine as a powerful insulin sensitizing agent and a good alternative to a med, noting its comparable hemoglobin A1c reductions in some type 2 diabetes trials.
- Berberine was mentioned in a study as a biofilm disruptor that can improve microbial access and affect outcomes in SIBO and methane-dominant cases.
- Uses Dihydroberberine as part of the Neuro Regenerate product to protect mitochondria, stabilize energy, and sustain cognitive output.
- Recommends Dihydroberberine as a powerful antioxidant in Neuro Regenerate to support mitochondria and fuel clean, crash-free mental energy.
- Mentions the report recommends taking 500 mg of berberine to address ETBF activity.
- Mentions berberine as something that can enhance fatty acid oxidation and white adipose to brown fat tissue conversion.
- Recommends the regular use of berberine to help nuke bacterial overgrowth in the gut for those with FODMAP sensitivity.
Peter Attia · Berberine · stopped
- Used to take berberine, which he called "poor man's a med," to buffer blood glucose and feel less sick after ingesting large amounts of calories on a cheat day, but stopped when he no longer followed the Slow Carb Diet.
- Uses berberine in clinical practice as a weak inhibitor of the enzyme PCSK9, which can help a subset of patients who overexpress PCSK9 and have high LDL cholesterol.
- Suggests Thorne as the brand for berberine when recommending it to patients.
- Uses berberine in clinical practice as a weak inhibitor of the enzyme PCSK9, which can help lower LDL cholesterol in a subset of people who overexpress PCSK9.
- Uses berberine in clinical practice because it is a weak inhibitor of the enzyme PCSK9, which degrades LDL receptors. He finds it effective for a subset of patients who overexpress PCSK9 and have high LDL, and he will prescribe it to see if it helps without prior testing.
- Shares insights about berberine.
- Used to take Berberine for longevity but stopped because he didn't see enough evidence.
RAL Summary
Members OnlyTier 4 for Blood Sugar
Tier 3 needs some study support, but no ingredient findings were given and the record states there are no human studies on this goal for its ingredients, so only thin evidence remains and tier 4 applies. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
- No human studies on this goal for its ingredients.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Cardiovascular system, Digestive system
Combine with: To enhance the blood sugar regulating effects of Berberine, consider combining it with supplements like Alpha-lipoic acid (ALA), which can improve insulin sensitivity and reduce oxidative stress. Chromium is another excellent addition, as it plays a crucial role in carbohydrate and lipid metabolism, helping insulin work more effectively. Magnesium is also beneficial, as it's involved in over 300 enzymatic reactions, including glucose metabolism. Additionally, incorporating a soluble fiber supplement or increasing dietary fiber intake can help slow glucose absorption and further support healthy blood sugar levels.
Possible side effects: No study side effects were given; the review summary mentions one buyer reporting raised blood pressure with chest pain and another reporting increased appetite and weight gain, though these comments may not be about this exact product.
Supplement Facts
Berberine HCI 1200 mg
| Berberine HCI (Berberis aristata)(bark) | 1,200 mg | † |
Other ingredients: Rice flour, hypromellose (cellulose) capsule, silica, olive oil, magnesium stearate (vegetable source), microcrystalline cellulose.
Directions: As a dietary supplement, take 2 capsules daily with 8-12 oz of water or as directed by your healthcare professional.
Label source: Vitacost · Report a label change
Sizes and barcodes: 60 Capsules, UPC 8 10139 57287 9 (on market)
Show entire label
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Our articles on this subject
- How to Lower Blood Sugar Naturally: A Comprehensive GuideArticle · Sep 9, 2026
- Intermittent Fasting: What the Human Trials Show for Weight, Blood Sugar and AgingArticle · Oct 29, 2026
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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