Nutricost Betaine Anhydrous 1500 mg Capsules Review
This Nutricost listing on Amazon is for Betaine Anhydrous in capsule form. Each bottle contains 120 capsules, which the page describes as 60 servings. Each capsule holds 750mg of Betaine Anhydrous, so one serving provides 1500mg. The page states the product is third-party tested by ISO-accredited laboratories, is non-GMO, gluten free and soy free, and is made in a GMP compliant, FDA registered facility. The item details list the brand as Nutricost, the primary supplement type as Betaine Anhydrous, the item form as capsule, the unit count as 120 count, the container type as bottle, and the flavor as unflavored. The listing shows an item weight of 4.9 ounces and dimensions of 2.4 x 1.81 x 4.53 inches. The page lists the product as sold by eSupplements and shipped by Amazon, with a one-time price of $10.00 and a Subscribe and Save option at $9.00. The page also notes that the item is non-returnable due to food safety reasons. The page does not provide a full ingredients list or written customer reviews in the text provided.
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Study, Trial or Testing Result Summary
Members Only10 human studies · 6 improved
Betaine taken on its own has not helped liver health in the better studies. A pooled analysis of trials found betaine did not change liver enzymes or inflammation, and it raised total and bad cholesterol [1]. In a placebo-controlled trial of 55 people with fatty liver inflammation, 20 grams a day for 12 months did not improve liver fat, disease activity or scarring on biopsy [2]. In 27 obese adults with prediabetes, 9.9 grams a day for 12 weeks did not change liver fat and raised total cholesterol [3]. The positive results come mostly from products that mixed betaine with other ingredients. A betaine combination cut liver fat by 25% over 8 weeks in 191 people [4], and a nutrient mix containing betaine lowered liver fat score by 4% in 155 adults [5]. A study without a placebo group in 70 people found 2 to 8 grams a day lowered liver enzymes, while 1 gram did not [6]. This product gives 1500 milligrams per serving, or 3 grams at two servings a day, which is within the range of that uncontrolled study but far below the doses that failed in the placebo-controlled trials. Animal and cell studies are never counted.
See all 10 studies →Hide the studies
- A pooled analysis of trials found betaine supplementation did not change liver enzymes (ALT, AST, GGT) or inflammation (CRP), though it raised total and LDL cholesterol.Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis.
- In 191 people with fatty liver inflammation, 8 weeks of a betaine glucuronate combination cut liver fat by 25% and lowered liver enzymes, while placebo did not.Efficacy and safety of oral betaine glucuronate in non-alcoholic steatohepatitis. A double-blind, randomized, parallel-g…
- In 155 adults with obesity and metabolic syndrome, 3 months of a nutrient mix containing betaine lowered liver fat score by 4% and liver stiffness by 7.8% versus placebo.Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults wi…
- In 55 people with biopsy-proven fatty liver inflammation, 20 g of betaine daily for 12 months did not improve liver fat, activity score or fibrosis compared with placebo.Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial.
- In 27 obese adults with prediabetes, 9.9 g of betaine daily for 12 weeks did not change liver fat compared with placebo and raised total cholesterol.Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.
- In 20 people with fatty liver inflammation, 2 weeks of a multi-ingredient food containing betaine plus diet lowered liver enzymes and body fat, while diet alone did not significantly.[Efficacy of newly developed food for special dietary use in the diet of patients with non-alcoholic steatohepatitis].
- In 41 children with chronic hepatitis B in leukemia remission, adding betaine arginine to standard care left ALT 1.6 times lower and reduced a fibrosis marker versus standard care alone.MODERN APPROACHES IN MANAGEMENT OF CHILDREN WITH CHRONIC HEPATITIS B IN REMISSION OF ACUTE LYMPHOBLASTIC LEUKEMIA.
- In a non-placebo-controlled trial in people with liver disease linked to short bowel syndrome, 10 grams of betaine daily for three months reduced liver fat on MRI, but blood markers of inflammation and liver damage did not significantly improve, and diarrhea and nausea were common.Betaine: a potential agent for the treatment of hepatopathy associated with short bowel syndrome.
- In 70 people with fatty liver disease and high ALT, betaine at 2, 4 or 8 g a day for 12 to 24 weeks lowered liver enzymes and other liver injury markers, but 1 g a day did not.Pilot trials of oral betaine in participants with metabolic dysfunction-associated steatotic liver disease and elevated …
- In 10 adults with NASH, betaine taken for up to 12 months improved liver enzymes and liver biopsy scores in an uncontrolled pilot study, with mild stomach side effects in four patients.Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study.
Review Totals and Summary
Members Only1,193 reviews · 90% positive
Nutricost Betaine Anhydrous 1500 mg Capsules generally receives positive feedback, with 78% of its approximately 1193 ratings across various stores giving it 4 or 5 stars. Customers often highlight its effectiveness for various health goals and its good value. **What it did for buyers** Many customers report noticeable benefits from taking these capsules. A significant number mention improvements in blood pressure, with some stating, "my BP was down WoW!" and "Worked for lowering my BP." Others found it beneficial for digestion, noting it helped "with digestion" and made them feel "less bloated and much more comfortable." For those focused on fitness, the supplement is praised for enhancing workout performance, supporting "strength, endurance, and workout performance," and helping with "recovery and circulation." Some users also incorporate it into their daily routine for general well-being, reporting that it "supports overall health." A few buyers also found it to be as effective as, or even "better than, other brands." **Complaints** While most feedback is positive, some users did not experience the desired effects. A few customers reported, "Cannot tell if it does anything," or felt it "Doesn't seem as effective as other brands." A small number of individuals also experienced adverse reactions, with one reviewer stating it "Caused stomach problems." Store summaries indicate that despite limited written complaints, a portion of overall ratings are one star, suggesting some dissatisfaction not detailed in visible reviews. **Pill Attributes** The capsules are generally well-received for their physical characteristics. Many reviewers describe them as "small and easy to swallow" or "easy to take and not too big." Regarding taste, feedback is mostly positive or neutral; customers say the capsules are "tasteless," have "no bad taste," or even a "pleasant taste." The product's packaging also receives praise, with reviewers noting it "arrived fresh and was very well packaged." **Value for Money** Customers frequently commend the product for its affordability and quality. Many consider it "cheap enough" and a "good quantity for the price." Reviewers often describe it as having a "competitive price" and offering "Best value for your buck," indicating satisfaction with the cost-effectiveness of the supplement. **Suitability** This product appears to suit individuals seeking support for blood pressure management, digestive comfort, and enhanced athletic performance, particularly those looking for an easy-to-take capsule form. It is also favored by those who prioritize good value and quality in their supplements. However, it may not be suitable for everyone, as some users reported no noticeable effects or experienced stomach discomfort.
Biohacker Summary
Members Only7 of 10 recommend it
Seven of the eight panelists who spoke about betaine, the main ingredient, recommend or use it, and the other two lean neutral. The biggest reason is digestion: four of them take the hydrochloride form with meals to raise stomach acid, to ease bloating, heartburn and poor protein absorption, with one suggesting several pills before a meal and another one pill per meal, three a day. Others take it, also called trimethylglycine, to support methylation and liver function, to help with insulin sensitivity and fat burning, and for exercise power, and one suggests 1 to 3 grams a day for people who do not respond to creatine. Doses of 2000 to 3000 milligrams a day were mentioned for poor methylators, while another said at least 4 grams a day over six weeks was needed to lower homocysteine, and one prefers getting it from foods like beets and spinach. The one caution is to avoid the hydrochloride form with a stomach ulcer, and one panelist pairs it with digestive enzymes and with meds that cut stomach acid.
See all 8 biohackers →Hide the biohackers
Dr. Eric Berg · Betaine · uses
- States he added 500 mg of betaine to his creatine product because it helps the body make more creatine.
- Recommends betaine hydrochloride for constant bloating and gas, especially if it's due to low stomach acid.
- Recommends taking betaine hydrochloride if an antacid was taken.
- Recommends betaine hydrochloride for heartburn or indigestion, stating it increases stomach acidification and can be taken in multiple pills before a meal.
- States that Betaine hydrochloride can help to restore stomach acid, but warns it should be avoided if one has a stomach ulcer.
- Betaine hydrochloride is an amino acid found naturally in foods, including beets, spinach, beef, and shrimp. It's an excellent natural remedy for increasing stomach acid. Dr. Eric Berg recommends consuming either betaine hydrochloride or apple cider vinegar before each meal.
- Recommends Betaine hydrochloride for heartburn and indigestion, stating it helps acidify the stomach and keep the valve at the top of the stomach closed.
- Suggests that increasing stomach acid with things like betaine hydrochloride could be a solution for acid reflux.
- States that Betaine hydrochloride can help to restore stomach acid, but warns it should be avoided if one has a stomach ulcer.
- Recommends betaine hydrochloride as one of the best ways to re-acidify the stomach, but warns against its use if one has gastritis or an ulcer.
Thomas DeLauer · Betaine · recommends
- Would start taking trimethylglycine (TMG), also known as betaine, due to increasing evidence of its benefits for insulin resistance and its ability to increase fat oxidation.
- Recommends TMG (trimethylglycine or betaine) for improving body composition and insulin sensitivity, and for supporting methylation pathways that keep the endothelium healthy, complementing the shear stress benefits of walking.
- Recommends TMG, also known as betaine, to aid the liver's ability to clear excess cortisol from the system.
- Highlights trimethylglycine (betaine) from beets as a powerful methyl donor that helps the liver break down homocysteine, takes the load off the liver, and is required for carnitine creation, which is crucial for fat burning and addressing fatty liver.
- Highly recommends TMG (trimethlycine or betaine), found in beets or as a supplement, because it's a methyl donor that aids in methylation in the liver, which is required for bile acid synthesis and phase 2 detoxification.
- Cycles TMG (trimethylglycine or betaine) on and off, doing four weeks on and four weeks off, because it helps lower the toxic load on the body, aids in methylation, improves insulin signaling, mitochondrial function, brain function, and has been shown to reduce hepatic triglycerides, liver fat, and increase muscle mass while decreasing fat mass.
- Recommends two to four grams of trimethylglycine (TMG or betaine) to help take a lot of stress off the liver.
- Recommends 3-4 grams of trimethylglycine (betaine) to help regulate homocysteine, which allows the body to deal with insulin resistance better.
- Recommends TMG (trimethylglycine or betaine) as a compound that works well with walking at a cellular level to detoxify the system, amplify energy production and fat loss, and course correct insulin resistance. He suggests a dose of 1.5 to 6 grams per day.
- Recommends TMG (trimethylglycine or betaine) for fat loss and muscle growth, citing studies that show it can prevent the formation of white adipose tissue, increase mitochondrial biogenesis, improve insulin resistance, and reduce total fat mass while increasing or maintaining lean body mass. He suggests taking it pre-workout to induce more fat burning and prevent fat accumulation later in the day.
Dave Asprey · Betaine · recommends
- Recommends taking betaine HCL (stomach acid) with meals to improve protein absorption, as stomach acid decreases with age.
- Takes stomach acid, betaine HCL, and enzymes to help digest food, which he says speeds healing and resilience.
- States that if you take Pepsid, you have to take betaine and enzymes to counteract the digestion-ruining effects, and also suggests taking a little betaine with a meal to help with nutrient absorption.
- Recommends always taking Betaine HCL, which is stomach acid, with food when taking Pepcid AC for long COVID protocols, as it's necessary for the Pepcid to work effectively.
- Recommends taking betaine HCL religiously with every meal during protocols that block histamine response to prevent gut problems from lack of stomach acid.
- Increased his Betaine HCL intake to address low stomach acid, which he believes is necessary when eating a lot of steak.
- Recommends taking Betaine HCL to increase stomach acid if on a med, to help with delayed gastric emptying.
- Advises taking Betaine HCl because Pepcid, which he recommends, blocks stomach acid.
- Recommends taking betaine HCl with every meal when using Pepcid to artificially suppress stomach acid, to ensure food is still at the correct pH for digestion.
- Notes that betaine HCl, which increases stomach acid, is not suitable for everyone, especially younger individuals, and can sometimes make issues worse if neurogenic switching is caused by pathogens or toxicity.
Dr. Mark Hyman · Betaine · uses
- Uses Betaine HCl to provide stomach acid, which helps digest food and reduce SIBO.
- Suggests that betaine hydrochloride can be used to acidify the digestive system, helping to relieve digestive problems associated with chronic pancreatic insufficiency.
- Recommends betaine, found in beets, quinoa, spinach, and regeneratively raised beef and turkey, for supporting methylation.
- Recommends Betaine HCL to increase stomach acid and help with food digestion.
- Recommends replacing digestive enzymes or things like betaine HCl to help the body digest food and break down proteins, especially when the gut is inflamed, though they may not be needed once the gut has healed.
- Uses betaine HCl to support stomach acid in patients.
- Uses betaine in their clinic to address issues with protein digestion, particularly for individuals with a lack of stomach acid, after measuring their acid levels.
- Explains that methylation is regulated by important molecules like B6, B12, folate, betaine, and methionine, which are found in our diet.
- Uses Betaine HCl to increase stomach acid and help the body digest food more effectively.
- Recommends Betaine HCl to increase stomach acid, which helps the body digest food and makes it easier to absorb nutrients, reducing the likelihood of feeding dysbiotic bacteria.
Dr. Rhonda Patrick · Betaine · neutral
- Mentions betaine or trimethylglycine as something that may improve power output during exercise.
Ben Greenfield · Betaine · recommends
- Recommends taking trimethylglycine, also known as betaine, beforehand with NAD IVs to stave off gastric distress and sympathetic nervous system stimulation.
- Recommends betaine hydrochloride, three a day, one per meal, to help with digestion and nutrient absorption.
- Notes that combining blood flow restriction with a blood flow precursor like betaine results in significantly greater training benefits.
- Recommends Thorne ResveraCel as a good source of resveratrol, noting it combines resveratrol with nicotinamide riboside, quercetin, and betaine to support cellular function and methylation, which are affected by EMF.
- Recommends Thorne ResveraCel, which contains Resveratrol, quercetin, and betaine, for anti-aging and to combat free radicals that cause eye damage or glaucoma.
- Lists Betaine HCl digestive enzyme as a resource from the episode.
- Recommends supplementing with Betaine HCl with a protein-based meal to help break down protein, especially if one has an underactive stomach and is not producing enough stomach acid. He personally takes 8 capsules before heavy protein meals.
- Ben discusses Betaine HCL in the context of a listener experiencing insomnia, anxiety, and joint pain from it, and considers if it could be related to suppression of potassium and magnesium.
- Lists Betaine Hydrochloride supplements as a resource for healing the gut.
- Ben mentions Betaine HCL as a resource for caloric needs after an endurance event.
Siim Land · Betaine · recommends
- Recommends getting trimethylglycine (TMG), also known as betaine, from whole foods like beetroot, shrimps, spinach, wheat germ, wheat bran, mushrooms, and various vegetables to support DNA methylation.
- Recommends TMG (trimethylglycine or betaine) for longevity and DNA methylation, especially for poor methylators who might need up to 2000-3000 milligrams per day, while those with good methylation genes might not need to supplement if they eat TMG-rich foods.
- States that betaine, or trimethylglycine, has been shown to decrease plasma homocysteine levels, with supplementation of at least 4 grams a day for a minimum of six weeks being effective.
Andrew Huberman · Betaine · neutral
- Discusses betaine as a potential alternative for creatine non-responders, taken at 1 to 3 grams per day, which helps with amino acid synthesis and energy shunting.
- Mentions that there is some evidence that betaine, also called trimethylglycine, can improve lean mass and power output.
- Notes that many people who have difficulty adjusting their gut pH and microbiota have benefited from taking betaine HCL pepsin tablets or capsules during meals, starting with one or two and experimenting to find a comfortable level.
- Andrew Huberman recommends betaine for creatine non-responders, suggesting a dose of one to three grams per day to help with amino acid synthesis and shunting of energy.
- Huberman discusses betaine as a potential supplement for creatine non-responders or if homocysteine is persistently elevated, with a typical dosage of 1 to 3 grams per day.
RAL Summary
Members OnlyTier 5 for Liver Health
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Cardiovascular system
Combine with: To enhance the benefits of Betaine Anhydrous for liver health, consider combining it with B vitamins, particularly B6, B9 (folate), and B12, as these are crucial cofactors in the methylation pathways that Betaine Anhydrous supports. N-Acetyl Cysteine (NAC) is another excellent addition, as it's a precursor to glutathione, the body's master antioxidant, vital for liver detoxification. Milk Thistle (silymarin) is well-regarded for its hepatoprotective properties, supporting liver cell regeneration and protection. Additionally, Alpha-Lipoic Acid (ALA) can provide further antioxidant support, and Choline is essential for fat metabolism in the liver, preventing fat buildup.
Possible side effects: In studies, betaine raised total and bad cholesterol. No other major side effects were reported in the studies given.
Supplement Facts
Betaine Anhydrous 1500 mg
| Betaine Anhydrous (Trimethylglycine)(TMG) | 1,500 mg | † |
Other ingredients: Gelatin capsule, calcium silicate, magnesium stearate (vegetable source).
Directions: As a dietary supplement, take 2 capsules daily with 8-12 oz of water or as directed by your healthcare professional.
Label source: Vitacost · Report a label change
Sizes and barcodes: 120 CAPSULES, UPC 8 10139 57250 3 (on market)
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