Nutrilite Stress Relief Probiotic Review
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Study, Trial or Testing Result Summary
Members Only1 human studies · 0 improved
The research for this product is thin. Only one human study involved any of its ingredients for bloating and irregularity. In that well-run trial, 156 adults with bloating and constipation took either a placebo or a blend of five probiotic strains for two weeks. The blend included Lactobacillus paracasei Lpc-37, the main strain in this product, along with four other strains, at a total of 2.5 billion live bacteria a day [1]. The blend did not reduce bloating or the study's other main measures compared with the placebo [1]. A later look at the data, not planned at the start, suggested people taking the blend had less gas [1]. Because Lpc-37 was tested only as part of a mix, for a short time, in a single trial, we cannot say whether it helps or fails on its own. This label lists its strains by weight rather than by live bacteria count, so it is unclear whether it matches the studied amount. No human studies were found for the other strain, Bifidobacterium animalis lactis B420, or for the melon juice concentrate or superoxide dismutase for this goal. Animal and cell studies are never counted.
See all 1 studies →Hide the studies
- In 156 adults with bloating and constipation, a two-week five-strain probiotic blend including Lpc-37 did not reduce bloating or the other main outcomes compared with placebo, though a post-hoc analysis showed less flatulence.The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placeb…
Review Totals and Summary
Members Only877 reviews · 95% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Superoxide dismutase is the only ingredient here, and it is a smaller ingredient in this product. Seven of the ten panelists spoke about it, and only one of them says he personally uses it, mainly because his body makes little of its own, and he has also said he gets it from chlorella and through exosome delivery. The rest are neutral and describe it as an antioxidant enzyme the body makes that fights free radicals and weakens with age, with some noting that cold exposure and certain plant compounds raise it. One panelist adds that copper and zinc make up the enzyme. No one gave a dose, a preferred form beyond those sources, or a caution, and no one said they stopped using it.
See all 7 biohackers →Hide the biohackers
Dave Asprey · Superoxide Dismutase · neutral
- Dave and the Young Goose team explore superoxide dismutase as one of the most unusual compounds now being used in skin longevity, explaining how it may interact with oxidative stress.
- Mentions SOD (superoxide dismutase) as an antioxidant system that disarms the most aggressive free radical, but weakens with age and needs support.
Ben Greenfield · Superoxide Dismutase · uses
- Uses superoxide dismutase to defend against oxidative stress at the cellular level, delivered via Vampire Exosomes.
- Mentions superoxide dismutase as an endogenous antioxidant released when the body is exposed to mild stress.
- Personally supplements with superoxide dismutase because his body doesn't make a lot of it, which influences his endogenous antioxidant production.
- Mentions that DNA testing has shown he has very low levels of endogenous production of the antioxidant superoxide dismutase, which is why he prioritizes glutathione.
- Says he is getting superoxide dismutase from the chlorella.
Thomas DeLauer · Superoxide Dismutase · neutral
- Mentions superoxide dismutase as one of the body's two key inherent detoxification systems, responsible for neutralizing free radicals and helping to detoxify.
- Notes that bee pollen itself contains superoxide dismutase, making it a potent stimulator of antioxidants in the body and an antioxidant itself.
- Notes that Sacha Inchi oil in rats led to an increase in superoxide dismutase, a powerful antioxidant in the liver, suggesting it influences antioxidant production in the body.
- Discusses superoxide dismutase as a crucial endogenous antioxidant, noting that astaxanthin supplementation in rats restored its levels and increased its antioxidant capacity.
- Notes that a study on winter swimmers also found increases in superoxide dismutase, indicating upregulation of endogenous antioxidants from cold exposure.
- Mentions superoxide dismutase as an endogenous antioxidant expressed by FOXO3 that helps stave off the effects of aging.
- Notes that lemon juice may influence the body's own superoxide dismutase levels, which are inherent antioxidants that neutralize free radicals.
- Mentions that sitting in a sauna for 20 minutes increased superoxide dismutase, which is one of the most powerful internal antioxidants.
- States that grass-finished beef contains higher levels of superoxide dismutase, which, along with glutathione, helps kill off free radicals and supports the body's detoxing process.
- Thomas DeLauer notes that maca root acts as a natural antioxidant and boosts levels of SOD (superoxide dismutase), which is a major disease fighter in the body.
Dr. Mark Hyman · Superoxide Dismutase · neutral
- Notes that NRF2 activators lead to a massive production of superoxide dismutase as part of the body's antioxidant defense.
Siim Land · Superoxide Dismutase · neutral
- Mentions superoxide dismutase as part of the body's antioxidant defense system that helps counteract oxidative stress.
- Mentions that cold strengthens the immune system by increasing antioxidant defense systems such as superoxide dismutase.
Dr. Eric Berg · Superoxide Dismutase · neutral
- Explains that copper and zinc make up the enzyme SOD (superoxide dismutase), which is involved in longevity.
Dr. Rhonda Patrick · Superoxide Dismutase · neutral
- Dr. Patrick mentions superoxide dismutase as a natural antioxidant enzyme produced by the body.
- The activity of superoxide dismutase increased in supplemented participants' neutrophils, indicating enhanced neutrophil function.
- Dr. Rhonda Patrick states that our bodies naturally produce antioxidants such as superoxide dismutase.
RAL Summary
Members OnlyTier 4 for Gut Bacteria Balance
The ineffective grade rests on a single trial of a five-strain probiotic blend, not on Lactobacillus paracasei Lpc-37 alone, so it cannot show that this product does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 1 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Lactobacillus paracasei Lpc-37 105 mg · Bifidobacterium animalis lactis B420 15 mg · Extramel Melon Juice Concentrate 10 mg
| Lactobacillus paracasei Lpc-37 | 105 mg | † |
| Bifidobacterium animalis lactis B420 | 15 mg | † |
| Extramel Melon Juice Concentrate | 10 mg | † |
| Superoxide Dismutase | 140 IU | † |
Other ingredients: Maltodextrin, Hydroxypropyl Methylcellulose, Fructooligosaccharides, Chamomile Extract, Gum Arabic, Silicon Dioxide, Medium Chain Triglyceride, Sunflower Oil, Rice Bran Extract, Rice Husk.
Directions: 1 capsule, 1x a day Suggested use: Take 1 capsule per day, preferably with food.
Label source: NIH label database · Report a label change
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- Probiotics for Gut Health: The Complete GuideArticle · Mar 17, 2026
- Best Probiotic for Bloating: The Strains With Human Trials, and How to Choose OneArticle · Oct 27, 2026
Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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