ProCaps Laboratories Ultimate Whey Protein Isolate Review
Andrew Lessman ProCaps Ultimate Whey Protein Isolate is an unflavored whey protein isolate powder sold in a 120 serving container. The product is described as pure whey protein isolate with no added flavors, sugar or sweeteners, intended to support lean muscle and recovery. Not all protein is created equal, the listing says, and this product is thoughtfully formulated using premium whey protein isolate, delivering exceptionally pure, highly bioavailable protein without the unnecessary sugars, flavors, sweeteners or fillers commonly found in conventional protein powders. Whey protein isolate naturally provides the essential amino acids the body depends on to support lean muscle, exercise recovery and countless structural and metabolic functions. The listing states that because it is carefully refined, whey protein isolate contains less fat, fewer carbohydrates and significantly less lactose than many traditional whey protein products while maintaining outstanding protein quality. The powder can be mixed into water, blended into smoothies or added to recipes. The bullets state that the product is non GMO, fat-free, cholesterol-free and sugar-free, and that it is neutral-tasting and easy to mix. Directions say to mix one or more scoops with any beverage and note that it works with wellness or weight-loss plans when used as part of a healthy diet and active lifestyle, along with one of Andrew Lessman's multi-vitamin-mineral formulas. The seller states that ProCaps formulates, manufactures and quality tests every product in its Henderson, Nevada facility rather than relying on third-party manufacturers. Andrew Lessman has been making supplements since 1979, and the listing says the commitment to exceptional ingredients, thoughtful formulation and uncompromising manufacturing standards continues in every ProCaps product. Product details list a bottle package type, a unit count of 120 ounces, one item, dimensions of 4 x 4 x 14 inches and a weight of 2.56 pounds. The listing also states that this product is not a sole source of nutrition or a stand-alone weight loss product. Statements regarding dietary supplements have not been evaluated by the FDA and the product is not intended to diagnose, treat, cure, or prevent any disease or health condition. The page sells the item through the Andrew Lessman ProCaps Laboratories seller account, with non-returnable status due to food safety reasons, though damaged or defective items may be refunded or replaced.
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Study, Trial or Testing Result Summary
Members Only33 human studies · 14 improved
1 of these 33 human studies gave the ingredient by drip, not by mouth.
This is a whey protein isolate, but no studies on whey protein alone were provided, so its main ingredient cannot be judged here. The only related finding is a 10-week strength training trial in 26 young adults: a mixed supplement of whey protein, leucine, creatine, calcium and vitamin D added more lean mass than placebo, but the effect of each ingredient could not be separated [1]. A similar mixed supplement grew fast muscle fibers more than a collagen control [2]. The minerals on the label are present only in small amounts. Calcium, at 40 mg, did not build muscle in children, teenage girls or older adults [3][4][5][6]. Magnesium, at 6 mg, is far below the 250 to 300 mg used in trials. A pooled analysis of 14 trials found no meaningful strength gain [7], and 250 mg daily did not add strength or lean mass in overweight women [8]. Some small trials in people low in magnesium did show strength gains [9][10]. For phosphorus, at 20 mg, the evidence is unclear because there are too few studies [5]. Animal and cell studies are never counted.
See all 33 studies →Hide the studies
- Pooling 14 trials of 542 athletes, healthy adults, elderly people and alcoholics, magnesium did not significantly improve muscle strength, torque or power, though it may help people who are low in magnesium such as the elderly.The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review.
- Across seven trials of 349 older people with weak bones and low muscle, strength training raised muscle mass, grip strength and protein intake, but calcium intake did not change significantly.Effects of Strength Training on Body Composition, Physical Performance, and Protein or Calcium Intake in Older People wi…
- In a review of nine reviews covering 128 studies, calcium supplements had only modest effects on bone mineral content and no muscle benefit was reported for calcium itself, though cheese and yogurt were linked to better grip strength.Nutrients and food supplements for the prevention of musculoskeletal diseases: an umbrella review.
- In a review of 45 mostly cross-sectional studies in older adults, no link was found between calcium and muscle mass, strength, physical performance or sarcopenia.Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
- In 1434 children aged 6 to 9, two years of an after-school program with 380 mg daily calcium-rich snacks and exercise raised bone stiffness in one group but did not change muscle strength or vertical jump.Beat osteoporosis - nourish and exercise skeletons (BONES): a group randomized controlled trial in children.
- In 156 older women with low muscle mass, 1500 mg daily of calcium-HMB for 12 weeks did not add to the effects of resistance training on muscle quality compared with placebo.β-Hydroxy-β-Methylbutyrate Supplementation May Not Enhance Additional Effects of Exercise on Muscle Quality in Older Wom…
- In 148 men aged 70 and over with low testosterone, 20 weeks of calcium, vitamin D and protein with resistance training and testosterone improved chair stand performance versus no intervention, but calcium's own effect could not be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 105 older outpatients at risk of malnutrition, a nutrient-rich drink for 12 weeks raised calcium intake and increased muscle mass in women, but muscle strength and physical performance did not differ from standard care.The effect of 12-weeks Nutritional supplementation on Nutritional Intake and Status among Indonesian Older Outpatients w…
- In 98 adults over 50, drinking 1 liter a day of calcium and magnesium-rich mineral water for 12 months raised muscle mass relative to height and lowered falls at 6 months, but did not change physical performance scores.Efficacy of a Naturally Calcium and Magnesium-Rich Mineral Water on Musculoskeletal Fragility: A Randomized, Double-Blin…
- In 83 vitamin D-deficient middle-aged women, 250 mg magnesium daily plus weekly vitamin D for 8 weeks improved handgrip strength and walking-test time and lowered a blood inflammation marker, but did not change body composition or knee strength.Randomized Study of the Effects of Vitamin D and Magnesium Co-Supplementation on Muscle Strength and Function, Body Comp…
- In 74 middle-aged overweight women, 250 mg magnesium oxide daily for 8 weeks did not produce greater gains in muscle strength, function or lean mass than placebo.Does magnesium supplementation improve body composition and muscle strength in middle-aged overweight women? A double-bl…
- In 59 patients with alcoholic liver disease, 6 weeks of magnesium had no effect on muscle strength or mass compared with placebo, as both groups improved.Magnesium supplementation and muscle function in patients with alcoholic liver disease: a randomized, placebo-controlled…
- In 59 older adults averaging about 80 years, a combination supplement containing magnesium improved muscle mass, all muscle function tests and inflammation markers compared with placebo.A Patented Dietary Supplement (Hydroxy-Methyl-Butyrate, Carnosine, Magnesium, Butyrate, Lactoferrin) Is a Promising Ther…
- In 51 people with Parkinson's disease, magnesium was used as the comparison to whey protein for 4 weeks, and the two groups did not differ in changes in walking and movement tests.Can we add whey protein supplementation in patients with Parkinson's disease without interfering with levodopa response?
- In 49 chronic heavy-drinking adults, 6 weeks of oral magnesium raised muscle strength significantly while placebo produced no change.Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics.
- In 46 adults with moderate-to-severe lung disease (COPD), 8 weeks of a daily 250 ml whey drink fortified with magnesium and vitamin C increased muscle mass index, body protein and handgrip strength compared with the control group, and lowered an inflammation marker.Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized c…
- In 44 children and teens with cystic fibrosis, 300 mg of magnesium daily for 8 weeks improved breathing muscle strength much more than placebo in a crossover trial.Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-bli…
- In 43 malnourished people with liver cirrhosis, 3 g a day of calcium HMB for 12 weeks did not change fat-free mass compared with the supplement without it, though handgrip strength trended upward.Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplement…
- In 40 young men doing 8 weeks of resistance training, calcium HMB did not improve muscle thickness, strength or power more than placebo.Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness.
- In 40 resistance-trained young men over 8 weeks of training, calcium HMB did not reduce training-related inflammation or change muscle thickness or strength compared with placebo.Leucine metabolites do not attenuate training-induced inflammation in young resistance trained men.
- In 26 healthy young adults doing 10 weeks of resistance training, a supplement with whey protein, leucine, creatine, calcium citrate and vitamin D twice daily increased lean body mass more than placebo (+4.1 vs +2.8 kg), but calcium's own effect cannot be separated.The Effect of a Multi-ingredient Supplement on Resistance Training-induced Adaptations.
- Over 10 weeks of resistance training, a multi-ingredient supplement containing calcium citrate increased the size of fast muscle fibers more than a collagen control, though calcium's effect could not be separated from the other ingredients.The Effect of Multi-Ingredient Protein versus Collagen Supplementation on Satellite Cell Properties in Males and Females…
- In 24 older adults, a single dose of 3 g calcium beta-hydroxy-beta-methylbutyrate added to 40 g whey boosted muscle protein synthesis in older women and reduced muscle protein breakdown, but the effect was not seen in men.The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A R…
- In people having hip replacement surgery, a pain-relief cocktail that included magnesium sulfate and sodium bicarbonate reduced pain and morphine use and improved early walking, while the abstract does not report muscle strength results.Effects of a Modified Long-Acting Cocktail on Analgesia and Enhanced Recovery After Total Hip Arthroplasty: A Double-Bli…
- In 66 adolescent girls, about 1300 mg daily calcium from milk for 12 weeks did not change body composition or muscle performance, though resistance training did improve them and milk with training improved bone density.Resistance Training and Milk-Substitution Enhance Body Composition and Bone Health in Adolescent Girls.
- In 26 untrained young adults doing 7 weeks of leg strength training, those taking magnesium gained more thigh strength than those on placebo (211 vs 174 Nm).Effect of magnesium supplementation on strength training in humans.
- In a large UK study of adults around age 64, people eating more magnesium had stronger handgrip in both sexes.Associations between diet and handgrip strength: a cross-sectional study from UK Biobank.
- In 2,570 women, higher dietary magnesium was linked with more muscle mass and greater leg explosive power, but not with grip strength.Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the A…
- In a cross-sectional study of 2532 older adults, higher oral magnesium intake was associated with lower odds of sarcopenia in a dose-dependent pattern, even after full adjustment.Association between oral intake magnesium and sarcopenia: a cross-sectional study.
- In 766 black and white adolescents, lower dietary magnesium intake was associated with higher CRP and lower fat-free mass, and almost none of the teens met the recommended magnesium intake.Magnesium Intake, C-Reactive Protein, and Muscle Mass in Adolescents.
- In 53 Chinese men and women aged 18 to 35, calcium intake was similar across age and sex groups, and the study found only correlations between bone, body composition, and muscle strength, with no intervention tested.Muscle-Bone Interactions in Chinese Men and Women Aged 18-35 Years.
- In a retrospective study of 52 middle-aged Chinese women, 12 weeks of a combined supplement with 75 mg magnesium plus vitamin D3, K2, B6 and B12 lowered high-sensitivity CRP, body weight and body fat, with no adverse events reported; muscle gain was not measured and magnesium's own effect could not be separated out.Effects of 12-Week Multiple Micronutrient Supplementation on Immune Function, Body Weight, and Metabolic Parameters in M…
- In elite male basketball, handball and volleyball players, higher magnesium intake from diet was linked with better trunk, grip, jumping and leg strength test scores.Magnesium intake is associated with strength performance in elite basketball, handball and volleyball players.
Review Totals and Summary
Members Only98 reviews · 94% positive
Customers mostly praise the product's cleanliness and versatility. Many buyers say they choose it because it has no sugar, maltodextrin, fructose, fillers or junk. Some say they won't use any other protein powder. Reviewers like that the neutral, unflavored powder mixes easily. They stir it into shakes, meal replacements, yogurt, kefir and lactose-free milk, and they flavor it themselves with pure vanilla or organic stevia. One reviewer called it the best-tasting powder they had found for a meal-replacement shake. Others value that it fits into their own recipes without taking over the taste. Several reviewers link the product to results. They say it helps them keep toned, strong muscle and recover from workouts. Dieters report that it keeps them full for a long time, which helps while they cut weight and try to keep muscle. Buyers also like the zero fat, zero cholesterol and low sodium. They tend to trust the brand's reputation for additive-free manufacturing and Andrew Lessman's other products, and they often describe themselves as long-time repeat customers. The complaints are fewer and mostly about value. The most visible one is price. One loyal customer called it the best whey protein around but said the price had gone up a lot. Another wished each serving had even more protein. Because the product is unflavored, people who want a sweet, dessert-like shake need to add their own flavoring. This product is aimed at purists, so that is a trade-off. I found no consistent complaints about clumping, stomach upset or quality control in the reviews I read. The sample is small. The manufacturer's site shows about 22 reviews, and the HSN and Amazon pages add some more. The reviews are also mostly positive, and retailer-hosted reviews may skew that way. I only read reviews on ProCaps, HSN and Amazon, so the themes above reflect those pages rather than a wide survey of independent forums.
Biohacker Summary
Members Only10 of 10 recommend it
Magnesium is the main ingredient here, and the panel is broadly positive: all ten spoke about it, and about half take it themselves while most of the rest recommend it. The most common reason is sleep, with several taking 400 mg of magnesium threonate before bed and others preferring magnesium glycinate, though one panelist says the evidence that it reliably improves sleep is not yet consistent. Others take it for blood pressure, muscle function and recovery, bone health, brain function, and to make up for low levels that a standard blood test can miss, and some get it through electrolyte drinks. Doses range from 300 mg before bed to 400 to 500 mg a day for most people, and one panelist aims for about a gram, and some pair it with vitamin D3, K2 or calcium. The one caution is that labels can fool you, since some products list the weight of the whole compound instead of the actual elemental magnesium, which can be much lower, and no one said they stopped taking it.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
- Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
- Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
- Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends Magnesium glycinate, stating that 200-400mg elemental helps with sleep as glycine cools the body and magnesium calms.
- Notes that magnesium sits on the NMDA receptor and regulates excitatory transmission, in the context of feeling stressed.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists dairy and sardines as sources of Calcium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Recommends phosphorus as a mineral that, along with calcium, magnesium, and boron, is deposited to fortify the bone structure.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
The ineffective grade rests on trace amounts of calcium and magnesium rather than on whey protein, the main ingredient of this product, for which no direct studies were given. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 14 of the 33 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Muscular system, Digestive system
Combine with: For muscle building, pair whey isolate with creatine monohydrate (3-5 g daily) for strength and lean mass, plus vitamin D3 with K2 and magnesium for muscle and bone support. Omega-3 fish oil can help recovery and reduce inflammation, and a carbohydrate source after training helps replenish glycogen. If the real aim is cellular and DNA repair, add targeted compounds instead: NMN or NR for NAD+ support, resveratrol or pterostilbene, CoQ10 or PQQ for mitochondrial function, and glycine with NAC for glutathione production. Whey can still serve as a protein base alongside these, since adequate protein intake helps preserve muscle with age.
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 0 g · Calcium 40 mg · Phosphorus 20 mg
| Calories | 45 | |
| Total Fat | 0 g | |
| Cholesterol | 0 mg | |
| Sodium | 20 mg | |
| Total Carbohydrates | 0 g | |
| Protein | 10 g | |
| Calcium | 40 mg | |
| Phosphorus | 20 mg | |
| Magnesium | 6 mg |
Other ingredients: Non-GMO Whey Protein Isolate, Sunflower Oil.
Directions: Suggested use mix one or more scoops of Ultimate Whey Protein Isolate with any beverage. Ultimate Whey Protein Isolate mixes easily and is also neutral-tasting. It is fat-free, cholesterol-free and sugar-free and works perfectly with any wellness or weight-loss plan. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle, along with a daily multi-vitamin-mineral formula. For questions about the use of this product call 800.332.7799.
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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