Pruvit KETO//OS NAT Blueberry Acai Charged Review
This eBay listing offers a Pruvit product titled Pruvit BLUEBERRY ACAI Keto OS NAT Ketones Charged 40 Packets NEW Discontinued. The item is sold as new, unused, unopened and undamaged in its original packaging, as stated in the condition field. The item specifics identify the brand as Pruvit, the flavor as Blueberry Acai, and the formulation as powder. The type is listed as Weight Management, and the main purpose is also listed as Weight Management. The type of diet is listed as Keto. The listing states that the package contains 40 pills, and the supply field reads 20. The expiration date is listed as 11/2024. The listing states that a Nutrition Facts label is present. The custom bundle field is set to No. The ingredients field lists Magnesium, Vitamin B12, Vitamin B6, Vitamin C (Ascorbic Acid), Vitamin D, Keto, and Folate. The active ingredients field lists Calcium, Potassium, Sodium, Stevia Rebaudiana (Stevia), Vitamin B12, Vitamin B6, and keto. The country of origin is listed as the United States. The seller is listed as tasteofawesome12, with 100% positive feedback and a stated 2.7K items sold, located in Redlands, California, United States. The listing shows a price of US $180.00 and a sold date of Wed, Aug 26 at 9:43 AM. The eBay item number is 237023869721. The listing states that the seller assumes all responsibility for the listing. Shipping is noted as not available to Paraguay, with delivery listed as varying. The seller does not accept returns. Payment methods shown include Diners Club. The listing also carries eBay Money Back Guarantee language, stating that the buyer will receive the item ordered or a refund. The item description from the seller section on the page is empty, so no additional marketing copy or usage directions are provided in the scraped text. The page also shows an error message stating that the browser is having trouble connecting to the server, with a prompt to refresh. The page does not show any product ratings or written product reviews. The feedback sections shown belong to the seller and to unrelated items sold by the seller, and are therefore not reviews of this supplement.
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Study, Trial or Testing Result Summary
Members Only62 human studies · 20 improved
5 of these 62 human studies gave the ingredient by injection, not by mouth.
Magnesium is the only ingredient here at a full studied dose with some support for energy. In 30 adults with metabolic conditions, 80 milligrams daily for 4 weeks reduced fatigue [1]. In 64 women with polycystic ovary syndrome, 10 weeks of magnesium improved energy and fatigue scores [2]. Magnesium with B vitamins reduced fatigue in 98 adults with inflammatory bowel disease [3]. Weekly magnesium injections helped 12 of 15 people with chronic fatigue syndrome [4]. Other trials in fibromyalgia found no fatigue benefit [5][6]. Vitamin B6 is below the 50 milligram dose that eased tiredness in one small trial [7], and larger trials of blends with vitamin B6 found no benefit [8][9]. Vitamin B12 did not improve energy in people who were not deficient [10][11]. Calcium is well below the dose that reduced tiredness in women with premenstrual syndrome [12], and trials in runners found no benefit [13]. The largest ingredient, the 12.6 gram N8 Max Nat Blend, has no human studies given here. Animal and cell studies are never counted.
See all 62 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- A review of 26 trials in 3,273 people with chronic fatigue syndrome found most supplements did not help, but magnesium and NADH showed benefit, though the trials were small and at high risk of bias.Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of four diet trials in people with multiple sclerosis found that two diets providing enough folate and magnesium reduced fatigue, but firm conclusions were not possible.Is there an effect of dietary intake on MS-related fatigue? - A systematic literature review.
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 202 dialysis patients given a multinutrient supplement including B6 for 12 weeks, fatigue and quality of life did not differ from placebo, though some heart rate variability measures and a herpes virus level improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 110 people with fibromyalgia, 3 months of a supplement with coenzyme Q10, tryptophan and magnesium did not significantly reduce fatigue (placebo improved significantly), though pain, sleep and overall impact improved.Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomiz…
- In 98 adults with inflammatory bowel disease in remission, 4 weeks of magnesium plus B vitamins reduced fatigue more than placebo, and also lowered ulcerative colitis symptom scores but not Crohn's disease scores.Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 64 women with polycystic ovary syndrome, 10 weeks of magnesium improved the energy and fatigue score and total quality of life compared with placebo.The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 49 patients after colon surgery, magnesium oxide (1 g every 12 hours) did not change fatigue or bowel recovery compared with placebo.Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 32 people with chronic fatigue syndrome, weekly magnesium sulphate injections for 6 weeks led 12 of 15 treated patients to report benefit and better energy, versus 3 of 17 on placebo.Red blood cell magnesium and chronic fatigue syndrome.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 30 adults with hypertension, diabetes or high blood fats, drinking water with 80 mg of magnesium daily for 4 weeks improved body mass index, insulin, triglycerides and fatigue compared with placebo water.Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes.
- In 25 healthy recreationally active adults, a single dose of a pre-workout supplement containing vitamin B12 as methylcobalamin, along with caffeine, raised self-reported vigor and energy compared with a placebo drink, though exercise performance did not change.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 resistance-trained people, a week of a pre-workout drink containing 45 mcg B12 and other ingredients helped maintain some strength and lifting measures versus placebo but did not change cycling time trial performance.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 22 college-aged adults taking 350 mg of magnesium daily for 10 days, muscle soreness and perceived recovery improved compared with placebo, but performance gains did not reach statistical significance.Effects of Magnesium Supplementation on Muscle Soreness and Performance.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 20 junior cyclists, a daily multi-nutrient tablet containing magnesium for 4 weeks led to faster fatigue recovery than a plain vitamin product, but magnesium was not tested alone.Studies concerning the ergogenic value of Cantamega-2000 supply in top junior cyclists.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 16 trained men with two nights of short sleep, zinc magnesium aspartate had no effect on sleep, ratings of fatigue or morning weightlifting performance compared with placebo.Effects of Supplementing Zinc Magnesium Aspartate on Sleep Quality and Submaximal Weightlifting Performance, following T…
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In people with fibromyalgia, 100 mg of magnesium daily for one month did not change fatigue more than placebo.Short-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinica…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 92 patients with high blood pressure, magnesium at 320 mg a day reduced some complaints such as nervousness and sleep problems but had no effect on mental or physical fatigue.[Level of total and ionized magnesium fraction based on biochemical analysis of blood and hair and effect of supplemente…
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- Eight healthy young men taking 6 grams of potassium-magnesium aspartate over 24 hours before a hard cycling test lasted about as long to exhaustion as those given placebo, so no endurance benefit was seen.The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise …
- In breast cancer patients taking 400 mg of magnesium oxide daily for 4 weeks, fatigue was significantly reduced, though this single-group pilot study had no placebo comparison.A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients.
- In a large cohort of about 81,500 women aged 60 and older followed for a median of 16 years, higher magnesium intake was linked to a lower risk of frailty, with the top fifth of intake showing 12% lower risk than the bottom fifth.Total magnesium intake and risk of frailty in older women.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In a 3.5-year study of 1,643 adults aged 65 and older, those with the lowest dietary vitamin B6 intake had about 2.8 times the odds of developing frailty, which includes exhaustion, compared with those with the highest intake. This is an association from diet, not proof that supplements prevent frailty.Low vitamin intake is associated with risk of frailty in older adults.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- Red blood cell magnesium was normal in 89 people with chronic fatigue syndrome, and a magnesium loading test in 6 of them found no deficiency, so the authors saw no reason to use magnesium treatment for this condition.Normal red cell magnesium concentrations and magnesium loading tests in patients with chronic fatigue syndrome.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
Review Totals and Summary
Members Only98 reviews · 93% positive
Buyers who wrote in are very positive. They mostly describe clearer thinking, steadier energy and better focus, though the reviews say little about the downsides. **What buyers say it did for them:** The main theme is mental clarity and focus. One buyer says "I could think clearly again," and another says "My focus is sharp again." Several describe being rid of brain fog, with one writing "Light bulbs are flipped back on." Energy is the second theme. One buyer says it gives "sustained energy the entire day," and another simply says "More sustained energy." One reviewer also credits it with improved mood and sleep, saying "I gained myself back," and describes having been moody, exhausted and unable to sleep before. **What they complain about:** The reviews contain no complaints. Nobody mentions side effects, a failure to work, or any problem with the product. That doesn't prove there are none, only that these reviews don't raise any. **Taste, smell, pill size or form:** The reviews don't discuss flavor, smell, mixing or texture, so they give no guide on whether you'll like the Blueberry Acai taste. Nothing here comes from other forms of the product, and any reviews about gummies or capsules were left out of this summary. **Value for money:** Price and value are not mentioned in any review, so there is nothing here to judge whether it is worth the cost. **Who it seems to suit and who it did not:** The reviewers are busy people who need to stay mentally sharp. One is a corporate employee who also runs a business, one is a mom, and one says "My brain is my income." One reviewer mentions being 52 and feeling that her brain didn't "click" the way it should. Those who felt run down, foggy or unfocused report the most benefit. No reviewer says the product didn't suit them, so the reviews give no information on who should avoid it. **Bottom line:** If you want help with focus, mental clarity and all-day energy, these reviews are encouraging. They are short, personal accounts, and they say nothing about taste, price or drawbacks. Look elsewhere for that information before buying.
Biohacker Summary
Members Only9 of 10 recommend it
Magnesium is the main ingredient here, and nearly the whole panel speaks well of it: all ten mention it, with four saying they use it and most of the rest recommending it, though a few stay neutral and point out that sleep evidence is mixed. Sleep is the top reason, with bedtime doses of 400 mg of magnesium threonate described by three of them and glycinate favored by two, while others cite blood pressure, muscle function, mood, brain health, bone health and electrolytes during fasting or exercise. Doses named include 300 mg before bed, 400 to 500 mg a day as a general need, and one person aiming for about a gram, and several pair it with sodium and potassium in electrolyte drinks or with vitamins D3 and K2. One panelist warns that labels can mislead by listing the whole compound weight instead of the actual magnesium, and nobody said they stopped taking it. Calcium and vitamin B12 are smaller ingredients in this product, and each got only brief mentions from the panel.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
- Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
- Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
- Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
- Notes additional gaps in calcium.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends Magnesium glycinate, stating that 200-400mg elemental helps with sleep as glycine cools the body and magnesium calms.
- Notes that magnesium sits on the NMDA receptor and regulates excitatory transmission, in the context of feeling stressed.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists dairy and sardines as sources of Calcium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
RAL Summary
Members OnlyTier 3 for Energy
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Muscular system, Metabolic system
Combine with: For its actual purpose of energy, ketosis support, and focus, this product pairs well with electrolytes (sodium, potassium, magnesium) to ease keto-flu symptoms, MCT oil or C8 MCT powder for additional ketone production, and L-theanine to smooth out the caffeine and reduce jitters. B-complex vitamins, CoQ10, and omega-3s can support energy metabolism. If you need heartburn relief, use a separate product designed for it, such as calcium carbonate or magnesium hydroxide antacids, an alginate (sodium alginate) raft-forming formula, or DGL licorice, and take it apart from this caffeinated drink. Avoid taking it on an empty stomach if you are prone to reflux.
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 5 g · Vitamin B6 5 mg · Vitamin B12 100 mcg
| Calories | 50 | |
| Total Carbohydrates | 5 g | |
| Vitamin B6 | 5 mg | |
| Vitamin B12 | 100 mcg | |
| Calcium | 230 mg | |
| Magnesium | 235 mg | |
| Sodium | 910 mg | |
| N8 Max Nat Blend | 12.6 g | † |
Other ingredients: Erythritol, Natural Flavors, Citric Acid, Malic Acid, Rebaudioside A, Caffeine, Xanthan Gum, Fruit juice.
Directions: Directions: Dissolve 1 packet in 12-16 oz of cold water & shake/stir vigorously and with purpose. Can be taken with or without food. Novel use = 1 daily serving Optimal performance = 2 daily servings AM/PM Must be consumed with SIGNAL//OS for DNA repair and other therapeutic benefits associated with C-Med 100.
Label source: NIH label database · Report a label change
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Our articles on this subject
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
- Melatonin vs Magnesium for Sleep: What the Studies ShowArticle · Nov 3, 2026
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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