Steel ANTI-Eˣ Review
**Limited verification.** My live search found little detail on this product, so this description is shorter than the 300–500 words you asked for. I didn't want to pad it with invented ingredient doses or mechanisms. Steel ANTI-Eˣ is a new release from Steel Supplements, a US sports-nutrition brand that markets itself as research-focused. It sells for about $80 on the brand's own site. The listing describes it as "Estrogen control". It is also sold in an "Alpha & ANTI-Eˣ Stack" for $148, discounted from $160. That stack is described as advanced testosterone and PCT (post-cycle therapy) support. So it is positioned as a companion to the brand's testosterone-support product, "Alpha". The snippets I could read did not show the label, ingredient list, doses or serving directions. I therefore can't say which compounds it contains. Products in the "estrogen control" category usually try to limit the conversion of testosterone to estradiol (aromatase) or support estrogen metabolism in the liver. Common ingredients for this include DIM, calcium-D-glucarate and chrysin. I did not confirm that any of these are in ANTI-Eˣ, so treat that as general category background, not a description of this formula. I also found no independent professional analysis, such as a lab test or a review by a dietitian or physician. Supplements that claim to alter hormone balance are not FDA-approved to treat any condition. Anyone with a hormone-related condition, or anyone using testosterone or other hormonal drugs, should talk to a clinician before using one. Check the product's Supplement Facts panel on steelsupplements.com for the exact formula.
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Study, Trial or Testing Result Summary
Members Only2 human studies · 0 improved
No human study has tested 3-deoxy-7-oxo-DHEA, the only ingredient in this product, for male hormones. The two studies found used close relatives, 7-oxo forms of the hormone building block DHEA. In a placebo-controlled trial, 22 healthy men took 3-acetyl-7-oxo-DHEA at up to 200 milligrams a day. Testosterone, estrogen, the stress hormone cortisol and other hormones stayed in the normal range and did not change, and the treatment was well tolerated [1]. In a small study without a placebo group, 10 men aged 27 to 72 applied a 7-oxo-DHEA skin gel for 5 days. Testosterone and estrogen fell, and luteinizing hormone, the brain signal that tells the testes to make testosterone, rose. Good cholesterol rose and the overall cholesterol profile improved, though two other blood fats rose slightly [2]. This product gives 37.5 milligrams a day of a different, related compound. That is well below the top dose in the trial, and it is not the form that was studied. Both studies were small and short, and neither showed a benefit for male hormones. Animal and cell studies are never counted.
See all 2 studies →Hide the studies
- In 22 healthy men given 3-acetyl-7-oxo-DHEA at up to 200 mg a day (the top dose for 4 weeks) or placebo, blood levels of testosterone, estradiol, cortisol and other hormones stayed in the normal range and did not change, and the treatment was well tolerated.Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male voluntee…
- In 10 men aged 27 to 72, a 7-oxo-DHEA skin gel applied for 5 days lowered testosterone and estradiol, raised the luteinizing hormone and HDL cholesterol, and slightly raised apolipoprotein B and lipoprotein(a), with an overall improvement in the cholesterol profile.Read the study on PubMed (11300231) →
Review Totals and Summary
Members Only819 reviews · 95% positive
**No product-specific reviews found.** The brand's own listing for ANTI-Eˣ showed "No reviews" when I searched. It is a recent release, and I found no third-party reviews of it either. I can't honestly report customer feedback on this specific product, and I haven't made any up. The only related feedback I could read was about Steel Supplements as a company. It comes from Trustpilot and covers other products, so it may not apply to ANTI-Eˣ. - **Positive:** One reviewer on a fat-loss stack reported visible changes in their appearance and stubborn fat loss after a month. The same reviewer mentioned headaches and irritability as side effects. - **Negative on refunds:** One buyer of a different product, an ED supplement, saw no results after 30 days. They said getting a refund under the advertised 60-day money-back guarantee was difficult. - **Negative on shipping:** Another reviewer complained of very slow delivery, with tracking that did not update for weeks. - **Negative on accessories:** A buyer said a protein shaker bottle did not mix well, and that support was unhelpful. The brand's site shows a very high overall star rating. That rating covers the whole store and tells you nothing about this product. If you want a real summary of ANTI-Eˣ feedback, check again after more buyers have posted reviews. Good places to look are Trustpilot, Reddit communities such as r/Supplements, and the product page on steelsupplements.com.
Biohacker Summary
Members Only6 of 10 recommend it
Most of the panel recommends or uses DHEA, the main ingredient, and the usual reason is to make up for low levels, which several of them say drop with age and stress. Four of them lean toward women in their mid-30s and older, and several suggest checking blood levels first, using the DHEA sulfate marker. Forms and doses vary: oral drops, a basic oral capsule at 25 to 50 mg with advice to start lower, 25 mg once a day, a dose taken before bed, and vaginal or cream versions for tissue health, comfort and libido. One panelist stopped after his estrogen and fat rose under stress, another warns against using it without a clinician watching lab results, and a few stay neutral and point to mixed views on fertility and possible downsides.
See all 10 biohackers →Hide the biohackers
Dave Asprey · DHEA · neutral
- The conversation covers DHEA and thyroid optimization for women over 35.
- Recommends women start taking DHEA around age 35 to counterbalance stress hormones, calling it a major longevity thing.
- Notes that around age 35, the body makes less DHEA, which counters stress hormones and provides stress resilience.
- Mentions that DHEA is also a great solution for genital urinary syndrome of menopause.
- Dave Asprey's DHEA levels were at zero, and while he used to feel bad taking it, with all the stuff he's done around longevity, he now takes 20 oil suspended oral drops and it works fine.
- Recommends that women around 35 measure and start supplementing DHEA to have counter-stress hormones and build resilience.
- Suggests that perimenopausal women might want to take DHEA to help manage stress, as their natural levels of anti-stress hormones have tanked.
- States that if you fix the cellular factory and start young enough, you will make enough DHEA in your body and won't need to supplement it.
- Added DHEA to his regimen this year on the recommendation of his biohacker mom, noting it has been keeping him relatively young.
- Recommends including DHEA in an advanced sex hormone panel.
Andrew Huberman · DHEA · neutral
- Mentions that some fertility experts recommend DHEA for fertility, while others do not.
- Mentions a study where a cocktail of growth hormone, a med, and DHEA was given for 12 months, resulting in increased thymic size and improved immune cell markers.
- Recommends Intrarosa, a vaginal DHEA preparation, especially for breast cancer patients, as it converts to testosterone and estradiol in the vulva.
- Discusses hormones, cortisol, DHEA, testosterone, and GABA in relation to OCD.
- Discusses a study showing elevated DHEA in females with OCD, noting that DHEA is a potent antagonist of the GABA system, which could lead to reduced GABA transmission and increased excitation in brain networks.
- Discusses DHEA and its effects on hormone levels and ratios.
- Warns that DHEA will increase both testosterone and estrogen, and the extent to which it increases one or the other depends on starting hormone levels and aromatase activity, potentially shuttling DHEA towards estrogen production.
- I'd want to know about DHEA and sort of the whole androgen pathway. I'd want to know about the metabolites of estrogen, because some of them are protective and very helpful. Others are a bit like Homer Simpson. I mean, they are just causing all kinds of problems in your body.
Dr. Mark Hyman · DHEA · recommends
- Finds looking at precursors to hormones like DHEA most helpful in practice, as low levels can be a simple path to supporting all hormones.
- Recommends vaginal DHEA for improving libido, in addition to improving the health of vaginal tissues.
- Notes that DHEA pools plummet when someone is overtraining and experiencing high stress response, and that fixing the underlying fatigue will cause DHEA levels to go back up.
- Suggests supplementing with DHEA if someone has low double-digit levels, which is often caused by stress, to restart hormone production.
- Mentions DHEA as a hormone that, when high, contributes to androgen dominance and can lead to hair thinning and hair loss.
- Mentions that DHEA, which gets converted down the pathway to both estrogen and testosterone, is helpful for sexual dysfunction.
- Identifies DHEA as an androgenic hormone precursor to testosterone and estrogen, typically elevated in PCOS and potentially indicating a stress response.
- Notes that DHEA, a precursor of estrogen and testosterone, has been shown to help improve tissue integrity, reduce urinary tract infections, and help with libido, specifically mentioning intravaginal DHEA as a new approach for vaginal dryness.
- States that sometimes DHEA, a hormone, can help with low testosterone.
- States that DHEA sulfate levels go down as we age and are under stress, leading to faster aging, more fatigue, and less libido, and that checking DHEA levels is important to understand one's stress response and what can be done about it.
Siim Land · DHEA · uses
- Has DHEA sulfate on his radar as one of the biomarkers to measure to track androgenic status, especially for health optimizers.
- States that DHEA has very little relevance for men, with practical outcomes being much less significant than for women, where it can be more impactful and potentially improve body composition.
- Discusses DHEA as a supplement.
- Recommends tracking DHEA sulfate, as androgens decline significantly during aging, and ignoring it can lead to not knowing about the age-related decline until it's too late.
- Tracks DHEA sulfate as a precursor to testosterone and a more abundant a med, noting his levels have declined from youthful to aged, and he is actively trying to reverse this trend without TRT.
- Discusses DHEA, stating that it's a precursor to testosterone and estrogen, and that Bryan Johnson uses it to maintain his hormone levels.
- Discusses the benefits of DHEA supplementation.
Peter Attia · DHEA · uses
- Uses DHEA intravaginally for pain of the vagina.
- Notes that DHEA sulfate is the only proxy in traditional blood work metrics to test for DHEA levels.
- Derek explores the benefits and risks of DHEA supplementation for women, and the differing effects on men versus women.
- Takes 25 mg of DHEA once a day for hormone replacement.
- Mentions there is more limited evidence for topical DHEA (prasterone), which converts locally into estrogen and testosterone and is approved for GSM.
Dr. Rhonda Patrick · DHEA · recommends
- Suggests that women with low DHEA, assessed via DHEAS biomarker, may benefit from a basic DHEA oral supplement to help with testosterone conversion, noting that 25 to 50 mg is seen in studies but advises starting lower.
Ben Greenfield · DHEA · recommends
- Suggests considering DHEA as an upstream preventative hormonal optimization, especially for women in their mid-30s and beyond with high stress.
- Went on DHEA for a period because his levels were low, but due to stress and cortisol, it flipped to estrogen, causing his estrogen to go through the roof and increase his fat.
- The show notes mention exploring Dave's use of supplements like DHEA to support his testosterone levels and overall well-being.
- Began supplementing with DHEA because his markers were low, and he saw a good increase in his testosterone from doing so.
- Recommends applying a compounded DHEA cream vaginally to help with lubrication, increase circulation for engorgement, and improve sexual satisfaction.
- Mentions DHEA as a precursor to testosterone replacement therapy, noting that if foundational practices are followed, it will work even better.
- Loves DHEA and prefers oral DHEA in small amounts, especially for women with low adrenal status, as it is anabolic, protects muscles, helps with insulin resistance and blood sugar control, and is a prohormone for testosterone and estrogens.
- Ben's wife takes very small amounts of DHEA, which he thinks is fantastic, especially for perimenopausal and post-menopausal women.
- States that he doesn't have an issue with DHEA, and his wife takes small amounts, finding it fantastic, especially for perimenopausal and postmenopausal women at 10 to 20 mg.
- Takes DHEA daily, recommending 25 to 50 milligrams for males over 35, as it helps synthesize testosterone and improves his energy and mood.
Dr. Eric Berg · DHEA · neutral
- Notes that DHEA was given in a study to prevent the side effect of diabetes from growth hormone.
- Notes that DHEA works to suppress luteinizing hormone and increase progesterone, and also suppresses cortisol.
- Mentions DHEA as a supplement that can help decrease luteinizing hormone and cortisol levels, suggesting a blood test to check levels before taking it.
- Mentions that DHEA can be taken as a supplement to help with hormones if needed, but does not focus on it in this video.
- Recommends DHEA supplements to boost testosterone levels.
- Suggests DHEA might be a good supplement to help substantiate or fortify adrenals, providing extra material for making testosterone.
- Recommends trying DHEA, with 25 mg for women and 100 mg for men, as it is a precursor for hormones that help build muscle.
- Recommends taking DHEA, suggesting 25 milligrams for females and 100 milligrams for males, as it helps build muscle and acts as a precursor.
- Recommends taking DHEA to help lose belly fat after menopause.
- States that the breathing technique can help increase DHEA, which is a precursor for all adrenal hormones.
Bryan Johnson · DHEA · uses
- Takes DHEA before bed.
Thomas DeLauer · DHEA · warns
- Advises against messing with DHEA due to its far upstream position in the hormone cascade, recommending it only under the guidance of a clinician who monitors lab values, as the body's downstream reaction is unpredictable.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Men
The 819 reviews at 95% positive do not appear to be for ANTI-Eˣ, because the product page showed no reviews and the only readable feedback was store-wide Trustpilot feedback about other Steel Supplements products. Its reviews are set aside, so it is graded on its studies alone. Promising, but human evidence is thin and there are 0 reviews.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 1 of the 2 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system, Cardiovascular system
Combine with: For male hormone balance, ANTI-Eˣ could be paired with zinc and magnesium, which support healthy testosterone levels, along with vitamin D3 and K2. Cruciferous-derived compounds like DIM or calcium D-glucarate can complement estrogen metabolism, and boron may support free testosterone. If the real goal is adrenal support, add adaptogens such as ashwagandha, rhodiola, or holy basil, plus vitamin C, B5 (pantothenic acid), and B6 to support the stress response. Consult a healthcare provider before combining hormone-modulating products, especially with existing medications or conditions.
Possible side effects: In the studies the related compound was well tolerated by mouth, while a skin gel form lowered testosterone and estrogen and slightly raised two blood fats. No product-specific reviews were read.
Supplement Facts
3-deoxy-7-oxo-DHEA 37.5 mg
| 3-deoxy-7-oxo-DHEA | 37.5 mg | † |
Other ingredients: Gelatin (Capsule), Dicalcium Phosphate, Magnesium Stearate, Silicon Dioxide.
Label source: Reverseagelab · Report a label change
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Graded November 11, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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