Sundown Naturals CO Q-10 200 mg Review
Sundown Naturals Co Q-10 200 mg is listed on this page as a 40 count softgel supplement in a bottle, with packaging that may vary. The product is unflavored and is classed as a vitamin, with Coenzyme Q listed as its special ingredient. The item form is softgel and the diet type is gluten free. The product benefits are listed as replenishing. The item count is 40 count and the item weight is 0.1 pounds, with dimensions of 47 x 47 x 93 millimeters. The brand is Sundown and the item trademark is SUNDOWN NATURALS. The listed category is nutritional supplement. The page lists the product as currently unavailable, and it notes that the item is discontinued by the manufacturer. The page does not show a price or an ingredients list. The product description on the page consists only of the line Brand: Sundown Naturals, so the specifications above are the main product information available. The model number and manufacturer part number are both listed as 65348, and the ASIN is B000PT2374.
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Study, Trial or Testing Result Summary
Members Only26 human studies · 19 improved
This product gives 200 mg of coenzyme Q10 a day, a full dose, above the 100 mg that worked in studies. Across 26 human studies, 19 showed an improvement and 4 showed no effect. A 2024 review of 12 trials with 489 people found coenzyme Q10 improved how well blood vessels widen when blood flow rises, with bigger gains at higher doses [1]. An earlier review of five placebo-controlled trials with 194 people found the same [2]. In people with heart failure and weak heart pumping, more than 100 mg daily for at least 6 months cut deaths from any cause by 36% and from heart causes by 55% across four trials with 1139 people [3]. In 60 adults with fatty liver, 240 mg daily for 6 months improved vessel widening, artery stiffness and heart blood flow reserve [4]. In 56 people with weak heart pumping from coronary disease, 300 mg daily for 8 weeks improved vessel widening more than placebo [5]. In 51 adults with high cholesterol, 100 or 200 mg of the reduced form for 8 weeks improved vessel widening [6]. Some smaller trials found no change in blood flow or artery stiffness. No study reported what share of people improved. Animal and cell studies are never counted.
See all 26 studies →Hide the studies
- In four placebo-controlled trials of 1139 people with heart failure and weak heart pumping, taking more than 100 mg of coenzyme Q10 daily for at least 6 months cut the risk of death from any cause by 36% and from heart causes by 55%.[Coenzyme Q-10 in the treatment of patients with chronic heart failure and reduced left ventricular ejection fraction: s…
- Across 12 trials with 489 people, coenzyme Q10 raised blood vessel widening after blood flow increase (a measure of vessel health), more so at higher doses, but did not change blood vessel adhesion markers.Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Random…
- In five placebo-controlled trials of 194 people, coenzyme Q10 significantly improved blood vessel widening after blood flow increase, but not widening in response to nitrate.Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials.
- In a review of 20 articles with 483 people with rheumatic diseases, coenzyme Q10 improved blood vessel function in antiphospholipid syndrome and eased symptoms in arthritis and fibromyalgia, with few side effects.Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
- A review of 19 trials in heart failure found that ubiquinol (a form of coenzyme Q10) among other supplements raised the heart's pumping fraction, but no definitive evidence on outcomes exists.Dietary strategies and nutritional supplements in the management of heart failure: a systematic review.
- In 213 older adults low in selenium, 200 mg a day of coenzyme Q10 plus selenium for 4 years prevented a rise in D-dimer (a clotting marker) and lowered heart-related deaths compared with placebo in those with high D-dimer.Dietary Supplementation with Selenium and Coenzyme Q10 Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular…
- In 80 people with type 2 diabetes and abnormal blood fats, 200 mg of coenzyme Q10 daily for 12 weeks did not significantly change forearm blood flow on its own; only combined with fenofibrate did blood flow improve.Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes.
- In 65 firefighters, four tablets daily of aged garlic extract plus coenzyme Q10 (120 mg total) for one year reduced artery stiffness and improved blood vessel function compared with placebo.Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH ra…
- In 64 people with type 2 diabetes, 200 mg of coenzyme Q10 daily for 12 weeks improved a blood vessel risk marker (ADMA) and nitric oxide products compared with placebo.Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes …
- In 60 adults with fatty liver disease, 240 mg of coenzyme Q10 daily for 6 months improved blood vessel dilation, artery stiffness, small vessel health and coronary blood flow reserve, while placebo showed no improvement.Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial fun…
- In 56 patients with weakened heart pumping from coronary disease, 300 mg of coenzyme Q10 daily for 8 weeks improved blood vessel dilation by 1.51% more than placebo and improved a marker of mitochondrial function.Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemi…
- In 51 overweight adults (36 completed), 200 mg of coenzyme Q10 daily for 12 weeks did not change artery stiffness, blood fats or inflammation markers compared with placebo.Effects of coenzyme Q10 on arterial stiffness, metabolic parameters, and fatigue in obese subjects: a double-blind rando…
- In 51 adults with moderately high cholesterol and impaired blood vessel dilation, 100 or 200 mg a day of ubiquinol for 8 weeks improved blood vessel dilation by about 1.3% more than placebo and raised nitric oxide products.Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Tria…
- In a randomized trial of 50 adults with dyslipidemia, a 6-week combination containing 2 mg of coenzyme Q10 improved lipids, but only a different combination improved endothelial function.Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot…
- In a placebo-controlled trial of 40 moderately high-cholesterol adults, a six-month product containing 30 mg of coenzyme Q10 with red yeast rice improved endothelial reactivity and arterial stiffness, though the coenzyme Q10 effect was not separated from the red yeast rice.Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity…
- In a placebo-controlled trial of 38 people with coronary artery disease, 300 mg of coenzyme Q10 daily for one month improved blood vessel dilation and peak oxygen uptake more than placebo.Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with is…
- In 36 people with antiphospholipid syndrome, 200 mg per day of ubiquinol for 1 month improved endothelial function and reduced immune cell markers of clotting and inflammation compared with placebo, with no significant side effects.Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.
- In 25 men with impaired artery function, coenzyme Q10 supplementation improved flow-mediated dilation of the brachial artery in a randomized crossover study.Influence of coenzyme Q(10) and cerivastatin on the flow-mediated vasodilation of the brachial artery: results of the EN…
- In 18 people with chronic kidney disease, 20 mg per day of a mitochondria-targeted ubiquinol for 4 weeks improved flow-mediated dilation compared with placebo, while exercise capacity did not change.Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a ra…
- In 14 adults with heart failure and reduced pumping, 400 mg of ubiquinol daily for three months significantly improved peripheral blood vessel function, while placebo did not.Ubiquinol Improves Endothelial Function in Patients with Heart Failure with Reduced Ejection Fraction: A Single-Center, …
- In a crossover trial of 12 adults with high cholesterol, 150 mg of coenzyme Q10 daily for four weeks made LDL cholesterol harder to oxidize but did not improve blood vessel dilation compared with placebo.Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemi…
- In 50 young adults, 2 weeks of coenzyme Q10 narrowed the gap in skin blood flow responses between Asian and Caucasian participants, while placebo made no difference.CoQ10 and endothelial function in Asians from Korea compared to Asians born in the United States and US born Caucasians.
- In 23 adults with chronic heart failure, 100 mg of coenzyme Q10 three times daily for four weeks improved peak exercise oxygen uptake, blood vessel dilation, and heart contraction compared with placebo.Coenzyme Q10 and exercise training in chronic heart failure.
- In 15 middle-aged men, 150 mg of coenzyme Q10 daily for two months raised blood levels and felt energy but did not change maximal oxygen use, lactate threshold, or forearm blood flow compared with placebo.The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men.
- In a retrospective study of 156 patients with viral myocarditis, adding trimetazidine to coenzyme Q10 gave a 90.5% effective rate versus 77.8% with coenzyme Q10 alone, with better oxidative stress and inflammation markers after two weeks.The effect of coenzyme Q10 plus trimetazidine on acute viral myocarditis treatment.
- In a small 4-week pilot in 10 healthy adults, a blend containing coenzyme Q10 improved endothelial function, and half of the participants with existing endothelial dysfunction reached normal levels, though the coenzyme Q10 dose and its separate effect were not reported.Oral nutraceutical intervention to improve endothelial function: Evidence from in vitro and pilot clinical studies.
Review Totals and Summary
Members Only113 reviews · 86% positive
Buyers are very happy with Sundown Naturals CoQ10 200 mg softgels, with about 113 ratings across the stores and every starred review giving 4 or 5. Reviews on this page are mostly short, and the praise centers on quality, price and easy swallowing. **What buyers say it did for them:** Several describe a benefit, mostly around muscles and energy. One person takes it with a med and says "it is helping" with cramps and aching. Another credits it for migraines and muscle pain: "It totally works as well as helping with muscle pain and spasms." One reviewer reports an improvement in heart rhythm, tiredness and energy after starting it. The store summary adds that some reviewers mention a better energy level, a doctor who is satisfied with the results, and faster recovery from colds. **What they complain about:** Complaints are few. One reviewer says there is "No way to tell if the coq10 does what" it should, beyond still being here. The store summary notes that effectiveness claims rest on personal experience rather than measured results. It also mentions one reviewer who warns to check the expiration date and was unhappy with the vendor, though they still found the product fine and effective. Nothing else negative appears. **Taste, smell, pill size and form:** Swallowing is a repeated point of praise. One reviewer calls it "a decent capsule size" with the potency "right," and another says the pills are "easy to swallow." The store summary says reviewers describe the softgels as smooth and easy to take. No one comments on taste or smell. Some reviewers say "caplets" or "capsule," but these are the same product as described on the page. Reviews of other forms such as gummies or powder were left out. **Value for money:** Buyers see it as fairly priced. One says "Excellent Product! Great Price!" and another says "The price doesn't stress me out." A reviewer taking it for a med discomfort says any relief is "worth the $" even with another pill to take. The store summary calls it a good deal. **Who it seems to suit and who it did not:** It seems to suit people who take a med and want relief from muscle aches, and people whose doctor suggested CoQ10, including one whose neurologist recommended it with magnesium for migraines. It also suits repeat buyers who already trust the brand: "I am a lifelong fan." One reviewer has bought it for about a year. Shipping got praise too, with one buyer saying it "came so fast." No reviewer said it was unsuitable for them. The one reviewer who could not tell whether it works may be a sign that benefits are not noticeable for everyone.
Biohacker Summary
Members Only7 of 10 recommend it
Coenzyme Q10 is the main ingredient here, and the panel leans favorable: four of the nine who spoke say they use it or recommend it, while the rest are neutral, and one has stopped. Most take it to support the mitochondria, the cell parts that make energy, and also for heart health, fatigue, brain health, and because meds can lower the body's levels; doses mentioned run from 100 to 400 mg a day, with one at 300 mg and another saying some people go up to 1200 mg. One favors the ubiquinol form and another favors a crystal-free form for better absorption, while Huberman's advice is to take it with a fat-containing meal such as dinner, and it is paired with omega-3 and PQQ. Cautions come from a few members: one says there is no real longevity evidence, another says there is no good data that it prevents muscle symptoms from meds, and one says standard forms rarely reach the mitochondria.
See all 9 biohackers →Hide the biohackers
Dr. Eric Berg · Coenzyme Q10 · neutral
- Mentions that grass-fed liver has coenzyme Q10.
- Recommends that anyone with a med prescription should also take coenzyme Q10, specifically the ubiquinol form, to support heart and muscle function.
- Notes that Merck filed a patent for a med combined with coenzyme Q10, but never added it back into the formula, and that major heart organizations do not recommend taking coenzyme Q10 alongside meds.
- Recommends taking coenzyme Q10, specifically ubiquinol, to prevent the side effects of meds, especially for those experiencing muscle weakness, pain, fatigue, or exercise intolerance. He suggests a dose of 200 to 400 mg, or even up to 1200 mg a day for some individuals.
- Mentions that coenzyme Q10 supports the heart and mitochondria as a powerful antioxidant, and meds deplete its production.
- States that coenzyme Q10 has been known to help people with fibromyalgia feel better.
- Recommends Coenzyme Q10, especially for those on meds, as it's a key nutrient for energy in the mitochondria and works with vitamin E and selenium, and suggests taking it at lunch with a meal.
- Recommends coenzyme Q10 as a remedy for long COVID.
- Mentions that meds block coenzyme Q10 and refers to another video where he discusses it.
- Dr. Berg highlights coenzyme Q10 as a key essential nutrient for mitochondria in the heart, and recommends taking it if on meds, as meds deplete this nutrient.
Dave Asprey · Coenzyme Q10 · uses
- States he takes 300 mg of Coenzyme Q10 every day for 20 years because it is necessary for mitochondria to function and is important for longevity, noting that meds lower it.
- Recommends coenzyme Q10 (CoQ10) to support mitochondria, as it helps generate energy and fights oxidative stress.
- Mentions that there are methylation genes for Coenzyme Q10 that convert it to ubiquinol.
- Suggests taking Coenzyme Q10 to optimize mitochondria.
- Mentions Coenzyme Q10 as something that can change blood viscosity, alongside sunlight and earthing.
- Includes Coenzyme Q10 as a helpful addition to a med protocol.
- Used to give his dog coenzyme Q10 for mitochondrial function.
- Dave Asprey mentions Coenzyme Q10 as something one might take to boost ATP production.
- Dave Asprey mentions that Coenzyme Q10 is a big deal for a lot of people regarding energy.
- Mentions Coenzyme Q10 as one of the micronutrients that can help protect the glycocalyx.
Andrew Huberman · Coenzyme Q10 · uses
- Personally takes Omega-3 and Coenzyme Q10 every day, noting they are known to support cardiovascular health, cellular health and energy, and brain health.
- Personally takes coenzyme Q10 every day, noting it supports cardiovascular health, cellular health, energy, and brain health.
- Discusses a study where probiotics, magnesium orotate, and coenzyme Q10 showed a short-term improvement in symptoms of major depression.
- Discusses Coenzyme Q10 as a fertility supplement.
- Recommends Coenzyme Q10 at 100 to 400 milligrams per day, taken with a meal containing fat, ideally dinner, to improve sperm quality by supporting mitochondrial health, which is vital for sperm formation and fertilization.
- States that coenzyme Q10 should be taken with food.
- Mentions Coenzyme Q10 as a tool for fertility.
- Andrew Huberman says he personally takes AG1's new Omega-3 Coenzyme Q10 product every day, noting that Omega-3 and Coenzyme Q10 are known to support cardiovascular health, cellular health, energy, and brain health.
- Andrew Huberman notes that some papers suggest coenzyme Q10 might be beneficial for egg quality.
Thomas DeLauer · Coenzyme Q10 · uses
- States that coenzyme Q10 is one of his favorite compounds for the mitochondria, and it is found in sardines.
- Recommends getting coenzyme Q10 from good quality red meat and organ meat, or through supplementation, to act as an electron catcher in the mitochondria, optimizing energy production and reducing oxidative stress.
- Recommends utilizing coenzyme Q10 to support mitochondrial function and the electron transport chain, making hydration more effective.
- Recommends coenzyme Q10 as a runner-up for energy and mitochondrial function, explaining it's an electron carrier in the mitochondrial chain that focuses on the last complex, creating a bigger net to catch electrons and reduce oxidative stress.
- Recommends Coenzyme Q10 for fatigue, stating it's essential for electron transport, ATP regeneration, and reducing oxidative stress, and can be found in organ meats, fatty fish, pistachios, and sesame seeds.
- Mentions Coenzyme Q10 as a micronutrient essential for the complex biological workings of metabolism in the mitochondria.
- Recommends 300-600mg of Coenzyme Q10 for those intermittent fasting or on low carb, to help utilize fuel better, support heart health, and strengthen mitochondrial function by improving the proton gradient.
- Recommends Coenzyme Q10 for people who are fasting or on a ketogenic diet, explaining that it helps fuel the electron transport chain, leading to more efficient energy processing and increased energy during OMAD and the eating period.
- Recommends 300 to 600 milligrams of Coenzyme Q10 during the eating period to help the electron transport chain and utilize food for energy.
- Notes that Coenzyme Q10 is good for mitochondrial health and energy, and there's growing evidence linking it to nitric oxide production, suggesting a supplement if one doesn't get enough from meat.
Dr. Mark Hyman · Coenzyme Q10 · recommends
- Mentions that coenzyme Q10 is important in mitochondrial function and can be a factor in migraines.
- Tried coenzyme Q10 as part of a meticulous effort to address energy and metabolism issues, but implies they no longer use it as they were looking for an easier solution.
- Included coenzyme Q10 in a mitochondrial rejuvenation program to support mitochondrial function.
- States that mitochondria need coenzyme Q10 and that PQQ has been shown to work very well with it.
- States that coenzyme Q10 can be very helpful if fatigue is a significant problem, and is a mitochondrial support for energy recovery.
- Recommends Coenzyme Q10 for better mitochondrial function, lower inflammation, improved insulin sensitivity, and blood sugar, especially for those taking meds or experiencing age-related decline in CoQ10 production.
- Takes Coenzyme Q10, believing it affects the mitochondria and the aging process, even without full scientific confirmation.
- Mentions that coenzyme Q10 was part of the mitochondrial therapy that helped a child with autism improve, and later states it is a key component of mitochondrial supplementation.
- Recommends coenzyme Q10 for mitochondrial repair, stating that high doses of 200 to 400 milligrams a day are needed, spread out with food.
- Recommends Coenzyme Q10 for mitochondrial function, especially for fatigue and heart problems, at doses of 200 to 400 milligrams a day, spread out as 100 milligrams three or four times a day with food, noting its safety and effectiveness for conditions like migraine headaches.
Ben Greenfield · Coenzyme Q10 · neutral
- Discusses Coenzyme Q10 as an ingredient that MitoQ uses in a mitochondria-directed form, noting that standard CoQ10 rarely achieves movement past the cell membrane and into mitochondria.
- Discusses Coenzyme Q10 (CoQ10) in the context of MitoQ Pure being an upgraded form of it.
- Is currently using CoQ10 because any type of a med, including natural ones like red yeast rice extract, can deplete the body's coenzyme Q10 levels, affecting mitochondrial health.
- Is a big proponent of crystal-free coenzyme Q10, explaining that most CoQ10 products have poor absorption due to crystallization, and recommends Pharma Nord's patented process for keeping CoQ10 in solution, which achieves three to ten times higher plasma levels.
- Recommends coenzyme Q10 for lung repair, highlighting its importance for mitochondrial and cardiopulmonary function, especially for those exposed to pollution or who have smoked.
- Takes coenzyme Q10 in the morning for heart disease.
- Is currently using CoQ10 because meds, whether prescription or natural like red yeast rice extract, can strip the body of coenzyme Q10 levels.
- Suggests it is smart to include Coenzyme Q10 for reducing fatigue, referencing a systematic review and meta-analysis.
- Believes Coenzyme Q10 is probably beneficial for 80-year-olds with cardiac issues, but not great for most people, as they are not deficient in it when aging starts around 30-35.
- Recommends a stack of Coenzyme Q10, MitoQ, and PQQ for mitochondrial support, noting that supplements stacking all three are available on Amazon.
Siim Land · Coenzyme Q10 · neutral
- Describes Coenzyme Q10 as a mitochondrial supportive supplement that may increase energy production, but notes there isn't actual lifespan or longevity evidence for it.
- Takes 300 milligrams of Coenzyme Q10 daily as a supplement, noting it helps with energy production, fat oxidization, heart health, and longevity.
Peter Attia · Coenzyme Q10 · neutral
- Notes there isn't good data that Coenzyme Q10 prevents a med Associated muscle symptoms, but doesn't object if patients want to take it because it makes them feel better about taking a med.
Dr. Rhonda Patrick · Coenzyme Q10 · neutral
- A daily dose of coenzyme Q10 reduces blood pressure by about 4mmHg systolic and 3mmHg diastolic in people with type 2 diabetes, potentially lowering cardiovascular risk.
RAL Summary
Members OnlyTier 2 for Circulation
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Blood vessels
Combine with: For cardiovascular support, pair CoQ10 with magnesium (glycinate or taurate), omega-3 fish oil (EPA/DHA), and L-carnitine or PQQ to support mitochondrial function and circulation. Take CoQ10 with a fat-containing meal for better absorption. If the user truly wants an aging and DNA repair focus, stack it with NMN or nicotinamide riboside, resveratrol or pterostilbene, quercetin, vitamin D3/K2, and a B-complex with methylfolate and B12 for DNA synthesis and methylation. Those ingredients target NAD+ and sirtuin pathways more directly. Anyone on meds such as a med, or on meds, should check with a clinician first, since CoQ10 can interact with them.
Possible side effects: No major side effects reported.
Supplement Facts
Coenzyme Q10 200 mg
| Calories | 5 | |
| Total Fat | 0.5 g | |
| Coenzyme Q10 | 200 mg | † |
Other ingredients: Rice Bran Oil, Gelatin, Vegetable Glycerin, Contains <2% of.
Directions: Directions: For adults, take one (1) softgel daily, preferably with a meal.
Barcode (UPC) 030768040017 · Label source: NIH label database · Report a label change
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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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