Jarrow Formulas example brand Swanson Artichoke Leaves, 500 mg, 60 Capsules Review
Swanson Artichoke is a supplement designed to help cleanse your system and support digestive health. The leaf extract contains antioxidant compounds that may aid in gastrointestinal comfort and overall wellness.
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Study, Trial or Testing Result Summary
Members Only15 human studies · 11 improved
Artichoke leaf is taken here at 1500 milligrams a day, which is above the 600 milligrams a day that worked in studies. Note that the studies tested artichoke leaf extract, while this label lists artichoke leaf. A 2024 review of 37 trials with 2509 people with fatty liver disease ranked artichoke leaf extract best of seven natural products for lowering liver enzymes and harmful cholesterol [1]. A 2022 review of five trials with 333 people found lower liver enzymes, cholesterol and blood fats compared with controls [2]. A 2021 review of eight trials also found lower liver enzymes, mostly in people with fatty liver [3]. In a 2018 trial, 100 people with fatty liver who took 600 milligrams daily for 2 months had better liver scans and lower liver enzymes than with a dummy pill [4]. A 2016 trial in 60 patients taking 2700 milligrams daily for 2 months found similar benefits [5]. Not every result agreed. A 2025 review found some liver markers improved while one change was borderline [6]. Most studies were in people with fatty liver, and none reported the share of people who improved. Animal and cell studies are never counted.
See all 15 studies →Hide the studies
- Across 37 trials of 2509 people with fatty liver disease, artichoke leaf extract ranked best among seven natural products for lowering liver enzymes (AST and ALT) and LDL cholesterol.Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of rand…
- Pooling five trials of 333 people with fatty liver disease, artichoke leaf extract lowered liver enzymes (ALT and AST), total cholesterol, LDL cholesterol and triglycerides compared with controls.Therapeutic Potential of Artichoke in the Treatment of Fatty Liver: A Systematic Review and Meta-Analysis.
- Pooling eight clinical trials, artichoke significantly lowered liver enzymes AST and ALT compared with placebo, especially in people with fatty liver disease.The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis.
- In a pooled analysis of adult trials, artichoke lowered the liver markers ALT and alkaline phosphatase, while AST showed a borderline non-significant change, along with modest improvements in weight, blood pressure, cholesterol and insulin resistance.Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence.
- In 140 adults with fatty liver, a multi-ingredient supplement that included artichoke leaf extract taken for 12 weeks reduced liver fat more than placebo (-34 vs -20 dB/m).A new nutraceutical (Livogen Plus®) improves liver steatosis in adults with non-alcoholic fatty liver disease.
- In 100 people with moderately high cholesterol, a combined supplement including artichoke leaf extract for 16 weeks lowered LDL cholesterol but caused no significant change in liver function markers.A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomi…
- In 100 people with fatty liver disease, 600 mg of artichoke leaf extract daily for 2 months improved liver ultrasound findings and lowered liver enzymes (ALT, AST), bilirubin and cholesterol compared with placebo.Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled tria…
- In 60 patients with fatty liver inflammation, 2700 mg of artichoke leaf extract daily for 2 months improved liver enzymes and lowered triglycerides and cholesterol compared with placebo.The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Non…
- In 60 adults with moderately high cholesterol, one daily pill of a combination containing artichoke extract for 8 weeks lowered fatty liver index and waist size compared with placebo, alongside better cholesterol.Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of No…
- In 45 adults with high cholesterol, 4 weeks of a combination supplement with artichoke leaf extract lowered LDL cholesterol but did not change liver function markers.Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderat…
- In 40 people with obesity awaiting weight-loss surgery, 6 weeks of artichoke leaf extract reduced liver fat and liver size compared with placebo, but liver enzymes (especially AST) rose.Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-control…
- In 72 adults with fatty liver inflammation and gallbladder sludge, taking Chophytol (an artichoke leaf extract) three tablets three times daily for one month cleared sludge in 87% of patients, eased pain and normalized liver and lipid blood markers, though the study had no clear placebo group.[Nonalcoholic steatohepatitis and biliary sludge in people with metabolic syndrome].
- In people with fatty liver disease, 12 weeks of artichoke leaf extract taken with a med or vitamin E lowered liver enzymes and liver fat on ultrasound, though there was no placebo group.Read the study on PubMed (34533249) →
- In an uncontrolled study of 311 people with indigestion, 60 days of a multi-herb capsule containing artichoke leaf extract was followed by 6 to 8 percent lower cholesterol and lower liver enzymes in those whose levels started high.[Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the managemen…
- Serum collected from people after taking artichoke leaf extract protected liver cells from fat-related stress in lab tests, but this was an ex vivo study and not a direct health outcome in people.Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorptio…
Review Totals and Summary
Members Only2,852 reviews · 97% positive
Swanson Artichoke Leaves, 500 mg, 60 Capsules has attracted a large and active user base, and real reviews across sites like Amazon, iHerb, Walmart, and Swanson’s own website generally reflect a highly positive experience. The overwhelming majority of users praise its effectiveness, especially in supporting digestion and easing occasional bloating. Many reviewers mention feeling lighter and less sluggish after meals, saying it helps their overall stomach comfort. Some users also note improvements in cholesterol levels or liver function after consistent use, though such claims are usually personal observations rather than guarantees. A recurring highlight among positive feedback is the product's gentle action on the stomach, with several stating that it does not cause harsh side effects or discomfort even after prolonged use. The capsules themselves are often described as easy to swallow, and the dosage is considered convenient for daily routines. Users repeatedly express satisfaction with the price point, feeling the product provides strong value especially compared to more expensive alternatives. In general, the phrase 'does what it says' or similar sentiment comes up a lot, underlining that the capsules meet users' general expectations in quality and effect. Neutral comments often center on subtle benefits—for some, the results are present but not dramatic. A handful of people indicate that while they don’t experience major changes, they still believe the supplement contributes to a more balanced digestive process. Some are unsure whether any improvements are directly due to the product but are willing to keep it in their regimen given its affordability and positive anecdotal reputation. Negative feedback is comparatively rare, but does exist. Disappointment sometimes relates to a perceived lack of noticeable benefits after finishing a bottle, especially among those seeking dramatic effects for specific health goals. A few users mention they either didn’t feel any change or that the supplement didn’t help as hoped with digestive issues. Mild adverse reactions are unusual but have been cited—such as slight stomach upset—though these are generally described as minor. Occasionally, complaints mention the capsules’ size being difficult for those who struggle with swallowing pills, and a few people express skepticism about the potency or authenticity of plant-based supplements in general, without specifically targeting this product’s quality. Overall satisfaction is high across the majority of reviews, with people returning to purchase again and often recommending Swanson Artichoke Leaves, 500 mg, 60 Capsules to friends or family. The combination of gentle effectiveness, reasonable pricing, and consistent quality forms the backbone of its strong reputation. While it isn’t a miracle fix for everyone, it consistently delivers on its core promises for most who try it, making it a favored choice among those looking for natural digestive support.
Biohacker Summary
Members Only6 of 10 recommend it
Seven of the ten panelists spoke about artichoke, and most of them recommend it or use it, though mainly as a food rather than a capsule. The most common reasons are gut health, since several call it a prebiotic fiber that feeds the microbiome, and bile and liver support, which three mention, with one adding gallbladder health and symptoms after gallbladder removal. Others take it for detox, polyphenols, fiber targets, gout, and one used artichoke extract with gentian root for reflux and no longer needs meds for it. Forms named include artichoke hearts eaten at breakfast, whole artichokes, artichoke leaf, extract, and a liver formula that blends artichoke with other ingredients, and the only dose given is 10 grams of inulin a day. One panelist avoids artichoke because it still causes digestive problems for him even after a low FODMAP diet and reintroduction.
See all 8 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Artichoke · recommends
- Mentions that soluble fiber, also called fermentable fiber, is found in artichokes and helps prevent microplastics from being absorbed.
- Suggests building meals around whole-food sources like artichokes to hit the recommended fiber target.
Dr. Mark Hyman · Artichoke · uses
- Eats more artichokes because they are a prebiotic fiber that helps the microbiome.
- States he eats artichokes because he knows they are good for his microbiome.
- Recommends artichoke leaf as an anti-inflammatory phytochemical that can help soothe the gut lining.
- States that he will buy artichokes because they are prebiotic foods that help the microbiome.
- Recommends artichoke hearts as a food that can help boost the detox system.
- Recommends including artichokes in the diet because they are prebiotic foods that help the microbiome.
- Recommends artichoke as a compound that can be helpful for liver health.
- Eats artichokes as side dishes for dinner and mentions them as a prebiotic.
- Includes artichokes in his diet as a prebiotic food, noting they are easy to steam and provide fiber, folate, and detoxification compounds.
- Personally buys artichokes because he knows they have prebiotic fibers and detoxifying compounds.
Thomas DeLauer · Artichoke · recommends
- Recommends artichoke for gallbladder health, stating that cynarin increases bile production.
- Identifies artichoke as one of the best prebiotic sources, offering 10.2g of fiber per 100 calories.
- Recommends artichokes, noting that 10 grams of inulin per day can radically change the gut biome, increasing Fecalibacterium which produces butyrate, fighting inflammation, and improving metabolic markers.
- Recommends artichoke, highlighting its inulin content as one of the best prebiotic fibers that also keeps you satiated.
- Inulin-rich foods include artichokes, asparagus, leeks, and onions.
- Recommends artichokes, stating they contain a long-chain inulin which is the most effective fermentable fiber for short-chain fatty acids and consistently appear in aging-related microbiome research.
- Recommends artichoke as an underrated gut food, noting its inulin acts as a prebiotic fuel for beneficial bacteria and its cynarin boosts bile secretion, aiding fat digestion and detoxification.
- Recommends artichokes as a source of soluble fiber for keto.
- Recommends artichoke for the colon.
- Has incorporated artichokes, including jarred or canned, into his diet for longevity, appetite suppression due to their long-chain inulin's GLP-1 like effect, and benefits for gut bacteria.
Bryan Johnson · Artichoke · uses
- Eats artichoke hearts for breakfast.
Dr. Eric Berg · Artichoke · neutral
- Lists artichoke as a type of fiber that can help increase short-chain fatty acids and activate GLP-1.
- Recommends artichokes as something to try if experiencing symptoms after gallbladder removal.
- Recommends artichoke to help increase bile production.
- Lists artichokes as a natural remedy to get rid of gout.
- Recommends artichokes as a good source of a phytonutrient that can help increase nitric oxide, noting that some people claim to get rid of their gout by taking artichoke.
- Mentions a blend of herbs as a remedy for hepatitis that includes artichoke, with a recommendation to take it three times a day about one and a half hours before eating.
- Dr. Berg lists artichoke as one of the things that increases bile salts.
- Recommends artichoke as a top food to help the body make more bile and reduce gallstones.
- Suggests considering artichokes to support bile production.
- Says that artichoke will majorly increase bile production by stimulating the liver.
Ben Greenfield · Artichoke · uses
- Uses his Liver Complex Formula, which contains NAC, globe artichoke, regular NAC, taurine, and glycine, for bile production and liver support.
- Avoids artichoke because even after following a low FODMAP diet and trying reintroduction, it still causes issues.
- Suggests that consumption of artichokes or a supplement containing artichoke extract appears to have a beneficial effect on Apple B.
- Mentions Artichoke Stem as one of the ingredients in Qualia Mind.
- Ben Greenfield uses artichoke, among other nootropics, to enhance his brain function before recording podcasts.
- Tim occasionally used artichoke extract as part of a CILTEP stack for cognitive enhancement.
- Ben discusses Ciltep, a nootropic with artichoke extract and Coleus Forskohlii, noting its potential to enhance neural function and reduce LDL particle count.
Siim Land · Artichoke · neutral
- Mentions artichoke as very important for stimulating phase one detox.
- Recommends artichokes as a food to hit the daily dose of polyphenols for longevity and anti-aging.
- Notes that artichoke has by far the most polyphenols among vegetables.
- Biohacked his way out of reflux and heartburn using gentian root and artichoke extract, and hasn't needed reflux medications for about eight years.
Dave Asprey · Artichoke · neutral
- Mentions artichokes as a real food source of soluble fiber.
RAL Summary
Members OnlyTier 2 for Liver Health
Three reviews pooling many trials, the largest with 2509 people, found artichoke leaf extract lowered liver enzymes, and this product's daily amount is above the dose that worked [1][4]. Most of the 2852 counted reviews are positive.
Where the evidence disagrees: 2 of the 15 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Liver, Cardiovascular system
Combine with: Not compulsory.
Possible side effects: No major side effects reported in the studies; one small trial saw some liver enzymes rise.
Supplement Facts
Artichoke Leaf 500 mg
| Artichoke Leaf (Cynara scolymus) | 500 mg | † |
Other ingredients: Other ingredients: Gelatin, rice bran, silica, magnesium stearate.
Directions: One capsule one to three times per day with water.
Label source: iHerb · Report a label change
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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