Synchro Joint Rejuvenation + Sleep Set Review

Synchro sells the Joint Rejuvenation + Sleep Set as a bundle of three products: GOLD, a medical grade liposomal turmeric; RE JUVE, a connective tissue regeneration product; and REST, a deep and REM sleep support product. The page is listed under the Bundles category and shows a price of $84.00, down from $120.00, a 30 percent saving, with a subscription option for a 30 day supply delivered monthly and a one-time purchase option. GOLD is described as using a proprietary liposomal nutrient delivery technology that the brand says improves bioavailability six-fold while protecting the turmeric extract from degradation in the gut. The page says that unlike powdered turmeric extracts, GOLD uses an ultra-concentrated CO2 oil extraction that delivers all of turmeric's bioactive compounds. RE JUVE is presented under the heading rebuilding joint smoothness and comfort at the cellular level. The page says it uses BioHyaluronic, a proprietary complex of hyaluronan and phospholipids, which the brand says supports the regeneration of synovial fluid, the material responsible for lubricating joints and maintaining healthy cartilage. The brand claims that by rebuilding synovial fluid and reducing stress on cartilage, RE JUVE allows damaged tissues to rebuild and heal. REST is presented under the heading no melatonin, no sedatives, just better sleep quality. The page explains that the body and brain do most of their repair in deep and REM sleep stages, and says REST uses highly bioavailable forms of magnesium, amino acids and botanical extracts that the brand says are supported by sleep research to relax the nervous system and increase time in deep and REM sleep. The page says this should help people fall asleep more quickly, recover faster and wake up more refreshed. The page also lists HSA and FSA eligibility and offers an installment payment option. Add-on products shown include Hydros, a trace mineral and electrolyte drink, priced at $32.99 for an 8 ounce bottle. The overall listing presents the set as a combined joint and sleep routine for recovery and comfort.[]

Product Focus: Joints and MobilityAlso covers:Brain
Tier ⓘ
Tier 4 · Rank 4
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 4 within Tier 4 for Joints and Mobility; 50 of 69 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
62 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 58,237
Biohacker Mentions
10 of 10

Study, Trial or Testing Result Summary

Members Only21 human studies · 18 improved

6 of these 21 human studies gave the ingredient by injection, not by mouth.

21 human studies18 improved1 no effect17,309 people studied

Most of the evidence for magnesium and joints comes from injections into the joint, not pills. Injected magnesium lowered pain after keyhole knee surgery in pooled trials [1] and in single trials [2][3], and knee injections that included magnesium eased arthritis pain more than a med shots [4]. Those results may not apply to magnesium swallowed as a supplement. For pills, an open study found a mineral tablet with 80 milligrams of magnesium a day eased back and joint pain over 12 months [5], and a small trial found a seawater magnesium blend with algae and pine bark improved knee pain and walking [6]. This product gives far more magnesium than those studies, above the daily recommended limit, so members can take less. Magnesium threonate and lemon balm have no joint studies. L-theanine has been tested for joints only in rats [7]. The one human glycine study used collagen-like peptides, not plain glycine, and did not work against placebo [8]. Apigenin has only been tested in laboratory cells [9]. Animal and cell studies are never counted.

See all 21 studies →Hide the studies

Review Totals and Summary

Members Only58,237 reviews · 90% positive
58,237 reviews · Okendo 52,748 · Besynchro 5,489
90% positive0% neutral10% negative

Buyers are overwhelmingly positive about Synchro Joint Rejuvenation + Sleep Set, mostly describing easier movement and less joint discomfort, with cost the one real complaint. It carries about 52,748 ratings across the stores that sell it. **What buyers say it did for them:** Many describe better mobility and comfort. One long-term user with osteoarthritis says, "I can walk again. I can hike again," and reports being almost pain-free after nearly a year. Another noticed flexibility returning: "I can sit cross-legged on the floor," along with some improved balance, though they note it did not reduce their arthritis pain. A rheumatoid arthritis user cut back on a med, taking Synchro in the morning and a med only at night. Others call it a "game changer" for joints. A user with hip replacements and spinal fusion says it "takes the edge off" everyday arthritis aches, but is clear it does not touch severe pain. One diabetic reviewer credits the Gold product with lowering their blood sugar readings within a day. That is one person's report, not something the other reviews back up. Store summaries mention reduced morning stiffness, and some buyers feeling effects in weeks three to four. **What they complain about:** Price is the main complaint. One 80-year-old on a fixed income says the price has "doubled since I started" and fears they will soon be unable to afford it. Another says they will keep taking it "as long as I can afford it." The brand has acknowledged the pricing concern in its replies. Beyond cost, no negatives appear. **Taste, smell, pill size or form:** The reviews say nothing about these. The store summary notes only that the written feedback centers on the liposomal turmeric Gold product and the Re Juve joint product rather than the bundle as a whole. One reviewer takes two in the morning and one before bed, another two in the morning. **Value for money:** Buyers seem to feel it works well enough to keep buying, but rising cost worries long-term and fixed-income users. Nobody calls it cheap. **Who it seems to suit and who it did not:** It seems to suit people with arthritis, osteoarthritis or RA, and those with lingering injuries, such as a sore thumb or hip flexor, who want better daily comfort and flexibility. Some users have taken it for years, one for about ten. Results vary in speed: one reviewer noticed "subtle changes" after about a week, another saw flexibility return within weeks. It was not described as a fix for severe pain, and one buyer says only surgery solved theirs. Another found it improved flexibility without lessening arthritis pain. Some reviews note the reviewers use Re Juve alongside Synchro, so results may not come from Synchro alone. Anyone on a tight budget should weigh the reported price increases.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Magnesium is the main ingredient, and the panel leans favorable: four of the ten use it themselves, and several more recommend it, mostly for sleep, but also for muscle recovery, stress, blood pressure, bone support, and as an electrolyte. Forms vary: glycinate before bed, threonate for the brain (two take 400 mg of threonate before bed), and one suggests 300 mg before bed. One panelist uses a 30 mg electrolyte drink in the morning for workouts. Doses and forms differ widely, and one panelist cautions that labels can overstate the real magnesium amount when they list the whole compound's weight, and that evidence for sleep is mixed, with some studies finding no real effect. One panelist says magnesium does not fix waking in the night, and several others stay neutral, with no one saying they stopped. Glycine is a smaller ingredient in this product, and the few panelists who spoke on it recommend it for sleep, with two taking 2 grams before bed.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Magnesium · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 14 Oct 2026 · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 30 Sep 2026 · uses · YouTube ↗
      Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
    • 22 Sep 2026 · recommends · Instagram ↗
      Recommends correcting nutrient deficiencies with magnesium.
    • 16 Sep 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
    • 9 Sep 2026 · uses · YouTube ↗
      Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
    • 2 Sep 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
    • 7 Aug 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 7 Aug 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Double Wood Apigenin before bed for sleep.
    • 20 Jul 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 20 Jul 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
  • Dave Asprey · Magnesium · neutral
    • 31 Oct 2026 · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 17 Oct 2026 · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 27 Sep 2026 · recommends · Podcast ↗
      Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
    • 7 Sep 2026 · uses · Instagram ↗
      Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
    • 5 Sep 2026 · Glycine · recommends · YouTube ↗
      Recommends GlyNAC (glycine and NAC together) as very affordable amino acids that he would bet his coffee on if he had to choose just one thing for longevity, as they help the body make glutathione, the master antioxidant.
    • 3 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
    • 29 Aug 2026 · Apigenin · uses · YouTube ↗
      Dave Asprey takes 400 mg of apigenin every night for sleep quality, noting it binds to the same receptor as a med and has 12 randomized trials supporting its effect on sleep quality, despite most products being underdosed.
    • 26 Aug 2026 · Apigenin · recommends · YouTube ↗
      Recommends taking 400 mg of apigenin about 45 minutes before bed, away from the evening meal, to help with sleep by gently turning down the brain's GABA system.
    • 15 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
    • 28 Jul 2026 · recommends · YouTube ↗
      Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
    • 25 Jul 2026 · Apigenin · recommends · YouTube ↗
      Recommends apigenin, highly concentrated in chamomile tea, as a plant compound that directly slows down the demolition crew inside cells, which destroys NAD+.
  • Dr. Eric Berg · Magnesium · neutral
    • 30 Oct 2026 · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 28 Oct 2026 · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing magnesium to restore balance and support healthy blood pressure.
    • 24 Oct 2026 · recommends · Instagram ↗
      Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
    • 24 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
    • 24 Oct 2026 · Glycine · recommends · YouTube ↗
      Recommends Glycine as a cofactor, especially for collagen.
    • 23 Oct 2026 · recommends · Instagram ↗
      Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
    • 23 Oct 2026 · recommends · YouTube ↗
      Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
    • 22 Oct 2026 · recommends · Podcast ↗
      Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
    • 21 Oct 2026 · warns · YouTube ↗
      Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
    • 13 Sep 2026 · Glycine · neutral · Facebook ↗
      Glycine is classified as a non-essential amino acid because the body can make it, but many people are still deficient. It plays a critical role in red blood cell health, DNA and RNA production, bile salts, and glutathione, and is vital for the immune system and quality sleep.
    • 13 Sep 2026 · Glycine · recommends · X ↗
      States that glycine is a powerful anti-aging secret that most people don't know about, and that many people are deficient despite it being a non-essential amino acid.
    • 4 Sep 2026 · Glycine · neutral · Podcast ↗
      Explains that glycine is essential for bile production, glutathione production, and immune function, and that consuming high-quality collagen can help increase glycine intake rather than taking a separate supplement.
  • Ben Greenfield · Magnesium · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 22 Oct 2026 · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 3 Sep 2026 · recommends · YouTube ↗
      Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
    • 25 Aug 2026 · uses · Facebook ↗
      Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
    • 17 Aug 2026 · recommends · Facebook ↗
      Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
    • 15 Aug 2026 · warns · YouTube ↗
      Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
    • 8 Aug 2026 · recommends · YouTube ↗
      Recommends taking magnesium as a co-factor to increase vitamin D absorption.
    • 13 Jun 2026 · neutral · X ↗
      Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
    • 13 Jun 2026 · Apigenin · neutral · X ↗
      Notes a new study indicating that apigenin is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging, and mentions it is found in parsley.
    • 16 May 2026 · Glycine · uses · YouTube ↗
      Mentions Dr. James Di Nicolantonio's claim that glycine, at 5 to 6 grams, can help protect cell membranes against damage from oxidized oils, citing rodent studies.
    • 25 Apr 2026 · Apigenin · uses · YouTube ↗
      States that Nuchido Time Plus includes apigenin from parsley extract, which is a good inhibitor of CD38, an enzyme that wastes NAD+ and drives inflammation.
    • 25 Mar 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
  • Dr. Rhonda Patrick · Magnesium · neutral
    • 29 Oct 2026 · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 29 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 2 Sep 2026 · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 10 Aug 2026 · neutral · Facebook ↗
      States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
    • 10 Aug 2026 · recommends · X ↗
      Recommends considering magnesium to improve mood.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
    • 29 Jun 2026 · neutral · Facebook ↗
      Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
    • 26 Jun 2026 · recommends · Facebook ↗
      Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
    • 15 May 2026 · Glycine · uses · Instagram ↗
      Rhonda takes 2 grams of Glycine before bed for sleep.
    • 15 May 2026 · Apigenin · uses · Instagram ↗
      Rhonda takes 50 mg of Apigenin before bed for sleep.
    • 15 Oct 2025 · Glycine · recommends · Facebook ↗
      Recommends glycine as a better option for a sleep-promoting supplement.
    • 8 Oct 2025 · Glycine · recommends · Facebook ↗
      Recommends Glycine as a sleep supplement that promotes relaxation and reduces nighttime awakenings, offering meaningful improvements to sleep quality.
  • Thomas DeLauer · Magnesium · uses
    • 28 Oct 2026 · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 27 Oct 2026 · Glycine · neutral · YouTube ↗
      Explains that glycine is critical for collagen synthesis, which supports the intestinal wall, and deficiency can slow down the repair process.
    • 26 Oct 2026 · Glycine · recommends · YouTube ↗
      Explains that the body needs roughly 10g more of glycine per day than a typical modern diet provides, and that this deficit can lead to issues with creatine production, connective tissue repair, and sleep. He recommends increasing glycine intake.
    • 24 Oct 2026 · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 14 Oct 2026 · Glycine · uses · YouTube ↗
      Shifts towards glycine when cutting to keep their nervous system calm through the deficit.
    • 12 Oct 2026 · Glycine · neutral · YouTube ↗
      Explains that glycine is a critical amino acid for glutathione production, and the body often has a significant shortage of it, with creatine synthesis consuming a large amount of available glycine.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 6 Oct 2026 · neutral · YouTube ↗
      Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
    • 4 Oct 2026 · Glycine · recommends · YouTube ↗
      Recommends glycine, either from supplements or food sources like bone broth, collagen peptides, and chicken skin, to help build up glutathione.
    • 1 Oct 2026 · recommends · YouTube ↗
      Recommends taking some magnesium glycinate tonight to help calm down and sleep.
    • 1 Oct 2026 · Glycine · recommends · YouTube ↗
      Recommends taking 2 to 3 grams of glycine tonight to help fall asleep.
    • 25 Sep 2026 · neutral · Facebook ↗
      Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
  • Siim Land · Magnesium · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 31 Oct 2026 · Glycine · recommends · Instagram ↗
      Suggests that a higher glycine to methionine ratio appears to preferentially target visceral fat and improve insulin sensitivity.
    • 29 Oct 2026 · Glycine · recommends · Instagram ↗
      Recommends pairing NAC with glycine to support antioxidant activity in your sleep.
    • 26 Oct 2026 · Glycine · recommends · YouTube ↗
      Believes glycine is the best longevity supplement and encourages viewers to learn more about its longevity benefits.
    • 25 Oct 2026 · Glycine · recommends · Instagram ↗
      States that Glycine can be a useful addition for some people for sleep.
    • 21 Oct 2026 · Glycine · uses · YouTube ↗
      Increased his glycine supplementation to 10g a day, noting that it balances methionine and improves blood sugar and glycation.
    • 19 Oct 2026 · Glycine · uses · YouTube ↗
      Personally uses glycine for its health benefits, including glutathione, blood sugar glycation, and potentially sleep, and notes that it appears to have some autophagy benefits by increasing autophagy through its role in methionine metabolism.
    • 14 Oct 2026 · Glycine · neutral · Instagram ↗
      Notes that glycine is one of the most important building blocks for collagen synthesis, making up 30% of collagen, and that 12g of glycine a day is needed for collagen turnover.
    • 13 Oct 2026 · Glycine · uses · Instagram ↗
      Increased his glycine intake as part of an experimental amino acid strategy.
    • 13 Oct 2026 · Glycine · neutral · X ↗
      Retweeted a study stating that 3 g of glycine before bed helped people fall asleep faster and reach deep sleep sooner.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 12 Oct 2026 · Glycine · uses · YouTube ↗
      Takes around 3 to 5 grams of glycine before bed, often mixed with chamomile tea, as human trials have found it can improve subjective sleep quality and shorten the time to fall asleep and enter deep sleep.
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
  • Andrew Huberman · Magnesium · neutral
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 22 Oct 2026 · Apigenin · neutral · Podcast ↗
      Discusses Apigenin as a tool for falling asleep.
    • 7 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 7 Aug 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
    • 7 Aug 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 27 Jul 2026 · uses · YouTube ↗
      Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
    • 20 Jul 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 20 Jul 2026 · recommends · YouTube ↗
      Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
    • 20 Jul 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
    • 20 Jul 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 13 Jul 2026 · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 13 Jul 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Double Wood Apigenin before bed for sleep.
    • 13 Jul 2026 · Glycine · uses · X ↗
      Takes 2 grams of Double Wood Glycine before bed for sleep.
    • 12 Jul 2026 · uses · X ↗
      He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
  • Bryan Johnson · Magnesium · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 22 Oct 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 22 Oct 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
    • 15 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 15 Aug 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 15 Aug 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
    • 4 May 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 4 May 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 4 May 2026 · Apigenin · uses · X ↗
      Takes 50 mg of Apigenin before bed for sleep.
    • 2 May 2026 · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 2 May 2026 · Glycine · uses · X ↗
      He takes 2 g of Glycine before bed for sleep.
    • 2 May 2026 · Apigenin · uses · X ↗
      He takes 50 mg of Apigenin before bed for sleep.
    • 21 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
  • Peter Attia · Magnesium · neutral
    • 1 Jun 2026 · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 1 Jun 2026 · Glycine · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 15 Sep 2025 · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 20 Jul 2025 · Glycine · neutral · YouTube ↗
      Mentions that they also see positive effects of glycine, among other things.
    • 20 Jul 2025 · Apigenin · uses · YouTube ↗
      Takes apigenin, which is a CD38 inhibitor, to effectively increase NAD levels by blocking the enzyme that consumes NAD.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
    • 6 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
    • 7 Jul 2024 · recommends · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
    • 1 Jul 2024 · uses · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
    • 20 Jun 2024 · Glycine · neutral · YouTube ↗
      Mentions that collagen tends to be rich in glycine, among other amino acids.
    • 20 May 2024 · uses · YouTube ↗
      Takes magnesium as a straightforward supplement.
    • 28 Feb 2024 · neutral · YouTube ↗
      Mentions that magnesium intake is often super low and impactful on testosterone levels.
    • 11 Dec 2023 · uses · Facebook ↗
      Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.

RAL Summary

Members OnlyTier 4 for Joints and Mobility

The tier rests on magnesium injected into the knee during or after surgery, not magnesium taken by mouth as in this product, and the few oral studies are small, open or mixed blends, so the evidence for this goal is thin. So it is graded Tier 4, lower than the rules alone gave.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 1 of the 21 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Nervous system

Combine with: For joint support, pair it with omega-3 fish oil (EPA/DHA) for inflammation balance, vitamin D3 with K2 for bone and cartilage health, and collagen peptides with vitamin C for connective tissue. For sleep, magnesium glycinate and glycine can enhance sleep quality. If the user's real goal is better blood flow, add separate circulation-focused supplements such as L-citrulline or L-arginine for nitric oxide production, beetroot extract, nattokinase, or grape seed extract. Consult a healthcare provider first, especially when taking meds or meds.

Possible side effects: No major side effects reported; the injection studies found no added side effects, and high magnesium doses above the daily limit may loosen stools for some people.

Supplement Facts

Magnesium 415 mg · Magnesium L-Threonate 1000 mg · Magnesium Citrate 2180 mg
Supplement Facts
Serving Size ~2 Rounded Teaspoons (7.5g)
Servings Per Container 30
Amount Per Serving% Daily Value
Magnesium415 mg
Magnesium L-Threonate (Magtein®)1,000 mg†
Magnesium Citrate2,180 mg†
L-Theanine1,000 mg†
Glycine2,500 mg†
Lemon Balm Extract (4:1)300 mg†
Apigenin50 mg†
† Daily Value not established.

Other ingredients: Citric Acid, Organic Lemon Flavor, Monk Fruit Extract.

Directions: Add 2 rounded Tsp of Rest to warm water and drink around 45 minutes before bedtime. Botanical extracts can settle, we recommend to stir while drinking.

Label source: Reverseagelab · Report a label change

Show entire label

More joint health products

Members OnlyThe highest ranked for the same goal

Read more

Our articles on this subject

Graded November 8, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.