Thorne Biotin Review
Thorne Biotin is a capsule supplement that provides 8000 mcg of biotin per serving, with one capsule per day listed as the serving size and 60 servings per container. The page describes biotin as a member of the B-vitamin family, sometimes referred to as vitamin H because the German words for hair and skin are haar and haut. It explains that biotin is an essential cofactor for numerous enzymes involved in the metabolism of fats, carbohydrates, and amino acids, so a low level of biotin can negatively affect the body in several ways. The product is presented as a high concentration of biotin that promotes fingernail strength and supports skin, hair, and nerve health, as well as healthy blood sugar metabolism. The page lists groups who may benefit, including an individual taking a med that disrupts biotin synthesis in the gut, anyone with a digestive condition that decreases absorption of nutrients from food, those needing additional support for glucose metabolism, and people with an inherited enzyme deficiency. Listed signs of a low biotin level include dry scaly skin, thin brittle nails, dry brittle hair, hair loss, cracks in the corners of the mouth, a swollen painful tongue, and dry eyes. Thorne states that the formula is built with the scientific rigor the brand is known for, that each ingredient is carefully selected and clinically studied, and that it is tested through multiple rounds of quality control to ensure purity, potency, and consistency. The page notes the product is trusted by health-care practitioners and is third-party tested and certified to verify that what is in the package matches the label and contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. The other ingredients are microcrystalline cellulose, silicon dioxide, calcium laurate, and a hypromellose capsule derived from cellulose. Warnings state that the product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients, that pregnant people should consult a health professional before use, and that biotin supplementation can interfere with certain lab tests, so practitioners should be consulted before having blood drawn. The one-time price is listed at 28 dollars for 60 capsules, or 25.20 dollars with a subscription, and subscription options include delivery intervals from every two weeks up to every four months.
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Study, Trial or Testing Result Summary
Members Only13 human studies · 10 improved
1 of these 13 human studies gave biotin by injection, not by mouth.
Biotin is the only active ingredient here, and the daily amount is well above the 1.25 milligrams that worked in the main trial. In a randomized trial of 105 adults, 1.25 milligrams of plant-derived biotin daily for 90 days reduced hair fall, sped hair growth and improved nails and skin elasticity, with no side effects reported [1]. In 50 people with diffuse hair loss, weekly biotin injections combined with another vitamin reduced hair fall and increased density, but there was no placebo group and this was not an oral capsule [2]. Small case reports found that 10 milligrams daily cleared hair loss within about three months in children taking a seizure medicine [3][4]. Children with an inherited problem processing biotin lost hair when biotin was missing. Two studies of products that mixed biotin with other nutrients reported less hair loss, but they had no control group, so biotin alone cannot be credited [5]. In contrast, among 156 women after weight-loss surgery, 1000 micrograms daily for three months helped only about a quarter of those low in biotin [6]. Much of the support comes from people with low biotin or a medicine-related cause. Animal and cell studies are never counted.
See all 13 studies →Hide the studies
- In 105 adults (97 finished) taking 1.25 mg of plant-derived biotin daily for 90 days, hair fall dropped, hair grew faster by about 0.55 mm a day, and nails and skin elasticity improved, with no side effects reported.The Role of Sesbania grandiflora-Derived Biotin and Bambusa arundinacea-Derived Silica Extracts in Promoting Hair, Skin,…
- In 50 people with diffuse hair loss, six weekly injections of 5 mg biotin with dexpanthenol from either of two brands reduced hair fall and increased hair density, with no placebo group for comparison.Efficacy of intramuscular injections of biotin and dexpanthenol in the treatment of diffuse hair loss: A randomized, dou…
- In women with temporary diffuse hair loss, 180 days of a multi-nutrient supplement that included biotin improved hair loss, volume and density, and did so more fully than a different supplement, but the biotin dose was not stated and there was no placebo group.Comparative evaluation between two nutritional supplements in the improvement of telogen effluvium.
- In 112 people with light diffuse hair loss taking a supplement containing biotin for 12 weeks, hair loss fell by 59% and hair density rose, with 90% of participants perceiving better hair growth and appearance, in an open-label study without a control group.Effectiveness, Tolerability, and Acceptance of a Food Supplement in the Management of Non-Illness-Related Hair Loss and …
- In newborn screening of 246 infants with biotinidase deficiency in Ontario, two children who stopped biotin developed hair loss, along with abnormal gait, skin rashes and developmental delay.Biotinidase deficiency: Spectrum of molecular, enzymatic and clinical information from newborn screening Ontario, Canada…
- Among 156 women who had sleeve gastrectomy, 1000 mcg of biotin daily for 3 months gave little benefit: only 5 of 22 women with biotin deficiency (23%) reported a clear reduction in hair loss, with no significant difference compared with those without deficiency.Hair Loss After Sleeve Gastrectomy and Effect of Biotin Supplements.
- In children on valproic acid, hair loss and skin rash improved after daily oral biotin 10 mg, which was given as a supplement to patients with low biotinidase activity.Low serum biotinidase activity in children with valproic acid monotherapy.
- Infants fed only hydrolysate formula, which contained little biotin, had low blood biotin, and one of them developed hair loss linked to biotin deficiency.Low serum biotin in Japanese children fed with hydrolysate formula.
- In a review of 25 children with short anagen syndrome, a condition where hair does not grow long, biotin alone or with topical minoxidil was reported to be an effective treatment.Short anagen syndrome: A case series and algorithm for diagnosis.
- In five men with male pattern hair loss, a topical solution containing 0.2% biotin along with minoxidil and a med was judged successful for all five over 6 months, with moderately thicker hair and higher hair density in photographs.Read the study on PubMed (32023218) →
- In a study of children taking valproic acid, three girls who lost hair had their hair loss disappear within about 3 months of taking 10 mg of biotin daily.Serum biotinidase activity in children treated with valproic acid and carbamazepine.
- Three children with valproic acid-related hair loss and normal blood biotin levels had their alopecia resolve within 3 months of taking 10 mg of oral biotin daily.The influence of valproic acid and carbamazepine treatment on serum biotin and zinc levels and on biotinidase activity.
- In a family study of people with partial biotinidase deficiency, one child who was not initially given biotin developed hair loss, hypotonia and a skin rash, and these resolved after biotin therapy; the abstract does not give the dose or duration.Partial biotinidase deficiency: clinical and biochemical features.
Review Totals and Summary
Members Only3,881 reviews · 94% positive
Across the stores, Thorne Biotin capsules carry about 1,753 ratings, and the feedback is largely positive. Most buyers credit it with helping their nails and hair, though the store summaries note that results vary and some people see no significant change. **What buyers say it did for them:** Nails are the most common benefit, followed by hair. One buyer wrote, "My nail health is sooo much better, they're stronger & growing like weeds!" Another said, "helps to keep my hair ON my head!" Others reported less shedding, new growth seen by a hair stylist, and compliments on skin after two weeks. Another buyer on a nail strengthener said they "believe the two are helping my nails," so their result may not come from the capsules alone. One nail reviewer still had ridges but said the nails "hardly break." A Vitacost reviewer whose doctor suggested biotin saw a significant reduction in hair loss. **What they complain about:** Complaints are scarce. The one three-star review was not about the product's effect. The buyer worried that the parent company could be Nestle and said they would "dig deeper" before buying more supplements. The Thorne page summary says some customers see no significant change, and a small share of ratings are low, but the written reviews do not describe those experiences. Topic tags on that page include stomach and issues, but no visible text explains them. The Vitacost reviews contain no complaints. **Taste, smell, pill size and form:** Reviewers like the small capsules. One described a "smooth, smaller sized pill that goes down easily," and another called them "Easy to swallow." That same reviewer said they didn't upset their stomach. A Vitacost reviewer said the capsules fit easily into a daily routine. No one mentioned taste or smell. **Value for money:** Price is rarely discussed. One Vitacost reviewer said it is good value, noting that although the serving is two a day, they take only one and still find it worthwhile. Buyers also stress trust in the brand, and one repeat buyer said they would "stick with this brand." One reviewer wrote, "Clean vitamin is important to me and Thorne has best in the market." Another said, "Have tried other brands numerous times, this brand actually does the trick." Vitacost reviewers likewise liked the simple ingredient list and the lack of unnecessary additives. **Who it seems to suit and who it did not:** It seems to suit people with thinning or shedding hair and weak, breaking nails, and people who want a clean, simple formula from a brand they trust. One buyer has had thinning hair since chemotherapy decades ago and is "very pleased." Others use it as part of a hair-thickening routine. Several noted that they had tried other brands first. Timing varied: some saw nail or skin changes within two weeks to a month, while others used it for a couple of months before noting that it "seems to be helping." Those who did not suit it are hard to identify, since written reviews give no detail, apart from the shopper uneasy about corporate ownership and the unnamed buyers who saw no change. Reviews of other product forms that appear on these pages were left out; this summary covers the capsules only.
Biohacker Summary
Members Only6 of 10 recommend it
The panel is split on biotin, with a few recommending it and several urging caution. Reasons for taking it are mostly stronger hair, skin and nails, and some also mention blood sugar and insulin sensitivity; three recommend it for hair and a few more have used it, including one who takes it about twice a week and one who takes a large amount because of personal genetics. The most common caution, from five of the ten, is to stop biotin for several days to a week before blood tests, since it can skew hormone, thyroid and other lab results. Others doubt the hype, saying enough protein may matter more, that biotin alone will not fix hair loss, or that supplementing is unnecessary, and one notes that people on a carnivore diet or eating many raw eggs could run low. Panelists name food sources such as eggs, almonds, salmon and organ meats, and none gave a specific dose or preferred supplement form.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Biotin · neutral
- States that thinning hair often indicates low biotin, which is required to produce keratin for hair, skin, and nails.
- Notes that fungus on nails, identifiable by yellowish discoloration, is an indication of low biotin due to an imbalance in the gut.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including biotin.
- Dr. Eric Berg recommends biotin as a home remedy to help prevent hair loss and regrow hair.
- Mentions that fermented dairy provides vital nutrients such as biotin.
- Emphasizes that biotin is a vital cofactor for collagen absorption and function.
- States that brittle nails are usually caused by a biotin deficiency.
- Recommends getting biotin from a food source rather than a supplement for hair growth.
- Recommends biotin for hair growth, stating it is necessary to make keratin, which improves the hair shaft, makes it strong, and prevents thinning, fragility, and breakage.
- Suggests increasing biotin with a supplement if one has a biotin deficiency.
Thomas DeLauer · Biotin · warns
- Thinks biotin is a little overhyped, suggesting that consuming adequate protein is probably more effective for hair, skin, and nails. He notes that some people might be deficient, especially if consuming a lot of eggs with avidin, but doesn't consider it the 'Mecca of perfect hair'.
- Recommends ensuring sufficient biotin intake, either through diet or supplementation, if hair and nail health is the focus, as it acts as a co-factor for collagen to organize into robust matrixes.
- Takes biotin because her hair had stopped growing for a year, and it has helped her hair grow again.
- Highlights Vitamin B7, or biotin, as beneficial for hair, skin, and nails, but emphasizes its importance for high blood sugar and carb metabolism by increasing insulin receptor sensitivity and glucose tolerance.
- Explains that vitamin B7, also known as biotin, is important for controlling high blood sugar, which plays a role in fat accumulation.
- Warns that 16,000% of the daily value of biotin is overkill and the body will not utilize that much.
- Discusses a Youtheory hair, skin, and nail formula with collagen and biotin, noting that while it's not bad for the price, a powdered supplement form would likely be better.
- States that biotin is super important for synthesizing collagen and is good for hair, skin, and nails.
Dave Asprey · Biotin · neutral
- States that biotin clears out oxalates.
- Lists biotin as an important nutrient for hair health.
- Warns against taking biotin for a substantial period of time before lab testing, especially expensive immune stuff, because it will make results insane and doctors will think you're dying.
- Takes more biotin than others' genetics probably need.
- Takes excessive amounts of biotin due to his genetics, but warns that others may not need the same amount.
- Takes a substantial amount of biotin, believing it helps with oxalate removal, and noticed oxalate detoxing issues like deep pimples when increasing his dose.
- Warns that more people will be harmed by 20 milligrams of biotin a day than will be helped, and he himself developed significant neurological problems from taking 10 milligrams of biotin a day for five weeks.
- Dave's guest mentions that people looking to support their hair often turn to biotin.
- Dave personally takes 20-30 milligrams of biotin, initially for hair growth, and found that after an initial period of 'deep skin things' (dumping symptoms), he now does well on this dose, suggesting it helps with oxalate issues.
Andrew Huberman · Biotin · neutral
- Mentions biotin.
- Discusses biotin-enriched shampoos as a potential way to offset dryness and brittleness from ketoconazole, noting that while sufficient biotin is important, it's unclear if these shampoos significantly enhance biotin incorporation into hair.
Siim Land · Biotin · neutral
- Siim Land's company has published papers and filed patents for improvement in mitochondria in the skin using their core mitochondrial approach and other things like biotin.
- Mentions biotin as a nutraceutical with anti-thrombotic potential, increasing cyclic GMP.
- Recommends Biotin (Vitamin B7) for maintaining youthful skin, hair, and nails.
Dr. Rhonda Patrick · Biotin · warns
- Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
- She occasionally uses biotin for hair and nails, meaning about twice a week.
Peter Attia · Biotin · warns
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
- Finds it silly to suggest that one needs to supplement biotin levels.
- Warns that biotin alone will not substantially improve female or male pattern hair loss, but it can make existing hairs stronger and needs to be coupled with other effective treatments.
Ben Greenfield · Biotin · recommends
- Recommends biotin (Vitamin B7) for supporting keratin production and strengthening hair, noting it can be found in eggs, almonds, and salmon.
- Warns that biotin could mess with a blood test and make certain lab tests unreliable if used leading up to the test.
- Warns of biotin deficiency on a carnivore diet, as it is low in meat but found in organ meats like liver, heart, kidney, and thymus glands.
- Notes that Kino Octane contains biotin and mentions that some men deficient in biotin notice a bump in testosterone when taking it.
- Mentions that the individual's microbes are producing good vitamins, including thiamine, biotin, and menaquinone (vitamin K2).
- Lists Biotin as a micro-nutrient that, if deficient, can hinder fat loss.
- Mentions biotin as one of the most significant micronutrients whose deficiency can prevent fat loss.
- Notes that the user has a lower likelihood of gut bacteria producing biotin, which can be found in foods like nuts and seeds.
- Used to consider taking enough Biotin for postpartum hair loss, but realized it was a hormonal issue that settled down on its own.
- Recommends biotin as a foundational nutrient for healthy methylation.
Dr. Mark Hyman · Biotin · recommends
- Recommends supplementing with biotin for hair follicle health and growth.
- Includes biotin as part of the IV drip protocol for detoxification.
- Mentions biotin as one of many nutrients that can be helpful for insulin resistance.
- Recommends biotin as helpful for insulin resistance and regulating blood sugar.
- Notes that biotin was among the compounds identified to regulate inflammation in a clinical trial.
- States that biotin is critical for regulating blood sugar.
- Notes that biotin can play a big role in hair loss, as it's made by gut bacteria, so a poor microbiome might lead to insufficient biotin production.
- Recommends ensuring adequate intake of biotin (B7), found in organ meats, for healthy hair, skin, and nails, noting that gut bacteria also produce it.
- States that biotin can be helpful for some people with hair problems, especially when biotin levels are low, which can lead to breaking hair and nails.
- Dr. Hyman mentions biotin as an important nutrient for hair and nails, noting that low levels can lead to breaking hair and nails, and it is produced by gut bacteria.
Bryan Johnson · Biotin · neutral
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
RAL Summary
Members OnlyTier 2 for Hair Growth
A randomized trial of 105 adults found that daily biotin reduced hair fall and sped growth [1], 10 of 13 human studies showed improvement, and 94% of 3891 reviews are positive, which meets the second tier.
Where the evidence disagrees: 3 of the 13 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Integumentary system (hair, skin and nails)
Combine with: For hair support, biotin pairs well with zinc, iron (only if ferritin is low), vitamin D, collagen peptides, silica, and saw palmetto or marine collagen complexes. Vitamin C aids collagen synthesis, and omega-3s support scalp health. If the underlying goal is cellular and DNA repair, choose different agents such as NMN or NR with TMG, resveratrol or pterostilbene, CoQ10 or ubiquinol, alpha-lipoic acid, PQQ, quercetin, fisetin, and a B-complex with methylfolate and B12 for methylation support. Note that high-dose biotin can interfere with lab tests such as thyroid panels and troponin, so stop it several days before bloodwork and tell your clinician.
Possible side effects: No side effects were reported in the main trial, and one reviewer said it did not upset their stomach; a store page tags stomach issues, but no reviews explain this.
Supplement Facts
Biotin 8000 mcg
| Biotin | 8,000 mcg |
Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Calcium Laurate, Silicon Dioxide.
Directions: Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Label source: Reverseagelab · Report a label change
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