Thorne CoQ10 Review
Thorne CoQ10 is a supplement that supplies coenzyme Q10 in the form of ubiquinone, presented as a proprietary, optimally absorbed, lipid-based and non-crystalline form. The page describes CoQ10 as a nutrient found in the mitochondria of cells, where it provides support against oxidative stress and plays an important role in the body's production of cellular energy. The product is positioned to support cardiovascular and neurological health, cellular energy production and healthy aging. Each serving is one gelcap, and each container holds 60 gelcaps, with each gelcap providing 100 mg of coenzyme Q10. The page lists the other ingredients as flax seed, bovine gelatin, purified water and glycerin from a vegetable source for the gelcap, lycopene and turmeric gel cap, linoleic acid and soy monoglycerides. The page explains that CoQ10 is particularly supportive for the cells of the heart, liver, brain, kidney and muscles. It notes that the level of CoQ10 in the body declines with age and can be depleted by certain medications, which is the reason given for supplementation. Listed benefits include support for the body's energy level and exercise stamina, support for a healthy heart including normal heart rhythm, blood vessel function and healthy blood pressure, promotion of healthy aging through enhanced mitochondrial function, and support for a healthy inflammatory response. The page also says the product helps protect against oxidative stress by enhancing the activity of glutathione, which it describes as the body's master antioxidant. The absorption claim is central to the product. Thorne states that its lipid-based, non-crystalline form is enhanced over other preparations including dry powder, oil, nanoparticle and liposomal forms. The brand says the formula is scientifically developed, that each ingredient is selected, clinically studied and tested through multiple rounds of quality control, and that the product is trusted by health-care practitioners. Testing is described as third-party testing and certification to confirm that contents match the label and that the product contains no unsafe levels of heavy metals, pesticides or microorganisms. The FAQ section notes the NSF Contents Certified mark. Warnings on the page state that the product is contraindicated for anyone with a history of hypersensitivity to its ingredients. Because the monoglycerides are derived from soy, the page says they contain no soy protein. Pregnant users are advised to consult a health-care practitioner before use. The page reports no known adverse interactions at publication date. The page lists related Thorne products including Red Yeast Rice with CoQ10, Berberine, Omega-3 with CoQ10 and Men's Multi 50+. Pricing shows $53 for 60 gelcaps, or $47.70 with a subscription at 10 percent off.
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Study, Trial or Testing Result Summary
Members Only25 human studies · 19 improved
This product gives coenzyme Q10 at 200 mg a day, a full dose compared with studied amounts. In a four-year trial of 403 older adults low in selenium, 200 mg a day with selenium raised a selenium protein linked to longer telomeres, less inflammation, better quality of life and lower death rates [1]. In 100 healthy trained adults, 200 mg a day for two weeks lowered exercise-related oxidative damage, including DNA damage, compared with placebo [2]. In 40 patients with early sepsis, 200 mg a day for a week lowered inflammation and oxidative damage markers [3]. In 33 healthy adults, 50 or 150 mg a day for 12 weeks reduced wrinkles and fine lines but did not change skin hydration [4]. A review of 20 trials in 2,617 women with ovarian aging found coenzyme Q10, at about 30 mg a day for 3 months, worked best among antioxidants for egg retrieval and pregnancy rates [5]. However, in 40 healthy older adults, 400 mg a day for 12 weeks raised blood levels but did not improve muscle energy use, blood sugar control, fitness or body composition [6]. No study measured a reversal of biological age. Animal and cell studies are never counted.
See all 25 studies →Hide the studies
- Across 20 trials of 2617 women with ovarian aging, antioxidants raised egg retrieval and pregnancy rates, and coenzyme Q10 worked best, at about 30 mg a day for 3 months before ovarian stimulation.Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.
- In 403 older adults low in selenium, four years of coenzyme Q10 (200 mg a day) plus selenium raised selenoprotein P, which was linked to longer telomeres, less inflammation, better quality of life and lower death rates.Selenoprotein P increases upon selenium and coenzyme Q10 supplementation and is associated with telomere length, quality…
- In 124 patients with acute viral heart inflammation, coenzyme Q10 lowered inflammation and oxidative stress markers, and combining it with trimetazidine worked better than either alone.Combination Therapy With Coenzyme Q10 and Trimetazidine in Patients With Acute Viral Myocarditis.
- In 100 healthy trained adults, two weeks of ubiquinol (200 mg a day) lowered exercise-induced oxidative damage markers, including DNA damage (8-OHdG), compared with placebo.Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A ra…
- In 73 people with chronic fatigue syndrome, 8 weeks of coenzyme Q10 (200 mg a day) plus NADH reduced fatigue versus placebo, raised cellular energy (ATP) and NAD+/NADH, and lowered lipid peroxides.Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?
- In 50 elderly patients having aortic valve surgery, ubiquinol (400 mg a day) from a week before to 5 days after surgery blunted the drop in blood coenzyme Q10 and the rise in a heart injury marker (troponin I) versus placebo.Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects.
- In 49 adults with diabetic nerve damage, 12 weeks of ubiquinone (400 mg a day) improved symptoms and nerve conduction and lowered lipid peroxidation versus placebo.The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study.
- In 40 patients with early sepsis, 200 mg of coenzyme Q10 daily for 7 days lowered levels of an inflammation marker (TNF-alpha) and an oxidative damage marker (MDA) and was linked to lower in-hospital deaths than the control group.Coenzyme Q10 improves the survival and reduces inflammatory markers in septic patients.
- In 40 healthy older adults (about 74 years old), 400 mg of coenzyme Q10 daily for 12 weeks raised blood levels but did not change muscle mitochondrial function, blood sugar control, fitness or body composition compared with placebo.Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults.
- In 36 patients with antiphospholipid syndrome, 200 mg of ubiquinol daily for 1 month improved blood vessel function and lowered markers of inflammation, clotting risk and oxidative stress compared with placebo.Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile: A Randomized, Placebo-Controlled Trial.
- In 33 healthy adults, 12 weeks of daily water-soluble coenzyme Q10 (50 or 150 mg) reduced wrinkles and fine lines and improved skin smoothness compared with placebo, but did not change skin hydration.The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controll…
- In 23 a med-treated adults with type 2 diabetes and poor artery function, 200 mg of coenzyme Q10 daily for 12 weeks improved blood vessel widening compared with placebo, while oxidative stress markers did not change.Read the study on PubMed (19228872) →
- In 23 moderately trained healthy men, 90 mg of coenzyme Q10 daily for 8 weeks did not improve maximal oxygen uptake, exercise workload, or exercise-related oxidative stress compared with placebo.Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans.
- In 21 sedentary young men, 200 mg of coenzyme Q10 daily for 4 weeks raised blood levels but did not reduce muscle damage or oxidative stress after hard exercise compared with placebo.Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men.
- In 10 people with juvenile fibromyalgia, 100 mg of ubiquinol daily for 12 weeks improved fatigue scores and blood cholesterol levels.Increased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia an…
- In 10 older men taking 200 mg of ubiquinol daily with a meal for 2 weeks, blood levels of Coenzyme Q10 rose, but markers of oxidative stress and cell energy did not change.Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men.
- In gas and oil industry workers with oxidative stress and impaired heart and nerve function, a short course of a coenzyme Q10-based supplement improved cardiovascular and psycho-emotional measures and normalized markers of oxidative stress in white blood cells.Coenzyme Q10-containing composition (Immugen) protects against occupational and environmental stress in workers of the g…
- In 41 volunteers, 2 months of a marine collagen and antioxidant blend including coenzyme Q10 improved skin elasticity, sebum production and dermal ultrasound markers, with no change in glutathione or coenzyme Q10 levels.Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidan…
- In 36 hemodialysis patients, coenzyme Q10 for 6 months lowered some oxidative stress markers (protein oxidation products and the oxidized form of CoQ10) and also lowered antioxidant capacity, and the effects reversed after stopping.Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients.
- In 30 young adults with type 1 diabetes and kidney complications, adding coenzyme Q10 to standard treatment lowered oxidative damage, improved antioxidant activity and reduced blood sugar markers.Effect of combination therapy with coenzyme Q10 on functional and metabolic parameters in patients with type 1 diabetes …
- In 10 children with trisomy 21 given 10 mg of ubiquinol-10 per kg of body weight daily for 3 months, the blood ratio of active to total coenzyme Q10 rose into the normal range, correcting a pro-oxidant imbalance; there was no placebo group.Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.
- In 53 healthy men, 150 mg of ubiquinol daily for 14 days significantly lowered a blood enzyme linked to oxidative stress and inflammation, while liver enzyme AST was unaffected.Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.
- In aged rat hearts and human atrial tissue, coenzyme Q10 pretreatment restored recovery of contractile function after stress that was reduced with age.Coenzyme Q10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in h…
- Skin cells from older donors showed weaker mitochondrial energy function than those from younger donors, and topically applied coenzyme Q10 improved mitochondrial function in skin.Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.
- In people with Down syndrome, prolonged coenzyme Q10 treatment reduced the share of cells with the highest levels of oxidized DNA bases in an age-specific way, though overall DNA oxidation was not clearly changed.Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation.
Review Totals and Summary
Members Only1,352 reviews · 92% positive
Across the stores, Thorne CoQ10 shows 1349 ratings in total, and the themes below come from the written reviews that could be read on the product page. Only five short reviews were visible, so these points are specific but few. Trust in the brand is the most common theme. One reviewer says they trust the company because of its reputation. Another describes Thorne supplements in general as all being great quality, and treats this CoQ10 as one more product in a line they already rely on. Quality is the central praise. One reviewer calls the product great and high quality, and says both they and their husband added it to their daily routine, so it seems to suit sharing within a household. A short review simply calls it great and adds no further detail. The page's site-level summary says customers praise its quality and effectiveness for energy, heart health and cell health, and that the ingredients are seen as clean and clinically proven. Energy and exercise recovery come up in personal accounts. One reviewer uses CoQ10 together with acetyl L-carnitine and alpha lipoic acid as go-to supplements. They report more physical energy, especially after working out at the gym, and faster recovery after intense exercise. This suggests the product appeals to people who train regularly and already take a small stack of supplements. On the complaint side, the main point about the product is size. The site-level summary notes that some customers find the capsules and pills too large. That summary describes it as the main physical complaint across the wider rating base, though none of the five visible reviews raises it directly. One of the five reviews is critical of the shopping experience rather than the supplement. That buyer says the Thorne website was the worst part and that they will buy from stores instead. This is about the online channel, not the quality of the product. Of the 165 ratings on the Thorne.com page, 15 are one or two stars. So a small group of buyers is clearly dissatisfied, but the written reviews that could be read do not explain those low ratings. The summaries say nothing specific about taste, dosing details or price and value, so none of that can be reported. No reviews of other forms such as gummies, capsules or powder were identified, so nothing had to be left out on that account. Overall, buyers who wrote in are mostly positive. They value the brand's reputation, the quality and clean ingredients, and the energy and recovery benefits they feel. The reservations are the softgel's size and the frustrations with the website. Because the written reviews are brief, it is sensible to read the generally high star distribution alongside the small amount of detail they give.
Biohacker Summary
Members Only8 of 10 recommend it
Coenzyme Q10 is the main ingredient, and the panel leans favorable: of the eight who spoke, three say they take it daily, and several more recommend it, mainly to support the mitochondria (the cell's energy producers), energy, fatigue, and heart health. Doses mentioned run from 100 to 400 mg, with 300 mg a day a common choice, and one panelist says some people go up to 1200 mg. Two prefer the ubiquinol form, one suggests taking it with a fatty meal at dinner, one favors a crystal-free form for better absorption, and one pairs it with PQQ. Several take it because meds can lower the body's own levels, though one panelist says there isn't good data that it prevents med-related muscle symptoms and another says there is no real evidence it extends lifespan. One panelist tried it and then moved on to an easier solution, and another stopped using it at one point in 2024.
See all 9 biohackers →Hide the biohackers
Dr. Eric Berg · Coenzyme Q10 · neutral
- Mentions that grass-fed liver has coenzyme Q10.
- Recommends that anyone with a med prescription should also take coenzyme Q10, specifically the ubiquinol form, to support heart and muscle function.
- Notes that Merck filed a patent for a med combined with coenzyme Q10, but never added it back into the formula, and that major heart organizations do not recommend taking coenzyme Q10 alongside meds.
- Recommends taking coenzyme Q10, specifically ubiquinol, to prevent the side effects of meds, especially for those experiencing muscle weakness, pain, fatigue, or exercise intolerance. He suggests a dose of 200 to 400 mg, or even up to 1200 mg a day for some individuals.
- Mentions that coenzyme Q10 supports the heart and mitochondria as a powerful antioxidant, and meds deplete its production.
- States that coenzyme Q10 has been known to help people with fibromyalgia feel better.
- Recommends Coenzyme Q10, especially for those on meds, as it's a key nutrient for energy in the mitochondria and works with vitamin E and selenium, and suggests taking it at lunch with a meal.
- Recommends coenzyme Q10 as a remedy for long COVID.
- Mentions that meds block coenzyme Q10 and refers to another video where he discusses it.
- Dr. Berg highlights coenzyme Q10 as a key essential nutrient for mitochondria in the heart, and recommends taking it if on meds, as meds deplete this nutrient.
Dave Asprey · Coenzyme Q10 · uses
- States he takes 300 mg of Coenzyme Q10 every day for 20 years because it is necessary for mitochondria to function and is important for longevity, noting that meds lower it.
- Recommends coenzyme Q10 (CoQ10) to support mitochondria, as it helps generate energy and fights oxidative stress.
- Mentions that there are methylation genes for Coenzyme Q10 that convert it to ubiquinol.
- Suggests taking Coenzyme Q10 to optimize mitochondria.
- Mentions Coenzyme Q10 as something that can change blood viscosity, alongside sunlight and earthing.
- Includes Coenzyme Q10 as a helpful addition to a med protocol.
- Used to give his dog coenzyme Q10 for mitochondrial function.
- Dave Asprey mentions Coenzyme Q10 as something one might take to boost ATP production.
- Dave Asprey mentions that Coenzyme Q10 is a big deal for a lot of people regarding energy.
- Mentions Coenzyme Q10 as one of the micronutrients that can help protect the glycocalyx.
Andrew Huberman · Coenzyme Q10 · uses
- Personally takes Omega-3 and Coenzyme Q10 every day, noting they are known to support cardiovascular health, cellular health and energy, and brain health.
- Personally takes coenzyme Q10 every day, noting it supports cardiovascular health, cellular health, energy, and brain health.
- Discusses a study where probiotics, magnesium orotate, and coenzyme Q10 showed a short-term improvement in symptoms of major depression.
- Discusses Coenzyme Q10 as a fertility supplement.
- Recommends Coenzyme Q10 at 100 to 400 milligrams per day, taken with a meal containing fat, ideally dinner, to improve sperm quality by supporting mitochondrial health, which is vital for sperm formation and fertilization.
- States that coenzyme Q10 should be taken with food.
- Mentions Coenzyme Q10 as a tool for fertility.
- Andrew Huberman says he personally takes AG1's new Omega-3 Coenzyme Q10 product every day, noting that Omega-3 and Coenzyme Q10 are known to support cardiovascular health, cellular health, energy, and brain health.
- Andrew Huberman notes that some papers suggest coenzyme Q10 might be beneficial for egg quality.
Thomas DeLauer · Coenzyme Q10 · uses
- States that coenzyme Q10 is one of his favorite compounds for the mitochondria, and it is found in sardines.
- Recommends getting coenzyme Q10 from good quality red meat and organ meat, or through supplementation, to act as an electron catcher in the mitochondria, optimizing energy production and reducing oxidative stress.
- Recommends utilizing coenzyme Q10 to support mitochondrial function and the electron transport chain, making hydration more effective.
- Recommends coenzyme Q10 as a runner-up for energy and mitochondrial function, explaining it's an electron carrier in the mitochondrial chain that focuses on the last complex, creating a bigger net to catch electrons and reduce oxidative stress.
- Recommends Coenzyme Q10 for fatigue, stating it's essential for electron transport, ATP regeneration, and reducing oxidative stress, and can be found in organ meats, fatty fish, pistachios, and sesame seeds.
- Mentions Coenzyme Q10 as a micronutrient essential for the complex biological workings of metabolism in the mitochondria.
- Recommends 300-600mg of Coenzyme Q10 for those intermittent fasting or on low carb, to help utilize fuel better, support heart health, and strengthen mitochondrial function by improving the proton gradient.
- Recommends Coenzyme Q10 for people who are fasting or on a ketogenic diet, explaining that it helps fuel the electron transport chain, leading to more efficient energy processing and increased energy during OMAD and the eating period.
- Recommends 300 to 600 milligrams of Coenzyme Q10 during the eating period to help the electron transport chain and utilize food for energy.
- Notes that Coenzyme Q10 is good for mitochondrial health and energy, and there's growing evidence linking it to nitric oxide production, suggesting a supplement if one doesn't get enough from meat.
Dr. Mark Hyman · Coenzyme Q10 · recommends
- Mentions that coenzyme Q10 is important in mitochondrial function and can be a factor in migraines.
- Tried coenzyme Q10 as part of a meticulous effort to address energy and metabolism issues, but implies they no longer use it as they were looking for an easier solution.
- Included coenzyme Q10 in a mitochondrial rejuvenation program to support mitochondrial function.
- States that mitochondria need coenzyme Q10 and that PQQ has been shown to work very well with it.
- States that coenzyme Q10 can be very helpful if fatigue is a significant problem, and is a mitochondrial support for energy recovery.
- Recommends Coenzyme Q10 for better mitochondrial function, lower inflammation, improved insulin sensitivity, and blood sugar, especially for those taking meds or experiencing age-related decline in CoQ10 production.
- Takes Coenzyme Q10, believing it affects the mitochondria and the aging process, even without full scientific confirmation.
- Mentions that coenzyme Q10 was part of the mitochondrial therapy that helped a child with autism improve, and later states it is a key component of mitochondrial supplementation.
- Recommends coenzyme Q10 for mitochondrial repair, stating that high doses of 200 to 400 milligrams a day are needed, spread out with food.
- Recommends Coenzyme Q10 for mitochondrial function, especially for fatigue and heart problems, at doses of 200 to 400 milligrams a day, spread out as 100 milligrams three or four times a day with food, noting its safety and effectiveness for conditions like migraine headaches.
Ben Greenfield · Coenzyme Q10 · neutral
- Discusses Coenzyme Q10 as an ingredient that MitoQ uses in a mitochondria-directed form, noting that standard CoQ10 rarely achieves movement past the cell membrane and into mitochondria.
- Discusses Coenzyme Q10 (CoQ10) in the context of MitoQ Pure being an upgraded form of it.
- Is currently using CoQ10 because any type of a med, including natural ones like red yeast rice extract, can deplete the body's coenzyme Q10 levels, affecting mitochondrial health.
- Is a big proponent of crystal-free coenzyme Q10, explaining that most CoQ10 products have poor absorption due to crystallization, and recommends Pharma Nord's patented process for keeping CoQ10 in solution, which achieves three to ten times higher plasma levels.
- Recommends coenzyme Q10 for lung repair, highlighting its importance for mitochondrial and cardiopulmonary function, especially for those exposed to pollution or who have smoked.
- Takes coenzyme Q10 in the morning for heart disease.
- Is currently using CoQ10 because meds, whether prescription or natural like red yeast rice extract, can strip the body of coenzyme Q10 levels.
- Suggests it is smart to include Coenzyme Q10 for reducing fatigue, referencing a systematic review and meta-analysis.
- Believes Coenzyme Q10 is probably beneficial for 80-year-olds with cardiac issues, but not great for most people, as they are not deficient in it when aging starts around 30-35.
- Recommends a stack of Coenzyme Q10, MitoQ, and PQQ for mitochondrial support, noting that supplements stacking all three are available on Amazon.
Siim Land · Coenzyme Q10 · neutral
- Describes Coenzyme Q10 as a mitochondrial supportive supplement that may increase energy production, but notes there isn't actual lifespan or longevity evidence for it.
- Takes 300 milligrams of Coenzyme Q10 daily as a supplement, noting it helps with energy production, fat oxidization, heart health, and longevity.
Peter Attia · Coenzyme Q10 · neutral
- Notes there isn't good data that Coenzyme Q10 prevents a med Associated muscle symptoms, but doesn't object if patients want to take it because it makes them feel better about taking a med.
Dr. Rhonda Patrick · Coenzyme Q10 · neutral
- A daily dose of coenzyme Q10 reduces blood pressure by about 4mmHg systolic and 3mmHg diastolic in people with type 2 diabetes, potentially lowering cardiovascular risk.
RAL Summary
Members OnlyTier 2 for Healthy Aging
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cellular energy and metabolism, Immune system, Skin, Reproductive system, Muscular system
Combine with: CoQ10 (ubiquinone) supports mitochondrial electron transport and acts as a fat-soluble antioxidant, which fits the cellular aging goal. Note that it is not a direct DNA repair agent, and its evidence is strongest for mitochondrial and cardiovascular support. Pair it with NAD+ precursors such as NMN or nicotinamide riboside to support mitochondrial energy metabolism and sirtuin activity. Add PQQ to promote mitochondrial biogenesis. Trans-resveratrol or pterostilbene offer complementary antioxidant and longevity-pathway support. Alpha-lipoic acid and glutathione (or NAC) help recycle antioxidants and reduce oxidative stress. Omega-3 fish oil supports membrane health and lowers inflammation. Magnesium and B vitamins act as cofactors in cellular energy production. Take CoQ10 with a meal containing fat for best absorption. If you take meds or meds, consult your doctor first, as CoQ10 may interact with them.
Possible side effects: No major side effects reported in the studies; some buyers find the softgels too large.
Supplement Facts
Coenzyme Q10 100 mg
| Calories | 10 | |
| Total Fat | 1 g | |
| Coenzyme Q10 | 100 mg | † |
Other ingredients: Gelatin (bovine), Purified Water, Glycerin (vegetable source), Lycopene and Turmeric (color) Gelcap, Conjugated Linoleic Acid, Flaxseed Oil, Soy Monoglycerides.
Directions: Take 1 gelcap one to two times daily or as recommended by your health-care practitioner.
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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