Thorne Pantethine Review
Pantethine is an active form of pantothenic acid, or vitamin B5, and is a vital component of coenzyme A, a cofactor in dozens of enzymatic reactions, including reactions involved in fat and carbohydrate metabolism. According to this page, pantethine appears to facilitate the metabolism of fatty acids by activating coenzyme A, which promotes carnitine's transport of fatty acids into the mitochondria and subsequent intra-mitochondrial oxidation of those fatty acids. The page states that pantethine supplementation has been found to support good cardiovascular health and that increases in beneficial HDL cholesterol and apolipoprotein A1 have been associated with pantethine supplementation. It also describes pantethine as an anti-stress vitamin because it supports healthy adrenal cortex function and hormone synthesis, particularly during times of stress. Clinical trials are described as suggesting that, because its biochemical configuration is closer to coenzyme A than pantothenic acid, pantethine might have more benefit than pantothenic acid. The presence of pantethine is said to facilitate the body's production of apolipoprotein A1, the major protein component of HDL, which promotes the removal of cholesterol from tissues to the liver for excretion. The page also notes that pantothenic acid deficiency can result in adrenal atrophy, characterized by increased fatigue, sleep disturbances, nausea, and abdominal discomfort. The product is listed with a serving size of 1 capsule, 60 servings per container, and 250mg of Vitamin B5 (Pantethine) per serving. The other ingredients are calcium laurate, hypromellose capsule, leucine, magnesium citrate, and silicon dioxide. Warnings on the page state that the product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients, that pregnant users should consult a health professional before using it, and that there are no known adverse interactions or contraindications at publication date. The page carries the standard statement that these claims have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. The product is currently sold out, with inventory on the way, and the page offers a notify-me option for when it becomes available. The listing is sold by Better Health International, and the page shows the Thorne brand and SKU TH70603.
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Study, Trial or Testing Result Summary
Members Only23 human studies · 22 improved
1 of these 23 human studies gave pantethine by injection, not by mouth.
Pantethine is the only active ingredient here. The label gives 750 milligrams a day, which is above the 500 milligrams that worked in studies. Most human studies found that it modestly lowers cholesterol. In a placebo-controlled trial of 120 adults at low to moderate heart risk who were following a healthy diet, 600 milligrams a day for 8 weeks and then 900 milligrams for 8 weeks lowered total cholesterol by 3% and bad cholesterol by 4% more than placebo [1]. A placebo-controlled trial of 32 adults who qualified for meds used the same plan. It lowered total, bad and other harmful cholesterol, and bad cholesterol fell 11% from the start [2]. In adults with moderately high triglycerides, 8 weeks of pantethine cut triglycerides by 16.5%, although coenzyme A lowered them more [3]. A large survey of 1045 people with high cholesterol who took about 900 milligrams a day found better blood fat levels and very good tolerability [4]. An older controlled study of 29 people with high blood fats found that 900 milligrams a day lowered total and bad cholesterol by 13.5% in one patient group [5]. In 182 heart patients with stable angina, pantethine improved blood fats, and 500 milligrams a day was recommended for those with clearly high blood fats [6]. The studies did not report what share of people improved. Animal and cell studies are never counted.
See all 23 studies →Hide the studies
- In 105 adults with moderately high triglycerides given pantethine 600 units a day for 8 weeks, triglycerides fell 16.5% from baseline, but coenzyme A lowered them more than pantethine did.Efficacy and tolerability of coenzyme A vs pantethine for the treatment of patients with hyperlipidemia: A randomized, d…
- In 120 low-to-moderate heart risk adults on a healthy diet, pantethine (600 mg a day for 8 weeks then 900 mg for 8 weeks) lowered total cholesterol by 3% and LDL cholesterol by 4% more than placebo.Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein chol…
- In 32 adults eligible for meds, pantethine (600 mg a day for 8 weeks then 900 mg for 8 weeks) lowered total, LDL and non-HDL cholesterol more than placebo, with an 11% LDL drop from baseline.Read the study on PubMed (24600231) →
- In a randomized placebo-controlled crossover study of 10 people with high cholesterol, 28 days of pantethine significantly lowered total cholesterol in plasma and platelets and shifted platelet fats in a favorable direction.Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia.
- In 182 patients with coronary heart disease and stable angina, pantethine and calcium pantothenate both had favourable effects on lipid metabolism and heart function, and pantethine at 500 mg a day was recommended for patients with clear high blood fats.[Therapeutic efficacy of pantothenic acid preparations in ischemic heart disease patients].
- In 48 people with moderately high cholesterol, pantethine 600 mg plus probucol for 8 weeks lowered total cholesterol but also lowered HDL (good) cholesterol and did not improve the atherogenic index, and pravastatin worked better.Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate hyperchole…
- In 29 people with high blood fats, pantethine 900 mg a day for 8 weeks cut total and LDL cholesterol by 13.5% in one patient type and lowered triglycerides by about 30% in some groups.Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoprot…
- In 27 diabetics with abnormal blood fats compared across three drugs for 6 months, pantethine 600 mg a day lowered triglycerides by 37.7%, while bezafibrate had the broadest effect on cholesterol.[Comparison of the efficacy of pantethine, acipimox, and bezafibrate on plasma lipids and index of cardiovascular risk i…
- In 72 children and adults with high cholesterol, taking pantethine at 900 to 1200 mg daily for 3 to 6 months lowered total cholesterol, bad cholesterol, triglycerides and apolipoprotein B, and raised good cholesterol and apolipoprotein A-I.Lipoprotein changes induced by pantethine in hyperlipoproteinemic patients: adults and children.
- In 37 people with high cholesterol or triglycerides, 600 mg of pantethine daily for 3 months steadily lowered cholesterol and triglycerides and raised good cholesterol, with values returning toward baseline after stopping.[Hyperlipidemia, diabetes and atherosclerosis: efficacy of treatment with pantethine].
- In 31 patients on chronic hemodialysis with blood fat problems, pantethine at an average of 970 mg daily for about 9 months reduced total cholesterol in those with high cholesterol and significantly lowered triglycerides, with no side effects reported.Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial.
- In 31 people with diabetes and high cholesterol, pantethine lowered total cholesterol from about 236 to 217 mg/dl and raised HDL cholesterol, and also normalized platelet fats and reduced platelet clumping.Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hy…
- In 24 women aged about 45 to 55 with high cholesterol, 900 mg of pantethine daily for 16 weeks significantly lowered total and bad cholesterol, with no reported side effects.[Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age].
- In 24 people with high blood fats not controlled by diet alone, one year of pantethine treatment consistently lowered total, bad and fatty cholesterol, while raising good cholesterol, with no side effects reported.Effectiveness of long-term treatment with pantethine in patients with dyslipidemia.
- In 22 diabetic people on dialysis with high cholesterol and triglycerides, 900 mg of pantethine daily lowered cholesterol, VLDL and triglycerides over 6 months with few side effects.Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance.
- In 18 people with high blood fats, 400 mg per day of pantethine given as injections for 20 days lowered cholesterol and triglycerides and raised HDL cholesterol, with excellent tolerability.[Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia].
- In 16 Japanese patients with fatty liver inflammation and high cholesterol, 600 mg daily of pantethine with 500 mg of probucol for 48 weeks significantly lowered total cholesterol along with liver enzymes, with no side effects reported.Combined pantethine and probucol therapy for Japanese patients with non-alcoholic steatohepatitis.
- In 16 people with diabetes and raised clotting marker levels, pantethine (600 mg for 3 months, then 1200 mg for 6 months) significantly lowered the clotting marker, triglycerides, total cholesterol and other blood fats over 9 months.Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus.
- In 12 male stroke survivors, 1000 mg of pantethine daily for 3 months tended to lower total cholesterol and LDL cholesterol and significantly raised HDL cholesterol and apolipoprotein A-I.The effects of pantethine on lipid and lipoprotein abnormalities in survivors of cerebral infarction.
- In 4 children with cystinosis given pantethine by mouth at 70 to 1,000 mg per kg daily, serum cholesterol fell by an average of 14%, but the drug was broken down quickly and was less effective than cysteamine for the cystinosis itself.Metabolism of pantethine in cystinosis.
- In a large post-marketing surveillance of 1045 people with high cholesterol, about 900 mg of pantethine per day improved lipid levels similarly in those with and without diabetes, with very good tolerability.[Pantethine, diabetes mellitus and atherosclerosis. Clinical study of 1045 patients].
- In 20 people with abnormal blood fats in a single-blind crossover study, pantethine lowered total cholesterol and triglycerides and raised HDL (good) cholesterol.Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment.
- Mouse and lab work plus a small investigator-run trial in psoriasis patients suggest pantethine calms overactive immune cells and eases psoriasis symptoms; cholesterol lowering was not measured as an outcome.Vanin-pantethine metabolic axis shapes dendritic cell function and affects inflammatory disorder progression.
Review Totals and Summary
Members Only1,892 reviews · 93% positive
Customers on iHerb and similar retailers mostly describe Thorne Pantethine as a trusted, high-quality product, and brand trust comes up more than any other theme. Many reviewers say they buy it because they already rely on Thorne's quality and consistency across its supplements. Several note that it is one of the few pantethine products sold in capsule form, and some are repeat buyers who have reordered several times. The reasons people take it fall into two groups. The first is cholesterol and lipid management. Some reviewers say they cannot tolerate niacin, or that it stressed their liver, so they tried pantethine as an alternative. They then encourage others with high cholesterol to try it. The second group is energy and adrenal support. Many reviewers were guided by a naturopath, often as part of an adrenal-fatigue recovery plan or a combination of adrenal-support supplements. They say it gave them a noticeable energy boost, and some report better mood and general well-being. One person who took a small dose for a year described the energy benefit as effective. Another reviewer took it for skin because they had heard pantothenic acid is good for it. Tolerability is mostly positive. One reviewer says it was the only pantethine they had taken without stomach problems, and another reports no side effects. People value that, since many B-vitamin products upset the stomach. Another reviewer on iHerb said they turned out to be sensitive to pantethine as well as to niacin. So a small minority did not tolerate it. Reviewers often describe the benefit as supportive rather than dramatic. Some mention taking it in courses, for example once every six months, and some say it helps because they believe their body does not make enough pantethine. Many reviews are brief, mostly saying the quality is excellent, and some were posted as rewarded reviews, which may make them more positive. Complaints are few. Reviews on the pages I could access were not detailed on pill size, taste or price. The main negatives are individual sensitivity and the fact that it takes consistent use before effects show. The iHerb listing I found was marked as discontinued, so availability may be an issue there. Other retailers still carry it, at about $0.67 per serving per SuppCo. This summary draws on the review pages I could read, mainly iHerb. Customers outside the iHerb pool, such as those on Amazon, were not covered in depth.
Biohacker Summary
Members Only10 of 10 recommend it
Only two of the ten panelists spoke about pantethine, the main ingredient, so this is a small sample. One of them recommends it, describing it as a form of vitamin B5 that can help lower a blood marker, and the other uses it for cholesterol. The one dose given was 600 mg taken twice a day. Neither panelist mentioned preferred forms, pairings, cautions, or anyone who stopped taking it.
See all 2 biohackers →Hide the biohackers
Ben Greenfield · Pantethine · recommends
- Suggests pantethine, a derivative of vitamin B5, as something that can help lower Apple B.
Peter Attia · Pantethine · uses
- Takes 600 mg of Pantethine twice a day for cholesterol.
RAL Summary
Members OnlyTier 2 for Cholesterol
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Metabolic system
Combine with: For cholesterol and cardiovascular support, pantethine pairs well with omega-3 fish oil (EPA/DHA) for triglycerides, plant sterols or soluble fiber such as psyllium for LDL, and CoQ10 (ubiquinol), especially for people on meds. Bempedoic-style or red yeast rice products should be used only with clinician guidance. Niacin or berberine can add lipid or glucose benefits but should be medically supervised. If the goal is anti-aging and DNA repair, a better-matched stack would include NMN or NAD+ precursors such as nicotinamide riboside, resveratrol or pterostilbene, quercetin and fisetin, and magnesium. Pantethine can sit alongside these as a metabolic and lipid support, not as the primary anti-aging agent.
Possible side effects: The studies reported very good tolerability. No written reviews could be read, so nothing is known about side effects reviewers mention.
Supplement Facts
Pantethine 250 mg
| Pantethine | 250 mg | † |
Other ingredients: Hypromellose, Calcium Laurate, Leucine, Silicon Dioxide, Magnesium Citrate.
Directions: Suggested use: Take 1 capsule two to three times daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749706038 · Label source: NIH label database · Report a label change
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- Best Diet for High Cholesterol: What to Eat, What to Cut, and What the Trials ShowArticle · Sep 13, 2026
- How to Lower LDL Cholesterol: A Practical Plan Based on Your Blood WorkArticle · Oct 27, 2026
Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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