Thorne Pyridoxal 5'-Phosphate Review
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Study, Trial or Testing Result Summary
Members Only2 human studies · 2 improved
This product gives vitamin B6 in its active form at about 101 milligrams a day, which is above the daily recommended limit; members can take less. The evidence for men's hormones is limited. A 2022 review of 31 trials with 1999 people found that adding high-dose vitamin B6 lowered prolactin, a hormone that can reduce sex drive and fertility, in people whose antipsychotic medicines had raised it above 50 nanograms per milliliter. No treatment beat placebo when levels were below that mark [1]. A 2020 controlled trial in 100 men with fertility problems gave half of them a daily antioxidant blend that included vitamin B6 for 6 months. Their testosterone and the two brain hormones that drive testosterone and sperm production rose from where they started, while the untreated group showed no change. Sperm count did not improve significantly [2]. Because vitamin B6 was only one part of that blend, the trial cannot show what vitamin B6 alone did. Neither study reported the vitamin B6 dose, and neither looked at healthy men. Animal and cell studies are never counted.
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- Across 31 trials with 1999 people with antipsychotic-induced high prolactin, adding high-dose vitamin B6 lowered prolactin significantly in those with levels above 50 ng/ml, but no treatment beat placebo when levels were below 50 ng/ml.Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-…
- In 100 infertile men, half took a once-daily multi-ingredient antioxidant supplement (including vitamin B6) for 6 months; their FSH, LH and total testosterone rose significantly from baseline while the untreated control group showed no change, and sperm count did not significantly improve.Do antioxidants improve serum sex hormones and total motile sperm count in idiopathic infertile men?
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
The panel is split on vitamin B6, the main ingredient here, with four of the seven who gave a recent view leaning toward recommending or using it and three warning or staying neutral. Those in favor take it for nervous system health, estrogen and histamine handling, sleep and melatonin production, calming support alongside magnesium, and for people with low levels or a gene variation that affects B6. Two panelists prefer the active form, pyridoxal 5 phosphate, over the synthetic pyridoxine form, which one of them lists as something to avoid and another warns about. The one dose given in the statements was 50 to 100 for estrogen support, while another panelist takes a very large daily amount for longevity. Caution runs through the group: two warn that high intake is linked to nerve damage, and one avoids supplementing B6 for that reason.
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Dr. Eric Berg · Vitamin B6 · warns
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- States that high vitamin B6 levels can be linked to peripheral neuropathy.
- Mentions vitamin B6 as a required cofactor for Vitamin D to be properly absorbed and used by the body.
- States that Vitamin D needs K2, magnesium, zinc, B6, boron, and even vitamin A to do its job, emphasizing that vitamins rarely work alone.
- Recommends P5P as the active form of vitamin B6, advising against pyridoxine HCl which is inactive and may not convert properly due to genetic issues.
- Warns that unconverted vitamin B6 can accumulate in the body and affect the nervous system, worsening nerve pain, especially if the liver is sluggish, bile is insufficient, or glutathione is low. He advises not to exceed 50 mg per day.
- Mentions that if one doesn’t have enough vitamin B6, it may seem that magnesium is not working.
- Mentions that vitamin B6 is necessary for magnesium to get into cells.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
- Recommends Vitamin B6 to support histamine metabolism and gave it to a patient two times a day to help her body break down histamine.
- Dr. Hyman recommends vitamin B6 for easing PMS symptoms, stating it is important for estrogen metabolism.
- Advises moving away from some over-the-counter gummy vitamins due to their high sugar content, which can lead to kids consuming a mouthful of sugar.
- Dr. Hyman highlights the importance of B12, B6, and folate, noting that high homocysteine levels, which indicate inadequate function of these B vitamins, are associated with high blood pressure and diabetes in pregnancy.
- Notes that deficiencies in nutrients like vitamin B6 can cause low magnesium.
- Recommends B6 as a methylating vitamin needed for detoxification.
Thomas DeLauer · Vitamin B6 · recommends
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
- Mentions B12 as a critical B vitamin for reducing homocysteine.
- Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
- Says his kids love taking Hiya multivitamins because they are sweetened with monk fruit and have no sugar, making it a fun ritual for them.
- Thomas DeLauer, a dad of two young kids, recommends Hiaa Kids Multivitamins as a fun and beneficial chewable multivitamin, sweetened with monk fruit, that helps establish a good routine for kids.
- Warns against taking synthetic Vitamin B6 (pyridoxine or pyridoxine HCL) because it can cause peripheral neuropathy and clogs B6 receptors for a long time.
- Says that while he's not the biggest fan of giving kids a bunch of supplements, he understands his kids don't always eat everything he wants them to, and Hyatt multivitamins help them get additional vitamins. He also says his kids love them and he probably eats more of them than his kids do.
- Discusses that Vitamin B6 is beneficial for eyesight and can reduce the risk of advanced macular degeneration, likely by helping to break down homocysteine which can damage eye vessels.
- Notes that the multivitamin he takes uses methylcobalamin for B12, which he considers superior to cyanocobalamin, a cheap shortcut.
Dave Asprey · Vitamin B6 · neutral
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
- Says they would take a bunch of their Wild Lights Vitamin B6 if they had to eat almonds, to try and pass them.
- Warns about formulating with Vitamin B6.
- Identifies P5P, a bioactive form of vitamin B6, as a great cofactor for melatonin production, helping the body naturally produce the hormone.
- Recommends feeding the tryptophan pathway with vitamin B6, as it is depleted by birth control and its depletion can lead to depression.
- Mentions P5P in the context of epigenetic alterations, comparing it to vitamin B6.
- Recommends supplementing with Vitamin B6 if homocysteine levels are high, indicating a methylation issue or B12/folate deficiency.
Ben Greenfield · Vitamin B6 · recommends
- Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
- Lists vitamin B6 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
- Leland ensures adequate Vitamin B6 for patients to optimize endogenous melatonin production.
- Ben recommends HIYA Kids Multivitamin as a pediatrician-approved, superpowered chewable multi that is zero sugar, non-GMO, vegan, dairy-free, allergy-free, gelatin-free, and nut-free, formulated with 12 organic fruits and veggies and 15 essential vitamins and minerals.
- Warns that most typical children's vitamins are basically candy in disguise, containing two teaspoons of sugar, unhealthy chemicals, and gummy junk that growing kids should never eat.
- Ben mentions that tryptophan and vitamin B6 are necessary to produce melatonin.
- States that up to 85% of the vitamin B6 made in the body can be produced by species in the gut, highlighting the gut's role as a 'small pharmacy' for vitamin production.
- States that they use some vitamin B6.
- Explains that Vitamin B6 (P5P) helps with about 30 of magnesium's enzymatic reactions, including serotonin and dopamine manufacturing, and is involved in the absorption of magnesium.
- Ben recommends Thorne Vitamin B Complex for healing nerve damage.
Siim Land · Vitamin B6 · neutral
- Mentions that insufficient vitamin B6 can raise prolactin levels.
- Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
- Is experimenting with serine plus vitamin B6 to impact homocysteine levels, a mechanistic hypothesis he is testing.
- Takes 1 gram of Vitamin B6 from DoNotAge in the morning for longevity.
- Mentions vitamin B6 as another example where the principle of metabolic conversions from plant to animal forms applies, with genetic variations affecting the ability to get B6 from plant foods.
Andrew Huberman · Vitamin B6 · warns
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
- Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
- Described how some people take vitamin B6 to reduce prolactin levels and thereby reduce the duration of the refractory period, but he is not suggesting anyone do this.
- Mentions Vitamin B6 as a mild prolactin inhibitor.
- Huberman states that he used to take a couple hundred milligrams of vitamin B6 after major events to offset the post-achievement low, noting it seemed to have a positive effect, but advises caution for those with diabetic neuropathy.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, but there are no human data yet.
- He mentions that B6 and NMN are where the Krebs cycle starts to kick in, and all B vitamins basically run that entire circle.
Dr. Rhonda Patrick · Vitamin B6 · recommends
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- Dr. Rhonda Patrick explores high-dose vitamin B6.
- Notes that very high doses of vitamin B6 can overcome a specific mutation in the ornithine aminotransferase enzyme, preventing progressive blindness.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Men
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system
Possible side effects: No major side effects reported. The daily amount is above the recommended limit, so members may choose to take less.
Supplement Facts
Vitamin B6 33.8 mg
| Vitamin B6 | 33.8 mg |
Other ingredients: Microcrystalline Cellulose, Hypromellose, Calcium Laurate, Silicon Dioxide.
Directions: Suggested use: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749126034 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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