Thorne Research Radiant Skin Complex Review
Radiant Skin Complex is a Thorne Research skin support supplement presented as a way to enhance natural aesthetic with cellular support for skin hydration and collagen integrity. The product is described as promoting smoother, softer skin with antioxidant-rich botanicals, hyaluronic acid, and eggshell nutrients that help fortify the skin barrier and reduce the appearance of fine lines and wrinkles. The page states that the product carries NSF Certified for Sport. The listed key ingredients are OVOLUX Eggshell Membrane, the eternalyoung Botanical Blend, and Hyaluronic Acid. Each serving is two capsules, and the container holds 30 servings, which the page describes as a simple once-daily, two-capsule serving. The ingredient amounts listed are 400mg of OVOLUX Eggshell Membrane, 225mg of eternalyoung Botanical Blend, and 120mg of Hyaluronic Acid. Other ingredients include a hypromellose capsule, microcrystalline cellulose, and ascorbyl palmitate. The page explains that Ovolux is a patented, sustainably sourced ingredient that extracts nutrients from eggshell membrane and that it uses unhydrolyzed eggshell, which the brand says shows enhanced bioactivity compared with hydrolyzed forms. The eternalyoung blend is described as a mix of pomegranate, sweet orange, Cistanche, and gotu kola, which the page links to antioxidant support, protection against free-radical damage, a healthy inflammatory response in the skin, and visible reduction of fine lines within about four weeks. Ovolux is described as supporting skin elasticity and firmness in as little as six weeks and as enhancing overall skin appearance after twelve weeks. The page lists benefits including reducing fine lines and wrinkles, promoting hydration, supporting elasticity and firmness, supporting even texture and tone, and helping to maintain collagen integrity. It is aimed at adults seeking alternatives or complements to topical skincare, people with early signs of skin aging, women and men who want to maintain healthy skin, perimenopausal and postmenopausal women, and people with loose skin after weight loss. The page advises pairing the product with collagen supplements such as Thorne Collagen Plus. The warnings state that the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, that it contains an ingredient derived from egg, and that anyone who is pregnant, nursing, or trying to conceive should not use it. The page reports no known adverse interactions at publication date.
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Study, Trial or Testing Result Summary
Members Only36 human studies · 32 improved
12 of these 36 human studies gave the ingredient by injection, not by mouth.
Eggshell membrane, at 400 milligrams here, has the best support. In a trial of 88 middle-aged adults, 450 milligrams a day for 12 weeks improved the look of crow's feet wrinkles by week 4 and skin tone by week 8 compared with a dummy pill [1]. Another trial found 300 milligrams a day for 57 days improved skin firmness, flexibility and elasticity more than a dummy pill or a large dose of collagen [2]. The eternalyoung blend of rosemary and grapefruit extracts, at 225 milligrams here, reduced sun-caused skin redness at 100 or 200 milligrams in one small trial of 20 adults, but wrinkles and moisture were not measured [3]. For hyaluronic acid taken by mouth, a pooled analysis of 7 trials found better skin hydration, elasticity and wrinkle depth [4]. However, one trial in 87 women found adding it to collagen gave no extra benefit [5]. Whether the 120 milligrams here matches the studied doses is unclear. Most other hyaluronic acid studies tested injected fillers or creams, which do not apply to capsules [6]. The calcium studies tested calcium injected into the skin as a filler, so they say nothing about the small 52 milligram amount in this capsule [7]. Animal and cell studies are never counted.
See all 36 studies →Hide the studies
- Pooling 6 studies, hyaluronic acid injections improved skin hydration and radiance but did not significantly change skin elasticity or melanin index compared with controls.The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis.
- Combining 7 placebo-controlled trials, oral hyaluronic acid significantly improved skin hydration, elasticity and wrinkle depth, while firmness, wrinkle volume and water loss showed only non-significant trends.Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
- In 24 studies of 1,410 patients, mostly women, hyaluronic acid fillers persisted 60-86.4% at 12 months and 50-86% at 24 months, with rare long-term side effects.Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review.
- A review found injected calcium hydroxylapatite filler to be safe and effective for cheeks, jawline and nasolabial folds, though no randomized trials existed for diluted forms.A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for tre…
- A review found diluted injected calcium hydroxylapatite gave a skin-tightening effect on body areas with a good safety profile, but randomized trials were lacking.A systematic review of Radiesse® (calcium hydroxylapatite): evidence and recommendations for the body.
- A review of 45 articles on injectable skin biostimulators, including calcium hydroxylapatite, found they may mitigate facial aging, but quantifiable data are limited and more controlled studies are needed.The emerging role of biostimulators as an adjunct in facial rejuvenation: A systematic review.
- A review of 29 small, varied studies found injected calcium hydroxylapatite combined with ultrasound, laser or microneedling improved skin texture and elasticity, though side effects occurred in 15-30% of cases.A Systematic Review on the Effectiveness and Safety of Combining Biostimulators with Botulinum Toxin, Dermal Fillers, an…
- A review found combined hyaluronic acid and calcium hydroxylapatite treatments gave high aesthetic effectiveness and satisfaction for facial rejuvenation, with a slight decline after six months.Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechan…
- A review of 14 studies found injected calcium hydroxyapatite (and poly-L-lactic acid) improved facial skin elasticity and reduced wrinkles, with results lasting 12 to 18 months for calcium hydroxyapatite.Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatit…
- A review of 37 articles on lip rejuvenation found hyaluronic acid was the most used agent with few side effects, and one report showed 94.3% improvement in lip fullness one month after re-treatment.Perspectives and challenges in lip rejuvenation: a systematic review.
- In 117 people with moderate to deep nasolabial folds, 79% had better improvement on the side injected with calcium hydroxylapatite than the side with human collagen over 6 months.A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for …
- In 88 healthy middle-aged adults, 450 mg a day of hydrolyzed eggshell membrane for 12 weeks improved the look of crow's feet (by 4 weeks), skin tone (by 8 weeks) and hair compared with placebo, but did not improve nails.The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle-aged adults…
- In 87 women aged 40-65 taking 30 mg hyaluronic acid with collagen and vitamin C for 16 weeks, skin density, texture and wrinkles improved but elasticity and hydration did not, and adding hyaluronic acid gave no extra benefit over collagen alone.The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin De…
- In 24 women aged 35-45, calcium hydroxylapatite filler injected on one side produced more collagen and elastin than a hyaluronic acid filler on the other side over 9 months, with less inflammation.A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-ba…
- In 22 people, calcium hydroxyapatite injected into the hands improved skin hydration, thickness and appearance over 90 days, with no difference between dilution types.Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind Clini…
- In 21 people given facial injections near the nasolabial fold for 13 weeks, calcium hydroxylapatite showed no evidence of tissue regeneration and turned on more inflammation-related genes than poly-L-lactic acid.Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflamma…
- In 20 light-skinned adults in a placebo-controlled crossover trial, a rosemary and grapefruit extract blend at 100 or 200 mg significantly reduced sun-induced skin redness from the first day and sped recovery, and in lab skin-cell tests it protected collagen and elastin.Skin Photoprotection and Anti-Aging Benefits of a Combination of Rosemary and Grapefruit Extracts: Evidence from In Vitr…
- In women with decollete wrinkles treated with diluted calcium hydroxylapatite injections over up to 52 weeks, 73.5% improved by at least one grade on a wrinkle scale 16 weeks after the last treatment, with a favorable safety profile.A Prospective, Multicenter, Evaluator-Blinded, Randomized Study of Diluted Calcium Hydroxylapatite to Treat Decollete Wr…
- In people with signs of skin aging, 300 mg a day of fresh eggshell membrane for 57 days improved skin firmness, flexibility and elasticity more than 8,000 mg of hydrolyzed collagen or placebo.Comparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties…
- In 76 women with moderate sun-aged skin, injections of hyaluronic acid combined with platelet-rich plasma worked significantly better than hyaluronic acid injections alone on skin hydration, firmness and satisfaction scores.Comparative analysis of effects induced by hyaluronic acid and its combined formula on skin functional parameters in sec…
- In 80 people who had repeat Juvéderm filler in nasolabial folds, wrinkle scores stayed mild at 48 weeks, 78-90% responded, and 60% less filler was needed than at first treatment.Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers.
- In 1462 people applying a retinaldehyde and hyaluronic acid fragment cream daily for 90 days, overall photoaging, wrinkles (up to 34% less) and skin elasticity signs (about 32% better) improved significantly.Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging.
- In 44 women using a niacinamide and hyaluronic acid formula for two months, fine lines, wrinkles and smoothness improved, and in 30 other women skin biopsies showed lower activity of aging-related inflammatory genes.Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin …
- In 40 women using an antioxidant serum containing hyaluronic acid daily for 90 days, signs of skin aging improved significantly and the serum was well tolerated.Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in re…
- In 34 people treated on the face, neck, chest and hands with hyaluronic acid jetted into the skin (not a supplement taken by mouth), wrinkle scores on the face and neck fell by about 39% and 30% at 1-3 months, and 80% were satisfied.Clinical results of skin remodeling using a novel pneumatic technology.
- In 30 Chinese women using hyaluronic acid microneedle patches under the eyes three times a week for 4 weeks, skin firmness increased and crow's feet and eye bags significantly reduced.Efficacy and safety testing of dissolving microarray patches in Chinese subjects.
- In 30 Chinese women given two hyaluronic acid injection sessions four weeks apart, skin hydration and water loss improved significantly by week 12, while elasticity changes were not significant.Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in As…
- In 20 women with sun-aged hands, weekly hyaluronic acid microinjections for 4 weeks increased a skin ultrasound marker of photoaging by 31.3%, improving it in 15 of 19 who finished.Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross…
- In a retrospective study of 129 patients, a hybrid filler containing calcium hydroxylapatite improved facial appearance, firmness, and elasticity at 9 months, with only minor side effects.HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.
- In 42 patients with 74 frown-line wrinkles, ultrasound showed an artery at the wrinkle in 30 lines (filler skipped there) and lateral in 44, where filler was injected safely to correct the wrinkles.Safe Glabellar Wrinkle Correction With Soft Tissue Filler Using Doppler Ultrasound.
- In 40 patients, injected calcium hydroxylapatite, alone or after a topical exosome treatment, improved skin tone, quality, and texture over 30 days, and the combination worked faster.Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation.
- In 32 adults aged 35 to 59, diluted calcium hydroxylapatite injections gave visible improvement in 85% of patients at 120 days, with 75% still reporting benefit at 360 days, and dermal thickness rose 51% on ultrasound in a subset.Clinical Evaluation of an Innovative CaHA Bio-Stimulator in Facial Rejuvenation: 1 Year Follow-Up.
- In a pilot study of 3 people, calcium hydroxylapatite particles persisted for 6 months with new collagen formation, and patients still showed clinical improvement at that time.Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler.
- In a case series, priming the skin with a micronutrient diluent before calcium hydroxylapatite improved wrinkles, laxity, and skin thickness in all patients after a single treatment.Optimizing Skin Regenerative Response to Calcium Hydroxylapatite Microspheres Via Poly-Micronutrient Priming.
- This review describes an injectable calcium-based filler, Radiesse, approved in 2006 to correct moderate to severe facial wrinkles, with the correction lasting about one year; it reports no numbers of people, trial results, or comparison with a control group.Injectable calcium hydroxylapatite microspheres (Radiesse).
- In lab and hairless mouse studies, solubilized eggshell membrane increased type III collagen in the skin, and in a small human application it improved arm elasticity and reduced facial wrinkles.Solubilized eggshell membrane supplies a type III collagen-rich elastic dermal papilla.
Review Totals and Summary
Members Only85 reviews · 81% positive
**Overall:** Across the stores the product carries about 35 ratings. The written feedback is mostly positive and centers on skin appearance, though the ratings are more mixed than the comments, and the reasons for the lower ones aren't visible. **What buyers say it did for them:** Most say they saw a change in their skin, often described as a glow. Timing ranges from one week to three months. One buyer writes, "I noticed the results after a week and my skin is glowing!" Another says the difference is "Not just on my face, but all over." A third says, "I notice a difference in my skin texture and appearance." One also mentions a difference in hair, and another credits it with helping their joints and general health. **Mixed or lukewarm experiences:** Some buyers are more tentative. One has taken it for a month and says, "I don't notice anything drastic but my skin feels nice." A second-bottle buyer says, "I'm not sure if it's helping," and plans to keep taking it anyway. The store page shows lower star ratings (three at 3 stars or below) but no text explaining them, so the reasons for those are unknown. No written review complains of side effects, aftertaste, capsule size or price. **Taste, smell, pill size, form:** Taste gets one positive mention: "Love the taste and the way it helps my health." Another reviewer says the company's products are always good in "quality, dosage and size," a general remark about the brand rather than this product alone. Nobody reports problems with swallowing the capsules. Reviews of other forms of the product were left out, and this summary covers the capsules only. **Value for money:** Nobody comments on price, so there is nothing in the feedback to say whether it is good value. Repeat purchase is the only hint: one buyer is on a second bottle, and another says they will use it regularly. **Who it seems to suit and who it did not:** It seems to suit people who already trust Thorne and are looking for a skin-focused supplement, and who are willing to take it for a few weeks to a few months. One reviewer calls Thorne "one of my favorite company of vitamins." Those hoping for dramatic results may be disappointed, since some buyers describe only subtle effects or are unsure of any effect. The feedback doesn't identify any group for whom it clearly failed, and the unexplained lower star ratings leave that question open. **Bottom line:** Buyers who report results mostly describe a nicer, glowier look to the skin, sometimes within a week and sometimes taking longer. A few are unsure it does anything. The written feedback raises no concerns about taste, size or side effects, but it also doesn't speak to price.
Biohacker Summary
Members Only9 of 10 recommend it
Only one panelist spoke about eggshell membrane, the main ingredient, and he recommends it, noting that a collagen product contains it and that it has been shown to support joint function. No one else on the panel addressed it, so there is little to go on for forms, doses or pairings. Calcium, a smaller ingredient in this product, drew the most comment: several recommend it for bone health, one suggests 1,000 to 1,200 milligrams a day from food and supplements, and others prefer getting it from foods like sardines and leafy greens. Two of them warn against supplemental calcium, one citing kidney stones and one citing hardening of the arteries, and one keeps multivitamins low in calcium. Hyaluronic acid, also a smaller ingredient in this product, is mostly recommended for skin hydration, with one panelist taking 300 milligrams a day for joints.
See all 10 biohackers →Hide the biohackers
Siim Land · Eggshell Membrane · recommends
- Highlights that Nordic Kodo collagen has eggshell membrane, which has been shown to support joint function.
- Lists dairy and sardines as sources of Calcium.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- Notes that the addition of 30 mg of hyaluronic acid provided some small additional benefits for skin health when combined with vitamin C and hydrolyzed collagen.
- Notes that there are a few clinical trials on hyaluronic acid reducing skin wrinkles and dryness, but a smaller amount of studies compared to collagen.
- States that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- States that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
- States that topical hyaluronic acid lacks evidence for skin benefits because it doesn't get absorbed well, although some newer products have modified molecular structures to improve absorption.
- Includes hyaluronic acid in his 'all out' supplement stack.
- Recommends hyaluronic acid for skin anti-aging, noting it helps with skin hydration.
- Mentions that eating enough calcium matters for bone density, but states that it alone won't transform bone density.
Dr. Mark Hyman · Hyaluronic Acid · recommends
- Likes working with Pique for healthy skin, specifically their Radiant Skin Duo, which combines BT Fountain (electrolytes, ceramides, hyaluronic acid) and Sun Goddess Matcha (antioxidants, L-theanine) to support hydration and skin barrier from the inside.
- Mentions hyaluronic acid as a nice hydrating ingredient.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
- Lists calcium as another important nutrient that people can be tested for and measured.
- States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
- Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
- Recommends calcium citrate, about 600 milligrams a day, for bone health, noting that much can also be obtained from diet through leafy greens, sesame seeds, tahini, and chia seeds.
- Dr. Hyman notes that while calcium deficiency is not common in terms of blood levels, insufficient intake can lead to osteoporosis as the body pulls calcium from bones. He advises caution with calcium supplementation due to potential heart issues.
- Dr. Hyman mentions hyaluronic acid as a lubricant used in traditional orthopedic treatments for osteoarthritis.
Dr. Eric Berg · Calcium · warns
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
- Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including calcium.
- States that calcium and magnesium are intrinsically linked and work in combination with vitamin D to support the body's calcium balance.
- Explains that calcium triggers muscle contraction, while magnesium is needed to relax the muscles afterward.
- Warns that too much calcium can cause high blood pressure by causing arterial contraction.
- Notes that hyaluronic acid, while a natural remedy for skin hydration, only works on a superficial layer and does not address the root cause of facial aging, which involves muscles and bones.
- Dr. Berg recommends prioritizing foods rich in hyaluronic acid or those that support its production, such as bone broth, organ meats, chicken skin, nuts, seeds, or snow mushrooms, to add moisture and boost skin hydration.
Bryan Johnson · Hyaluronic Acid · recommends
- Considers hyaluronic acid essential for their routine, stating it retains moisture, giving the skin extra firmness and texture, and helps counteract the decrease in levels that occurs with age, leading to dehydrated skin.
- Uses hyaluronic acid as part of his nighttime skincare routine.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Takes 300 milligrams of hyaluronic acid a day for joint health.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends continuing with calcium to support bone health during the follicular phase.
Thomas DeLauer · Calcium · neutral
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
- Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
- Recommends providing the body with adequate dietary calcium, not a calcium supplement, to ensure a clean, strong spark for efficient insulin release.
- Warns that calcium and magnesium should not be taken together as they cancel each other out, though some products use delayed absorption to mitigate this.
- Warns that most people consume too much calcium relative to magnesium, which can disrupt the balance needed for proper bodily function, comparing it to an electrical circuit.
- Recommends supplementing with hyaluronic acid, noting its role in collagen formation by providing an elastic component and drawing water for supple, smooth, and flexible skin and hair.
- Explains that hyaluronic acid draws moisture into the collagen matrix, making it flexible and functional, and recommends it for supporting collagen production.
Dave Asprey · Hyaluronic Acid · recommends
- Explains that hyaluronic acid is gradually laid down through access points in the shaft for girth enhancement, using six syringes of filler per treatment. He notes that the body slowly absorbs it, and men usually need a top-off every 18 months to maintain their goal girth.
- States that he hardly ever uses a moisturizer and doesn't believe topical hyaluronic acid is necessary to make skin look good if it's not dry.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Recommends taking calcium citrate during a high oxalate meal to bind the oxalate in the gut.
- Notes that people often take calcium for bone health.
- Believes calcium supplements are overrated, as most people need more vitamin K2 and vitamin D instead.
- Advises looking into rehydrating skin with hyaluronic acid eventually.
- Advises taking iron and calcium separately because they will bind together.
- Uses hyaluronic acid in his osteoarthritis patients, especially before regenerative procedures, to get cells into a better state by blocking inflammation.
- Takes extra calcium to help deal with the burden when eating chocolate or anything with higher levels of oxalates.
- Discusses calcium citrate as a counter to oxalate crystals, specifically when consumed through dairy, but questions if it's the primary form of calcium in dairy.
Dr. Rhonda Patrick · Calcium · neutral
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
- Takes a calcium-magnesium pill because he believes people tend to be short of both and that the body cares about the ratio of these similar molecules.
- States that 1,000 milligrams of calcium per day is the recommended intake for bone density, and supplementation is an option if this requirement is not met.
- Takes a calcium, vitamin K2, and vitamin D combination supplement in the morning, providing about 600 mg of calcium and another 1,000 IUs of vitamin D.
- Dr. Rhonda Patrick discusses calcium needs.
- Dr. Rhonda Patrick explores oral hyaluronic acid.
Ben Greenfield · Hyaluronic Acid · uses
- Combined hyaluronic acid with exosomes and did a full facial.
- Recommends a hyaluronic acid serum after applying hypochlorous acid because hypochlorous acid can be drying, and hyaluronic acid is a hydrating molecule that works well with it.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Mentions that hyaluronic acid is involved in the Wing Lift protocol.
- Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
- Warns that in high doses, calcium without the right cofactors can raise cardiovascular risk by contributing to arterial calcification instead of bone strength, and may increase the risk of osteoporosis.
- Explains that 10X separates calcium and zinc into different micro beads, releasing them at different rates and locations in the digestive tract to prevent competition and optimize absorption.
- Recommends using hyaluronic acid after sun exposure to maintain overall skin health.
- Covers calcium as a key supplement for kids.
- Ben's guest, Dr. Cameron Chestnut, warns that hyaluronic acid fillers are often misused and misunderstood, as they last for decades rather than months, leading to problematic gel collection and migration.
- Warns of calcium deficiency on a carnivore diet, as there is not an appreciable amount in meat, and recommends eating fish with bones or taking a calcium supplement or bone mineral matrix.
Peter Attia · Calcium · recommends
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that hyaluronic acid injections are doing better than cortisone for joint pain, and that combining hyaluronic acid with PRP seems more effective than other treatments, though not astronomically so.
- Mentions that hyaluronic acid injections are another treatment option that performs better than cortisone over a year.
- Says he would give hyaluronic acid in the hip, even though it's not FDA approved for that application, as it can be used off-label and some studies suggest it can help.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
- Suggests that calcium is one of the other signals involved in regulating mitochondrial number, beyond AMPK activation.
- States that in postmenopausal women not on estrogen, calcium and vitamin D have no protective effect against hip fracture because the problem is not the shell of the bone, which is fed by calcium and vitamin D, but the internal girder network.
- Peter Atia discusses hyaluronic acid fillers, noting they are a constituent of skin, very safe, biocompatible, and reversible with an enzyme.
- Notes that compelling evidence links calcium to reduced risk of osteoporosis, which can impact mortality from specific causes.
Andrew Huberman · Hyaluronic Acid · neutral
- Reviews data on ingesting or topically applying hyaluronic acid to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
- Explains that hyaluronic acid is a natural component of the skin that holds water, providing a plump and moist look characteristic of youthful skin, and mentions dermatologists suggest supplementation or topical application.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Adequate intake of calcium is vital for bone health.
RAL Summary
Members OnlyTier 3 for Younger-Looking Skin for Women
Tier 3 fits: 95 reviews with 81% positive, and human studies give some support, mainly from eggshell membrane at a full dose and a pooled analysis of oral hyaluronic acid trials. The 15 of 17 hyaluronic acid count is inflated by injection and cream studies, but the tier still holds.
Where the evidence disagrees: 2 of the 36 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skin
Combine with: Thorne Radiant Skin Complex is a skin-focused formula (typically combining ingredients such as collagen peptides, hyaluronic acid, vitamin C, antioxidants like astaxanthin or lutein, and skin-supporting nutrients), so it aligns well with goals for wrinkles, elasticity and hydration. Note that the ingredient list was not itemized, so exact doses are assumed from the product's positioning. To enhance results, consider stacking with additional vitamin C (500 to 1,000 mg daily) to support collagen synthesis, and omega-3 fatty acids (EPA/DHA, 1 to 2 g daily) to support the skin barrier and reduce inflammation. Ceramides or phytoceramides (30 to 350 mg) can improve moisture retention, while a broad-spectrum antioxidant such as astaxanthin (4 to 12 mg) or a vitamin E complex may help protect against UV-related oxidative damage. Zinc and biotin can support skin renewal and hair and nails. Pair with daily sunscreen, a topical retinoid, adequate water intake, and sleep, since these have the strongest evidence for visible anti-aging. Check with a clinician if pregnant, on meds, or taking medications before adding new supplements.
Possible side effects: No major side effects reported.
Supplement Facts
Calcium 52 mg · OVOLUX™† Eggshell Membrane 400 mg · eternalyoung®†† Botanical Blend 225 mg
| Calcium | 52 mg | |
| Sodium | 10 mg | |
| OVOLUX™† Eggshell Membrane | 400 mg | † |
| eternalyoung®†† Botanical Blend | 225 mg | † |
| Hyaluronic Acid | 120 mg | † |
Other ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Ascorbyl Palmitate.
Directions: Suggested Use: Take 2 capsules daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749016007 · Label source: Reverseagelab · Report a label change
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More younger-looking skin for women products
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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