Thorne Vitamin D/K2 Liquid Review
Vitamin D + K2 Liquid from Thorne is presented as a convenient combination of vitamin D and vitamin K for bone, cardiovascular, and immune support. The page states that the product promotes bone health, healthy immune function, and cardiovascular health, and that the combination of vitamin D3 and K2 provides greater benefits together than either does individually. The details section explains that vitamin D3 and K2 work together to benefit bone health, cardiovascular support, and healthy immune function. Maintaining an optimal level of vitamin D throughout all stages of life is described as helping maintain strong bones and healthy immune function. Adding vitamin K2 is described as helping move calcium to the bones to protect soft tissues, such as the arteries and kidneys, from calcification. The listed benefits include supporting a healthy heart and blood circulation, promoting bone health and calcium absorption, benefiting immune function, and providing advanced bone health support. The listed features include that the vitamin K2 in this formula is MK-4, described as the most clinically studied form of vitamin K; that vitamin D in its D3 form is described as more potent and better absorbed than its D2 form; that the self-dispensing top provides an accurate, safe, and individualized dose by metering individual drops; and that the liquid is in medium chain triglyceride oil and preserved with mixed tocopherols. The page says the product has been third-party tested and certified to verify that what is in the package matches the label and to confirm it contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. Serving size is listed as 2 drops with 600 servings per container, and the price is listed as $34 for 1200 drops. A subscription option lists $30.60 with a 10 percent discount. Warnings state that the product is contraindicated in individuals with a history of hypersensitivity to its ingredients, that pregnant individuals should consult a health-care practitioner, that vitamin K can interfere with a med drugs such as a med, and that the product is not intended for children under 12 months. The FAQ section says the formula is ideal for those wanting to support bone, cardiovascular, and immune health, and recommends testing vitamin D levels before supplementation. It also explains that Thorne tests each ingredient for identity, purity, and potency, and that vitamin D3 is generally considered the preferred form because it is more effective at raising and maintaining vitamin D levels in the blood than D2. The FAQ further describes vitamin D and K2 as working together, with vitamin D enhancing calcium absorption and retention and vitamin K2 helping direct calcium into bones and teeth and away from soft tissues. Individuals taking meds are advised to consult a health-care professional before using vitamin K supplements.
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Study, Trial or Testing Result Summary
Members Only85 human studies · 42 improved
Both ingredients in this liquid are at or above the doses used in studies. Vitamin K2, at 200 micrograms here, has the stronger support for bone health. Pooled analyses of postmenopausal women with thinning bones found it raised spine bone density more than control, with no serious side effects [1][2]. The spine benefit showed up in women with thinning bones but not in those without, and fewer fractures appeared only after one study was left out [3]. In healthy postmenopausal women, 180 micrograms a day for three years slowed bone loss at the spine and hip neck [4]. A one-year trial found 90 micrograms a day reduced hip bone loss in postmenopausal women but not in men [5]. Vitamin D, at 25 micrograms here, gives mixed results. One review found 700 to 800 units a day cut hip fractures by 26%, while 400 units did not help [6]. Other reviews found no clear drop in fractures [7][8]. A large review of women with thinning bones found calcium plus vitamin D slightly improved pelvic bone density but did not reduce fractures [9]. Animal and cell studies are never counted.
See all 85 studies →Hide the studies
- In five observational studies of about 81,000 people, those with the highest dietary vitamin K1 intake had a 22% lower fracture risk than those with the lowest intake; this was diet, not vitamin K2 supplements.Vitamin K intake and the risk of fractures: A meta-analysis.
- In 11 trials of 43,869 postmenopausal women with osteoporosis, calcium plus vitamin D modestly improved pelvic bone density but not spine, neck of femur or total hip density, and did not reduce fractures.The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausa…
- This review of smartphone apps for osteoporosis self-management did not test vitamin D supplements and found no significant effect on vitamin D intake.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- In trials of older adults, 700 to 800 IU a day of vitamin D cut hip fracture risk by 26% and other nonvertebral fractures by 23%, while 400 IU a day gave no significant benefit.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
- Across nine trials with 6853 postmenopausal women with osteoporosis, vitamin K2 raised lumbar and forearm bone density more than control, with more mild side effects but no serious ones linked to it.Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and…
- Across 19 trials with 6759 postmenopausal women, vitamin K2 improved spine bone density in women with osteoporosis but not those without, and fracture reduction was only significant after excluding one study.Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of…
- Across 16 trials with 6425 postmenopausal women, vitamin K2 improved lumbar spine bone density, and fractures fell only after excluding one study, with no difference in side effects.Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-anal…
- Across 43 trials in 5,184 postmenopausal women, vitamin K gave the largest rise in a bone-formation marker (bone alkaline phosphatase), and vitamin K combined with vitamin D most effectively raised two other bone-formation markers.Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.
- Across nine trials with 2570 postmenopausal women with osteoporosis, vitamin K2 improved most bone turnover markers, though bone density and fracture benefits were not measured.The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a…
- Across 10 trials with 1346 people, vitamin K plus calcium raised lumbar spine bone density, with a clearer effect for vitamin K2 than for vitamin K1.The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled…
- Across eight trials with 971 people, vitamin K combined with vitamin D increased total bone density, with a stronger effect when vitamin K2 was used at under 500 micrograms a day.The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials…
- Across nine studies, vitamin D3 did not significantly reduce nonvertebral or vertebral fractures versus placebo or calcium alone, with only a borderline trend toward fewer falls.The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis.
- Across 13 trials, vitamin K reduced bone loss, and seven Japanese trials of menaquinone found far fewer vertebral, hip and other non-spine fractures.Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
- A pooled analysis of trials in middle-aged and older adults found vitamin K supplements raised lumbar spine bone density and improved bone protein carboxylation, but did not change other bone turnover markers.Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged a…
- A review of 13 trials found small studies showed little or modest bone density benefit, while there was some evidence of fewer vertebral fractures in postmenopausal women, and no evidence for men.Menatetrenone for the treatment of osteoporosis.
- In 23 trials of 1,209 kidney transplant recipients, vitamin D analogues (2 trials, 51 patients) improved lumbar spine and femoral neck bone density versus no treatment, but no trial showed fewer fractures.Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled …
- In 18 small trials of 576 children with chronic kidney disease, vitamin D preparations lowered parathyroid hormone levels, but there were few data on growth or bone deformities and no clear differences between preparations.Interventions for metabolic bone disease in children with chronic kidney disease.
- Three small trials in 70 people with cystic fibrosis gave very low-quality evidence, so it is uncertain whether vitamin K changes bone density, though blood vitamin K rose and undercarboxylated osteocalcin fell.Vitamin K supplementation for cystic fibrosis.
- One small trial of 39 people with sickle cell disease found vitamin D3 for six weeks raised blood vitamin D and reduced pain days versus placebo, but no bone outcomes were reported and the evidence was low quality.Vitamin D supplementation for sickle cell disease.
- In nine trials of postmenopausal women without osteoporosis, vitamin D raised blood vitamin D and improved some bone remodeling measures, but only one study found fewer fractures, so a fracture benefit could not be confirmed.Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal wom…
- A review of randomized trials in women found vitamin K2 results for bone density and fractures were promising, though study limitations mean confirmation is needed.Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled tria…
- Seven trials in postmenopausal women lasting 2 years or more found high-dose vitamin K1 or K2 lowered undercarboxylated osteocalcin, improved femoral neck bone strength and reduced clinical fractures, though bone density changed little.High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature.
- In four mostly small open-label trials of 45 mg vitamin K2 in Japanese women with osteoporosis, smaller trials showed fewer spine fractures but the larger trial did not, and non-spine fractures did not differ.Vitamin K to prevent fractures in older women: systematic review and economic evaluation.
- In children on long-term a med treatment, vitamin K2 combined with alfacalcidol preserved bone density, but calcium with alfacalcidol prevented bone loss better than menatetrenone.Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review.
- This review of observational and intervention studies found that the evidence on vitamin K, including vitamin K2 supplements, and bone health, bone density and fractures is conflicting and unclear.Vitamin K and osteoporosis: Myth or reality?
- A review of ten studies on vitamin K for osteoporosis in postmenopausal women reported no outcome results in its abstract.The Anti-osteoporosis Effects of Vitamin K in Postmenopausal Women.
- In 500 elderly women with Alzheimer disease who all took 1000 IU of vitamin D2 plus calcium, adding risedronate for 18 months raised bone density 4.1% and cut hip fracture risk compared with placebo, but vitamin D itself was not tested alone and the paper was retracted.The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Al…
- Children whose mothers took 1000 IU of vitamin D3 daily during pregnancy had higher whole-body bone mineral content and density at ages 6-7 than children whose mothers took placebo.Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled…
- In 452 older men and women taking calcium and vitamin D, 500 micrograms a day of vitamin K1 for 3 years did not change bone density at the hip or spine compared with no vitamin K1.Effect of vitamin K supplementation on bone loss in elderly men and women.
- In 441 young Chinese women given milk powder with 1000 mg calcium and 80 mcg vitamin K1 or nothing for 2 years, bone density and bone turnover markers showed little difference between groups.Milk supplementation and bone health in young adult chinese women.
- In 440 postmenopausal women with low bone density, 5 mg a day of vitamin K1 for 2 to 4 years did not change bone density, but fewer women had clinical fractures (9 versus 20 on placebo).Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
- In 381 healthy postmenopausal women taking calcium and vitamin D, 45 mg a day of vitamin K2 (MK4) or 1 mg of vitamin K1 for 12 months lowered undercarboxylated osteocalcin but did not change bone turnover or bone density compared with placebo.Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in heal…
- In 379 healthy older adults, 500 mcg per day of phylloquinone for three years did not change inflammation or bone-related cytokine levels compared with no supplement.Vitamin K, circulating cytokines, and bone mineral density in older men and women.
- In 325 postmenopausal women given 45 mg a day of vitamin K2 (MK-4) for three years, bone mineral content and femoral neck width increased and hip bone strength was maintained compared with placebo, though standard bone density did not change.Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.
- In 311 middle-aged and older adults, 90 micrograms a day of vitamin K2 for one year reduced femoral neck bone loss in postmenopausal women compared with placebo, with no effect in men and no added benefit from calcium and vitamin D3.Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized C…
- In 244 healthy postmenopausal women, 180 micrograms a day of vitamin K2 (MK-7) for three years slowed bone density loss at the lumbar spine and femoral neck, but not the total hip, and reduced loss of vertebral height compared with placebo.Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
- In 242 elderly men with Parkinson disease who all took 1000 IU of vitamin D2, adding risedronate for 2 years raised bone density, but vitamin D was not compared against placebo and the paper was retracted.Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
- In 219 healthy young and older adults, 1000 micrograms a day of vitamin K1 (not K2) for two weeks lowered undercarboxylated osteocalcin but did not change other bone turnover markers.Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elde…
- In postmenopausal women aged 50 to 60, 1 mg of vitamin K1 daily plus minerals and vitamin D for 3 years reduced femoral neck bone loss compared with placebo, but had no effect on lumbar spine bone density.Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.
- In Japanese adults taking 100 micrograms of menaquinone-7 daily for 12 weeks, osteocalcin became more fully activated compared with placebo, and doses of 100 micrograms or more were suggested as effective.Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized C…
- In 148 postmenopausal women with low bone density taking 375 mcg of vitamin K2 (menaquinone-7) daily for 12 months, the internal structure of tibia bone was preserved compared with placebo, while bone density showed no difference.Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postm…
- In 148 postmenopausal women taking 375 mcg of vitamin K2 (menaquinone-7) daily for 12 months, an inactive form of bone protein fell sharply and a blood marker of metabolic health rose compared with placebo, but insulin sensitivity did not change.Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women:…
- In 142 postmenopausal women with osteopenia taking 375 mcg of vitamin K2 (MK-7) or placebo daily for 3 years, bone density and bone structure changes did not differ between the groups, although MK-7 raised carboxylated osteocalcin in the blood.The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-ye…
- In 122 postmenopausal women eating vitamin D enriched salmon twice weekly for 12 weeks, bone breakdown markers improved compared with a low vitamin D intake, though the amount of vitamin K was not stated.Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention…
- In 110 healthy children and adults, menaquinone-7 supplements helped most those with the greatest vitamin K deficiency, and adults over 40 may benefit most.Vitamin K status in healthy volunteers.
- In 105 women with osteoporosis taking meds, 45 mg a day of menatetrenone for 18 months did not change bone density compared with placebo.Read the study on PubMed (37338608) →
- In 94 lung and heart transplant recipients taking 180 mcg of vitamin K2 or placebo for 1 year, lumbar spine bone density was higher with vitamin K2 (borderline significant), with benefit seen in lung recipients but not heart recipients.Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.
- In 92 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone for 2 years increased lumbar spine bone density more than calcium alone.Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopa…
- In adults with type 2 diabetes and heart disease, 360 mcg of vitamin K2 daily for 6 months did not slow bone mineral density decline or arterial calcification compared with placebo.Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes melli…
- In 63 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone with calcium for 48 weeks increased lumbar spine bone density more than placebo with calcium.Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
- In 55 healthy prepubertal children, 45 mcg per day of menaquinone-7 for eight weeks improved osteocalcin carboxylation compared with placebo.The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children.
- In 50 women with cirrhosis, vitamin K2 (menatetrenone) over 2 years prevented lumbar spine bone loss, with bone density rising 0.1% at 1 year and falling only 0.5% at 2 years while the control group lost 2.2% and 4.6%.Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver.
- In 40 healthy postmenopausal Japanese women taking 1.5 mg of menaquinone-4 daily for 4 weeks, osteocalcin activation improved compared with placebo, with the largest change at 2 weeks.Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
- In 40 hemodialysis patients with low parathyroid hormone, 45 mg per day of menatetrenone for one year improved bone remodeling markers compared with a control group.Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level.
- In 34 early postmenopausal women with low bone density taking 45 mg of vitamin K2 daily for 2 years, a marker of vitamin K status improved, but bone density results were not reported as a clear gain and there was no placebo comparison.Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women.
- In 33 postmenopausal women taking a combination of vitamin K1 (1000 micrograms daily), vitamin D3, hop acids, and berberine for 14 weeks, a bone turnover marker (osteocalcin) fell by about 31% while placebo rose, though the vitamin K1 effect cannot be separated from the other ingredients.Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopa…
- In a small trial of 29 children with leukemia, those given 100 mcg of vitamin K2 (menaquinone-7) with vitamin D3 during chemotherapy showed early bone-protective changes over about 6 months compared with children receiving chemotherapy alone.Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective…
- In 20 patients starting a med treatment, 15 mg per day of menatetrenone for one year was linked to no significant bone density loss, while the group without it lost lumbar spine bone density.Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG).
- In 20 postmenopausal women with osteoporosis and prior wrist fractures, vitamin K over 2 weeks corrected the carboxylation defect in osteocalcin, with a similar result after vitamin K plus vitamin D, but bone density was not reported as an outcome.Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation.
- In 16 adults on long-term meds for neuromuscular disorders, adding vitamin K2 to risedronate for one year did not produce any extra change in bone turnover markers compared with risedronate alone.Read the study on PubMed (20190467) →
- In 15 young adults on a crossover diet study, a hydrogenated form of vitamin K1 (dihydrophylloquinone) at 200 mcg daily for 10 days was less absorbed and had no measurable effect on bone formation or breakdown markers, unlike regular vitamin K1.Effects of a hydrogenated form of vitamin K on bone formation and resorption.
- In young Indian women taking a protein drink fortified with calcium, vitamin D and 55 mcg of vitamin K for 6 months, bone turnover markers moved in a favorable direction compared with a low-protein placebo drink.Randomised Controlled Trial of Nutritional Supplement on Bone Turnover Markers in Indian Premenopausal Women.
- In healthy women given 1 mg of vitamin K daily, bone-related blood markers shifted and urinary calcium fell about 30% in women who lost calcium quickly, while the placebo-controlled trial in postmenopausal women ran for 3 months.Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss.
- In 82 premenopausal women, adding 80 micrograms of vitamin K1 to calcium-fortified milk for 16 weeks improved vitamin K levels but did not reduce bone turnover more than milk alone.Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in pr…
- In 69 patients with osteopenia or osteoporosis having lumbar spine surgery, adding vitamin K2 to vitamin D3 and calcium for 6 months increased complete spinal fusion rates compared with the control group.Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative…
- In 60 people with autoimmune diseases taking meds and meds, menatetrenone raised bone formation markers during the first month, but bone density and fracture rates did not differ from those not taking it after about 1.5 years.Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases.
- In 21 women with anorexia nervosa followed for about 0.9 years, those taking menatetrenone lost less lumbar bone density (2.8%) than those not taking it (6.9%).Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa.
- In 20 people with kidney disease starting prednisolone, adding 45 mg a day of menatetrenone for 10 weeks prevented the spine bone density loss seen with prednisolone alone.Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chro…
- In 12 healthy young adults, 90 mcg of vitamin K2 (menaquinone-7) added to daily olive oil for 2 weeks increased the active form of bone protein and decreased the inactive form compared with baseline.Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation.
- In healthy volunteers, MK-7 from natto was absorbed well, stayed in the blood much longer than vitamin K1, and carboxylated osteocalcin more completely; preparations of 50 mcg daily or more may interfere with meds.Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
- In an open-label 2-year study of 241 osteoporosis patients, those taking 45 mg of vitamin K2 daily had fewer new fractures and lost less spine bone density than the untreated control group.Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
- In 109 postmenopausal women with osteoporosis, 45 mg of menatetrenone daily for six months raised the active form of osteocalcin and lowered its inactive form compared with calcium, but urinary bone breakdown markers also rose after six months, and bone density was not measured.Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover …
- In 20 children with thalassemia taking 50 mcg of menaquinone-7 plus calcitriol for 1 year, lumbar spine bone density and Z-score improved, though this was an uncontrolled pilot study.The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy.
- In 20 severely disabled children and adults with bone thinning, bone density rose after 4 months of oral vitamin K2 and stayed higher through 12 months, though there was no control group and the dose was not stated.[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
- In 15 healthy young men given menaquinone-4 in steps of 300, 600, 900 and 1500 mcg daily over 5 weeks, blood levels of活性 osteocalcin rose at 900 mcg daily or more, and the inactive form fell at 600 mcg daily or more.Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response st…
- In a Japanese cohort of 944 women followed for 3 years, eating more natto was linked to less bone loss, especially in postmenopausal women.Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-B…
- In Tuscany, Italy, most people who broke a hip from 2011 to 2015 were not taking vitamin D supplements, and only 30-35% were on cholecalciferol one year after the fracture; no bone outcome was measured against a comparison group.The use of cholecalciferol in patients with hip fracture.
- In 211 patients with chronic pancreatitis, vitamin K deficiency was the only factor linked to osteoporosis in men, with 32 percent of patients found to be vitamin K deficient.Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE …
- In a 2-year cross-sectional study of 116 pre- and post-menopausal obese and non-obese women, daily vitamin D and calcium intake was low and osteoporosis was less common in obese women, though blood vitamin D levels were within normal range.Dietary Pattern and Bone Health in Pre and Post-menopausal Obese Women.
- In 113 postmenopausal women, lower vitamin K status was linked to lower bone mass only in women who also had aortic calcification.Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study.
- In 16 Crohn's disease outpatients with a med-related bone loss, the vitamin K2 group showed no change in bone density after one year, while the alendronate group improved.Read the study on PubMed (19525577) →
- In 8 stable dialysis patients taking 45 mg of menatetrenone (vitamin K2) daily for 12 months, bone mineral density stayed at the same level, though some blood bone markers changed in mixed directions and there was no control group.Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients.
- In 8 female elite athletes taking 10 mg of vitamin K daily for one month, bone formation markers rose 15 to 20 percent and bone breakdown markers fell 20 to 25 percent in the low-estrogen group, with no control group.Improved bone metabolism in female elite athletes after vitamin K supplementation.
- In children with cystic fibrosis, higher vitamin K intake was suggested to bring bone and health benefits, based on bone markers at different doses.Vitamin K supplementation in cystic fibrosis.
- In Japanese patients with osteoporosis, vitamin K2 combined with EHDP worked better than either alone, while vitamin D3 plus vitamin K2 had little effect on spine bone density.[EHDP + vitamin D3 or vitamin K2].
Review Totals and Summary
Members Only7,180 reviews · 80% positive
This Thorne Vitamin D/K2 Liquid has garnered about 7180 ratings across various stores, presenting a mixed but generally positive picture for potential buyers. Many customers praise its effectiveness and the convenience of its liquid form, though a significant number express frustration with its dispensing mechanism. **What it did for them** Many users report positive health impacts from taking this supplement. Some notice a difference quickly, with one user stating they "Can feel the difference almost immediately." Others experience increased energy, with a reviewer noting, "I am finding that I have more energy which is the biggest benefit." For some, it's the only D3 supplement they can tolerate, avoiding issues like hot flashes experienced with other products. Reviewers who trust the Thorne brand and are vitamin D deficient often plan to continue using it, citing its perceived effectiveness and bioavailability. **Form and Ease of Use** The liquid form is a major draw, especially for those who "can't swallow pills." Many find it "so easy to take" and appreciate that it is "completely flavorless as near as I can tell." This neutrality allows it to mix smoothly into food and drink, making it effortless to integrate into a daily routine. This aspect is frequently highlighted as a key benefit, particularly for individuals who struggle with traditional pill supplements. **Dispenser Complaints** The most common and significant complaint revolves around the bottle's dispensing system. Many find it "Hard to dispense," with drops coming out very slowly, or not at all, making it feel "like an eternity for even one drop to come out." Users report difficulty seeing how many drops are dispensed, leading to uncertainty about correct dosage. Some describe it as the "most frustrating vitamin delivery system ever," with drops splattering onto faces or clothes, rather than reliably reaching the mouth. Several reviewers suggest a standard squeeze dropper would be a much better alternative, expressing frustration that the company's design team hasn't addressed this. Occasional packaging issues, such as broken seals and leakage, were also mentioned, though one buyer considered it "not a big deal." **Value for Money** One reviewer explicitly mentioned the product as "cost effective," suggesting that some users perceive it as a good value given its benefits and form. **Who it suits and who it did not** This liquid supplement seems well-suited for individuals who struggle with swallowing pills or have experienced adverse reactions like hot flashes with other D3 supplements. It appeals to those seeking an easy-to-integrate, flavorless option for their daily routine. However, it may not suit those who require precise dosing or who are easily frustrated by difficult-to-use dispensers. Many users, despite acknowledging the product's benefits, state they "will not repurchase" due to the dispenser issues, while others are willing to tolerate the frustration for the perceived benefits.
Biohacker Summary
Members Only9 of 10 recommend it
The panel leans toward vitamin D, which is not a minor ingredient here in the panel's discussion but is listed as a smaller ingredient in this product, and it drew comments from all ten of them. Four of them said they take it themselves, and three of those take 5,000 IU of D3 in the morning, while one has taken D3 with K2 for over a decade. They give reasons such as immune support, brain and mood, muscle, sperm health, and low sun exposure, and one suggested checking blood levels first. One said to take at least 10,000 IU a day, another said it only helps most people if they are deficient, and one said the standard 600 IU recommendation leaves many people short. Vitamin K2 is also a smaller ingredient in this product; several on the panel recommend it with vitamin D for bone health and calcium handling, and two take 90 to 100 mcg in the morning.
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Dr. Eric Berg · Vitamin D · neutral
- Lists Vitamin D as an ingredient found in sardines.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Recommends pairing Vitamin D3 with K2, stating that K2 helps keep calcium out of soft tissues.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Recommends focusing on vitamin K2 to support stronger bones if a neck hump is associated with osteoporosis.
- Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- States that magnesium is needed to absorb vitamin D.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Discusses foods that contain Vitamin K2.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- States that vitamin K2 is a key nutrient for teeth, as its primary job is to push calcium into bones and teeth, and recommends a supplement dose of 1 to 200 micrograms per day, paired with vitamin D.
Dr. Rhonda Patrick · Vitamin D · neutral
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Mentions vitamin K as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Mentions that kale delivers vitamin K, a micronutrient many diets fall short on.
- Rhonda takes 100 mcg of Vitamin K2 (MK-7) daily for general health.
Dave Asprey · Vitamin K · recommends
- Explains that Vitamin K2 acts as a traffic cop for calcium, waving it into bones and away from arteries, and that grass-fed butter is one of the only foods with a real amount of K2.
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
- Recommends Vitamin K2, stating it supports healthy calcium metabolism.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends adding vitamin K2 to vitamin D supplementation.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Mentions that natto is a good source of vitamin K2, which is probably its primary benefit.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
Thomas DeLauer · Vitamin K · recommends
- Recommends taking Vitamin K2 with Vitamin D3 in the morning, along with morning fats, to ensure calcium is directed to the bones and not deposited in arteries or soft tissue.
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Recommends getting vitamin D, suggesting it can be obtained while walking.
- States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
- Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
- Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
- Notes that grass-fed butter provides more Vitamin K2, which plays a role in directing calcium towards bones instead of arteries, contributing to bone health.
- Advises checking multivitamins because many contain 100, 200, or 300% of the daily value of selenium, which can contribute to excessive intake.
Dr. Mark Hyman · Vitamin D · uses
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
- Takes 100 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning for overall health.
- States that green leafy vegetables are great sources of vitamin K.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
- Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
- Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Vitamin K2 as one of 15 supplements backed by human studies.
- Lists leafy greens as a source of Vitamin K1.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Thinks vitamin K2 has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
Ben Greenfield · Vitamin D · recommends
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
- Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends taking vitamin K complex as a co-factor to increase vitamin D absorption.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
- Recommends using hormone building blocks like vitamin D for hormone optimization.
- Notes that vitamin D deficiency is the most common deficiency.
- Lists vitamin D3 and K2 for the immune system as a recommended intervention on the True Age test.
Bryan Johnson · Vitamin K · uses
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning.
Andrew Huberman · Vitamin D · neutral
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- He takes 90 mcg of Vitamin K2 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
- Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
- Takes 100 mcg of Vitamin K2 in the morning to maintain levels.
RAL Summary
Members OnlyTier 2 for Bone Health
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system
Combine with: To further enhance bone health alongside Vitamin D and K2, consider supplementing with Calcium, as Vitamin D is crucial for its absorption into the bones. Magnesium is another vital mineral that works synergistically with both Vitamin D and K2, playing a role in bone formation and helping to activate Vitamin D. Additionally, a high-quality collagen supplement can provide the necessary protein matrix for strong bones, complementing the mineral deposition facilitated by D and K2.
Possible side effects: Studies reported more mild side effects with vitamin K2 but no serious ones. Reviewers mainly complained about the hard-to-use dropper, not about side effects.
Supplement Facts
Vitamin D3 25 mcg · Vitamin K2 200 mcg
| Vitamin D3 | 25 mcg | |
| Vitamin K2 (Menatetrenone) | 200 mcg |
Other ingredients: Mixed Tocopherols, Medium Chain Triglycerides.
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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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