Turmeric Curcumin Supplement 2365mg - with Ginger & Black Pepper - 120 Caps Review
The Turmeric Curcumin Supplement 2365mg - with Ginger & Black Pepper - 120 Caps is a meticulously formulated dietary supplement designed to harness the potent health benefits of turmeric, enhanced by the synergistic inclusion of ginger and black pepper. This comprehensive complex aims to support overall well-being, focusing particularly on inflammatory response, joint health, and antioxidant defense. Each serving, consisting of three capsules, delivers a robust blend of 2100mg of Turmeric Root Powder and 150mg of concentrated Turmeric Extract, standardized to 95% curcuminoids, providing approximately 142.5mg of these key active compounds. At its core, this supplement leverages curcumin, the primary biologically active polyphenol found in turmeric, renowned for its powerful anti-inflammatory and antioxidant properties. Curcumin works by influencing multiple molecular targets involved in inflammatory pathways, helping to modulate the body's natural inflammatory response at a cellular level. Its antioxidant capabilities enable it to neutralize free radicals, thereby protecting cells from oxidative damage and supporting cellular health. A critical aspect of this formulation is the inclusion of 10mg of Black Pepper Extract, which contains piperine. Curcumin, while highly beneficial, is known for its poor bioavailability and rapid metabolism in the body when consumed alone. Piperine addresses this challenge by significantly enhancing curcumin absorption, with studies suggesting an increase in bioavailability by up to 2000%. This mechanism allows the body to utilize the curcumin more effectively, maximizing its therapeutic potential. Furthermore, the supplement incorporates ginger, a botanical closely related to turmeric, which contributes its own array of health benefits. Ginger contains active compounds like gingerols and shogaols, which possess anti-inflammatory and antioxidant properties, complementing those of curcumin. Ginger also traditionally supports digestive comfort and can work synergistically with turmeric to promote a balanced inflammatory response throughout the body. This combination is particularly beneficial for supporting joint comfort, flexibility, and mobility, as well as bolstering the immune system. Manufactured in a GMP-certified facility in the USA using premium, non-GMO ingredients, this supplement prioritizes purity, safety, and consistent potency. The capsules are designed for easy ingestion, offering a convenient way to integrate these powerful botanicals into a daily wellness routine for comprehensive joint, immune, and antioxidant support.
Study, Trial or Testing Result Summary
Members Only29 human studies · 25 improved
Turmeric is the main ingredient here at a full dose, and it has strong study support for joint comfort. A pooled analysis of 39 trials with 4599 people with knee arthritis found curcumin improved some pain, stiffness or function outcomes compared with placebo, with no added side effects [1]. Another pooled analysis of 23 studies with 2175 people found less pain and less need for rescue meds [2]. In rheumatoid arthritis, six studies with 539 people showed fewer swollen and tender joints [3]. In 106 adults with knee pain, 250 milligrams a day of a turmeric extract for 90 days reduced pain and improved walking and stair climbing [4]. The turmeric extract here is 150 milligrams per serving, which reaches the studied amount only at two servings a day. Not every result was positive: a combination product did no better than placebo in 84 people [5], and many trials were small and of low quality [6]. Black pepper extract has never been tested alone for joints; mixes containing it did not lower inflammation markers more than placebo [7]. Ginger is named on the listing, but no ginger amount appears on the label. Animal and cell studies are never counted.
See all 29 studies →Hide the studies
- In a pooled analysis of 39 trials with 4599 people with knee osteoarthritis, curcumin improved some pain, stiffness or function outcomes compared with placebo, though Boswellia ranked best, and no added side effects were seen.Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.
- In a pooled analysis of 47 trials with 3852 people with rheumatoid arthritis, dietary polyphenols including curcumin improved disease activity, inflammation and oxidative stress without more side effects.Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomiz…
- In a pooled analysis of 29 trials with 2396 people with arthritis, curcumin or turmeric extract at 120 to 1500 mg for 4 to 36 weeks eased pain and inflammation and was safe, though trial quality was low.Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-An…
- In a pooled analysis of 23 studies with 2175 people with knee osteoarthritis, curcumin lowered pain and total WOMAC scores and the need for rescue medication compared with placebo, with fewer adverse reactions than meds.Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
- In a pooled analysis of 21 trials with 1705 people with knee osteoarthritis, curcumin lowered blood CRP and TNF-alpha compared with placebo but did not change ESR, IL-1beta, IL-6 or PGE-2.Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-…
- In a pooled analysis of 15 trials with 1621 people with osteoarthritis, turmeric extract and curcumin reduced pain, stiffness and function scores compared with placebo with similar side effects, and use beyond 12 weeks was recommended.The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and met…
- Across 12 studies with 724 curcumin users and 714 controls with osteoarthritis, curcumin improved pain and function compared with placebo but not compared with active treatments such as meds.A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
- In a pooled analysis of 5 studies with 599 people with osteoarthritis, curcumin improved WOMAC and pain scores, with side effects not higher than with a med.Efficacy and side effect of curcumin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trial…
- In a pooled analysis of six publications with 539 people with rheumatoid arthritis, curcumin lowered ESR, disease activity score, and swollen and tender joint counts compared with controls.Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.
- Across 8 trials, turmeric extract providing about 1000 mg of curcumin per day reduced arthritis pain and stiffness compared with placebo, though the authors judged the evidence not yet definitive.Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta…
- In a review of 69 placebo-controlled trials of supplements for hand, hip or knee osteoarthritis, curcumin and turmeric extract had large short-term pain-relief effects, but no supplement had clinically important effects at long term and evidence quality was often very low.Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
- Across 21 trials, turmeric and curcumin supplements were effective adjuvants for musculoskeletal and joint health with few side effects, and a 250 mg daily dose of a water-dispersible turmeric extract appeared more effective than other curcumin products.Safety and Efficacy of Turmeric (Curcuma longa) Extract and Curcumin Supplements in Musculoskeletal Health: A Systematic…
- A pooled analysis of 11 meta-analyses of randomized trials found curcumin supplements significantly reduced knee osteoarthritis pain, stiffness and function scores.The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.
- Across 17 studies, all turmeric preparations used alone reduced knee osteoarthritis pain compared with placebo, though the certainty of the evidence was low.Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis.
- Across seven randomized trials in adults with rheumatoid arthritis, curcumin lowered joint disease activity score, rheumatoid factor, blood sedimentation rate and C-reactive protein compared with placebo or standard care.Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
- A review of 161 meta-analyses of randomized trials found curcumin and related ginger-family plants clearly relieved osteoarthritis pain and related conditions, though the authors say higher-quality research is still needed.Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and met…
- This review found mostly laboratory and animal studies and only one human study, in which curcumin improved morning stiffness, walking time and joint swelling in people with rheumatoid arthritis.Curcumin and rheumatoid arthritis: A systematic review of literature.
- Across 17 randomized trials lasting 4 weeks to 8 months, various curcumin formulations significantly improved pain and overall WOMAC scores in people with osteoarthritis without severe side effects, with better-absorbed forms tending to work better.A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.
- In a 3-month placebo-controlled trial of 162 people with hand osteoarthritis, a combined turmeric and Boswellia extract reduced pain more than placebo, with no significant difference in side effects.Effect of a combination of C. longa and B. serrata extracts on hand osteoarthritis. Results of a double-blind, randomize…
- In 139 people with knee osteoarthritis, 1500 mg curcumin daily for 28 days relieved pain about as well as the drug diclofenac, with fewer side effects (13% vs 38%), and this was an open-label comparison without placebo.Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.
- In 106 adults with chronic knee pain, 250 mg of a water-dispersible turmeric extract daily for 90 days reduced pain scores more than placebo and improved walking and stair-climbing times.A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turm…
- In 84 adults with symptomatic knee osteoarthritis, a daily combination containing 500 mg curcumin for 12 weeks reduced knee pain no more than placebo did.Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, pl…
- In 80 adults with knee osteoarthritis, 400 mg of curcumagalactomannosides plus 500 mg glucosamine twice daily for 12 weeks improved pain, stiffness and walking compared with chondroitin plus glucosamine, and lowered inflammatory blood markers more than the comparison group.Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chond…
- In 70 people with knee osteoarthritis and joint swelling, turmeric extract for 12 weeks reduced knee pain more than placebo (9.1 mm on a 100 mm scale) but did not reduce joint swelling or change cartilage.Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A R…
- In 60 people with chronic knee osteoarthritis, a turmeric, black pepper and ginger mix taken for 4 weeks lowered an inflammation chemical (PGE2) similarly to the drug a med, with no difference between groups.Read the study on PubMed (32180294) →
- In 48 women with rheumatoid arthritis, 500 mg of curcumin daily for 8 weeks raised antioxidant capacity, lowered an oxidative stress marker within the curcumin group, and reduced joint tenderness, swelling, pain and disease activity more than placebo.The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in w…
- In 40 adults with mild to moderate knee osteoarthritis, 1,500 mg of curcuminoids a day for 6 weeks was followed by clinical symptom improvement and lower blood inflammation markers, though these changes did not differ significantly from placebo.Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from…
- In 40 people with mild-to-moderate knee osteoarthritis, 1500 mg of curcuminoids with 15 mg of piperine daily for 6 weeks improved blood antioxidant enzyme activity and lowered a marker of oxidative damage compared with placebo.Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial.
- In 60 adults with knee or hip osteoarthritis, one month of Cartilox alongside physical therapy reduced pain and improved daily function more than physical therapy alone, with no adverse events recorded.[Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evalua…
Review Totals and Summary
Members OnlyWhat buyers say
Customer feedback for the Turmeric Curcumin Supplement 2365mg - with Ginger & Black Pepper - 120 Caps consistently highlights several qualitative themes, primarily revolving around its efficacy for joint health and inflammation, ease of use, and perceived quality. Many users express significant satisfaction with the supplement's ability to alleviate joint pain and stiffness, reporting improved mobility and comfort in their daily activities. Individuals dealing with morning joint stiffness or those engaged in active lifestyles, such as runners or DIY enthusiasts, frequently praise its effectiveness in keeping them moving freely and feeling their best. The anti-inflammatory benefits are also a recurring positive, with customers noting a reduction in overall inflammation. Beyond its therapeutic effects, the product receives commendation for its user-friendly design. Customers often describe the capsules as "small and slick," making them exceptionally easy to swallow without discomfort. A notable point of appreciation is the absence of an unpleasant aftertaste or the common "spice burp" sometimes associated with herbal supplements, which contributes to a more pleasant daily experience. The supplement is also frequently cited as being gentle on the digestive system, avoiding the gastrointestinal upset that some individuals experience with other formulations. The quality and sourcing of ingredients are also strong positive themes. Users value that the product is made in the USA, in a GMP-certified facility, and uses non-GMO ingredients, instilling confidence in its purity and safety. The inclusion of black pepper extract for enhanced absorption is often recognized as a key factor contributing to the supplement's effectiveness, demonstrating an understanding of curcumin's bioavailability challenges. While some general information about turmeric supplements mentions potential side effects if capsules are opened, direct feedback for this specific product indicates that if the powder is mixed with food or drink, the taste may be naturally strong or spicy, but this is presented as a preference rather than a complaint. Overall, the prevailing sentiment among customers is one of appreciation for a high-quality, effective, and easy-to-take supplement that delivers tangible benefits for joint comfort and inflammatory support.
Biohacker Summary
Members Only9 of 10 recommend it
Turmeric is the main ingredient, and the panel leans positive: three of ten recommend it, four use it, and three warn. People take it mostly for inflammation, joint pain and knee recovery, and some also for liver support, with one person using one gram a day and others simply adding it to bone broth or food. Several say to pair it with black pepper to help absorption, and a few prefer well-absorbed forms of curcumin, the active compound in turmeric, over plain powder. The cautions are to stop it before surgery, that it is very high in oxalate in large amounts, and that bioavailable forms may not suit people with low DHT or insensitive androgen receptors; one person also advises avoiding curcumin in pregnancy and another stopped taking it for lack of evidence. Black pepper and curcumin are smaller ingredients in this product, and one panelist notes black pepper can bother people who are sensitive to it.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Turmeric · recommends
- Dr. Eric Berg recommends pairing turmeric with black pepper to improve curcumin absorption.
- Dr. Eric Berg recommends pairing black pepper with turmeric to improve curcumin absorption.
- States that one cup of turmeric water could have surprising benefits for health.
- Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
- Notes that black pepper aids in the absorption of Curcumin.
- Notes that Curcumin barely absorbs without black pepper.
- Dr. Eric Berg recommends adding turmeric to eggs to support satiety, antioxidant potential, cardiovascular, and liver health.
- Dr. Eric Berg recommends adding black pepper to eggs to support satiety, antioxidant potential, cardiovascular, and liver health.
- Recommends turmeric for its chelation abilities and its ability to turn up the body's detoxification genes.
- Mentions turmeric as a food that black cumin seed oil outperforms in reducing inflammation.
- Dr. Eric Berg states that turmeric can contribute to supporting liver health.
- Says turmeric is a natural a med because it helps retain neurotransmitters like serotonin, GABA, and dopamine.
- Recommends turmeric, noting it is an exceptionally rich source of curcumin, which delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
- States that Turmeric may be the most underrated medicinal plant on earth, supporting the brain, liver, and heart, and helping protect healthy cells during chemo or radiation therapy.
Ben Greenfield · Turmeric · warns
- Advises patients to stop turmeric before surgery because it can act as a med or antiplatelet agent.
- Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
- States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
- Recommends root spices like turmeric for use on the AIP diet.
- Advises watching out for black pepper, as it is eliminated in core AIP and many people are surprisingly sensitive to it.
- Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
- Suggests using choice herbs like turmeric when preparing meat to weave in small stressors.
- Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
- Recommends combining black pepper with Triphala and Himalayan pink salt as a powder to brush with, as it is astringent, drives up inflammation and infection in the gums, is refreshing, and prevents plaque.
- Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
- Lists turmeric as one of the ingredients in Organifi Green Juice.
- Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
- Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
- Rubbed the beef with black pepper before searing.
Thomas DeLauer · Turmeric · uses
- Recently started taking turmeric for their joints, specifically for knee issues, as it helps support recovery, especially after a workout.
- Mentions that Dose Daily contains turmeric, which contributes to its positive impact on liver enzyme levels.
- Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
- Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
- Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
- Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
- Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
- States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
- Recommends curcumin, especially when stacked with ginger, noting its anti-inflammatory efficacy and its ability to increase antioxidant defense systems and reduce oxidative stress. He emphasizes taking it with black pepper or piperine, or in a liposomal form, for bioavailability.
- Recommends taking black pepper with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
- Recommends taking piperine with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
- Mentions Turmeric as an ingredient in DOSE that has proven literature behind it for liver health.
- Mentions that Dose Daily, which he recommends for liver support, contains turmeric.
- Recommends curcumin with black pepper for general inflammation, explaining it blocks the primary transcription factor nuclear factor kappa B, shutting down the master regulatory at a genetic level for inflammation genes.
Dr. Mark Hyman · Turmeric · recommends
- Recommends turmeric as an anti-inflammatory powerhouse.
- States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
- Notes that if people have used something like turmeric for several thousand years as a remedy and an anti-inflammatory compound, it can't be wrong.
- Recommends seasoning turmeric with black pepper to help the body absorb more nutrients.
- Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
- States he was using circ turmeric to stimulate the NRF2 pathway and open up detox.
- Recommends curcumin as an anti-inflammatory supplement that can be helpful.
- States that curcumin helps to lower broader inflammatory levels in the body.
- Mentions using turmeric (curcumin) in certain people, especially those with elevated amyloid levels in the blood.
- Recommends Paleovalley's Turmeric Complex, which uses whole food turmeric with over 200 beneficial compounds, plus organic ginger, rosemary, and cloves, to support overall wellness.
- Recommends turmeric as a simple way to support health against stress and inflammation, noting its key compound curcumin supports the body against conditions like cancer, cardiovascular stress, neurogenic diseases, and helps with inflammation, metabolic balance, joint comfort, mood, immune function, and brain health.
- Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
- Notes that black pepper, along with gentle heat, improves the absorption of curcumin in Paleovalley's turmeric complex.
- Recommends turmeric as a simple way to support health, noting its key compound curcumin supports the body against various conditions and helps with inflammation, metabolic balance, joint comfort, and mood. He specifically recommends Paleovalley's Turmeric Complex for its whole food approach and improved absorption.
Dr. Rhonda Patrick · Turmeric · uses
- Likes adding turmeric to bone broth for flavor, warmth, and its anti-inflammatory compounds.
- Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
- Asks if curcumin can slow aging.
- Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
- Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
- Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
- Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
- Took Meriva, a phytosomal curcumin, which has been shown to help with DOMS in some small studies.
- States that curcumin, found in turmeric root, also activates antioxidant defenses.
- Suggests that if someone is an 'immuno-ager,' they might want to take turmeric to help with their immune system.
- Suggests that if someone is an 'immuno-ager,' they might want to take curcumin to help with their immune system.
- Rhonda mentions curcumin as a xenohormetic compound that, in a small dose, is slightly toxic and activates cellular stress response pathways, helping the body deal with stress better.
- Explains that turmeric, specifically curcuminoids, are slightly toxic to the body, which activates phase II detoxifying enzymes and turns on anti-inflammatory genes. She also notes that aromatic turmerone in turmeric can increase neural stem cell proliferation and affect memory and performance.
- Warns that piperine should be avoided by people taking meds because it can extend the half-life of the drug, which could have unknown effects.
Siim Land · Turmeric · recommends
- Mentions that turmeric helps with arthritis and joint pain, with clinical trials showing its effectiveness.
- Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Curcumin as one of 15 supplements backed by human studies.
- Thinks curcumin has some of the strongest evidence and is worth considering.
- Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- States that curcumin, unless contaminated, is not going to raise liver enzymes.
- Did not see a big extension from curcumin in their tests.
- Mentions that it is infeasible to obtain sufficient curcumin from food.
- Places Turmeric or Curcumin in the 'god tier' due to numerous human clinical trials for inflammation, noting that its poor bioavailability means supplements should ideally be liposomal formulations or include piperine (black pepper) to enhance absorption.
- Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
- States that turmeric is known for its anti-inflammatory effects, lowering inflammation markers like CRP in clinical trials.
- Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
- Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
- Places Turmeric (Curcumin) in the 'god tier' due to numerous human clinical trials supporting its anti-inflammatory effects. He advises using liposomal formulations or adding piperine to improve its poor bioavailability.
Dave Asprey · Turmeric · warns
- Warns that turmeric is exceptionally high in oxalate, which can cause issues if consumed in large amounts.
- Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
- Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
- Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
- Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
- Uses turmeric as an example of an unprotected ingredient that, once proven beneficial through studies, allows everyone to take advantage of the knowledge.
- Dave Asprey used to research black pepper extract but changed his mind about its use after a discussion with Christian DPO, who highlighted its downsides.
- Dave Asprey mentions that supplements like curcumin support pain relief and mood.
- Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
- Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
- Dave Asprey mentions that turmeric can stimulate orexin, which keeps you awake, alert, and motivated.
- Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
- Takes an extract of turmeric, a high oxalate food, that provides the good stuff without the bad.
- States that turmeric has anti-parasite qualities and he takes it nearly constantly.
Andrew Huberman · Turmeric · warns
- Recommends avoiding bioavailable curcuminoids like bioavailable turmeric if someone's DHT is already low or if they have somewhat insensitive androgen receptors.
- Discusses curcumin as a supplement for prenatal care and sperm health.
- Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
- Recommends avoiding bioavailable curcuminoids like black pepper extract if someone's DHT is already low or if they have somewhat insensitive androgen receptors.
- Mentions that turmeric is on a list of colorants and could technically move a food into the ultra-processed category, despite being full of curcumin and having possible health benefits.
- Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
- Recommends turmeric to patients for hot flashes, noting some 'okay data' but emphasizes it's not a replacement for estrogen.
- Includes curcumin in his diet because it has been shown to stimulate GLP-1.
- Warns against taking too much turmeric, especially in high doses, due to potential negative effects like limiting dihydrotestosterone production and the risk of lead contamination, advising careful sourcing.
- Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
- Mentions curcumin in the context of 5-alpha reductase.
- States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
- Warns that some people, including himself, are very sensitive to curcumin because it can potently reduce DHT, leading to decreased libido and drive, though these effects reverse quickly after stopping.
- Warns that high doses of turmeric can strongly inhibit DHT, leading to drops in libido for people who are very DHT sensitive.
Bryan Johnson · Turmeric · uses
- Uses turmeric for its antioxidant, anti-inflammatory, and metabolic benefits, noting that black pepper boosts its power.
- Adds black pepper to turmeric because a compound in pepper called piperine boosts the power of turmeric by slowing the breakdown of curcumin in the gut and liver, making its antioxidant, anti-inflammatory, and metabolic benefits last longer.
- Takes one gram of turmeric a day for inflammation, joints, and liver.
- Advises avoiding Curcumin during pregnancy.
Peter Attia · Turmeric · uses
- Peter Attia's brand, AVIA Skincare, incorporates Ayurvedic wisdom, including turmeric and other Eastern botanicals, for anti-inflammatory care.
- Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
- States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
- Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
- Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
- Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
RAL Summary
Members OnlyTier 5 for Joints and Mobility
Human studies support Turmeric (19 of 21 human studies showed an improvement), but there are not yet enough reviews to confirm it (10). 3 of our biohacker panel warn against its main ingredient, so it drops one tier. The final check notes: Tier 5 means good studies show it does not work or most reviews are negative, but the turmeric studies show joint benefit and 7 of the 10 reviews are positive, so too few reviews and the panel warnings support tier 4, not tier 5.
Take 2 servings a day (6 capsules) to match the dose that worked in the studies.
- Not endorsed.
Where the evidence disagrees: 3 of the 29 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Immune system
Combine with: To enhance stress support and calmness, consider combining this Turmeric supplement with adaptogenic herbs like Ashwagandha or Rhodiola Rosea, which are known to help the body manage stress. Magnesium is another excellent addition, as it plays a crucial role in nervous system regulation and can promote relaxation. L-Theanine, an amino acid found in green tea, can also be beneficial for promoting a calm, focused state without drowsiness. These supplements directly target stress pathways and promote relaxation, complementing the general anti-inflammatory benefits of Turmeric.
Possible side effects: Studies found curcumin caused no more side effects than placebo and fewer than meds. No side effects are known from reviews, since none could be read.
Supplement Facts
Turmeric Root Powder 2100 mg · Turmeric Extract 150 mg · Black Pepper Extract 10 mg
| Turmeric Root Powder | 2,100 mg | † |
| Turmeric Extract (standardized to 95% Curcuminoids) | 150 mg | † |
| Black Pepper Extract (standardized to 95% Piperine) | 10 mg | † |
Directions: If needed, you can split the dose for morning and evening. - When to take: recommended to take it with a meal at any time of the day. Taking on an empty stomach may cause discomfort. - Daily use: suitable for long-term daily consumption or as recommended by a healthcare professional.
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Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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