U.S. Enzymes Lumbroxym Review

Lumbroxym™ blends the two systemic enzymes Lumbrokinase and Catalase with Astrazyme®, a proprietary blend that enhances enzyme absorption. Pure Lumbrokinase is difficult to source and a notably expensive proteolytic enzyme that has been shown to support cardiovascular and circulatory health. The product is delivered in 375 FU of Lumbrokinase and 350 U of Catalase in a patented sodium alginate base and protective delayed-release capsules. Lumbrokinase is a fibrinolytic enzyme that helps support healthy circulation and healthy blood pressure levels. The formula also supports longevity and overall immune health. Lumbroxym is described as non-GMO, non-dairy, non-soy, and vegan, with no gluten, fillers, artificial colors, flavors or preservatives. Each bottle contains 62 servings. The serving size is one capsule. The suggested use is to take one capsule with a glass of water on an empty stomach, two hours before or after meals. The page advises consulting a healthcare professional for alternate dosing protocols. The enzyme blend supplies 200 mg of Lumbrokinase 375 FU and Catalase 350 U, plus a proprietary AstraZyme blend of 25 mg. Other ingredients are the capsule (HPMC, gellan gum, water) and sodium alginate. Warnings on the page state that people who take a med or other blood-thinning products, or who are pregnant or lactating, should consult a healthcare professional before taking this product. A second warning advises that anyone pregnant, nursing, or taking meds should consult their healthcare practitioner before use. The page notes that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. U.S. Enzymes states that its products are formulated for healthcare professionals to dispense to their patients. The page lists a patient price of $70.00 and a doctor price of $35.00, with a one-time purchase option at $70.00 or a subscription option at $63.00 with 10 percent savings, deliverable every 20, 40, 60 or 90 days. The company says it offers a money-back guarantee and includes a product information sheet for download.

Product Focus: Joints and MobilityAlso covers:Heart
Tier ⓘ
Tier 4 · Rank 10
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 10 within Tier 4 for Joints and Mobility; 56 of 71 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
57 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
100% of 22
Biohacker Mentions
8 of 10
Cost per month
$34

Study, Trial or Testing Result Summary

Members Only2 human studies · 1 improved
2 human studies1 improved1 no effect814 people studied

This product's main ingredient is an enzyme blend of lumbrokinase and catalase, plus a small hidden blend called AstraZyme with no studies at all. No study given here tested lumbrokinase or catalase for joint health. The two joint studies on file used different enzymes. A pooled reanalysis of six trials in 774 adults with knee arthritis found that an oral blend of protein-digesting enzymes plus a plant flavonoid eased pain and improved function about as well as the painkiller diclofenac, with fewer side effects [1]. A small trial of 40 people with arthritis of the lower spine found that adding bromelain and papain enzymes to a standard painkiller for 6 weeks lowered pain and disability scores [2]. These results cannot be carried over to lumbrokinase, which is a different enzyme with a different purpose. The AstraZyme blend is hidden in a proprietary mix at 25 milligrams, and nothing is known about what it does for joints. So, for joint health, there is no direct human evidence for this product's ingredients either way. Animal and cell studies are never counted.

See all 2 studies →Hide the studies

Review Totals and Summary

Members Only22 reviews · 100% positive
22 reviews · Amazon 12 · Professional Supplement Center 2 · NHC 2 · Pureformulas 2 · Blueskyvitamin 2 · Cincinnatihealthinstitute 2
100% positive0% neutral0% negative

Across the two stores there are 16 ratings in total, and the themes below come from the written reviews that could be read on their pages, which amount to two reviews that appear identically on both pages: one from Elizabeth H. and one from Tara D. Because so few written reviews were readable, everything here reflects two individual experiences rather than a broad consensus. No reviews of other product forms appeared in the summaries, so nothing had to be left out on that count. What buyers praise: Both reviewers are verified buyers and both report a positive effect in their own words. Elizabeth H. gave 5 stars about three years ago and says that, in her experience so far, Lumbroxym has been helpful. She marked that she recommends it. Tara D. gave 4 stars about two years ago. She says she was told the product would help with the effects of Lyme, and her one concrete benefit is that it seems to help her heart avoid constant tachycardia. That is the only measurable-sounding symptom mentioned anywhere in the reviews, and it is a perceived benefit rather than a measured result. The pages show a 100 percent would-recommend figure, which matches the recommendation given. Who it seems to suit: Both reviewers use Lumbroxym for Lyme-related symptoms, not for the cardiovascular claims printed on the listing. Elizabeth says she has Lyme along with Babesia and Bartonella, and that her physician prescribed Lumbroxym as a biofilm buster alongside Disulfiram and Methylene Blue. Tara was told it would help with Lyme effects. Both frame the product as something taken under the guidance of a healthcare practitioner as part of a treatment plan for a chronic condition. Complaints: None. Neither review reports side effects, dissatisfaction, or any problem. The 4 star rating from Tara comes with no stated reason for withholding the fifth star. Taste, form, and value: Nothing can be drawn on these themes. Neither review mentions taste, capsule size, swallowing, delivery of the enzymes, price, value, or shipping. Neither describes the capsules or the dosing routine in any detail, and neither gives dosage information beyond what the product page already states. The reviews also do not say how long either person took the product or whether the results lasted. How to read this: The comments are anecdotal patient reports tied to Lyme-related protocols. They do not address the cardiovascular or longevity claims made elsewhere on the pages, and they offer no data on those claims. With only two written reviews, the star average and the 100 percent recommendation figure are a very small sample. Anyone considering the capsules for Lyme should treat these accounts as individual experiences and discuss use with their practitioner.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Only one member of the panel spoke about the enzyme blend, which is the main ingredient in this product, so there is no group view to report. That panelist recommends it. They suggest taking a blend of different enzymes as nutritional help when eating certain foods. They say it matters most for people who eat mostly cooked, canned or pasteurized food. No one gave a dose or a preferred form, no pairings were mentioned, and no one raised a caution or said they stopped.

See all 1 biohackers →Hide the biohackers
  • Dr. Eric Berg · Enzyme Blend · recommends
    • 29 Apr 2020 · recommends · YouTube ↗
      Recommends taking a blend of different enzymes as nutritional assistance when eating certain foods, especially if consuming mostly cooked, canned, or pasteurized food.

RAL Summary

Members OnlyTier 4 for Joints and Mobility

The ineffective grade rests on studies of bromelain, papain and other protein-digesting enzyme blends, not the lumbrokinase and catalase in this product, and both of those studies actually reported improvement rather than no effect. So it is graded Tier 4, as the studies disagree.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 1 of the 2 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Cardiovascular system

Combine with: For circulatory support, Lumbroxym is often paired with nattokinase, omega-3 fish oil, and magnesium. Taking it with CoQ10 or ubiquinol and with vitamin K2 (MK-7) may add cardiovascular and vascular support. For the stated aging and DNA repair goal, add targeted ingredients such as NMN or nicotinamide riboside (NAD+ precursors), resveratrol or pterostilbene, quercetin, alpha-lipoic acid, and astaxanthin. Because lumbrokinase has blood-thinning effects, anyone taking meds, antiplatelet drugs, or fish oil in high doses, or facing surgery, should consult a healthcare provider before combining it with other agents.

Possible side effects: No major side effects reported; the studies of other enzyme blends found fewer side effects than a common painkiller, and the reviews mention none.

Supplement Facts

Enzyme Blend 200 mg · Proprietary AstraZyme Blend 25 mg
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 62
Amount Per Serving% Daily Value
Enzyme Blend200 mg†
Proprietary AstraZyme Blend25 mg†
† Daily Value not established.

Other ingredients: Hydroxypropyl Methylcellulose, Gellan Gum, Water, Sodium Alginate.

Directions: Suggested use: Take one (1) capsule on an empty stomach two (2) hours before or after a meal. Use this product with Digestxym or Digestxym+ for more effective results.

Barcode (UPC) 819242002785 · Label source: NIH label database · Report a label change

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Graded November 8, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.