Vitamin World Timed Release Pantothenic Acid 500 mg Review
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Study, Trial or Testing Result Summary
Members Only1 human studies · 1 improved
This study gave pantothenic acid by drip, not by mouth.
Only one human study has looked at this ingredient for bowel regularity, and it did not test the form or use of this product. In a small, preliminary controlled trial, 60 people recovering from bone and joint surgery were given either dexpanthenol, a form of pantothenic acid, through a vein, or salt water on the second and third days after surgery. Higher doses shortened the time until the first bowel movement compared with salt water [1]. The study did not report what share of people improved [1]. It did not test pantothenic acid swallowed as a tablet, as in this product, and it did not look at long-term relief of everyday occasional constipation. It only looked at bowels slowing down right after surgery [1]. This product gives 500 milligrams of pantothenic acid per serving, but no study tested this oral dose for regularity. Larger studies of oral supplements in people with ongoing occasional constipation are needed before any firm conclusion can be drawn. Customer ratings are strongly positive, but no written reviews could be read, so it is not known whether buyers used it for regularity. Animal and cell studies are never counted.
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- In 60 orthopedic surgery patients given intravenous dexpanthenol (a pantothenic acid derivative) on the second and third days after surgery, the time to first bowel movement got shorter as the dose went up compared with saline, though the study was small and preliminary.A pilot study of the effect of pantothenic acid in the treatment of post-operative ileus: results from an orthopedic sur…
Review Totals and Summary
Members Only7,600 reviews · 93% positive
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Four of the ten panelists spoke about pantothenic acid, also called vitamin B5, and three of those four recommend it. They take it mainly for adrenal gland support, for fat metabolism, and to fight fatigue, with one also mentioning it for repairing the gut lining and for clear skin. Preferred sources include a B complex or vitamin B5 on its own, plus a cream applied to the skin, and one panelist used a product with 5000 percent of the daily need. The fourth panelist warns that high doses can dry the skin and says deficiency is rare in healthy people, so supplements are generally unnecessary, and another cautions against synthetic forms or massive single doses because they can create shortfalls in other nutrients like biotin. No one reported stopping it, and no panelist gave a dose close to the 500 milligrams in this product.
See all 4 biohackers →Hide the biohackers
Dr. Mark Hyman · Pantothenic Acid · recommends
- Mentions pantothenic acids as one of the things that can be used to repair mucosal membranes as part of the 'repair' step in the 4R program.
Ben Greenfield · Pantothenic Acid · recommends
- Recommends Vitamin B5 (pantothenic acid) as a critical nutrient for adrenal gland support, suggesting it can be obtained from a B complex or Vitamin B5 itself.
- Ben Greenfield uses Life Shots which contain 5000% of daily Pantothenic Acid needs.
- Recommends pantothenic acid cream, noting that many such lotions are rich in vitamin A and can be applied directly to the skin to help with various skin issues.
- Recommends Vitamin B5 (pantothenic acid) as a critical nutrient for supplying the adrenal gland, suggesting it can be obtained from a B complex or Vitamin B5 itself.
Thomas DeLauer · Pantothenic Acid · warns
- Explains that Vitamin B5, or pantothenic acid, is tremendous for fat metabolism and weight loss, but warns that taking it in high doses can cause skin dryness.
- Discusses the importance of pantothenic acid (vitamin B5) for fat metabolism, as it is crucial for forming coenzyme A, which is needed to break down fats.
- Notes that Vitamin B5 (Pantothenic acid) is important for the metabolism of the gut microbiome, but spontaneous deficiency is rare in healthy individuals, making supplementation generally unnecessary.
- Notes that cod provides vitamin B5 (pantothenic acid), which is needed to create adrenaline and cortisol, supporting adrenal glands and upregulating adrenaline for fat loss by activating fat-burning processes.
Dr. Eric Berg · Pantothenic Acid · recommends
- Dr. Berg recommends taking B5 (pantothenic acid) if experiencing fatigue, as it acts as a helper for fat-burning enzymes.
- Dr. Berg states that vitamin B5 (pantothenic acid) gives clear skin, but warns against taking it synthetically or in massive individual dosages, as it can create deficiencies in other things like biotin.
- Recommends taking vitamin B5 (pantothenic acid) to combat fatigue and lethargy when transitioning to a ketosis diet, as it supports fat metabolism and adrenal glands.
RAL Summary
Members OnlyTier 4 for Regularity: Long-Term Relief
The tier 2 grade rests on a single small trial of dexpanthenol given into a vein after surgery, which did not test pantothenic acid taken by mouth or long-term relief of everyday constipation. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported.
Supplement Facts
Pantothenic Acid 500 mg
Other ingredients: Vegetable Cellulose, Dicalcium Phosphate, Stearic Acid, Contains <2% of:.
Directions: Directions: For adults, take one (1) caplet up to two times daily, preferably with meals.
Barcode (UPC) 074312760600 · Label source: NIH label database · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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