Wild & Organic Milk Thistle Drops Review
Wild & Organic Milk Thistle Drops offer a premium, liquid dietary supplement meticulously crafted to support liver health and overall detoxification processes. This potent tincture harnesses the power of Organic Milk Thistle Extract (Silybum marianum), specifically derived from the plant's seeds, which are rich in a complex of active compounds known as silymarin. Silymarin is the primary bioactive component responsible for milk thistle's renowned therapeutic properties. The formulation of these drops distinguishes itself by being entirely alcohol-free, utilizing certified organic vegetable glycerin and purified water as its base. This thoughtful choice ensures a gentle yet effective delivery system, making it suitable for individuals who prefer to avoid alcohol in their supplements. The vegetable glycerin also imparts a natural sweetness, eliminating the need for added sugars and making the drops a pleasant addition to water, juice, coffee, or smoothies. At the core of milk thistle's efficacy lies silymarin's multifaceted mechanism of action, primarily centered on its powerful antioxidant and anti-inflammatory capabilities. The liver, being the body's primary detoxification organ, is constantly exposed to environmental toxins, pollutants, and metabolic byproducts that generate harmful free radicals. Silymarin acts as a potent antioxidant, effectively scavenging these free radicals and neutralizing their damaging effects, thereby reducing oxidative stress on liver cells. Beyond its antioxidant prowess, silymarin exhibits significant anti-inflammatory properties. Chronic inflammation is a key factor in the progression of various liver diseases, potentially leading to fibrosis and scarring. By modulating inflammatory pathways and inhibiting the release of pro-inflammatory mediators, milk thistle helps to mitigate inflammation within liver tissue, contributing to the maintenance of the liver's structural integrity and functional capacity. Furthermore, silymarin is believed to exert hepatoprotective effects by altering the liver cell membrane, making it more resistant to the entry of certain toxins. It also supports the liver's natural regenerative processes by stimulating protein synthesis and promoting the formation of new, healthy liver cells. This comprehensive action helps the liver in its natural cleanse and detox pathways, supporting the elimination of harmful substances from the body. The liquid tincture format of Wild & Organic Milk Thistle Drops is designed for optimal absorption, boasting a reported 98% absorption rate within minutes, which is often cited as superior to traditional pills or capsules. Each serving provides 600 mg of organic milk thistle extract, with a recommended dosage of one full dropper bulb (approximately 0.7 ml) taken three times daily. This vegan, non-GMO, and additive-free supplement is a convenient and effective way to incorporate liver support into a daily wellness routine, with bottles offering a 28-day (2 fl. oz.) or 56-day (4 fl. oz.) supply when used as directed.
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Study, Trial or Testing Result Summary
Members Only59 human studies · 33 improved
This product gives 600 milligrams of milk thistle extract a day, which is at or above the amounts used in the studies below. A 2025 review of 55 trials with 3545 people with liver injury found that silymarin, the active part of milk thistle, lowered two main liver enzymes, though it helped less in liver damage caused by drugs or alcohol [1]. A 2024 review of 26 trials with 2375 people with fatty liver found lower liver enzymes and blood fats, and less fat in the liver on biopsy [2]. Another pooled analysis linked it to better liver scarring scores than placebo [3], and a review of plant compounds found it lowered liver fat and liver stiffness [4]. In 170 people with cirrhosis, 420 milligrams a day for about 41 months raised four year survival to 58 percent, compared with 39 percent on placebo [5]. In 83 adults with fatty liver, about 103 milligrams a day for 24 weeks reduced liver stiffness, but liver fat on scans did not change [6]. Not every result was positive, and some trials in people with alcohol related or more serious fatty liver disease found no clear benefit on their main measures. Animal and cell studies are never counted.
See all 59 studies →Hide the studies
- Across 55 randomized trials with 3545 people with liver injury, silymarin lowered the liver enzymes AST and ALT but not ALP, with less benefit in people with drug-induced or alcohol-related liver disease.Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on ra…
- Across 26 randomized trials with 2375 people with fatty liver disease, silymarin lowered liver enzymes, cholesterol and fat markers and improved fat build-up in the liver on biopsy.Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis.
- In a review of trials of eight plant polyphenols in 2173 people with fatty liver disease, silymarin lowered liver enzymes, liver fat and liver stiffness.Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A syste…
- In a pooled analysis of placebo-controlled trials in adults with fatty liver disease, silymarin was linked to higher odds of improved liver scarring stage compared with placebo.Comparative Efficacy of Drug Interventions on NAFLD Over 24 Weeks: A Traditional and Network Meta-Analysis of Randomized…
- In a review of 29 trials with 1840 people with fatty liver disease, most silymarin studies showed lower liver enzymes and blood fats, but no change in inflammation markers.Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review.
- A review of trials in people with chronic viral hepatitis found silymarin likely lowered liver enzymes but did not change viral load or liver tissue damage.Silymarin treatment of viral hepatitis: a systematic review.
- A review of clinical data on supplements for fatty liver disease concluded silymarin, if well dosed and taken for medium to long periods with lifestyle changes, could have positive effects.Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence.
- A review of 40 meta-analyses in adults found silymarin had positive effects on certain liver enzymes, though evidence quality was generally weak.Natural products and dietary interventions on liver enzymes: an umbrella review and evidence map.
- In 370 tuberculosis patients, milk thistle capsules did not prevent anti-tuberculosis drug liver injury compared with vitamin C, and a stricter definition of liver injury was more common in the milk thistle group.Preventive use of a hepatoprotectant against anti-tuberculosis drug-induced liver injury: A randomized controlled trial.
- In 222 people with Alzheimer's disease taking tacrine, 420 mg a day of silymarin for 12 weeks did not prevent the rise in the liver enzyme ALAT compared with placebo, though it reduced stomach and cholinergic side effects.Aminotransferase levels and silymarin in de novo tacrine-treated patients with Alzheimer's disease.
- In 170 people with cirrhosis of the liver, 420 mg a day of silymarin for about 41 months on average raised 4-year survival to 58% compared with 39% on placebo, with no side effects seen.Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver.
- In 150 people with fatty liver disease split across five groups, 140 mg a day of silymarin for 3 months significantly lowered liver enzymes (ALT and AST), while the lifestyle-plus-placebo group did not see a significant drop.Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial.
- In 150 people with type 2 diabetes, a seven-herb combination including milk thistle taken for 3 months improved blood sugar, and no notable liver side effects were seen, but liver benefit was not shown.Efficacy and Safety of a Traditional Herbal Combination in Patients with Type II Diabetes Mellitus: A Randomized Control…
- In 146 people at risk of fatty liver disease, Heptex capsules containing 100 mg milk thistle extract for 36 weeks lowered liver enzymes within groups but did not beat placebo, and were safe and well tolerated.The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in pat…
- In 116 people with alcoholic hepatitis, 420 mg of silymarin daily for three months did not beat placebo; both groups improved similarly.[Treatment of alcoholic hepatitis with silymarin. A double-blind comparative study in 116 patients].
- In 113 people with fatty liver disease taking a mixture of natural ingredients including silymarin for 3 months, liver enzymes and other markers did not improve more than in the control group, though the mixture was well tolerated.Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver dise…
- In 106 people with liver disease mostly caused by alcohol, silymarin for 4 weeks lowered liver enzymes more than placebo, normalized liver function tests more often, and normalized liver tissue changes more often.Effect of silymarin on chemical, functional, and morphological alterations of the liver. A double-blind controlled study…
- In 105 adults with acute hepatitis in Egypt, 140 mg of silymarin three times daily for four weeks led to faster resolution of dark urine, jaundice and yellowing of the eyes than placebo, with no side effects, though liver enzymes did not differ significantly.A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute …
- In 99 adults with fatty liver inflammation (NASH), silymarin at 700 mg three times daily for 48 weeks did not significantly improve the overall disease activity score compared with placebo, but it led to more people with reduced liver scarring and lower liver stiffness than placebo.A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis.
- In 97 people with thalassemia major taking desferrioxamine, adding silymarin from milk thistle for 9 months improved liver function tests more than placebo did, and also lowered iron overload markers.A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients …
- In 83 adults with fatty liver disease, 103.2 mg of silymarin daily for 24 weeks significantly reduced liver stiffness compared with placebo, with no significant change in fat content on scan.Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated ste…
- In a crossover placebo-controlled trial of 82 people with beta-thalassemia major, 140 mg of silymarin three times daily for 12 weeks reduced liver iron, but changes in liver function were not statistically significant.Iron-chelating effect of silymarin in patients with β-thalassemia major: A crossover randomised control trial.
- In 82 children with leukemia receiving chemotherapy, silymarin for eight weeks lowered liver enzymes ALT and AST, though a Persian fruit infusion lowered ALT more; there was no placebo group.Efficacy of a traditional persian fruit infusion (Naqu Fawakeh) versus silymarin in reducing chemotherapy-induced hepato…
- In 78 adults with fatty liver inflammation (NASH), silymarin at 700 mg three times daily for 48 weeks did not improve the disease activity score more than placebo, with 4 of 27 people on this dose reaching the primary target versus 3 of 25 on placebo.Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial.
- In a placebo-controlled trial of 74 acne patients taking a med, 140 mg of silymarin daily for 30 days kept liver enzymes (AST and ALT) from rising compared with placebo.Read the study on PubMed (31997509) →
- In 72 people with alcoholic liver disease followed for about 15 months, 280 mg daily of silymarin did not change how the disease progressed or the risk of death compared with placebo.[Controlled study of the effect of silymarin on alcoholic liver disease].
- In 68 overweight adults with fatty liver disease, a supplement containing silymarin plus a Mediterranean diet for three months improved liver steatosis more than the diet alone, with a 9-point drop in the liver steatosis index versus 6 points in the diet-only group.The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of…
- In 62 people with decompensated hepatitis C cirrhosis, a high dose of 1,050 mg silymarin daily for 12 weeks improved liver enzymes, albumin, bilirubin and clotting ratio, while the 420 mg dose did not.High Dose of Silymarin in Patients with Decompensated Liver Disease: A Randomized Controlled Trial.
- In 60 people with compensated alcoholic cirrhosis, one month of silymarin (dose not stated) normalized elevated liver enzymes and bilirubin and reduced gamma-glutamyl transferase, while the placebo group showed no such changes.Immunomodulatory and hepatoprotective effects of in vivo treatment with free radical scavengers.
- In 55 tuberculosis patients, silymarin taken for four weeks reduced the risk of antituberculosis drug-induced liver injury (1 of 27 vs 9 of 28 on placebo), and the silymarin group kept more of its antioxidant enzyme superoxide dismutase.A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver inju…
- In 50 children with leukemia and liver toxicity, milk thistle for 28 days did not change liver tests at day 28 versus placebo, though AST was significantly lower by day 56.A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acu…
- In 50 people with type 2 diabetes and high cholesterol, a polyherbal powder containing 500 mg milk thistle seed twice daily for 12 weeks did not change liver enzymes ALT or AST, with no harm to the liver.A Randomized Controlled Trial of a Herbal Compound for Improving Metabolic Parameters in Diabetic Patients with Uncontro…
- In 50 hospitalized people with COVID-19 taking nano-silymarin three times daily for 2 weeks, alanine aminotransferase fell more than with placebo, but symptoms and hospital stay did not differ.Evaluation of the efficacy of oral nano-silymarin formulation in hospitalized patients with COVID-19: A double-blind pla…
- In a trial of 260 people with fatty liver disease testing a traditional Chinese herbal granule, a silibinin arm of 50 people significantly lowered ALT only, while the herbal granule had broader effects; the study did not compare silibinin with placebo.Danshao Shugan Granule therapy for non-alcoholic fatty liver disease.
- In 48 people with multiple sclerosis taking fingolimod, silymarin for six months lowered liver enzymes ALT and AST and a marker of oxidative stress (malondialdehyde) and raised antioxidant capacity compared with placebo.Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remi…
- In 34 people with chronic hepatitis C, 160 mg of milk thistle extract three times a week for 4 weeks lowered liver enzyme levels compared with no treatment, with no side effects reported, but did not reduce the virus level.Does Silybum marianum play a role in the treatment of chronic hepatitis C?
- In 32 people with chronic hepatitis C, silymarin up to 2.1 grams a day for seven days was safe and well tolerated, but it did not meaningfully lower liver enzymes or hepatitis C virus levels compared with placebo.Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C.
- In 30 breast cancer patients given chemotherapy, 140 mg of silymarin three times daily for one month reduced liver involvement on ultrasound within the group, but the difference from placebo was not significant and FibroScan and liver tests did not differ.Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients: A r…
- In 20 people with chronic active hepatitis, 240 mg of milk thistle silybin taken twice daily for 7 days significantly lowered liver enzymes and bilirubin in the treated group, though the placebo comparison is not reported as significant.A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatiti…
- In a placebo-controlled trial of people with multiple sclerosis taking interferon beta, adding silymarin lowered liver enzyme levels and reduced inflammatory signals compared with placebo.Significant immunomodulatory and hepatoprotective impacts of Silymarin in MS patients: A double-blind placebo-controlled…
- In a randomized double-blind study of liver cirrhosis, people with alcoholic cirrhosis given silymarin had a significantly higher survival rate than those given placebo.[The influence of therapy with silymarin on the survival rate of patients with liver cirrhosis (author's transl)].
- In 60 people with alcohol-related liver disease, adding 400 mg of silymarin daily to ursodeoxycholic acid lowered liver enzymes further than ursodeoxycholic acid alone over about six months.[Use of ursodeoxycholic acid combined with silymarin in the treatment of chronic ethyl-toxic hepatopathy].
- In 60 people with alcoholic or nonalcoholic steatohepatitis, a combination of essential phospholipids and silymarin shortened symptom duration and lowered transaminases more than the comparison products Essentiale and Carsil.[Study of clinical efficiency of essential phospholipids and silymarin combination in nonalcoholic and alcoholic steatoh…
- In 60 insulin-treated diabetic people with alcohol-related cirrhosis, taking 600 mg of silymarin daily for 12 months along with standard therapy lowered blood sugar, insulin needs and a marker of cell membrane damage compared with standard therapy alone.Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insuli…
- In 55 people with occupational toxic liver disease, 420 mg of silymarin daily produced slight changes in some liver function tests, while the placebo group showed no significant change; the effect seemed greater when exposure was shorter.[Toxic occupational liver diseases. Therapeutic effects of silymarin].
- In 40 people with alcoholic cirrhosis, one month of silymarin (dose not stated) normalized elevated liver enzymes and bilirubin and reduced gamma-glutamyl transferase, while the placebo group showed no such changes.Hepatoprotective and immunological effects of antioxidant drugs.
- In 40 people with alcoholic cirrhosis, one month of silymarin (dose not stated) normalized elevated liver enzymes and bilirubin and reduced gamma-glutamyl transferase, while the placebo group showed no such changes.Hepatoprotective and immunomodulatory effects of antioxidant therapy.
- In 30 people with hepatitis C, 400 mg of silymarin daily added to sofosbuvir and ribavirin for eight weeks was reported to lower liver enzymes and improve antioxidant markers, though the liver enzyme changes were not statistically significant.Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniat…
- In a small controlled study of gallstone and gallbladder-removed patients, 420 mg of silymarin daily for 30 days reduced cholesterol concentration in bile.Effect of Silibinin on biliary lipid composition. Experimental and clinical study.
- In a six-month double-blind placebo-controlled trial in people with chronic alcohol-related liver disease, 420 mg of silymarin daily raised antioxidant defenses and lowered a marker of fat damage compared with placebo.[Effect of silimarin (Legalon) therapy on the antioxidant defense mechanism and lipid peroxidation in alcoholic liver di…
- In 190 people with fatty liver disease, a combination of silymarin, vitamin E and essential phospholipids for six months was followed by lower liver enzymes, blood fats, blood sugar and liver fibrosis scores, with no side effects, though there was no placebo group.Therapeutic Efficacy of Silymarin, Vitamin E, and Essential Phospholipid Combination Therapy on Hepatic Steatosis, Fibro…
- In 30 people with advanced type 2 diabetes taking a six-herb formula that includes milk thistle twice daily for 40 days, liver and kidney blood tests did not change significantly, though blood sugar, HbA1c and some blood fats improved.Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with ad…
- In a dose-finding study of 3 people with advanced liver cancer and poor liver function, taking 2 grams a day of milk thistle extract was followed by worsening liver tests in all 3, and all 3 died within 23 to 69 days, possibly from liver failure.A phase I dose-finding study of silybin phosphatidylcholine (milk thistle) in patients with advanced hepatocellular carc…
- In people with fatty liver inflammation (NASH) given a silybin supplement for 12 months without a control group, liver scores improved significantly only in the milder group, and blood fat damage markers fell in that group.Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a p…
- In 1145 people with chronic hepatitis C, silymarin users had similar liver enzyme and virus levels to non-users but reported fewer symptoms and somewhat better quality of life, though the use was self-chosen and not controlled.Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial…
- In a retrospective review of 602 people across India, about 11 months of Liverubin silymarin (140 mg three times daily) was followed by large average drops in bilirubin and liver enzymes, with no significant treatment-related side effects.Effect of Liverubin™ on hepatic biochemical profile in patients of alcoholic liver disease: a retrospective study.
- In 13 prostate cancer patients taking high-dose silybin-phytosome (2.5 to 20 g daily, with 13 g daily recommended), the most common side effect was raised bilirubin, found in 9 of 13 patients, and asymptomatic liver toxicity was the most common adverse event.A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.
- This paper describes a statistical method for comparing liver biopsy results from a controlled trial of silymarin in chronic hepatitis, but the abstract does not report the outcome of that trial.Analysis of a certain type of 2 x 3 tables, exemplified by biopsy findings in a controlled clinical trial.
- In rats, silymarin reduced liver fat through gut bacteria that produce vitamin B12, and in people, changes in blood vitamin B12 tracked inversely with blood triglycerides.Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin.
Review Totals and Summary
Members Only1,174 reviews · 100% positive
Customers generally have a very positive view of Wild & Organic Milk Thistle Drops, which holds about 1174 ratings across various stores, with all star-rated reviews giving it 4 or 5 stars. This liquid supplement is frequently praised for its quality and perceived benefits. **What buyers say it did for them** Many users report positive effects, particularly concerning liver health. Some note that their "labs are now normal" after using the product, while others feel their "liver thanks you." The drops are also popular for pets, with owners stating that their "doggie is doing so much better" and that it "Works for my dogs," even improving the quality of life for an older parrot with existing liver concerns. Beyond liver support, some customers experienced improved digestion, with one noting it "helps with upset stomach," and others felt it "gives more energy during the day." **What they complain about** While feedback is overwhelmingly positive, a few points of caution or uncertainty emerge. Some users are unsure about the product's effectiveness, stating, "I can not attest to its effectiveness" or "I’m not sure if it is actually helping." A specific warning advises caution for those with compromised livers, suggesting that "If your liver is compromised you could get nauseous" if the dosage is increased too quickly. **Taste, smell, and form** The liquid form of Wild & Organic Milk Thistle Drops is generally well-received. Many describe the taste as pleasant, with comments like "tastes fine," "Awesome, taste great," and even "It's delicious." Its liquid nature makes it "easier to swallow" and "easy to swallow by adding it to water," with some users squirting it directly under their tongue. A significant advantage for many is that it is "made without alcohol," making it suitable for children and animals. Customers also appreciate the product's packaging, noting it arrived in "excellent condition, with extra padding." **Value for money** While specific comments on value are limited, one review mentioned a "good offer at the time." The consistently high ratings and repeat purchases across a large number of customers suggest that buyers generally perceive the product as offering good value for its price. **Who it seems to suit and who it did not** This product appears to be well-suited for individuals seeking liver support, those with digestive issues, and pet owners looking for a natural supplement for their animals' liver and kidney health. Its alcohol-free formulation makes it a preferred choice for families and pet owners. It is also ideal for those who prefer liquid supplements over pills. However, individuals with compromised livers should start with a low dose and increase slowly to avoid potential nausea. Some users may also find that the effects are subtle, leading to uncertainty about its direct impact.
Biohacker Summary
Members Only5 of 10 recommend it
Six of the ten panelists spoke about milk thistle, the main ingredient, and most of them recommend it, mainly for liver support and detox. Some take it around alcohol, accidental poisoning, or before hot-cold contrast therapy, and others suggest it for skin problems, allergy symptoms, or an enlarged prostate. Doses came up three times: 200 to 400 mg of silymarin at 80 percent, 70 to 140 mg of silymarin taken 30 to 60 minutes before contrast therapy, and 200 mg a day for allergy symptoms. One panelist pairs it with NAC, vitamin C, and water in case of poisoning. One panelist stopped because it did nothing for him, and he warned that it can raise liver enzymes in some people and suggested ground flaxseed as a better option.
See all 6 biohackers →Hide the biohackers
Thomas DeLauer · Milk Thistle · neutral
- Notes that Dose Daily contains organic milk thistle, highlighting its significant data supporting liver health benefits.
- Says he feels really good when he takes milk thistle, usually for about a week, and notes it is effective.
- Recommends Milk thistle, specifically 200-400mg of silymarin at 80%, for decent reductions in ALT and AST and higher antioxidant enzyme activity.
- Recommends milk thistle for liver health, explaining that silymarin lowers MDA and raises antioxidant enzymes.
- Mentions Milk Thistle as an ingredient in DOSE that has proven literature behind it for liver health.
- Recommends milk thistle for the liver, citing a study where it reduced a marker of liver stress and increased antioxidant defense enzymes.
- Mentions that Dose Daily, which he recommends for liver support, contains organic milk thistle, noting that milk thistle has a lot of data behind it for promoting daily liver function.
- Recommends milk thistle for liver health, stating it competitively inhibits toxin binding sites on liver cells, decreasing the liver's load, and upregulates glutathione, reducing elevated liver enzymes even in patients with fatty liver disease, but advises cycling it.
- Recommends milk thistle to help the liver clear things out of the system, including excess cortisol.
- States that simple things like milk thistle supplementation are quite good for the liver, recommending small amounts.
Dr. Eric Berg · Milk Thistle · recommends
- Recommends taking milk thistle for alcohol and for certain medications.
- Suggests that small changes like milk thistle can help with deep rest.
- Dr. Eric Berg recommends taking milk thistle to support the liver and help improve skin problems.
- Describes milk thistle as an antidote for liver protection against poisons and a powerful antioxidant for nerves and the brain, helping to decrease toxic plaque associated with dementia.
- Recommends Milk Thistle as a natural inhibitor of the five alpha reductase enzyme, which helps reduce DHT and has very few side effects for an enlarged prostate.
- Recommends milk thistle as an herb that can increase the contraction of the gallbladder.
- Recommends milk thistle as the best antidote for snake bites.
- Recommends milk thistle before bed if night waking between 1 a.m. and 3 a.m. signifies a liver problem.
- States that milk thistle is great for detoxification.
- Recommends milk thistle for anything poisonous to the liver.
Dr. Mark Hyman · Milk Thistle · recommends
- Recommends milk thistle for detoxification support.
- Recommends taking the herb milk thistle before and after drinking, as it is great for helping liver detoxification.
- Recommends milk thistle for detoxification, lowering iron, and reducing liver inflammation.
- Dr. Hyman recommends Milk Thistle.
- States that milk thistle is great for detoxing.
- Recommends milk thistle as an incredible herb that helps with liver disease and boosting glutathione.
- Recommends taking milk thistle to boost glutathione and support detoxification.
- Recommends milk thistle as an herb that can be used to help boost the body's detox pathways.
- Recommends milk thistle as a great herb to help heal the liver.
- Recommends milk thistle as an incredible herb that helps with liver disease and boosting glutathione.
Ben Greenfield · Milk Thistle · recommends
- Recommends taking a milk thistle supplement standardized to 70-140mg silymarin 30-60 minutes before hot-cold contrast therapy.
- Mentions milk thistle extract as something that can help accelerate the liver's detox pathways to get rid of acetaldehyde more quickly.
- Includes milk thistle in the senolytic formula because it mechanistically works on a subfamily of tyrosine kinases, which are important in shifting the balance towards apoptosis, similar to how a med works, and it is also a healthy liver tonic herb.
- States that if they have to use chemicals like heartworm prevention or flea and tick treatments on their dog, they will use milk thistle or a liver detox to support detoxification.
- Recommends taking milk thistle along with NAC, vitamin C, and water in case of accidental poisoning, stating that this combination could save a life from almost any kind of poison.
- Recommends milk thistle extract, specifically silymarin, for its ability to protect and promote the growth of liver cells, fight oxidation, block toxins from entering cell membranes, and enhance detoxification by preventing glutathione depletion.
- Uses Kion's MetaClear SGS meal replacement powder, which is formulated with multivitamins, minerals, and detoxification cofactors to support liver and gut health, and he blends it with ice, coconut milk or bone broth, sea salt, and sometimes olive oil.
- Uses milk thistle as part of his herbal anti-inflammatories for soreness.
- Mentions Milk Thistle as a nutrient that can help increase the body's own glutathione.
- Recommends Milk Thistle to enhance GST function, which is important for glutathione recycling, especially for individuals with genetic deletions in GST genes.
Siim Land · Milk Thistle · stopped
- Tried milk thistle for improving liver health based on research, but it didn't do anything for him.
- Used to take milk thistle in the past but no longer does, as he has already tested most supplements.
- Mentions milk thistle as something that helps support detox.
- Notes that milk thistle, a famous supplement for fatty liver, can actually raise liver enzymes in some people and does not lower them universally, and that its active ingredient, pselarin, is also found in ground flaxseed, which is a better alternative.
- Siim Land, Inca, started using milk thistle around the same time her liver values improved, noting that it works through a similar pathway as NAC.
- Includes milk thistle among supplements that can boost autophagy levels.
- Due to a liver problem and high cholesterol, Siim Land takes "quite a bit" of milk thistle.
- Suggests taking milk thistle to bind to toxins and prevent detox symptoms.
- Recommends milk thistle as an example of an easy-to-find binder for detox symptoms.
Dave Asprey · Milk Thistle · neutral
- Dave Asprey mentions Milk thistle as a natural remedy for allergy symptoms.
- Suggests trying milk thistle seed for allergy symptoms, highlighting its anti-inflammatory properties that can block histamine release and support liver detoxing abilities. They recommend starting with 200 mg per day when experiencing symptoms.
- Recommends milk thistle as an herb that can help clear liver congestion and support its smooth functioning.
RAL Summary
Members OnlyTier 4 for Liver Health
Placed in this tier because strong reviews of many trials show milk thistle lowers liver enzymes and liver fat [1][2], yet only 45% of buyers who mention liver health say it helped them.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 13 of the 59 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Liver, Digestive system
Combine with: To enhance liver health and detoxification, consider combining Milk Thistle with N-Acetyl Cysteine (NAC), which is a precursor to glutathione, a powerful antioxidant crucial for liver function. Alpha-Lipoic Acid can also be beneficial as it recycles other antioxidants and supports liver detoxification pathways. Additionally, B-complex vitamins are essential cofactors for many liver enzymes involved in detoxification. Dandelion root and Artichoke extract are other herbal allies that can further support bile flow and overall liver function.
Possible side effects: The long cirrhosis trial reported no side effects. One buyer warned that people with a damaged liver may feel sick to the stomach if they raise the dose too quickly.
Supplement Facts
Organic Milk Thistle Extract 600 mg
| Organic Milk Thistle Extract (Silybum marianum) (seed) | 600 mg | † |
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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