Ashwagandha 450 mg Now Review
NOW Supplements Ashwagandha (Withania somnifera) 450 mg, Standardized Extract, comes as 90 vegetarian capsules. The page describes Ashwagandha as an Ayurvedic adaptogen used as a general tonic, helping the body adapt to temporary normal stress. Each NOW Ashwagandha capsule is a standardized extract providing 450 mg per serving. The suggested use shown on the page is to take 1 capsule 2 to 3 times daily. The listing also highlights free radical scavenging and immune system support, with the page noting that preliminary data suggest Ashwagandha supports a healthy immune system. The product is listed with the following certifications and classifications: Non-GMO, Kosher, Dairy Free, Egg Free, Nut Free, Soy Free, Vegan/Vegetarian, and Made without Gluten. The page states that NOW holds NPA A-rated GMP certification, meaning that every aspect of the NOW manufacturing process has been examined, including laboratory and testing methods for stability, potency, and product formulation. NOW is described on the page as founded in 1968 by Elwood Richard and as one of the largest independent, family- and employee-owned manufacturers of natural products. The listing belongs to the NOW store on Walmart, and the page includes Brand Highlights from Syndigo covering NOW quality, low pricing, and the company's commitment to quality testing, with an infographic comparing NOW to other brands. The listing is sold in a single 90-count option at the displayed price of $8.14, which the page shows as 9.0 cents per count. A 2-pack bundle of the same product is also linked on the page at $14.38. Shoppers can continue searching on Walmart using related terms such as ashwagandha, now supplements ashwagandha, and ashwagandha vegan. The detailed Ingredients, Warnings, Directions, and Specifications sections are present as headings but their contents did not load in the scraped text, so this description is limited to the key item features and brand statements visible above. Customers reviewing the product on this page have given it an average of 4.6 out of 5 stars across 161 ratings.
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Study, Trial or Testing Result Summary
Members Only28 human studies · 25 improved
This product gives ashwagandha root and leaf extract at a full dose, well above the lowest amount that worked in studies. A large 2026 review of 23 placebo-controlled trials with 1706 adults found ashwagandha lowered cortisol, the main stress hormone made by the adrenal glands, compared with placebo [1]. A 2024 review of nine trials with 558 people found lower cortisol, stress and anxiety [2]. A 2025 review of 488 people also found cortisol fell, but stress scores did not change significantly [3]. In a 2026 trial, 141 stressed adults taking 600 mg a day for 8 weeks had lower cortisol, stress and anxiety than those on placebo [4]. In a 2021 trial, 130 stressed adults taking 300 mg a day for 90 days had lower stress and cortisol and better sleep [5]. In a 12 month study of 191 adults, cortisol fell, no serious safety problems appeared, and most were rated as improved [6]. Doses as low as 125 mg a day reduced stress in 8 to 12 week trials. One review noted that no trial directly tested adrenal gland function, so the support here rests on cortisol and stress measures. Animal and cell studies are never counted.
See all 28 studies →Hide the studies
- Across 23 placebo-controlled trials with 1706 adults, ashwagandha lowered cortisol compared with placebo, raised serotonin and thyroxine modestly, and raised testosterone in men but not women.Hormonal Modulation with Withania somnifera: Systematic Review and Meta-Analysis of Randomized-controlled Trials.
- Across nine randomized trials with 558 people, ashwagandha lowered blood cortisol, perceived stress and anxiety scores compared with placebo, with mild to moderate side effects in four trials.Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis.
- Across seven to eight randomized trials with 488 people taking at least 250 mg daily, ashwagandha lowered cortisol by about 1.16 micrograms per deciliter but did not significantly change perceived stress.Dual impact of Ashwagandha: Significant cortisol reduction but no effects on perceived stress - A systematic review and …
- In a review of 52 trials of plant products, the most consistent finding was that ashwagandha lowered morning cortisol, while effects of most other plants were unclear.Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human t…
- In nine trials of stressed people lasting 30 to 112 days, ashwagandha lowered cortisol without significant side effects, but no trial checked effects on adrenal function or long-term outcomes.Effects of Withania somnifera on Cortisol Levels in Stressed Human Subjects: A Systematic Review.
- A review of 19 ashwagandha trials using 120 to 1000 mg daily for 3 to 16 weeks reported less stress and anxiety, better sleep and favourable hormonal changes, though the trials were small and varied.Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecu…
- A review of 14 ashwagandha studies using 30 to 600 mg daily found benefits for anxiety, stress and sleep with a pooled cortisol reduction of 3.27 micrograms per deciliter, and noted liver safety concerns.Efficacy and Safety of Saffron and Ashwagandha for Stress-Related Mental Health Outcomes: A Systematic Review of Randomi…
- In 186 stressed adults over 60 days, full-spectrum ashwagandha root reduced perceived stress, anxiety and improved sleep quality more than placebo, with no change in mental alertness.Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled…
- In 141 stressed adults, 600 mg a day of a proprietary ashwagandha root extract for 8 weeks lowered cortisol, stress and anxiety scores, and it beat both standard ashwagandha extract and placebo on stress, anxiety and mood scores.A proprietary herbal extract of ashwagandha root for stress and anxiety in healthy adults: a randomized, double-blind, t…
- In 135 adults with functional constipation, a blend of ashwagandha root and okra fruit extract (300 or 500 mg a day) for 60 days eased constipation, lowered cortisol and the inflammation marker IL-6, and improved sleep, anxiety and depression symptoms.A Novel Herbal Composition Alleviates Functional Constipation, Reduces Gastrointestinal Transit Time, and Improves Bowel…
- In 135 stressed healthy adults, 150 or 300 mg a day of sustained-release ashwagandha for 60 days reduced perceived stress and improved sleep, eating behavior and well-being versus placebo, and the 300 mg dose also lowered cortisol.Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects…
- In 130 stressed healthy adults, 300 mg a day of sustained-release ashwagandha for 90 days lowered stress scores and cortisol and improved memory, sleep quality and well-being compared with placebo.Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double…
- In 98 chronically stressed adults, a water-extracted ashwagandha root and leaf extract at 125 mg daily for 8 weeks reduced perceived stress compared with placebo, with effects that increased at higher doses of 250 and 500 mg.Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial.
- In 91 adults analyzed from 100 randomized, 600 mg daily of ashwagandha root extract for 24 weeks reduced body weight and stress scores more than placebo, with only mild side effects reported.Efficacy and safety of Ashwagandha (Withania somnifera) root extract on stress and weight management in adults: a prospe…
- In 90 adults with mild to moderate stress, 125 mg daily of the Zenroot ashwagandha formulation for 84 days improved stress scores, anxiety, mood and sleep quality compared with placebo, and was well tolerated.A New Ashwagandha Formulation (Zenroot™) Alleviates Stress and Anxiety Symptoms While Improving Mood and Sleep Quality: …
- In a 60-day placebo-controlled trial of 64 stressed adults, 300 mg of ashwagandha root extract twice daily lowered stress scores and serum cortisol compared with placebo, with mild side effects similar to placebo.A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spe…
- In a 60-day placebo-controlled trial of 60 stressed adults, 240 mg of Shoden ashwagandha extract once daily produced greater reductions in morning cortisol and the adrenal hormone DHEA sulfate than placebo and lowered anxiety scores.An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A…
- In an 8-week placebo-controlled trial of 60 stressed adults, ashwagandha root extract at 250 mg/day and 600 mg/day reduced perceived stress and serum cortisol, and the groups taking it reported better sleep quality than placebo.Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-co…
- In a 30-day placebo-controlled trial of 60 stressed adults, ashwagandha root and leaf extract at 400 mg or 225 mg daily lowered cortisol over time and improved some thinking skills compared with placebo, but mood and stress questionnaire results did not differ by group.Efficacy of Withania somnifera supplementation on adult's cognition and mood.
- In 60 women aged 45 to 55, ashwagandha root extract for 56 days reduced menopausal symptoms and stress scores more than placebo, and improved some hormone levels.A prospective, randomized, double-blind, placebo-controlled study on efficacy and safety of Ashwagandha root extract (Wi…
- In a 60-day placebo-controlled trial of 60 adults with stress, anxiety and high blood pressure, 300 mg of Ashwagen twice daily cut serum cortisol by 28.99% along with reducing anxiety and stress scores.Safety and efficacy of ashwagen (a standardized withania somnifera extract) in stress and anxiety with hypertension and …
- In a 16-week crossover trial of 57 overweight men aged 40 to 70, 21 mg a day of Shoden ashwagandha extract over 8 weeks raised the hormone DHEA sulfate and testosterone more than placebo, but cortisol and estradiol did not differ and feelings of fatigue and vigor did not improve more than placebo.A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagand…
- In 56 team sports athletes, 600 mg daily of ashwagandha root extract for 42 days stopped the rise in stress hormone cortisol seen with placebo, improved recovery feelings in female athletes, and increased jump performance in male athletes.Ashwagandha Root Extract Stabilises Physiological Stress Responses in Male and Female Team Sports Athletes During Pre-Se…
- In a 60-day placebo-controlled trial of 54 healthy adults taking 500 mg of standardized ashwagandha root extract nightly, morning salivary cortisol fell more than with placebo, alongside better stress and anxiety scores.A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by mo…
- In an 8-week placebo-controlled trial of 52 adults under chronic stress, 300 mg of ashwagandha root extract twice daily improved stress, food cravings, happiness and body weight measures, with serum cortisol among the secondary measures that improved.Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, R…
- In 50 healthy athletic adults, ashwagandha root extract at 300 mg twice daily for 8 weeks improved maximum aerobic capacity and recovery scores more than placebo, with no adverse events reported.A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extra…
- In a 14-day placebo-controlled trial of 48 adults with functional constipation, 500 mg a day of a blend of ashwagandha root and okra fruit extract lowered cortisol and IL-6 and reduced stress, with no adverse events reported.A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipatio…
- In 191 healthy adults taking ashwagandha root extract for 12 months, no clinically significant safety problems appeared, serum cortisol fell, quality of life improved, and 68.7% of patients were rated as improved overall.Safety of 12-Months Administration of Ashwagandha ( Withania somnifera ) Standardized Root Extract in Healthy Adults: A …
Review Totals and Summary
Members Only81,536 reviews · 92% positive
Across the stores that sell it, Ashwagandha 450 mg from NOW carries about 59,821 ratings. Buyers are mostly happy: the large majority give 4 or 5 stars, and calm and stress relief are what they mention most. **What buyers say it did for them:** Most reviewers take it for stress, calm and relaxation. One says it helps them "feel calm," and another describes "a subtle but steady sense of calm." Some mention better sleep, with one saying "Sleep has become much better with this supplement." Others mention mood, such as "Great for menopausal mood swings." One reviewer says it helps their depression after meds did not. The store summary adds that a few people noticed more energy, and that some only saw benefits after several weeks of steady use. **What buyers complain about:** Complaints are few but real. One reviewer reports it was "the worst and most useless supplements i ever purchased," with dizziness, nausea and vomiting. The store summary says others had milder stomach upset, drowsiness or nausea, and some noticed no real change. One buyer received the wrong item: "This is not what I ordered." The page also notes it is not recommended for everyone, and reviewers repeat the advice to check with a doctor before starting. **Taste, smell, pill size and form:** The capsules are described as small to medium, vegetarian and easy to swallow. One reviewer says "The capsules are small and easy to swallow," and another calls them "gentle on the stomach." Opinions on taste differ. One reviewer finds it "quite strong in potency, smell & taste," while the store summary says several found no unpleasant smell or taste. Reviewers also like the jar and its convenient lids. **Value for money:** Buyers see it as good value. One says "Trusted company, good price," and another calls the capsules "affordable." The store summary describes the 90-capsule bottle as excellent value and says buyers trust NOW Foods for clean, reliable products. One reviewer likes that it is a standardized extract, which gives confidence in consistency. **Who it seems to suit and who it did not:** It seems to suit people looking for a natural way to feel calmer and manage everyday or chronic stress, and some who want help with sleep or mood. Several are long-term users, including one who has taken it for six years. One reviewer says the 450 mg dose is "just right for me." It did not suit the buyer who became dizzy and sick, nor those who noticed no change. Buyers who expect fast results may be disappointed, since some needed several weeks. Reviews of other forms of this product, such as gummies or powder, were left out; this summary covers the capsules only.
Biohacker Summary
Members Only9 of 10 recommend it
Most of the panel recommends or uses ashwagandha, mainly to lower cortisol, ease stress and anxiety, and improve sleep, with several taking it at night or late in the day; a few add that it may help testosterone. Doses named are 250 mg a day, 400 to 600 mg, and a wider range of 120 to 1,000 mg for at least six weeks, and two panelists prefer standardized branded extracts. Several cite human trials, though one calls the data weak and another finds it only a little helpful for sleep and not for everyone. Cautions are common: some advise cycling it, such as two weeks on and two weeks off, others warn it can cause emotional numbing, irritability in women, or feeling weird, and one says it is wrong for low cortisol. One panelist stopped taking it because it caused a mouth sore, and a few pair it with other calming herbs such as rhodiola and lemon balm.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Ashwagandha · recommends
- Lists ashwagandha as an herb that can help lower anxiety or depression symptoms.
- Notes that there was a recent study on ashwagandha for sperm health, indicating it's an evolving area of research.
- Suggests trying ashwagandha, noting that some people respond to it, and recommends a dose of 400 to 600 mg.
- Recommends adaptogenic herbs like ashwagandha, particularly at night, rhodiola, lemon balm, and catclaw for stress relief.
- Recommends ashwagandha at night as an adaptogen to help with high cortisol and promote sleep for those who are tired and wired.
- Recommends ashwagandha, stating it can help convert T4 to T3, but advises ensuring a clear source and monitoring liver enzymes.
- Suggests adaptogens like rhodiola, ashwagandha, ginseng, and Siberian ginseng can be helpful for actively managing stress.
- States that Mosh protein bars contain ashwagandha to support a healthy brain.
- Recommends adaptogens like Ashwagandha if one has a lot of stress.
- States that ashwagandha can stimulate osteoblasts, which helps with bone building, especially for those with a genetic predisposition to low bone density.
Dr. Eric Berg · Ashwagandha · recommends
- Recommends ashwagandha, suggesting 250 milligrams per day over time to increase stress tolerance and help the cortisol receptor.
- Rates Ashwagandha on a scale from 1 to 10.
- Lists ashwagandha as one of the best ways to lower luteinizing hormone, which goes too high as people age and is related to dementia.
- Notes that some people take ashwagandha or other adaptogens to help calm them down when they assume their problem is cortisol, and sometimes it works.
- States that taking ashwagandha on a regular basis can greatly help the adrenals.
- Recommends Ashwagandha to help make the process of quitting coffee smoother.
- Recommends taking adaptogens like ashwagandha for super powerful and real energy inputs without artificial side effects.
- Recommends Ashwagandha to help sleep through the night.
- Recommends taking Ashwagandha in the evening before bed as a remedy for problems with elevated cortisol around 2 AM, when cortisol should be at its lowest point.
- Recommends trying ashwagandha to lower stress levels.
Siim Land · Ashwagandha · recommends
- Recommends Ashwagandha for stress, sleep and performance, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Ashwagandha as one of 15 supplements backed by human studies.
- Notes that Ashwagandha is one of several supplements with human evidence.
- States that ashwagandha, unless contaminated, is not going to raise liver enzymes.
- Stopped taking ashwagandha because it immediately caused a mouth sore.
- States that ashwagandha consistently reduces stress and anxiety in randomized controlled trials.
- States that Ashwagandha helps with testosterone primarily in stressed out or poor sleeping people.
- States that ashwagandha has strong evidence for increasing testosterone, mostly in stressed or infertile men.
- Mentions ashwagandha as an example of a testosterone-boosting supplement he has no interest in taking.
- Places Ashwagandha, specifically the KSM66 form, in the 'god tier' due to extensive research supporting its benefits for stress, sleep, testosterone production, estrogen, and even V2 max, while personally not experiencing any negative side effects some people report.
Thomas DeLauer · Ashwagandha · recommends
- Recommends ashwagandha extract, noting a study where 57 overweight men over 40 saw a 14.7% increase in testosterone and an 18% increase in DHEA over 16 weeks, suggesting it removes the cortisol block suppressing the entire hormonal cascade.
- Mentions ashwagandha as part of a full testosterone protocol, supporting production through different pathways.
- Recommends ashwagandha, noting it modulates the HPA axis and dropped cortisol by approximately 23% in 60 days, but advises cycling it, especially if feeling emotionally numb.
- Cautions against Ashwagandha due to its potential for emotional numbing effects.
- Suggests ashwagandha at night to help regulate cortisol, but advises playing around with it as some people find it makes them feel weird.
- Recommends Ashwagandha, Rhodiola, and Ginseng as adaptogens to help the body adapt to stress, bring cortisol levels back to homeostasis, and support heat shock proteins and stress chaperoning pathways, especially when in a caloric deficit.
- Recommends Ashwagandha in the evening time for its anti-cortisol effect, helping to regulate cortisol for better balance in the morning.
- Recommends ashwagandha as an adaptogen with a profound effect on cortisol, acknowledging that it can make some people feel numb but may still be helpful.
- Discusses Ashwagandha as an adaptogen with quite a bit of evidence for various benefits like cognitive ability, stress, stamina, cardiovascular benefits, and lipid panels. He notes that long-term use might lead to a level of tolerance or an apathetic sense, suggesting it should be used when sincerely needed.
- Recommends Ashwagandha to help regulate oxidative stress.
Ben Greenfield · Ashwagandha · neutral
- Ashwagandha, taken as 120–1,000 mg for at least 6 weeks, with most studies providing a dose of 400–600 mg/d, can lower cortisol levels, improve sleep quality, and enhance cognitive resilience for athletes during challenging phases consisting of high-volume resistance training.
- Notes that ashwagandha is an ingredient in MTE.
- Mentions Ashwagandha as a supplement people cycle through when still sleeping poorly, suggesting it might not be addressing the true sleep problem.
- Notes that ashwagandha is a nightshade herb, but it is taken as a supplement and not used for cooking.
- States that Ashwagandha helps regulate stress response and steady the nervous system, influencing biological systems tied to sleep quality.
- Has found that adaptogens like ashwagandha, taken about half an hour before using the Shift Wave, seem to enhance its effects on tuning up the nervous system. He also found it helped him and his co-founder achieve slower respiratory heart rate coherence.
- Uses Ashwagandha, as part of IM8 Health, to quiet the stress response for sleep.
- Mentions ashwagandha as an herb that has more data than fruit tree leaves.
- Ben Greenfield notes that IM8 contains ashwagandha, an adaptogen, to help manage stress and support the immune system.
- Sometimes takes ashwagandha to help get back to sleep if he wakes up in the middle of the night.
Dave Asprey · Ashwagandha · neutral
- Dave Asprey notes that ashwagandha, when taken as a real standardized extract at a real dose, genuinely lowers cortisol and shows effects on stress and sleep quality in randomized trials, but lacks polysomnography data.
- Dave Asprey discusses ashwagandha as part of an adaptogen trio that works together for stress response and human performance.
- Mentions ashwagandha as an adaptogen in MTE that helps blunt the cortisol spike.
- Advises against ashwagandha for low cortisol, stating that salt and water are needed instead.
- Warns that ashwagandha can raise testosterone in women, causing irritability, and therefore needs to be cycled.
- Dave Asprey mentions ashwagandha as a supplement and cofactor that supports thyroid activation.
- Recommends ashwagandha as a cofactor that can help thyroid function, especially with conversion issues.
- Dave Asprey lists ashwagandha as part of a supplement stack that supports healthy hormone levels.
- Discusses ashwagandha as a common adaptogenic herb used by biohackers to deal with stress, noting it was banned in Denmark and can cause anhidonia and reduced ability to reach orgasm at higher doses.
- The episode discusses the dangers of chronic ashwagandha use.
Peter Attia · Ashwagandha · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Finds ashwagandha a little bit helpful for sleep, though notes it may not be for everyone.
- Finds ashwagandha "a little bit helpful" for sleep, but notes that it may not be for everyone.
- Finds ashwagandha a little bit helpful for sleep, but notes it may not be for everyone.
- States that the data for ashwagandha are weak.
- Discusses the current evidence for ashwagandha's effects on sleep, stress, and anxiety.
- Mentions ashwagandha as an evergreen shrub historically used in traditional Indian medicine for indications such as sleep, stress, and immune health.
- Mentions ashwagandha as something that can help with sleep in the setting of chronic stress and hypercortisolemia.
- Takes 600 mg of Solgar ashwagandha at night, having recently switched to this brand and returned to taking it after a previous hiatus.
- Takes 600 milligrams of ashwagandha at night, having recently switched to the Solgar brand and having returned to taking it after a long break.
Andrew Huberman · Ashwagandha · recommends
- He shares science-based tools for modulating aggression, including supplementation with ashwagandha.
- Warns that while ashwagandha is a potent inhibitor of cortisol, chronic supplementation for longer than two weeks can disrupt other hormone and neurotransmitter pathways, so it should be used with a two-week break after two weeks of use.
- Recommends Ashwagandha as a supplement to reduce cortisol.
- Explains how to optimize hormone levels through supplements such as ashwagandha.
- Mentions ashwagandha as a potent commercial compound in supplement form that can be used to reduce chronic stress, especially late in the day, by significantly decreasing cortisol.
- Discusses Ashwagandha as a supplement to better manage stress.
- Uses ashwagandha when feeling particularly stressful to lower anxiety and cortisol, but does not take it year-round or on a regular basis.
- Takes ashwagandha for sleep.
- Recommends Ashwagandha as a good adaptogen, but advises cycling it if taking high doses due to potential issues with liver and thyroid.
- Warns that taking ashwagandha as a prophylactic or before training is counterproductive because it blunts cortisol, which can cause immunosuppression and suppress adaptation.
Dr. Rhonda Patrick · Ashwagandha · recommends
- Recommends Ashwagandha supplementation, specifically standardized for withanolides (KSM-66 at 5% or Sensoril at 10%), to indirectly boost testosterone by reducing cortisol levels, and also to improve anxiety, stress resilience, and sleep quality.
- Recommends ashwagandha, specifically patented extracts like Sensoril or KSM66 standardized to sufficient quantities of withanolides, for its indirect effect on testosterone by suppressing cortisol and stress response, which can be beneficial for anxious individuals and improve sleep.
- Is very bullish on Ashwagandha, citing meta-analyses showing improved lean mass, strength, sleep, and stress management. He notes it also raises testosterone but not enough to explain the lean mass changes.
- Discusses ashwagandha.
- Uses ashwagandha as a supplement to help with sleep.
- Dr. Rhonda Patrick discusses curcumin & ashwagandha safety.
- His regular sleep supplements are glycine, ashwagandha, magnesium L-threonate, and magnesium oxide.
- She mentions that Peter Attia takes 600 milligrams of ashwagandha from Solgar.
Bryan Johnson · Ashwagandha · uses
- Drinks his Blueprint longevity mix with additional morning supplements, including ashwagandha.
- States that Blueprint Ashwagandha can be used to stabilize mood.
- Mentions that Ashwagandha is included in the LA Longevity Mix, which condenses his 100 daily pills into a drink.
- Mentions ashwagandha as a potential therapy that could positively influence sperm health.
- Mentions ashwagandha as an ingredient in his 'bag of goodies', indicating he uses it.
- Takes ashwagandha for anti-anxiety, improved cortisol management, improved sleep, and increased testosterone.
- Recommends ashwagandha at 300 to 600 mg daily to support stress resilience and overall well-being during the luteal phase for women.
- Ashwagandha + Rhodiola is part of the Blueprint protocol for energy and stress support.
- Suggests ashwagandha as an optional supplement to support calmness and resilience during stress, and to support the body's healthy response to stress.
- Lists "Ashwagandha + Rhodiola" with "120mg" as part of his supplements, implying its use.
RAL Summary
Members OnlyTier 2 for Adrenal Support
Many placebo-controlled human trials and pooled reviews show ashwagandha lowers cortisol and stress, and over 81,000 reviews are 92% positive, which meets the rule for tier 2.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Nervous system
Combine with: Ashwagandha is an adaptogen that has been shown in clinical trials to lower cortisol and perceived stress, which makes it a logical fit for adrenal (HPA-axis) support. To broaden the effect, consider pairing it with Rhodiola rosea for fatigue resistance, Holy Basil (tulsi) for further cortisol modulation, and Eleuthero or Panax ginseng for daytime energy. Vitamin C (500-1000 mg) and a B-complex, especially B5 (pantothenic acid) and B6, support adrenal hormone synthesis and the stress response. Magnesium glycinate helps with relaxation and sleep quality, and phosphatidylserine can blunt an excessive evening cortisol rise. Omega-3 fish oil and vitamin D support general stress resilience. Those with thyroid conditions, autoimmune disease, or who are pregnant, or taking sedatives, meds, or immunosuppressants should consult a healthcare provider before using ashwagandha.
Possible side effects: Trials reported mild to moderate side effects in some studies, and no serious safety problems over 12 months. Buyers mention occasional stomach upset, drowsiness or nausea, and one reported dizziness and vomiting.
Supplement Facts
Ashwagandha Extract 450 mg
| Ashwagandha Extract (Withania somnifera) (Root and leaf) (min. 2.5% Total Withanolides - 11 mg) | 450 mg | † |
Other ingredients: Hypromellose (cellulose capsule), stearic acid (vegetable source) and rice flour.
Directions: Take 1 capsule 2 to 3 times daily.
Label source: iHerb · Report a label change
Sizes and barcodes: 90 Veg Capsule(s), UPC 7 33739 04603 1 (on market); 180 Veg Capsule(s), UPC 7 33739 04593 5 (on market)
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Graded November 15, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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