Black Forest THE PROTOCOL™ Review
THE PROTOCOL™ is a morning supplement stack from Black Forest Supplements. The brand's stacks page describes it as an "Editor's Pick" aimed at men who feel their vitality slipping. It combines three systems and three compounds into one morning routine. The compounds are NMN for cellular energy, cocoa flavanols for blood flow, and Turkesterone with Tongkat Ali for testosterone. The brand says it is meant to reclaim the three systems men lose after 30. Black Forest sells the components individually. I couldn't confirm the exact bundle doses on the page I read, so the doses below come from the individual products. NMN (nicotinamide mononucleotide) is a precursor to NAD⁺. NAD⁺ is a coenzyme that mitochondria use in energy metabolism, and it is also used by repair enzymes such as sirtuins and PARPs. NAD⁺ levels fall with age, so supplementing a precursor is meant to restore the cell's supply. Black Forest's NMN is sold at 1000mg per serving. It is described as 99% pure and stabilized, and it is paired with BioPerine®, a black pepper extract that is meant to improve absorption. The cocoa flavanol product is Supercharged Cocoa Flavanols + Flavonoids 1200mg. An independent review says it supplies 600mg of standardized epicatechin plus 600mg of flavonoids per serving. Flavanols are thought to support endothelial nitric oxide production, which helps blood vessels relax and supports normal blood flow. The same review notes that the EFSA-authorized claim covers only normal blood flow at about 200mg of flavanols a day. It also notes that the large COSMOS trial was inconclusive on hard cardiovascular events. Turkesterone is an ecdysteroid from Ajuga turkestanica. The brand sells it at 500mg per capsule and describes it as 95% pure. Marketing says it supports muscle building and performance. Its proposed mechanism is signaling through estrogen receptor beta and anabolic pathways, rather than through the androgen receptor. Human evidence for this is limited. Tongkat Ali (Eurycoma longifolia) is a traditional Southeast Asian root extract. It is studied for its possible effect on free testosterone, partly by reducing SHBG binding and supporting the hormone axis. The brand says its products are third-party tested, made in the USA in an FDA-registered, GMP-certified facility, and free of GMOs and gluten. It also advertises free shipping and a 60-day guarantee. As with any dietary supplement, the FDA has not evaluated these claims. People who are on blood pressure or hormone-related medication should talk to a clinician before taking it.
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Study, Trial or Testing Result Summary
Members Only117 human studies · 62 improved
Zinc is the only ingredient here at a dose that worked in a study. In 50 overweight people with fatty liver on a diet, 30 mg daily for 8 weeks lowered weight and waist size more than placebo [1]. In 98 men and women with pre-diabetes, the same dose for up to a year did not change weight or waist [2]. Artichoke leaf reaches a studied dose at two servings a day. Pooled trials found it modestly lowered body mass index and waist size but not body weight [3][4]. Turmeric is well below the studied dose, though curcumin lowered weight across many trials [5]. Milk thistle did not change body mass index in pooled trials [6][7]. Beetroot did not change weight or body fat in pooled trials [8]. Choline is at a very small dose, and a higher dose did not change weight loss [9]. Burdock, chanca piedra and dandelion have only animal or uncontrolled evidence [10][11][12]. The contents of the 416 mg proprietary blend are not given. Animal and cell studies are never counted.
See all 117 studies →Hide the studies
- Across 103 placebo-controlled trials with 7216 people, curcumin lowered body weight along with blood sugar, inflammation and other markers, with high certainty of evidence for weight.Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.
- In a pooled analysis of 111 trials of 6171 adults with overweight or obesity, curcumin led to a small weight loss of about 0.8 kg versus control, with moderate certainty of evidence.Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and netwo…
- In 37 trials with 2,509 people with fatty liver, high-dose catechins lowered body mass index the most; silymarin was not highlighted for weight.Effects of different natural products in patients with non-alcoholic fatty liver disease-A network meta-analysis of rand…
- In a review of trials with 2,173 people with fatty liver, silymarin reduced liver enzymes, but body mass index reductions were reported for curcumin, hesperidin and catechin, not silymarin.Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A syste…
- In 21 studies of 1604 people with metabolic syndrome and related conditions, curcumin reduced body weight, body mass index, waist size and leptin, but did not change the hip ratio.The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review…
- Across 17 trials with 1,337 people with type 2 diabetes, silymarin improved blood sugar measures, but body weight benefit was found for curcumin and resveratrol, not silymarin.Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients Wit…
- In eight trials of 520 people with fatty liver disease taking 70 to 3000 mg daily for 8 to 12 weeks, curcumin reduced body mass index and waist size but not body weight.The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalc…
- A pooled analysis of observational studies found blood zinc was lower in obese children and adults than in non-obese people, but not significantly lower in overweight adults; it did not test zinc supplements.The association between serum zinc level and overweight/obesity: a meta-analysis.
- Eight placebo-controlled trials in people with fatty liver showed silymarin lowered liver enzymes regardless of weight loss; the abstract does not report a body weight benefit.Impact of Silymarin in individuals with nonalcoholic fatty liver disease: A systematic review and meta-analysis.
- In 11 trials in adults, silymarin lowered blood sugar and cholesterol compared with placebo but did not significantly change body mass index.The effects of Silymarin on the features of cardiometabolic syndrome in adults: A systematic review and meta-analysis.
- In nine trials of people with fatty liver disease, silymarin lowered liver enzymes and triglycerides but did not significantly change body mass index.Effects of silymarin use on liver enzymes and metabolic factors in metabolic dysfunction-associated steatotic liver dise…
- Pooling seven randomized trials in people with metabolic syndrome, curcumin or turmeric improved blood sugar, triglycerides, HDL cholesterol and diastolic blood pressure but did not significantly change waist circumference.Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta-analysi…
- In nine trials in people with fatty liver disease, curcumin reduced waist size, liver enzymes and blood sugar but not body weight or body mass index overall.The effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-a…
- In eight trials of head and neck cancer patients after radiotherapy, turmeric reduced mouth sores and pain, and patients lost less weight than the control group at the final follow-up.Efficacy of turmeric in the treatment of oral mucositis in patients with head and neck cancer after radiotherapy or chem…
- In seven placebo-controlled trials in people with fatty liver disease, phytosomal curcumin reduced weight by about 2 kg, body mass index, body fat percentage and waist size, but not hip size.Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis.
- Across twelve randomised trials, beetroot or nitrate supplements did not change body weight, BMI, fat mass, waist size, body fat percentage or fat-free mass, regardless of dose, duration or athletic status.The effects of beetroot and nitrate supplementation on body composition: a GRADE-assessed systematic review and meta-ana…
- Across 10 randomized trials, artichoke reduced waist circumference by about 1.1 cm but did not significantly change overall weight or body mass index, though weight fell in people with high blood pressure.The effects of supplementation with Cynara scolymus L. on anthropometric indices: А systematic review and dose-response …
- Pooling trials in adults, artichoke supplements modestly lowered body mass index and waist circumference but did not significantly change body weight or hip size.Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence.
- In a review of 32 studies of people after weight-loss surgery, about 17.6% regained 10% or more of their weight, and higher zinc consumption was linked to less weight regain, though zinc was not tested as a supplement.Factors associated with weight regain post-bariatric surgery: a systematic review.
- In 34 randomized trials of 2580 adults having cancer treatment, curcumin gave mixed results on weight change and body composition, with some significant findings for less weight loss, but all studies had moderate to high risk of bias.Curcumin as a complementary treatment in oncological therapy: a systematic review.
- This review concluded that excessive zinc intake may contribute to obesity, diabetes and heart risks, while optimal zinc levels appear protective, with no weight results given in the abstract.The Dual Edge of zinc: linking excessive intake to obesity, diabetes, hypertension, and cardiovascular risks.
- Across eight randomized trials in adults, regular curcumin over short periods did not change body measures, while three trials using more absorbable curcumin or longer treatment showed weight benefits.Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials.
- This review of nutraceuticals for fatty liver concluded that curcumin, if well dosed and taken for medium to long periods alongside lifestyle changes, could improve fatty liver and related body and blood measures.Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence.
- In women with polycystic ovary syndrome, curcumin was associated with lower body mass index across five included trials.Complementary administration of curcumin in PCOS: a systematic review.
- In a review of trials in adults with fatty liver disease, beetroot juice was among plant foods linked to better lipids, liver enzymes and liver fat, but beetroot was not listed among those that improved body measurements.Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such …
- In a 12-month placebo-controlled trial of 272 adults with type 2 diabetes, 1,500 mg per day of curcumin extract lowered body weight and body mass index compared with placebo, along with improved blood sugar measures.Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial.
- In 250 men with metabolic syndrome, 2.4 g daily of turmeric for eight weeks improved body fat and LDL cholesterol relative to placebo, and at four weeks lowered BMI and waist circumference from baseline.Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind …
- In 200 women with PCOS taking 80 mg of nanocurcumin every 8 hours for 12 weeks, combined with a med, body weight and BMI fell more than with placebo or single agents; the abstract does not report curcumin alone separately.Read the study on PubMed (39461199) →
- In 150 adults with fatty liver disease, 140 mg of silymarin daily for 3 months lowered liver enzymes, and all groups including placebo with lifestyle changes improved waist size and body mass index.Treatment options for nonalcoholic fatty liver disease: a double-blinded randomized placebo-controlled trial.
- In 136 obese people with type 2 diabetes, a berberine and silymarin combination for 52 weeks improved body mass index, waist size and abdominal fat compared with placebo.Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week dou…
- In 134 patients with abnormal blood fats, one tablet a day of a red yeast rice, milk thistle and octasonol combination for 3 months improved cholesterol and inflammation markers compared with placebo; body weight and BMI were measured, but the abstract reports no weight benefit.A randomized, placebo-controlled study on the effects of a nutraceutical combination of red yeast rice, silybum marianum…
- In 105 overweight patients with abnormal blood fats, a berberine and milk thistle combination taken twice daily for 3 months improved cholesterol, insulin resistance and fat-hormone levels compared with placebo; the abstract does not report a change in body weight.Effects of Berberis aristata/Silybum marianum association on metabolic parameters and adipocytokines in overweight dysli…
- In adults with fatty liver disease, 1000 mg of phytosomal curcumin daily for 8 weeks lowered body mass index and waist circumference more than placebo, with 87 people completing the trial.Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
- In 102 people with fatty liver, 300 mg a day of a bergamot and wild cardoon supplement for 12 weeks reduced liver fat more than placebo, with benefits also seen in body weight.Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Indiv…
- In 100 obese adults with metabolic syndrome, Calebin A from turmeric for 90 days reduced body weight, waist size, and body mass index more than placebo, and also lowered inflammation markers.A minor metabolite from Curcuma longa effective against metabolic syndrome: results from a randomized, double-blind, pla…
- In 100 adults with type 2 diabetes, 80 mg of nano-curcumin with EPA for 12 weeks lowered insulin and hs-CRP compared with placebo, but weight was not reported as an outcome.The effect of curcumin and high-content eicosapentaenoic acid supplementations in type 2 diabetes mellitus patients: a d…
- In 98 men and women with pre-diabetes, 30 mg of zinc gluconate daily for up to 12 months did not change blood sugar or secondary measures including body weight and waist size compared with placebo.The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial.
- In 94 adults with fatty liver, 300 mg a day of a bergamot and wild cardoon supplement for 6 weeks lowered uric acid more than placebo; weight outcomes were not reported in the abstract.Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease.
- In 92 adults with fatty liver disease, 3 grams of turmeric daily for 12 weeks raised HDL cholesterol compared with placebo, but BMI and waist size fell only in groups that took chicory seed.Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver dise…
- In 88 adults with metabolic syndrome, 12 weeks of curcumin did not change body weight or BMI compared with placebo, although it lowered triglycerides and cholesterol.Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a rand…
- In 85 people with type 1 diabetes, a berberine and milk thistle tablet twice daily for 6 months reduced insulin dose, blood sugar and cholesterol compared with placebo; the abstract reports no weight outcome result.The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus.
- In overweight adults with prediabetes, 500 mg curcumin daily for 90 days did not change weight compared with placebo, while zinc alone and zinc with curcumin lowered BMI and all three treated groups improved blood sugar measures.The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A…
- In 83 adults with fatty liver disease, 103.2 mg of silymarin daily for 24 weeks reduced liver stiffness but had no significant effect on body mass index, waist-to-hip ratio or body fat compared with placebo.Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated ste…
- In 80 adults with type 2 diabetes and high cholesterol, 2100 mg of turmeric powder daily for 8 weeks reduced body mass index and some cholesterol measures more than placebo, but did not change blood sugar or inflammation markers.Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 di…
- In 80 adults with fatty liver disease, 250 mg of curcumin phytosome daily for 2 months reduced liver fat and liver enzyme levels compared with placebo, with no difference in weight changes between groups.The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Ra…
- In 80 adults with fatty liver disease, 500 mg of curcumin daily for 24 weeks reduced body weight by about 2.6 kg and BMI compared with placebo.Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid…
- In 78 adults with type 2 diabetes and fatty liver disease, 1500 mg of curcumin daily for 12 months reduced body fat, BMI and inflammation compared with placebo.Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Stea…
- In 77 overweight adults taking a nutraceutical blend containing silymarin for 90 days, body weight and waist-to-height ratio decreased, and inflammatory markers improved, though the study did not isolate silymarin's effect alone.Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausni…
- In 72 adults with type 2 diabetes and high triglycerides, 500 mg of curcuminoids with 5 mg piperine daily for 12 weeks lowered triglycerides and fasting blood sugar more than placebo, but did not change body mass index or waist size.The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in pa…
- In 72 adults with type 2 diabetes and heart disease risk, 500 mg of curcumin three times daily lowered blood pressure and inflammation but did not change BMI compared with control.Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular ris…
- In 68 overweight or obese adults with fatty liver disease, adding a silymarin-containing supplement to a Mediterranean diet for 3 months improved liver fat more than the diet alone.The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of…
- In 66 adults with metabolic syndrome, 500 mg of curcumin daily for 12 weeks reduced body weight compared with placebo and improved arterial stiffness.The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-…
- In 66 adults recovering from ischemic stroke, 500 mg of curcumin with 5 mg piperine daily for 12 weeks reduced body weight and waist size more than placebo, and also lowered inflammation (hs-CRP).The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients wit…
- In 60 overweight adolescent girls, 500 mg of turmeric curcumin daily for 10 weeks did not produce significant differences in BMI or waist size compared with placebo after analysis.Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial…
- In 60 women with polycystic ovary syndrome, 500 mg of curcumin daily for 12 weeks reduced body weight and body mass index more than placebo, along with improved blood sugar and cholesterol.Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomi…
- In oral cancer patients receiving radiation and chemotherapy, a bio-enhanced turmeric formulation at 1 g or 1.5 g daily for six weeks reduced severe mouth sores and weight loss compared with placebo.A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced …
- In adults with fatty liver, 500 mg curcumin plus piperine daily for 12 weeks reduced waist circumference more than placebo.Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized,…
- In 60 adults with severe COPD, 80 mg of nanocurcumin for 3 months lowered IL-6 and improved breathing tests, but weight and BMI rose more than with placebo.Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placeb…
- In 60 adults with type 2 diabetes taking glimepiride, 1100 mg of curcumin daily for 3 months did not change weight compared with placebo, though it lowered cholesterol and inflammation markers.Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled tr…
- In 60 patients with abnormal blood fats, cynarin for 50 days lowered cholesterol and body weight compared with placebo.[Controlled application of cynarin in the treatment of hyperlipemic syndrome. Observations in 60 cases].
- In 60 overweight adults with mild high cholesterol, 100 mg of artichoke extract with bergamot for 2 months reduced waist size and visceral fat more than placebo.Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia.
- In 60 people with moderately high cholesterol, a daily combination supplement with artichoke for 8 weeks reduced waist circumference more than placebo.Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of No…
- In 60 adults with high cholesterol, a red yeast rice and artichoke supplement for 8 weeks lowered body mass index by 2.1% along with improving cholesterol.Three arms, double-blind, non-inferiority, randomized clinical study testing the lipid-lowering effect of a novel dietar…
- In a placebo-controlled trial of 59 adults with type 2 diabetes on glibenclamide, 200 mg of silymarin daily for 120 days improved long-term and after-meal blood sugar control and reduced body mass index compared with placebo.Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass inde…
- In 58 adults with inflammatory bowel disease, 1000 mg of curcumin with piperine daily for 12 weeks increased muscle mass and improved body composition compared with placebo; body weight was not reported as a result.Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind,…
- In 57 adults with Hashimoto's thyroiditis, 1320 mg of curcumin daily with an anti-inflammatory diet for 12 weeks did not produce significant between-group differences in waist circumference or waist-to-hip ratio compared with placebo, though both groups shrank in waist size.The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in …
- In 56 teenagers with obesity and insulin resistance (50 finished), 3 months of zinc gluconate 5 mg plus myo-inositol improved HDL cholesterol but not the main insulin resistance measure compared with placebo, though insulin and insulin resistance were lower in those with severe obesity in a follow-up analysis.Efficacy of myo-inositol and zinc on insulin resistance in a paediatric population with obesity.
- In 55 overweight adults with raised fasting blood sugar, 600 mg a day of artichoke extract for 8 weeks improved blood sugar, insulin resistance and blood fats compared with placebo, but the abstract reports no significant weight difference between groups.Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extr…
- In 50 overweight or obese people with fatty liver disease on an energy-restricted diet, 30 mg of zinc daily for 8 weeks lowered weight, body mass index and waist size more than placebo.The effects of zinc supplementation on the metabolic factors in patients with non-alcoholic fatty liver disease: a rando…
- In 50 pre-obese adults, 150 mg a day of an artichoke-based supplement for six months reduced body weight, blood sugar and cholesterol, and improved liver function and blood vessel health.A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesit…
- In 48 women with rheumatoid arthritis, 500 mg of curcumin daily for 8 weeks lowered weight, BMI and waist size compared with placebo, along with inflammation markers.Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheum…
- In 46 adults with fatty liver disease, 3000 mg of turmeric powder daily for 12 weeks lowered blood sugar, insulin, and leptin more than placebo, but did not significantly change body weight or body mass index.Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Dise…
- In 45 adults with fatty liver disease, 250 mg of phytosomal curcumin daily for 8 weeks lowered weight, waist circumference, body mass index and body fat percent more than placebo, and also reduced the DNA damage marker 8-OHdG.Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease.
- In overweight adults with metabolic syndrome, 60 days of bioavailable curcumin increased weight loss, body fat reduction and waistline reduction compared with phosphatidylserine alone.Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a random…
- In 44 adults with fatty liver disease, 250 mg of phytosomal curcumin daily for 8 weeks lowered body mass index compared with placebo, but other body measures and DNA damage markers did not differ significantly.A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liv…
- In 41 adults with overweight or obesity (16 men, 25 women) doing alternate-day fasting for 8 weeks, krill oil containing choline (about 312 mg choline per day) did not change weight loss compared with placebo (about 4.6 kg vs 4.5 kg), though it reduced loss of fat-free mass and grip strength.Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized T…
- In a placebo-controlled trial of 40 adults with type 2 diabetes, 140 mg of milk thistle extract three times daily for 45 days raised antioxidant enzymes, lowered a marker of inflammation by about 27% and reduced oxidative stress compared with placebo, with no side effects reported.Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patient…
- In 40 hemodialysis patients with kidney disease, 500 mg of curcumin plus 500 mg of resveratrol daily for 12 weeks improved BMI, muscle and bone mass compared with placebo.Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Co…
- In 40 patients with high blood pressure taking captopril, 500 mg of artichoke twice daily for 8 weeks improved body mass index compared with placebo.The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Co…
- In 40 people awaiting weight-loss surgery, artichoke leaf extract for 6 weeks reduced liver fat and liver size and lowered body fat percentage compared with placebo, though liver enzyme levels rose.Artichoke leaf extract reduces steatosis and decreases liver size in prebariatric patients: A randomized placebo-control…
- In a placebo-controlled trial of 39 overweight adults over 2 months, a combined bean and artichoke extract increased fullness and significantly reduced body mass index in the supplement group, while the placebo group did not change.Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized ex…
- In 36 overweight or obese people, 2.8 g a day of freeze-dried red beet leaves for four weeks lowered body weight and BMI, but the control group did the same, while LDL cholesterol fell only in the beet leaf group.Effect of Freeze-Dried Red Beet (Beta vulgaris L.) Leaf Supplementation on Biochemical and Anthropometrical Parameters i…
- In 35 Brazilian women with high waist circumference, 500 mg of curcumin daily for 90 days reduced body mass and blood sugar and lipids compared with placebo, but other body measurements did not change.Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a rand…
- In adults with impaired glucose tolerance or type 2 diabetes, 180 mg daily of highly absorbable curcumin for six months did not significantly change HbA1c compared with placebo, though body mass index change tended to be greater.Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mel…
- In 33 adults with cancer-related wasting, 1600 mg of curcumin daily for 8 weeks did not change body weight, body fat, or muscle mass compared with placebo.A Double-Blind, Placebo-Controlled Randomized Phase IIa Study: Evaluating the Effect of Curcumin for Treatment of Cancer…
- In 31 women with severe obesity before bariatric surgery, 1500 mg of curcumin daily for 13 weeks lowered BMI and neck size compared with placebo.Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Pl…
- In a 30-person pilot trial of gastrointestinal cancer patients before surgery, a curcumin-containing immunonutrient formula for 10 to 14 days produced greater weight gain and lower CRP inflammation than a standard formula, with the weight gain being the opposite of weight loss.Novel immune-modulating formula versus standard formula for gastrointestinal cancer patients at risk of malnutrition und…
- In 29 overweight adults on calorie restriction for 14 days, adding beetroot juice did not change body composition or energy expenditure compared with calorie restriction alone, though blood vessel function and a cognitive test score improved more.Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves …
- In 28 older adults with prediabetes, 80 mg of curcumin daily for 12 weeks lowered HbA1c but did not change BMI or body weight compared with placebo.Twelve-Week Curcumin Supplementation Improves Glucose Homeostasis and Gut Health in Prediabetic Older Adults: A Pilot, D…
- In 24 adults with metabolic syndrome (13 women, 11 men) on a plant-based diet, eating two eggs daily for 4 weeks led to lower body weight and higher blood choline than an egg substitute breakfast, in a crossover trial; results were not reported separately for men.Eggs Improve Plasma Biomarkers in Patients with Metabolic Syndrome Following a Plant-Based Diet-A Randomized Crossover S…
- In a small pilot of 22 young adults taking a nutraceutical supplement for 90 days, body mass index, waist-to-height ratio and waist circumference decreased, and sleep quality scores improved.Nutraceutical composition (yeast β-glucan, prebiotics, minerals, and silymarin) predicts improvement of sleep quality an…
- In 15 prediabetic adults, two weeks of a beetroot-containing food during weight loss did not produce a clear change in gut bacteria, because individual differences were much larger than any treatment effect.Effect of Different Functional Food Supplements on the Gut Microbiota of Prediabetic Indonesian Individuals during Weigh…
- In 13 older adults with type 2 diabetes, 140 ml a day of beetroot juice for 14 days did not change brown fat fraction or activation compared with placebo.The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-B…
- Over 180 days, overweight or obese Brazilian adults taking a silymarin-containing nutraceutical blend had improved gut bacteria, cytokine levels and anthropometric measures.Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian …
- In a double-blind trial of elderly women with metabolic syndrome (not men), burdock root extract prevented the waist increase seen in the control group and raised some sex hormones, but combining it with aquatic exercise added no extra benefit.Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones i…
- In 59 sedentary adults with overweight or obesity taking a supplement with silymarin for 90 to 180 days, waist measurements and waist-to-height ratio decreased slightly, without any change in diet.Novel nutraceutical supplements with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate o…
- In a randomized pilot of 36 adults with fatty liver disease, silymarin plus vitamin E with a low-calorie diet and exercise for 3 months improved liver enzyme and fatty liver scores more than diet alone, and both groups lost weight.Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study…
- In a controlled trial of growth-delayed teenagers aged 14 to 19 with sickle cell anemia, zinc supplementation significantly improved height growth and body weight.Zinc in sickle cell disease.
- In teenagers with sickle cell anemia who were growing slowly, zinc supplementation improved growth and body weight compared with the control group.Zinc deficiency in sickle cell disease.
- In 153 adults with muscle and joint disease, a six-week topical herbal treatment containing turmeric lowered body weight along with pain and muscle markers, but the study had no placebo group.Management of muscular dystrophy during osteoarthritis disorder: A topical phytotherapeutic treatment protocol.
- In 78 adults with metabolic syndrome, 45 of them men, taking a multi-herb supplement containing silymarin for 4 months, body weight and waist circumference decreased, though there was no control group.Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrom…
- In a 21-day pre-post program without a control group, 49 adults (13 of them men) ate a low-calorie vegan diet and took a supplement cleanse that included chanca piedra; the group lost weight and lowered total and low-density lipoprotein cholesterol, and testosterone rose in men, but the abstract does not separate chanca piedra's effect from the diet and other supplements.Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients pa…
- In an open-label study of 30 adults with advanced type 2 diabetes already taking standard medicines, one sachet of a six-herb blend containing milk thistle twice daily for 40 days lowered fasting blood sugar, HbA1c, LDL cholesterol and triglycerides, with only mild nausea or diarrhea in a few people.Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with ad…
- In over 5,600 adults with metabolic syndrome and overweight, the largest one-year increase in dietary choline or betaine was linked with a 2.9 kg greater reduction in body weight and a 3.4 cm smaller waist over one year.One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in …
- In 43 adults with high-normal blood pressure, about 14 weeks of lifestyle advice plus a 500 mg daily beetroot extract lowered blood pressure, but body weight did not change significantly.The Effects of ESC/ESH-Based Written Generic Lifestyle Advice and a Nutraceutical on 24-Hour Blood Pressure in Patients …
- In four men placed on a mild zinc-restricted diet for several weeks, all lost weight, showing that a zinc-deficient state itself caused weight loss rather than weight control.Experimental zinc deficiency in humans.
- An integrative review of mostly observational studies found that zinc and body composition are generally linked, and that zinc metabolism is disrupted in people with obesity, though the mechanisms remain unclear.Association between zinc and body composition: An integrative review.
- In a pilot study of overweight adults taking LL1 capsules containing silymarin for 180 days, gut bacteria, sleep, mood, cytokine levels and body measurements improved, though the silymarin amount and group sizes were not stated.Nutraceutical Capsules LL1 and Silymarin Supplementation Act on Mood and Sleep Quality Perception by Microbiota-Gut-Brai…
- In a mouse study, mothers given choline during a high-fat diet had male offspring with better blood sugar control after six weeks of high-fat feeding, while female offspring showed minimal effects; this was not a human study and weight was not reported as improved.Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offsprin…
- In a mouse study, sea cucumber ether-phospholipids given at 150 mg per kg of body weight for eight weeks reduced liver fat buildup and boosted autophagy in the brain's hypothalamus in mice fed a high-fat diet; this was not a human study.Sea cucumber ether-phospholipids improve hepatic steatosis and enhance hypothalamic autophagy in high-fat diet-fed mice.
- In mice fed a high-fat diet, an extract of burdock fruit reduced weight gain and fat tissue mass and improved blood fats. This was an animal and cell study, not a human trial.Anti-obesity effects of Arctii Fructus (Arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice.
- In a mouse study of cancer-related wasting, an extract of burdock fruit prevented weight loss of muscle and fat tissue and lowered mortality. This was an animal and cell study, not a human trial.The Extract of Arctium lappa L. Fruit (Arctii Fructus) Improves Cancer-Induced Cachexia by Inhibiting Weight Loss of Ske…
- In a rat study, an alcohol-based extract of burdock root slowed weight gain and reduced fat in the liver in rats fed a high-sugar, high-fat diet. This was an animal study, not a human trial.Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK/…
- In a mouse study, arctigenin from burdock reduced weight gain, fat buildup and liver damage in mice fed a high-fat diet, partly by changing gut bacteria. This was an animal study, not a human trial.Arctigenin ameliorates high-fat diet-induced metabolic disorders by reshaping gut microbiota and modulating GPR/HDAC3 an…
- In rats, Phyllanthus amarus leaf and seed water extract at 150 to 600 mg per kg per day reduced body weight and blood sugar in normal rats and dose-dependently blocked weight gain and blood sugar rises in rats given a sucrose drink; this was an animal study.The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal stud…
- In a study of obese diabetic rats, the highest tested dose of Phyllanthus niruri extract moved metabolic disorders toward normal, lowered blood sugar, and improved blood fats; this was an animal study and did not measure weight loss directly.Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract.
- In obese rats fed a high-fat diet, Phyllanthus niruri extract packaged in fat-based nanocarriers reduced body weight, fatty liver, and liver inflammation, and improved insulin sensitivity and blood fats; this was an animal study.Phyllanthus niruri niosomes ameliorate obesity-induced hepatic steatosis in rats via modulating MALAT1/miR-206/GLP-1R si…
Review Totals and Summary
Members Only18 reviews · 93% positive
Customer feedback on Black Forest comes mostly from reviews of its cocoa flavanol powder. Those reviews are overwhelmingly positive about taste. Buyers call it delicious and a "cozy" evening treat. Many mix it into coffee or coconut milk, and one reviewer on Walmart called it a morning "rocket fuel." Older and male buyers often describe feeling better. Examples include steadier blood pressure, more energy, and being able to keep up with gym sessions and play with grandchildren. One reviewer called the products a game changer for men over 40. Some customers also say the cocoa is better than other brands they've tried. Published feedback on the NMN, Turkesterone, and Tongkat Ali products is thinner, but they are marketed on purity, third-party testing, and BioPerine for absorption. Bloggers who tried the NMN liked that it is shelf-stable and needs no refrigeration. The criticism is milder and falls into a few groups. One customer asked why the cocoa comes in black plastic and whether the container is safe. Some low star ratings, such as a 2-out-of-5 on Walmart, show that not everyone notices a benefit. Skeptical analysts say the brand's heart and performance claims go beyond what the evidence supports. For example, they point out that the COSMOS cocoa trial was inconclusive on cardiovascular events. They also say the testosterone and muscle claims for Turkesterone and Tongkat Ali rest on limited human data. Some third-party sites raise concerns about the company itself. One critical review cites complaints about its reliability. A scam-detector site gives the website a low trust score, while ScamAdviser rates it as probably legit. Taken together, buyers like the flavor and the way they feel, while skeptics question the evidence and the company's trustworthiness.
Biohacker Summary
Members Only0 of 10 recommend it
Zinc is the main ingredient, and all ten panelists spoke about it, with most recommending or using it. They take it for immune support, testosterone and male fertility, gut lining (in the form of zinc carnosine), wound healing, mood, and skin care. Doses ranged from 15 mg a day for longevity, to 30 mg for sperm health, to 40 to 60 mg a day for fighting viruses, and one panelist uses 30 grams a day around surgery as part of his own formulation. They pair it with vitamin C, magnesium, and zinc rich foods like pumpkin seeds and oysters, and one panelist noted it raises testosterone only when zinc or testosterone levels are low. Turmeric is a smaller ingredient in this product, and one panelist warns that it should be stopped before surgery.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Zinc · recommends
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Dr. Eric Berg recommends pairing turmeric with black pepper to improve curcumin absorption.
- States that one cup of turmeric water could have surprising benefits for health.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
- Notes that birth control pills deplete the body of zinc, which is needed for the brain to make serotonin.
- Added zinc to his creatine product because a deficiency in zinc might make creatine not work as well.
- Mentions that grass-fed liver is loaded with zinc.
- Recommends zinc to enhance testosterone.
- Highly recommends taking at least 50 mg of zinc at the first sign of a cold.
- Dr. Eric Berg recommends adding turmeric to eggs to support satiety, antioxidant potential, cardiovascular, and liver health.
- Mentions that egg yolks contain choline, which helps the brain and prevents a fatty liver.
- Recommends a new product called black elderberry with added zinc and vitamin D, which combines four essential immune support nutrients, and advises taking three per day with meals.
- Notes that choline is a key nutrient many people are deficient in, helping repair membranes, reduce breakouts, improve skin texture, and lift brain fog by being a building block for acetylcholine, which aids memory, focus, and concentration.
Andrew Huberman · Zinc · uses
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Recommends choline-rich foods to enhance focus and acetylcholine.
- Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
- Notes that choline can be converted into TMAO, similar to L-carnitine, and suggests measuring TMAO levels if supplementing with it.
- Recommends avoiding bioavailable curcuminoids like bioavailable turmeric if someone's DHT is already low or if they have somewhat insensitive androgen receptors.
Ben Greenfield · Zinc · warns
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Advises patients to stop turmeric before surgery because it can act as a med or antiplatelet agent.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
- Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
- Warns that he was taking so much zinc without realizing it because it was in five different things he was taking, and he couldn't pinpoint the problem.
- Recommends taking beetroot, a pre-workout that vasodilates, about 30 minutes before a sauna session to induce more sweating and aid in detoxification.
- Recommends supplementing with zinc if deficient, as multiple trials show significant symptom reduction of tinnitus in zinc-deficient individuals.
- Notes a new study indicating that zinc is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Recommends using hormone building blocks like zinc for hormone optimization.
- Recommends root spices like turmeric for use on the AIP diet.
- Recommends taking a milk thistle supplement standardized to 70-140mg silymarin 30-60 minutes before hot-cold contrast therapy.
Thomas DeLauer · Zinc · uses
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recently started taking turmeric for their joints, specifically for knee issues, as it helps support recovery, especially after a workout.
- Mentions that Dose Daily contains turmeric, which contributes to its positive impact on liver enzyme levels.
- Notes that Dose Daily contains organic milk thistle, highlighting its significant data supporting liver health benefits.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
- Compares zinc content, noting salmon has under 1mg while oysters have 74mg per 100g, a 70x difference.
- Recommends keeping zinc levels topped off because it is a critical cofactor for over 300 enzymes and is important for immune cells, testosterone, and wound healing.
- Says he feels really good when he takes milk thistle, usually for about a week, and notes it is effective.
- Recommends 15 mg of supplemental zinc if oysters are not realistic, but emphasizes that food source zinc is better as it comes with natural cofactors like copper and selenium.
- Recommends Milk thistle, specifically 200-400mg of silymarin at 80%, for decent reductions in ALT and AST and higher antioxidant enzyme activity.
- Recommends milk thistle for liver health, explaining that silymarin lowers MDA and raises antioxidant enzymes.
- Recommends getting zinc, along with vitamin D, magnesium, and calcium, from foods like sardines, as they are important for inflammatory pathways in the gut.
Dave Asprey · Zinc · uses
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
- Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
- Dave explains how to stack racetams with choline for smarter cognitive enhancement.
- Recommends taking choline donors, especially if over 35, to prevent headaches and muscle tension that can occur when taking racetams due to increased demand on the acetylcholine system.
- Advises that if someone has a goal, they should probably do simple things like getting more zinc if it helps their goal before using peptides.
- Recommends zinc for muscle and bone formation, stating that without it, the body cannot effectively build muscle and bone even with exercise and protein intake.
- Warns that turmeric is exceptionally high in oxalate, which can cause issues if consumed in large amounts.
- Uses turmeric as an example of an unprotected ingredient that, once proven beneficial through studies, allows everyone to take advantage of the knowledge.
- Dave Asprey mentions zinc as a supplement and cofactor that supports thyroid activation.
- Recommends zinc as a cofactor that can help thyroid function, especially with conversion issues.
- Argues that if you are lacking zinc, ESS60 will not work as well.
Dr. Mark Hyman · Zinc · uses
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Recommends correcting nutrient deficiencies with zinc.
- Recommends nutrient-dense foods rich in zinc, such as pumpkin seeds and oysters, to reduce inflammation.
- Recommends turmeric as an anti-inflammatory powerhouse.
- Notes that if people have used something like turmeric for several thousand years as a remedy and an anti-inflammatory compound, it can't be wrong.
- Used zinc as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- Notes that zinc supports immune health, helps wounds heal, and plays a key role in growth and tissue repair, and they measure it.
- Mentions zinc is needed for phase one liver functions and inflammation.
- States he was using circ turmeric to stimulate the NRF2 pathway and open up detox.
- Notes that birth control drains zinc.
- Recommends zinc for immune system support and modulation.
- Recommends milk thistle for detoxification support.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
Dr. Rhonda Patrick · Zinc · recommends
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- Likes adding turmeric to bone broth for flavor, warmth, and its anti-inflammatory compounds.
- States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
- Recommends nutrients like zinc for men to prioritize sperm mitochondrial health.
- Choline plays a critical role in fetal brain development, and the form and dose matter. Pregnant women who supplemented with twice the RDA for choline (900 mg/day) had children with higher intelligence scores than women taking 450 mg/day.
- Recommends that pregnant women supplement with choline, specifically phosphatidylcholine, to potentially have smarter babies, citing a randomized controlled trial where mothers who nearly doubled their choline intake had children who scored higher on IQ and cognitive tests.
- Recommends Zinc, stating it is a critical mineral required for testosterone production and that supplementation corrects deficiency-related low testosterone.
- Recommends correcting deficiencies in zinc to directly increase total testosterone by up to 100+ ng/dL.
- Recommends focusing on zinc to optimize testosterone and hormone health generally, noting that it supports luteinizing hormone production, which stimulates testosterone synthesis and conversion to dihydrotestosterone.
- Recommends zinc as one of the most reliable natural supplements for boosting testosterone if one is deficient, noting it's part of the ZMA combination.
- Discusses which choline supplement won't raise TMAO.
- Recommends beetroot powder, specifically NOW brand beetroot extract, for immediately enhancing cognitive performance by increasing blood flow to the brain.
Siim Land · Zinc · recommends
- States that deficiencies in nutrients such as zinc can impair normal immune regulation.
- States that beetroot is one of the boring foods from which he gets most of his fiber.
- Recommends beetroot for heart health.
- Includes beetroot powder in their supplement stack.
- Explains that zinc raises testosterone only if zinc status or testosterone levels are low, and can reduce the duration and severity of colds and flu, and lower blood sugar and lipids if zinc status is low.
- Mentions that turmeric helps with arthritis and joint pain, with clinical trials showing its effectiveness.
- States that fixing zinc deficiency can double testosterone if low testosterone is due to zinc deficiency.
- States that zinc has strong evidence for increasing testosterone, but only if one has low zinc status.
- States that zinc deficiency is observed in children with premature graying of hair.
- Tried milk thistle for improving liver health based on research, but it didn't do anything for him.
- Warns that supplementing 250 mg of zinc sulfate, which provides 55 to 60 mg of elemental zinc, is above the tolerable upper limit and can cause side effects like reduced copper absorption, anemia, immune dysfunction, GI stress, abdominal pain, diarrhea, and a metallic taste.
- States that zinc helps with immunity, wound healing, and testosterone levels, acknowledging its importance as a mineral and placing it in the 'good tier' despite not personally finding much value from it.
- Places Turmeric or Curcumin in the 'god tier' due to numerous human clinical trials for inflammation, noting that its poor bioavailability means supplements should ideally be liposomal formulations or include piperine (black pepper) to enhance absorption.
- States that turmeric is known for its anti-inflammatory effects, lowering inflammation markers like CRP in clinical trials.
Bryan Johnson · Zinc · uses
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 15 mg of Zinc in the morning.
- Takes 15 mg of Zinc in the morning for longevity.
- Uses turmeric for its antioxidant, anti-inflammatory, and metabolic benefits, noting that black pepper boosts its power.
- Bryan Johnson's baseline measurements showed low zinc, which was easy to fix by adjusting her protocol and supplements.
- Takes one gram of turmeric a day for inflammation, joints, and liver.
- Recommends adequate Zinc for hair health, noting it is in the Blueprint stack.
Peter Attia · Zinc · recommends
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter Attia's brand, AVIA Skincare, incorporates Ayurvedic wisdom, including turmeric and other Eastern botanicals, for anti-inflammatory care.
- Mentions that beetroot concentrate is rich in nitrates, which the body converts into nitric oxide, helping with vasodilation and potentially boosting VO2 Max by about 5% in amateur athletes.
- Discusses beetroot concentrates as a source of nitrate that the body converts to nitric oxide, which helps with vasodilation and can positively affect VO2 max in amateur athletes, but not in elite athletes.
- Discusses beetroot concentrates, which are rich in nitrates, and how the body converts these to nitric oxide, aiding vasodilation and blood circulation. He notes that while it has a positive effect on V2 Max in amateur athletes, it's hard to reproduce in elite athletes.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- States that for choline deficiencies, which are sometimes measurable and seen in people post-bariatric surgery, they are not terribly aware of any downsides to taking choline supplements, but cautions about quantifying what's in supplements.
- Explains that for Wilson's syndrome, which can lead to liver failure, the treatment given to children is zinc, which is inexpensive and effective in outcompeting copper to prevent overload.
- Uses a new irrigant called ZinC and Gent because they are very worried about prosthetic infection.
- Discusses the AREDS formula, which includes C, E, beta-carotene, zinc, and copper, and later lutein and zeaxanthin instead of beta-carotene. Studies showed it could delay or reduce the conversion of mild to severe macular degeneration but had no effect on severe disease or preventing it in healthy individuals.
- Mentions that a survey of doctors showed they recommend Zinc for COVID-19, but notes there is no real evidence behind it.
- Mentions zinc pyrithione as a treatment protocol for dandruff, which addresses malassezia yeast overgrowth in the scalp.
- Peter Atia asks Chris Masterjohn about the required choline dose for a patient with non-alcoholic fatty liver disease, and Chris guesses around 1200 milligrams, which would be difficult to achieve through food alone.
RAL Summary
Members OnlyTier 4 for Weight and Metabolism for Men
The review summary describes Black Forest's cocoa flavanol powder, NMN, Turkesterone and Tongkat Ali products and the company in general, not THE PROTOCOL liver and weight formula, so it should be set aside. Its reviews are set aside, so it is graded on its studies alone. Human studies support Zinc (3 of 10 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
Take 2 servings a day (4 capsules) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 33 of the 117 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Metabolic system, Digestive system, Liver
Combine with: If the goal is gallbladder support and fat digestion, pair it with proven ingredients: ox bile or purified bile salts with meals to emulsify fats, taurine and phosphatidylcholine or lecithin to support bile fluidity, and a broad-spectrum digestive enzyme with lipase. Choleretic herbs such as artichoke leaf extract, dandelion root, and milk thistle support bile flow and liver function. Magnesium can ease sluggish bowel transit that often accompanies poor fat digestion. Eat smaller, moderate-fat meals, and see a clinician first if you have gallstones, a bile duct obstruction, or persistent right upper abdominal pain, because bile stimulants can be harmful in those cases.
Possible side effects: No major side effects reported.
Supplement Facts
Choline 12 mg · Zinc 30 mg · Milk Thistle Seed Extract 200 mg
| Choline | 12 mg | |
| Zinc | 30 mg | |
| Milk Thistle Seed Extract | 200 mg | † |
| Organic Turmeric Root | 60 mg | † |
| Organic Burdock Root | 60 mg | † |
| Organic Beet Root Juice Powder | 50 mg | † |
| Artichoke Leaf Extract | 50 mg | † |
| Chanca Piedra Extract | 50 mg | † |
| Dandelion Root | 50 mg | † |
| Proprietary Blend | 416 mg | † |
Other ingredients: Hypromellose (Capsule), Silicon Dioxide, Rice Flour.
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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