California Gold Nutrition GLP-1 Supreme Review
A dietary supplement designed to support metabolic health and weight management, featuring key ingredients like Akkermansia, Berberine, Quercetin, and Curcumin.
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Study, Trial or Testing Result Summary
Members Only152 human studies · 67 improved
Curcumin, at a full dose here, has the strongest support. A review of 103 trials with 7,216 people found it lowered body weight [1], and a review of 111 trials found about 0.8 kilograms more loss than placebo [2]. In seven trials of 447 women with polycystic ovary syndrome, body mass index dropped slightly [3]. Chromium is at a full dose when taken three times a day, but in women it mostly did not help weight [4][5]. Akkermansia, at an unclear dose, led to less weight regain after dieting in one trial [6], but showed no overall weight difference in another [7]. Dihydroberberine is below the studied dose, and no study tested it directly. Its parent compound, berberine, gave modest weight loss in some reviews [8] but not in others [9]. Cinnamon is well below the studied dose. Reviews found about 1 kilogram of weight loss at much higher amounts [10]. Quercetin, at an unclear dose, has too little human evidence; one small trial found no clear change in waist size [11]. Animal and cell studies are never counted.
See all 152 studies →Hide the studies
- Across 103 placebo-controlled trials with 7216 people, curcumin lowered body weight (high-certainty evidence), along with blood sugar, inflammation and fats in the blood.Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.
- In a pooled analysis of 111 trials in adults with overweight or obesity, curcumin led to a small weight loss of about 0.8 kg compared with placebo, with moderate certainty.Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and netwo…
- In 79 trials of 5,501 women with polycystic ovary syndrome, carnitine was the best option for obesity while chromium helped lipid levels, follicle-stimulating hormone and antioxidant capacity rather than weight.The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and ne…
- In 41 trials of 2,362 women with polycystic ovary syndrome, chromium did not reduce body weight or BMI (carnitine, inositol and probiotics did), though chromium did lower fasting insulin and triglycerides.Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary synd…
- In trials of plant compounds in 2173 people with fatty liver disease, curcumin lowered BMI, liver enzymes, blood fats and insulin resistance compared with placebo, without more side effects.Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A syste…
- In 21 trials of 1,316 people with overweight or obesity, chromium led to a small average loss of 0.75 kg and 0.68% body fat, mainly in studies of 12 weeks or less and doses of 400 mcg a day or less; clinical importance is uncertain.A meta-analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesi…
- In 11 trials with 876 people (53% women), curcumin lowered body weight by about 1.1 kg and BMI by about 0.5, but did not significantly change waist size overall.The effects of curcumin supplementation on body weight, body mass index and waist circumference: a systematic review and…
- Across 12 trials with 849 adults, berberine and barberry did not significantly change body weight, body mass index or waist size, though waist-to-hip ratio fell.Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized contro…
- In 10 trials with 811 people with fatty liver disease, berberine lowered body mass index along with liver enzymes, cholesterol and insulin resistance, with only mild stomach side effects.The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and…
- Across 12 randomized trials with 786 adults, cinnamon lowered body weight by about 1 kg, body mass index by 0.5, waist size by 2.4 cm and body fat by 1%, with larger fat loss at 2 g or more per day for 12 weeks or longer.Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized c…
- In nine trials of 622 overweight or obese adults, chromium picolinate (200 to 1000 mcg) cut body weight by about 1.1 kg after 12 to 16 weeks, but the evidence was low quality and the authors found no reliable basis to recommend it.Chromium picolinate supplementation for overweight or obese adults.
- In ten placebo-controlled trials (489 people), chromium picolinate led to about 1.1 kg more weight loss than placebo, but the effect depended on one trial and its clinical relevance is debatable.Chromium picolinate for reducing body weight: meta-analysis of randomized trials.
- In seven trials with 447 women with polycystic ovary syndrome, curcumin slightly lowered body mass index and also improved blood sugar, insulin resistance, cholesterol and inflammation, without more side effects.Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.
- In 3 trials with 233 people with schizophrenia and metabolic syndrome, added berberine reduced body weight, body mass index and waist size compared with controls.Adjunctive berberine for schizophrenia with metabolic syndrome: a systematic review and meta-analysis.
- Across 11 trials in overweight and obese people, chromium led to 0.5 kg more weight loss than placebo, a small effect of uncertain clinical importance with highly varied results.Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials.
- Across 7 randomized trials in women with polycystic ovary syndrome, chromium supplementation lowered body mass index, fasting insulin (in larger studies) and free testosterone, but did not change total testosterone, hair growth score or other hormones.Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.
- In 15 trials in people with type 2 diabetes, chromium at 200 to 1000 mcg a day did not significantly change BMI, though it lowered diastolic blood pressure and an oxidative stress marker.Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in pa…
- In 14 trials in people with type 2 diabetes, chromium did not significantly change body weight, BMI, waist size or fat mass.Effects of chromium supplementation on body composition in patients with type 2 diabetes: A dose-response systematic rev…
- Across 50 trials, curcumin reduced body weight by about 0.6 kg, BMI and waist size, with larger reductions (about 0.8 kg) for bioavailability-enhanced forms.The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-an…
- In seven placebo-controlled trials in people with fatty liver disease, phytosomal curcumin reduced weight by about 2 kg, body fat by about 2 percentage points, BMI and waist size.Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease: A meta-analysis.
- Across 12 trials, berberine moderately lowered body weight by about 2 kg, body mass index, waist size and C-reactive protein, but did not change liver enzymes.The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic rev…
- In 46 trials in people with type 2 diabetes, berberine lowered body mass index by about 1 point along with blood sugar, insulin resistance, blood fats and inflammation.The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Rand…
- In a pooled analysis of adult trials, berberine lowered body weight and body mass index, with the best effect on weight at about 1 gram a day, plus better blood fats, blood sugar and blood pressure.The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response…
- Across 23 trials in adults, berberine reduced body weight by about 0.9 kg, body mass index and waist size, but not waist-to-hip ratio.The effect of berberine on obesity indices: a systematic review and meta-analysis.
- In five trials of women with polycystic ovary syndrome, cinnamon did not significantly change body weight or body mass index, though it improved blood sugar, insulin and cholesterol.Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analy…
- Pooling 7 earlier meta-analyses, cinnamon reduced body weight by 0.67 kg and body mass index by 0.45 but did not significantly change waist size, with better results at 3 g or more per day and in women with polycystic ovary syndrome.Cinnamon, an effective anti-obesity agent: Evidence from an umbrella meta-analysis.
- Across 12 randomized trials in women with polycystic ovary syndrome, cinnamon lowered body weight by about 0.47 kg compared with controls, along with improvements in blood sugar, insulin resistance and cholesterol.Effect of cinnamon as a Chinese herbal medicine on markers of cardiovascular risk in women with polycystic ovary syndrom…
- In 34 trials of 2580 people having cancer treatment, curcumin gave mixed results on weight change and body composition, with some reduction in weight loss but high risk of bias.Curcumin as a complementary treatment in oncological therapy: a systematic review.
- A review of randomized double-blind trials of weight-loss supplements, including chromium picolinate, found some encouraging data but no convincing proof that any supplement reduces body weight.Dietary supplements for body-weight reduction: a systematic review.
- In a review of 6 trials in women with polycystic ovary syndrome, two studies found chromium had no effect on weight or body mass index and one found weight loss, so overall effects on weight, glucose, lipids and hormones were limited.Chromium supplementation does not improve weight loss or metabolic and hormonal variables in patients with polycystic ov…
- Across eight randomized trials in adults, five using regular curcumin over short periods showed no effect on body measures, while three using a more absorbable form or longer duration showed benefit on weight.Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials.
- In five trials of women with polycystic ovary syndrome, curcumin supplements improved blood fats, blood sugar, body mass index and lowered male hormone levels.Complementary administration of curcumin in PCOS: a systematic review.
- In women with polycystic ovary syndrome, berberine did not significantly reduce body weight and results for waist size and body mass index conflicted, but waist-to-hip ratio and insulin resistance improved.The effect and safety of Berberine on polycystic ovary syndrome: a systematic review.
- A review of 54 systematic reviews found berberine improved about 57% (4 of 7) of obesity outcomes and most outcomes for other conditions, but the underlying reviews were mostly of low or very low quality.Berberine and health outcomes: an overview of systematic reviews.
- This review of plant-compound studies in people with metabolic syndrome found cinnamon reduced blood sugar but did not report a weight benefit, unlike green tea.Effects of dietary polyphenols on metabolic syndrome features in humans: a systematic review.
- In a review of nine studies in women with polycystic ovary syndrome, cinnamon improved cholesterol and insulin sensitivity but its effects on body weight and body mass index were inconsistent.Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review.
- An umbrella review of 21 meta-analyses found cinnamon improved blood sugar and blood fats in people with metabolic diseases, while body weight results were not clearly summarized.The effects of cinnamon on patients with metabolic diseases: an umbrella review of meta-analyses of randomized controlle…
- In 337 adults without diabetes who had obesity and fatty liver disease (about 34% women), 1 gram of berberine daily for 6 months did not reduce belly fat or liver fat compared with placebo, though it modestly lowered LDL cholesterol and a marker of inflammation.Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.
- In 272 people with type 2 diabetes, 1500 mg of curcumin daily for 12 months lowered body mass index and leptin compared with placebo, along with better blood sugar and insulin function.Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial.
- In 200 women with polycystic ovary syndrome, nanocurcumin at 80 mg three times daily for 12 weeks, combined with a med, improved body weight and BMI more than placebo or either drug alone.Read the study on PubMed (39461199) →
- In 166 men and women with metabolic syndrome risk factors doing diet and exercise for 12 weeks, chromium with Phyllanthus emblica and shilajit gave some improvements in body composition, insulin sensitivity, strength and fitness compared with placebo, mostly at 6 weeks and more with the higher dose.Effects of 12 Weeks of Chromium, Phyllanthus emblica Fruit Extract, and Shilajit Supplementation on Markers of Cardiomet…
- In 150 infertile women with polycystic ovary syndrome, 3 months of berberine before IVF improved hormone and blood sugar measures versus placebo, and lowered body mass index more than a med did.The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment.
- In 144 people at low heart risk, berberine 500 mg twice daily for 3 months improved cholesterol versus placebo, but weight loss was reported only after the diet run-in period, not as a berberine effect.Effects of berberine on lipid profile in subjects with low cardiovascular risk.
- In 140 people with type 2 diabetes, 1,000 mg of cinnamon bark powder daily for 3 months improved body mass index, body fat and belly fat versus placebo, with larger changes in those with a body mass index of 27 or more.Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial.
- In 140 adults with type 2 diabetes (mostly women), 3 g a day of cinnamon for 90 days lowered weight, BMI and waist slightly, but the changes were not statistically significant compared with placebo.Efficacy of cinnamon in reducing anthropometric measurements in individuals with type 2 diabetes: a clinical trial.
- In 136 adults with type 2 diabetes and obesity, a berberine and silymarin combination taken for 52 weeks reduced body fat measured by bioimpedance, waist size and body mass index compared with placebo.Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week dou…
- In 131 adults with pre-hypertension, a once-daily multi-ingredient supplement containing berberine, added to diet for 3 months, lowered cholesterol and glucose more than diet alone, but body mass index did not change.The Effects of a New Generation of Nutraceutical Compounds on Lipid Profile and Glycaemia in Subjects with Pre-hypertens…
- In 116 adults with metabolic syndrome, 3 g a day of cinnamon for 16 weeks reduced waist size and BMI significantly more than placebo, along with better blood sugar, blood pressure and cholesterol.Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome:…
- In 113 adults with atypical depression, 600 mcg of chromium picolinate daily for 8 weeks did not improve overall depression scores more than placebo, but it reduced carbohydrate cravings and increased eating and appetite more than placebo.A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydr…
- In a 12-week placebo-controlled trial of 105 overweight adults, a botanical tablet formula containing chromium yeast did not change body weight versus placebo but produced greater body fat loss and a better body composition score, though chromium's own contribution cannot be separated from the other ingredients.Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition a…
- In 105 people with type 2 diabetes, 1 g a day of cinnamon for 90 days led to a significantly lower BMI than placebo, though blood sugar and cholesterol did not differ between groups.Controlling type 2 diabetes mellitus with herbal medicines: A triple-blind randomized clinical trial of efficacy and saf…
- In adults with fatty liver disease, 1000 mg daily phytosomal curcumin for 8 weeks lowered BMI and waist size more than placebo.Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.
- In 102 adults with mildly high cholesterol, a multi-ingredient supplement containing berberine taken for 12 weeks produced an average weight loss of about 0.9 kg compared with placebo, along with lower cholesterol.Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population wit…
- In a placebo-controlled trial of 100 people with fatty liver disease and diabetes, 2000 mg per day of berberine ursodeoxycholate for 18 weeks reduced liver fat more than placebo and also produced significant weight loss.A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alc…
- In 97 adults with mild high cholesterol, 900 mg per day of berberine capsules for 3 months improved blood lipids compared with placebo, but the abstract does not report a weight or body mass index difference.[Therapeutic Effects of Berberine Capsule on Patients with Mild Hyperlipidemia].
- In 93 adults with obesity, 1000 mg of berberine per day, taken as part of a combination product for 12 weeks, reduced body weight index, total body fat and visceral fat compared with placebo.Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in …
- In 92 adults with fatty liver disease, 3 grams of turmeric daily for 12 weeks, alone or with chicory seed, reduced body mass index and waist size compared with placebo.Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver dise…
- In 90 overweight adults aged 50 to 69, a turmeric extract taken for 12 weeks lowered body weight and BMI compared with placebo and reduced inflammation markers.Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: …
- In 90 adults with overweight or obesity who had first lost weight on a low-energy diet, daily pasteurized Akkermansia for 24 weeks led to less weight regain than placebo (1.2 kg vs 3.2 kg).Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled…
- In 89 women with polycystic ovary syndrome and insulin resistance, berberine taken for 3 months reduced waist size and waist-to-hip ratio more than a med and improved blood sugar and insulin measures compared with placebo.Read the study on PubMed (22019891) →
- In 88 adults with metabolic syndrome, curcumin for 12 weeks lowered cholesterol and triglycerides but did not change body weight, body mass index, or waist size compared with placebo.Effects of curcumin and/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a rand…
- In 85 women with polycystic ovary syndrome, taking 1000 mcg of chromium picolinate daily for 6 months was associated with a significant drop in body mass index compared with the start of the study, along with improved ovulation and regular periods.Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.
- In 84 adults with prediabetes and overweight, 500 mg of curcumin daily for 90 days did not significantly change weight compared with placebo, while adding zinc with curcumin lowered body mass index compared with placebo.The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A…
- In 84 overweight or obese women with polycystic ovary syndrome, 1,500 mg a day of cinnamon for 8 weeks reduced weight significantly more than placebo, and also improved blood sugar and cholesterol.Cinnamon improves metabolic factors without detectable effects on adiponectin in women with polycystic ovary syndrome.
- In 83 women on a controlled diet, 200 mcg of chromium picolinate daily for 12 weeks did not change body weight, body fat or iron status beyond what placebo produced, though all groups lost some weight and fat.Chromium picolinate supplementation in women: effects on body weight, composition, and iron status.
- In 80 overweight adults, 1000 mcg of chromium picolinate daily for 24 weeks did not produce more weight loss than placebo, with or without nutrition education.A pilot study of chromium picolinate for weight loss.
- In 80 adults with metabolic syndrome, 1000 mg daily of curcumin for 6 weeks did not change weight, body mass index, or waist size compared with placebo.Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.
- In 80 adults with type 2 diabetes and low vitamin D, 500 mg daily of curcuminoids for 12 weeks did not produce significant differences from placebo in body measurements, though body fat measures fell within the curcumin groups.The effects of vitamin D and curcuminoids supplementation on anthropometric measurements and blood pressure in type 2 di…
- In 80 adults with fatty liver disease, 250 mg of phospholipid curcumin daily for 2 months reduced liver fat but did not produce a difference in anthropometric measures compared with placebo.The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-Blind, Ra…
- In 80 adults with fatty liver, 500 mg daily curcumin for 24 weeks reduced weight by about 2.6 kg and BMI more than placebo.Curcumin supplementation alleviates hepatic fat content associated with modulation of gut microbiota-dependent bile acid…
- In 78 adults with type 2 diabetes and fatty liver disease, 1500 mg daily of curcumin for 12 months reduced total body fat and BMI more than placebo, along with lower inflammation and oxidative stress.Curcumin for Inflammation Control in Individuals with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Stea…
- In 72 adults with diabetes and heart disease risk, curcumin taken with usual care did not change body mass index, though it lowered blood pressure, TNF-alpha and MDA compared with control.Curcumin supplementation improves the clinical outcomes of patients with diabetes and atherosclerotic cardiovascular ris…
- In 66 adults with metabolic syndrome, 500 mg of curcumin daily for 12 weeks led to significant body weight loss compared with placebo, alongside improved arterial stiffness.The Effect of Curcumin Supplementation on Pulse Wave Velocity in Patients with Metabolic Syndrome: A Randomized, Double-…
- In 66 stroke patients, 500 mg daily curcumin with piperine for 12 weeks lowered weight and waist size more than placebo, along with inflammation markers.The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients wit…
- In 66 adults with overweight or obesity, 8 weeks of yogurt with Akkermansia postbiotic reduced waist size, body fat percentage, liver enzyme and appetite scores compared with plain yogurt.Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rham…
- In 65 adults with fatty liver disease, eight weeks of phytosomal curcumin raised adiponectin and lowered leptin compared with placebo; the abstract does not report a weight change.Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver…
- In an 8-week placebo-controlled trial of 65 people with schizophrenia taking antipsychotics, 900 mg per day of berberine led to a 1.10 kg average weight loss, while the placebo group gained 1.45 kg.Berberine treatment for weight gain in patients with schizophrenia by regulating leptin rather than adiponectin.
- In 64 adults with type 2 diabetes and heart disease, 200 mcg of chromium daily for 12 weeks lowered body weight and inflammation and improved antioxidant measures compared with placebo.The Influences of Chromium Supplementation on Metabolic Status in Patients with Type 2 Diabetes Mellitus and Coronary He…
- In 63 obese adults without diabetes who had metabolic syndrome, 1000 mcg daily of chromium picolinate for 16 weeks did not change body weight, insulin sensitivity, cholesterol, or markers of inflammation and oxidative stress compared with placebo.Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.
- In a placebo-controlled trial of 62 overweight or obese adults with pre-diabetes, 4 months of a supplement with cinnamon, chromium and carnosine did not change body weight compared with placebo, though it increased fat-free mass.A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mas…
- In 60 moderately obese adults, a formula containing 4 mg niacin-bound chromium, hydroxycitric acid, and Gymnema extract reduced body weight and BMI by 5 to 6% over 8 weeks alongside a 2,000 calorie diet and walking, while placebo showed little effect; chromium's share of this result cannot be separated from the other ingredients.Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium a…
- In 60 overweight or obese adolescent girls, 500 mg daily of turmeric extract for 10 weeks showed some improvement in body mass index and waist size, but the difference from placebo was not statistically significant overall.Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial…
- In 60 oral cancer patients receiving radiation and chemotherapy, a turmeric capsule taken for 6 weeks led to less weight loss than placebo, along with fewer severe mouth sores and swallowing problems.A Randomized, Placebo-Controlled Study to Evaluate the Effect of Bio-Enhanced Turmeric Formulation on Radiation-Induced …
- In 60 adults with type 2 diabetes taking glimepiride, 1100 mg daily of curcumin for 3 months did not change body weight compared with placebo, though it lowered inflammatory marker CRP.Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled tr…
- In 59 college students in a 12-week weight training program, 200 mcg daily of chromium picolinate caused women to gain more body weight than placebo, while it had no effect on strength or body measurements in men.Effects of chromium picolinate on beginning weight training students.
- In 58 adults with mild to moderate inflammatory bowel disease, 1000 mg daily of curcumin plus piperine for 12 weeks increased fat-free mass and reduced muscle depletion compared with placebo.Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind,…
- In 58 people with overweight or obesity and type 2 diabetes, 12 weeks of Akkermansia did not change weight differently from placebo overall, though those with low starting Akkermansia levels lost weight and fat mass.Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its basel…
- In 58 adults with type 2 diabetes, 2 grams of cinnamon daily for 12 weeks lowered the three-month blood sugar average and blood pressure more than placebo, but changes in fasting blood sugar, waist size and body mass index were not significantly different from placebo.Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: …
- In 57 overweight adults, a multifaceted program combining diet advice with fibre, probiotic and chromium supplements lowered body weight by about 5 kg and body fat within 4 weeks, while the placebo group showed no notable change; the chromium dose was not separated from the fibre effects.A multifaceted lifestyle program for weight loss in overweight adults: evidence from a randomised clinical trial.
- In 57 people with Hashimoto's thyroiditis, adding 1320 mg daily of curcumin to an anti-inflammatory diet for 12 weeks produced waist reductions that were not significantly different from placebo plus the same diet.The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in …
- In a 90-day placebo-controlled trial of 56 adults with type 2 diabetes, 50 or 200 mcg of chromium nicotinate daily did not change body fat percentage or lean mass compared with placebo.Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blin…
- In 56 non-obese adults, 24 weeks of a daily 10-supplement combination including 900 mg curcumin did not change body fat or other metabolic measures.Multiple dietary supplements do not affect metabolic and cardio-vascular health.
- In 54 overweight women with polycystic ovary syndrome, 200 mcg of chromium picolinate plus 1000 mg carnitine daily for 12 weeks lowered body weight more than placebo.Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women…
- In 52 adults with fatty liver disease, 1500 mg daily of curcumin for 12 weeks plus lifestyle advice reduced body measurements, but the change was no greater than lifestyle advice with placebo.The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and …
- In 52 adults with fatty liver disease following a lifestyle program, 1.5 grams of curcumin daily for 12 weeks did not change body mass index compared with placebo.Curcumin Offers No Additional Benefit to Lifestyle Intervention on Cardiometabolic Status in Patients with Non-Alcoholic…
- In 49 overweight adults with impaired fasting glucose, 1100 mg of berberine phytosome per day for 2 months lowered blood glucose, insulin, and visceral and total fat mass compared with placebo, with no adverse events.Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blo…
- In a randomized trial of 48 children aged 6 to 17 with overweight or obesity, a supplement combining curcumin with resveratrol, zinc, magnesium, selenium and vitamin D improved blood vessel function over 6 months, though the study did not measure weight and curcumin was not tested alone.Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study.
- In 48 women with rheumatoid arthritis, 500 mg of curcumin daily for 8 weeks lowered body weight, body mass index and waist size compared with placebo.Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheum…
- In 48 male military cadets, 1.5 grams of cinnamon daily combined with high-intensity training for 6 weeks improved fitness test scores and lowered body weight and visceral fat more than the control group, though the study cannot separate cinnamon's effect from training.Effects of Tabata-style functional training and cinnamon supplementation on army combat fitness test performance, serum …
- In 46 obese adults with poorly controlled insulin-treated type 2 diabetes, 500 or 1,000 mcg of chromium picolinate daily for 6 months lowered blood sugar control markers by the same amount as placebo, with no effect on BMI.Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western…
- In 46 adults with fatty liver disease, 400 mcg of chromium picolinate daily for 12 weeks produced greater body weight and body fat reductions than placebo, along with better antioxidant measures.Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, doubl…
- In 45 adults with fatty liver disease, 250 mg daily of phytosomal curcumin for 8 weeks reduced body weight, waist size, and body mass index more than placebo, and lowered a marker of DNA damage.Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease.
- In 44 moderately obese women doing a 12-week exercise program, 400 mcg of chromium picolinate daily did not significantly change body composition or resting metabolic rate compared with placebo.Effect of chromium supplementation and exercise on body composition, resting metabolic rate and selected biochemical par…
- In 44 women with migraine, 1000 mg daily curcumin for 8 weeks did not change weight or BMI compared with placebo, though it lowered inflammation markers and headache severity.Effects of Curcumin Supplementation on Clinical Features and Inflammation, in Migraine Patients: A Double-Blind Controll…
- In 42 overweight women with carbohydrate cravings, 8 weeks of chromium picolinate reduced food intake, hunger and fat cravings more than placebo, but the trend toward lower body weight was not statistically significant.Effects of chromium picolinate on food intake and satiety.
- In 40 overweight adults on a calorie-restricted diet, a blend containing chromium nicotinate along with several other ingredients raised resting energy burn compared with placebo during each 7-day treatment period, though the chromium dose itself was not reported and the effect cannot be attributed to chromium alone.HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the res…
- In 40 overweight adults with mixed high cholesterol, 8 weeks of a berberine-containing nutraceutical lowered cholesterol and fasting insulin more than placebo, while both groups improved body measurements without a clear difference in weight.Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a dou…
- In 40 overweight or obese insulin-resistant adults (32 finished), 3 months of pasteurized Akkermansia improved insulin sensitivity and cholesterol and slightly lowered body weight by 2.27 kg versus placebo, though the weight change was not statistically significant.Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory st…
- In 38 football players during spring training, 200 mcg of chromium picolinate daily for 9 weeks did not change body composition or strength compared with placebo.Effects of chromium picolinate supplementation on body composition, strength, and urinary chromium loss in football play…
- In 37 adults with type 2 diabetes taking a med drug, 1000 mcg of chromium picolinate daily for 6 months attenuated body weight gain and visceral fat gain compared with placebo, and improved blood sugar control.Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type …
- In 37 obese adults, 200 mg of lecithin-formulated curcumin twice daily for 6 weeks did not significantly change liver fat compared with placebo.The effect of curcumin on hepatic fat content in individuals with obesity.
- In 36 obese adults on a very-low-calorie diet followed by maintenance, 200 mcg of chromium picolinate daily for 26 weeks produced weight loss similar to the other groups and increased lean body mass compared with the other groups, while chromium yeast did not.[Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a…
- In 35 overweight women on a calorie-restricted diet and exercise, 400 mcg of chromium picolinate with conjugated linoleic acid for 12 weeks did not change weight, fat mass, or metabolic health markers compared with placebo.Chromium picolinate and conjugated linoleic acid do not synergistically influence diet- and exercise-induced changes in …
- In 35 Brazilian women with high waist circumference, 500 mg of curcumin daily for 90 days reduced body mass compared with placebo, though other body composition measures did not change.Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a rand…
- In 33 women with obesity who had lost weight, 200 mcg of chromium picolinate daily over 16 months did not prevent weight regain or change body composition compared with controls.The effectiveness of long-term supplementation of carbohydrate, chromium, fibre and caffeine on weight maintenance.
- In 33 adults with impaired glucose tolerance or type 2 diabetes, 180 mg daily of highly absorbable curcumin for six months did not significantly change body mass index compared with placebo, but it prevented a rise in oxidized LDL.Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mel…
- In 33 cancer patients with wasting syndrome, 800 mg of curcumin twice daily for 8 weeks did not produce significantly different weight or body composition changes compared with placebo.A Double-Blind, Placebo-Controlled Randomized Phase IIa Study: Evaluating the Effect of Curcumin for Treatment of Cancer…
- In a placebo-controlled trial of 32 adults with metabolic syndrome, 24 weeks of chromium with magnesium and zinc did not change metabolic risk factors compared with placebo, but it lowered C-reactive protein, a marker of inflammation.Effects of zinc, magnesium, and chromium supplementation on cardiometabolic risk in adults with metabolic syndrome: A do…
- In a placebo-controlled pilot trial of 31 women with severe obesity having bariatric surgery, 1500 mg of curcumin daily for 13 weeks reduced overall gastrointestinal symptom scores more than placebo, with gains in belching and constipation, and also lowered BMI and neck size.Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Pl…
- In 30 obese adults, 1 g daily of curcuminoids for 30 days lowered triglycerides but did not change weight, BMI or body fat compared with placebo.Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial.
- In a single-meal crossover test of 30 adults, adding 6 grams of ground cinnamon to a cereal lowered blood sugar over the first hour and across the two-hour period in normal-weight and obese people combined, but blood sugar was higher at 120 minutes.Effect of ground cinnamon on postprandial blood glucose concentration in normal-weight and obese adults.
- In 28 older adults with prediabetes, 80 mg daily of curcumin for 12 weeks lowered HbA1c blood sugar but did not change body weight or body mass index compared with placebo.Twelve-Week Curcumin Supplementation Improves Glucose Homeostasis and Gut Health in Prediabetic Older Adults: A Pilot, D…
- In 26 inactive overweight or obese women, adding cinnamon to a 4-week exercise program produced no clear extra benefit for abdominal size or sex hormones beyond exercise alone, though chest size showed a larger reduction in the cinnamon group.Effects of cinnamon supplementation combined with exercise training on anthropometric indices and reproductive hormones …
- In a 6-week placebo-controlled trial of 25 overweight children aged 9 to 12, 400 mcg of chromium chloride daily with lifestyle changes improved body fat percentage and lean mass compared with placebo, but did not change body mass index.Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: rando…
- In 24 overweight adults with binge eating disorder, chromium picolinate for about 6 months (600 or 1,000 mcg daily) significantly lowered fasting glucose compared with placebo, while weight loss was numerically greater but not statistically significant.A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and…
- In 24 adults with metabolic syndrome, 500 mg of berberine taken three times daily for 3 months reduced waist size in women and improved insulin sensitivity compared with placebo.Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion.
- In 22 overweight or obese adults with impaired fasting glucose, 500 mg of cinnamon extract daily for 12 weeks raised antioxidant levels and lowered a marker of fat damage in the blood compared with placebo.Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.
- In 20 wrestlers over 14 weeks of training, 200 mcg daily of chromium picolinate did not change body composition or strength and endurance beyond the gains from training alone.Chromium picolinate effects on body composition and muscular performance in wrestlers.
- In 20 overweight adults, a high-fat meal with a spice blend that included cinnamon lowered triglycerides by 31% after rest but not after psychological stress, and the spice blend did not change blood sugar or insulin.Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized…
- In 19 healthy older adults aged 63 to 77, 1,000 mcg of chromium picolinate daily for 8 weeks did not change body composition compared with placebo.Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body composition in healthy, no…
- In 18 older men doing resistance training, 924 mcg of chromium picolinate daily for 12 weeks did not change body weight, muscle mass, or body fat compared with placebo.Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men.
- In 18 healthy adults given 1 gram of Ceylon cinnamon extract with a meal, blood sugar over the first hour was lower than with placebo, but the two-hour total was not significantly lower; this was a single-dose study and did not measure weight.Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rat…
- In 17 older women doing resistance training, 924 mcg of chromium picolinate daily for 12 weeks did not change body fat, lean mass, or muscle size compared with placebo.Effects of resistive training and chromium picolinate on body composition and skeletal muscle size in older women.
- In 16 untrained men, 200 mcg of chromium daily alongside 12 weeks of resistance training did not change body weight or body fat compared with placebo.Effects of chromium and resistive training on muscle strength and body composition.
- In 15 women softball players doing resistance training, 500 mcg of chromium picolinate daily for 6 weeks did not change body weight or body composition compared with placebo.The effect of chromium picolinate on muscular strength and body composition in women athletes.
- In 10 young, sedentary, obese women, a single 5-gram dose of Cassia cinnamon lowered blood sugar at 30 minutes after a glucose drink compared with placebo, but did not improve insulin resistance or sensitivity.Cassia Cinnamon Supplementation Reduces Peak Blood Glucose Responses but Does Not Improve Insulin Resistance and Sensiti…
- In nine healthy young adults, 3 grams of cinnamon added to a single high-fat breakfast did not change appetite, stomach emptying, or blood fat and sugar responses compared with placebo; weight was not measured.Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to hi…
- In 8 healthy men, 3 grams of cinnamon daily for 14 days reduced blood sugar and insulin responses to a glucose drink and improved insulin sensitivity, and these effects disappeared after stopping cinnamon.Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans.
- In a 6-month placebo-controlled trial of adults with type 2 diabetes taking oral medicines, 400 mcg of chromium daily from chromium yeast did not improve blood sugar control, lipids, body weight or body fat compared with placebo.Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, p…
- In patients with colorectal cancer, curcumin lowered serum TNF-alpha and increased body weight, so the weight result was not a reduction.Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin.
- In 95 Navy personnel who completed a 16-week exercise program (79 men and 16 women), 400 mcg of chromium picolinate daily did not reduce body fat or body weight more than placebo.Effects of chromium picolinate on body composition.
- In 38 adults with type 2 diabetes (20 took quercetin, 18 did not), 500 mg of quercetin daily for 12 weeks lowered waist size by 1.5% versus 0.7% in the comparison group, a difference that was not statistically significant, though anxiety and quality of life scores improved.The Impact of Three-Month Quercetin Intake on Quality of Life and Anxiety in Patients With Type II Diabetes Mellitus: An…
- In a 12-week trial of 30 adults with type 2 diabetes, eating chromium-enriched whole wheat bread daily was associated with a significant reduction in body weight, blood sugar and systolic blood pressure, compared with before the trial.Controlling type-2 diabetes by inclusion of Cr-enriched yeast bread in the daily dietary pattern: a randomized clinical …
- In a placebo-controlled crossover study of 20 overweight African-American women dieting and exercising, 600 mcg of niacin-bound chromium daily for 2 months led to greater fat loss and less muscle loss in the first group, but the second group showed the opposite result.Effects of niacin-bound chromium supplementation on body composition in overweight African-American women.
- In 78 adults with metabolic syndrome, a multi-herb product containing turmeric taken for 4 months reduced body weight by about 1.7 kg and waist size by about 3 cm, though there was no placebo group.Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrom…
- In 44 overweight adults, a diet program plus a nutraceutical blend that included berberine for 13 weeks produced greater loss of body mass and fat than diet alone, though the study could not separate the supplement's effect from the diet's.A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targe…
- In a small open-label crossover study of 12 adults with type 2 diabetes, 40 days of honey formulated with cinnamon, chromium and magnesium was associated with a 2.2 kg weight reduction, but it did not improve blood sugar control compared with plain honey.The effect of a cinnamon-, chromium- and magnesium-formulated honey on glycaemic control, weight loss and lipid paramete…
- In 12 overweight women with polycystic ovary syndrome, 1100 mg per day of a bioavailable berberine formulation for 60 days lowered body mass index, visceral fat, and inflammation markers, with no change in liver or kidney function.Read the study on PubMed (34684666) →
- In people with cystic fibrosis, eight weeks of curcumin with genistein showed no clear effect on body mass index.Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1…
- In obese and diabetic mice, pasteurized Akkermansia and its membrane protein Amuc_1100 reduced fat mass, insulin resistance and cholesterol; a human safety test of live and pasteurized Akkermansia also found it safe.A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and d…
- In mice with colon cancer, a daily antioxidant mix containing quercetin speeded weight loss and shortened survival, and did not prevent muscle wasting; this was an animal study with no human participants.Antioxidant supplementation accelerates cachexia development by promoting tumor growth in C26 tumor-bearing mice.
- In a mouse study, a combination of a med and quercetin cleared fat-cell populations linked to insulin resistance and eased insulin resistance; the study did not test quercetin alone, did not measure body weight, and involved no human participants.Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Review Totals and Summary
Members Only133 reviews · 83% positive
California Gold Nutrition GLP-1 Supreme has generated a range of feedback from real users, though the sentiment leans largely positive. Many customers praise the product for delivering noticeable benefits tied to appetite management and overall well-being. A recurring point in numerous reviews is that users have felt a genuine difference in their cravings and have found it easier to manage portion sizes, which they attribute to consistent use of this supplement. Several reviewers also mention feeling more energized or generally better, noting that the product fits easily into their daily routines thanks to its straightforward dosing and neutral taste, which doesn't overpower or linger. Customers often express satisfaction with the perceived quality, highlighting that capsules are easy to swallow and the packaging arrived intact and prompt, as expected from iHerb orders. It's also common to find reviewers who have been integrating it with other health strategies and are pleased with the support it provides, remarking that it has become a staple in their supplement regimen. However, not all users share the same level of enthusiasm. A smaller group reports more neutral reactions, with several stating that while the product is easy to take, they haven't experienced any significant or dramatic results. Some note that effects are subtle or have taken longer to manifest than anticipated, which has led to ambiguous feelings about continued use. These reviewers sometimes question whether the supplement’s benefits are truly noticeable or perhaps being influenced by other lifestyle changes they’re making simultaneously. There are also occasional mentions of users not detecting much change at all and expressing uncertainty on whether they would repurchase, although they tend to appreciate the product’s lack of negative side effects. On the negative end of the spectrum, a minority of customers are dissatisfied, primarily pointing to a lack of perceivable effect. A handful mention that they saw no changes in appetite or energy, regardless of consistent use, and conclude the product did not meet their expectations. In rarer cases, some complaints relate to shipping delays or packaging, but these are less about the actual supplement and more about the ordering process. Notably, there are very few reports of adverse reactions or problems with tolerability, which suggests that, even for less satisfied customers, side effects are not a prominent issue. Overall, the prevailing theme among reviews for California Gold Nutrition GLP-1 Supreme is moderate to high satisfaction, especially in terms of ease of use and incremental support for appetite management. While many users seem happy with their purchase and eager to recommend it for those seeking gentle, supplementary wellness support, there’s also a notable group who find the results subtle or inconclusive, alongside a small but clear segment left disappointed by the lack of tangible effects. This blend of feedback underscores the variable nature of supplement response and highlights that, though positive experiences are most common, individual results can vary considerably.
Biohacker Summary
Members Only8 of 10 recommend it
The panel leans toward curcumin, the main ingredient: four of the ten recommend it and one uses a nanoparticle version, while four are neutral and one warns against it during pregnancy. People take it mainly for inflammation, with some also citing joint pain, immune support, brain health and aging. On forms, one prefers the phytosomal kind because standard curcumin is broken down quickly, one favors tetrahydro curcuminoids, one notes it barely absorbs without black pepper, and one suggests eating it in curries, but no one gives a dose. One panelist adds that no supplement replaces sleep, food, exercise and stress care, and another says another compound outperforms curcumin for one body pathway. Berberine is a smaller ingredient in this product and is the most discussed, with several using or recommending it for blood sugar, though one stopped it because of headaches and a blood sugar drop, and another warns against taking it on an empty stomach.
See all 10 biohackers →Hide the biohackers
Dave Asprey · Curcumin · uses
- Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
- Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
- Recommends taking Akkermansia directly as a supplement to restore its levels, which can raise insulin sensitivity by 28% over three months by maintaining the lining of the intestines.
- Recommends berberine as a good alternative to a med for longevity, citing its similar pathway effects without the downsides and its positive impact on the microbiome.
- Dave Asprey discusses berberine as a plant compound that genuinely lowers blood glucose, comparable to a med in some trials, but notes its poor absorption and lack of lifespan data, classifying it as a glucose drug, not a longevity drug.
- Recommends quercetin, found in foods like capers and red onions, as a plant compound that directly slows down the demolition crew inside cells, which destroys NAD+.
- Dave Asprey mentions how Akkermansia improves mitochondrial function and blood sugar control.
- Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
- Notes that berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch.
- Dave Asprey recommends quercetin, a plant compound found in capers and red onions, as it has been shown to directly slow down the demolition crew inside cells that breaks down NAD+.
- Believes quercetin is important for addressing mast cell activation.
- Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
- Warns that cinnamon is high in oxalate.
- Sees great success with quercetin as a mast cell stabilizer.
Dr. Eric Berg · Curcumin · neutral
- Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
- Recommends adding berberine as another natural remedy to the combination for cancer.
- Dr. Eric Berg states that Berberine combined with a lower-carb diet may help support healthy blood sugar levels and reduce cravings over time.
- Notes that some people add berberine, which supports healthy blood glucose and makes one insulin resistant.
- Notes that Curcumin barely absorbs without black pepper.
- Recommends taking berberine to block the effects of grains.
- Recommends adding a pinch of cinnamon to water daily, stating that it mimics insulin and activates insulin receptors, making cells more sensitive to insulin to help regulate blood sugar.
- Recommends consuming cinnamon to block the effects of grains.
- Suggests incorporating anti-cancer foods like berberine to help prevent pancreatic cancer.
- Dr. Eric Berg recommends adding more quercetin-rich foods such as red onions, capers, kale, dill, and radishes to your diet for seasonal allergies.
- Recommends taking a pinch of cinnamon with apple cider vinegar in a glass of water three times a day to stabilize blood sugar and reduce carbohydrate cravings.
- Cinnamon may be a more powerful combination with apple cider vinegar than you think, as both have been studied for their potential role in supporting healthy blood sugar levels.
- Explains that the quercetin in onions decreases DHT, a powerful form of testosterone that is often the reason for hair loss.
- Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
Thomas DeLauer · Curcumin · recommends
- Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
- Mentions dihydroberberine as a component that can be used to optimize and support the AMPK pathway, helping to tune it up and have a higher baseline.
- Has found berberine to be very helpful for some of his patients who are night snackers, especially those with a sweet tooth.
- Warns that elevated Akkermansia levels in conjunction with low-fiber diets can increase the likelihood of type 2 diabetes, as Akkermansia will eat the gut lining without other food sources.
- Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
- Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
- Recommends berberine if one is going to have fruit later in the day, as it specifically restores the AMPK-driven fat suppression.
- Recommends Dihydroberberine to improve mitochondrial performance and turn up the AMPK dial.
- Describes quercetin as 'unreal' and notes its high presence in apples and onions, stating it stabilizes mast cells to release less histamine.
- Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
- Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
- Recommends Berberine, stating that 500mg taken three times with meals has shown comparable results to a med in dropping HbA1c and fasting glucose.
- Recommends Ceylon cinnamon for pancreas health, describing it as an insulin mimetic that eases beta cell load.
- States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
Siim Land · Curcumin · recommends
- Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends berberine as a herbal supplement that increases fat metabolism, lowers mTor and blood sugar, making it a good combination for increased autophagy, and notes that meta-analyses show it reduces blood sugar, promotes weight loss, and decreases cholesterol.
- Recommends Berberine for blood sugar and cholesterol, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Curcumin as one of 15 supplements backed by human studies.
- Lists Berberine as one of 15 supplements backed by human studies.
- Mentions quercetin as a phytochemical that has been shown to stimulate GLP-1 expression directly, and also increase glucose uptake and insulin sensitivity.
- Advises caution when using berberine with glycine, as it is a glucose-lowering medication.
- Thinks curcumin has some of the strongest evidence and is worth considering.
- Is skeptical about most supplements, including berberine, because he doesn't see any evidence to back up their claims, which are often based on personal testimonials.
- Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- Mentions berberine as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- Recommends chromium as a mineral that can lead to better body composition.
- States that curcumin, unless contaminated, is not going to raise liver enzymes.
- Includes cinnamon powder in their supplement stack.
Dr. Mark Hyman · Curcumin · recommends
- States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
- Recommends adding cinnamon to coffee as a way to enjoy fall flavors without the high sugar content.
- Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
- Recommends curcumin as an anti-inflammatory supplement that can be helpful.
- Dr. Mark Hyman designed 'The World's Smartest Smoothie' using organic ingredients, including Organic Cinnamon.
- Takes 500 mg of Berberine with meals for blood sugar control.
- States that curcumin helps to lower broader inflammatory levels in the body.
- States that he uses Quercetin, a flavonoid and one of the best-studied natural mast cell stabilizers, for allergies and as a longevity compound, noting it pairs well with bromelain for absorption.
- Mentions that HTB Immune Energy Chews contain over 100 immune active polyphenols like quercetin, which are studied for supporting healthy immune balance and longevity.
- Notes that quercetin is one of the immune active polyphenols found in sprouted Himalayan tardy buckwheat, studied for supporting healthy immune balance and longevity.
- Adds a little bit of cinnamon to his overnight oats, noting that it helps blood sugar.
- Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
- Dr. Mark Hyman, agreeing with the guest, mentions Quercetin as a supplement that can help with modifying the histamine response.
- Includes cinnamon in their smoothie to help with blood sugar balance.
Dr. Rhonda Patrick · Curcumin · neutral
- Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
- Notes that berberine is a promising compound for cardiovascular health, with potential benefits spanning lipid metabolism, artery health, and the gut microbiome.
- Notes that berberine lowers LDL cholesterol in randomized trials and is interested in its connection to ApoB, artery plaque, and the gut microbiome.
- Notes that berberine has been on their radar for glucose control for years, and a new study on a biooptimized form of berberine showed reductions in fasting glucose, improved glucose tolerance, and an increase in fasting.
- Asks if curcumin can slow aging.
- Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
- Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
- Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
- Recommends berberine for atherosclerosis, noting it has a more compelling evidence base, showing reduction in plaque formation and improvement in LDL, HbA1c, and glucose regulation.
- Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
- Recommends Berberine for optimizing blood glucose, noting that meta-analyses show it reduces fasting glucose and HbA1c in people with type 2 diabetes.
- Notes that Berberine may not have the same inhibitory effect on muscular hypertrophy and strength gains as a med, but there are currently no studies to support or refute this.
- Discusses ideal dosing for berberine.
- Notes that berberine is also effective for blood glucose regulation, similar to apple cider vinegar.
Ben Greenfield · Curcumin · neutral
- Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
- Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
- States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
- States that quercetin inhibits proteasome, which has an effect on Nrf2 activation.
- States that berberine is great for sleep, upregulating serotonin and dopamine, and that their bioavailable berberine product is taken by 75% of users for sleep, even though it was created for blood glucose management.
- Recommends cinnamon, noting it is a bark and not a seed, for use on the AIP diet.
- Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
- Mentions quercetin or other senolytics to clear senescent cells as a recommended intervention on the True Age test.
- Ben Greenfield's Akkermansia decreased after FMT, which Ben Greenfield attributes to having stopped taking a Pendulum probiotic that contained a great deal of Akkermansia.
- Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
- Now uses berberine as a natural strategy instead of a med and as a natural insulin-sensitizer.
- Offers berberine as a natural alternative for better blood sugar control.
- Recommends berberine or dihydroberberine as a powerful insulin sensitizing agent and a good alternative to a med, noting its comparable hemoglobin A1c reductions in some type 2 diabetes trials.
- Now uses Ceylon cinnamon as a natural strategy instead of a med and as a natural insulin-sensitizer.
Andrew Huberman · Curcumin · neutral
- Discusses curcumin as a supplement for prenatal care and sperm health.
- Takes 500 mg of berberine with meals to help with blood glucose.
- Dr. Huberman states he will skip berberine because it gives him brutal headaches, makes him crave carbohydrates, and drops his blood sugar.
- Discusses berberine and other potent molecules for regulating blood glucose.
- Warns that berberine is a serious step and one should talk to their doctor about it, as taking it on an empty stomach can cause hypoglycemia, brutal headaches, dizziness, and impaired vision; however, when taken with a large, carbohydrate-rich meal, he felt fine on up to 750 mg or a gram.
- Recommends cinnamon as a tool to reduce blood sugar cravings.
- Warns that cinnamon contains a med, which can be toxic at high levels, so one should not ingest more than about a teaspoon to a teaspoon and a half per day to avoid exceeding the problematic threshold.
- Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
- Mentions the use of fasting-related supplements, including berberine.
- Huberman warns that if you take berberine without ingesting carbohydrates, many people, including himself, experience a splitting headache due to becoming hypoglycemic, as it is a glucose clearing agent.
- Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
- States that berberine can further support fat loss and discusses its impact on insulin.
- Mentions berberine as a compound, derived from a plant, that is in growing use for reducing blood glucose and is very potent at doing so.
- Includes curcumin in his diet because it has been shown to stimulate GLP-1.
Peter Attia · Curcumin · uses
- Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
- Uses cinnamon in his keto mousse in the evening.
- Quercetin, a bioactive flavonoid present in red wine, can impair alcohol metabolism.
- Puts a little bit of cinnamon on air-popped popcorn.
- Peter discusses the potential therapeutic uses of Akkermansia for gut health from the Colleen Cutcliffe episode.
- Sells a product that is just pure Akkermansia, which is one of their best sellers, and many practitioners use it to boost this strain back up in people who are low in Akkermansia based on gut microbiome tests.
- Notes that Quercetin is often given in combination with a med as an anti-senescent drug.
- Used to take berberine, which he called "poor man's a med," to buffer blood glucose and feel less sick after ingesting large amounts of calories on a cheat day, but stopped when he no longer followed the Slow Carb Diet.
- States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
- Uses berberine in clinical practice as a weak inhibitor of the enzyme PCSK9, which can help a subset of patients who overexpress PCSK9 and have high LDL cholesterol.
- Suggests Thorne as the brand for berberine when recommending it to patients.
- Uses berberine in clinical practice as a weak inhibitor of the enzyme PCSK9, which can help lower LDL cholesterol in a subset of people who overexpress PCSK9.
- Mentions that quercetin, found in fruits and onions, was one of the first two plant molecules discovered to activate human sirtuin one, alongside piceatannol, before resveratrol was identified.
- Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
Bryan Johnson · Curcumin · warns
- Advises avoiding Curcumin during pregnancy.
- Launched a new product for a healthy microbiome, built around Akkermansia muciniphila, a keystone bacterium that decreases with age and is linked to metabolic health.
- Uses half a teaspoon of Ceylon cinnamon in his Nutty Pudding for blood sugar, liver, and pancreas health.
- Includes cinnamon in his Green Giant drink, which he consumes first thing in the morning.
- Bryan Johnson uses ½ tsp of ceylon cinnamon in his Nutty Pudding.
RAL Summary
Members OnlyTier 2 for Weight and Metabolism for Women
Curcumin is at a full dose, and seven pooled analyses show a small but consistent drop in body weight, the largest with 7,216 people [1]. Most of the other ingredients are at low or unclear doses, or did not help weight in women.
Where the evidence disagrees: 55 of the 152 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Metabolic system, Endocrine system, Digestive system
Combine with: Not compulsory.
Possible side effects: No major side effects reported. One review of curcumin in women with polycystic ovary syndrome found no more side effects than placebo.
Supplement Facts
Chromium 70 mcg · Quercetin 250 mg · Amorphous Turmeric Curcumin Complex 200 mg
| Chromium (as Chromium Picolinate) | 70 mcg | 200% |
| Quercetin (as Quercetin Dihydrate) (from Fava d'Anta Extract) (pods) | 250 mg | † |
| Amorphous Turmeric Curcumin Complex (Turmeric Rhizome Oleoresin [27% Curcumin], Hypromellose, Maltodextrin) | 200 mg | † |
| Dihydroberberine (DHB) | 200 mg | † |
| Akkermansia (AKK) (Pasteurized) (Akkermansia muciniphila) | 150 mg | † |
| Cinnamon Extract (Cinnamomum burmannii) (bark) (Std. to 3% Type-A Polymers) | 125 mg | † |
Other ingredients: Modified Cellulose (Hypromellose Veggie Capsule), Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide (Silica).
Directions: Take 2 capsules daily, with food. Best when taken as directed by a qualified healthcare professional.
Barcode (UPC) 898220025398 · Label source: iHerb · Report a label change
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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