Cellucor Super HD Powder Strawberry Lemonade Review
Cellucor Super HD Powder is presented on this page as a high-definition fat targeting and sculpting agent. The page describes it as featuring iFAS503 for energy and focus, along with appetite control and fat metabolism support. The product is sold as a powder with 30 servings per container, and this listing offers Strawberry Lemonade and Peach Mango flavours. The Strawberry Lemonade variant is listed under SKU 810390024858 at $29.93, while a second Strawberry Lemonade entry is shown at $28.35 without a barcode. The product is categorised under Supplements and the vendor is Cellucor. The page lists a weight of 0.55 lb and dimensions of 3.250 inches wide by 3.500 inches high by 3.250 inches deep. Directions state that, as a dietary supplement, a user should begin with one level scoop mixed with 8 to 10 ounces of water in the morning on an empty stomach, then take a second scoop five to six hours later in mid-afternoon to assess tolerance. If well tolerated, an additional scoop may be added to the morning serving, for a total of three servings per day. The directions warn not to exceed one scoop in the morning during the first several days of use and until tolerance is assessed, and not to exceed three servings in a 24 hour period. Users are told to drink plenty of water to avoid dehydration. The product may be taken for up to eight weeks, then should be discontinued for a minimum of four weeks. The warnings say the product should not be used if pregnant or nursing, and is intended only for healthy adults aged 18 or older. Users with a prescription or over the counter medication, or with conditions such as high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, or prostate enlargement causing urinary difficulty, are told to consult a physician first. Those taking a MAOI or any other medication are also advised to consult a physician. Users should stop and consult a health professional on any adverse reaction, should not use the product if the safety seal is broken or missing, and should store it in a cool dry place out of reach of children. The nutrition panel lists a serving size of one scoop with 30 servings per container and 10 calories per serving. Each serving contains 4.0 grams of total carbohydrate, 3.0 grams of dietary fiber, 18 milligrams of calcium, 10 milligrams of niacin, 3 milligrams of vitamin B6, and 250 micrograms of vitamin B12. The page also lists a 521 milligram SuperHD Thermo-Sensory Blend containing 160 milligrams of caffeine anhydrous, along with N-Acetyl-L-Tyrosine, Rhodiola rosea root extract, green tea leaf extract, Slimpro protein hydrolysates of blue whiting, amla fruit extract, yohimbe bark extract, capsimax cayenne fruit extract, evodia rutaecarpa fruit extract standardized for evodiamine, dandelion root extract, toothed clubmoss extract standardized for huperzine A, and Rauwolfia vomitoria root bark extract.
Study, Trial or Testing Result Summary
Members Only60 human studies · 17 improved
4 of these 60 human studies gave the ingredient by injection, not by mouth.
This pre-workout's main ingredients sit in a 521 mg proprietary blend. The store listing names caffeine and several herbal extracts in it, but no studies were given for the blend, and the amount of each ingredient other than caffeine is not disclosed. The vitamins on the label do not show an energy benefit in studies. For niacin, a review pooling 27 studies of 1,599 adults found related compounds did not improve tiredness [1], and 2000 mg of a related form daily did not ease fatigue in people with long-lasting COVID symptoms [2]. A single 1000 mg dose of niacin actually shortened time to exhaustion during cycling [3]. This product has only 10 mg. Vitamin B6 is here at 3 mg, well below the 50 mg that eased tiredness in women with premenstrual symptoms [4]. A 3-year trial of low-dose B vitamins including 3 mg of B6 did not improve quality of life [5]. Vitamin B12 did not boost energy in people who were not deficient [6], and a mix containing it did not change fatigue in dialysis patients [7]. Calcium is a trace 18 mg, far below the 1000 mg a day that reduced tiredness in one premenstrual trial [8]. Animal and cell studies are never counted.
See all 60 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- Across 27 studies of 1,599 adults, NAD+ precursors did not improve perceived fatigue or sleep, but nicotinamide mononucleotide improved endurance and NADH improved cognitive performance.Domain-specific effects of NAD+ precursors on fatigue and functional performance: a systematic review and network meta-a…
- In 10 trials of 489 people, NADH was well tolerated and linked to better quality of life, less anxiety and lower heart rate after stress, but fatigue results were not clearly shown.Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of 14 reviews found oral niacin and nicotinamide can cause side effects including fatigue, stomach upset, flushing and liver problems, more often at higher doses and with niacin than nicotinamide.The adverse effects of oral niacin/nicotinamide - an overview of reviews.
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 202 dialysis patients given a multinutrient mix including niacin for 12 weeks, fatigue and quality of life did not differ from placebo, though heart rate variability and a herpes virus marker improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 160 heart disease patients over about 38 months, niacin plus a med caused fatigue, nausea or muscle aches in 9% versus 5% on placebo, not a significant difference.Read the study on PubMed (14759379) →
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 58 people with long-COVID, 2000 mg of nicotinamide riboside daily raised blood NAD+ about 3-fold but did not significantly improve fatigue, cognition, or sleep versus placebo.Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled …
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 50 people recovering from COVID-19, one month of 1-methylnicotinamide improved 6-minute walk distance in 92% versus 60% without it, and severe fatigue was 20% versus 56%.Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19.
- In 43 adults with sleep complaints, a blend containing a small amount of vitamin B3 taken with the evening meal for 14 days shortened sleep onset time and improved next-morning mood and vigor, but had no effect on cognitive performance.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 healthy adults aged 40-76, a glycine, glutamine and niacin mixture taken for 3 weeks raised growth hormone by about 70% compared with placebo, but did not change IGF-I, mood or memory.Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 32 Gulf War veterans with illness, a 4-6 week program of exercise, sauna and nicotinic acid plus other supplements improved physical quality of life by 6.9 points versus waitlist, and 11 of 16 quality of life, pain and fatigue measures improved.A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 25 healthy active adults, a single dose of a pre-workout blend containing 60 mg niacin raised reported vigor and energy and improved cognitive scores compared with placebo, with no gain in lifting or sprint performance.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In a double-blind crossover trial of 25 resistance-trained adults, 7 days of a pre-workout drink containing 65 mg niacin (plus caffeine and other ingredients) improved some lower-body strength and endurance measures compared with placebo, but not cycling time-trial performance, with no differences in side effects.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 25 untrained men, a single 1000 mg dose of niacin before cycling raised the respiratory exchange ratio and shortened time to exhaustion compared with caffeine, suggesting impaired exercise performance.Niacin supplementation impairs exercise performance.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 21 untrained men, a caffeine supplement containing 40 mg of niacin taken once did not improve bench press strength, leg extension strength, or time to exhaustion on a bike compared with placebo.Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion durin…
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In a placebo-controlled crossover pilot in healthy middle-aged adults, 7 days of RiaGev (1520 mg twice daily) raised blood NAD+ metabolites and reduced fatigue and improved concentration and motivation compared with baseline, with no clinically relevant side effects.A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 70 diabetic fatty liver patients, 1000 mg of nicotinamide daily for 12 weeks improved quality of life including the activity and fatigue scores versus no supplement, in an open-label trial.Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In a 3.5-year study of 1,643 adults aged 65 and older, those with the lowest dietary vitamin B6 intake had about 2.8 times the odds of developing frailty, which includes exhaustion, compared with those with the highest intake. This is an association from diet, not proof that supplements prevent frailty.Low vitamin intake is associated with risk of frailty in older adults.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
- In hypertensive patients, a nicotinamide mononucleotide supplement lowered blood pressure and improved vascular function, but energy was not measured.NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension.
- In this mostly lab and animal study, nicotinamide with pyridoxine helped muscle stem cells regenerate muscle and improved strength in animals, but energy was not measured.Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
Review Totals and Summary
Members Only3,000 reviews · 90% positive
Buyers are split. The few who like it praise the flavor and a clean energy lift, but most reviews are about powder that arrived clumped, hard or moist, which suggests a storage or freshness problem with some sellers. **What buyers say it did for them:** The happy reviewers describe a noticeable boost in energy without side effects. One says it gives "a safe caffeine boost with no jitters or racing heart." Another says "I work out with explosive energy! My bike rides improve." A third calls it "High quality and worth the price for the benefit!" **What they complain about:** The main complaint is the condition of the powder. Several buyers got tubs with hard clumps or moisture. One says "the powder was all clumpy and on the bottom half of the powder was rock hard." Another ordered three containers and found the same problem in each: "1st one was moist and stuck together instead of being a full powder." Some suspect old stock or poor storage by the seller. One buyer wrote "Old, clumped rock hard," and another noted a returned set of jars that looked unopened. One reviewer also reported an expiration date that made them think the product had sat in a warehouse. Several asked for refunds or said they were returning the product. **Taste, smell and form:** Taste divides reviewers. One says "It's got great flavor," and another says "Taste great too!" A third says "The flavor is terrible," though that review also mentions clumping, so the bad batch may have affected it. Clumping is the main issue with the form. One buyer had to break the powder up by hand before using it. One review concerned a watermelon powder rather than strawberry lemonade, so its comments are only loosely relevant. Reviews of other forms of the product, such as gummies and capsules, were left out. **Value for money:** Only one review speaks directly to value, and it is positive: "worth the price for the benefit." Another buyer enjoyed the single-serve packets enough to buy a canister on a deal. Buyers who received clumped tubs felt they had not got what they paid for. One said "it's unacceptable I would like my money back." One buyer who had bought the product elsewhere said it had never been this poor in quality. **Who it seems to suit and who it did not:** The product seems to suit people who want a pre-workout for energy during exercise and who tolerate caffeine well. Those reviewers were happy with the effect and flavor. It did not suit buyers who got a damaged or old tub. Several reviewers advise caution about where to buy. One says "buy it from Walmart, not third party sellers," and another says they stopped buying pre-workout from third-party sellers after repeated bad experiences. If you do buy it, check the seller, check the expiration date, and look closely at the powder on arrival. A fresh tub looks to be a very different experience from the clumped ones described.
Biohacker Summary
Members Only9 of 10 recommend it
Vitamin B12 is the main ingredient, and the panel leans toward it: four of the ten recommend it, mainly for brain function, mood, nerve protection, and fixing a deficiency, and two more use it. One suggests a liposomal and micellar methylcobalamin form for better absorption, another advises keeping blood levels around 500, and one advises testing first and supplementing only if low. Two panelists were neutral, noting that a deficiency can cause fatigue or hair loss, and one warns that B12 should not be taken too close to bedtime because it enhances light's melatonin-suppressing effects. Vitamin B6 also counts as a main ingredient: one panelist uses it and recommends it with folate and B12 for PMS, one avoids it because too much can damage nerves, and one lists the synthetic pyridoxine form as something to avoid. Calcium and niacin are smaller ingredients in this product, with calcium mostly recommended for bones.
See all 10 biohackers →Hide the biohackers
Thomas DeLauer · Vitamin B12 · recommends
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
- Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
Dr. Eric Berg · Vitamin B6 · warns
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
- Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
- Recommends taking vitamin B12 if on a med.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
- States that green leafy vegetables are great sources of calcium.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
- Lists Vitamin B12 as important for nerve health and energy.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Lists niacin as a B vitamin cofactor that helps mitochondrial function.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
Ben Greenfield · Vitamin B12 · recommends
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Mentions niacin as a natural approach that might be good for plaque regression.
- Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
- Notes that 10X Health System's methylene blue tablets plus light stack supports energy and recovery at the cellular level by promoting healthy metabolism through niacinamide.
- Uses Niacinamide as a clean building block for NAD+ as part of NAD Regen.
- Warns that in high doses, calcium without the right cofactors can raise cardiovascular risk by contributing to arterial calcification instead of bone strength, and may increase the risk of osteoporosis.
- Recommends priming the skin with niacinamide to reduce hyperpigmentation, noting its effectiveness in reducing hyperpigmentation by 50% in an ex-girlfriend's laser burn.
Dave Asprey · Vitamin B12 · recommends
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
- Notes that niacin has been a standard longevity ingredient since the 1990s.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Dave discusses how niacinamide compares as an NAD precursor.
- Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
- Used niacin for a while to address plaque in his arteries and high LP(a), but stopped because it caused high liver values and made him feel unwell, despite dropping his LP(a).
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Recommends taking calcium citrate during a high oxalate meal to bind the oxalate in the gut.
- Notes that people often take calcium for bone health.
Siim Land · Vitamin B12 · uses
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- Lists dairy and sardines as sources of Calcium.
- Notes that Boron reduces calcium/magnesium loss.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
- Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
- Recommends a high calcium intake for bone health.
- Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
- Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
- Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
- Recommends niacin as a much cheaper and equally effective NAD booster compared to NMN and NR.
- Warns that niacin, an NAD precursor, can shorten sleep.
- Recommends taking 100-300 milligrams of niacin before a sauna session, as part of the Hubert protocol, to enhance sweating, vasodilation, and potentially detoxification and cardiovascular benefits.
- Warns that Niacin, especially at high doses like 2000 mg per day, can disrupt sleep by increasing energy levels too high, causing flushing, and reducing deep sleep while increasing shallow non-REM sleep.
Andrew Huberman · Vitamin B12 · neutral
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
- Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
- Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
- Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Recommends the consumption of B12 and other B vitamins, especially folate, as it has been shown to partially decrease cancer risk in people who ingest alcohol, though it does not completely offset it.
- Started taking AG1 in 2012 and still takes it once or twice a day because it covers foundational vitamin, mineral, and probiotic needs, and supports immune system function and a healthy gut microbiome.
- Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
- He has been using Athletic Greens for over a decade to cover his vitamin and mineral bases and support his gut microbiome, immune system, gut-brain axis, and mental functions.
Dr. Rhonda Patrick · Vitamin B12 · warns
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
- Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
- Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
- Around 38% doesn't meet the requirement for calcium.
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Takes a calcium-magnesium pill because he believes people tend to be short of both and that the body cares about the ratio of these similar molecules.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
- Dr. Rhonda Patrick explores vitamin B12 and autism risk.
- She takes methyl B12 as part of her Thorne multivitamin, which helps keep her homocysteine levels below 9 micromoles per liter.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends continuing with calcium to support bone health during the follicular phase.
- Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
- He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
Peter Attia · Vitamin B12 · neutral
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
- Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
- Recalls that a flush from niacin typically occurred with doses of a few grams.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
- He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
- Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
- States that niacin is a dead drug and is not recommended by any guidelines, though some still selectively use it for Lp(a).
RAL Summary
Members OnlyTier 3 for Energy
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Metabolic system, Cardiovascular system
Combine with: Because this product is a stimulant-based energy and thermogenic formula, it should not be relied on for regularity. For long-term bowel regularity, consider pairing a different regimen with soluble fiber such as psyllium husk or partially hydrolyzed guar gum, magnesium citrate or magnesium oxide for gentle osmotic support, and a probiotic with strains like Bifidobacterium lactis BB-12 or Lactobacillus rhamnosus GG. Adequate water intake, and optionally prunes or sorbitol-rich foods, also help. If you continue using Super HD for energy, take it earlier in the day with plenty of water, and pair it with L-theanine to smooth out caffeine's jitteriness and with electrolytes to support hydration. Check with a healthcare provider if constipation is persistent or you take medications.
Possible side effects: Studies note that niacin can cause flushing, stomach upset, fatigue and liver problems, mostly at doses far higher than in this product. No written reviews were read for side effects.
Supplement Facts
Total Carbohydrates 4 g · Niacin 10 mg · Vitamin B6 3 mg
| Calories | 10 | |
| Total Carbohydrates | 4 g | |
| Niacin | 10 mg | |
| Vitamin B6 | 3 mg | |
| Vitamin B12 | 250 mcg | |
| Calcium | 18 mg | |
| SuperHD Thermo-Sensory Blend (Combination) | 521 mg | † |
Other ingredients: Polydextrose, Natural and Artificial flavors, Malic Acid, Citric Acid, Calcium Silicate, Sucralose, Silicon Dioxide, FD&C Red Lake #40, Acesulfame Potassium, Xanthan Gum.
Barcode (UPC) 810390024858 · Label source: NIH label database · Report a label change
Show entire label
Where to Buy
Myshopify · Supp
More energy products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataTermsDo Not Sell or Share My Personal InformationCookie settings


