Cellucor Super HD Powder Strawberry Lemonade Review

Cellucor Super HD Powder is presented on this page as a high-definition fat targeting and sculpting agent. The page describes it as featuring iFAS503 for energy and focus, along with appetite control and fat metabolism support. The product is sold as a powder with 30 servings per container, and this listing offers Strawberry Lemonade and Peach Mango flavours. The Strawberry Lemonade variant is listed under SKU 810390024858 at $29.93, while a second Strawberry Lemonade entry is shown at $28.35 without a barcode. The product is categorised under Supplements and the vendor is Cellucor. The page lists a weight of 0.55 lb and dimensions of 3.250 inches wide by 3.500 inches high by 3.250 inches deep. Directions state that, as a dietary supplement, a user should begin with one level scoop mixed with 8 to 10 ounces of water in the morning on an empty stomach, then take a second scoop five to six hours later in mid-afternoon to assess tolerance. If well tolerated, an additional scoop may be added to the morning serving, for a total of three servings per day. The directions warn not to exceed one scoop in the morning during the first several days of use and until tolerance is assessed, and not to exceed three servings in a 24 hour period. Users are told to drink plenty of water to avoid dehydration. The product may be taken for up to eight weeks, then should be discontinued for a minimum of four weeks. The warnings say the product should not be used if pregnant or nursing, and is intended only for healthy adults aged 18 or older. Users with a prescription or over the counter medication, or with conditions such as high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, or prostate enlargement causing urinary difficulty, are told to consult a physician first. Those taking a MAOI or any other medication are also advised to consult a physician. Users should stop and consult a health professional on any adverse reaction, should not use the product if the safety seal is broken or missing, and should store it in a cool dry place out of reach of children. The nutrition panel lists a serving size of one scoop with 30 servings per container and 10 calories per serving. Each serving contains 4.0 grams of total carbohydrate, 3.0 grams of dietary fiber, 18 milligrams of calcium, 10 milligrams of niacin, 3 milligrams of vitamin B6, and 250 micrograms of vitamin B12. The page also lists a 521 milligram SuperHD Thermo-Sensory Blend containing 160 milligrams of caffeine anhydrous, along with N-Acetyl-L-Tyrosine, Rhodiola rosea root extract, green tea leaf extract, Slimpro protein hydrolysates of blue whiting, amla fruit extract, yohimbe bark extract, capsimax cayenne fruit extract, evodia rutaecarpa fruit extract standardized for evodiamine, dandelion root extract, toothed clubmoss extract standardized for huperzine A, and Rauwolfia vomitoria root bark extract.

Product Focus: EnergyAlso covers:BrainMetabolismHeart
Tier ⓘ
Tier 3
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
72 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 3,000
Biohacker Mentions
9 of 10
Cost per month
$30

Study, Trial or Testing Result Summary

Members Only60 human studies · 17 improved

4 of these 60 human studies gave the ingredient by injection, not by mouth.

60 human studies17 improved33 no effect35,431 people studied

This pre-workout's main ingredients sit in a 521 mg proprietary blend. The store listing names caffeine and several herbal extracts in it, but no studies were given for the blend, and the amount of each ingredient other than caffeine is not disclosed. The vitamins on the label do not show an energy benefit in studies. For niacin, a review pooling 27 studies of 1,599 adults found related compounds did not improve tiredness [1], and 2000 mg of a related form daily did not ease fatigue in people with long-lasting COVID symptoms [2]. A single 1000 mg dose of niacin actually shortened time to exhaustion during cycling [3]. This product has only 10 mg. Vitamin B6 is here at 3 mg, well below the 50 mg that eased tiredness in women with premenstrual symptoms [4]. A 3-year trial of low-dose B vitamins including 3 mg of B6 did not improve quality of life [5]. Vitamin B12 did not boost energy in people who were not deficient [6], and a mix containing it did not change fatigue in dialysis patients [7]. Calcium is a trace 18 mg, far below the 1000 mg a day that reduced tiredness in one premenstrual trial [8]. Animal and cell studies are never counted.

See all 60 studies →Hide the studies

Review Totals and Summary

Members Only3,000 reviews · 90% positive
3,000 reviews · Google Shopping 3,000
90% positive0% neutral10% negative

Buyers are split. The few who like it praise the flavor and a clean energy lift, but most reviews are about powder that arrived clumped, hard or moist, which suggests a storage or freshness problem with some sellers. **What buyers say it did for them:** The happy reviewers describe a noticeable boost in energy without side effects. One says it gives "a safe caffeine boost with no jitters or racing heart." Another says "I work out with explosive energy! My bike rides improve." A third calls it "High quality and worth the price for the benefit!" **What they complain about:** The main complaint is the condition of the powder. Several buyers got tubs with hard clumps or moisture. One says "the powder was all clumpy and on the bottom half of the powder was rock hard." Another ordered three containers and found the same problem in each: "1st one was moist and stuck together instead of being a full powder." Some suspect old stock or poor storage by the seller. One buyer wrote "Old, clumped rock hard," and another noted a returned set of jars that looked unopened. One reviewer also reported an expiration date that made them think the product had sat in a warehouse. Several asked for refunds or said they were returning the product. **Taste, smell and form:** Taste divides reviewers. One says "It's got great flavor," and another says "Taste great too!" A third says "The flavor is terrible," though that review also mentions clumping, so the bad batch may have affected it. Clumping is the main issue with the form. One buyer had to break the powder up by hand before using it. One review concerned a watermelon powder rather than strawberry lemonade, so its comments are only loosely relevant. Reviews of other forms of the product, such as gummies and capsules, were left out. **Value for money:** Only one review speaks directly to value, and it is positive: "worth the price for the benefit." Another buyer enjoyed the single-serve packets enough to buy a canister on a deal. Buyers who received clumped tubs felt they had not got what they paid for. One said "it's unacceptable I would like my money back." One buyer who had bought the product elsewhere said it had never been this poor in quality. **Who it seems to suit and who it did not:** The product seems to suit people who want a pre-workout for energy during exercise and who tolerate caffeine well. Those reviewers were happy with the effect and flavor. It did not suit buyers who got a damaged or old tub. Several reviewers advise caution about where to buy. One says "buy it from Walmart, not third party sellers," and another says they stopped buying pre-workout from third-party sellers after repeated bad experiences. If you do buy it, check the seller, check the expiration date, and look closely at the powder on arrival. A fresh tub looks to be a very different experience from the clumped ones described.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Vitamin B12 is the main ingredient, and the panel leans toward it: four of the ten recommend it, mainly for brain function, mood, nerve protection, and fixing a deficiency, and two more use it. One suggests a liposomal and micellar methylcobalamin form for better absorption, another advises keeping blood levels around 500, and one advises testing first and supplementing only if low. Two panelists were neutral, noting that a deficiency can cause fatigue or hair loss, and one warns that B12 should not be taken too close to bedtime because it enhances light's melatonin-suppressing effects. Vitamin B6 also counts as a main ingredient: one panelist uses it and recommends it with folate and B12 for PMS, one avoids it because too much can damage nerves, and one lists the synthetic pyridoxine form as something to avoid. Calcium and niacin are smaller ingredients in this product, with calcium mostly recommended for bones.

See all 10 biohackers →Hide the biohackers
  • Thomas DeLauer · Vitamin B12 · recommends
    • 18 Oct 2026 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 18 Sep 2026 · Calcium · neutral · Facebook ↗
      Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 12 Aug 2026 · Calcium · recommends · YouTube ↗
      Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
    • 30 Jun 2026 · neutral · YouTube ↗
      Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
    • 30 Jun 2026 · Calcium · neutral · YouTube ↗
      Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
    • 29 Jun 2026 · recommends · YouTube ↗
      Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
    • 24 Jun 2026 · Niacin · neutral · YouTube ↗
      Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
    • 19 Jun 2026 · Calcium · neutral · YouTube ↗
      Mentions that magnesium and calcium should not be taken together as they cancel each other out.
    • 13 Jun 2026 · Calcium · warns · YouTube ↗
      Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
    • 12 Jun 2026 · Calcium · recommends · YouTube ↗
      Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
    • 20 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
    • 20 May 2026 · Calcium · warns · YouTube ↗
      Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
    • 7 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends vitamin B6 to support GABA production and find balance for mental clarity.
  • Dr. Eric Berg · Vitamin B6 · warns
    • 10 Oct 2026 · warns · Podcast ↗
      Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
    • 25 Oct 2026 · Calcium · warns · YouTube ↗
      Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
    • 19 Oct 2026 · Niacin · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 11 Oct 2026 · Niacin · recommends · YouTube ↗
      Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
    • 10 Oct 2026 · Calcium · warns · Podcast ↗
      Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
    • 4 Oct 2026 · recommends · Facebook ↗
      Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
    • 4 Oct 2026 · neutral · X ↗
      Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 4 Oct 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
    • 4 Oct 2026 · Vitamin B12 · neutral · X ↗
      Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 3 Oct 2026 · Calcium · warns · YouTube ↗
      Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
    • 2 Oct 2026 · Niacin · recommends · YouTube ↗
      States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
    • 27 Sep 2026 · Calcium · neutral · X ↗
      Notes that tannins in tea bind calcium, blocking its absorption.
    • 27 Sep 2026 · Niacin · neutral · X ↗
      Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
    • 20 Sep 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking vitamin B12 if on a med.
  • Dr. Mark Hyman · Vitamin B6 · uses
    • 31 Aug 2026 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 30 Sep 2026 · Niacin · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 20 Aug 2026 · Calcium · recommends · YouTube ↗
      Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
    • 22 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 is a nutritional deficiency that impacts mental health.
    • 29 Jun 2026 · recommends · Facebook ↗
      Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
    • 29 Jun 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
    • 17 Jun 2026 · Calcium · neutral · YouTube ↗
      States that green leafy vegetables are great sources of calcium.
    • 3 Jun 2026 · neutral · YouTube ↗
      Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
    • 3 Jun 2026 · Vitamin B12 · recommends · YouTube ↗
      Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
    • 18 Apr 2026 · Vitamin B12 · neutral · Facebook ↗
      Lists Vitamin B12 as important for nerve health and energy.
    • 3 Nov 2025 · Calcium · neutral · Podcast ↗
      Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
    • 8 Oct 2025 · Niacin · neutral · YouTube ↗
      Lists niacin as a B vitamin cofactor that helps mitochondrial function.
    • 17 Sep 2025 · Calcium · warns · YouTube ↗
      Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
    • 14 May 2025 · Calcium · warns · YouTube ↗
      Warns that acid blockers inhibit calcium absorption.
  • Ben Greenfield · Vitamin B12 · recommends
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 9 May 2026 · Calcium · neutral · YouTube ↗
      Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
    • 6 May 2026 · Calcium · neutral · X ↗
      Mentions calcium as a common deficiency.
    • 25 Apr 2026 · Niacin · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 18 Apr 2026 · Niacin · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
    • 12 Apr 2026 · Calcium · recommends · Facebook ↗
      Recommends adequate intake of calcium for bone strength.
    • 13 Feb 2026 · Calcium · uses · YouTube ↗
      Is using calcium chloride mixed with PRP before injecting for the P-shot.
    • 8 Jan 2026 · Niacin · neutral · YouTube ↗
      Mentions niacin as a natural approach that might be good for plaque regression.
    • 22 Nov 2025 · Calcium · stopped · YouTube ↗
      Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
    • 30 Sep 2025 · Niacin · recommends · Facebook ↗
      Notes that 10X Health System's methylene blue tablets plus light stack supports energy and recovery at the cellular level by promoting healthy metabolism through niacinamide.
    • 25 Sep 2025 · Niacin · uses · Facebook ↗
      Uses Niacinamide as a clean building block for NAD+ as part of NAD Regen.
    • 21 Aug 2025 · Calcium · warns · Facebook ↗
      Warns that in high doses, calcium without the right cofactors can raise cardiovascular risk by contributing to arterial calcification instead of bone strength, and may increase the risk of osteoporosis.
    • 14 Aug 2025 · Niacin · recommends · YouTube ↗
      Recommends priming the skin with niacinamide to reduce hyperpigmentation, noting its effectiveness in reducing hyperpigmentation by 50% in an ex-girlfriend's laser burn.
  • Dave Asprey · Vitamin B12 · recommends
    • 1 Jul 2026 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 16 Jun 2026 · Calcium · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
    • 12 Jun 2026 · Calcium · neutral · Instagram ↗
      Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
    • 12 Jun 2026 · Calcium · neutral · X ↗
      Notes that people take calcium for their bones.
    • 30 May 2026 · Niacin · recommends · YouTube ↗
      Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
    • 15 May 2026 · Niacin · neutral · X ↗
      Notes that niacin has been a standard longevity ingredient since the 1990s.
    • 14 May 2026 · Calcium · warns · YouTube ↗
      Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
    • 17 Feb 2026 · Niacin · neutral · Podcast ↗
      Dave discusses how niacinamide compares as an NAD precursor.
    • 17 Feb 2026 · Niacin · neutral · YouTube ↗
      Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
    • 10 Feb 2026 · Niacin · stopped · YouTube ↗
      Used niacin for a while to address plaque in his arteries and high LP(a), but stopped because it caused high liver values and made him feel unwell, despite dropping his LP(a).
    • 1 Jan 2026 · Vitamin B6 · neutral · YouTube ↗
      Mentions Vitamin B6 as playing a role in methylation pathways.
    • 30 Dec 2025 · Calcium · recommends · YouTube ↗
      Recommends taking calcium citrate during a high oxalate meal to bind the oxalate in the gut.
    • 21 Oct 2025 · Calcium · neutral · YouTube ↗
      Notes that people often take calcium for bone health.
  • Siim Land · Vitamin B12 · uses
    • 24 Apr 2026 · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 14 Aug 2026 · Calcium · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 24 Mar 2026 · recommends · YouTube ↗
      States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
    • 15 Feb 2026 · Niacin · recommends · TikTok ↗
      Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
    • 14 Feb 2026 · Calcium · recommends · TikTok ↗
      Recommends a high calcium intake for bone health.
    • 12 Feb 2026 · Niacin · recommends · Instagram ↗
      Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
    • 17 Jan 2026 · Niacin · neutral · Instagram ↗
      Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
    • 28 Dec 2025 · Calcium · warns · YouTube ↗
      Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
    • 28 Dec 2025 · Niacin · neutral · YouTube ↗
      Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
    • 11 Dec 2025 · Niacin · recommends · YouTube ↗
      Recommends niacin as a much cheaper and equally effective NAD booster compared to NMN and NR.
    • 25 Oct 2025 · Niacin · warns · Instagram ↗
      Warns that niacin, an NAD precursor, can shorten sleep.
    • 18 Oct 2025 · Niacin · recommends · YouTube ↗
      Recommends taking 100-300 milligrams of niacin before a sauna session, as part of the Hubert protocol, to enhance sweating, vasodilation, and potentially detoxification and cardiovascular benefits.
    • 16 Oct 2025 · Niacin · warns · YouTube ↗
      Warns that Niacin, especially at high doses like 2000 mg per day, can disrupt sleep by increasing energy levels too high, causing flushing, and reducing deep sleep while increasing shallow non-REM sleep.
  • Andrew Huberman · Vitamin B12 · neutral
    • 15 Dec 2025 · neutral · YouTube ↗
      States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
    • 7 Oct 2024 · recommends · YouTube ↗
      Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
    • 29 Jul 2024 · uses · YouTube ↗
      Has been taking AG1 for over 10 years, once and often twice every day, to ensure he gets all necessary vitamins, minerals, probiotics, and adaptogens, considering it a nutritional insurance policy.
    • 29 Jul 2024 · Vitamin B6 · warns · YouTube ↗
      Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
    • 1 Jul 2024 · Niacin · neutral · Instagram ↗
      Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
    • 1 Jul 2024 · Niacin · recommends · YouTube ↗
      Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
    • 24 Apr 2024 · recommends · YouTube ↗
      Has been taking AG1 since 2012 to ensure he gets enough vitamins, minerals, Prebiotic fiber, and other nutrients typically found in fruits and vegetables, providing nutritional insurance.
    • 23 Oct 2023 · uses · YouTube ↗
      Andrew Huberman started drinking AG1 in 2012 and still drinks it once or twice a day because it provides all his foundational nutritional needs, ensuring proper amounts of vitamins, minerals, probiotics, and fiber for optimal mental health, physical health, and performance.
    • 12 Jun 2023 · Vitamin B6 · neutral · YouTube ↗
      Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
    • 6 Mar 2023 · Calcium · neutral · Podcast ↗
      Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
    • 22 Aug 2022 · recommends · YouTube ↗
      Recommends the consumption of B12 and other B vitamins, especially folate, as it has been shown to partially decrease cancer risk in people who ingest alcohol, though it does not completely offset it.
    • 18 Apr 2022 · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it once or twice a day because it covers foundational vitamin, mineral, and probiotic needs, and supports immune system function and a healthy gut microbiome.
    • 11 Apr 2022 · Vitamin B6 · recommends · YouTube ↗
      Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
    • 17 May 2021 · uses · YouTube ↗
      He has been using Athletic Greens for over a decade to cover his vitamin and mineral bases and support his gut microbiome, immune system, gut-brain axis, and mental functions.
  • Dr. Rhonda Patrick · Vitamin B12 · warns
    • 8 Oct 2025 · warns · Facebook ↗
      Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 9 Jan 2026 · Calcium · neutral · Facebook ↗
      Notes additional gaps in calcium.
    • 3 Jul 2024 · Calcium · warns · YouTube ↗
      Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
    • 28 Jan 2020 · Niacin · neutral · YouTube ↗
      States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
    • 9 Apr 2016 · recommends · YouTube ↗
      Notes that a med can cause vitamin B12 deficiency, especially as absorption decreases with age, and suggests a sublingual form or B12 injections for older individuals.
    • 23 Jan 2016 · uses · YouTube ↗
      Discusses the origin of Vitamin B12, suggesting it's a microorganism that propagates in the soil and that animals get it from eating dirt, which is why it's less available in modern, sanitized plant foods.
    • 9 Oct 2015 · Calcium · neutral · YouTube ↗
      Around 38% doesn't meet the requirement for calcium.
    • 19 Mar 2015 · Vitamin B6 · recommends · YouTube ↗
      Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
    • 11 Feb 2015 · Calcium · uses · YouTube ↗
      Takes a calcium-magnesium pill because he believes people tend to be short of both and that the body cares about the ratio of these similar molecules.
    • 22 Jun 2014 · Vitamin B6 · recommends · YouTube ↗
      Vitamin B6 can suppress the production of Advanced Glycation End products.
    • 17 Feb 2014 · recommends · YouTube ↗
      Describes a study where female mice fed a diet high in B vitamins, folic acid, and vitamin B12 three weeks before pregnancy had offspring that no longer had yellow fur and were not predisposed to obesity and cancer.
    • Date not recorded · neutral · Website ↗
      Dr. Rhonda Patrick explores vitamin B12 and autism risk.
    • Date not recorded · uses · Website ↗
      She takes methyl B12 as part of her Thorne multivitamin, which helps keep her homocysteine levels below 9 micromoles per liter.
  • Bryan Johnson · Vitamin B12 · uses
    • 5 Jun 2025 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
    • 5 Jun 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 12 May 2025 · Calcium · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
    • Date not recorded · Calcium · recommends · Website ↗
      Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
    • Date not recorded · Calcium · uses · Website ↗
      Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
    • Date not recorded · Calcium · recommends · Source ↗
      Recommends continuing with calcium to support bone health during the follicular phase.
    • Date not recorded · Niacin · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • Date not recorded · Niacin · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
  • Peter Attia · Vitamin B12 · neutral
    • 9 Sep 2024 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 22 Oct 2024 · Calcium · recommends · YouTube ↗
      Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
    • 21 Oct 2024 · Calcium · recommends · YouTube ↗
      Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
    • 30 Jan 2023 · Niacin · stopped · YouTube ↗
      Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
    • 7 Nov 2022 · Niacin · stopped · YouTube ↗
      Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
    • 1 Aug 2022 · Niacin · neutral · YouTube ↗
      Recalls that a flush from niacin typically occurred with doses of a few grams.
    • 18 Jul 2022 · Calcium · neutral · YouTube ↗
      Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
    • 13 Jun 2022 · Niacin · warns · YouTube ↗
      Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
    • 13 Jun 2022 · Niacin · neutral · Podcast ↗
      He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
    • 26 Oct 2020 · Calcium · recommends · YouTube ↗
      Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
    • 21 Sep 2020 · Niacin · warns · YouTube ↗
      States that niacin is a dead drug and is not recommended by any guidelines, though some still selectively use it for Lp(a).

RAL Summary

Members OnlyTier 3 for Energy

Tier 3 rests on reviews: 3000 counted with 90% positive. Study support is thin, because the label vitamins showed no energy benefit and no studies were given for the main blend [1][6].

  • Calcium: trace amount

Where the evidence disagrees: 33 of the 60 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Metabolic system, Cardiovascular system

Combine with: Because this product is a stimulant-based energy and thermogenic formula, it should not be relied on for regularity. For long-term bowel regularity, consider pairing a different regimen with soluble fiber such as psyllium husk or partially hydrolyzed guar gum, magnesium citrate or magnesium oxide for gentle osmotic support, and a probiotic with strains like Bifidobacterium lactis BB-12 or Lactobacillus rhamnosus GG. Adequate water intake, and optionally prunes or sorbitol-rich foods, also help. If you continue using Super HD for energy, take it earlier in the day with plenty of water, and pair it with L-theanine to smooth out caffeine's jitteriness and with electrolytes to support hydration. Check with a healthcare provider if constipation is persistent or you take medications.

Possible side effects: Studies note that niacin can cause flushing, stomach upset, fatigue and liver problems, mostly at doses far higher than in this product. No written reviews were read for side effects.

Supplement Facts

Total Carbohydrates 4 g · Niacin 10 mg · Vitamin B6 3 mg
Supplement Facts
Serving Size 1 Scoop(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Calories10
Total Carbohydrates4 g
Niacin10 mg
Vitamin B63 mg
Vitamin B12250 mcg
Calcium18 mg
SuperHD Thermo-Sensory Blend (Combination)521 mg†
† Daily Value not established.

Other ingredients: Polydextrose, Natural and Artificial flavors, Malic Acid, Citric Acid, Calcium Silicate, Sucralose, Silicon Dioxide, FD&C Red Lake #40, Acesulfame Potassium, Xanthan Gum.

Barcode (UPC) 810390024858 · Label source: NIH label database · Report a label change

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Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.