Garden of Life Dr. Formulated CBD 50 mg Liquid Drops Chocolate Mint Review
Garden of Life Dr. Formulated CBD 50 mg Liquid Drops in Chocolate Mint is an oral hemp-extract dietary supplement. It was developed with neurologist David Perlmutter, MD. The retailer listing describes it as vegan, gluten free, non-GMO tested, THC free and made with a CO2 solvent-free extract. Each 1 mL serving supplies 50 mg of cannabidiol (CBD), and a bottle holds 30 servings. The label lists a broad spectrum hemp extract blend, organic peppermint oil and organic spearmint oil, an "Entourage Effect Blend", and organic chocolate mint flavor. The brand says it is made without dairy, soy, peanut or shellfish ingredients, and without artificial colors or preservatives. The product is "broad spectrum". That means it keeps the terpenes, cannabinoids, flavonoids and fatty acids found in full spectrum CBD, but without THC. The aim is an "entourage effect", where several hemp compounds together may act differently from CBD alone. This is a hypothesis that is still debated. It has not been firmly proven in humans for this product. Mechanism of action: CBD does not bind strongly to the CB1 receptor, so it is not intoxicating. Research suggests it works indirectly. It modulates the endocannabinoid system, partly by slowing the breakdown of the endocannabinoid anandamide. It also interacts with serotonin 5-HT1A receptors, TRPV1 channels and other signaling pathways involved in stress response, inflammation, and sleep. The drops are taken under the tongue or swallowed. Sublingual use may give somewhat faster uptake than capsules, though oral CBD bioavailability is generally low and varies from person to person. Fat in the carrier oil helps absorption. The peppermint and spearmint oils mainly add flavor and terpene content. Quality data: Labdoor's independent test found 52.7 mg of CBD per bottle against 50 mg claimed. THC, lead, arsenic, cadmium and mercury were below the limit of quantification, and yeast, mold and coliforms were 0 cfu/g. Labdoor also notes that the product's certification has expired. Safety: CBD can interact with medications processed by liver enzymes, so people taking meds should consult a clinician. Pregnant or nursing women should avoid it. Effects are not guaranteed, and this product is not intended to diagnose, treat or cure any disease.
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Study, Trial or Testing Result Summary
Members Only81 human studies · 30 improved
1 of these 81 human studies gave the ingredient by inhaler, not by mouth.
The evidence on cannabidiol, the main calming compound in hemp extract, is mixed for stress and calm. A review of eight studies with 316 people found it clearly reduced anxiety, though the samples were small [1]. A 15-week placebo-controlled trial in 178 adults with mild to moderate anxiety found less anxiety than placebo [2]. Single doses of 300 to 600 milligrams eased anxiety during a public speaking test [3][4]. However, a large review of 54 trials found no clear effect on anxiety [5]. In healthy adults, 100 milligrams daily for 12 weeks did not change stress or mood [6], and a single 300 milligram dose did not lower anxiety in students [7]. A review of brain imaging studies found no consistent effect [8]. This product lists 945 milligrams of hemp extract, but the store listing says that holds about 50 milligrams of cannabidiol per serving, well below the 300 to 600 milligram single doses that helped in trials [3][4]. The 3 milligram entourage blend is far below the studied amount and its contents are hidden in a blend. Animal and cell studies are never counted.
See all 81 studies →Hide the studies
- Across 152 trials with 12,123 people, cannabidiol clearly helped epilepsy and Parkinsonism, and other cannabinoids helped pain, sleep and appetite, but most other effects had low or very low quality evidence, and anxiety was not highlighted as improved.Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.
- In 40 randomised trials with 3,067 people, THC with or without CBD gave a small anxiety improvement in people with other medical conditions (very low quality evidence), but did not help other mental disorders and caused more side effects.Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analys…
- In 54 trials with 2,477 people, cannabinoids had no significant effects on anxiety outcomes, though they helped some other conditions such as insomnia, and they raised the odds of side effects.The efficacy and safety of cannabinoids for the treatment of mental disorders and substance use disorders: a systematic …
- Across eight studies with 316 people, cannabidiol significantly reduced anxiety with a large effect size, though the authors warn the sample was small.Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis.
- In a review of six case reports and seven trials with 201 people, most studies did not reach statistical significance, with limited evidence of benefit for anxiety in social anxiety disorder and mild side effects like sedation.Is there a role for cannabidiol in psychiatry?
- A review of 12 brain imaging studies with 146 adults found no consistent effect of cannabidiol on brain activity during stress or anxiety, with low to very low certainty of evidence.Functional neuroimaging of Cannabidiol in stress and anxiety: a systematic review.
- In a review of 35 studies across 13 conditions, 23 reported significant improvement in main outcomes such as anxiety, psychotic symptoms and seizures at doses from under 1 to 50 mg per kg daily, while small trials of other conditions showed no benefit.A systematic review of cannabidiol dosing in clinical populations.
- A review of 27 trials found limited evidence for cannabidiol in psychiatric disorders, with some possible benefits for anxiety, psychosis and substance use.Cannabidiol (CBD) use in psychiatric disorders: A systematic review.
- A review of eight small studies found cannabidiol at single doses of 6 to 400 mg improved anxiety scores and was generally well tolerated, with fatigue and sedation the most common side effects.Use of cannabidiol in anxiety and anxiety-related disorders.
- A review of case studies and trials in psychiatric conditions found tentative support for cannabidiol in reducing social anxiety, but evidence overall was weak and early, so the authors said it is premature to recommend it.Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review.
- A review of nine studies in people with autism found cannabis products reduced symptoms such as anxiety, restlessness, irritability and sleep problems, but the authors say blinded placebo-controlled trials are still needed.Cannabis and cannabinoid use in autism spectrum disorder: a systematic review.
- A review of 49 controlled studies found high doses of cannabidiol gave some short-term relief of anxiety, but no study showed lasting benefit and products with THC carried more side effects.The differential effects of medicinal cannabis on mental health: A systematic review.
- A review of treatments for anxiety that had not responded to usual care found only preliminary evidence from open label studies for cannabidiol, among many other options.Integrative Systematic Review on Pharmacological, Psychotherapeutic, and Neurostimulatory Treatment Options in Treatment…
- A review of eight very small trials found single doses of cannabidiol reduced anxiety in lab tests and 4 weeks of daily use gave modest benefit in teens with social anxiety, but evidence was insufficient overall.Evidence for Use of Cannabinoids in Mood Disorders, Anxiety Disorders, and PTSD: A Systematic Review.
- A review of five small studies in children with cancer in palliative care found benefits for massage and Reiki on pain and anxiety symptoms, but not for cannabis.Effectiveness of complementary therapies for the management of symptom clusters in palliative care in pediatric oncology…
- A review of 58 randomized trials, mostly small, found cannabidiol appears to reduce anxiety, but its effects on other conditions were highly variable.The Effectiveness and Safety of Cannabidiol in Non-seizure-related Indications: A Systematic Review of Published Randomi…
- In a placebo-controlled trial of 178 adults with mild to moderate anxiety, 15 weeks of nanodispersible cannabidiol reduced anxiety scores more than placebo, with no serious adverse events.Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus…
- In 159 regular cannabis users, a single session of a cannabis flower containing roughly equal THC and CBD produced less paranoia and anxiety than a THC-dominant flower, with similar positive mood effects.Effects of cannabidiol in cannabis flower: Implications for harm reduction.
- In a placebo-controlled trial of 150 children and young people with autism, 12 weeks of whole-plant cannabis extract left the main home behaviour score unchanged, but 49% were much or very much improved on clinician ratings versus 21% on placebo, and the treatment was well tolerated.Cannabinoid treatment for autism: a proof-of-concept randomized trial.
- In a double-blind placebo-controlled trial of 136 people with hand osteoarthritis or psoriatic arthritis, 20 to 30 mg of synthetic cannabidiol daily for 12 weeks did not change pain, sleep, depression, anxiety or pain catastrophizing compared with placebo.Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled tri…
- In 80 adults with social anxiety or panic disorder receiving eight weeks of exposure therapy, adding 300 mg of cannabidiol daily did not improve fear outcomes compared with placebo.Cannabidiol enhancement of exposure therapy in treatment refractory patients with social anxiety disorder and panic diso…
- In 78 adults with cocaine use disorder, up to 800 mg of cannabidiol daily for about 12 weeks did not reduce anxiety or cortisol stress response more than placebo.Cannabidiol Effect on Anxiety Symptoms and Stress Response in Individuals With Cocaine Use Disorder: Exploratory Results…
- In 65 overweight adults taking a hemp oil extract with 15 mg of cannabidiol daily for six weeks, there were no statistically significant between-group improvements in stress resilience; only trends toward better coping and enjoyment of life were seen, alongside within-group sleep improvements.Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overwei…
- In a placebo-controlled trial of 60 children aged 5 to 11 with autism, 12 weeks of cannabidiol-rich cannabis extract improved social interaction, anxiety and agitation compared with placebo, with few side effects.Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: ra…
- In a single 140-minute session with 54 healthy young adults who drink caffeine daily, cannabidiol doses of 25 to 240 mg taken with 200 mg caffeine did not change self-reported drug effects or anxiety compared with placebo, and no negative effects appeared.A preliminary investigation of the simultaneous effects of cannabidiol and caffeine.
- In 54 healthy adults, 100 mg of cannabidiol daily for 12 weeks did not change perceived stress, sleep, or mood versus placebo, though pain rose less in the cannabidiol group.The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcom…
- In 51 adults with cannabis dependence, a 6-day course of nabiximols reduced overall cannabis withdrawal severity compared with placebo and gave a smaller benefit for anxiety.Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial.
- In 51 people with Parkinson's disease, 26 mg a day of sublingual cannabidiol for 12 weeks did not improve delayed recall compared with placebo, but it improved naming test scores.Cannabidiol and cognitive functions/inflammatory markers in Parkinson's disease: A double-blind randomized controlled tr…
- In 50 women with advanced breast cancer and anxiety, a single 400 mg dose of cannabidiol before a scan did not beat placebo on the main anxiety measure, but anxiety scores were lower 2 to 4 hours after the dose.Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer: A Randomized Clinical Trial.
- In 48 healthy people, a single 32 mg dose of cannabidiol given after fear extinction training strengthened memory of that extinction, as shown by lower expected shocks compared with placebo.Cannabidiol enhances consolidation of explicit fear extinction in humans.
- In 42 trauma-exposed adults taking 300 mg of cannabidiol daily for one week, cannabidiol did not reduce anxiety, distress, or heart rate during trauma recall compared with placebo.The effects of acute versus repeated cannabidiol administration on trauma-relevant emotional reactivity: A double-blind,…
- In 40 healthy young adults, a single 300 mg dose of cannabidiol did not change self-reported anxiety compared with placebo, but it slowed attention lapses on a vigilance test and increased early responses on a reaction time test.The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized cli…
- In 35 adults with bipolar depression, adding cannabidiol at 150 to 300 mg daily for eight weeks did not improve depression scores more than placebo, though an exploratory analysis hinted at benefit at 300 mg.Cannabidiol as an Adjunctive Treatment for Acute Bipolar Depression: A Pilot Study: Le cannabidiol comme traitement d'ap…
- In 33 people at clinical high risk for psychosis, a single 600 mg dose of cannabidiol did not change the link between social stress cortisol response and brain fear processing compared with placebo.Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in peo…
- In 33 adults with posttraumatic stress disorder given a single 300 mg dose of cannabidiol before recalling a trauma, cannabidiol reduced the rise in cognitive impairment but not anxiety compared with placebo.Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disor…
- In 33 adults with posttraumatic stress disorder given a single 300 mg dose before recalling a trauma, cannabidiol reduced anxiety and cognitive impairment only in those whose trauma was nonsexual, not in those with sexual trauma.The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disord…
- In 32 healthy volunteers with high paranoid traits, a single 600 mg oral dose of cannabidiol taken before a virtual-reality stress task did not reduce anxiety, cortisol, heart rate or persecutory thoughts compared with placebo, and anxiety showed a non-significant trend upward.The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group.
- In 32 college students with test anxiety, single doses of 150, 300, or 600 mg of cannabidiol did not reduce test anxiety or general anxiety compared with placebo.A Double-Blind, Randomized, Placebo-Controlled Test of the Effects of Cannabidiol on Experiences of Test Anxiety Among C…
- In 31 men with crack-cocaine dependence, 300 mg of cannabidiol daily for 10 days did not reduce craving or withdrawal symptoms more than placebo.Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study.
- In 30 adults with primary insomnia, 150 mg of cannabidiol taken nightly for two weeks did not change most sleep measures compared with placebo, but it raised well-being scores and improved sleep efficiency after two weeks.Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing.
- In 29 autistic children, 12 weeks of CBD oil did not improve the main social responsiveness score compared with placebo, but it reduced anxiety on one secondary rating scale and lowered parental stress.Effects of Cannabidiol on Social Relating, Anxiety, and Parental Stress in Autistic Children: A Randomized Controlled Cr…
- In 26 healthy recreational cannabis users, a single dose of vaporised cannabis with equal THC and CBD caused less state anxiety than THC-dominant cannabis, though THC/CBD still increased anxiety compared with placebo.Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less s…
- In 24 treatment-naive adults with social anxiety disorder, a single 600 mg dose of CBD taken before a simulated public speaking test reduced anxiety compared with placebo.Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.
- In a crossover trial of 24 people with Parkinson's disease, a single 300 mg dose of cannabidiol reduced anxiety during a simulated public speaking test compared with placebo, and also reduced hand tremor amplitude.Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patien…
- In a crossover placebo-controlled study of 24 healthy adults, a single 600 mg oral dose of cannabidiol did not change brain responses to emotional faces or anxiety caused by a stress task compared with placebo.The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study.
- In 24 adults with fibromyalgia taking a 1:1 THC to cannabidiol oil for 16 weeks, anxiety and depression did not change significantly compared with placebo, though pain and sleep improved.Feasibility, Safety and Preliminary Efficacy of 1:1 THC:CBD Cannabis Oil for Fibromyalgia Symptoms: Results From a Rando…
- In 17 healthy volunteers given 600 mg of cannabidiol before ayahuasca, there was no difference from placebo in emotion recognition, empathy, anxiety, or sedation over one week.Interactive Effects of Ayahuasca and Cannabidiol in Social Cognition in Healthy Volunteers: A Pilot, Proof-of-Concept, F…
- In 15 healthy men, a single 600 mg dose of CBD showed a trend toward reduced anxiety and lower brain and skin-conductance responses to fearful faces, while a 10 mg THC dose increased anxiety.Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing.
- In 15 healthy adults given a single 600 mg dose of cannabidiol, brain imaging showed reduced connection between the amygdala and anterior cingulate when viewing fearful faces, a pattern linked to anxiety reduction.Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol.
- In 15 healthy men, a single 600 mg dose of cannabidiol had no significant effect on anxiety, psychotic symptoms or sedation compared with placebo, while 10 mg of THC increased anxiety.Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the…
- In 14 healthy volunteers, a single 10 mg THC dose increased anxiety and psychotic symptoms, while a single 600 mg CBD dose had no significant effect on symptoms.Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study.
- In 12 adults with obsessive-compulsive disorder, single sessions of smoked THC or CBD cannabis did not change OCD symptoms more than placebo and produced smaller drops in anxiety than placebo.Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study.
- In a placebo-controlled crossover trial of 12 adults with Tourette syndrome, a single 5 to 10 mg dose of delta9-THC did not affect most cognitive tests but worsened obsessive-compulsive symptoms and showed a trend toward more phobic anxiety; this study did not test cannabidiol.Influence of treatment of Tourette syndrome with delta9-tetrahydrocannabinol (delta9-THC) on neuropsychological performa…
- In 10 healthy men, a single 400 mg dose of cannabidiol reduced self-rated anxiety more than placebo and changed brain blood flow in areas linked to fear.Effects of cannabidiol (CBD) on regional cerebral blood flow.
- In nine cannabis smokers given single doses over 10.5 hours, cannabidiol in Sativex did not reduce the anxiety or heart rate effects of THC compared with oral THC alone, and both produced similar small increases in anxiety.Subjective and physiological effects after controlled Sativex and oral THC administration.
- In two postmenopausal women with osteopenia, 12 weeks of twice-daily oral CBD showed no notable change in sleep, depression, anxiety, stress, or quality of life.Oral Cannabidiol Treatment in Two Postmenopausal Women with Osteopenia: A Case Series.
- In a double-blind trial of people having root canal treatment, a single oral dose of cannabidiol-rich cannabis extract did not reduce dental anxiety more than placebo, and anxiety scores were actually higher in the cannabidiol group; postoperative pain also did not differ over 7 days.Effect of Preoperative Oral Cannabidiol-Rich Cannabis Extract on Anxiety and Postoperative Pain after Endodontic Treatme…
- In 300 adults with anxiety symptoms, using cannabidiol-dominant cannabis flower over 4 weeks was linked to lower anxiety scores than high-THC flower, though participants were not randomly assigned to placebo.Acute and Extended Anxiolytic Effects of Cannabidiol in Cannabis Flower: A Quasi-Experimental ad libitum Use Study.
- In 22 adults with severe Tourette syndrome, a 6-week course of an oral THC and CBD oil reduced tics compared with placebo and may have reduced anxiety, but some participants reported slowed thinking, memory lapses, and poor concentration.Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome.
- In 12 runners given a single 300 mg dose of cannabidiol or placebo on separate visits, cannabidiol increased feelings of calm and relaxation before a two-mile run without changing run time.The Effects of an Acute Dose of Cannabidiol on Health and Two-Mile Time Trial Performance-A Pilot Study.
- In 8 healthy volunteers, a single dose of cannabidiol at 1 mg/kg blocked the anxiety caused by tetrahydrocannabinol, though it also reduced other marijuana-like effects.Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.
- In 40 patients with chronic conditions, a single session of prescribed medical cannabis had little acute effect on thinking tests, with some scores improving and others unchanged; there was no placebo group.A Semi-Naturalistic, Open-Label Trial Examining the Effect of Prescribed Medical Cannabis on Neurocognitive Performance.
- In an open-label study, 33 people taking 160 mg or 320 mg of cannabidiol softgels twice a day during symptom days for three months had lower anxiety, irritability, stress and overall menstrual symptoms compared with baseline, but there was no placebo group.Examination of the effects of cannabidiol on menstrual-related symptoms.
- In 31 young people with treatment-resistant anxiety disorders, 12 weeks of add-on CBD, titrated up to 800 mg per day, lowered anxiety severity scores by about 43%, with no serious adverse events.Cannabidiol for Treatment-Resistant Anxiety Disorders in Young People: An Open-Label Trial.
- In 17 people with burning mouth syndrome, a cannabis plant oil taken for four weeks was followed by reduced mouth pain and improved anxiety and depression scores in an open-label study without a placebo group.Evaluating the Suitability and Potential Efficiency of Cannabis sativa Oil for Patients with Primary Burning Mouth Syndr…
- In an open-label feasibility study of 15 people with hand arthritis, a 4% cannabidiol gel applied three times a day for four weeks was linked to lower pain, better grip strength and less fatigue, stiffness and anxiety, but there was no placebo group and effects faded during washout.An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis.
- In an open-label study of 14 adults with moderate-to-severe anxiety, a full-spectrum high-CBD solution taken three times daily for four weeks reduced anxiety, with 78.6% of patients reaching a clinically meaningful response on the Beck Anxiety Inventory by week 1, and executive function improved; there was no placebo group.Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from…
- In 10 people with Sturge-Weber syndrome, six months of oral CBD at 5 to 20 mg/kg per day significantly improved anxiety and emotional regulation, and the drug was generally well tolerated.Cannabidiol Treatment for Neurological, Cognitive, and Psychiatric Symptoms in Sturge-Weber Syndrome.
- In a national survey of 1,523 US adults, about 35% had ever used CBD, and anxiety was among the most common medical reasons given, but the survey did not measure whether it worked.Prevalence and reasons for using cannabidiol, delta-8 tetrahydrocannabinol, cannabinol, cannabigerol, and hexahydrocanna…
- In a survey of women with chronic pelvic pain, 80.9% of current CBD users reported pain improvement, and those who improved also reported better anxiety, sleep, and mood, though this was a cross-sectional survey without a control group.Cannabidiol Use and Perceptions of Effectiveness in Women With Chronic Pelvic Pain.
- In a survey of Parkinson's patients, more than 20% of cannabis users said anxiety improved, though the survey did not use a control group and the dose was not reported.Cannabis in Parkinson's Disease: The Patients' View.
- In a survey of cancer patients, those who used cannabis reported moderate to high relief of symptoms such as pain, nausea, and anxiety, but the survey did not measure anxiety separately or use a control group.Marijuana and Cannabidiol Use Prevalence and Symptom Management Among Patients with Cancer.
- Over 12 months in 585 patients prescribed medical cannabis in Quebec, anxiety improved over time, and patients on CBD-dominant or balanced products improved more for anxiety than those on THC-dominant products.Authorization Patterns, Safety, and Effectiveness of Medical Cannabis in Quebec.
- In an online survey of 141 breast cancer patients, those who used cannabidiol (CBD) reported improvement, most often in insomnia and pain; the survey did not measure stress or calmness directly.Characterizing Cannabidiol Use in a Breast Cancer Population.
- A survey of 101 community pharmacy customers described how people used hemp oil CBD, including 17 people who used it for anxiety, but it did not measure whether anxiety improved.Assessment of hemp oil-based cannabidiol use in a community-based pharmacy setting.
- In a retrospective chart review of 72 adults taking CBD alongside usual treatment, anxiety scores fell within the first month in 79.2% of patients and stayed lower over the study, though there was no control group and the dose and duration were not reported.Cannabidiol in Anxiety and Sleep: A Large Case Series.
- In 70 patients with Tourette's syndrome using medical cannabis for 6 months, quality of life and employment improved, while tics and general mood did not show significant improvement.Use of Medical Cannabis in Patients with Gilles de la Tourette's Syndrome in a Real-World Setting.
- In a parent survey of 18 children with a rare movement disorder, three children were reported to have moderately or significantly less anxiety on cannabis, with no control group and no dose reported.Cannabis Use in Children With Pantothenate Kinase-Associated Neurodegeneration.
- Medical cannabis patients surveyed rated cannabis as highly effective for anxiety, averaging 8 out of 10, though the study did not report the number of patients and had no control group.Cannabis and the Anxiety of Fragmentation-A Systems Approach for Finding an Anxiolytic Cannabis Chemotype.
- Australian prescribing records show medical cannabis is often prescribed for anxiety and sleep conditions, but the records contain no measure of benefit and the authors note that clinical evidence of efficacy is lacking.Medicinal cannabis for psychiatry-related conditions: an overview of current Australian prescribing.
- In 374 people using 1,000 mg CBD oil for 30 or 60 days, both the isolate and broad spectrum products were rated highly effective for helping manage stress, with the broad spectrum product rated somewhat higher; there was no placebo group.Effects of Two Cannabidiol Oil Products on Self-Reported Stress Relief: A Quasi-Experimental Study.
Review Totals and Summary
Members Only110 reviews
I could not find enough verified, product-specific customer reviews to give a reliable picture of feedback on this exact Chocolate Mint 50 mg drop. The pages that carried review-style text were generic, templated articles. They described Garden of Life's CBD line in broad terms and are not trustworthy as individual testimonials. Those pages said users reported reduced inflammation, better sleep, and improved relaxation across the brand's range. Those claims cover several products and are unverified, so they should not be read as evidence about this one. What can be said with more confidence comes from the objective data. The independent lab result showed potency close to the label claim and clean contaminant testing. This is the kind of consistency that buyers of CBD products usually value. The brand's positioning around a physician formulator, a THC-free broad spectrum profile, and a minty chocolate flavor aims to appeal to people who want to avoid THC. Typical themes for flavored CBD drops, which I could not confirm for this SKU, include taste preference, since the hemp flavor may still come through, and uncertainty about how well the product works, because results vary and take time. Price per milligram is also a common concern. For real customer sentiment, check the verified-purchase reviews on Garden of Life's own site, Amazon, Vitacost or iHerb, and the Reddit community r/CBDOilReviews. I could not read these directly.
Biohacker Summary
Members Only3 of 10 recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 4 for Stress and Calm
Studies on cannabidiol for anxiety disagree, with some trials showing benefit [2] and a large review showing none [5], and there are no product reviews to count, so the evidence stays emerging.
- Emerging: not enough evidence to rank higher yet.
- Entourage Effect Blend: below the dose that worked in studies
Where the evidence disagrees: 23 of the 81 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system
Combine with: For stress and calmness, which is the product's real strength, pair it with magnesium glycinate for nervous system relaxation, L-theanine for calm focus without sedation, and ashwagandha (KSM-66 or Sensoril) to help lower cortisol. Taking it with a small amount of dietary fat can improve CBD absorption. If sleep is a concern, add glycine or low-dose melatonin in the evening. If you still want true cellular and DNA repair support, consider a separate regimen of NMN or NR with resveratrol or pterostilbene, plus CoQ10, alpha-lipoic acid, and omega-3s. Check with a healthcare provider first, because CBD can interact with medications metabolized by CYP450 enzymes, such as meds and some meds.
Possible side effects: Reviews of trials found cannabis compounds raised the odds of side effects, and one study saw slightly longer attention lapses after a single dose, though a 15-week trial reported no serious adverse events.
Supplement Facts
Broad Spectrum Hemp extract Blend 945 mg · Entourage Effect Blend 3 mg
| Broad Spectrum Hemp extract Blend | 945 mg | † |
| Entourage Effect Blend | 3 mg | † |
Other ingredients: Organic Chocolate Mint flavor.
Directions: Suggested Use: Adults take 1 dropperful (1 mL) 1 or more times daily as desired.
Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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