Herbalife Nutrition Sleep Now Review
Tier ⓘ
Tier 3 · Rank 17
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 17 within Tier 3 for Blood Pressure; 29 of 53 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
51 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
88% of 54
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only107 human studies · 52 improved
2 of these 107 human studies gave the ingredient by drip, not by mouth.
107 human studies52 improved31 no effect197,644 people studied
This product pairs calcium with melatonin, and both are taken at doses that matched or came near the doses used in studies. For calcium, large reviews of pregnant women found it lowered the risk of pregnancy-related high blood pressure and preeclampsia [1][2]. However, a large trial in healthy first-time pregnant women taking 2 grams a day found no benefit [3]. In people with normal blood pressure, calcium lowered readings by only about 1 to 1.5 points, with bigger effects in people under 35 [4][5]. In adults with high blood pressure, the top number fell by about 2.5 points, but the trials were poor quality [6]. For melatonin, pooled trials found it lowered blood pressure by about 3 points [7], including in people with metabolic disorders [8]. Slow-release melatonin lowered nighttime readings but fast-release did not [9]. Two milligrams of slow-release melatonin at bedtime lowered nighttime pressure in treated patients with high blood pressure [10]. A pooled look at high blood pressure trials found a drop that was not statistically reliable [11]. The 600 milligram blend does not list its amounts, so its contents cannot be judged. Animal and cell studies are never counted.
See all 107 studies →Hide the studies
- Across 130 trials with about 112,900 pregnant women, calcium supplements lowered the risk of preeclampsia or pregnancy-related high blood pressure (odds ratio 0.71) compared with controls.Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled …
- In 50 trials with about 57,800 pregnant women, calcium cut the risk of gestational high blood pressure versus placebo (odds ratio 0.55), and calcium plus a med cut it further (odds ratio 0.12).The preventive effects of different interventions on gestational hypertension: incidence and network meta-analysis.
- In 18 trials with 3,140 people with normal blood pressure, calcium supplements lowered systolic blood pressure by about 1.4 mmHg and diastolic by about 1.5 mmHg versus placebo or control, with larger effects in people under 35.Calcium supplementation for prevention of primary hypertension.
- In 18 trials with 3,140 people with normal blood pressure, calcium supplements lowered systolic blood pressure by about 1.4 mmHg and diastolic by about 1.5 mmHg versus placebo or control, with larger effects in people under 35.Calcium supplementation for prevention of primary hypertension.
- In 16 trials with 3,048 people with normal blood pressure, calcium supplements lowered systolic blood pressure by about 1.4 mmHg and diastolic by about 1 mmHg, with the largest effect at more than 1,500 mg a day.Calcium supplementation for prevention of primary hypertension.
- Across nine trials of 631 heart attack patients, melatonin did not significantly improve heart function or infarct size overall, though early injected doses helped and it lowered inflammation and oxidation markers; blood pressure was not assessed.Evaluation of Melatonin Therapy in Patients with Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-An…
- In 13 trials with 485 adults with high blood pressure followed 8 to 15 weeks, calcium lowered systolic pressure by 2.5 mmHg but not diastolic pressure, and the authors judged the evidence weak because of poor trial quality.Calcium supplementation for the management of primary hypertension in adults.
- In six trials of spine surgery patients (227 given 3-10 mg melatonin, 125 given placebo), melatonin was linked to better blood-pressure-related outcomes versus placebo in most studies over up to 24 hours.Evaluating the utility of melatonin in spine surgery: a systematic review and meta-analysis of randomized clinical trial…
- In five placebo-controlled trials of 248 patients on antipsychotics, melatonin or ramelteon lowered systolic blood pressure by about 3.3 mmHg more than placebo.Melatonin and melatonin-agonists for metabolic syndrome components in patients treated with antipsychotics: A systematic…
- In seven trials of 221 people, melatonin overall did not lower nighttime blood pressure, but controlled-release melatonin cut systolic by 6.1 and diastolic by 3.5 mmHg while fast-release had no effect.Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials.
- In four trials of 118 patients on antipsychotics, melatonin up to 5 mg daily for up to 12 weeks lowered diastolic blood pressure by about 4.4 mmHg versus placebo, but the systolic change was not clearly significant.Melatonin for Atypical Antipsychotic-Induced Metabolic Adverse Effects: A Meta-Analysis of Randomized Controlled Trials.
- Across eight randomized trials in people with metabolic disorders, melatonin supplements lowered both the top (systolic) and bottom (diastolic) blood pressure numbers compared with control groups, though results varied a lot between studies.The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and…
- Pooling five randomized trials, melatonin lowered systolic blood pressure by 3.4 mmHg and diastolic by 3.3 mmHg compared with control.Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled T…
- In four trials in people with high blood pressure, controlled-release melatonin lowered asleep systolic pressure by about 3.6 mmHg, but the result was not statistically significant, and evidence quality was low to very low.Controlled-release oral melatonin supplementation for hypertension and nocturnal hypertension: A systematic review and m…
- A review of nine studies on preeclampsia (one human trial, eight animal studies) found that melatonin lowered systolic blood pressure by about 18 mmHg in six animal studies; the only human trial (30 mg a day) lengthened time to delivery by 6 days but proteinuria increased, so evidence in people is too limited to recommend it.Melatonin in Preeclampsia: a Systematic Review of its Role in Pathogenesis and Therapeutic Potential.
- In four trials of 138 patients on antipsychotics, melatonin lowered blood pressure in people with bipolar disorder but not clearly in people with schizophrenia.The role of melatonin and melatonin agonists in counteracting antipsychotic-induced metabolic side effects: a systematic…
- A review of calcium-rich mineral water noted that some studies showed lower blood pressure, but gave no numbers and said more research is needed.Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review.
- A review of 34 studies in pregnant women found calcium supplements were linked to less and milder gestational high blood pressure and preeclampsia, with the strongest benefit at 1.5 to 2 grams a day.Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies.
- A review of 50 controlled studies found melatonin side effects were generally minor, though a few studies noted changes in blood pressure and heart rate that depended on dose, timing and use of meds.Adverse events associated with oral administration of melatonin: A critical systematic review of clinical evidence.
- A review of nine studies of nutrition after long-lasting mild head injury, covering six approaches including melatonin, found they were safe and may improve several outcomes such as systolic blood pressure, but the abstract gives no melatonin-specific blood pressure result, dose, or number of people.A Potential Role Exists for Nutritional Interventions in the Chronic Phase of Mild Traumatic Brain Injury, Concussion an…
- In 4589 healthy first-time pregnant women, 2 g of calcium daily from mid-pregnancy to delivery did not reduce preeclampsia (6.9% vs 7.3% with placebo) or change average blood pressure.Trial of calcium to prevent preeclampsia.
- In 1194 first-time pregnant women, 2 g of calcium daily from week 20 of pregnancy lowered high blood pressure disorders of pregnancy (9.8% vs 14.8% with placebo).Calcium supplementation to prevent hypertensive disorders of pregnancy.
- In 698 healthy adults with high-normal blood pressure, 1 g of calcium daily for 6 months did not significantly change blood pressure compared with placebo, though white women might have benefited.Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure. Resu…
- In 524 healthy first-time pregnant women, 2 g of calcium daily lowered preeclampsia (4.0% vs 12.0% with placebo) and blood pressure at the end of the study, though this paper was later retracted.Calcium supplementation for the prevention of pre-eclampsia.
- In 350 patients having skin cancer surgery, a single dose of melatonin did not reduce anxiety versus placebo, and none of the drugs tested significantly changed vital signs such as blood pressure.Efficacy and Safety of Anxiolytics in Mohs Micrographic Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial.
- In 260 pregnant teenagers with low calcium intake, 2000 mg of calcium daily from 20 weeks of pregnancy until delivery cut preeclampsia to 3.2% versus 15.5% on placebo and lowered systolic blood pressure by 9.1 and diastolic by 6.0 mmHg.Calcium supplementation and the risk of preeclampsia in Ecuadorian pregnant teenagers.
- In 201 first-time pregnant women, 2 g of calcium daily from 20 weeks until delivery lowered pregnancy-induced high blood pressure to 8.24% versus 29.03% on placebo.Calcium supplementation and prevention of pregnancy induced hypertension.
- In 146 heart attack patients given melatonin by vein and into the heart artery during angioplasty, heart damage size did not differ from placebo and heart pumping function and volumes recovered less well than with placebo.Effect of intravenous and intracoronary melatonin as an adjunct to primary percutaneous coronary intervention for acute …
- In 125 adults with mild untreated high blood pressure, 6 months of calcium (1000 mg daily), alone or combined with potassium or magnesium, did not lower blood pressure more than placebo.Combinations of potassium, calcium, and magnesium supplements in hypertension.
- In 120 cataract surgery patients aged 50 to 80, a single 3 mg melatonin dose under the tongue before surgery lowered anxiety, pain and eye pressure versus placebo; blood pressure was measured but no difference was reported.The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthes…
- In 101 fifth-grade children, 600 mg of calcium daily for 12 weeks lowered systolic blood pressure by 1.8 mm Hg versus placebo, though this was not statistically significant overall; the effect was larger in children with low calcium intake and diastolic pressure barely changed.Effect of calcium supplementation on blood pressure in children.
- In 100 patients starting second-generation antipsychotics, taking 3 mg of slow-release melatonin at night lowered systolic blood pressure compared with placebo.Effect of melatonin in reducing second-generation antipsychotic metabolic effects: A double blind controlled clinical tr…
- In 97 adults aged 63 to 91, taking 1.5 mg of melatonin each evening for two weeks lowered systolic and diastolic blood pressure compared with placebo, with the largest drop in the early morning hours.Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms.
- In 92 people with heart failure, 10 mg melatonin daily for 24 weeks improved blood vessel flexibility compared with placebo, but did not change blood pressure, and the benefit was not seen in people with diabetes.Effect of melatonin supplementation on endothelial function in heart failure with reduced ejection fraction: A randomize…
- In 84 kidney transplant recipients given 6 mg of melatonin daily for three months, blood pressure did not differ from placebo, although triglycerides and HbA1c improved.Effect of Melatonin Supplementation on Glycemic and Lipid Profiles in Kidney Transplant Recipients: A Clinical Trial.
- In 82 hemodialysis patients, 3 mg of melatonin taken at night for six weeks did not change blood pressure compared with placebo, although sleep quality improved.The effect of oral melatonin on the quality of life, sleep and blood pressure of hemodialysis patients: a randomized cli…
- In 80 newborns with high lung blood pressure, adding oral melatonin to standard care improved the heart's pumping function and was linked to earlier weaning from breathing support and lower heart stress markers than standard care alone.Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension.
- In 78 people with postural tachycardia syndrome, a single 3 mg dose of melatonin lowered standing heart rate more than placebo but did not change systolic blood pressure, seated or standing.Melatonin reduces tachycardia in postural tachycardia syndrome: a randomized, crossover trial.
- In 78 patients having wisdom tooth surgery, a single 6 mg oral dose of melatonin improved pulse and blood pressure readings compared with no intervention.Comparison of melatonin and music therapy as a preoperative anxiolytic for patients undergoing impacted mandibular third…
- In a randomized, placebo-controlled crossover trial of 70 adults (43 with hypertension, 27 without), 1000 mg of elemental calcium daily for 8 weeks did not significantly change blood lipids in the hypertensive group, and the abstract reports no blood pressure result; normotensive adults with mildly high cholesterol had a small drop in total cholesterol.Plasma lipids and hypertension: response to calcium supplementation.
- Taking 6 mg of melatonin by mouth before surgery blunted the rise in heart rate and blood pressure caused by tube insertion under anesthesia in 64 patients compared with placebo.Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, contro…
- In 60 patients with coronary artery disease and abnormal night-time blood pressure, 5 mg of melatonin for 90 days normalized the blood pressure pattern in 35% versus 15% on placebo (not a significant difference), lowering night blood pressure but also raising daytime blood pressure.Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability.
- In 60 cataract surgery patients, 3 mg of sublingual melatonin before surgery reduced anxiety but made no significant difference to blood pressure or heart rate compared with placebo.The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during c…
- In 60 diabetic patients with coronary heart disease, 10 mg of melatonin daily for 12 weeks lowered systolic blood pressure by 4.3 mmHg and diastolic by 2.8 mmHg versus a slight rise or no change with placebo (this paper was later retracted).Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients wit…
- In 60 heart bypass surgery patients, melatonin taken by mouth for 60 days, at 5 mg or 10 mg daily, raised heart pumping strength compared with placebo and lowered markers of inflammation and oxidative stress.Melatonin administered postoperatively lowers oxidative stress and inflammation and significantly recovers heart functio…
- In 57 young adults, 1 g of calcium daily for 22 weeks lowered diastolic blood pressure by 5.6% in women and 9% in men compared with placebo.Reduction of blood pressure with calcium supplementation in young adults.
- In 52 ICU patients with traumatic brain bleeding, melatonin reduced morphine use and ventilator time versus control, and diastolic blood pressure differed between groups, though the abstract does not state the direction of that difference.The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic…
- In 51 adults with mild essential hypertension, 1 gram of daily oral calcium for 8 weeks lowered systolic blood pressure by up to 6 mm Hg and diastolic by up to 3 mm Hg compared with placebo.[Effect of an oral calcium supplement in the treatment of slight-to- moderate essential arterial hypertension].
- In 50 adults with high blood pressure, taking 3 mg of melatonin overnight with moxonidine for 14 days gave a greater blood pressure-lowering effect than moxonidine alone and normalized the daily blood pressure and heart rate rhythm.[Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial …
- In 50 adults with type 2 diabetes, melatonin supplements taken daily for eight weeks lowered systolic and mean arterial blood pressure more than placebo.Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 di…
- In 49 women with chronic high blood pressure, taking 2 g of calcium plus low-dose a med from mid-pregnancy until delivery did not significantly reduce preeclampsia compared with placebo.Read the study on PubMed (24728212) →
- In 47 hypertensive patients well controlled on nifedipine, 5 mg of evening melatonin for 4 weeks raised 24-hour systolic blood pressure by 6.5 mmHg and diastolic by 4.9 mmHg compared with placebo.Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study.
- In 45 adults with fatty liver disease, taking 6 mg of melatonin at bedtime for 12 weeks lowered systolic and diastolic blood pressure more than placebo, along with weight, liver enzymes and inflammation markers.The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clini…
- In 44 people taking antipsychotic drugs, 5 mg of melatonin for 8 weeks produced a larger drop in diastolic blood pressure than placebo (5.1 vs 1.1 mmHg) and less weight gain.Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-co…
- In 43 patients with stable angina and high blood pressure, adding melatonin to standard treatment produced a larger drop in daily and nighttime blood pressure than standard treatment alone.[Melatonin in combined therapy of patients with stable angina and arterial hypertension].
- In 41 healthy postmenopausal women, 10 mg of melatonin daily for three months did not significantly change blood pressure or arterial stiffness compared with placebo, and it was well tolerated.Effects of melatonin on blood pressure, arterial stiffness and quality of life in postmenopausal women: A randomized con…
- In 40 postmenopausal women, a single 1 g calcium citrate dose made the systolic blood pressure drop after breakfast smaller than placebo, by 6 to 9 points over 4 to 6 hours.Acute effects of calcium supplements on blood pressure: randomised, crossover trial in postmenopausal women.
- In 40 menopausal women, adding melatonin to myo-inositol for 6 months was reported to affect insulin and thyroid measures, and the abstract gives no blood pressure result.Myo-inositol and melatonin in the menopausal transition.
- In 40 African American adults with high blood pressure, a 24 mg sustained-release melatonin dose taken at night for 4 weeks did not lower nighttime or daytime blood pressure compared with placebo.Nighttime administration of high-dose, sustained-release melatonin does not decrease nocturnal blood pressure in African…
- In 38 treated hypertensive patients with high night-time blood pressure, 2 mg of controlled-release melatonin taken before bed for four weeks lowered night-time systolic and diastolic blood pressure more than placebo.Melatonin reduces night blood pressure in patients with nocturnal hypertension.
- In 38 adolescents with bipolar disorder taking olanzapine and lithium, adding melatonin for 12 weeks slowed the rise in systolic blood pressure and cholesterol compared with placebo, though diastolic blood pressure showed no clear pattern.Melatonin decreases olanzapine induced metabolic side-effects in adolescents with bipolar disorder: a randomized double-…
- Taking 2 mg of melatonin nightly for six weeks did not beat placebo for blood pressure or arterial stiffness in 38 women aged 55 and older with insomnia, although systolic pressure fell within the melatonin group.Melatonin Supplementation for Six Weeks Had No Effect on Arterial Stiffness and Mitochondrial DNA in Women Aged 55 Years…
- In 34 patients having heart bypass surgery, 60 mg of melatonin daily starting 5 days before surgery lowered diastolic blood pressure and inflammation markers compared with placebo.Melatonin ameliorates inflammation and improves outcomes of ischemia/reperfusion injury in patients undergoing coronary …
- In 32 surgical patients, melatonin given before anesthesia did not lower blood pressure as much as clonidine did, and clonidine caused the bigger drop in heart rate and blood pressure.Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target…
- In 31 postmenopausal women, a single 1 mg dose of melatonin lowered blood pressure within 90 minutes in the 13 women on hormone replacement therapy but had no effect in the 18 untreated women.Different circulatory response to melatonin in postmenopausal women without and with hormone replacement therapy.
- In 30 high-risk pregnant women, 2 grams of daily calcium from 28 to 32 weeks of pregnancy reduced pre-eclampsia cases from 7 to 1 compared with placebo, but did not meaningfully change pregnancy-related high blood pressure, which was only delayed by about 3 weeks.Supplementary calcium in prevention of pre-eclampsia.
- In 26 healthy men, a single 2 mg dose of melatonin lowered supine blood pressure and increased heart rate variability within 60 minutes compared with placebo.Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men.
- In 24 young men, single melatonin doses of 0.5 mg or 5 mg changed hormone release during saline infusion and exercise, and the study did not report a blood pressure benefit.The effect of exogenous melatonin on stimulated neurohypophysial hormone release in man.
- In a small randomized trial of 24 rotating night shift workers, light exercise before each night shift for 12 weeks did not change daily melatonin rhythms, blood sugar control, or 24-hour blood pressure.Timed physical exercise does not influence circadian rhythms and glucose tolerance in rotating night shift workers: The …
- In 24 night shift workers, 2 mg of sustained-release melatonin at bedtime for 12 weeks did not significantly change daytime-night blood pressure patterns compared with placebo.Effect of oral melatonin treatment on insulin resistance and diurnal blood pressure variability in night shift workers. …
- In 23 postmenopausal women, a single 1 mg dose of melatonin lowered systolic and diastolic blood pressure by 8 and 4 mmHg only in those using hormone replacement therapy, with no effect in women not using it.Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replaceme…
- In 22 people with stage II high blood pressure, adding 3 mg of melatonin at night to meds for 2 weeks lowered systolic, diastolic and mean blood pressure more than the drug alone, though the daily blood pressure rhythm did not return to normal.[Capozide-50 alone and in combination with melatonin in therapy of hypertension].
- Taking 10 mg of melatonin daily for 10 days on a high-salt diet lowered nighttime blood pressure in 22 healthy adults compared with placebo, but did not change 24-hour average blood pressure or blood pressure response to stress tests.Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive…
- In 20 adults with untreated mild to moderate high blood pressure, 2 grams of daily calcium for 12 weeks did not lower blood pressure compared with placebo.Effect of oral calcium supplementation on blood pressure in patients with previously untreated hypertension: a randomise…
- In 20 healthy young men, a single day of four 10 mg melatonin doses lowered systolic blood pressure only in carriers of one gene variant, while overall insulin sensitivity was reduced.Acute metabolic effects of melatonin-A randomized crossover study in healthy young men.
- In an 18-person double-blind crossover trial, 1600 mg of elemental calcium daily for one month did not lower blood pressure in adults with mild to moderate untreated hypertension compared with placebo.Does oral calcium supplementation lower high blood pressure? A double blind study.
- Taking a 3 mg slow-release melatonin pill at bedtime for three weeks lowered nighttime blood pressure compared with placebo in 18 women, with normal or treated high blood pressure, in a crossover trial.Prolonged melatonin administration decreases nocturnal blood pressure in women.
- In 17 young healthy women, a single 1 mg daytime dose of melatonin lowered systolic and diastolic blood pressure compared with placebo and reduced the stress hormone norepinephrine on standing.Influences of melatonin administration on the circulation of women.
- In 16 healthy young adults, a single 5 mg melatonin capsule lowered systolic blood pressure by about 6 mmHg at 150 minutes compared with placebo, with no change in diastolic pressure.The effects of bright light and nighttime melatonin administration on cardiac activity.
- In 16 men with untreated essential hypertension, 2.5 mg of melatonin taken at bedtime for 3 weeks lowered blood pressure during sleep by about 6 and 4 mm Hg compared with placebo, while a single dose had no effect.Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.
- In 15 adults with type 2 diabetes who completed the study, 10 mg of melatonin taken at bedtime for three months did not significantly lower blood pressure compared with placebo, though nighttime readings trended lower.Effects of bedtime melatonin treatment on blood pressure and arterial stiffness: a three-month, randomized, placebo-cont…
- In 12 healthy adults, 3 mg of melatonin reduced the nerve activity response to head-down rotation compared with placebo, suggesting poorer tolerance of standing, and the abstract gives no blood pressure change.Melatonin attenuates the vestibulosympathetic but not vestibulocollic reflexes in humans: selective impairment of the ut…
- A single 3 mg dose of melatonin blunted the blood pressure and heart rate rise caused by mental stress compared with placebo in 12 healthy adults.Melatonin attenuates the skin sympathetic nerve response to mental stress.
- In 12 young women on contraceptive pills, 1 mg of melatonin lowered systolic and diastolic blood pressure when lying down within 90 minutes compared with placebo.Potentially beneficial cardiovascular effects of melatonin administration in women.
- In 11 adolescents with type 1 diabetes and normal blood pressure, 5 mg of melatonin taken for 1 week increased the overnight drop in diastolic blood pressure compared with placebo, while healthy controls showed no drug effect.Blood pressure response to melatonin in type 1 diabetes.
- In 10 healthy young men, a single 10 mcg melatonin infusion did not change brain blood flow compared with placebo, though it increased blood flow in the skin.No influence of melatonin on cerebral blood flow in humans.
- In healthy men, a single 1 mg oral dose of melatonin lowered blood pressure within 90 minutes compared with placebo.Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men.
- In 404 pregnant women with gestational hypertension or pre-eclampsia in India, adding melatonin to standard care was linked to fewer cases of severe pre-eclampsia needing cesarean delivery and fewer intrauterine deaths than standard care alone.Melatonin as an adjuvant therapy in gestational hypertension and pre-eclampsia: A randomized controlled trial.
- In 400 pregnant women, 375 mg of calcium plus 1,200 IU of vitamin D daily from 20-24 weeks lowered blood pressure in women without toxaemia, but toxaemia rates (6% versus 9%) did not differ significantly.Effect of calcium and vitamin D supplementation on toxaemia of pregnancy.
- In 50 free-living volunteers, 1,150 mg of daily dietary calcium from dairy for 6 months lowered systolic blood pressure compared with an orange juice control, though the result was not strongly significant and diastolic blood pressure did not change.Dietary calcium. A method of lowering blood pressure.
- In 30 adults with metabolic syndrome who had not responded to three months of lifestyle changes, 5 mg of melatonin taken nightly for two months lowered systolic blood pressure from about 133 to 121 mmHg and diastolic pressure from about 82 to 75 mmHg, compared with their own baseline.Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metaboli…
- In 16 people lying down at night, melatonin raised to pharmacological levels lowered systolic blood pressure by about 6 mmHg without changing heart rate or heart nerve activity.Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night.
- A single 5 mg dose of melatonin at bedtime lowered systolic blood pressure after insulin-induced low blood sugar compared with placebo in 14 healthy young men.Melatonin does not inhibit hypothalamic-pituitary-adrenal activity in waking young men.
- In 11 adults, a single 3 mg melatonin tablet blunted the nerve activity surge during standing stress, but arterial blood pressure responses did not change compared with placebo.Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans.
- In 39 people with coronary artery disease and abnormal overnight blood pressure patterns, 5 mg melatonin before sleep for 30 days normalized the pattern in about 31 percent, while 23 percent had an unfavorable change.[The influence of melatonin supplementation on circadian pattern of blood pressure in patients with coronary artery dise…
- In 23 people with high blood pressure taking 1 mg of melatonin daily for one year, arterial stiffness improved significantly compared with the untreated control group, though endothelial function change was not significant.Essential Hypertension and Oxidative Stress: Novel Future Perspectives.
- In 11 people who had their pineal gland removed, 0.3 mg of melatonin daily for six months lowered diastolic and morning blood pressure but raised pulse pressure in an open-label study without a control group.Human Pinealectomy Syndrome and the Impact of Melatonin Replacement Therapy: 1-Cardiovascular Function.
- In 1098 older adults, dietary calcium was linked to better bone density, and this study did not report a calcium link to blood pressure.Dietary intake, blood pressure and osteoporosis.
- In a random sample of 976 people in Cape Peninsula, hypertensive adults had lower calcium intakes than normotensive adults, but this cross-sectional survey did not test calcium supplementation and so cannot show that calcium lowers blood pressure.Hypertension in the coloured population of the Cape Peninsula.
- In 662 children with high cholesterol, higher dietary calcium intake was linked to lower blood pressure over 3 years, but this observational study cannot prove cause.Nutrient intake and blood pressure in the Dietary Intervention Study in Children.
- In a nested case-control study of 209 women who later had a heart attack and 209 matched controls, lower overnight melatonin levels in morning urine were linked to a higher risk of heart attack, especially in women with higher body mass index.A nested case-control study of the association between melatonin secretion and incident myocardial infarction.
- In 226 patients with heart disease, 3 mg of melatonin taken before bed as part of their treatment improved sleep and normalized daily blood pressure and heart rate patterns, in an uncontrolled study.[Sleep disorders and circadian rhythms in diseases of the cardiovascular system].
- A descriptive survey of 167 free-living elderly Greeks found high blood pressure to be common and calcium intake above half of the US recommended allowance, but it did not test any calcium supplement or report a blood pressure effect of calcium.Nutrition status of the elderly in Anogia, Crete, Greece.
- In 81 older adults taking melatonin at high doses (40 to 200 mg daily, mean about 73 mg) for sleep problems, high blood pressure, heart disease and diabetes became less common over time compared with an untreated group.Rethinking Melatonin Dosing: Safety and Efficacy at Higher-than-Usual Levels in Aged Patients with Sleep Disturbances an…
- In 100 older adults with stage II high blood pressure, lower melatonin production was linked to problems with blood sugar and blood fats, and taking melatonin with meds normalized these metabolic measures; the abstract does not report blood pressure results.[Metabolic disorders in elderly patients with hypertension and their correction with melatonin].
- In 20 women with early-onset preeclampsia, melatonin was safe and delayed delivery by about 6 days, and fewer women needed increased meds compared with recent historical controls.Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia.
- A review of 19 calcium supplement trials found most showed no significant blood pressure effect, and pooled estimates suggested only a small reduction of about 1.8 mmHg in systolic pressure, so the authors called the evidence suggestive but not conclusive.Calcium and blood pressure. An epidemiologic perspective.
Review Totals and Summary
Members Only54 reviews · 88% positive
54 reviews · Google Shopping 54
88% positive0% neutral12% negative
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
The product's main ingredient is listed as calcium, but nearly all of the panel's comments are about melatonin, so this summary leans on what they said about both. Only a few of them spoke about calcium: two recommend it for bone health, one of whom suggests 1,000 to 1,200 milligrams a day from carbonate or citrate, while another warns against calcium supplements, calls carbonate the worst source, and prefers food such as dairy, sardines or leafy greens. On melatonin, most of the panel uses or recommends it, mainly for sleep onset and jet lag, and they favor the lowest effective dose, from 0.3 to 3 milligrams, often taken only occasionally or for a few nights. Several also warn against long-term or nightly use, citing heart risk, less REM sleep in children, and the high doses in commercial products, and some note it often does not fix waking in the night. They suggest pairing it with good sleep habits and dim evening light, with one saying to take it about three hours before bed.
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Dr. Eric Berg · Calcium · neutral
- States that one can of sardines contains 382 mg of calcium.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Warns against calcium carbonate, calling it limestone and the worst source of calcium, stating it takes 12 steps to be converted in the body and is like eating rocks.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
- Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
- Dr. Eric Berg warns that taking melatonin stops a good night's sleep.
- States that melatonin, the hormone that helps you fall asleep, is influenced by eating habits.
- Mentions that melatonin, the hormone that helps you fall asleep, is influenced by eating habits.
- Explains that melatonin is a hormone activated by darkness that helps with sleep and also helps the pancreas release less insulin.
Siim Land · Melatonin · recommends
- Recommends using the lowest effective dose of melatonin, noting that while the peak was at 4 mg in an analysis, a smaller dose might be sufficient for some individuals.
- Recommends taking Melatonin 3 hours before bed, citing a meta-analysis that found this timing superior to 30 minutes before bed.
- States that Melatonin can be a useful addition for some people for sleep.
- States that Melatonin connects biology to light, signals biological night, and can be suppressed by bright evening light.
- Notes that melatonin activates AMPK and upregulates autophagy, and advises protecting melatonin production before bed by avoiding eating a lot of food.
- Has experimented with melatonin supplementation, finding that a smaller dose like 0.3 mg or 1 mg works better for him, and notes that a meta-analysis found optimal timing to be 3 hours before bedtime.
- Recommends Melatonin for sleep and circadian rhythm, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Melatonin as one of 15 supplements backed by human studies.
- Lists dairy and sardines as sources of Calcium.
- Notes that melatonin supplementation has been seen to reverse age-related decline in immune function in rats and reduce inflammatory markers and support immune function in humans, but its effect on thymic regeneration in humans hasn't been studied.
- Thinks melatonin has some of the strongest evidence and is worth considering.
- Notes that Boron reduces calcium/magnesium loss.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
Dr. Mark Hyman · Melatonin · neutral
- Explains that around 3 or 4 a.m., melatonin levels drop naturally, and if someone consistently wakes up then, it's likely they are running out of melatonin because they stayed up too late for their body's natural rhythm.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- Treats sleep as a non-negotiable part of their health routine, just like diet and exercise, and uses melatonin for recovery.
- States that green leafy vegetables are great sources of calcium.
- Recommends low-dose melatonin (even half a milligram) for short-term use to help reset circadian rhythm, especially when traveling or experiencing schedule disruption, but not as a long-term solution.
- Mentions melatonin as something that actually helps with sleep.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
- Lists calcium as another important nutrient that people can be tested for and measured.
- States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
- Explains that if serotonin gets to the brain, the pineal gland turns it into melatonin so one can sleep.
- Recommends melatonin, at a dose of 3 to 60 milligrams a day, for reducing reflux symptoms like heartburn or stomach pain, noting it can be as effective as a med without the side effects of meds.
- Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
Dave Asprey · Melatonin · neutral
- Notes that rodent research suggests melatonin supports drainage machinery, but it is a timing signal and not the pump itself.
- Host Dave Asprey discusses a study linking long-term melatonin use to nearly double the heart failure risk and all-cause mortality, and advises against relying on it every night.
- Mentions taking melatonin to go to sleep at night.
- Warns that melatonin may help kids fall asleep, but a study found less REM sleep among children taking it, which supports memory, learning, and emotional processing.
- Mentions that people have probably tried melatonin to sleep better.
- Recommends melatonin to help set the body's sleep timing and notes that researchers found it increased a marker linked to DNA repair by 80% during sleep.
- States that melatonin only goes so far and doesn't tell the brain to stop spinning.
- Warns listeners to ramp up melatonin slowly if they choose to take it, as a meaningful number of people experience arrhythmia from high doses, and he personally ended up in the hospital after taking 40 milligrams due to skipped heartbeats.
- Notes that during a dark retreat, the brain makes high levels of melatonin.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Warns that taking melatonin will not help if the brain is electrically awake, as it will only lead to feeling tired but wired.
Thomas DeLauer · Melatonin · uses
- Has stopped 'tough-guying' through situations where he needs sleep and now occasionally uses 1 or 2 milligrams of melatonin for jet lag or when he needs to ensure good sleep, such as when his family is sick. He finds that using it sparingly makes it effective.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Warns that melatonin and other substances that bind to a med or GABA A receptors can sedate you into sleep and make you feel groggy upon waking, unlike glycine.
- Mentions that Dr. D'Agostino discusses interesting use cases where high dosages of melatonin have powerful antioxidant effects, calling it a remarkable compound and antioxidant in the body.
- States that people try melatonin for sleep, but it often doesn't solve the problem of waking up in the middle of the night.
- Warns against supplemental melatonin, calling it a blunt tool that overrides circadian signals, noting that over-the-counter doses are often ridiculously high and can lead to grogginess or dependence.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Warns that melatonin, like other common sleep supplements, does not directly address the physiological issues of body temperature and brain restlessness, instead only nudging a hormone or sedating the user.
- States that melatonin can only rise meaningfully when cortisol is falling, and that artificial light after sunset can rob the body of melatonin during the night by keeping evening cortisol elevated.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Advises against taking melatonin for sleep for most people, especially in high doses like 10 mg, which he considers a dramatic overdose. He uses it only for travel or sleep deprivation to reset circadian rhythm, taking 0.5 to 1 mg, but warns against taking it every single night.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
Andrew Huberman · Melatonin · neutral
- Discusses Melatonin.
- Notes that some fertility experts recommend low-dose melatonin at night, presumably to improve sleep, for fertility, while others do not.
- Mentions that studies have shown improvements in sleep issues with the use of melatonin, particularly for those experiencing sleep problems after a traumatic brain injury.
- Advises caution for melatonin supplementation.
- Warns that taking melatonin chronically over time, especially for kids, can be problematic due to supra-physiological dosages in most commercial products and its interaction with other hormone systems.
- Mentions melatonin in the context of sleep.
- Recommends slow doses of melatonin supplementation, 1 to 3 mg 30 minutes before bed, for improving odds of getting pregnant and egg quality, especially for those with increased chronic inflammation or poor egg quality.
- Raises a question about melatonin supplements.
- Is not a big fan of melatonin supplementation, stating that the levels in most supplements are far too high to be considered physiological and can have effects not just related to sleep.
- Warns that melatonin supplementation is not particularly helpful as a sleep aid for healthy adults, with studies showing minimal increases in sleep time and efficiency, and typical doses being far higher than what the body naturally produces.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Adequate intake of calcium is vital for bone health.
Ben Greenfield · Melatonin · warns
- Warns that high-dose melatonin seems to make one more photosensitive, so it's important to block blue light and harsh light when taking it to avoid theoretical risks.
- Continues to use melatonin for jet lag, taking a high dose for the first one to two nights when traveling across more than three time zones, despite a study linking long-term use to heart failure risk.
- Discusses how he uses melatonin as a "sledgehammer" when traveling, while also addressing concerns about a study linking melatonin to increased heart failure risk, suggesting the study may be mixing up cause and effect.
- Discusses melatonin in the context of common sleep OTCs, noting that while it works, the Harmonic device achieves similar results non-pharmacologically without downregulating sleep receptors.
- Mentions Melatonin as a supplement people cycle through when still sleeping poorly, suggesting it might not be addressing the true sleep problem.
- Warns that no amount of melatonin will fix a nervous system that isn't downshifting properly.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Notes that a study showed blue light blockers preserve melatonin, which has benefits for cancer prevention, sleep, and as an antioxidant, despite the study's focus on subjective sleepiness.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Discusses how to interpret recent melatonin headlines, where the data falls short, and how he approaches melatonin use in real-world scenarios like travel.
- Offers perspective on the melatonin-heart health headlines, advising not to panic if it is used sensibly.
- Discusses a study suggesting that long-term use of high-dose melatonin (3 to 6 milligrams or higher) by individuals with pre-existing health issues and chronic insomnia may have potential impacts on heart health, including heart failure and all-cause mortality.
Dr. Rhonda Patrick · Melatonin · recommends
- Recommends taking 3 milligrams of melatonin at night, as it has been shown to improve IVF outcomes by acting as an antioxidant within the follicular environment.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Explains that as melatonin rises before bedtime, it signals organs to shift into recovery mode, which may make insulin secretion less efficient late at night.
- Warns to be careful of melatonin supplements.
- Rhonda takes 0.5 mg of Melatonin before bed for sleep.
- Is currently taking melatonin because she is jet lagged after returning from China.
- Notes additional gaps in calcium.
- A preliminary (not peer-reviewed) conference abstract reported that adults with insomnia with ≥1 year of documented melatonin use had a 90% higher 5-year rate of heart failure and 3.5x more hospitalizations than adults without.
- Expresses surprise at the range of effects attributed to melatonin.
- States that melatonin supplements do not shut down the body's own melatonin production and that human data shows no evidence that commonly used doses suppress endogenous melatonin or cause tolerance.
- Recommends low-dose melatonin as a better option for a sleep-promoting supplement.
- Introduces the topic of melatonin supplements, implying there is a 'shocking truth' about them.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
Bryan Johnson · Melatonin · uses
- Used 3 mg of melatonin before bed as part of their jet lag recovery.
- Uses 3 mg of melatonin before bed as part of a jet lag recovery protocol.
- Is bullish on pharmacological interventions for jet lag, including melatonin and extended-release melatonin, or a combination of instant and extended release.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Takes a melatonin supplement before bed, as his team found the evidence relevant for him.
- Takes melatonin right before bed as part of his nightly routine.
- Recommends melatonin at 1 to 3 mg nightly to help improve sleep quality for women during the luteal phase.
- Takes 300 mcg of melatonin each night for sleep.
- Uses Melatonin at 0.1% in his custom topical hair formulation.
- Recommends taking extended-release melatonin before bed for at least the first three nights to promote sleep on a new schedule and shorten jet lag.
- Recommends calcium at 1,200 mg daily for women during the follicular phase, depending on dietary intake.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
Peter Attia · Melatonin · neutral
- Peter discusses Melatonin for circadian timing, explaining how timing signals differ from sedatives in the treatment of sleep disorders.
- States that melatonin can aid with sleep initiation, especially as melatonin levels go down with age, but it's only a signal to initiate sleep and won't necessarily keep you asleep. He recommends the lowest dose, around 300 micrograms.
- Recommends melatonin for sleep initiation, especially as melatonin levels decrease with age, but stresses the importance of first optimizing sleep hygiene and using the lowest effective dose, around 300 micrograms, and not exceeding one milligram.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Suggests melatonin can be a viable tool for sleep initiation, especially as melatonin levels decline with age, but only after optimizing sleep hygiene and at the lowest effective dose, such as 300 micrograms.
- States that the data for melatonin are pretty weak except in certain cases and that taking melatonin can mess people up by forcing them to sleep when their body isn't ready.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Warns that some sleep supplements may contain far more melatonin than the label indicates, providing another reason to be conservative in their use.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Warns that one must be limited in how much and how often melatonin is used for sleep.
- Recommends getting about a gram of calcium a day from organic bone meal, which provides calcium hydroxyapatite, the form humans are meant to consume.
- Explains that melatonin is secreted by the pineal gland in the absence of blue light, signaling to the brain that it's dark and removing the brakes of staying awake.
RAL Summary
Members OnlyTier 3 for Blood Pressure
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Nervous system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: No major side effects reported in the studies given; one trial found melatonin raised blood pressure in people taking the meds nifedipine.
Supplement Facts
Calcium 288 mg · Exclusive Blend 600 mg · Melatonin 2 mg
Supplement Facts
Serving Size 1-2 Tablet(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Calcium | 288 mg | |
| Exclusive Blend | 600 mg | † |
| Melatonin | 2 mg | † |
† Daily Value not established.
Other ingredients: Stearic Acid, Maltodextrin, Sodium Carboxymethylcellulose, Silicon Dioxide, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Magnesium Stearate, Dextrin, Dextrose, Soy Lecithin, Sodium Citrate.
Directions: Recommended use: For adults, take 1 or 2 tablets 30 minutes before going to sleep.
Label source: NIH label database · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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