InfoWars M.D Nitric Boost Review
Nitric Boost by Infowars M.D is presented on this Limitless America page as a body-building formula with amino acids, intended for strength and power. The page says the formula helps promote the synthesis and discourages the degradation of Nitric Oxide, which the page describes as beneficial for cardiovascular function. It also lists circulation and muscular performance as areas the formula helps promote. The product is listed under the INFOWARS LIFE brand, with SKU 128-NO2-166. The page shows a price of $54.95 and marks the item as out of stock. No reviews have been posted yet, and the page does not list ingredients, serving size, form, or a UPC barcode.
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Study, Trial or Testing Result Summary
Members Only135 human studies · 66 improved
22 of these 135 human studies gave the ingredient by drip, injection or inhaler, not by mouth.
This product contains small amounts of ingredients studied for blood flow, but every one is far below the doses used in research. L-arginine, at 800 milligrams in total across two forms, is a fraction of the 6 grams that helped in some trials. A single 6 gram dose improved artery widening in people with high blood pressure [1], and a review found a small benefit only in people with poor starting vessel function [2]. The largest trial, at 3 grams daily for 6 months, found no benefit [3]. Citrulline, at 400 milligrams in total, is well below the 3 to 10 grams studied. A review of 8 trials found citrulline improved vessel widening in middle-aged and older adults [4], and 10 grams daily helped women with high blood pressure [5], but 6 grams daily did not help healthy women. Niacin at 30 milligrams is a trace amount, while benefits for artery widening appeared at 1500 to 2000 milligrams or more [6], and some trials at those doses found no effect [7]. Calcium studies, all given into a vein, showed no benefit for blood flow [8]. Beta-alanine has no human studies for this goal. Animal and cell studies are never counted.
See all 135 studies →Hide the studies
- Across 12 short-term placebo-controlled trials with 492 people, oral L-arginine raised blood vessel widening after blood flow was restored by about 2 percentage points, with benefit only in people whose starting level was low (under 7%).Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-media…
- Across seven randomized trials with 441 people, niacin raised artery widening after increased blood flow by about 2 percentage points compared with controls, with larger effects at 2000 mg per day or more.Effect of niacin on endothelial function: a systematic review and meta-analysis of randomized controlled trials.
- Across 8 randomized trials of 176 middle-aged and older adults, L-citrulline improved blood vessel widening (flow-mediated dilation) but not overall arterial stiffness, though it lowered one arm-to-ankle stiffness measure; watermelon had no significant effect.Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-a…
- In 13 trials of people with heart disease, obesity or diabetes, oral L-arginine did not improve blood vessel widening compared with placebo overall, though benefit appeared after removing the most extreme studies.Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabo…
- In 12 trials of 360 postmenopausal women lasting 4 to 8 weeks, citrulline often lowered blood pressure, but results for arterial stiffness were mixed and only 2 of 4 studies showed better blood vessel dilation.Citrulline supplementation in postmenopausal women: a systematic review of vascular, muscular, and metabolic effects.
- A review of 27 studies in people with migraine with aura found no clear blood vessel lining problem; one study showed lower brain artery response to L-arginine in migraine patients.Endothelial function in migraine with aura - a systematic review.
- A review of 25 studies in pregnant women (plus animal studies) found L-arginine lowered blood pressure, reduced pre-eclampsia, and improved blood flow between placenta and fetus in growth-restricted pregnancies compared with controls.L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcomes.
- A review of 19 trials in heart failure found that supplements including L-arginine improved the heart's pumping ability (ejection fraction), but no blood flow result for L-arginine alone was given.Dietary strategies and nutritional supplements in the management of heart failure: a systematic review.
- This review found that evidence for citrulline improving blood vessel dilation and muscle blood flow is scarce and inconsistent, though some studies showed better exercise performance.Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature.
- In 391 adults having a cardiac arrest outside hospital, up to two doses of calcium chloride (5 mmol each) given into a vein or bone did not significantly improve return of a sustained heartbeat compared with saline (19% vs 27%), and the trial was stopped early over concerns about harm.Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospi…
- In 133 people with leg artery disease, 3 g of L-arginine daily for 6 months did not improve blood vessel widening and walking distance improved less than with placebo (11.5% versus 28.3%).L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.
- In 115 pregnant women with preeclampsia, oral citrulline did not prolong pregnancy compared with placebo, and it was linked to higher systolic blood pressure and liver enzymes at delivery.Oral citrulline supplementation in pregnancies with preeclampsia: a multicenter, randomized, double-blind clinical trial…
- In 99 adults with well-controlled HIV and low HDL cholesterol, 1500 mg per day of extended-release niacin for 24 weeks did not significantly change blood vessel dilation or inflammation markers, despite lipid improvements.Extended-Release Niacin Versus Fenofibrate in HIV-Infected Participants With Low High-Density Lipoprotein Cholesterol: E…
- In 87 patients with clogged leg arteries given 6 g of L-arginine daily for 2 months, a blood vessel stress marker (ADMA) fell in those with high cholesterol or mixed blood fats but not high triglycerides alone, and homocysteine did not change significantly.Effect of L‑arginine supplementation on homocysteine and asymmetric dimethylarginine in atherosclerotic lower limb ische…
- In 81 adults aged 40-65 with mildly raised blood pressure, 3 months of L-arginine with B vitamins improved blood vessel function more than placebo and also lowered blood pressure and homocysteine.L-Arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation.
- In 73 adults with prehypertension, 6 weeks of 2 grams of citrulline plus polyphenols did not change average 24-hour blood pressure versus placebo, though systolic pressure fell in women but not men.Sex May Modulate the Effects of Combined Polyphenol Extract and L-citrulline Supplementation on Ambulatory Blood Pressur…
- In 71 a med-treated patients with low HDL cholesterol, 2 g per day of modified-release nicotinic acid for 12 months reduced carotid artery wall area compared with placebo.Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-con…
- In 66 coronary artery disease patients on high-dose meds, 1500 mg per day of extended-release niacin for 3 months improved cholesterol but did not improve blood vessel function versus placebo.Read the study on PubMed (23174368) →
- In 66 healthy adults around age 63, 3000 mg of citrulline daily for 12 weeks improved blood vessel widening only in those with high-normal blood pressure, and lowered a blood marker of oxidative damage overall.Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range o…
- In 63 men after a heart attack, niacin/laropiprant (up to 2000 mg niacin daily) for 12 weeks improved arm artery dilation more than placebo, independent of cholesterol changes.Extended-release niacin/laropiprant improves endothelial function in patients after myocardial infarction.
- In 60 children with thalassemia and lung high blood pressure, 2 months of L-arginine reduced tricuspid jet velocity (a heart ultrasound measure of lung pressure) and raised nitric oxide, similar to a med.Read the study on PubMed (36282078) →
- In 50 children with sickle cell disease and raised heart valve jet speed, L-arginine for 3 months lowered that speed and a heart strain marker and raised nitric oxide compared with the control group.Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Incre…
- In 50 trained cyclists taking citrulline with or without quercetin twice daily for 28 days, nitric oxide metabolites rose over time but no group differed from placebo in nitric oxide or antioxidant markers.Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists.
- In 49 hospitalized patients with raised lung artery pressure, a single 100 mg or 500 mg niacin dose did not significantly change lung artery pressure after 1 hour, though a small non-significant drop appeared at 500 mg.A randomized pilot study on the effect of niacin on pulmonary arterial pressure.
- In 46 adults with long COVID, 1.66 g L-arginine plus vitamin C twice daily for 28 days improved blood vessel widening (14.3% vs 9.4% with placebo), walking distance, grip strength and fatigue.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 44 adults with type 1 diabetes and nerve damage affecting the heart, a 24-month antioxidant combination including nicotinamide did not improve heart blood flow and slightly worsened heart nerve function versus placebo.Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in…
- In 44 healthy postmenopausal women, 4 weeks of 6 grams citrulline alone did not improve blood vessel widening or aortic stiffness, while citrulline plus glutathione did improve vessel widening versus placebo.Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postm…
- In 44 obese adolescents with fatty liver disease, 12 weeks of citrulline with or without interval training did not change arterial stiffness measures, though citrulline with training improved blood fats and fitness.Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents …
- In 33 people with type 2 diabetes (compared with 10 healthy people), 1500 mg a day of extended-release niacin for 3 months improved the ability of HDL cholesterol to boost nitric oxide, lower oxidative stress and support blood vessel repair versus placebo.Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus bu…
- In 42 older adults with mild memory impairment, nicotinamide riboside (a niacin-related form) for 12 weeks doubled blood NAD but did not improve total brain blood flow or blood pressure compared with placebo, though regional blood flow in the hippocampus may have risen.A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild…
- In 41 obese postmenopausal women over 8 weeks, citrulline alone or with vibration training lowered blood pressures and raised nitric oxide metabolites, and the combination also reduced wave reflection (augmentation index) compared with citrulline alone.Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postm…
- In 41 obese postmenopausal women with high blood pressure, 8 weeks of citrulline plus vibration training lowered aortic stiffness more than the other groups and increased leg muscle mass, while all groups lowered leg artery stiffness.Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function i…
- In 40 men with diabetes and erectile dysfunction, a daily blend containing nicotinic acid, alone or with vardenafil, improved erection scores over 12 weeks, with the blend plus vardenafil giving the largest gain; the study was small and the nicotinic acid dose was not stated.Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectil…
- In 40 children having heart surgery, 5 doses of oral citrulline raised blood citrulline and arginine, but blood pressure and pulmonary hypertension (3 of 20 vs 6 of 20 on placebo) did not differ significantly.Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline.
- In 40 adults with high blood pressure, a single 6 g dose of citrulline malate combined with treadmill exercise increased the post-exercise blood pressure drop and left no non-responders for several measures.Inter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24…
- In 38 patients with bypass graft narrowing, extended-release niacin for 12 months did not significantly change blood vessel function (reactive hyperemia) or carotid artery thickness versus placebo, but did increase endothelial progenitor cell mobilization.Effect of Extended-Release Niacin on Carotid Intima Media Thickness, Reactive Hyperemia, and Endothelial Progenitor Cell…
- In 37 women having IVF, oral L-arginine was linked to fewer good quality embryos and a lower pregnancy rate than placebo, while higher follicle fluid nitric oxide products matched lower blood flow resistance in ovarian arteries.Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study.
- A single 3 gram dose of L-arginine taken before recovery from a treadmill workout did not change heart rate variability or heart recovery in 37 healthy young men, compared with placebo.Acute effects of l-arginine intake on heart rate variability after a submaximal exercise test in healthy men: randomized…
- In 36 pregnant women with chronic high blood pressure, 6 g of L-citrulline a day for 8 weeks raised blood levels of citrulline and arginine but did not change blood pressure or uterine artery blood flow compared with placebo.CHronic hypERtension and L-citRulline studY (CHERRY): an Early-Phase Randomised Controlled Trial in Pregnancy.
- In 35 people with high blood pressure, a single 6 g dose of L-arginine improved artery widening in the arm (from 1.7% to 5.9%) 1.5 hours later, while placebo did not.Oral L-arginine improves endothelial dysfunction in patients with essential hypertension.
- A single 3 gram dose of L-arginine did not speed heart rate or blood pressure recovery after submaximal exercise in 32 healthy active men compared with placebo.L-Arginine Supplementation Did Not Impact the Rapid Recovery of Cardiovascular and Autonomic Function Following Exercise…
- In 30 men with metabolic syndrome, 1500 mg daily of extended-release niacin for 6 weeks raised adiponectin but did not improve endothelial function compared with placebo.Extended-release niacin raises adiponectin and leptin.
- In 30 elderly volunteers, 200 mg daily nicotinic acid with 800 mg pentifylline for two months improved overall brain blood flow on scans compared with placebo.SPECT monitoring of improved cerebral blood flow during long-term treatment of elderly patients with nootropic drugs.
- In 30 healthy young adults, a single 3 g dose of L-arginine did not enhance artery widening or exercise performance compared with placebo around resistance exercise.Endothelial, Cardiovascular, and Performance Responses to L-Arginine Intake and Resistance Exercise.
- In 30 young male athletes, a single dose of 8 g L-citrulline-malate with 3 g L-arginine did not change biceps muscle blood flow, muscle size or muscle pump compared with placebo.New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomiz…
- In 27 young adults with high cholesterol, taking 7 grams of L-arginine three times daily for 4 weeks improved the dilation of the brachial artery in response to increased blood flow compared with placebo.Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.
- In 27 recreationally active men, a single 8 gram dose of citrulline malate did not improve blood flow, energy use, or performance during maximal leg extension exercise compared with placebo.Effects of Citrulline Malate and Beetroot Juice Supplementation on Blood Flow, Energy Metabolism, and Performance During…
- In 27 recreationally active men, 8 g of citrulline malate did not significantly change resting blood pressure, leg blood flow, or energy efficiency during leg exercise compared with placebo.Effects of Citrulline Malate and Beetroot Juice Supplementation on Energy Metabolism and Blood Flow During Submaximal Re…
- In 26 people with non-blocked coronary artery disease, 3 grams of L-arginine three times daily for 6 months improved coronary blood flow response and symptoms compared with placebo.Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans.
- In women with polycystic ovary syndrome, 12 weeks of niacin with laropiprant did not improve blood vessel function or inflammation markers compared with placebo, and it worsened blood sugar response after meals.Postprandial effects of long-term niacin/laropiprant use on glucose and lipid metabolism and on cardiovascular risk in p…
- Four weeks of an L-arginine-based multi ingredient product improved fasting blood vessel function in 25 adults with high blood pressure and high homocysteine, compared with placebo, though blood pressure differences were not significant.Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypert…
- In 25 older adults, 6 g of L-citrulline a day for 2 weeks raised leg blood flow during exercise by about 11% in men but not in women, and the effect in men disappeared after adjusting for baseline diastolic blood pressure.Does l-citrulline supplementation improve exercise blood flow in older adults?
- In 25 postmenopausal women with high blood pressure, 10 g of L-citrulline a day for 4 weeks improved blood vessel dilation and lowered aortic diastolic and mean blood pressure compared with placebo.Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women.
- In 25 trained young men, eight days of a citrulline and glutathione blend (2 grams of citrulline) raised blood flow in the arm 30 minutes after exercise compared with placebo and increased blood citrulline and arginine levels; the abstract does not report the treadmill endurance results.The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males.
- In 24 healthy young adults, a single dose of Nitrosigine (1.5 g) or citrulline malate (8 g) raised blood vessel dilation by 31% and 34% an hour later, compared with a 2% drop on placebo.Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults.
- In 24 healthy adults aged 60 to 70, one month of a daily drink with 6 grams of citrulline and nitrate lowered mean blood pressure by 3.3 mmHg and raised maximal cycling power by 5.2% versus placebo, but did not change other vascular measures or knee exercise performance.Effect of chronic nitrate and citrulline supplementation on vascular function and exercise performance in older individu…
- In 24 healthy young adults, 6 g of citrulline plus nitrate daily for 2 months with exercise training increased knee muscle strength more than placebo, but did not improve blood vessel function or aerobic performance.Synergetic Effect of NO Precursor Supplementation and Exercise Training.
- In 24 hypertensive postmenopausal women, 10 g of L-citrulline daily for 4 weeks improved blood vessel function in the leg, and adding slow low-intensity resistance training for 8 weeks further increased leg muscle mass and leg strength compared with placebo plus training.Combined L-Citrulline Supplementation and Slow Velocity Low-Intensity Resistance Training Improves Leg Endothelial Funct…
- In 22 people, a single 6 gram dose of citrulline taken 1 or 2 hours before exercise did not improve exercise performance or blood vessel flow compared with placebo.The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance.
- In 22 postmenopausal women, 10 g of L-citrulline daily for 4 weeks reduced the rise in aortic systolic pressure and pressure waves triggered by muscle fatigue compared with placebo.L-Citrulline supplementation attenuates aortic pressure and pressure waves during metaboreflex activation in postmenopau…
- In 22 hypertensive postmenopausal women, 10 grams of L-citrulline daily for 4 weeks improved artery widening, blood flow during arm exercise, and muscle oxygenation compared with placebo, and lowered aortic systolic blood pressure at rest.L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensiv…
- In 21 healthy postmenopausal women, 100% watermelon juice for 4 weeks did not change blood vessel function or blood pressure compared with placebo juice.Daily 100% watermelon juice consumption and vascular function among postmenopausal women: A randomized controlled trial.
- In 10 people with type 1 diabetes and 10 healthy people, an L-arginine infusion increased pulsing blood flow in the back of the eye and lowered blood pressure similarly in both groups.Nitric oxide and ocular blood flow in patients with IDDM.
- A single dose of L-arginine did not increase leg artery blood flow or muscle strength compared with placebo in 20 active older women.L-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older wom…
- In 19 HIV-infected adults with low HDL cholesterol, extended-release niacin titrated up to 1500 mg nightly for 12 weeks improved blood vessel dilation compared with the control group, which received no placebo.Short-term effects of extended-release niacin on endothelial function in HIV-infected patients on stable antiretroviral …
- In 19 older adults with diabetes or high blood pressure, 4 days of L-arginine worsened small blood vessel function in the fingers compared with placebo and did not help thinking skills.Arginine impairs endothelial and executive function in older subjects with cardiovascular risk.
- In 18 adults with low HDL cholesterol, 1 g daily extended-release niacin for one week increased blood vessel widening by about 4.5% compared with the start, though there was no difference from the add-on drug laropiprant and the study had no placebo arm.Short-term effects of extended-release niacin with and without the addition of laropiprant on endothelial function in in…
- In 18 critically ill people with septic shock, 72 hours of intravenous L-arginine did not improve small blood vessel blood flow or organ function compared with an alanine control, despite raising nitric oxide production.A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism.
- In 18 abdominally obese men, adding 0.8 to 3.0 g of L-arginine to beetroot powder did not improve blood vessel flow-mediated dilation after a high-fat meal compared with meals without it.Effects of Beetroot Powder with or without L-Arginine on Postprandial Vascular Endothelial Function: Results of a Random…
- In healthy adults given intravenous L-arginine, the kidney blood flow drop caused by angiotensin II was not reduced compared with placebo, although L-arginine alone raised kidney blood flow.Exogenous L-arginine does not affect angiotensin II-induced renal vasoconstriction in man.
- Two weeks of L-arginine, dehydrated beetroot, or placebo did not improve blood vessel function in 17 people with chronic obstructive lung disease.Evaluating the impact of short-term nitrate-rich dietary supplementation on endothelial function in COPD: A randomized c…
- In 17 healthy young adults, two weeks of daily watermelon juice, compared with a calorie-matched placebo drink, improved blood vessel widening and small-vessel blood flow during a blood sugar spike; the citrulline amount was not stated.Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adul…
- In 16 young men taking 3.2 to 9.6 grams of L-arginine daily for 4 days, muscle endurance, nitric oxide levels and blood vessel function did not improve compared with placebo.Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Cr…
- In 16 middle-aged and older adults with type 2 diabetes, 6 g of citrulline daily for 4 weeks improved blood vessel function and calf muscle strength compared with placebo.Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type…
- In 16 adults with type 2 diabetes, four weeks of 6 grams of citrulline daily improved blood vessel function, arterial stiffness, aortic blood pressure, and blood sugar compared with placebo, both fasting and during a blood sugar spike.Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fast…
- In 16 overweight men, 6 g of citrulline daily for 14 days blunted rises in aortic blood pressure and arterial stiffness during handgrip exercise and a cold-stress test compared with placebo.l-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex…
- In 16 children having heart surgery with bypass, citrulline taken around the operation was linked with fewer readings of high lung artery pressure afterward than in children who did not take it.Efficacy of citrulline supplementation to decrease the risk of pulmonary hypertension after congenital heart disease sur…
- In 15 a med-treated adults with type 2 diabetes, 1500 mg daily of prolonged-release niacin for 20 weeks improved forearm blood flow response and small artery stiffness compared with no added treatment.Read the study on PubMed (20667937) →
- In 15 men, a single 6 g dose of L-arginine increased blood volume in the arm muscles during recovery from exercise but did not improve strength compared with placebo.Acute l-arginine supplementation increases muscle blood volume but not strength performance.
- In 15 middle-aged men with stiff arteries, seven days of 5.6 grams of citrulline daily reduced arterial stiffness compared with placebo, independent of blood pressure, which did not change.Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men.
- In 15 hypertensive postmenopausal women, a single 6 g dose of L-citrulline blunted the rise in aortic systolic pressure during exercise combined with a cold stimulus compared with placebo.Acute Citrulline Blunts Aortic Systolic Pressure during Exercise and Sympathoactivation in Hypertensive Postmenopausal W…
- In 14 hemodialysis patients, a high-calcium dialysis bath raised blood calcium and increased arterial stiffness during treatment, while a low-calcium bath did not.Arterial stiffness alterations during hemodialysis: the role of dialysate calcium.
- In 12 adults with age-related macular degeneration, a single oral dose of 250 or 500 mg niacin increased choroidal blood volume by 24% at 30 minutes versus placebo, but blood velocity fell, so overall choroidal blood flow did not change.Effect of niacin on the choroidal circulation of patients with age related macular degeneration.
- In 12 adults with age-related macular degeneration, a single dose of niacin widened an inferior temporal retinal artery by about 5 to 6% at 30 and 90 minutes compared with placebo.Effect of niacin on retinal vascular diameter in patients with age-related macular degeneration.
- In 12 healthy adults over 70, 8 g of L-arginine twice daily for 14 days improved brachial artery widening compared with placebo.Oral L-arginine improves endothelial function in healthy individuals older than 70 years.
- In 12 healthy lean adults during an insulin clamp, an infusion of L-arginine raised blood flow and glucose uptake compared with saline, while D-arginine had no effect.L-arginine but not D-arginine stimulates insulin-mediated glucose uptake.
- In 12 healthy volunteers, a 30-minute intravenous infusion of L-arginine increased blood flow in the choroid layer of the eye compared with placebo.Intravenous administration of L-arginine increases retinal and choroidal blood flow.
- In 12 obese postmenopausal women with high blood pressure, 6 g per day of citrulline and arginine from watermelon for 6 weeks lowered arterial stiffness and aortic systolic pressure compared with placebo in this crossover trial.Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women.
- In 12 healthy men, a single 6 g dose of L-citrulline raised exhaled nitric oxide about 19% versus placebo, but did not change breathing muscle oxygenation or breathing performance.Acute L-Citrulline Supplementation Increases Nitric Oxide Bioavailability but Not Inspiratory Muscle Oxygenation and Res…
- In 12 healthy volunteers, a single dose of microencapsulated watermelon rind, which raised blood citrulline, restored blood vessel flexibility lost after temporary blood flow blockage, compared with placebo.The effect of microencapsulated watermelon rind (Citrullus lanatus) and beetroot (Beta vulgaris L.) ingestion on ischemi…
- In 10 adults with high blood pressure taking meds, a single 8 gram dose of L-arginine taken before a treadmill session led to a larger drop in systolic blood pressure afterward than placebo.A Single Dosage of l-Arginine Oral Supplementation Induced Post-Aerobic Exercise Hypotension in Hypertensive Patients.
- In 10 healthy men, 6 g per day of L-citrulline for 7 days lowered blood pressure and improved oxygen uptake speed and total work in a severe-intensity cycling test compared with placebo.l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.
- In 9 healthy adults, a single 500 mg oral dose of nicotinic acid increased skin blood flow more strongly than acipimox, and raised urinary prostacyclin metabolite levels more than doubled.Acipimox stimulates skin blood flow by a cyclo-oxygenase-dependent mechanism.
- In 8 healthy young men, a single 10 gram arginine drink taken with resistance exercise did not increase thigh muscle blood flow or muscle protein synthesis compared with a control drink.Bolus arginine supplementation affects neither muscle blood flow nor muscle protein synthesis in young men at rest or af…
- In 8 healthy men, a single 30 gram intravenous L-arginine dose lowered blood pressure and resistance in the blood vessels, while a single 6 gram dose given by vein or by mouth did not significantly change blood pressure.L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.
- In 7 healthy adults, nicotinic acid taken for two weeks (500 mg then 1 g daily) lowered insulin sensitivity but did not change 24-hour blood pressure compared with placebo.Effects of nicotinic acid on insulin sensitivity and blood pressure in healthy subjects.
- In 6 patients with advanced leg artery disease, 150 mg daily nicotinic acid for 2 weeks did not change muscle blood flow during exercise compared with placebo, while dipyridamole did.Effect of nicotinic acid and dipyridamole on tissue blood flow in peripheral vascular disease.
- Extended-release niacin increased blood flow in the skin causing flushing, and adding laropiprant reduced that flushing and skin blood flow; this is a skin effect rather than heart blood flow.Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1.
- In cold-exposed men given oral nicotinic acid, blood flow to brown fat did not change compared with control, although brown fat fuel burning and glucose uptake were reduced.Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases…
- A single 10 g oral dose of L-arginine taken with carbohydrate did not change blood glucose, insulin, forearm blood flow or blood pressure in healthy males, whether rested or after exercise.L-arginine ingestion after rest and exercise: effects on glucose disposal.
- In people with heart failure from blocked arteries, infusions of L-arginine and vitamin C were studied for effects on nerve control of blood vessels, and healthy people showed a clear ability to adjust vessel resistance that the heart failure patients lacked.Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic car…
- In young heart transplant recipients with high blood pressure, oral L-arginine was reported to reverse blood vessel inner lining dysfunction and lower high blood pressure.Effect of oral L-arginine on oxidant stress, endothelial dysfunction, and systemic arterial pressure in young cardiac tr…
- In a double-blind crossover trial in people with primary Raynaud's phenomenon, 8 grams of L-arginine daily for 28 days did not change finger blood vessel dilation compared with placebo.Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud's phenomenon.
- An intravenous infusion of L-arginine reduced blood platelet clumping, with the effect linked to nitric oxide released inside platelets.L-arginine infusion decreases platelet aggregation through an intraplatelet nitric oxide release.
- In resistance-trained men taking 2 grams of citrulline plus glutathione daily for 7 days, blood markers of nitric oxide production were higher 30 minutes after exercise than with placebo; the study also had rat and cell parts.Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide …
- In 55 people with heart disease risk factors, a 30 g L-arginine infusion raised brain artery blood flow speed by about 28%, with a greater response in those with prior stroke or mini-stroke (29%) than those without (21%).L-arginine-mediated vasoreactivity in patients with a risk of stroke.
- In 25 people with a hereditary small vessel disease and 24 controls, an L-arginine challenge caused a larger blood vessel widening response in the patients, which suggests impaired vessel lining function rather than a benefit.Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL.
- In 30 patients with schizophrenia and 17 healthy controls, a single 200 mg niacin dose caused a slower skin temperature rise in patients, showing slower blood vessel dilation, and this study did not test a treatment benefit.Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls.
- In 36 people with hypertension and 8 healthy controls, L-arginine infused directly into the arm further increased acetylcholine-triggered blood flow in hypertensive patients.Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension.
- In 43 people recovering from hospitalized COVID-19, 4 grams of citrulline daily for three months lowered a blood vessel inflammation marker (ICAM-1) and increased 6-minute walk distance compared with controls, in an open-label trial.Effect of L-Citrulline Supplementation on Endothelial Function and Body Composition in Post-COVID-19 Syndrome: A Randomi…
- In 20 adults with schizophrenia and 20 healthy controls, skin blood flow response to niacin applied to the forearm was reduced in schizophrenia, and this was linked to fatty acid levels in only some ways; no supplement was taken by mouth.Niacin sensitivity and the arachidonic acid pathway in schizophrenia.
- In 29 healthy adults, taking a med beforehand reduced the skin flushing caused by higher doses of nicotinic acid, suggesting prostaglandins drive the flush; this did not show any heart blood flow benefit.Read the study on PubMed (7060328) →
- In 29 pregnant women, a single intravenous infusion of 30 grams of L-arginine lowered blood pressure in both healthy and preeclamptic women, with a larger drop in those with preeclampsia; this was an arginine infusion, not citrulline.L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release.
- In 13 people with familial high cholesterol and 13 controls, the study found tetrahydrobiopterin restored blood vessel function in the forearm; the abstract does not report a benefit from L-arginine alone.Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
- In 14 people with high cholesterol and 11 with normal cholesterol, a single L-arginine infusion improved blood flow response in the forearm of the high-cholesterol group but not in the normal group.L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
- A one-hour niacin infusion lowered blood pressure in 10 adults with hypertension but reduced large artery compliance in 11 normotensive adults, so the blood vessel response differed between the two groups.Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects.
- In 10 patients with advanced cancer, a single oral dose of nicotinamide followed by breathing carbogen raised tumor blood flow by 17% at 5 minutes and 22% at 10 minutes, compared with almost no change in 8 control patients.Human tumor blood flow is enhanced by nicotinamide and carbogen breathing.
- Arginine delivered through the skin did not change blood vessel widening in young Black or white women, so it did not explain the reduced skin blood vessel function seen in Black women.Contributions of endothelin-1 and l-arginine to blunted cutaneous microvascular function in young, black women.
- A 30-minute intravenous L-arginine infusion lowered markers of blood vessel damage and oxidative stress in 7 people with hypertension compared with saline.Exogenous l-arginine reduces matrix metalloproteinase-2 and -9 activities and oxidative stress in patients with hyperten…
- In 8 people with chest pain and normal coronary arteries, an infusion of arginine directly into the heart's artery increased blood flow in response to acetylcholine, while it had no effect in 8 control participants.Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris an…
- In 10 healthy men, an intravenous L-arginine infusion over 30 minutes relaxed blood vessels and lowered blood pressure for about an hour, partly through nitric oxide and growth hormone.L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment.
- In 8 healthy adults, a small rise in local blood calcium reduced resting forearm blood flow and blunted the blood-vessel dilation caused by verapamil, which recovered after the infusion stopped.Effect of small increments in plasma calcium concentration on the responsiveness of forearm resistance vessels to verapa…
- In 7 healthy volunteers, a single 1 g oral dose of nicotinic acid increased forearm blood flow about four times, and pretreatment with indomethacin reduced this increase to about one third.Dissociation of the effects of nicotinic acid on vasodilatation and lipolysis by a prostaglandin synthesis inhibitor, in…
- In healthy volunteers, niacin given to widen blood vessels raised the eye response to ear temperature testing above baseline, which is consistent with more inner ear blood flow, though the cool-water test did not fit this pattern.Changes in caloric nystagmus induced by vasodilating drugs.
- In patients with a rare inherited mitochondrial disease (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes), two years of oral L-arginine brought blood vessel function, measured by flow-mediated dilation, back up to the level of controls.Endothelial dysfunction in MELAS improved by l-arginine supplementation.
- In 37 patients with metabolic syndrome, 6 weeks of extended-release niacin improved the ability of HDL cholesterol to protect endothelial cells, with no placebo group in this open-label crossover study.Fenofibrate and extended-release niacin improve the endothelial protective effects of HDL in patients with metabolic syn…
- In 11 children, an arginine infusion lowered blood pressure, and the drop was linked to higher levels of citrulline, consistent with more nitric oxide being made.L-arginine infusion lowers blood pressure in children.
- In 10 adults with MELAS, L-citrulline doses of 10 to 40 g daily caused no dose-limiting toxicity, and cerebral blood flow rose in 7 participants, mostly on the highest dose, though higher doses raised some guanidino compound levels that need further safety checks.L-citrulline treatment of nitric oxide deficiency in MELAS a phase I dose-finding and safety study.
- In 6 patients with liver tumors from colon cancer, one dose of nicotinamide plus breathing carbogen gas increased blood flow inside the tumors but reduced blood flow in the liver and kidneys, and this study did not measure heart blood flow.Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal…
- A single 0.9 gram dose of arginine improved blood vessel dilation in young, trained healthy men, but did not change it in older or less active men.L-arginine as dietary supplement for improving microvascular function.
- In healthy volunteers, infusing calcium into the arm blunted the blood-vessel dilation caused by magnesium, while dilation caused by potassium was not affected.Attenuated vasodilator responses to Mg2+ in young patients with borderline hypertension.
- Nicotinic acid and its esters applied to the skin of healthy volunteers widened skin blood vessels, with the effect depending on the amount reaching the blood vessels; this is a skin effect rather than heart blood flow.Permeation, metabolism and site of action concentration of nicotinic acid derivatives in human skin. Correlation with to…
- In people with a rare inherited mitochondrial disease, two years of oral arginine supplementation restored blood vessel function to control levels and reduced the frequency and severity of stroke-like episodes.MELAS and L-arginine therapy.
- In people with familial amyloid nerve disease, arginine given into the arm's artery caused blood vessels to widen as it did in control participants, although their nitric oxide production was lower and their blood flow was reduced at rest.Role of nitric oxide in the peripheral vessels of patients with familial amyloidotic polyneuropathy (FAP) type I.
- Intra-arterial insulin raised forearm blood flow and arginine transport in healthy people but not in people with type 2 diabetes; no L-arginine supplement was given.Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetes.
Review Totals and Summary
Members OnlyWhat buyers say
Customer feedback specific to this product is limited and mostly comes from enthusiastic fans, so it skews positive. Most reviews sit on the seller's own pages or on Infowars-friendly channels. Buyers on the seller's page praise a noticeable lift in gym energy, faster recovery, a stronger pump and better focus during workouts. Some describe it as making their training feel "supercharged" within a couple of weeks. A Trustpilot reviewer on the Infowars store listed Nitric Boost among a group of products they trust. Another said their partner takes it daily to help keep blood pressure calm and has had no problems since. A video reviewer also talks up its effect on workout performance. A recurring theme is loyalty to the brand. Fans describe the quality as superior and the prices as reasonable. The criticism is mostly about the store, not the capsules. Trustpilot reviewers complain of orders that never shipped after payment, no response from customer service when something went wrong, short shelf life and "dubious" health claims. Skeptics, including independent lab-testing coverage, argue that Infowars supplements are ordinary ingredient blends sold at premium prices. They say the wellness claims go beyond the evidence. Several of these critiques are about the brand as a whole, and none is specific to this product. I found no reliable body of complaints about side effects from this exact capsule. A caution about confusion applies here. A different product called Nitric Boost Ultra, sold at nitricboost.com, has poor ratings. One buyer reported no results after three months and called it a scam. Other reviewers said they could not get a reply from the company. Those reviews don't describe the Infowars product. Many glowing "Nitric Boost" reviews online appear on spammy forum posts and PDF pages that promote the Ultra product, so treat them as unreliable. In short, customers who like it talk about energy, workout stamina and circulation. Doubters raise price, unproven claims and unreliable shipping and support.
Biohacker Summary
Members Only10 of 10 recommend it
Niacin and citrulline are the two main ingredients here, and the panel leans positive on both. On niacin, five of the ten recommend or use it: some for raising NAD levels, one takes enough to flush before a sauna, and others use the niacinamide form for skin, with one dose of 500 milligrams twice a day and another of 15 milligrams in a daily stack; the rest were neutral. On citrulline, most who spoke recommend it as a nitric oxide and blood flow booster for workouts, recovery and mental clarity, with one suggesting it about 30 minutes before a sauna and another citing 1.5 grams a day for mild erectile problems. One panelist warns that citrulline can cause cold sores and canker sores and that not everyone tolerates it. Calcium is a smaller ingredient in this product, and the panel was split, with some recommending it for bones and one warning against calcium carbonate.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Niacin · recommends
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
- Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Mentions that thicker white lines in a different location on nails are usually because of a vitamin B3 (niacin) deficiency.
- Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
- Niacin has been studied for its connection to cholesterol, heart health, mood disorders, and liver function.
- Flushing niacin is the form used to support balanced cholesterol levels, while no-flush versions do not provide the same benefits.
- Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
- Dr. Berg mentions that fermented dairy contains vital nutrients, including calcium.
Dr. Mark Hyman · Niacin · neutral
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Lists niacin as a B vitamin cofactor that helps mitochondrial function.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
- Warns that acid blockers inhibit calcium absorption.
- Lists calcium as another important nutrient that people can be tested for and measured.
- States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
- Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
- Recommends calcium citrate, about 600 milligrams a day, for bone health, noting that much can also be obtained from diet through leafy greens, sesame seeds, tahini, and chia seeds.
- Uses niacinamide as part of a compounded acne cream.
- Mentions that athletic cocktails include amino acids like citrulline to help with recovery and improve physical performance.
- Dr. Hyman notes that while calcium deficiency is not common in terms of blood levels, insufficient intake can lead to osteoporosis as the body pulls calcium from bones. He advises caution with calcium supplementation due to potential heart issues.
Dave Asprey · Citrulline · recommends
- Notes that a 2011 trial found 1.5 g of L-citrulline daily restored normal erectile function in 50% of men with mild ED, and states that it's worth knowing about for mild ED.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
- Notes that niacin has been a standard longevity ingredient since the 1990s.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
- Dave Asprey recommends Joy Mode, an electrolyte packet for sexual performance, to be taken one packet about 45 minutes before sex, as it contains clinical doses of L-citrulline, arginine nitrate, ginseng, and vitamin C to increase nitric oxide levels.
- Dave Asprey recommends Joy Mode, an electrolyte packet for sexual performance, to be taken one packet about 45 minutes before sex, as it contains clinical doses of L-citrulline, arginine nitrate, ginseng, and vitamin C to increase nitric oxide levels.
- Suggests L-citrulline as an amino acid to consider for performance, noting that guys who work out like it.
- Recommends taking 3 g of beta-alanine with creatine to enhance muscle buffering and extend high-intensity capacity for competitive athletes.
- Dave discusses how niacinamide compares as an NAD precursor.
- Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
Siim Land · Citrulline · neutral
- States that L-citrulline can raise arginine availability and support the conventional enzymatic pathway for nitric oxide production, which does not depend on mouth bacteria.
- Lists dairy and sardines as sources of Calcium.
- Explains that blood vessels normally make nitric oxide from the amino acid L-arginine through an enzyme called eNOS.
- Notes that Boron reduces calcium/magnesium loss.
- Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
- Recommends a high calcium intake for bone health.
- Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
- Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
- Places Citrulline in the 'good' tier because this amino acid helps with nitric oxide production, thereby improving blood flow.
- Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
- Places beta-alanine in the 'good tier', stating it's potentially useful for sports performance by buffering lactic acid and produces carnosine for skin anti-aging benefits, but notes it can cause skin itching.
- Recommends niacin as a much cheaper and equally effective NAD booster compared to NMN and NR.
- Warns that niacin, an NAD precursor, can shorten sleep.
Thomas DeLauer · Niacin · uses
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Explains that citrulline, found in watermelon, is converted to arginine, which feeds nitric oxide synthase, amplifying one of the contraction signals that drives glucose into muscle cells, and also helps clear ammonia during exercise, preserving muscle function and accelerating recovery.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Highlights L-citrulline, found richly in watermelon, as an amino acid that feeds into nitric oxide, improving performance, recovery, and reducing muscle soreness by clearing metabolic waste and supporting the urea cycle.
- Recommends beta-alanine, stating it is a rate-limiting precursor to carnosine, which acts as an intracellular pH buffer and improves performance in efforts lasting 1 to 4 minutes.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
- Recommends L-citrulline as it converts to arginine, a precursor to nitric oxide, is calorie-free, doesn't break a fast, and increases plasma nitrite levels.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
- Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
- Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
- Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
- Beta-alanine buffers the burn, allowing for more reps in the 8-15 range.
Ben Greenfield · Niacin · neutral
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Mentions an arginine link to thymus metabolism, noting that immune cells require a lot of arginine.
- Recommends Beta-alanine, explaining it builds up carnosine in muscles, helping buffer acidity during hard efforts.
- Recommends taking citrulline, a pre-workout that vasodilates, about 30 minutes before a sauna session to induce more sweating and aid in detoxification.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Recommends adequate intake of calcium for bone strength.
- Recommends beta-alanine to enhance muscular endurance and improve buffering capacity during high-intensity efforts.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
- Recommends chia and flax seeds as they are rich in arginine, which can help supply nutrients that patients may be lacking.
- Mentions niacin as a natural approach that might be good for plaque regression.
- Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
Peter Attia · Niacin · uses
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Peter Attia, who did not believe in dietary supplements as a collegiate athlete, later dove into understanding the impacts of beta-alanine during grad school.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Recommends citrulline malate, stating it increases blood nitrate levels more than arginine due to better bioavailability, and can enhance performance and potentially stimulate mtor for hypertrophy.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
- Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
- Notes that nitrogen from arginine goes to nitric oxide, which is involved in vasodilation.
- Recalls that a flush from niacin typically occurred with doses of a few grams.
- Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
- Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
- He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
Dr. Rhonda Patrick · Citrulline · neutral
- Supplements like beetroot juice or citrulline can help close that gap, providing both systemic and cerebral benefits through enhanced vascular function.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Notes additional gaps in calcium.
- Recommends beta-alanine for boosting exercise performance, stating it allows one to push harder and longer by buffering muscle burn.
- Recommends citrulline as a blood flow enhancer that boosts nitric oxide, opens up blood vessels, and can improve how one feels during endurance or high-rep sessions, also sharpening mental clarity.
- Lists beta-alanine as a supplement for enhancing exercise performance and recovery.
- Recommends arginine as a blood flow enhancer that boosts nitric oxide, opens up blood vessels, and can improve how one feels during endurance or high-rep sessions, also sharpening mental clarity.
- Discusses citrulline as a blood flow enhancer that can improve performance, noting it has a very pronounced stimulant effect and can cause a physical pump, but can be too powerful for some people.
- Introduces beta-alanine as a fatigue buffer that has been around for a long time, explaining its simple strategy related to maintaining pH levels in muscles.
- Notes that arginine has fallen out of favor as a performance enhancer due to bioavailability issues and concerns about cold sores, with citrulline now being the preferred approach.
- Discusses whether nitric oxide boosters like beetroot, citrulline, and arginine work.
- Discusses why the tingles from beta-alanine might be worth it.
- Discusses whether nitric oxide boosters like beetroot, citrulline, and arginine work.
- States that citrulline may have some benefits for fatigue resistance, especially at a dose of 6 grams.
Andrew Huberman · Niacin · neutral
- Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
- Mentions that in previous episodes, he discussed beta-alanine for moderate-duration work.
- Mentions Arginine in the context of growth hormone supplements.
- Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
- Andrew Huberman warns that L-citrulline can cause vicious cold sores and canker sores, and not everyone tolerates it well.
- Huberman mentions arginine as a nonprescription substance that increases blood flow.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
- Recommends starting beta-alanine at a minimal dosage like 2 grams and gradually increasing by one gram each week to build tolerance and mitigate side effects like skin itching.
- Recommends Arginine for growth hormone.
- Mentions a new meta-analysis showing that citrulline malate can reduce fatigue, increase time to fatigue, and may have small recovery benefits.
- Notes that a med works similarly to citrulline or other pump products in pre-workout supplements.
- Mentions Beta-Alanine in a list of substances.
- Notes that citrulline can improve performance for long bouts of exercise due to vasodilation, but warns that it can increase the likelihood of herpes cold sore outbreaks.
- Discusses beta-alanine as having strong, well-supported effects for improving muscular endurance, anaerobic running capacity, reducing fatigue, and potentially reducing body fat and improving lean mass, with a standard dose of 2 to 5 grams.
Bryan Johnson · Niacin · recommends
- Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends continuing with calcium to support bone health during the follicular phase.
RAL Summary
Members OnlyTier 4 for Circulation
Tier 4 because the arginine, citrulline and niacin in this product are at trace or low doses compared with the amounts that helped in studies, and no reviews could be counted.
- Emerging: not enough evidence to rank higher yet.
- Niacin: trace amount
- L-Arginine: trace amount
- Citrulline: below the dose that worked in studies
- L-Citrulline Malate: trace amount
Where the evidence disagrees: 47 of the 135 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system
Combine with: For the product's actual purpose of blood flow support, pair it with beetroot extract or nitrate sources, vitamin C, and CoQ10 for endothelial and mitochondrial support, magnesium for vascular relaxation, and omega-3 fish oil for cardiovascular health. For the regularity goal, choose a different product: magnesium citrate or oxide, psyllium husk or partially hydrolyzed guar gum for fiber, adequate water, probiotics such as Bifidobacterium lactis BB-12, and prunes or kiwifruit extract. Consult a healthcare provider before combining L-Arginine with blood pressure or erectile dysfunction medications.
Possible side effects: No major side effects reported for this product; in one small study of older adults, a few days of arginine worsened small blood vessel function in the fingers, and in pregnant women with preeclampsia citrulline was linked to higher blood pressure.
Supplement Facts
Calcium 30 mg · Niacin 30 mg NE · L-Arginine 400 mg
| Calcium | 30 mg | |
| Niacin | 30 mg NE | |
| L-Arginine | 400 mg | † |
| L-Arginine Alpha-Ketoglutarate | 400 mg | † |
| L-Citrulline Hydrochloride | 200 mg | † |
| L-Citrulline Malate | 200 mg | † |
| Beta-Alanine | 80 mg | † |
Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide.
Directions: Suggested use: As a dietary supplement, take two (2) capsules once a day. For best results take 20-30 min before a meal with an 8 oz. glass of water or as directed by your healthcare professional.
Label source: NIH label database · Report a label change
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- Supplements for Focus and Mental ClarityArticle · Jun 16, 2026
Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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