InfoWars M.D Nitric Boost Review

Nitric Boost by Infowars M.D is presented on this Limitless America page as a body-building formula with amino acids, intended for strength and power. The page says the formula helps promote the synthesis and discourages the degradation of Nitric Oxide, which the page describes as beneficial for cardiovascular function. It also lists circulation and muscular performance as areas the formula helps promote. The product is listed under the INFOWARS LIFE brand, with SKU 128-NO2-166. The page shows a price of $54.95 and marks the item as out of stock. No reviews have been posted yet, and the page does not list ingredients, serving size, form, or a UPC barcode.

Product Focus: CirculationAlso covers:Heart
Tier ⓘ
Tier 4 · Rank 12
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 12 within Tier 4 for Circulation; 35 of 38 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
35 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
10 of 10

Study, Trial or Testing Result Summary

Members Only135 human studies · 66 improved

22 of these 135 human studies gave the ingredient by drip, injection or inhaler, not by mouth.

135 human studies66 improved47 no effect5,247 people studied

This product contains small amounts of ingredients studied for blood flow, but every one is far below the doses used in research. L-arginine, at 800 milligrams in total across two forms, is a fraction of the 6 grams that helped in some trials. A single 6 gram dose improved artery widening in people with high blood pressure [1], and a review found a small benefit only in people with poor starting vessel function [2]. The largest trial, at 3 grams daily for 6 months, found no benefit [3]. Citrulline, at 400 milligrams in total, is well below the 3 to 10 grams studied. A review of 8 trials found citrulline improved vessel widening in middle-aged and older adults [4], and 10 grams daily helped women with high blood pressure [5], but 6 grams daily did not help healthy women. Niacin at 30 milligrams is a trace amount, while benefits for artery widening appeared at 1500 to 2000 milligrams or more [6], and some trials at those doses found no effect [7]. Calcium studies, all given into a vein, showed no benefit for blood flow [8]. Beta-alanine has no human studies for this goal. Animal and cell studies are never counted.

See all 135 studies →Hide the studies

Review Totals and Summary

Members OnlyWhat buyers say

Customer feedback specific to this product is limited and mostly comes from enthusiastic fans, so it skews positive. Most reviews sit on the seller's own pages or on Infowars-friendly channels. Buyers on the seller's page praise a noticeable lift in gym energy, faster recovery, a stronger pump and better focus during workouts. Some describe it as making their training feel "supercharged" within a couple of weeks. A Trustpilot reviewer on the Infowars store listed Nitric Boost among a group of products they trust. Another said their partner takes it daily to help keep blood pressure calm and has had no problems since. A video reviewer also talks up its effect on workout performance. A recurring theme is loyalty to the brand. Fans describe the quality as superior and the prices as reasonable. The criticism is mostly about the store, not the capsules. Trustpilot reviewers complain of orders that never shipped after payment, no response from customer service when something went wrong, short shelf life and "dubious" health claims. Skeptics, including independent lab-testing coverage, argue that Infowars supplements are ordinary ingredient blends sold at premium prices. They say the wellness claims go beyond the evidence. Several of these critiques are about the brand as a whole, and none is specific to this product. I found no reliable body of complaints about side effects from this exact capsule. A caution about confusion applies here. A different product called Nitric Boost Ultra, sold at nitricboost.com, has poor ratings. One buyer reported no results after three months and called it a scam. Other reviewers said they could not get a reply from the company. Those reviews don't describe the Infowars product. Many glowing "Nitric Boost" reviews online appear on spammy forum posts and PDF pages that promote the Ultra product, so treat them as unreliable. In short, customers who like it talk about energy, workout stamina and circulation. Doubters raise price, unproven claims and unreliable shipping and support.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Niacin and citrulline are the two main ingredients here, and the panel leans positive on both. On niacin, five of the ten recommend or use it: some for raising NAD levels, one takes enough to flush before a sauna, and others use the niacinamide form for skin, with one dose of 500 milligrams twice a day and another of 15 milligrams in a daily stack; the rest were neutral. On citrulline, most who spoke recommend it as a nitric oxide and blood flow booster for workouts, recovery and mental clarity, with one suggesting it about 30 minutes before a sauna and another citing 1.5 grams a day for mild erectile problems. One panelist warns that citrulline can cause cold sores and canker sores and that not everyone tolerates it. Calcium is a smaller ingredient in this product, and the panel was split, with some recommending it for bones and one warning against calcium carbonate.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Niacin · recommends
    • 19 Oct 2026 · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 25 Oct 2026 · Calcium · warns · YouTube ↗
      Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
    • 11 Oct 2026 · recommends · YouTube ↗
      Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
    • 10 Oct 2026 · Calcium · warns · Podcast ↗
      Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
    • 3 Oct 2026 · Calcium · warns · YouTube ↗
      Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
    • 2 Oct 2026 · recommends · YouTube ↗
      States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
    • 27 Sep 2026 · neutral · X ↗
      Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
    • 27 Sep 2026 · Calcium · neutral · X ↗
      Notes that tannins in tea bind calcium, blocking its absorption.
    • 10 Sep 2026 · neutral · Facebook ↗
      Mentions that thicker white lines in a different location on nails are usually because of a vitamin B3 (niacin) deficiency.
    • 10 Sep 2026 · Calcium · neutral · Facebook ↗
      Indicates that horizontal thin white lines near the base of the nails are indicative of low calcium.
    • 6 Sep 2026 · neutral · X ↗
      Niacin has been studied for its connection to cholesterol, heart health, mood disorders, and liver function.
    • 5 Sep 2026 · warns · X ↗
      Flushing niacin is the form used to support balanced cholesterol levels, while no-flush versions do not provide the same benefits.
    • 4 Sep 2026 · Calcium · warns · Facebook ↗
      Warns that calcium carbonate can build up in the arteries and kidneys and increase the risk of a heart attack.
    • 3 Sep 2026 · Calcium · neutral · Facebook ↗
      Dr. Berg mentions that fermented dairy contains vital nutrients, including calcium.
  • Dr. Mark Hyman · Niacin · neutral
    • 30 Sep 2026 · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 20 Aug 2026 · Calcium · recommends · YouTube ↗
      Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
    • 17 Jun 2026 · Calcium · neutral · YouTube ↗
      States that green leafy vegetables are great sources of calcium.
    • 3 Nov 2025 · Calcium · neutral · Podcast ↗
      Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
    • 8 Oct 2025 · neutral · YouTube ↗
      Lists niacin as a B vitamin cofactor that helps mitochondrial function.
    • 17 Sep 2025 · Calcium · warns · YouTube ↗
      Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
    • 14 May 2025 · Calcium · warns · YouTube ↗
      Warns that acid blockers inhibit calcium absorption.
    • 2 Apr 2025 · Calcium · recommends · YouTube ↗
      Lists calcium as another important nutrient that people can be tested for and measured.
    • 12 Mar 2025 · Calcium · warns · YouTube ↗
      States that high doses of calcium supplementation in the elderly were not really impacting bone density, as osteopenic patients still became osteoporotic.
    • 29 Nov 2024 · Calcium · warns · YouTube ↗
      Warns that meds (meds) impair the absorption of calcium, which increases the risk of hip fractures and osteoporosis.
    • 15 Nov 2024 · Calcium · recommends · YouTube ↗
      Recommends calcium citrate, about 600 milligrams a day, for bone health, noting that much can also be obtained from diet through leafy greens, sesame seeds, tahini, and chia seeds.
    • 6 Nov 2024 · uses · YouTube ↗
      Uses niacinamide as part of a compounded acne cream.
    • 6 Nov 2024 · Citrulline · neutral · YouTube ↗
      Mentions that athletic cocktails include amino acids like citrulline to help with recovery and improve physical performance.
    • 27 Sep 2024 · Calcium · warns · YouTube ↗
      Dr. Hyman notes that while calcium deficiency is not common in terms of blood levels, insufficient intake can lead to osteoporosis as the body pulls calcium from bones. He advises caution with calcium supplementation due to potential heart issues.
  • Dave Asprey · Citrulline · recommends
    • 25 Sep 2026 · recommends · Facebook ↗
      Notes that a 2011 trial found 1.5 g of L-citrulline daily restored normal erectile function in 50% of men with mild ED, and states that it's worth knowing about for mild ED.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 16 Jun 2026 · Calcium · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
    • 12 Jun 2026 · Calcium · neutral · Instagram ↗
      Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
    • 12 Jun 2026 · Calcium · neutral · X ↗
      Notes that people take calcium for their bones.
    • 30 May 2026 · Niacin · recommends · YouTube ↗
      Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
    • 15 May 2026 · Niacin · neutral · X ↗
      Notes that niacin has been a standard longevity ingredient since the 1990s.
    • 14 May 2026 · Calcium · warns · YouTube ↗
      Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
    • 9 Apr 2026 · recommends · YouTube ↗
      Dave Asprey recommends Joy Mode, an electrolyte packet for sexual performance, to be taken one packet about 45 minutes before sex, as it contains clinical doses of L-citrulline, arginine nitrate, ginseng, and vitamin C to increase nitric oxide levels.
    • 9 Apr 2026 · Arginine · recommends · YouTube ↗
      Dave Asprey recommends Joy Mode, an electrolyte packet for sexual performance, to be taken one packet about 45 minutes before sex, as it contains clinical doses of L-citrulline, arginine nitrate, ginseng, and vitamin C to increase nitric oxide levels.
    • 12 Mar 2026 · neutral · YouTube ↗
      Suggests L-citrulline as an amino acid to consider for performance, noting that guys who work out like it.
    • 7 Mar 2026 · Beta-alanine · recommends · YouTube ↗
      Recommends taking 3 g of beta-alanine with creatine to enhance muscle buffering and extend high-intensity capacity for competitive athletes.
    • 17 Feb 2026 · Niacin · neutral · Podcast ↗
      Dave discusses how niacinamide compares as an NAD precursor.
    • 17 Feb 2026 · Niacin · neutral · YouTube ↗
      Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
  • Siim Land · Citrulline · neutral
    • 23 Sep 2026 · neutral · YouTube ↗
      States that L-citrulline can raise arginine availability and support the conventional enzymatic pathway for nitric oxide production, which does not depend on mouth bacteria.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 23 Sep 2026 · Arginine · neutral · YouTube ↗
      Explains that blood vessels normally make nitric oxide from the amino acid L-arginine through an enzyme called eNOS.
    • 14 Aug 2026 · Calcium · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 15 Feb 2026 · Niacin · recommends · TikTok ↗
      Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
    • 14 Feb 2026 · Calcium · recommends · TikTok ↗
      Recommends a high calcium intake for bone health.
    • 12 Feb 2026 · Niacin · recommends · Instagram ↗
      Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
    • 17 Jan 2026 · Niacin · neutral · Instagram ↗
      Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
    • 28 Dec 2025 · neutral · YouTube ↗
      Places Citrulline in the 'good' tier because this amino acid helps with nitric oxide production, thereby improving blood flow.
    • 28 Dec 2025 · Niacin · neutral · YouTube ↗
      Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
    • 28 Dec 2025 · Calcium · warns · YouTube ↗
      Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
    • 28 Dec 2025 · Beta-alanine · recommends · YouTube ↗
      Places beta-alanine in the 'good tier', stating it's potentially useful for sports performance by buffering lactic acid and produces carnosine for skin anti-aging benefits, but notes it can cause skin itching.
    • 11 Dec 2025 · Niacin · recommends · YouTube ↗
      Recommends niacin as a much cheaper and equally effective NAD booster compared to NMN and NR.
    • 25 Oct 2025 · Niacin · warns · Instagram ↗
      Warns that niacin, an NAD precursor, can shorten sleep.
  • Thomas DeLauer · Niacin · uses
    • 5 Sep 2026 · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 18 Sep 2026 · Calcium · neutral · Facebook ↗
      Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
    • 24 Aug 2026 · Citrulline · recommends · YouTube ↗
      Explains that citrulline, found in watermelon, is converted to arginine, which feeds nitric oxide synthase, amplifying one of the contraction signals that drives glucose into muscle cells, and also helps clear ammonia during exercise, preserving muscle function and accelerating recovery.
    • 12 Aug 2026 · Calcium · recommends · YouTube ↗
      Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
    • 4 Jul 2026 · Citrulline · recommends · YouTube ↗
      Highlights L-citrulline, found richly in watermelon, as an amino acid that feeds into nitric oxide, improving performance, recovery, and reducing muscle soreness by clearing metabolic waste and supporting the urea cycle.
    • 3 Jul 2026 · Beta-alanine · recommends · YouTube ↗
      Recommends beta-alanine, stating it is a rate-limiting precursor to carnosine, which acts as an intracellular pH buffer and improves performance in efforts lasting 1 to 4 minutes.
    • 30 Jun 2026 · Calcium · neutral · YouTube ↗
      Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
    • 24 Jun 2026 · neutral · YouTube ↗
      Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
    • 19 Jun 2026 · Citrulline · recommends · YouTube ↗
      Recommends L-citrulline as it converts to arginine, a precursor to nitric oxide, is calorie-free, doesn't break a fast, and increases plasma nitrite levels.
    • 19 Jun 2026 · Calcium · neutral · YouTube ↗
      Mentions that magnesium and calcium should not be taken together as they cancel each other out.
    • 13 Jun 2026 · Calcium · warns · YouTube ↗
      Tries to get multivitamins without calcium or with a low amount, as he believes supplemental calcium impacts the absorption of other vitamins and minerals and is not as beneficial as hyped. He cautions against it for most people due to the risk of coronary artery calcification.
    • 12 Jun 2026 · Calcium · recommends · YouTube ↗
      Recommends getting calcium from dairy sources like milk, yogurt, kefir, and cheese in the morning to support neurotransmitter synchronization crucial for deep and REM sleep, noting that low dietary calcium is linked to insomnia.
    • 20 May 2026 · Calcium · warns · YouTube ↗
      Warns that calcium competes with magnesium for the same absorption channels, advising to separate magnesium intake from calcium supplements or dairy by at least an hour or two.
    • 18 May 2026 · Beta-alanine · neutral · Facebook ↗
      Beta-alanine buffers the burn, allowing for more reps in the 8-15 range.
  • Ben Greenfield · Niacin · neutral
    • 29 Aug 2026 · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 10 Oct 2026 · Arginine · neutral · YouTube ↗
      Mentions an arginine link to thymus metabolism, noting that immune cells require a lot of arginine.
    • 27 Sep 2026 · Beta-alanine · recommends · Facebook ↗
      Recommends Beta-alanine, explaining it builds up carnosine in muscles, helping buffer acidity during hard efforts.
    • 23 Jul 2026 · Citrulline · recommends · YouTube ↗
      Recommends taking citrulline, a pre-workout that vasodilates, about 30 minutes before a sauna session to induce more sweating and aid in detoxification.
    • 9 May 2026 · Calcium · neutral · YouTube ↗
      Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
    • 6 May 2026 · Calcium · neutral · X ↗
      Mentions calcium as a common deficiency.
    • 25 Apr 2026 · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 18 Apr 2026 · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
    • 12 Apr 2026 · Calcium · recommends · Facebook ↗
      Recommends adequate intake of calcium for bone strength.
    • 3 Mar 2026 · Beta-alanine · recommends · Facebook ↗
      Recommends beta-alanine to enhance muscular endurance and improve buffering capacity during high-intensity efforts.
    • 13 Feb 2026 · Calcium · uses · YouTube ↗
      Is using calcium chloride mixed with PRP before injecting for the P-shot.
    • 17 Jan 2026 · Arginine · recommends · YouTube ↗
      Recommends chia and flax seeds as they are rich in arginine, which can help supply nutrients that patients may be lacking.
    • 8 Jan 2026 · neutral · YouTube ↗
      Mentions niacin as a natural approach that might be good for plaque regression.
    • 22 Nov 2025 · Calcium · stopped · YouTube ↗
      Advises people to stop taking calcium supplements as part of the Root Cause Protocol.
  • Peter Attia · Niacin · uses
    • 29 Jun 2025 · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 4 Jan 2026 · Beta-alanine · uses · YouTube ↗
      Peter Attia, who did not believe in dietary supplements as a collegiate athlete, later dove into understanding the impacts of beta-alanine during grad school.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 22 Oct 2024 · Calcium · recommends · YouTube ↗
      Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
    • 21 Oct 2024 · Calcium · recommends · YouTube ↗
      Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
    • 25 May 2024 · Citrulline · recommends · YouTube ↗
      Recommends citrulline malate, stating it increases blood nitrate levels more than arginine due to better bioavailability, and can enhance performance and potentially stimulate mtor for hypertrophy.
    • 30 Jan 2023 · stopped · YouTube ↗
      Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
    • 7 Nov 2022 · stopped · YouTube ↗
      Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
    • 26 Sep 2022 · Arginine · neutral · YouTube ↗
      Notes that nitrogen from arginine goes to nitric oxide, which is involved in vasodilation.
    • 1 Aug 2022 · neutral · YouTube ↗
      Recalls that a flush from niacin typically occurred with doses of a few grams.
    • 18 Jul 2022 · Calcium · neutral · YouTube ↗
      Notes that bone is 50 to 70 percent mineral, with calcium being the predominant mineral, and virtually all of the body's calcium is contained within bone.
    • 13 Jun 2022 · warns · YouTube ↗
      Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
    • 13 Jun 2022 · neutral · Podcast ↗
      He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
  • Dr. Rhonda Patrick · Citrulline · neutral
    • 30 Apr 2025 · neutral · Instagram ↗
      Supplements like beetroot juice or citrulline can help close that gap, providing both systemic and cerebral benefits through enhanced vascular function.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 9 Jan 2026 · Calcium · neutral · Facebook ↗
      Notes additional gaps in calcium.
    • 2 May 2025 · Beta-alanine · recommends · Facebook ↗
      Recommends beta-alanine for boosting exercise performance, stating it allows one to push harder and longer by buffering muscle burn.
    • 29 Apr 2025 · recommends · Facebook ↗
      Recommends citrulline as a blood flow enhancer that boosts nitric oxide, opens up blood vessels, and can improve how one feels during endurance or high-rep sessions, also sharpening mental clarity.
    • 29 Apr 2025 · Beta-alanine · neutral · Facebook ↗
      Lists beta-alanine as a supplement for enhancing exercise performance and recovery.
    • 29 Apr 2025 · Arginine · recommends · Facebook ↗
      Recommends arginine as a blood flow enhancer that boosts nitric oxide, opens up blood vessels, and can improve how one feels during endurance or high-rep sessions, also sharpening mental clarity.
    • 28 Apr 2025 · neutral · YouTube ↗
      Discusses citrulline as a blood flow enhancer that can improve performance, noting it has a very pronounced stimulant effect and can cause a physical pump, but can be too powerful for some people.
    • 28 Apr 2025 · Beta-alanine · neutral · YouTube ↗
      Introduces beta-alanine as a fatigue buffer that has been around for a long time, explaining its simple strategy related to maintaining pH levels in muscles.
    • 28 Apr 2025 · Arginine · stopped · YouTube ↗
      Notes that arginine has fallen out of favor as a performance enhancer due to bioavailability issues and concerns about cold sores, with citrulline now being the preferred approach.
    • 22 Apr 2025 · neutral · Podcast ↗
      Discusses whether nitric oxide boosters like beetroot, citrulline, and arginine work.
    • 22 Apr 2025 · Beta-alanine · neutral · Podcast ↗
      Discusses why the tingles from beta-alanine might be worth it.
    • 22 Apr 2025 · Arginine · neutral · Podcast ↗
      Discusses whether nitric oxide boosters like beetroot, citrulline, and arginine work.
    • 27 Aug 2024 · neutral · YouTube ↗
      States that citrulline may have some benefits for fatigue resistance, especially at a dose of 6 grams.
  • Andrew Huberman · Niacin · neutral
    • 1 Jul 2024 · neutral · Instagram ↗
      Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
    • 17 Apr 2025 · Beta-alanine · neutral · YouTube ↗
      Mentions that in previous episodes, he discussed beta-alanine for moderate-duration work.
    • 6 Mar 2025 · Arginine · neutral · Podcast ↗
      Mentions Arginine in the context of growth hormone supplements.
    • 1 Jul 2024 · recommends · YouTube ↗
      Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
    • 14 Aug 2023 · Citrulline · warns · YouTube ↗
      Andrew Huberman warns that L-citrulline can cause vicious cold sores and canker sores, and not everyone tolerates it well.
    • 14 Aug 2023 · Arginine · neutral · YouTube ↗
      Huberman mentions arginine as a nonprescription substance that increases blood flow.
    • 6 Mar 2023 · Calcium · neutral · Podcast ↗
      Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
    • 22 Feb 2023 · Beta-alanine · recommends · YouTube ↗
      Recommends starting beta-alanine at a minimal dosage like 2 grams and gradually increasing by one gram each week to build tolerance and mitigate side effects like skin itching.
    • 9 Jan 2023 · Arginine · recommends · Podcast ↗
      Recommends Arginine for growth hormone.
    • 7 Nov 2022 · Citrulline · neutral · YouTube ↗
      Mentions a new meta-analysis showing that citrulline malate can reduce fatigue, increase time to fatigue, and may have small recovery benefits.
    • 11 Apr 2022 · Citrulline · neutral · YouTube ↗
      Notes that a med works similarly to citrulline or other pump products in pre-workout supplements.
    • 7 Jun 2021 · Beta-alanine · neutral · Podcast ↗
      Mentions Beta-Alanine in a list of substances.
    • 31 May 2021 · Citrulline · warns · YouTube ↗
      Notes that citrulline can improve performance for long bouts of exercise due to vasodilation, but warns that it can increase the likelihood of herpes cold sore outbreaks.
    • 31 May 2021 · Beta-alanine · recommends · YouTube ↗
      Discusses beta-alanine as having strong, well-supported effects for improving muscular endurance, anaerobic running capacity, reducing fatigue, and potentially reducing body fat and improving lean mass, with a standard dose of 2 to 5 grams.
  • Bryan Johnson · Niacin · recommends
    • Date not recorded · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • 5 Jun 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 12 May 2025 · Calcium · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
    • Date not recorded · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
    • Date not recorded · Calcium · recommends · Website ↗
      Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
    • Date not recorded · Calcium · uses · Website ↗
      Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
    • Date not recorded · Calcium · recommends · Source ↗
      Recommends continuing with calcium to support bone health during the follicular phase.

RAL Summary

Members OnlyTier 4 for Circulation

Tier 4 because the arginine, citrulline and niacin in this product are at trace or low doses compared with the amounts that helped in studies, and no reviews could be counted.

  • Emerging: not enough evidence to rank higher yet.
  • Niacin: trace amount
  • L-Arginine: trace amount
  • Citrulline: below the dose that worked in studies
  • L-Citrulline Malate: trace amount

Where the evidence disagrees: 47 of the 135 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system

Combine with: For the product's actual purpose of blood flow support, pair it with beetroot extract or nitrate sources, vitamin C, and CoQ10 for endothelial and mitochondrial support, magnesium for vascular relaxation, and omega-3 fish oil for cardiovascular health. For the regularity goal, choose a different product: magnesium citrate or oxide, psyllium husk or partially hydrolyzed guar gum for fiber, adequate water, probiotics such as Bifidobacterium lactis BB-12, and prunes or kiwifruit extract. Consult a healthcare provider before combining L-Arginine with blood pressure or erectile dysfunction medications.

Possible side effects: No major side effects reported for this product; in one small study of older adults, a few days of arginine worsened small blood vessel function in the fingers, and in pregnant women with preeclampsia citrulline was linked to higher blood pressure.

Supplement Facts

Calcium 30 mg · Niacin 30 mg NE · L-Arginine 400 mg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Calcium30 mg
Niacin30 mg NE
L-Arginine400 mg†
L-Arginine Alpha-Ketoglutarate400 mg†
L-Citrulline Hydrochloride200 mg†
L-Citrulline Malate200 mg†
Beta-Alanine80 mg†
† Daily Value not established.

Other ingredients: Cellulose, Magnesium Stearate, Silicon Dioxide.

Directions: Suggested use: As a dietary supplement, take two (2) capsules once a day. For best results take 20-30 min before a meal with an 8 oz. glass of water or as directed by your healthcare professional.

Label source: NIH label database · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.