INNOSUPPS Inno Shred™ GLP-1 3-Month Supply Review

Inno Shred™ GLP-1 is a stimulant-containing thermogenic and appetite-support dietary supplement from the US brand InnoSupps. The 3-Month Supply bundles three bottles. Each bottle holds 60 capsules, which is 30 servings at 2 capsules per serving, so the bundle covers about 90 days. The brand recommends roughly 90 days of consistent use. Retailer and aggregator listings give these per-serving amounts: - Berberine HCl: 200 mg - Caffeine: 250 mg - Chromium: 300 mcg - Grains of Paradise seed extract (Paradoxine®): 40 mg - Alpha-yohimbine: 2 mg - Niacin: 15 mg NE - Vitamin B6: 5 mg - Vitamin B12: 50 mcg Some listings also name astragalus and tienchi ginseng root extracts. Those listings give no amounts for them. The excipients are a hypromellose capsule, microcrystalline cellulose, magnesium stearate and silicon dioxide. **How it is meant to work** The product is not a med such as a med. It contains no peptide and does not bind the GLP-1 receptor directly. The "GLP-1" in the name refers to a claim that the ingredients support the body's own GLP-1 activity. - **Berberine:** This is the central ingredient. In lab and small clinical studies it activates AMPK, the cellular energy sensor. That improves insulin sensitivity and lowers glucose. It may also influence gut hormone secretion, including GLP-1, and the gut microbiome. This is the basis for the claims about appetite and cravings. - **Caffeine, Paradoxine and yohimbine:** Caffeine raises sympathetic nervous system activity, energy and perceived alertness. It also modestly raises energy expenditure. Grains of Paradise is marketed to stimulate brown adipose tissue and thermogenesis. Alpha-yohimbine blocks α2-adrenergic receptors, which is meant to promote fat mobilization. - **Chromium and niacin:** Chromium is a cofactor in insulin signaling and is used for glucose handling and carbohydrate cravings. Niacin and the B vitamins support energy metabolism. **Important caveats** The human evidence for berberine's effect on glucose is moderate. Evidence that this specific blend increases GLP-1 or causes meaningful fat loss is limited. I found no independent clinical trial of the finished product. The product is a daytime stimulant formula with about 250 mg of caffeine plus yohimbine. People who are sensitive to stimulants, have heart conditions or high blood pressure, are pregnant or nursing, or take meds, meds or meds should speak to a clinician first. Berberine can interact with many medications, and it commonly causes digestive upset. The product makes the usual unevaluated FDA supplement claims. It works best alongside diet and exercise, not as a replacement for them.

Product Focus: Weight and Metabolism for MenAlso covers:BrainHeartDigestion
Tier ⓘ
Tier 4 · Rank 11
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 11 within Tier 4 for Weight and Metabolism for Men; 19 of 23 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
33 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 6,352 reviews
Biohacker Mentions
9 of 10

Study, Trial or Testing Result Summary

Members Only192 human studies · 78 improved

1 of these 192 human studies gave the ingredient by drip, not by mouth.

192 human studies78 improved89 no effect70,486 people studied

Several main ingredients are at or above studied doses. Chromium lowered weight by only about 0.5 to 1.1 kilograms in pooled trials [1][2][3], and a high dose added no extra weight loss in 80 overweight adults [4]. Higher caffeine intake was linked to greater drops in weight and body fat across 13 trials [5], and caffeine before interval training helped 30 obese men lose more fat [6], though not every trial agreed [7]. Berberine at two servings a day lowered weight by about 0.9 to 2 kilograms in pooled trials [8][9], but a six month trial found no drop in belly or liver fat [10]. Grains of paradise at this dose raised energy use and slightly lowered body fat in young men [11][12], but a 2026 trial found no change in weight [13]. Yohimbine is below the studied dose, and a six month trial in men found no effect [14]. Tienchi ginseng is hidden in a blend and has only animal studies [15]. Niacin and vitamin B12 did not change weight in trials [16][17]. Animal and cell studies are never counted.

See all 192 studies →Hide the studies

Review Totals and Summary

Members Only6,352 reviews
6,352 reviews · Google 6,352

Buyers are very positive about Inno Supps, with many crediting it for real weight loss when combined with exercise and healthy eating. Note that most comments talk about the brand in general rather than this specific 3-month GLP-1 product, and none mention the product's taste, size, or price. **What buyers say it did for them:** The main theme is weight loss. Some give large figures: "I lost 65 pounds using Inno Supps products," and another reports losing "70lbs in 5 months." One buyer went from 265 to 200 pounds and from 40% to 20% body fat in a year, with gym visits and daily use. Another says they now lose "three pounds a week" instead of three a month. Others describe a boost to metabolism and digestion, better sleep, and better focus through the workday (the focus comment refers to a different product, Inno Drive: For Her). **What they complain about:** No reviews here express a complaint about the product itself. The closest thing to a caveat is one buyer who says it "was still a challenge" even with the supplements. Others stress that results came alongside healthy eating and exercise. These reviews also appear to be a curated set of testimonials, so the lack of criticism should be read with that in mind. **Taste, smell, pill size or form:** The reviews say nothing about this, so there is nothing to report on flavor, odor, capsule size, or how easy it is to take. One reviewer mentions taking a product "before work," and others say they use it every day, but no details on form are given. **Value for money:** Nobody comments on price or on whether the 3-month supply is worth the cost. The nearest remark is a buyer who saw ads on social media, took a chance, and found it "by far exceeded my expectations." That suggests satisfaction, but it is not a statement about value. **Who it seems to suit and who it did not:** It seems to suit people who are already working out and eating better and want extra support. One reviewer recommends it to anyone "struggling and in a rut" who feels they cannot lose weight. Another says they "would not be where I am" without it, alongside diet and exercise. One buyer picked a women's-targeted product for focus and workouts. No reviews describe anyone it did not suit, so the reviews cannot say who should avoid it. **Bottom line:** The feedback is enthusiastic and centers on weight loss and energy when paired with lifestyle changes. It is thin on specifics about this exact product, its form, and its cost, so check those details on the product page before buying.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Niacin is the main ingredient, and the panel leans positive: four of the ten recommend it, two use it, and four stay neutral. The most common reason is to raise NAD, a cellular energy molecule, with one panelist calling cheap flush niacin better than costly NAD supplements and another naming niacin as a key raw material for making NAD from foods like beef liver, fish or supplements. Several prefer niacinamide, a form of niacin, either to kick start the morning body clock or for skin health, and two mention it for skin, one by applying it to the skin. One panelist takes enough niacin to flush about half an hour before a sauna session, and another notes it may pair well with plant compounds that switch on the body's defenses to help with plaque in the arteries. No one gave a dose, and no one warned against it or said they stopped. Berberine and caffeine are smaller ingredients in this product, and panelists mostly speak of them as helpful for blood sugar or focus, with several advising to keep caffeine earlier in the day.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Niacin · recommends
    • 19 Oct 2026 · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 30 Oct 2026 · Berberine · recommends · YouTube ↗
      Recommends adding berberine as another natural remedy to the combination for cancer.
    • 25 Oct 2026 · Berberine · recommends · Instagram ↗
      Dr. Eric Berg states that Berberine combined with a lower-carb diet may help support healthy blood sugar levels and reduce cravings over time.
    • 20 Oct 2026 · Berberine · neutral · YouTube ↗
      Notes that some people add berberine, which supports healthy blood glucose and makes one insulin resistant.
    • 11 Oct 2026 · recommends · YouTube ↗
      Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
    • 10 Oct 2026 · Vitamin B6 · warns · Podcast ↗
      Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
    • 4 Oct 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
    • 4 Oct 2026 · Vitamin B6 · neutral · X ↗
      Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 4 Oct 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
    • 4 Oct 2026 · Vitamin B12 · neutral · X ↗
      Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 2 Oct 2026 · recommends · YouTube ↗
      States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
    • 27 Sep 2026 · neutral · X ↗
      Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
    • 25 Sep 2026 · Caffeine · warns · Podcast ↗
      Warns that caffeine can keep you awake and advises to watch out for hidden sources of caffeine.
    • 20 Sep 2026 · Berberine · recommends · Facebook ↗
      Recommends taking berberine to block the effects of grains.
  • Dr. Mark Hyman · Niacin · neutral
    • 30 Sep 2026 · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 7 Oct 2026 · Caffeine · warns · YouTube ↗
      Discusses with patients their caffeine consumption, suggesting that too much caffeine can artificially increase their stress response.
    • 17 Sep 2026 · Caffeine · recommends · X ↗
      Recommends stopping caffeine by noon.
    • 31 Aug 2026 · Caffeine · neutral · YouTube ↗
      States that caffeine's effect on ADHD depends on the person, as it can help focus but also activate irritation or stress, and its impact is related to individual caffeine metabolism.
    • 31 Aug 2026 · Vitamin B6 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 22 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 is a nutritional deficiency that impacts mental health.
    • 20 Jul 2026 · Caffeine · warns · YouTube ↗
      Warns that drinking coffee first thing in the morning before eating layers caffeine on top of already elevated stress hormones, providing unsustainable energy and setting up for an afternoon crash.
    • 20 Jul 2026 · Berberine · uses · X ↗
      Takes 500 mg of Berberine with meals for blood sugar control.
    • 29 Jun 2026 · Caffeine · neutral · Facebook ↗
      Notes that caffeine is one of the things that drives the hormone imbalance causing PMS.
    • 29 Jun 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
    • 29 Jun 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
    • 3 Jun 2026 · Vitamin B6 · neutral · YouTube ↗
      Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
    • 3 Jun 2026 · Vitamin B12 · recommends · YouTube ↗
      Mentions that repletion of vitamin B12 can help safely withdraw someone from meds and that simple vitamin B12 deficiencies are important to address in a depression workup.
    • 1 Jun 2026 · Caffeine · warns · YouTube ↗
      States that drinking coffee on an empty stomach, which is how most people do it, is probably not the best thing as it gives a jolt of caffeine and adrenaline before eating.
  • Thomas DeLauer · Niacin · uses
    • 5 Sep 2026 · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 29 Oct 2026 · Caffeine · neutral · YouTube ↗
      Explains that caffeine from green tea mobilizes fatty acids, which can be converted into ketones, providing a ketone boost, especially in a fasted or low-carb state.
    • 27 Oct 2026 · Caffeine · warns · YouTube ↗
      Warns that treating brain fog with caffeine without addressing underlying inflammation is ineffective and likely to make the situation worse.
    • 25 Oct 2026 · Berberine · neutral · YouTube ↗
      Mentions dihydroberberine as a component that can be used to optimize and support the AMPK pathway, helping to tune it up and have a higher baseline.
    • 24 Oct 2026 · Berberine · uses · YouTube ↗
      Has found berberine to be very helpful for some of his patients who are night snackers, especially those with a sweet tooth.
    • 21 Oct 2026 · Caffeine · uses · Facebook ↗
      Notes that caffeine significantly increased fat metabolism and fat oxidation during exercise, especially at lower intensities, and that adding coffee around an exercise bout led to more calories and fat burned.
    • 21 Oct 2026 · Caffeine · uses · Instagram ↗
      Says that caffeine significantly increased fat metabolism and that at low intensity cardio or exercise caffeine works better at mobilizing and utilizing fat.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 14 Oct 2026 · Caffeine · uses · YouTube ↗
      Might have some caffeine before fasted training.
    • 28 Sep 2026 · Berberine · recommends · YouTube ↗
      Recommends berberine if one is going to have fruit later in the day, as it specifically restores the AMPK-driven fat suppression.
    • 26 Sep 2026 · Caffeine · recommends · YouTube ↗
      Recommends caffeine as a must on the fasting day to create a low-grade energy demand that forces the body to favor lipolysis.
    • 26 Sep 2026 · Berberine · recommends · YouTube ↗
      Recommends Dihydroberberine to improve mitochondrial performance and turn up the AMPK dial.
    • 2 Sep 2026 · Caffeine · recommends · YouTube ↗
      Recommends drinking 150 to 200 mg of caffeine immediately before a 20-minute nap to enhance alertness and performance, as the caffeine peaks when the nap has cleared adenosine.
    • 1 Sep 2026 · Caffeine · recommends · Instagram ↗
      States that caffeine is probably the most studied ergogenic aid with a profound effect on fat mobilization, suggesting that simple is better.
  • Ben Greenfield · Niacin · neutral
    • 29 Aug 2026 · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 24 Oct 2026 · Caffeine · stopped · Facebook ↗
      Came off caffeine for a year after his separation.
    • 24 Oct 2026 · Caffeine · stopped · Podcast ↗
      Quit caffeine in the same year he quit testosterone replacement therapy and alcohol.
    • 22 Oct 2026 · Caffeine · uses · YouTube ↗
      Uses caffeine, such as coffee or green tea, in his morning fasted fat-burning session to slightly increase the oxidation of fats.
    • 17 Oct 2026 · Caffeine · warns · YouTube ↗
      Advises against relying on caffeine for morning energy, suggesting that natural sugar-based stimulants combined with hydration and meditation can provide sufficient wakefulness.
    • 15 Oct 2026 · Chromium · neutral · YouTube ↗
      Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
    • 27 Sep 2026 · Caffeine · recommends · Facebook ↗
      Recommends Caffeine, noting that it can improve focus, mood, and training, help control appetite, raise calories burned, and reduce fatigue.
    • 18 Sep 2026 · Caffeine · neutral · X ↗
      Notes that 3 mg/kg of caffeine increases fat oxidation by 31%, and 5 mg/kg increases it by 51% compared to a placebo.
    • 16 Sep 2026 · Caffeine · neutral · X ↗
      Caffeine on its own isn’t particularly impressive as an ergogenic aid, but when combined with taurine, there are significant increases in power production.
    • 14 Sep 2026 · Caffeine · neutral · X ↗
      Mentions that caffeine can help mitigate the negative effects of a caloric deficit on lean muscle mass and metabolism.
    • 11 Sep 2026 · Caffeine · neutral · X ↗
      Has talked before about caffeine as a supplement that seems to assist with sleep deprivation.
    • 5 Sep 2026 · Caffeine · warns · X ↗
      Warns that energy drinks can deliver large doses of caffeine quickly, which may overstimulate the heart and cause abnormal heart rhythms and electrocardiogram changes, especially in children.
    • 9 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 13 Jun 2026 · Berberine · recommends · YouTube ↗
      States that berberine is great for sleep, upregulating serotonin and dopamine, and that their bioavailable berberine product is taken by 75% of users for sleep, even though it was created for blood glucose management.
  • Dave Asprey · Niacin · recommends
    • 25 Jul 2026 · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 31 Oct 2026 · Caffeine · uses · YouTube ↗
      Loves coffee, has the caffeine molecule tattooed on his arm, drinks it every morning, and says it does amazing things for your brain and for how long you can live, but it can't clear most brain fog on its own.
    • 23 Oct 2026 · Caffeine · recommends · Instagram ↗
      Created Danger Coffee, a mineral-enriched, lab-tested, mold-free coffee that delivers rich flavor and clean caffeine without all the junk, and recommends it to others.
    • 22 Oct 2026 · Caffeine · recommends · YouTube ↗
      Dave Asprey's lab proved that caffeine is a flow hack and the only known substance to actually make you flow prone. Coffee will make you more flow prone.
    • 11 Oct 2026 · Caffeine · recommends · Podcast ↗
      Dave explains why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration.
    • 3 Oct 2026 · Caffeine · uses · YouTube ↗
      States that his entire career started on caffeine and he uses it every morning, but notes it's like a loan from your future self, leading to an afternoon crash.
    • 1 Oct 2026 · Caffeine · stopped · YouTube ↗
      Dave Asprey's company used caffeine, which is a safe ingredient, but they stopped using it because it doesn't provide the type of results and change in the skin that newer ingredients do.
    • 3 Sep 2026 · Caffeine · uses · YouTube ↗
      States that caffeine is one of his superpowers and increases the rate of ketone formation, which fuels neurons.
    • 1 Sep 2026 · Berberine · recommends · YouTube ↗
      Recommends berberine as a good alternative to a med for longevity, citing its similar pathway effects without the downsides and its positive impact on the microbiome.
    • 31 Aug 2026 · Caffeine · uses · Instagram ↗
      Once I’ve hydrated and taken my creatine, I reach for Danger Coffee for caffeine and essential minerals in one cup.
    • 29 Aug 2026 · Berberine · neutral · YouTube ↗
      Dave Asprey discusses berberine as a plant compound that genuinely lowers blood glucose, comparable to a med in some trials, but notes its poor absorption and lack of lifespan data, classifying it as a glucose drug, not a longevity drug.
    • 22 Aug 2026 · Caffeine · uses · YouTube ↗
      Uses caffeine, noting it blocks adenosine to increase norepinephrine and dopamine signaling, fueling the prefrontal cortex for focus. He mentions it got him through business school and is part of his longevity journey.
    • 13 Aug 2026 · Caffeine · warns · YouTube ↗
      Does not believe caffeine is a nootropic, considering it just a stimulant.
    • 1 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
  • Siim Land · Niacin · recommends
    • 15 Feb 2026 · recommends · TikTok ↗
      Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
    • 25 Oct 2026 · Caffeine · recommends · Instagram ↗
      Recommends stopping caffeine earlier to improve sleep.
    • 19 Oct 2026 · Caffeine · neutral · YouTube ↗
      Notes that polyphenolic compounds in coffee, both decaf and regular caffeinated, can influence cellular stress pathways and have been seen to increase autophagy activity in mice, with regular coffee appearing more potent due to caffeine's additional energetic stress.
    • 19 Oct 2026 · Berberine · recommends · YouTube ↗
      Recommends berberine as a herbal supplement that increases fat metabolism, lowers mTor and blood sugar, making it a good combination for increased autophagy, and notes that meta-analyses show it reduces blood sugar, promotes weight loss, and decreases cholesterol.
    • 12 Oct 2026 · Caffeine · recommends · Instagram ↗
      Recommends moving caffeine intake earlier in the day because having it too late can disrupt sleep, especially for slow metabolizers.
    • 12 Oct 2026 · Caffeine · warns · YouTube ↗
      Recommends not having caffeine after lunch, noting that 400 mg 4 hours before bed reduced deep sleep by approximately 30 minutes in a trial, although he personally has a fast caffeine metabolism.
    • 7 Oct 2026 · Berberine · recommends · Instagram ↗
      Recommends Berberine for blood sugar and cholesterol, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Berberine · neutral · X ↗
      Lists Berberine as one of 15 supplements backed by human studies.
    • 28 Sep 2026 · Caffeine · warns · YouTube ↗
      Warns that combining a large dose of glycine with caffeine can amplify negative experiences, as caffeine independently increases arousal and can cause restlessness, anxiety, and increased heart rate.
    • 28 Sep 2026 · Berberine · warns · YouTube ↗
      Advises caution when using berberine with glycine, as it is a glucose-lowering medication.
    • 25 Sep 2026 · Caffeine · recommends · YouTube ↗
      States that regular coffee promotes visceral fat loss, and going from low or zero intake to moderate intake increases fat loss due to caffeine and polyphenols.
    • 28 Aug 2026 · Berberine · warns · YouTube ↗
      Is skeptical about most supplements, including berberine, because he doesn't see any evidence to back up their claims, which are often based on personal testimonials.
    • 7 Aug 2026 · Berberine · neutral · YouTube ↗
      Mentions berberine as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 26 Jul 2026 · Chromium · recommends · X ↗
      Recommends chromium as a mineral that can lead to better body composition.
  • Peter Attia · Niacin · uses
    • 29 Jun 2025 · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 16 Aug 2026 · Caffeine · uses · YouTube ↗
      States that he needs two to three times the normal dose of any medication or drug to feel an effect, including caffeine, and can drink four cups of coffee without feeling anything.
    • 4 Jan 2026 · Caffeine · neutral · YouTube ↗
      Mentions data suggesting caffeine might be more helpful in the luteal phase to help with fatigue components.
    • 12 Dec 2025 · Caffeine · uses · YouTube ↗
      Uses caffeine in combination with Alpha GPC, MCT, and Theanine, often adding it to coffee for long periods of cognitive work.
    • 7 Dec 2025 · Caffeine · uses · YouTube ↗
      Finds Alpha GPC works well with caffeine, and he puts a product containing Alpha GPC, MCT, and caffeine into his coffee for long periods of cognitive work.
    • 4 May 2025 · Caffeine · neutral · YouTube ↗
      Mentions that experimenting with the timing of caffeine is a great idea for sleep.
    • 27 Mar 2025 · Caffeine · warns · YouTube ↗
      Warns that decaffeinated coffee can contain significant amounts of caffeine and advises cutting off all coffee, including decaf, by 11 a.m. for better sleep quality.
    • 23 Mar 2025 · Caffeine · warns · YouTube ↗
      Explains that caffeine is problematic because it blocks adenosine receptors, leading to a 'caffeine crash' when it wears off and adenosine floods the receptors, causing sleepiness.
    • 10 Dec 2024 · Caffeine · neutral · YouTube ↗
      States that caffeine does not wake him up, which contributed to his belief that he did not have an addiction gene.
    • 14 Oct 2024 · Caffeine · neutral · YouTube ↗
      States that caffeine does not wake him up.
    • 10 Oct 2024 · Caffeine · warns · YouTube ↗
      Warns that constantly consuming caffeine and Red Bull to turn up the sympathetic dial is a sign that the sympathetic system isn't working as it should, possibly due to overstimulation from stress.
    • 9 Sep 2024 · Vitamin B12 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 3 Mar 2024 · Yohimbine · neutral · YouTube ↗
      Discusses yohimbine as an alpha-2 adrenergic antagonist that raises adrenaline signaling, which some people enjoy for an uptick in energy during training, and notes its use as an aphrodisiac, but reserves its recommendation for specific use cases in a deficit after other options have been tried.
    • 26 Feb 2024 · Yohimbine · neutral · YouTube ↗
      Discusses yohimbine as an alpha 2 adrenergic antagonist that raises adrenaline signaling, which some people enjoy for an uptick in energy during training, but notes it can feel racy and aggressive.
  • Andrew Huberman · Niacin · neutral
    • 1 Jul 2024 · neutral · Instagram ↗
      Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
    • 26 Oct 2026 · Caffeine · uses · YouTube ↗
      Used caffeine, taking 400 milligrams, to improve his mood and physical vigor during mundane tasks like swimming, noting that it made life not so bad and allowed him to rip through the water.
    • 26 Oct 2026 · Caffeine · neutral · Podcast ↗
      Mentions caffeine in a discussion about supplement use.
    • 22 Oct 2026 · Caffeine · neutral · Podcast ↗
      Discusses caffeine timing as a tool related to sleep.
    • 22 Oct 2026 · Caffeine · warns · YouTube ↗
      He recommends caffeine, in coffee or tea form, or in tablet or capsule form at lower dosages than found in coffee and tea, as a reasonable way to explore stimulant-based approaches for enhancing cognitive function and focus.
    • 22 Oct 2026 · Yohimbine · warns · YouTube ↗
      He describes yohimbine, particularly alpha-yohimbine (rauwolscine), as a potent and somewhat precarious stimulant that can promote fat loss and alertness, but warns that some people experience a lot of anxiety on it.
    • 1 Oct 2026 · Caffeine · recommends · YouTube ↗
      Huberman states that caffeine can improve focus and concentration, with a general useful range of 100 to 400 milligrams, and most people do well with 100 to 200 milligrams prior to focused work.
    • 1 Oct 2026 · Caffeine · neutral · Podcast ↗
      Discusses caffeine as a tool for improving attention, noting its impact on focus and sleep.
    • 28 Sep 2026 · Caffeine · uses · YouTube ↗
      Mentions that coffee and tea produce caffeine, which were likely defense chemicals, and that plants learned it was better to alter consciousness than kill predators outright.
    • 28 Sep 2026 · Caffeine · uses · Podcast ↗
      Discusses caffeine and its health benefits.
    • 6 Aug 2026 · Caffeine · recommends · Podcast ↗
      Recommends caffeine as a tool to increase motivation and dopamine.
    • 6 Aug 2026 · Caffeine · uses · YouTube ↗
      Huberman explains that regular ingestion of caffeine at safe levels of about 100 to 250 mg increases the number of D2 and D3 dopamine receptors, making circulating dopamine more potent.
    • 13 Jul 2026 · Berberine · uses · X ↗
      Takes 500 mg of berberine with meals to help with blood glucose.
    • 2 Jul 2026 · Berberine · stopped · YouTube ↗
      Dr. Huberman states he will skip berberine because it gives him brutal headaches, makes him crave carbohydrates, and drops his blood sugar.
  • Dr. Rhonda Patrick · Niacin · neutral
    • 28 Jan 2020 · neutral · YouTube ↗
      States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
    • 26 Oct 2026 · Caffeine · neutral · Instagram ↗
      Explains that caffeine can activate AMPK, a cellular energy sensor involved in fat burning and glucose regulation, which helps muscle cells take up glucose and promotes using fatty acids for energy.
    • 18 Oct 2026 · Berberine · neutral · Instagram ↗
      Notes that berberine is a promising compound for cardiovascular health, with potential benefits spanning lipid metabolism, artery health, and the gut microbiome.
    • 18 Oct 2026 · Berberine · neutral · X ↗
      Notes that berberine lowers LDL cholesterol in randomized trials and is interested in its connection to ApoB, artery plaque, and the gut microbiome.
    • 2 Oct 2026 · Caffeine · recommends · YouTube ↗
      Recommends pairing caffeine with L-theanine to enhance alertness and focus while mitigating anxiety and jitteriness, suggesting a dose of 100 to 150 mg of caffeine.
    • 30 Sep 2026 · Caffeine · recommends · Facebook ↗
      Recommends pairing coffee with L-theanine to enhance cognitive performance, noting that L-theanine can help balance caffeine’s stimulatory effects.
    • 28 Sep 2026 · Caffeine · warns · YouTube ↗
      Recommends cutting out caffeine in the three months before conception for both men and women, as it affects sperm.
    • 19 Aug 2026 · Berberine · neutral · X ↗
      Notes that berberine has been on their radar for glucose control for years, and a new study on a biooptimized form of berberine showed reductions in fasting glucose, improved glucose tolerance, and an increase in fasting.
    • 14 Aug 2026 · Caffeine · recommends · Facebook ↗
      Recommends caffeine for alertness and focus, especially when combined with L-theanine to smooth out the response and maintain cognitive benefits, suggesting a practical dose of 100-150 mg.
    • 5 Jun 2026 · Caffeine · recommends · Instagram ↗
      Recommends cutting down or eliminating caffeine when actively trying to conceive.
    • 27 May 2026 · Caffeine · warns · Facebook ↗
      Warns that a very high dose of caffeine, around 350 mg pre-workout, may blunt some of creatine's performance benefit due to opposite effects on muscle relaxation.
    • 1 May 2026 · Berberine · recommends · Facebook ↗
      Recommends berberine for atherosclerosis, noting it has a more compelling evidence base, showing reduction in plaque formation and improvement in LDL, HbA1c, and glucose regulation.
    • 24 Mar 2026 · Caffeine · uses · YouTube ↗
      Self-administers 350 mg of caffeine in a bolus right after returning from mass and his workout, and before eating, noting that he likes dark roast Starbucks.
    • 6 Feb 2026 · Caffeine · neutral · Instagram ↗
      The newest literature on Caffeine dose and its link to multiple cardiometabolic disease risk reduction shows that even the ≥400 mg group was healthier than 0 mg.
  • Bryan Johnson · Niacin · recommends
    • Date not recorded · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • 23 Sep 2026 · Caffeine · uses · YouTube ↗
      Drinks coffee when starting to fade, ensuring the last cup is between 10 and 12 hours before bed so caffeine doesn't affect sleep.
    • 18 Jun 2026 · Caffeine · uses · X ↗
      Used 300 mg of caffeine in the morning as part of their jet lag recovery.
    • 7 Jun 2026 · Caffeine · uses · X ↗
      Uses 300 mg of slow release caffeine in the morning as part of a jet lag recovery protocol.
    • 25 Apr 2026 · Caffeine · neutral · X ↗
      Notes that coffee affects the gut, which then affects the brain, and that it is the coffee bean, not the caffeine, doing most of the work.
    • 19 Nov 2025 · Caffeine · warns · YouTube ↗
      Notes that the culture in DC involves running on caffeine, along with alcohol and sleep deprivation, leading to poor nutrition and an unhealthy environment.
    • 3 Jul 2025 · Caffeine · warns · YouTube ↗
      Warns that caffeine has a 6-hour half-life, so consuming it later in the day will leave a significant amount in the body at bedtime, recommending consumption earlier in the day.
    • 5 Jun 2025 · Vitamin B12 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
    • 12 Apr 2025 · Caffeine · recommends · YouTube ↗
      Recommends consuming no caffeine past noon due to its 6-hour half-life, suggesting that if sleep is nailed, caffeine might not be needed.
    • 6 Nov 2024 · Caffeine · warns · YouTube ↗
      Warns against stimulants like caffeine for sleep, advising to have the last cup of coffee before noon if going to bed at 10:00 p.m.
    • 16 Oct 2024 · Caffeine · stopped · YouTube ↗
      Advises that if one is going to drink caffeine, they should try to have it earlier in the day and experiment to find the right time that doesn't disrupt their sleep.
    • 23 Mar 2024 · Caffeine · stopped · YouTube ↗
      Has stopped all caffeine, as it has helped him improve his sleep.
    • Date not recorded · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.

RAL Summary

Members OnlyTier 4 for Weight and Metabolism for Men

The review summary describes curated brand testimonials, including one about a different product (Inno Drive: For Her), not this specific product. The tier note also wrongly credits niacin, which its own studies show does not help weight. Its reviews are set aside, so it is graded on its studies alone. Human studies support Niacin (3 of 18 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).

Take 2 servings a day (4 capsules) to match the dose that worked in the studies.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 89 of the 192 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Metabolic system, Nervous system, Cardiovascular system, Digestive system

Combine with: For its intended weight management purpose, this product may pair well with fiber such as psyllium or glucomannan for satiety, berberine or chromium for blood sugar support, protein powder to preserve lean muscle during fat loss, and electrolytes plus plenty of water. For occasional heartburn, use a separate product such as calcium carbonate antacid chews, a sodium alginate formula (like Gaviscon-type), or magnesium hydroxide for fast relief, and consider DGL licorice or zinc-carnosine for longer-term mucosal support. Check with a healthcare provider if heartburn is frequent, and be cautious combining stimulant-containing fat burners with reflux-prone digestion.

Possible side effects: In studies, coffee raised blood pressure, heart rate and insomnia scores, and a high niacin dose reduced insulin sensitivity. No written reviews could be read.

Supplement Facts

Niacin 15 mg NE · Vitamin B6 5 mg · Vitamin B12 50 mcg
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30
Amount Per Serving% Daily Value
Niacin15 mg NE
Vitamin B65 mg
Vitamin B1250 mcg
Chromium300 mcg
Tienchi Ginseng root extract & Astragalus root extract (Innoslim™)250 mg†
Caffeine250 mg†
Berberine Hydrochloride200 mg†
Theobromine100 mg†
Grains of Paradise seed extract (Paradoxine®)40 mg†
Alpha yohimbine2 mg†
† Daily Value not established.

Other ingredients: Hypromellose Cellulose capsule, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide.

Directions: As a dietary supplement, take 1 serving (2 capsules) 1 to 2 times daily. For best results, take 30-60 minutes before meals or your workout. DO NOT EXCEED RECOMMENDED DOSAGE.

Label source: Reverseagelab · Report a label change

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Our articles on this subject

Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.