JayLab Pro Active Core Complex Review

Tier ⓘ
Tier 4 · Rank 7
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 7 within Tier 4 for Younger-Looking Skin for Women; 43 of 50 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only71 human studies · 57 improved

6 of these 71 human studies gave the ingredient by injection, not by mouth.

71 human studies57 improved7 no effect8,761 people studied

This is a pill taken by mouth, but nearly all the skin research behind its ingredients tested creams or injections. Vitamin A creams such as retinol clearly improved fine wrinkles and uneven color in sun-aged skin [1][2][3]. Vitamin A taken by mouth, as beta-carotene for about four and a half years, did not slow skin aging. Vitamin C creams and serums made skin smoother and less wrinkled [4][5]. Here vitamin C is only 12 milligrams by mouth, and 500 milligrams by mouth did not improve skin moisture or firmness. The calcium evidence comes only from calcium fillers injected into the skin, not from calcium taken by mouth [6][7]. No study looked at vitamin D for wrinkles, firmness or moisture; the only study was on eczema [8]. The iron studies used creams and makeup and did not measure skin aging [9][10]. The three blends, at 9 to 11 milligrams each, do not list their contents and have no human studies. No reviews have been counted yet. Animal and cell studies are never counted.

See all 71 studies →Hide the studies

Review Totals and Summary

Members OnlyWhat buyers say

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Vitamin D is the main ingredient and the panel backs it clearly: all ten spoke about it, and most recommend it or take it themselves. Three of them take 5000 units of the D3 form in the morning for general health, and one says to take it with dietary fat for better absorption, while others get it from salmon or sardines. They give reasons such as bone and muscle support, brain health, immunity and fixing low levels, and a few aim for blood levels in the range of 40 to 80, though one notes there is little point supplementing unless you are low. Vitamin C is also a main ingredient, and several recommend it, often paired with collagen before a workout, for skin, joints and immune support, with one noting a doctor once warned him off it. Iron is a smaller ingredient in this product, and one panelist said he stopped because no form of it raised his low levels for years.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Facebook ↗
      Lists Vitamin D as an ingredient found in sardines.
    • 8 Nov 2026 · Calcium · neutral · Facebook ↗
      States that one can of sardines contains 382 mg of calcium.
    • 8 Nov 2026 · Vitamin A · neutral · Facebook ↗
      Mentions that the body relies on healthy fats to absorb essential vitamins like A, D, E, and K, which help support skin health, moisture, and normal cell function.
    • 7 Nov 2026 · recommends · Facebook ↗
      Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
    • 7 Nov 2026 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Calcium · warns · Facebook ↗
      Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
    • 7 Nov 2026 · Vitamin A · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
    • 7 Nov 2026 · Vitamin C · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
    • 7 Nov 2026 · Iron · warns · Facebook ↗
      Warns against iron supplements, suggesting instead to get iron from red meat or liver.
    • 7 Nov 2026 · Iron · neutral · Instagram ↗
      Dr. Berg states that when nutrients like iron are too low, fatigue and weakness can follow.
    • 6 Nov 2026 · recommends · Podcast ↗
      Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
    • 6 Nov 2026 · recommends · YouTube ↗
      Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
    • 6 Nov 2026 · Calcium · recommends · Podcast ↗
      Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
    • 6 Nov 2026 · Vitamin C · neutral · Instagram ↗
      Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Instagram ↗
      Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
    • 4 Nov 2026 · neutral · Instagram ↗
      States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
    • 28 Oct 2026 · recommends · YouTube ↗
      Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin A · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 5 Jun 2026 · Vitamin C · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
  • Thomas DeLauer · Vitamin C · recommends
    • 6 Nov 2026 · recommends · YouTube ↗
      Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
    • 5 Nov 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
    • 2 Nov 2026 · Iron · recommends · YouTube ↗
      Recommends giving any iron intervention a couple of months before deciding if it works, and suggests increasing heme iron through red meat or liver intake.
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 29 Sep 2026 · Vitamin D · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
  • Dr. Mark Hyman · Vitamin D · uses
    • 4 Nov 2026 · uses · YouTube ↗
      Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
    • 29 Oct 2026 · Iron · neutral · YouTube ↗
      States that iron helps red blood cells carry oxygen, and a deficiency can make one feel like they are running on low power mode.
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Iron · neutral · YouTube ↗
      Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
  • Dave Asprey · Vitamin C · neutral
    • 3 Nov 2026 · neutral · YouTube ↗
      Recounts a doctor telling him in his 20s that vitamin C would kill him.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 24 Oct 2026 · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 5 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · Vitamin D · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 3 Sep 2026 · Vitamin A · recommends · YouTube ↗
      Recommends real vitamin A for people on the spectrum, noting that many cannot convert plant vitamin A and need the good stuff he includes in his Vitam DAKNE product.
    • 29 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 18 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D as one of the most important supplements for overall health.
    • 14 Aug 2026 · neutral · Podcast ↗
      Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
    • 12 Aug 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 14 Oct 2026 · Iron · neutral · Instagram ↗
      Mentions that iron is a mineral necessary for making collagen.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 30 Sep 2026 · Vitamin A · neutral · X ↗
      Lists liver and carrots as sources of Vitamin A.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 6 Sep 2026 · Vitamin C · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 3 Sep 2026 · Iron · warns · YouTube ↗
      States that excess iron promotes oxidative stress and inflammation, which increases heart disease risk.
    • 26 Aug 2026 · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
  • Ben Greenfield · Vitamin C · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 24 Sep 2026 · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 25 Aug 2026 · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 20 Aug 2026 · Vitamin D · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 8 Aug 2026 · Vitamin D · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
    • 8 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
    • 18 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting enough vitamin D for blood pressure management.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends Vitamin C for skin repair post-tattoo.
    • 9 Jul 2026 · Vitamin D · recommends · YouTube ↗
      Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 8 Jul 2026 · Iron · stopped · YouTube ↗
      Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
    • 7 Jul 2026 · Iron · uses · X ↗
      Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 5 Jun 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 12 May 2025 · Calcium · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
  • Andrew Huberman · Vitamin D · neutral
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 20 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 20 Jul 2026 · Iron · recommends · YouTube ↗
      States that Iron is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 12 Jul 2026 · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 6 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 22 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 17 Jun 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
    • 17 Jun 2026 · Vitamin C · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 17 Jun 2026 · Vitamin A · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 6 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 2 Feb 2026 · Vitamin C · recommends · YouTube ↗
      Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
  • Peter Attia · Vitamin D · uses
    • 4 Jan 2026 · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 20 Jul 2025 · Vitamin A · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
    • 10 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 3 Jul 2025 · Vitamin C · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · Vitamin C · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.

RAL Summary

Members OnlyTier 4 for Younger-Looking Skin for Women

Emerging because the strong vitamin A, vitamin C and calcium results come from creams and injections rather than a pill, and oral vitamin A and C did not help skin. There are also no reviews yet.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 7 of the 71 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Skin

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: Studies of stronger retinol creams reported dryness, scaling and stinging, but these were skin-applied products, not this pill. No reviews have been read.

Supplement Facts

Vitamin A 1200 mcg RAE · Vitamin C 12 mg · Vitamin D 1.2 mcg
Supplement Facts
Serving Size 2 Vegetable Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Vitamin A1,200 mcg RAE
Vitamin C12 mg
Vitamin D1.2 mcg
Calcium40 mg
Iron0.7 mg
Traditional Wellness Support Blend11 mg†
Green Leaf Blend10 mg†
Cellular and Skin Protection Blend9 mg†
† Daily Value not established.

Other ingredients: Vegetarian Capsule, Cellulose, Plant, Magnesium Stearate, Silica.

Directions: Suggested Use: Take two capsules daily, with or without food.

Barcode (UPC) 854389007187 · Label source: NIH label database · Report a label change

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Our articles on this subject

Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.