JayLab Pro Active Core Complex Review
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Study, Trial or Testing Result Summary
Members Only71 human studies · 57 improved
6 of these 71 human studies gave the ingredient by injection, not by mouth.
This is a pill taken by mouth, but nearly all the skin research behind its ingredients tested creams or injections. Vitamin A creams such as retinol clearly improved fine wrinkles and uneven color in sun-aged skin [1][2][3]. Vitamin A taken by mouth, as beta-carotene for about four and a half years, did not slow skin aging. Vitamin C creams and serums made skin smoother and less wrinkled [4][5]. Here vitamin C is only 12 milligrams by mouth, and 500 milligrams by mouth did not improve skin moisture or firmness. The calcium evidence comes only from calcium fillers injected into the skin, not from calcium taken by mouth [6][7]. No study looked at vitamin D for wrinkles, firmness or moisture; the only study was on eczema [8]. The iron studies used creams and makeup and did not measure skin aging [9][10]. The three blends, at 9 to 11 milligrams each, do not list their contents and have no human studies. No reviews have been counted yet. Animal and cell studies are never counted.
See all 71 studies →Hide the studies
- Across 23 trials with 3905 people, creams with vitamin A-type compounds (a med, retinol, tretinoin) significantly improved fine wrinkles and tretinoin and retinol improved pigmentation in sun-aged facial skin.Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis.
- Across eleven randomized trials with 686 children and adults with atopic dermatitis, vitamin D supplements reduced eczema severity more than control, but the study did not measure wrinkles, elasticity or skin hydration.Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
- Pooling seven studies, beta-carotene (a plant form of vitamin A) taken for at least 10 weeks protected against sunburn, with more protection the longer it was taken.Protection from sunburn with beta-Carotene--a meta-analysis.
- In a review of 30 trials for sun-damaged skin, one small study showed benefit from vitamin C applied to skin compared with placebo, while tretinoin had the strongest evidence.Interventions for photodamaged skin.
- A review of 32 studies with 1236 people on anti-aging skin products gave retinol (vitamin A) its top recommendation grade for anti-aging, with few significant side effects.Cosmeceuticals for antiaging: a systematic review of safety and efficacy.
- A review of seven trials with 139 volunteers found skin treated with vitamin C looked smoother, less wrinkled and lighter, but hydration improved as much with placebo.Efficacy of topical vitamin C in melasma and photoaging: A systematic review.
- In 25 studies comparing other creams with tretinoin (a vitamin A drug), the others worked better in 7, equally in 13 and worse in 3, and most were gentler on skin, though study quality was mostly poor.Comparing Tretinoin to Other Topical Therapies in the Treatment of Skin Photoaging: A Systematic Review.
- A review of seven studies found that all used vitamin C with other ingredients or treatments, so its own effect on wrinkles could not be clearly determined.Clinical Efficacy of Topical Vitamin C on the Appearance of Wrinkles: A Systematic Literature Review.
- A review found injected calcium hydroxylapatite filler to be safe and effective for cheeks, jawline and nasolabial folds, though no randomized trials existed for diluted forms.A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for tre…
- A review found diluted injected calcium hydroxylapatite gave a skin-tightening effect on body areas with a good safety profile, but randomized trials were lacking.A systematic review of Radiesse® (calcium hydroxylapatite): evidence and recommendations for the body.
- A review of 45 articles on injectable skin biostimulators, including calcium hydroxylapatite, found they may mitigate facial aging, but quantifiable data are limited and more controlled studies are needed.The emerging role of biostimulators as an adjunct in facial rejuvenation: A systematic review.
- A review of 29 small, varied studies found injected calcium hydroxylapatite combined with ultrasound, laser or microneedling improved skin texture and elasticity, though side effects occurred in 15-30% of cases.A Systematic Review on the Effectiveness and Safety of Combining Biostimulators with Botulinum Toxin, Dermal Fillers, an…
- A review found combined hyaluronic acid and calcium hydroxylapatite treatments gave high aesthetic effectiveness and satisfaction for facial rejuvenation, with a slight decline after six months.Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechan…
- A review of 14 studies found injected calcium hydroxyapatite (and poly-L-lactic acid) improved facial skin elasticity and reduced wrinkles, with results lasting 12 to 18 months for calcium hydroxyapatite.Efficacy, Durability, and Safety of Collagen Biostimulators Based on Poly-L-Lactic Acid (PLLA) and Calcium Hydroxyapatit…
- In 903 adults under 55 given 30 mg of beta-carotene or placebo daily for about 4.5 years, beta-carotene had no overall effect on skin aging.Sunscreen and prevention of skin aging: a randomized trial.
- In 120 women with sun-aged skin, a nightly retinol 0.2% cream used for 3 months improved wrinkles, pigmentation and pores about as much as tretinoin 0.025% cream and was better tolerated.A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin.
- In 117 people with moderate to deep nasolabial folds, 79% had better improvement on the side injected with calcium hydroxylapatite than the side with human collagen over 6 months.A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for …
- In 87 women, a cream containing retinol reduced the appearance of wrinkles more than placebo, by 23.5% after 4 weeks and 27.8% after 8 weeks.The skin aging index: a new approach for documenting anti-aging products or procedures.
- In 87 women aged 40-65 taking collagen with 80 mg vitamin C daily for 16 weeks, skin density, texture and wrinkles improved, but elasticity and hydration did not change significantly.The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin De…
- In 72 women aged 35 or older, a daily collagen and vitamin C drink for 12 weeks improved skin hydration, elasticity, roughness and density more than placebo.A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Cont…
- In 69 women using a vitamin C derivative cream twice daily for 8 weeks on one side of the face, wrinkles around the eyes improved compared with placebo cream on the other side.Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
- In 64 patients after laser treatment for acne scars, an antioxidant serum with vitamin C used for 14 days improved healing and skin hydration compared with saline on the other side of the face.Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fract…
- In 60 women aged 20-50 with facial melasma, a multi-ingredient serum containing a small amount of vitamin C used for 5 months reduced pigmentation about as much as 4% hydroquinone, with better hydration, skin barrier function and tolerance in the serum group.Evaluation of the Efficacy of a Serum Containing Niacinamide, Tranexamic Acid, Vitamin C, and Hydroxy Acid Compared to 4…
- In 50 women aged 30-65, a serum with vitamin C, vitamin E and raspberry leaf extract applied to one side of the face for 8 weeks improved skin color, elasticity, radiance, smoothness, scaliness and wrinkles compared with the untreated side.Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell cultu…
- In 50 healthy adults, 12 weeks of green tea catechins plus vitamin C twice daily protected only one skin elastic fiber protein (fibulin-5) from sun-simulating light damage, with no difference from placebo for other collagen and elastic components.Ultraviolet radiation-induced degradation of dermal extracellular matrix and protection by green tea catechins: a random…
- In 44 people using 0.5% retinol cream daily on the face for 12 weeks, wrinkle surface area and dark spots decreased, similar to bakuchiol, but retinol caused more scaling and stinging.Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing.
- In 40 women with sun-aged skin, a retinol, lactose and glycolic acid cream applied twice daily for 12 weeks improved skin appearance, surface texture and moisture compared with a placebo cream on the other side of the face.Combined retinol-lactose-glycolic acid effects on photoaged skin: a double-blind placebo-controlled study.
- In 36 elderly people (average age 87), 0.4% retinol lotion applied up to 3 times a week for 24 weeks reduced fine wrinkling much more than the vehicle lotion on the other arm and increased skin collagen and water-holding molecules.Improvement of naturally aged skin with vitamin A (retinol).
- In 32 healthy volunteers, 500 mg daily vitamin C for 12 weeks did not improve skin hydration or elasticity beyond baseline, and adding it to collagen peptides did not enhance the collagen effect.Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study.
- In 31 adults aged 30 to 65, applying a vitamin C, E and ferulic acid serum daily for 12 weeks after microneedle treatment reduced neck wrinkles more (29.9% vs 18.0%) and improved elasticity (12.9% vs 2.3%) compared with placebo on the other side of the neck.Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuven…
- In 24 Korean women, a vitamin C microneedle patch applied twice daily for 12 weeks produced significant reductions in crow's feet wrinkle roughness, with no side effects reported.Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles.
- In 24 women aged 35-45, calcium hydroxylapatite filler injected on one side produced more collagen and elastin than a hyaluronic acid filler on the other side over 9 months, with less inflammation.A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-ba…
- In 23 Korean volunteers, a retinaldehyde cream applied for 8 weeks improved wrinkle depth, skin firmness and hydration, and did somewhat better than a retinol cream on the other side of the face.The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face cont…
- In 22 people, calcium hydroxyapatite injected into the hands improved skin hydration, thickness and appearance over 90 days, with no difference between dilution types.Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind Clini…
- In 21 people given facial injections near the nasolabial fold for 13 weeks, calcium hydroxylapatite showed no evidence of tissue regeneration and turned on more inflammation-related genes than poly-L-lactic acid.Gene Analysis of Biostimulators: Poly-L-Lactic Acid Triggers Regeneration While Calcium Hydroxylapatite Induces Inflamma…
- In women, 0.25% retinol applied after a salicylic acid peel for 4 weeks improved sun damage signs compared with baseline, though tretinoin was slightly better.Combination Superficial Peels With Salicylic Acid and Post-Peel Retinoids.
- In women with facial sun damage, a 1.1% retinol ester cream for 24 weeks did not differ significantly from 0.02% tretinoin in photoaging scores, though it caused redness less often.Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Rand…
- In a randomized, double-blind study of 19 adults with sun-damaged facial skin, applying a vitamin C serum daily for 3 months improved skin texture and wrinkling more than the vehicle serum on the other side of the face, as shown by skin surface measurements and clinical grading.Use of topical ascorbic acid and its effects on photodamaged skin topography.
- In 16 adults, a 0.1% retinol forearm cream for 3 weeks significantly increased most skin aging biomarkers measured.Climbazole boosts activity of retinoids in skin.
- In women with cellulite, topical retinol for 6 months increased skin elasticity by 10.7% compared with placebo on the other side, though the lumpy appearance changed little.A randomized, placebo-controlled trial of topical retinol in the treatment of cellulite.
- In 15 women aged 19-40 exposed to air pollution particles for 4 days, a vitamin C, ferulic acid and vitamin E serum applied to the back protected collagen and elastin and reduced markers of inflammation and oxidative stress in skin biopsies.Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.
- After a botulinum toxin injection, a retinol, adenosine and hyaluronic acid skincare routine used for 2 months gave extra benefit over placebo for fine lines, wrinkles and smoothness of the face.A skincare containing retinol adenosine and hyaluronic acid optimises the benefits from a type A botulinum toxin injecti…
- In a double-blind trial of women with sun-aged skin, a 5% vitamin C cream applied daily for 6 months improved overall skin appearance and surface texture compared with the vehicle cream and was well tolerated.Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. …
- In women with decollete wrinkles treated with diluted calcium hydroxylapatite injections over up to 52 weeks, 73.5% improved by at least one grade on a wrinkle scale 16 weeks after the last treatment, with a favorable safety profile.A Prospective, Multicenter, Evaluator-Blinded, Randomized Study of Diluted Calcium Hydroxylapatite to Treat Decollete Wr…
- In people with darker skin (Fitzpatrick type IV), foundations containing iron oxide protected against visible light-induced skin darkening better than untreated skin or mineral sunscreen, but wrinkles, elasticity and hydration were not measured.Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individual…
- In 57 volunteers using creams twice daily for 56 days, milk thistle extract reduced wrinkles similarly to retinol and better than bakuchiol, while 43% reported discomfort with retinol versus 0% with the extract.Silybum marianum Extract: A Highly Effective Natural Alternative to Retinoids to Prevent Skin Aging Without Side Effects…
- In 37 volunteers using retinol serum once daily for 12 weeks (0.3% on one side of the face, 0.5% on the other), dark spots, uneven skin and wrinkles decreased gradually, with more skin irritation on the 0.5% side.A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial.
- In 33 women, a cream with 3% vitamin C applied daily to the forearm for four months increased the density of dermal papillae, the small skin structures that carry capillaries, from 4 weeks onward compared with the cream base alone.Topically applied vitamin C increases the density of dermal papillae in aged human skin.
- In a split-face trial of 31 Chinese women, 0.03% hydroxypinacolone 9-cis retinoate applied daily for 4 weeks improved wrinkles, elasticity, and hydration as well as or better than 0.3% retinol, without irritation.Hydroxypinacolone 9-cis retinoate mitigates UV-induced photoaging by modulating extracellular matrix, fibroblasts, infla…
- In 30 Japanese women with crow's feet wrinkles, a retinol lotion applied to one side of the face for 8 weeks produced marked or moderate improvement in 34% of subjects, with wrinkle length and area reduced more than on the untreated control side, and no significant side effects.Evaluation of anti-wrinkle effects of a novel cosmetic containing retinol using the guideline of the Japan Cosmetic Indu…
- In a half-face study of 27 Japanese women with dark sun spots, a vitamin C derivative lotion applied twice daily for 24 weeks gave a weak lightening effect on the spots, but pigmentation scores did not differ from the placebo lotion.Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.
- In placebo-controlled tests including 25 volunteers for one month and a 12-week usage study, a face cream with 3% vitamin C lowered skin oxidative stress, increased the number of dermal papillae, and significantly reduced facial wrinkles.Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy.
- In a split-face trial of 24 adults with sun-damaged skin, using a handheld device to push vitamin C into the skin twice a week for 8 weeks improved pore tightening and skin hydration on the treated side compared with baseline, with no adverse reactions recorded.Efficacy of handheld iontophoresis device in enhancing transdermal vitamin C delivery: A split-face clinical trial.
- In 18 people allergic to hexavalent chromium, creams containing iron sulfate or glutathione reduced allergic skin reactions on the back, but wrinkles, elasticity and hydration were not measured.Skin application of glutathione and iron sulfate can inhibit elicitation of allergic contact dermatitis from hexavalent …
- In 11 Korean women over 30 with eye-area wrinkles, a 0.06% retinyl retinoate cream applied for 12 weeks reduced wrinkle depth and area, performing about 22% better than a 0.075% retinol cream.Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled tri…
- A hydrogel carrying ascorbyl palmitate, a vitamin C form, moisturized skin better than a placebo gel in both short-term and long-term tests.Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nan…
- Creams containing 1% of a fat-soluble vitamin C derivative increased skin moisture and improved skin smoothness in volunteers over 15 days of use.Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: stability studies and in vivo efficacy.
- In 44 women with mild to moderate hyperpigmentation and photodamage, a 0.5% retinol treatment plus a vitamin C moisturizer used for 12 weeks significantly improved all clinically graded signs at weeks 8 and 12, with dryness rising early and resolving by week 12.An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women W…
- In 35 women aged 35 to 65 with mild to moderate facial aging, twice-daily use of a multi-ingredient skincare regimen containing retinol for 12 weeks improved skin smoothness, dryness, fine lines and firmness compared with their starting point, though there was no control group.Novel Facial Treatment Regimen Improves Aging Skin Appearance.
- In 31 women aged 43 to 65 without a control group, a vitamin C, vitamin E and green tea serum applied twice daily for 12 weeks improved wrinkles, smoothness, radiance and skin density.Novel Vitamin C and E and Green Tea Polyphenols Combination Serum Improves Photoaged Facial Skin.
- In 23 adults aged 45 to 68 using a topical cosmetic retinol product for 12 weeks without a control group, photodamage, uneven skin ttone, roughness and fine and coarse wrinkles improved significantly.Assessing changes in facial skin quality using noninvasive in vivo clinical skin imaging techniques after use of a topic…
- In 20 adults with photoaged face and neck skin, a 0.2% retinol cream with tripeptides and glaucine used for 3 months produced clinical and tissue improvements in all 20 participants.Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the…
- A topical retinol cream gave better skin barrier and wrinkling scores than a vitamin E cream and limited shallow wrinkles caused by UV exposure.Topical retinol and the stratum corneum response to an environmental threat.
- In a retrospective study of 129 patients, a hybrid filler containing calcium hydroxylapatite improved facial appearance, firmness, and elasticity at 9 months, with only minor side effects.HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.
- In 40 patients, injected calcium hydroxylapatite, alone or after a topical exosome treatment, improved skin tone, quality, and texture over 30 days, and the combination worked faster.Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation.
- In 32 adults aged 35 to 59, diluted calcium hydroxylapatite injections gave visible improvement in 85% of patients at 120 days, with 75% still reporting benefit at 360 days, and dermal thickness rose 51% on ultrasound in a subset.Clinical Evaluation of an Innovative CaHA Bio-Stimulator in Facial Rejuvenation: 1 Year Follow-Up.
- In a pilot study of 3 people, calcium hydroxylapatite particles persisted for 6 months with new collagen formation, and patients still showed clinical improvement at that time.Clinical, histologic and electron microscopic findings after injection of a calcium hydroxylapatite filler.
- In a case series, priming the skin with a micronutrient diluent before calcium hydroxylapatite improved wrinkles, laxity, and skin thickness in all patients after a single treatment.Optimizing Skin Regenerative Response to Calcium Hydroxylapatite Microspheres Via Poly-Micronutrient Priming.
- In 33 Chinese women aged 20 to 45, a supramolecular retinol eye cream used for 6 weeks reduced dark circles, fine wrinkles and sagging, and firmness (skin elasticity) rose by 13%, with good tolerance.Improvement of urban eye skin in Chinese female by supramolecular retinol plus acmella oleracea extract-containing produ…
- In 31 people with melasma and facial photodamage, a 4% hydroquinone plus 1% retinol regimen over 24 weeks improved melasma and photodamage, with fine wrinkles, crepiness, and laxity improving by week 8 and most attributes improving in over three quarters of participants.Clinical Evaluation of a 4% Hydroquinone + 1% Retinol Treatment Regimen for Improving Melasma and Photodamage in Fitzpat…
- This review describes an injectable calcium-based filler, Radiesse, approved in 2006 to correct moderate to severe facial wrinkles, with the correction lasting about one year; it reports no numbers of people, trial results, or comparison with a control group.Injectable calcium hydroxylapatite microspheres (Radiesse).
Review Totals and Summary
Members OnlyWhat buyers say
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
Vitamin D is the main ingredient and the panel backs it clearly: all ten spoke about it, and most recommend it or take it themselves. Three of them take 5000 units of the D3 form in the morning for general health, and one says to take it with dietary fat for better absorption, while others get it from salmon or sardines. They give reasons such as bone and muscle support, brain health, immunity and fixing low levels, and a few aim for blood levels in the range of 40 to 80, though one notes there is little point supplementing unless you are low. Vitamin C is also a main ingredient, and several recommend it, often paired with collagen before a workout, for skin, joints and immune support, with one noting a doctor once warned him off it. Iron is a smaller ingredient in this product, and one panelist said he stopped because no form of it raised his low levels for years.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin D · neutral
- Lists Vitamin D as an ingredient found in sardines.
- States that one can of sardines contains 382 mg of calcium.
- Mentions that the body relies on healthy fats to absorb essential vitamins like A, D, E, and K, which help support skin health, moisture, and normal cell function.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Warns against iron supplements, suggesting instead to get iron from red meat or liver.
- Dr. Berg states that when nutrients like iron are too low, fatigue and weakness can follow.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
Dr. Rhonda Patrick · Vitamin D · neutral
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
Thomas DeLauer · Vitamin C · recommends
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Recommends giving any iron intervention a couple of months before deciding if it works, and suggests increasing heme iron through red meat or liver intake.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
Dr. Mark Hyman · Vitamin D · uses
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- States that iron helps red blood cells carry oxygen, and a deficiency can make one feel like they are running on low power mode.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
Dave Asprey · Vitamin C · neutral
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Recommends taking vitamin C for better skin health.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Recommends real vitamin A for people on the spectrum, noting that many cannot convert plant vitamin A and need the good stuff he includes in his Vitam DAKNE product.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Mentions that iron is a mineral necessary for making collagen.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists dairy and sardines as sources of Calcium.
- Lists liver and carrots as sources of Vitamin A.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Notes that Vitamin C is one of several supplements with human evidence.
- States that excess iron promotes oxidative stress and inflammation, which increases heart disease risk.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
Ben Greenfield · Vitamin C · recommends
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
- Mentions vitamin C as part of a bare-minimum protocol.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
Bryan Johnson · Vitamin D · uses
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
- Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
Andrew Huberman · Vitamin D · neutral
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- States that Iron is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
- Takes a multivitamin every day for longevity.
- Takes a multivitamin every day for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
RAL Summary
Members OnlyTier 4 for Younger-Looking Skin for Women
Emerging because the strong vitamin A, vitamin C and calcium results come from creams and injections rather than a pill, and oral vitamin A and C did not help skin. There are also no reviews yet.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 7 of the 71 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skin
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: Studies of stronger retinol creams reported dryness, scaling and stinging, but these were skin-applied products, not this pill. No reviews have been read.
Supplement Facts
Vitamin A 1200 mcg RAE · Vitamin C 12 mg · Vitamin D 1.2 mcg
| Vitamin A | 1,200 mcg RAE | |
| Vitamin C | 12 mg | |
| Vitamin D | 1.2 mcg | |
| Calcium | 40 mg | |
| Iron | 0.7 mg | |
| Traditional Wellness Support Blend | 11 mg | † |
| Green Leaf Blend | 10 mg | † |
| Cellular and Skin Protection Blend | 9 mg | † |
Other ingredients: Vegetarian Capsule, Cellulose, Plant, Magnesium Stearate, Silica.
Directions: Suggested Use: Take two capsules daily, with or without food.
Barcode (UPC) 854389007187 · Label source: NIH label database · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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