Liquid I.V. Hydration Multiplier Electrolyte Drink Mix, Seaberry Review
Liquid I.V. Hydration Multiplier in Seaberry is an electrolyte drink mix sold as a powder in single serve sticks. One serving is 1 stick (16 g), and each container holds 16 servings. The label prints these amounts per serving: sodium 500 mg, potassium 370 mg, vitamin C 62 mg, niacin 19.3 mg, vitamin B6 1.93 mg, vitamin B12 5.79 mcg and pantothenic acid 9.6 mg. It also lists 11 g of total carbohydrate, all of it sugars and all of those added sugars. A serving has 45 calories, with 0 g of fat and 0 g of protein. The sodium and potassium are the electrolytes on the panel, and the B vitamins and vitamin C come alongside them. No directions for use are printed in the label text provided here, so check the packaging in your hand for mixing instructions. If you are comparing tubs and boxes on the shelf, the count of 16 sticks and the 16 g stick size are the figures to match against other mixes, along with the sodium and sugar amounts per stick.
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Study, Trial or Testing Result Summary
Members Only100 human studies · 35 improved
13 of these 100 human studies gave the ingredient by drip or injection, not by mouth.
No study tested this drink mix itself, and the evidence on its ingredients for energy is mixed. Potassium was studied only in diets and drinks, not as a supplement on its own. A low-salt, high-potassium diet improved vigour and mood but not fatigue [1], while a larger trial linked such a diet to more fatigue [2]. Runners recovering with a potassium-containing sports drink later ran about 16 percent longer [3]. Vitamin C here is 62 mg, below the 250 mg that improved well-being and fatigue in young adults with low vitamin C [4]. Larger trials in people who were not low found no benefit [5]. For vitamin B3, a review of related compounds found no gain for tiredness [6], and a related form at high doses did not ease long COVID fatigue [7]. Vitamin B6 is at a trace amount, far below the 50 mg studied [8]. Vitamin B12 did not boost energy in people without a deficiency [9]. Pantothenic acid, at doses far above this product, did not improve exercise performance in two small trials [10][11]. Animal and cell studies are never counted.
See all 100 studies →Hide the studies
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- Across 27 studies of 1,599 adults, NAD+ precursors did not improve perceived fatigue or sleep, but nicotinamide mononucleotide improved endurance and NADH improved cognitive performance.Domain-specific effects of NAD+ precursors on fatigue and functional performance: a systematic review and network meta-a…
- In two placebo-controlled trials of 404 adults with Charcot-Marie-Tooth disease type 1A, ascorbic acid at two doses over 12 to 24 months had little meaningful effect on fatigue.Interventions for fatigue in peripheral neuropathy.
- Across nine studies of 720 people, three of four controlled trials found intravenous vitamin C lowered fatigue scores more than control, and four of five uncontrolled studies saw fatigue fall.Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review o…
- In 10 trials of 489 people, NADH was well tolerated and linked to better quality of life, less anxiety and lower heart rate after stress, but fatigue results were not clearly shown.Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of 37 studies in cancer patients found intravenous vitamin C may ease fatigue and other symptoms, but the evidence is preliminary and mostly uncontrolled.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of supplements for football players said vitamin C may improve performance by lowering oxidative stress, but gave no numbers and called for more research.The efficacy of dietary supplements on health status and performance of football players: a systematic review.
- A review of 14 reviews found oral niacin and nicotinamide can cause side effects including fatigue, stomach upset, flushing and liver problems, more often at higher doses and with niacin than nicotinamide.The adverse effects of oral niacin/nicotinamide - an overview of reviews.
- In 8112 healthy French adults, a daily antioxidant capsule containing 120 mg vitamin C for about 6 years did not change quality of life scores, including vitality, compared with placebo.Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, pla…
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 697 adults with mild high blood pressure, a low-sodium, high-potassium diet with placebo for 6 months was linked to more fatigue (34%) than the usual diet (18%) or a weight loss diet (15%).Effect of antihypertensives on sexual function and quality of life: the TAIM Study.
- In 275 adults with early COVID-19 given a 10-day combination that included vitamin C, less fatigue at day 14 was seen only when famotidine was added, not with the vitamin C combination alone.Read the study on PubMed (41693032) →
- In 271 adults with Charcot-Marie-Tooth disease type 1A, 1.5 g of ascorbic acid daily for 2 years did not differ from placebo on neuropathy or on secondary outcomes including fatigue.Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement for 33 days improved vigour, stress and mental health ratings and made them feel less mentally tired than placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 202 hemodialysis patients, a multinutrient supplement containing vitamin C for 12 weeks did not reduce fatigue compared with placebo, though some heart rate variability measures improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 14 days improved vitality and motivation, but blood vitamin C did not explain these benefits.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit gave somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In 160 heart bypass surgery patients, vitamin C plus omega-3 fatty acids given from the day before surgery through the first 5 days after reduced post-operative fatigue more than placebo.The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass gra…
- In 160 heart disease patients over about 38 months, niacin plus a med caused fatigue, nausea or muscle aches in 9% versus 5% on placebo, not a significant difference.Read the study on PubMed (14759379) →
- In 141 healthy office workers, a single 10 gram intravenous vitamin C dose lowered fatigue scores for up to one day compared with saline placebo, especially in those with low starting vitamin C, and also lowered oxidative stress.Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
- In a 3-month double-blind trial of 99 people with severe kidney failure taking 250 mg vitamin C three times weekly, symptoms including fatigue were similar to placebo, and nausea trended worse with vitamin C.Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
- In a crossover trial of 94 adults, 4 weeks on a low-sodium, high-potassium diet improved vigour, depression, tension and overall mood more than a moderate-sodium DASH-type diet, but fatigue was not shown to improve.Dietary electrolytes are related to mood.
- In 86 people with mental fatigue, a single dose of homeopathic potassium phosphate taken before an attention test did not work better than placebo, though the test's ceiling effect limits the result.Homeopathy for mental fatigue: lessons from a randomized, triple blind, placebo-controlled cross-over clinical trial.
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 58 healthy adults with mild prolonged tiredness, a supplement combining pomegranate extract with B vitamins and vitamin C reduced fatigue scores over 8 weeks compared with placebo, though vitamin C was not tested alone and biochemical markers did not change.Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monoce…
- In 58 people with long-COVID, 2000 mg of nicotinamide riboside daily raised blood NAD+ about 3-fold but did not significantly improve fatigue, cognition, or sleep versus placebo.Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled …
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 50 people recovering from COVID-19, one month of 1-methylnicotinamide improved 6-minute walk distance in 92% versus 60% without it, and severe fatigue was 20% versus 56%.Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19.
- In healthy young adults with low vitamin C levels, 500 mg twice a day for 4 weeks improved attention and work absorption compared with placebo, with a trend toward less fatigue.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In a 28-day placebo-controlled trial of 46 adults with long COVID, twice-daily liposomal vitamin C (500 mg) with l-arginine reduced persistent fatigue (2 of 23 still fatigued vs 21 of 23 on placebo) and improved walking distance and handgrip strength.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 43 adults with sleep complaints, a blend containing a small amount of vitamin B3 taken with the evening meal for 14 days shortened sleep onset time and improved next-morning mood and vigor, but had no effect on cognitive performance.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 healthy adults aged 40-76, a glycine, glutamine and niacin mixture taken for 3 weeks raised growth hormone by about 70% compared with placebo, but did not change IGF-I, mood or memory.Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 40 young adults with low vitamin C, 1000 mg daily for 4 weeks improved mental vitality and reduced inflammation compared with placebo, with gut bacteria changes linked to the gains.Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitam…
- In 36 volunteers, 1 g of vitamin C daily for 30 days improved maximal oxygen uptake and lowered oxidative stress only in those with the lowest vitamin C levels, and it did not reduce fatigue index.Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
- In 32 Gulf War veterans with illness, a 4-6 week program of exercise, sauna and nicotinic acid plus other supplements improved physical quality of life by 6.9 points versus waitlist, and 11 of 16 quality of life, pain and fatigue measures improved.A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 28 men with marginal vitamin C status, 1000 mg daily for 8 weeks produced a physical activity rise that was not statistically significant compared with placebo, though cold episodes were fewer.Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vit…
- In 26 overweight middle-aged women doing aerobic training for 3 months, drinking 500 mL of orange juice daily was linked with lower blood lactate, suggesting less muscle fatigue than training alone.Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training.
- Eating two SunGold kiwifruit daily for 4 weeks improved mood disturbance, wellbeing and vitality compared with usual diet in 26 adults with mild to moderate mood disturbance.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 25 healthy young adults, a single dose of a pre-workout drink containing 500 mg vitamin C along with other ingredients raised self-rated energy and vigour compared with placebo, though adding synephrine gave no extra benefit.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 breast cancer survivors, 500 mg vitamin C plus vitamin E daily for 10 weeks alongside strength training did not reduce fatigue more than placebo.Effect of strength training and antioxidant supplementation on perceived and performance fatigability in breast cancer s…
- In a double-blind crossover trial of 25 resistance-trained adults, 7 days of a pre-workout drink containing 65 mg niacin (plus caffeine and other ingredients) improved some lower-body strength and endurance measures compared with placebo, but not cycling time-trial performance, with no differences in side effects.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 25 untrained men, a single 1000 mg dose of niacin before cycling raised the respiratory exchange ratio and shortened time to exhaustion compared with caffeine, suggesting impaired exercise performance.Niacin supplementation impairs exercise performance.
- In 21 untrained men, a caffeine supplement containing 40 mg of niacin taken once did not improve bench press strength, leg extension strength, or time to exhaustion on a bike compared with placebo.Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion durin…
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during exercise compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 18 healthy volunteers, 1000 mg a day of ascorbic acid for 8 days did not reduce physical fatigue during a long cycling task, while a different product did.Effects of Applephenon and ascorbic acid on physical fatigue.
- In 17 people doing hard cycling at high altitude, a 3-week broad antioxidant capsule that included vitamin C did not improve performance; a different supplement combination did better than both this capsule and placebo.Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In 14 healthy volunteers, 3000 mg a day of ascorbic acid for 8 days did not change physical fatigue during a long cycling task compared with placebo.Daily oral administration of crocetin attenuates physical fatigue in human subjects.
- In 12 middle-aged triathletes during a 90-minute cycling session, taking vitamin C with glutathione improved energy-related metabolic and heart measures and lowered an oxidative stress marker compared with placebo, though vitamin C was not tested alone and this was a single acute session.Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Perf…
- In eight men, a glucose drink lowered blood potassium during and after intense cycling, but it did not delay fatigue compared with placebo.A single oral glucose load decreases arterial plasma [K+ ] during exercise and recovery.
- In 8 healthy young men, one week of 1.5 grams each of pantothenic acid and cysteine daily did not change muscle coenzyme A, fuel use during exercise, or work output compared with placebo.Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exerci…
- In 7 well-trained runners, drinking a prescribed volume of a potassium-containing carbohydrate-electrolyte drink during 4 hours of recovery from a long run let them keep running about 16% longer later than drinking as much as they wanted.Influence of fluid intake pattern on short-term recovery from prolonged, submaximal running and subsequent exercise capa…
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In a placebo-controlled crossover pilot in healthy middle-aged adults, 7 days of RiaGev (1520 mg twice daily) raised blood NAD+ metabolites and reduced fatigue and improved concentration and motivation compared with baseline, with no clinically relevant side effects.A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-…
- In 155 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks only marginally improved mood until day 12, with effects weaker than kiwifruit, though mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 70 diabetic fatty liver patients, 1000 mg of nicotinamide daily for 12 weeks improved quality of life including the activity and fatigue scores versus no supplement, in an open-label trial.Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial.
- In 61 hemodialysis patients, 100 mg of intravenous vitamin C after each session for 6 months did not improve energy-related quality of life or red blood cell production compared with no vitamin C.Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients.
- In 14 trained male cyclists, 6 grams of pantothenic acid daily for 16 weeks did not change muscle coenzyme A levels or cycling performance compared with the control group.Chronic pantothenic acid supplementation does not affect muscle coenzyme A content or cycling performance.
- In 8 people with COPD, a single 2 g IV vitamin C dose compared with saline reduced quadriceps neuromuscular fatigue and lowered inflammatory C-reactive protein during exercise, but did not improve breathlessness or exercise tolerance.Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise…
- In 7 male triathletes, 6 weeks of a daily antioxidant capsule containing 600 mg ascorbic acid did not change maximal oxygen uptake or muscle fatigue compared with placebo.No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabo…
- In 214 outpatients with COVID-19, 8000 mg ascorbic acid for 10 days did not shorten symptoms, including fatigue, compared with usual care.Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulator…
- In an open-label trial of 40 head and neck cancer survivors, 100 mg vitamin C tablets daily for 8 weeks gave less fatigue relief than Tualang honey.Effects of Tualang Honey on Cancer Related Fatigue: A Multicenter Open-label Trial of H&N Cancer Patients.
- In 39 advanced cancer patients with cachexia, a 4-month combined treatment including 500 mg daily vitamin C improved fatigue scores and lowered inflammatory markers, but the study had no placebo group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In a small uncontrolled pilot of 23 iron-deficient women, a daily food-derived supplement that also contained vitamin C was taken for 8 weeks, and self-reported energy improved, though vitamin C alone was not tested and there was no placebo group.A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Def…
- In a survey of complementary medicine practitioners giving IV vitamin C (average 28 g every 4 days), 59 of 9,328 patients with data had lethargy or fatigue as a side effect, and most side effects were minor.Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In 1,643 Spanish adults aged 65 and over followed for about 3.5 years, low dietary vitamin C intake was linked to a higher risk of frailty, which includes exhaustion, but this link was not statistically significant on its own.Low vitamin intake is associated with risk of frailty in older adults.
- In a 90-day follow-up of 923 Indonesian COVID-19 survivors, vitamin C combined with other micronutrients and favipiravir did not significantly change post-COVID symptoms, including fatigue, which was the most common symptom.Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: A longitudinal study.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In a survey of 576 people in Syria who had COVID-19, 76.4% reported using vitamin C, but the survey did not measure whether vitamin C improved energy or fatigue, and fatigue was the most reported symptom.COVID-19 infected patients' experiences in Syria, and the role of the pharmacists during their infection.
- In 411 dentists and their wives, people who took little vitamin C reported about double the number of fatigue symptoms compared with those who took more.Daily vitamin C consumption and fatigability.
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- In a retrospective German cohort of 125 breast cancer patients, adding intravenous vitamin C of 7.5 g for at least 4 weeks was associated with fewer treatment side effects, including fatigue, than no added vitamin C.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- In a retrospective chart review of 86 cancer patients given high-dose IV vitamin C (50 to 150 g per infusion), patients overall reported improved fatigue, pain, and mood, with temporary nausea and injection-site discomfort as the most common side effects.Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.
- In 67 adults with shingles, about 2 weeks of intravenous vitamin C alongside standard treatment was followed by reduced pain and less general fatigue, but the study had no placebo group.Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
- In hypertensive patients, a nicotinamide mononucleotide supplement lowered blood pressure and improved vascular function, but energy was not measured.NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension.
- In this mostly lab and animal study, nicotinamide with pyridoxine helped muscle stem cells regenerate muscle and improved strength in animals, but energy was not measured.Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
- In mice, pantothenate deficiency lowered tissue levels of coenzyme A and glycogen stores and shortened running time to exhaustion compared with supplemented mice.The effect of pantothenate deficiency in mice on their metabolic response to fast and exercise.
Review Totals and Summary
Members Only3,328 reviews · 93% positive
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Biohacker Summary
Members Only10 of 10 recommend it
The panel talks about several main ingredients here, and vitamin C gets the most attention, with most of the ten recommending or using it. They take it mainly for collagen, skin and joints, and four of them pair it with collagen or mention taking it alongside it, while one cites doses of 500 mg to 1 g and another takes 250 mg. Foods such as citrus, kiwi, bell peppers and sauerkraut come up as sources, one prefers whole food vitamin C, and one cautions that high doses might blunt the benefits of exercise. One person stopped using a vitamin C serum because of its smell, and another noted that applying it to the skin reaches levels that eating it cannot. Potassium is mostly recommended or used, often in sugar free electrolyte drinks taken in the morning or around workouts, and one panelist prefers getting it from foods like bananas and potatoes over supplements, while another warns only about an additive in bread. Vitamin B12 gets only neutral mentions from a few panelists, who link low levels to tiredness, weakness and hair loss, and niacin is a smaller ingredient in this product that only a couple of them touch on.
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Dr. Eric Berg · Vitamin B12 · neutral
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Recommends potassium as an important electrolyte, noting that most people get less than half of the 4700 mg RDA.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- States that vitamin B6 is needed to absorb magnesium.
- States that people need more potassium than any other mineral, yet most people aren’t getting enough.
- Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Explains that the normal requirements for potassium are 4,700 mg every single day, and that very few people get half of that amount. They describe potassium's role in the sodium potassium pump, which is essential for cellular electricity, muscle contraction, and heart function. Deficiency can lead to tiredness, muscle cramps, heart palpitations, or rising blood pressure.
- Recommends increasing potassium to restore balance and support healthy blood pressure.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
Thomas DeLauer · Vitamin C · recommends
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
- Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Element's ready-to-drink sparkling electrolyte drinks as a low or zero-calorie soda replacement that provides 1,000 milligrams of sodium, 200 milligrams of potassium, and 60 milligrams of magnesium.
- Uses Element Electrolytes for about eight years, noting they contain 1000 mg sodium, 200 mg potassium, and 60 mg magnesium, and help curb appetite without adding many calories.
Dave Asprey · Potassium · recommends
- Explains that potassium helps open a gate, allowing creatine to slip through and cross the blood-brain barrier more effectively.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
- Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
- States that Ensure is like SlimFast but worse, and that its ingredients, including synthetic vitamins, guar gum, maltodextrin, high fructose corn syrup, and seed oils, are disgusting and should not be given to sick or well people.
Ben Greenfield · Vitamin C · recommends
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
- Mentions niacin as a natural approach that might be good for plaque regression.
- Warns against ascorbic acid, stating that it does not cure scurvy and that the world has been led astray by the deception around it versus the whole food vitamin C complex.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists potatoes and fruit as sources of Potassium.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that bananas have potassium but there are at least 8 other foods with more potassium than bananas.
- States that potassium is the most abundant intracellular cation that helps to maintain intracellular fluid volume and that without it, one greatly increases the risk of hypertension, cardiovascular disease, diabetes, and stroke.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
Dr. Mark Hyman · Potassium · warns
- Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- States that potassium plays a critical role in nerve signaling and muscle contraction, especially in the heart, and low levels can lead to dangerous irregular heart rhythms.
- Notes that meds flush out potassium.
- Recommends vitamin C for immune system support and modulation.
Peter Attia · Potassium · recommends
- States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
- Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
- Recalls that a flush from niacin typically occurred with doses of a few grams.
- Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
- He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
Dr. Rhonda Patrick · Vitamin C · neutral
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Rhonda's current supplement routine includes Vitamin C.
- States that maintaining a high potassium intake is important for hypertension.
- States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
Andrew Huberman · Potassium · uses
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes a multivitamin every day for longevity.
- Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Mentions potassium as an electrolyte.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, drinking it first thing in the morning and during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure he is hydrated and has sufficient electrolytes. He drinks it first thing in the morning and during physical exercise, especially on hot days.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium but no sugar, to ensure adequate hydration and electrolytes, especially when waking up and during exercise.
- Uses LMNT, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes for brain and body function, especially when starting his day fast or during physical exercise.
- Uses Element, which contains potassium, for proper hydration and electrolyte balance.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Ensures adequate intake of sodium, magnesium, and potassium, which are vital electrolytes for the functioning of all body cells, especially neurons, by drinking Element.
Bryan Johnson · Vitamin B12 · uses
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 250 milligrams of Vitamin C.
RAL Summary
Members OnlyTier 4 for Energy
The ineffective grade leans on studies of blends, diets and related but different compounds, such as nicotinamide riboside and other vitamin B3 forms rather than plain niacin, while vitamin C and potassium results are mixed and 93 percent of 3328 reviews are positive, so the evidence is mixed rather than showing it does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 49 of the 100 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Muscular system, Cardiovascular system, Metabolic system
Combine with: For Energy, the B vitamins in this mix are often paired with magnesium, which helps enzymes turn food into usable cellular fuel and works in the same pathways as the B vitamins. Iron is often paired with them because it carries oxygen and the body uses it in energy making steps. Coenzyme Q10 is often paired with them because it works in the cell's energy chain. Creatine is often paired with them for muscle energy stores.
Possible side effects: High doses of niacin can cause flushing, stomach upset, fatigue and liver problems, though this product's dose is far lower; each serving also has 11 grams of added sugar.
Supplement Facts
Includes Added Sugars 11 g · Potassium 370 mg · Vitamin C 62 mg
| Calories | 45 | |
| Total Fat | 0 g | |
| Sodium | 500 mg | |
| Total Carbohydrate | 11 g | |
| Total Sugars | 11 g | |
| Includes Added Sugars | 11 g | |
| Protein | 0 g | |
| Potassium | 370 mg | |
| Vitamin C | 62 mg | |
| Niacin | 19.3 mg | |
| Vitamin B6 | 1.93 mg | |
| Vitamin B12 | 5.79 mcg | |
| Pantothenic Acid | 9.6 mg |
Barcode (UPC) 850039286476 · Label source: Liquid-iv · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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